LYPD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the LY6 protein family (see SLURP1; MIM 606119), such as LYPD6, have at least one 80-amino acid LU domain that contains 10 conserved cysteines with a defined disulfide-bonding pattern (Zhang et al., 2010 [PubMed 19653121]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.27365492
2synaptic vesicle maturation (GO:0016188)4.97398952
3vocalization behavior (GO:0071625)4.91631341
4locomotory exploration behavior (GO:0035641)4.85583364
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.76150503
6glutamate secretion (GO:0014047)4.66896659
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.66876412
8neuron cell-cell adhesion (GO:0007158)4.65036942
9layer formation in cerebral cortex (GO:0021819)4.58803142
10regulation of glutamate receptor signaling pathway (GO:1900449)4.56136960
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.53889093
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.49929740
13regulation of synaptic vesicle exocytosis (GO:2000300)4.36143254
14protein localization to synapse (GO:0035418)4.30452218
15neurotransmitter secretion (GO:0007269)4.11783369
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.10170849
17synaptic vesicle docking involved in exocytosis (GO:0016081)3.98714595
18neuronal action potential propagation (GO:0019227)3.98008282
19gamma-aminobutyric acid transport (GO:0015812)3.95671127
20glutamate receptor signaling pathway (GO:0007215)3.87587306
21exploration behavior (GO:0035640)3.87529797
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.85805680
23synaptic transmission, glutamatergic (GO:0035249)3.84283492
24regulation of synaptic vesicle transport (GO:1902803)3.77987281
25transmission of nerve impulse (GO:0019226)3.77529565
26proline transport (GO:0015824)3.76591465
27neurotransmitter-gated ion channel clustering (GO:0072578)3.73791072
28regulation of synapse structural plasticity (GO:0051823)3.69103866
29postsynaptic membrane organization (GO:0001941)3.65944171
30neuron-neuron synaptic transmission (GO:0007270)3.63581787
31neuron recognition (GO:0008038)3.60431584
32dendritic spine morphogenesis (GO:0060997)3.58598187
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.54803597
34paraxial mesoderm development (GO:0048339)3.53344631
35regulation of neuronal synaptic plasticity (GO:0048168)3.52512524
36neurotransmitter transport (GO:0006836)3.47850335
37G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.46274033
38protein localization to kinetochore (GO:0034501)3.44790988
39gamma-aminobutyric acid signaling pathway (GO:0007214)3.39753822
40presynaptic membrane organization (GO:0097090)3.37750559
41chromatin remodeling at centromere (GO:0031055)3.36076422
42presynaptic membrane assembly (GO:0097105)3.34889346
43regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.34765414
44CENP-A containing nucleosome assembly (GO:0034080)3.33524429
45axonal fasciculation (GO:0007413)3.32904457
46cellular potassium ion homeostasis (GO:0030007)3.32268003
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31680261
48long-term memory (GO:0007616)3.30045164
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.29201076
50regulation of neurotransmitter levels (GO:0001505)3.28814624
51axon ensheathment in central nervous system (GO:0032291)3.27155470
52central nervous system myelination (GO:0022010)3.27155470
53L-amino acid import (GO:0043092)3.27075994
54positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.26959056
55amino acid import (GO:0043090)3.25127649
56ventricular cardiac muscle cell development (GO:0055015)3.24759514
57long-term synaptic potentiation (GO:0060291)3.23594162
58cerebellar granule cell differentiation (GO:0021707)3.23294152
59dendrite morphogenesis (GO:0048813)3.20518794
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.20311381
61cell migration in hindbrain (GO:0021535)3.19284449
62positive regulation of membrane potential (GO:0045838)3.17722692
63regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.15756541
64negative regulation of synaptic transmission, GABAergic (GO:0032229)3.15473499
65response to auditory stimulus (GO:0010996)3.14907032
66mitotic metaphase plate congression (GO:0007080)3.11700685
67regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.09355500
68cerebral cortex radially oriented cell migration (GO:0021799)3.09085308
69regulation of dendritic spine morphogenesis (GO:0061001)3.06511116
70neuronal ion channel clustering (GO:0045161)3.05967677
71regulation of synaptic transmission, glutamatergic (GO:0051966)3.05050301
72regulation of excitatory postsynaptic membrane potential (GO:0060079)3.04650949
73regulation of centriole replication (GO:0046599)3.04226384
74auditory behavior (GO:0031223)3.04075564
75establishment of integrated proviral latency (GO:0075713)3.03364853
76regulation of neurotransmitter uptake (GO:0051580)3.03111096
77neurotransmitter uptake (GO:0001504)3.02886863
78positive regulation of synaptic transmission, GABAergic (GO:0032230)3.01638007
79regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00734070
80protein localization to chromosome, centromeric region (GO:0071459)3.00179770
81sodium ion export (GO:0071436)2.97974925
82neuromuscular process controlling balance (GO:0050885)2.97170481
83synaptic vesicle endocytosis (GO:0048488)2.96759842
84membrane hyperpolarization (GO:0060081)2.96229495
85regulation of neurotransmitter transport (GO:0051588)2.95859854
86regulation of neurotransmitter secretion (GO:0046928)2.95077364
87activation of protein kinase A activity (GO:0034199)2.94179152
88regulation of postsynaptic membrane potential (GO:0060078)2.94053376
89synapse assembly (GO:0007416)2.93501052
90regulation of synaptic plasticity (GO:0048167)2.93291398
91negative regulation of neurotransmitter transport (GO:0051589)2.90171663
92cerebellar Purkinje cell differentiation (GO:0021702)2.88827923
93regulation of synaptic transmission, GABAergic (GO:0032228)2.87682457
94cell communication by electrical coupling (GO:0010644)2.82960962
95regulation of vesicle fusion (GO:0031338)2.82208232
96learning (GO:0007612)2.80687632
97notochord development (GO:0030903)2.80429320
98cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.79920039
99synaptic transmission (GO:0007268)2.76995841
100outer ear morphogenesis (GO:0042473)2.76000940
101metaphase plate congression (GO:0051310)2.75862462
102synapse organization (GO:0050808)2.74629414
103neurotransmitter catabolic process (GO:0042135)2.74229024
104positive regulation of synaptic transmission (GO:0050806)2.71536830
105regulation of synaptic transmission (GO:0050804)2.70202308
106histone exchange (GO:0043486)2.70053332
107acidic amino acid transport (GO:0015800)2.69965620
108adult walking behavior (GO:0007628)2.69485331
109startle response (GO:0001964)2.69431139
110positive regulation of potassium ion transmembrane transport (GO:1901381)2.69418809
111neuromuscular process (GO:0050905)2.69395504
112positive regulation of synapse assembly (GO:0051965)2.69381034
113mitotic chromosome condensation (GO:0007076)2.68480336
114regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.68380427
115regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.68380427
116kinetochore organization (GO:0051383)2.63879684
117DNA replication-independent nucleosome assembly (GO:0006336)2.61810883
118DNA replication-independent nucleosome organization (GO:0034724)2.61810883
119regulation of cardioblast differentiation (GO:0051890)2.60532700
120negative regulation of keratinocyte proliferation (GO:0010839)2.56212777
121negative regulation of chondrocyte differentiation (GO:0032331)2.49105027
122mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.48960014
123DNA replication checkpoint (GO:0000076)2.48553684
124cullin deneddylation (GO:0010388)2.47676073
125bundle of His cell to Purkinje myocyte communication (GO:0086069)2.47492648
126hippo signaling (GO:0035329)2.43013295
127axon extension involved in axon guidance (GO:0048846)2.41977839
128neuron projection extension involved in neuron projection guidance (GO:1902284)2.41977839
129gastrulation with mouth forming second (GO:0001702)2.41392881
130ectodermal placode formation (GO:0060788)2.39292170
131DNA double-strand break processing (GO:0000729)2.39231420
132DNA unwinding involved in DNA replication (GO:0006268)2.38977038
133polarized epithelial cell differentiation (GO:0030859)2.38645939
134DNA strand elongation involved in DNA replication (GO:0006271)2.38278634
135DNA strand elongation (GO:0022616)2.36485640
136lateral sprouting from an epithelium (GO:0060601)2.33123080
137dorsal/ventral axis specification (GO:0009950)2.32388024
138anterior/posterior axis specification, embryo (GO:0008595)2.31260838
139telomere maintenance via semi-conservative replication (GO:0032201)2.29648889
140negative regulation of axon extension involved in axon guidance (GO:0048843)2.27743896
141mitotic sister chromatid segregation (GO:0000070)2.27158790
142double-strand break repair via nonhomologous end joining (GO:0006303)2.24846417
143non-recombinational repair (GO:0000726)2.24846417
144resolution of meiotic recombination intermediates (GO:0000712)2.24029139
145regulation of transforming growth factor beta2 production (GO:0032909)2.23585149
146establishment of viral latency (GO:0019043)2.23153428
147kinetochore assembly (GO:0051382)2.22084231
148regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.20448751
149muscle cell fate commitment (GO:0042693)2.19575203
150sister chromatid segregation (GO:0000819)2.18916662
151negative regulation of stem cell proliferation (GO:2000647)2.17218761
152protein deneddylation (GO:0000338)2.17022705
153spindle assembly involved in mitosis (GO:0090307)2.15400109
154generation of neurons (GO:0048699)2.13876447
155regulation of centrosome cycle (GO:0046605)2.13363938
156L-serine metabolic process (GO:0006563)2.11658169
157ATP-dependent chromatin remodeling (GO:0043044)2.11292659
158embryonic foregut morphogenesis (GO:0048617)2.09238936
159bone trabecula formation (GO:0060346)2.08195676
160mitotic recombination (GO:0006312)2.07496589
161nuclear pore organization (GO:0006999)2.07208722
162regulation of helicase activity (GO:0051095)2.06072152
163establishment or maintenance of bipolar cell polarity (GO:0061245)2.05957747
164establishment or maintenance of apical/basal cell polarity (GO:0035088)2.05957747
165regulation of chromosome segregation (GO:0051983)2.05899436
166establishment of tissue polarity (GO:0007164)2.05789209
167establishment of planar polarity (GO:0001736)2.05789209
168nuclear pore complex assembly (GO:0051292)2.05447869
169establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.05027412
170establishment of chromosome localization (GO:0051303)2.04827500
171asymmetric protein localization (GO:0008105)2.04129197
172midgut development (GO:0007494)2.03695047
173negative regulation of axon guidance (GO:1902668)2.02679347
174regulation of heart morphogenesis (GO:2000826)2.02204864
175mitotic spindle organization (GO:0007052)2.02159739
176planar cell polarity pathway involved in neural tube closure (GO:0090179)2.02110844
177negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.01579260
178negative chemotaxis (GO:0050919)2.01491312
179chromosome condensation (GO:0030261)1.99886067
180Wnt signaling pathway, planar cell polarity pathway (GO:0060071)1.99290127
181outflow tract septum morphogenesis (GO:0003148)1.99208840
182cell surface receptor signaling pathway involved in heart development (GO:0061311)1.97384707
183regulation of cell proliferation involved in heart morphogenesis (GO:2000136)1.97186406
184spindle checkpoint (GO:0031577)1.96881545
185regulation of spindle organization (GO:0090224)1.96012095
186nucleotide-excision repair, DNA gap filling (GO:0006297)1.95927654
187regulation of centrosome duplication (GO:0010824)1.95217051
188positive regulation of dendritic spine morphogenesis (GO:0061003)1.93994425
189regulation of establishment of planar polarity (GO:0090175)1.93237318
190organ induction (GO:0001759)1.92992280
191telomere maintenance via recombination (GO:0000722)1.92700864
192protein localization to chromosome (GO:0034502)1.92552207
193microtubule cytoskeleton organization involved in mitosis (GO:1902850)1.92481515
194female gonad development (GO:0008585)1.92122858
195regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.91965463
196apical protein localization (GO:0045176)1.91174782
197G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.90162532
198regulation of double-strand break repair via homologous recombination (GO:0010569)1.88894476
199regulation of keratinocyte proliferation (GO:0010837)1.88347640

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.23338429
2E2F7_22180533_ChIP-Seq_HELA_Human4.27397304
3GBX2_23144817_ChIP-Seq_PC3_Human3.71387701
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18074191
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.15568648
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09487046
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08691315
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.89607283
9AR_21909140_ChIP-Seq_LNCAP_Human2.78789953
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76645879
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76645879
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.63487186
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62950346
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62730260
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62725866
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.61216153
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.59401026
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44735471
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.42129624
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36790313
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.33188139
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.32674495
23REST_21632747_ChIP-Seq_MESCs_Mouse2.30280458
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.28093682
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.27106981
26AR_21572438_ChIP-Seq_LNCaP_Human2.21495977
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14063239
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.11926637
29DROSHA_22980978_ChIP-Seq_HELA_Human2.11088752
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10691897
31SALL1_21062744_ChIP-ChIP_HESCs_Human2.10052636
32TAF15_26573619_Chip-Seq_HEK293_Human2.02024663
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.99592513
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99029820
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.93696066
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.90584466
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.88936365
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85524493
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83867575
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79067646
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72905636
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72136286
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.68189024
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66400272
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.66344199
46SMAD4_21799915_ChIP-Seq_A2780_Human1.64422318
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62248882
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60517554
49P300_19829295_ChIP-Seq_ESCs_Human1.59991813
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.59917239
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59312721
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.58687452
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.56173523
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54747081
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.52852906
56TRIM28_21343339_ChIP-Seq_HEK293_Human1.52732183
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51798220
58* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50741056
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50740688
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.49834878
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49373157
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49269500
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49095965
64FUS_26573619_Chip-Seq_HEK293_Human1.46070165
65ZNF274_21170338_ChIP-Seq_K562_Hela1.46020903
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.41709616
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41112056
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.39723897
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.38873179
70EWS_26573619_Chip-Seq_HEK293_Human1.38177919
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36574235
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34640992
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34390739
74ELK1_19687146_ChIP-ChIP_HELA_Human1.33870232
75CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.32534203
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32466016
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32147488
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31981178
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.31666744
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30607688
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30118848
82SOX2_16153702_ChIP-ChIP_HESCs_Human1.27327232
83NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27322542
84GATA1_26923725_Chip-Seq_HPCs_Mouse1.25855315
85NANOG_16153702_ChIP-ChIP_HESCs_Human1.25108497
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.24545652
87MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23769013
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23752888
89EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23700995
90STAT3_23295773_ChIP-Seq_U87_Human1.23313399
91RNF2_27304074_Chip-Seq_NSC_Mouse1.22391613
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20324239
93NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20146346
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19858889
95AR_25329375_ChIP-Seq_VCAP_Human1.19318667
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19197259
97THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18348995
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17584951
99MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16590454
100SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15083816
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.13929342
102* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13422402
103* ISL1_27105846_Chip-Seq_CPCs_Mouse1.13035521
104TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12923564
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.11865850
106* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11764493
107SMAD_19615063_ChIP-ChIP_OVARY_Human1.11121679
108AR_19668381_ChIP-Seq_PC3_Human1.10944601
109MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10508980
110TBX3_20139965_ChIP-Seq_MESCs_Mouse1.09521209
111TBX3_20139965_ChIP-Seq_ESCs_Mouse1.09304357
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09112475
113YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08721511
114AHR_22903824_ChIP-Seq_MCF-7_Human1.08667557
115HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07437052
116* TCF4_23295773_ChIP-Seq_U87_Human1.07187453
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06631959
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06631959
119GABP_17652178_ChIP-ChIP_JURKAT_Human1.06242867
120CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06152410
121HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06144035
122ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05977079
123SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.05609965
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04808473
125E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03785956
126ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03773208
127P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03530403
128* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02849078
129PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02624450
130* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02301651
131ER_23166858_ChIP-Seq_MCF-7_Human1.02091871
132NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01717039
133SOX17_20123909_ChIP-Seq_XEN_Mouse1.01147162
134RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00735687
135MYC_18358816_ChIP-ChIP_MESCs_Mouse0.99959848
136MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99636369
137TP53_18474530_ChIP-ChIP_U2OS_Human0.99463945
138STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99220747
139* RUNX2_22187159_ChIP-Seq_PCA_Human0.98655963
140VDR_22108803_ChIP-Seq_LS180_Human0.98518074
141CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97121924
142TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96905512
143KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96883208
144DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95731110
145IGF1R_20145208_ChIP-Seq_DFB_Human0.95620968
146TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95584942
147SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95217139
148LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94915147
149EP300_21415370_ChIP-Seq_HL-1_Mouse0.94790666
150* SMAD3_21741376_ChIP-Seq_ESCs_Human0.94470567
151PRDM14_20953172_ChIP-Seq_ESCs_Human0.94308646
152* SOX9_26525672_Chip-Seq_HEART_Mouse0.93537047
153JUN_21703547_ChIP-Seq_K562_Human0.93369208
154MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93094822
155KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.92394702
156KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.92394702
157KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92394702
158TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92214510
159* NANOG_18555785_Chip-Seq_ESCs_Mouse0.91332689
160* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91081683
161* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90869507
162TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.90002610
163SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89530927
164TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89247029
165WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89185273
166MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88832765
167POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86192982

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.01317441
2MP0003635_abnormal_synaptic_transmissio3.66772496
3MP0003880_abnormal_central_pattern3.54436473
4MP0004270_analgesia3.53016840
5MP0009046_muscle_twitch3.31809317
6MP0002064_seizures3.05187480
7MP0010030_abnormal_orbit_morphology3.04078618
8MP0009745_abnormal_behavioral_response3.00490950
9MP0002063_abnormal_learning/memory/cond2.90986177
10MP0003941_abnormal_skin_development2.89231841
11MP0002734_abnormal_mechanical_nocicepti2.67055365
12MP0001486_abnormal_startle_reflex2.66966830
13MP0002272_abnormal_nervous_system2.62916416
14MP0002572_abnormal_emotion/affect_behav2.60872722
15MP0001968_abnormal_touch/_nociception2.60274861
16MP0000537_abnormal_urethra_morphology2.44992196
17MP0005423_abnormal_somatic_nervous2.29463492
18MP0001501_abnormal_sleep_pattern2.18715904
19MP0002736_abnormal_nociception_after2.15794705
20MP0003890_abnormal_embryonic-extraembry2.13911551
21MP0005645_abnormal_hypothalamus_physiol2.13425119
22MP0002234_abnormal_pharynx_morphology2.07643029
23MP0004885_abnormal_endolymph2.06066526
24MP0003329_amyloid_beta_deposits2.05908655
25MP0000778_abnormal_nervous_system1.97816088
26MP0002184_abnormal_innervation1.95359755
27MP0001440_abnormal_grooming_behavior1.95175903
28MP0003937_abnormal_limbs/digits/tail_de1.93418668
29MP0003122_maternal_imprinting1.90549445
30MP0008569_lethality_at_weaning1.90067640
31MP0001293_anophthalmia1.87491594
32MP0002067_abnormal_sensory_capabilities1.86869105
33MP0005646_abnormal_pituitary_gland1.86791051
34MP0002733_abnormal_thermal_nociception1.86233907
35MP0008932_abnormal_embryonic_tissue1.85470785
36MP0002938_white_spotting1.85051588
37MP0002735_abnormal_chemical_nociception1.79520549
38MP0003879_abnormal_hair_cell1.78872035
39MP0001970_abnormal_pain_threshold1.76373830
40MP0009053_abnormal_anal_canal1.75525258
41MP0004858_abnormal_nervous_system1.74481909
42MP0010094_abnormal_chromosome_stability1.73747403
43MP0003705_abnormal_hypodermis_morpholog1.73040768
44MP0001529_abnormal_vocalization1.69643146
45MP0002557_abnormal_social/conspecific_i1.67938263
46MP0002233_abnormal_nose_morphology1.66438019
47MP0002697_abnormal_eye_size1.62571708
48MP0004142_abnormal_muscle_tone1.60307408
49MP0003787_abnormal_imprinting1.59497273
50MP0004924_abnormal_behavior1.58928960
51MP0005386_behavior/neurological_phenoty1.58928960
52MP0006292_abnormal_olfactory_placode1.55842657
53MP0004957_abnormal_blastocyst_morpholog1.52674643
54MP0001485_abnormal_pinna_reflex1.52230935
55MP0000955_abnormal_spinal_cord1.51424322
56MP0002882_abnormal_neuron_morphology1.51104046
57MP0009780_abnormal_chondrocyte_physiolo1.50633845
58MP0000049_abnormal_middle_ear1.50195120
59MP0001286_abnormal_eye_development1.48404903
60MP0006276_abnormal_autonomic_nervous1.48233818
61MP0003119_abnormal_digestive_system1.47296824
62MP0002102_abnormal_ear_morphology1.44095056
63MP0004811_abnormal_neuron_physiology1.43443142
64MP0003385_abnormal_body_wall1.42877942
65MP0001963_abnormal_hearing_physiology1.39024561
66MP0002066_abnormal_motor_capabilities/c1.37098052
67MP0009250_abnormal_appendicular_skeleto1.35040803
68MP0005623_abnormal_meninges_morphology1.34834405
69MP0001984_abnormal_olfaction1.32634643
70MP0003693_abnormal_embryo_hatching1.29845758
71MP0003950_abnormal_plasma_membrane1.29159722
72MP0003136_yellow_coat_color1.29053029
73MP0005257_abnormal_intraocular_pressure1.27486450
74MP0005187_abnormal_penis_morphology1.27139691
75MP0003077_abnormal_cell_cycle1.25835875
76MP0000920_abnormal_myelination1.25529678
77MP0008789_abnormal_olfactory_epithelium1.24990224
78MP0003755_abnormal_palate_morphology1.24194232
79MP0000762_abnormal_tongue_morphology1.23184058
80MP0001905_abnormal_dopamine_level1.22217632
81MP0000428_abnormal_craniofacial_morphol1.20887723
82MP0004272_abnormal_basement_membrane1.20864828
83MP0003690_abnormal_glial_cell1.20384046
84MP0001502_abnormal_circadian_rhythm1.18289128
85MP0002085_abnormal_embryonic_tissue1.18212238
86MP0002084_abnormal_developmental_patter1.17946695
87MP0002152_abnormal_brain_morphology1.15557305
88MP0003634_abnormal_glial_cell1.14571883
89MP0003632_abnormal_nervous_system1.13974981
90MP0000579_abnormal_nail_morphology1.13243250
91MP0003111_abnormal_nucleus_morphology1.12907162
92MP0004742_abnormal_vestibular_system1.12270391
93MP0001299_abnormal_eye_distance/1.12207074
94MP0003718_maternal_effect1.11465859
95MP0003567_abnormal_fetal_cardiomyocyte1.11314245
96MP0003935_abnormal_craniofacial_develop1.10910529
97MP0002160_abnormal_reproductive_system1.09713856
98MP0005503_abnormal_tendon_morphology1.09154003
99MP0003315_abnormal_perineum_morphology1.08866925
100MP0002822_catalepsy1.08603231
101MP0005367_renal/urinary_system_phenotyp1.08566792
102MP0000516_abnormal_urinary_system1.08566792
103MP0005551_abnormal_eye_electrophysiolog1.07448644
104MP0000026_abnormal_inner_ear1.06230681
105MP0010234_abnormal_vibrissa_follicle1.05806787
106MP0000751_myopathy1.05431951
107MP0002092_abnormal_eye_morphology1.05289881
108MP0003631_nervous_system_phenotype1.04246149
109MP0009384_cardiac_valve_regurgitation1.04225076
110MP0002229_neurodegeneration1.03905106
111MP0005380_embryogenesis_phenotype1.03309197
112MP0001672_abnormal_embryogenesis/_devel1.03309197
113MP0002752_abnormal_somatic_nervous1.02340397
114MP0002111_abnormal_tail_morphology1.02237674
115MP0003633_abnormal_nervous_system1.01927221
116MP0004145_abnormal_muscle_electrophysio1.01336669
117MP0001346_abnormal_lacrimal_gland1.01305381
118MP0001177_atelectasis1.00757403
119MP0000566_synostosis1.00702520
120MP0001697_abnormal_embryo_size1.00134377
121MP0008058_abnormal_DNA_repair0.99838847
122MP0000733_abnormal_muscle_development0.97539424
123MP0005394_taste/olfaction_phenotype0.97414588
124MP0005499_abnormal_olfactory_system0.97414588
125MP0000462_abnormal_digestive_system0.97352266
126MP0000631_abnormal_neuroendocrine_gland0.96986369
127MP0002177_abnormal_outer_ear0.95443530
128MP0002909_abnormal_adrenal_gland0.95038132
129MP0005197_abnormal_uvea_morphology0.94170744
130MP0000647_abnormal_sebaceous_gland0.92929463
131MP0004233_abnormal_muscle_weight0.91975884
132MP0000432_abnormal_head_morphology0.91186168
133MP0003121_genomic_imprinting0.91069100
134MP0002282_abnormal_trachea_morphology0.90893663
135MP0003984_embryonic_growth_retardation0.90346571
136MP0002116_abnormal_craniofacial_bone0.89477898
137MP0002088_abnormal_embryonic_growth/wei0.88270409
138MP0002638_abnormal_pupillary_reflex0.86127484
139MP0002837_dystrophic_cardiac_calcinosis0.85810092
140MP0008057_abnormal_DNA_replication0.85744221
141MP0005171_absent_coat_pigmentation0.84896210
142MP0004215_abnormal_myocardial_fiber0.84193893
143MP0004133_heterotaxia0.83168230
144MP0002249_abnormal_larynx_morphology0.82890368
145MP0004134_abnormal_chest_morphology0.82533216
146MP0001849_ear_inflammation0.82148452
147MP0004264_abnormal_extraembryonic_tissu0.80760202
148MP0010352_gastrointestinal_tract_polyps0.80281766
149MP0002932_abnormal_joint_morphology0.79881686
150MP0001340_abnormal_eyelid_morphology0.79750970
151MP0001730_embryonic_growth_arrest0.79268826
152MP0002876_abnormal_thyroid_physiology0.79121497
153MP0000749_muscle_degeneration0.78894229
154MP0003938_abnormal_ear_development0.78277552
155MP0003115_abnormal_respiratory_system0.78060667
156MP0004085_abnormal_heartbeat0.77525646
157MP0006072_abnormal_retinal_apoptosis0.77250859
158MP0002069_abnormal_eating/drinking_beha0.76082859
159MP0003137_abnormal_impulse_conducting0.75997395
160MP0000534_abnormal_ureter_morphology0.75338888
161MP0008872_abnormal_physiological_respon0.73480411
162MP0002751_abnormal_autonomic_nervous0.72491917
163MP0000604_amyloidosis0.72050720
164MP0003123_paternal_imprinting0.70865722
165MP0004036_abnormal_muscle_relaxation0.70656467
166MP0001664_abnormal_digestion0.70080000
167MP0003861_abnormal_nervous_system0.69835600
168MP0001943_abnormal_respiration0.69269204
169MP0005253_abnormal_eye_physiology0.66253750
170MP0002254_reproductive_system_inflammat0.66055830
171MP0003942_abnormal_urinary_system0.65138613
172MP0000013_abnormal_adipose_tissue0.64778060
173MP0002090_abnormal_vision0.63399554
174MP0005248_abnormal_Harderian_gland0.61669464
175MP0003646_muscle_fatigue0.60651344
176MP0008877_abnormal_DNA_methylation0.58538637

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.13835077
2Myokymia (HP:0002411)5.63704498
3Focal seizures (HP:0007359)4.22084013
4Epileptic encephalopathy (HP:0200134)4.08162595
5Progressive cerebellar ataxia (HP:0002073)3.85509554
6Visual hallucinations (HP:0002367)3.84449072
7Atonic seizures (HP:0010819)3.53688259
8Action tremor (HP:0002345)3.47256901
9Impaired vibration sensation in the lower limbs (HP:0002166)3.47105748
10Megalencephaly (HP:0001355)3.46882136
11Bifid tongue (HP:0010297)3.27650831
12Hyperventilation (HP:0002883)3.21501156
13Pheochromocytoma (HP:0002666)3.14601440
14Febrile seizures (HP:0002373)3.14088666
15Aplasia involving bones of the extremities (HP:0009825)3.09784613
16Aplasia involving bones of the upper limbs (HP:0009823)3.09784613
17Aplasia of the phalanges of the hand (HP:0009802)3.09784613
18Absence seizures (HP:0002121)3.09357419
19Broad-based gait (HP:0002136)3.08313207
20Dysdiadochokinesis (HP:0002075)2.97267016
21Generalized tonic-clonic seizures (HP:0002069)2.96374050
22Abnormality of the corticospinal tract (HP:0002492)2.92772834
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.91902387
24Myelomeningocele (HP:0002475)2.87131467
25Ankle clonus (HP:0011448)2.84971552
26Dysmetria (HP:0001310)2.74419077
27Abnormal eating behavior (HP:0100738)2.68477790
28Chromsome breakage (HP:0040012)2.68413749
29Dialeptic seizures (HP:0011146)2.68119351
30Popliteal pterygium (HP:0009756)2.62053858
31Neuroendocrine neoplasm (HP:0100634)2.60393439
32Drooling (HP:0002307)2.53157516
33Excessive salivation (HP:0003781)2.53157516
34Absent septum pellucidum (HP:0001331)2.53081643
35Microglossia (HP:0000171)2.52908190
36Morphological abnormality of the middle ear (HP:0008609)2.51832039
37Diplopia (HP:0000651)2.51656223
38Abnormality of binocular vision (HP:0011514)2.51656223
39Abnormal lung lobation (HP:0002101)2.48792258
40Colon cancer (HP:0003003)2.48347815
41Neurofibrillary tangles (HP:0002185)2.47713830
42Anxiety (HP:0000739)2.47218974
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.44546414
44Degeneration of the lateral corticospinal tracts (HP:0002314)2.44546414
45Abnormality of the septum pellucidum (HP:0007375)2.43799793
46Postural instability (HP:0002172)2.43684419
47Scanning speech (HP:0002168)2.42325359
48Spastic gait (HP:0002064)2.42201452
49Absent speech (HP:0001344)2.40177377
50Genetic anticipation (HP:0003743)2.39923234
51Asymmetry of the thorax (HP:0001555)2.39903251
52Polyphagia (HP:0002591)2.37981513
53Gaze-evoked nystagmus (HP:0000640)2.36803981
54Septo-optic dysplasia (HP:0100842)2.36542684
55Truncal ataxia (HP:0002078)2.36342007
56Insidious onset (HP:0003587)2.36299514
57Termporal pattern (HP:0011008)2.36299514
58Anophthalmia (HP:0000528)2.35209474
59Aplasia of the musculature (HP:0100854)2.35182500
60Supranuclear gaze palsy (HP:0000605)2.32681630
61EEG with generalized epileptiform discharges (HP:0011198)2.31979965
62Epileptiform EEG discharges (HP:0011182)2.31599488
63Depression (HP:0000716)2.31598895
64Gait imbalance (HP:0002141)2.30415578
65Urinary bladder sphincter dysfunction (HP:0002839)2.28143979
66Pterygium (HP:0001059)2.27777285
67Hypsarrhythmia (HP:0002521)2.26860963
68Bicornuate uterus (HP:0000813)2.23730563
69Cerebral inclusion bodies (HP:0100314)2.22620149
70Poor eye contact (HP:0000817)2.22396995
71Akinesia (HP:0002304)2.22252516
72Aplasia/Hypoplasia of the sternum (HP:0006714)2.22133997
73Facial cleft (HP:0002006)2.20178592
74Type 2 muscle fiber atrophy (HP:0003554)2.17078985
75Bilateral microphthalmos (HP:0007633)2.16670816
76Hemiparesis (HP:0001269)2.16597815
77Hypoplastic pelvis (HP:0008839)2.16224368
78Alacrima (HP:0000522)2.14401385
79Fetal akinesia sequence (HP:0001989)2.14086585
80Progressive inability to walk (HP:0002505)2.13772576
81Lower limb muscle weakness (HP:0007340)2.13636281
82Impaired social interactions (HP:0000735)2.12212950
83Abnormal social behavior (HP:0012433)2.12212950
84Mutism (HP:0002300)2.12164595
85Specific learning disability (HP:0001328)2.12127590
86Urinary urgency (HP:0000012)2.10903877
87Amniotic constriction ring (HP:0009775)2.05170564
88Abnormality of placental membranes (HP:0011409)2.05170564
89Intention tremor (HP:0002080)2.04098515
90Impaired vibratory sensation (HP:0002495)2.03121438
91High anterior hairline (HP:0009890)2.02367567
92Abnormal hair whorl (HP:0010721)2.01851164
93Peripheral hypomyelination (HP:0007182)2.01718589
94Hyperthyroidism (HP:0000836)2.01409280
95Abnormality of the umbilical cord (HP:0010881)1.93057196
96Vaginal atresia (HP:0000148)1.92440449
97Narrow nasal bridge (HP:0000446)1.92077395
98Genital tract atresia (HP:0001827)1.92038317
99Neoplasm of the peripheral nervous system (HP:0100007)1.90279442
100Congenital primary aphakia (HP:0007707)1.90018672
101Limb dystonia (HP:0002451)1.87496785
102Proximal tubulopathy (HP:0000114)1.87387689
103Neuronal loss in central nervous system (HP:0002529)1.85939334
104Muscle fiber atrophy (HP:0100295)1.85375467
105Hemiplegia (HP:0002301)1.85018019
106Cutaneous finger syndactyly (HP:0010554)1.83598321
107Duplication of thumb phalanx (HP:0009942)1.83393269
108Absent eyebrow (HP:0002223)1.82779735
109Bradykinesia (HP:0002067)1.82718739
110Midline defect of the nose (HP:0004122)1.81358095
111Blue irides (HP:0000635)1.81338186
112Embryonal renal neoplasm (HP:0011794)1.81278854
113Cortical dysplasia (HP:0002539)1.78707416
114Medial flaring of the eyebrow (HP:0010747)1.77386952
115Bell-shaped thorax (HP:0001591)1.76400970
116Generalized myoclonic seizures (HP:0002123)1.75950882
117Increased nuchal translucency (HP:0010880)1.75375389
118Vitreoretinal degeneration (HP:0000655)1.75374985
119Abnormality of the fetal cardiovascular system (HP:0010948)1.74209021
120Abnormal umbilical cord blood vessels (HP:0011403)1.74209021
121Single umbilical artery (HP:0001195)1.74209021
122Meckel diverticulum (HP:0002245)1.74032477
123Renal hypoplasia (HP:0000089)1.73174893
124Abnormality of salivation (HP:0100755)1.72762842
125Partial duplication of the phalanx of hand (HP:0009999)1.72161831
126Abnormalities of placenta or umbilical cord (HP:0001194)1.71958143
127Poor suck (HP:0002033)1.71918601
128Nephrogenic diabetes insipidus (HP:0009806)1.71017705
129Synostosis involving the elbow (HP:0003938)1.70745608
130Humeroradial synostosis (HP:0003041)1.70745608
131Papilledema (HP:0001085)1.69871851
132Maternal diabetes (HP:0009800)1.69857363
133Abnormality of the phalanges of the hallux (HP:0010057)1.69740948
134Abnormality of saccadic eye movements (HP:0000570)1.68848894
135Morphological abnormality of the pyramidal tract (HP:0002062)1.68817346
136Partial duplication of thumb phalanx (HP:0009944)1.68640221
137Abnormality of the labia minora (HP:0012880)1.68503641
138Amblyopia (HP:0000646)1.67766612
139Agitation (HP:0000713)1.67135519
140Nephroblastoma (Wilms tumor) (HP:0002667)1.66969266
141Aqueductal stenosis (HP:0002410)1.66922060
142Aplasia/Hypoplasia of the uvula (HP:0010293)1.66744380
143Torticollis (HP:0000473)1.66596221
144Focal dystonia (HP:0004373)1.65735346
145Abnormality of chromosome stability (HP:0003220)1.65426210
146Decreased lacrimation (HP:0000633)1.64700474
147Postural tremor (HP:0002174)1.64282511
148Sleep apnea (HP:0010535)1.63667392
149Hypoplastic heart (HP:0001961)1.63472199
150Cutaneous syndactyly (HP:0012725)1.63375544
151Truncus arteriosus (HP:0001660)1.63365864
152Abnormality of the lacrimal duct (HP:0011481)1.63339801
153Reticulocytopenia (HP:0001896)1.63245793
154Thin ribs (HP:0000883)1.61951317
155Abnormality of the ileum (HP:0001549)1.61536990
156Ectopic anus (HP:0004397)1.60083574
157Uterine leiomyosarcoma (HP:0002891)1.59467904
158Leiomyosarcoma (HP:0100243)1.59467904
159Medulloblastoma (HP:0002885)1.58745927
160Premature rupture of membranes (HP:0001788)1.58379629
161Abnormality of the nasolacrimal system (HP:0000614)1.58248038
162Omphalocele (HP:0001539)1.56376959
163Overriding aorta (HP:0002623)1.55663015
164Triphalangeal thumb (HP:0001199)1.55373465
165Renal duplication (HP:0000075)1.54435573
166Abnormality of the carotid arteries (HP:0005344)1.53383658
167Malignant gastrointestinal tract tumors (HP:0006749)1.53211604
168Gastrointestinal carcinoma (HP:0002672)1.53211604
169Coronal craniosynostosis (HP:0004440)1.53149876
170Abnormality of the aortic arch (HP:0012303)1.52939600
171Breast carcinoma (HP:0003002)1.52869341
172Aplasia/Hypoplasia of the tongue (HP:0010295)1.52353023
173Aplasia/Hypoplasia involving the musculature (HP:0001460)1.51516713
174Partial agenesis of the corpus callosum (HP:0001338)1.50605084
175Ankle contracture (HP:0006466)1.50275773
176Ectopic kidney (HP:0000086)1.49476510
177Glioma (HP:0009733)1.49116573
178Arterial tortuosity (HP:0005116)1.48389646
179Transitional cell carcinoma of the bladder (HP:0006740)1.47575957
180Dental crowding (HP:0000678)1.47566965
181Choanal stenosis (HP:0000452)1.47148701
182Stenosis of the external auditory canal (HP:0000402)1.46770351
183Atresia of the external auditory canal (HP:0000413)1.46095875
184Absent eyelashes (HP:0000561)1.45836451
185Absent radius (HP:0003974)1.45509796
186Intellectual disability, moderate (HP:0002342)1.44469846
187Intrahepatic cholestasis (HP:0001406)1.44449301
188Cystic hygroma (HP:0000476)1.43866631
189Volvulus (HP:0002580)1.42952799
190Decreased muscle mass (HP:0003199)1.42797760
191Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.42745221
192Small intestinal stenosis (HP:0012848)1.39890797
193Duodenal stenosis (HP:0100867)1.39890797
194Soft skin (HP:0000977)1.39347265
195Birth length less than 3rd percentile (HP:0003561)1.39113418
196Congenital malformation of the right heart (HP:0011723)1.38923771
197Double outlet right ventricle (HP:0001719)1.38923771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.78651471
2MAP3K43.45268580
3MAP3K93.38549448
4EPHA43.02251048
5MARK12.98059343
6PLK42.87824824
7MAP2K72.63898027
8TRIM282.60613348
9CASK2.54191993
10MUSK2.51977402
11MINK12.49441738
12NTRK22.36684716
13CDC72.34457401
14PBK2.20764190
15WEE12.18349997
16SRPK12.01317836
17STK162.00537868
18PRKD31.99236458
19MAP3K121.94183783
20TNIK1.92641915
21VRK21.89108317
22MAP2K41.88938056
23BUB11.88476762
24PIK3CA1.87776679
25DAPK21.84361168
26PLK21.80216261
27TAF11.76369829
28LMTK21.74492436
29KSR21.74155078
30PAK61.73442934
31TTK1.71968155
32MAPK131.66035802
33OXSR11.58615095
34PLK31.57998742
35PHKG21.51293911
36PHKG11.51293911
37LATS11.50347940
38PRPF4B1.48445950
39MET1.46854498
40CDK51.44952137
41TYRO31.44175014
42KSR11.43870111
43PAK41.43576970
44CDK191.42352767
45NTRK11.31826985
46PKN21.31317769
47PNCK1.29138404
48NUAK11.25912577
49EIF2AK11.25373076
50EPHB21.23102818
51PLK11.20980630
52GRK51.20494404
53SGK2231.20471248
54SGK4941.20471248
55TESK11.19105590
56STK391.18249419
57CAMKK11.18058001
58PRKCG1.16888521
59STK38L1.16743312
60CSNK1G11.16175022
61UHMK11.15443314
62MYLK1.11238821
63LATS21.11104290
64CAMK2A1.05489613
65MAP3K101.05111699
66MST41.03175563
67ARAF1.03167321
68MKNK10.97938043
69LIMK10.97668644
70ERBB30.97334083
71EPHA20.96686783
72CAMKK20.95493928
73NME10.94962208
74CDK140.94066501
75PDGFRA0.93963549
76MKNK20.93409200
77EIF2AK20.92496901
78SGK20.91270718
79MAP3K20.91201793
80CDK180.89342501
81BRSK10.88687155
82CAMK2B0.88261032
83CDK150.87644333
84DAPK10.87080434
85DDR20.85866966
86FES0.84598791
87AURKB0.84547068
88MST1R0.84157671
89CHEK20.83414876
90PTK20.83075668
91VRK10.82558167
92DYRK1A0.82496885
93CSNK1G20.81588682
94MAP3K130.80532544
95WNK30.79806367
96ROCK20.79670056
97CDK70.79011957
98PAK30.77010982
99BCR0.76126301
100EIF2AK30.75104066
101CDK11A0.74942234
102FGR0.74734951
103BMPR20.73587729
104MELK0.72658136
105PRKCH0.72295064
106PTK2B0.71287548
107ILK0.70136370
108PDK40.69175730
109PDK30.69175730
110SGK30.68120358
111STK380.67122480
112NEK60.66703479
113BRAF0.66557867
114MAP3K60.66188248
115PINK10.66170712
116NEK20.65876787
117DYRK30.65402847
118ZAK0.65142584
119DYRK20.65101305
120SGK10.64502267
121SIK30.64430340
122CAMK2D0.64060854
123DMPK0.62683925
124CAMK10.61374875
125CAMK2G0.60994113
126PKN10.60272824
127RPS6KB20.60212679
128AURKA0.59668204
129PASK0.59136312
130BCKDK0.58612398
131RIPK40.58214022
132SCYL20.57982168
133RET0.57022102
134PRKCE0.55637425
135CAMK1G0.55615539
136FER0.55274819
137WNK10.54952382
138ALK0.54267394
139SIK20.53805519
140FGFR20.53741623
141CDC42BPA0.52508013
142ATR0.52197654
143STK110.50863762
144MARK20.50823639
145BRSK20.49462384
146CSNK1G30.48809370
147FGFR10.48680657
148FYN0.48565825
149OBSCN0.47821861
150NEK10.47089721
151ROCK10.46612239
152RPS6KA30.43868770
153CHEK10.43808557
154BMPR1B0.43729512
155CDK80.43724589
156CSNK1A1L0.43308181
157WNK40.42717559
158PDK10.41025702
159IRAK20.40772904
160TSSK60.39889899
161ERBB40.38040243
162PDPK10.37615764
163ADRBK10.37166848
164AKT30.36846866
165PDK20.36633461

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.62422056
2Synaptic vesicle cycle_Homo sapiens_hsa047213.26294817
3GABAergic synapse_Homo sapiens_hsa047272.74220233
4Mismatch repair_Homo sapiens_hsa034302.71473114
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56415342
6Glutamatergic synapse_Homo sapiens_hsa047242.50041750
7DNA replication_Homo sapiens_hsa030302.45815938
8Olfactory transduction_Homo sapiens_hsa047402.38900729
9Circadian entrainment_Homo sapiens_hsa047132.38655432
10Morphine addiction_Homo sapiens_hsa050322.29503761
11Long-term potentiation_Homo sapiens_hsa047202.26891789
12Amphetamine addiction_Homo sapiens_hsa050312.16073040
13Collecting duct acid secretion_Homo sapiens_hsa049662.12123575
14Fanconi anemia pathway_Homo sapiens_hsa034602.02737001
15Cell cycle_Homo sapiens_hsa041101.99566954
16Salivary secretion_Homo sapiens_hsa049701.99499182
17Homologous recombination_Homo sapiens_hsa034401.98240377
18Nitrogen metabolism_Homo sapiens_hsa009101.98121238
19Dopaminergic synapse_Homo sapiens_hsa047281.87541140
20Insulin secretion_Homo sapiens_hsa049111.81121791
21Gastric acid secretion_Homo sapiens_hsa049711.80915367
22Long-term depression_Homo sapiens_hsa047301.78829035
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78077904
24Proteasome_Homo sapiens_hsa030501.75962461
25Cholinergic synapse_Homo sapiens_hsa047251.70553338
26Non-homologous end-joining_Homo sapiens_hsa034501.68934685
27Taste transduction_Homo sapiens_hsa047421.68811558
28Sulfur relay system_Homo sapiens_hsa041221.67030772
29Folate biosynthesis_Homo sapiens_hsa007901.66113750
30Serotonergic synapse_Homo sapiens_hsa047261.65468368
31Nucleotide excision repair_Homo sapiens_hsa034201.61931212
32Base excision repair_Homo sapiens_hsa034101.60766275
33Cocaine addiction_Homo sapiens_hsa050301.60709228
34Steroid biosynthesis_Homo sapiens_hsa001001.59831026
35RNA transport_Homo sapiens_hsa030131.56752171
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56585215
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54791545
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.54080101
39Adherens junction_Homo sapiens_hsa045201.48800606
40Vibrio cholerae infection_Homo sapiens_hsa051101.47734512
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46958989
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46716214
43Cardiac muscle contraction_Homo sapiens_hsa042601.46167187
44Renin secretion_Homo sapiens_hsa049241.40440491
45Oxidative phosphorylation_Homo sapiens_hsa001901.40282762
46Calcium signaling pathway_Homo sapiens_hsa040201.37151690
47Axon guidance_Homo sapiens_hsa043601.35585748
48Basal transcription factors_Homo sapiens_hsa030221.33048261
49Oxytocin signaling pathway_Homo sapiens_hsa049211.32640211
50Gap junction_Homo sapiens_hsa045401.30003253
51TGF-beta signaling pathway_Homo sapiens_hsa043501.29892452
52Thyroid cancer_Homo sapiens_hsa052161.29133115
53Vitamin B6 metabolism_Homo sapiens_hsa007501.28454746
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.25806313
55p53 signaling pathway_Homo sapiens_hsa041151.22341478
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21811723
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.20268454
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16148607
59Spliceosome_Homo sapiens_hsa030401.15134746
60GnRH signaling pathway_Homo sapiens_hsa049121.14759528
61Melanogenesis_Homo sapiens_hsa049161.12585175
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.12311355
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11797897
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07881792
65cAMP signaling pathway_Homo sapiens_hsa040241.04909673
66Biosynthesis of amino acids_Homo sapiens_hsa012301.01107731
67Propanoate metabolism_Homo sapiens_hsa006401.01008922
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00479126
69Parkinsons disease_Homo sapiens_hsa050121.00132634
70Alzheimers disease_Homo sapiens_hsa050100.99017063
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97962681
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97892819
73Estrogen signaling pathway_Homo sapiens_hsa049150.97809194
74ErbB signaling pathway_Homo sapiens_hsa040120.96776178
75Ribosome_Homo sapiens_hsa030100.96387451
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96307779
77Pyruvate metabolism_Homo sapiens_hsa006200.95927621
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95775503
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95432576
80Dilated cardiomyopathy_Homo sapiens_hsa054140.93278050
81Pancreatic secretion_Homo sapiens_hsa049720.92478494
82Fatty acid elongation_Homo sapiens_hsa000620.91985075
83Pyrimidine metabolism_Homo sapiens_hsa002400.91202635
84mRNA surveillance pathway_Homo sapiens_hsa030150.90583991
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89537754
86Protein export_Homo sapiens_hsa030600.88488459
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85827748
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83574277
89Oocyte meiosis_Homo sapiens_hsa041140.83404300
90RNA polymerase_Homo sapiens_hsa030200.82730736
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82159256
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81222268
93Phototransduction_Homo sapiens_hsa047440.79976031
94ECM-receptor interaction_Homo sapiens_hsa045120.79909713
95Glioma_Homo sapiens_hsa052140.79525513
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78895611
97Butanoate metabolism_Homo sapiens_hsa006500.78773526
98Thyroid hormone synthesis_Homo sapiens_hsa049180.78762945
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78701347
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.75981617
101MicroRNAs in cancer_Homo sapiens_hsa052060.74955715
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73943570
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73752697
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.72738069
105Type II diabetes mellitus_Homo sapiens_hsa049300.71221034
106Proteoglycans in cancer_Homo sapiens_hsa052050.71054504
107RNA degradation_Homo sapiens_hsa030180.70998817
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70776878
109Fatty acid biosynthesis_Homo sapiens_hsa000610.70324256
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69619707
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.68562945
112Wnt signaling pathway_Homo sapiens_hsa043100.67544953
113Carbon metabolism_Homo sapiens_hsa012000.66215816
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65670280
115Glutathione metabolism_Homo sapiens_hsa004800.61756346
116Focal adhesion_Homo sapiens_hsa045100.61075831
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59918730
118Huntingtons disease_Homo sapiens_hsa050160.59660025
119Dorso-ventral axis formation_Homo sapiens_hsa043200.59369197
120Choline metabolism in cancer_Homo sapiens_hsa052310.58752382
121MAPK signaling pathway_Homo sapiens_hsa040100.58570624
122Purine metabolism_Homo sapiens_hsa002300.58242711
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57075811
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55985920
125Ras signaling pathway_Homo sapiens_hsa040140.55822425
126Tight junction_Homo sapiens_hsa045300.54936283
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54919712
128One carbon pool by folate_Homo sapiens_hsa006700.54889396
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54160964
130Hedgehog signaling pathway_Homo sapiens_hsa043400.53581388
131Renal cell carcinoma_Homo sapiens_hsa052110.52353697
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52091732
133Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50798179
134Arginine and proline metabolism_Homo sapiens_hsa003300.50166003
135Selenocompound metabolism_Homo sapiens_hsa004500.50122742
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48337798
137Pathways in cancer_Homo sapiens_hsa052000.47624407
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47387506
139Hippo signaling pathway_Homo sapiens_hsa043900.47123842
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46810275
141Rap1 signaling pathway_Homo sapiens_hsa040150.46754385
142Glucagon signaling pathway_Homo sapiens_hsa049220.45884894
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45057898
144Small cell lung cancer_Homo sapiens_hsa052220.44983115
145Basal cell carcinoma_Homo sapiens_hsa052170.43924168
146Sulfur metabolism_Homo sapiens_hsa009200.43852434
147Prostate cancer_Homo sapiens_hsa052150.41801842
148Prion diseases_Homo sapiens_hsa050200.40879791
149Pentose phosphate pathway_Homo sapiens_hsa000300.40650728
150Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40003051
151Lysine degradation_Homo sapiens_hsa003100.39933415
152Ether lipid metabolism_Homo sapiens_hsa005650.39627623
153N-Glycan biosynthesis_Homo sapiens_hsa005100.39321675
154Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39316003
155Sphingolipid signaling pathway_Homo sapiens_hsa040710.39223943
156Circadian rhythm_Homo sapiens_hsa047100.38806270
157Endometrial cancer_Homo sapiens_hsa052130.37375608
158Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36787141
159Rheumatoid arthritis_Homo sapiens_hsa053230.36669989
160Type I diabetes mellitus_Homo sapiens_hsa049400.36116162
161Alcoholism_Homo sapiens_hsa050340.34818876
162Melanoma_Homo sapiens_hsa052180.34764563
163Bile secretion_Homo sapiens_hsa049760.32874997
164Colorectal cancer_Homo sapiens_hsa052100.32266839
165Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31366343

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