LYPD6B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)6.49157028
2desmosome organization (GO:0002934)6.11973257
3bundle of His cell to Purkinje myocyte communication (GO:0086069)5.82700816
4establishment of skin barrier (GO:0061436)5.55859084
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.41219321
6cilium or flagellum-dependent cell motility (GO:0001539)5.33558654
7positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.15218088
8cilium movement (GO:0003341)5.14965553
9vocalization behavior (GO:0071625)5.06201916
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.02320589
11Golgi transport vesicle coating (GO:0048200)4.94555341
12COPI coating of Golgi vesicle (GO:0048205)4.94555341
13regulation of water loss via skin (GO:0033561)4.90593679
14synaptic vesicle exocytosis (GO:0016079)4.84083487
15keratinocyte development (GO:0003334)4.56039128
16establishment of apical/basal cell polarity (GO:0035089)4.55546989
17regulation of glutamate receptor signaling pathway (GO:1900449)4.47605541
18epithelial cilium movement (GO:0003351)4.41716861
19glutamate secretion (GO:0014047)4.38757976
20keratinocyte proliferation (GO:0043616)4.35597172
21regulation of keratinocyte differentiation (GO:0045616)4.30846975
22neuronal action potential propagation (GO:0019227)4.26804206
23synaptic vesicle maturation (GO:0016188)4.15707412
24regulation of synaptic vesicle exocytosis (GO:2000300)4.15472594
25motile cilium assembly (GO:0044458)4.13502777
26long-chain fatty acid biosynthetic process (GO:0042759)4.10170692
27keratinization (GO:0031424)4.07657219
28regulation of short-term neuronal synaptic plasticity (GO:0048172)4.06280462
29negative regulation of transcription by competitive promoter binding (GO:0010944)4.02327851
30calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.97416023
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.96761602
32ATP hydrolysis coupled proton transport (GO:0015991)3.95783307
33energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.95783307
34regulation of transforming growth factor beta2 production (GO:0032909)3.95084114
35diterpenoid biosynthetic process (GO:0016102)3.90804746
36primary alcohol catabolic process (GO:0034310)3.90661271
37neuron cell-cell adhesion (GO:0007158)3.89782658
38negative regulation of epidermal cell differentiation (GO:0045605)3.88916232
39hemidesmosome assembly (GO:0031581)3.88846555
40positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.85945605
41hair cycle (GO:0042633)3.84452738
42molting cycle (GO:0042303)3.84452738
43regulation of keratinocyte proliferation (GO:0010837)3.82910289
44neurotransmitter secretion (GO:0007269)3.80697697
45transferrin transport (GO:0033572)3.77463053
46intestinal epithelial cell development (GO:0060576)3.73528125
47regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.73464616
48regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.73464616
49regulation of neurotransmitter uptake (GO:0051580)3.69953109
50polarized epithelial cell differentiation (GO:0030859)3.68639401
51negative regulation of keratinocyte proliferation (GO:0010839)3.68496815
52regulation of cardioblast differentiation (GO:0051890)3.66104248
53tight junction assembly (GO:0070830)3.64520077
54establishment or maintenance of monopolar cell polarity (GO:0061339)3.62829881
55establishment of monopolar cell polarity (GO:0061162)3.62829881
56negative regulation of epidermis development (GO:0045683)3.62215653
57positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.58127671
58negative regulation of synaptic transmission, GABAergic (GO:0032229)3.53822635
59positive regulation of synaptic transmission, GABAergic (GO:0032230)3.53360155
60ferric iron transport (GO:0015682)3.53314465
61trivalent inorganic cation transport (GO:0072512)3.53314465
62regulation of synaptic vesicle transport (GO:1902803)3.52209047
63neuron-neuron synaptic transmission (GO:0007270)3.51727245
64positive regulation of neurotransmitter transport (GO:0051590)3.47459530
65multicellular organismal water homeostasis (GO:0050891)3.46279076
66regulation of transforming growth factor beta1 production (GO:0032908)3.45176171
67synaptic vesicle docking involved in exocytosis (GO:0016081)3.44854283
68ear development (GO:0043583)3.44234420
69ionotropic glutamate receptor signaling pathway (GO:0035235)3.43050974
70proteasome assembly (GO:0043248)3.42603319
71negative regulation of lipase activity (GO:0060192)3.42533294
72regulation of synaptic transmission, dopaminergic (GO:0032225)3.41516584
73protein localization to synapse (GO:0035418)3.41307088
74regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.36163877
75gamma-aminobutyric acid transport (GO:0015812)3.33737103
76pyrimidine-containing compound transmembrane transport (GO:0072531)3.23772353
77positive regulation of Cdc42 GTPase activity (GO:0043089)3.23180153
78positive regulation of transforming growth factor beta production (GO:0071636)3.22031826
79thyroid hormone generation (GO:0006590)3.21863946
80vesicle transport along microtubule (GO:0047496)3.21494472
81establishment of planar polarity (GO:0001736)3.20431461
82establishment of tissue polarity (GO:0007164)3.20431461
83regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.19805714
84aggressive behavior (GO:0002118)3.17304139
85terpenoid biosynthetic process (GO:0016114)3.15661901
86proline transport (GO:0015824)3.13654468
87negative regulation of membrane potential (GO:0045837)3.12583980
88synaptic transmission, dopaminergic (GO:0001963)3.10706029
89intermediate filament organization (GO:0045109)3.10579769
90left/right pattern formation (GO:0060972)3.09356507
91vitamin transmembrane transport (GO:0035461)3.08990163
92glutamate receptor signaling pathway (GO:0007215)3.07888226
93regulation of ruffle assembly (GO:1900027)3.05742709
94layer formation in cerebral cortex (GO:0021819)3.04603717
95dendritic spine morphogenesis (GO:0060997)3.04501901
96synaptic transmission, glutamatergic (GO:0035249)3.04051146
97cerebellar Purkinje cell differentiation (GO:0021702)3.03556256
98gamma-aminobutyric acid signaling pathway (GO:0007214)3.01878056
99regulation of cholesterol esterification (GO:0010872)2.99976900
100regulation of synaptic transmission, GABAergic (GO:0032228)2.98528691
101neurotransmitter transport (GO:0006836)2.98136234
102regulation of long-term neuronal synaptic plasticity (GO:0048169)2.97978651
103exploration behavior (GO:0035640)2.95949404
104cell migration in hindbrain (GO:0021535)2.95123759
105cell-cell junction assembly (GO:0007043)2.94735741
106phagosome maturation (GO:0090382)2.94020244
107exogenous drug catabolic process (GO:0042738)2.90770593
108gap junction assembly (GO:0016264)2.90646546
109locomotory exploration behavior (GO:0035641)2.90488754
110establishment or maintenance of bipolar cell polarity (GO:0061245)2.90255280
111establishment or maintenance of apical/basal cell polarity (GO:0035088)2.90255280
112membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.88296765
113ventricular cardiac muscle cell action potential (GO:0086005)2.87990618
114glutathione derivative metabolic process (GO:1901685)2.87304678
115glutathione derivative biosynthetic process (GO:1901687)2.87304678
116dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.85640620
117peptidyl-cysteine modification (GO:0018198)2.85149125
118behavioral response to ethanol (GO:0048149)2.84156906
119maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.83114954
120water homeostasis (GO:0030104)2.82868875
121neuromuscular process controlling posture (GO:0050884)2.82513676
122paraxial mesoderm development (GO:0048339)2.82277396
123long-term synaptic potentiation (GO:0060291)2.82106940
124regulation of neuronal synaptic plasticity (GO:0048168)2.81463297
125phospholipid efflux (GO:0033700)2.81308338
126regulation of epidermal cell differentiation (GO:0045604)2.81302623
127fatty acid elongation (GO:0030497)2.80370969
128positive regulation of keratinocyte differentiation (GO:0045618)2.79479510
129sphingoid metabolic process (GO:0046519)2.77841139
130negative regulation of dendrite morphogenesis (GO:0050774)2.76709448
131regulation of neurotransmitter levels (GO:0001505)2.76534630
132postsynaptic membrane organization (GO:0001941)2.76512367
133negative regulation of T cell differentiation in thymus (GO:0033085)2.76327858
134regulation of vesicle fusion (GO:0031338)2.76327529
135cellular potassium ion homeostasis (GO:0030007)2.75820593
136G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.75738770
137keratinocyte differentiation (GO:0030216)2.74170581
138cardiac right ventricle morphogenesis (GO:0003215)2.72812826
139regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.71615582
140neurotransmitter-gated ion channel clustering (GO:0072578)2.70934106
141regulation of neurotransmitter transport (GO:0051588)2.70401460
142positive regulation of sodium ion transport (GO:0010765)2.70016536
143presynaptic membrane assembly (GO:0097105)2.69613393
144calcium-mediated signaling using intracellular calcium source (GO:0035584)2.69467498
145positive regulation of amine transport (GO:0051954)2.69020062
146embryonic camera-type eye development (GO:0031076)2.68478942
147regulation of cellular amino acid metabolic process (GO:0006521)2.67454265
148neuron recognition (GO:0008038)2.67450097
149regulation of sodium ion transmembrane transporter activity (GO:2000649)2.66762399
150retinoic acid metabolic process (GO:0042573)2.65926827
151synaptic transmission (GO:0007268)2.65415881
152protein autoprocessing (GO:0016540)2.65223680
153organelle transport along microtubule (GO:0072384)2.65038970
154positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.64988848
155positive regulation of mitochondrial membrane permeability (GO:0035794)2.63879734
156positive regulation of epidermal cell differentiation (GO:0045606)2.63857791
157lung epithelium development (GO:0060428)2.63842007
158positive regulation of vesicle fusion (GO:0031340)2.63433875
159positive regulation of action potential (GO:0045760)2.62992301
160mating behavior (GO:0007617)2.62973019
161galactose metabolic process (GO:0006012)2.62038244
162morphogenesis of embryonic epithelium (GO:0016331)2.60227506
163axoneme assembly (GO:0035082)2.58891488
164protein retention in ER lumen (GO:0006621)2.58104272
165negative regulation of digestive system process (GO:0060457)2.56534315
166epithelial cell-cell adhesion (GO:0090136)2.56495872
167morphogenesis of an epithelial fold (GO:0060571)2.55366035
168atrioventricular valve morphogenesis (GO:0003181)2.55353817
169uterus development (GO:0060065)2.55187355
170lateral sprouting from an epithelium (GO:0060601)2.53634424
171glandular epithelial cell differentiation (GO:0002067)2.52826199
172UDP-N-acetylglucosamine metabolic process (GO:0006047)2.49402846
173regulation of cytokine secretion involved in immune response (GO:0002739)2.48179084
174embryonic cranial skeleton morphogenesis (GO:0048701)2.45477692
175lung secretory cell differentiation (GO:0061140)2.42996634
176establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.42604193
177positive regulation of cell size (GO:0045793)2.42181988
178regulation of epidermis development (GO:0045682)2.40333530
179valine metabolic process (GO:0006573)2.39337344
180regulation of substrate adhesion-dependent cell spreading (GO:1900024)2.39123688
181negative regulation of kidney development (GO:0090185)2.38417156
182regulation of hippo signaling (GO:0035330)2.38129680
183protein maturation by protein folding (GO:0022417)2.37236347
184retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.36472481
185regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.36412985
186negative regulation of stem cell proliferation (GO:2000647)2.35729630
187muscle atrophy (GO:0014889)2.35055951
188left/right axis specification (GO:0070986)2.34631062
189positive regulation of translational initiation (GO:0045948)2.34414572
190COPII vesicle coating (GO:0048208)2.33057394
191membrane budding (GO:0006900)2.32882105
192positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.32440676
193negative regulation of chondrocyte differentiation (GO:0032331)2.32184356

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.63117920
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.27226485
3ESR1_21235772_ChIP-Seq_MCF-7_Human4.23429791
4ESR1_20079471_ChIP-ChIP_T-47D_Human3.84244764
5EZH2_22144423_ChIP-Seq_EOC_Human3.66345604
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.50444476
7GBX2_23144817_ChIP-Seq_PC3_Human3.24427750
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92545027
9TAF15_26573619_Chip-Seq_HEK293_Human2.90358941
10* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.81821332
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71331969
12ESR1_15608294_ChIP-ChIP_MCF-7_Human2.63704102
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.62116986
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52167199
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52156294
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52156294
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.51213471
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50267386
19HIF1A_21447827_ChIP-Seq_MCF-7_Human2.48673995
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45711255
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.42242501
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38173447
23GATA3_24758297_ChIP-Seq_MCF-7_Human2.35483421
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32487318
25AR_21572438_ChIP-Seq_LNCaP_Human2.31714033
26AR_21909140_ChIP-Seq_LNCAP_Human2.30622780
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19844086
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.17045973
29MTF2_20144788_ChIP-Seq_MESCs_Mouse2.15511572
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.07980416
31CDX2_20551321_ChIP-Seq_CACO-2_Human2.07499047
32SOX2_20726797_ChIP-Seq_SW620_Human2.01979824
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.98565376
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.96586481
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94439136
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.92234155
37* REST_21632747_ChIP-Seq_MESCs_Mouse1.89262525
38ELF5_23300383_ChIP-Seq_T47D_Human1.89141751
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88894401
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87282773
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.83808991
42FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.83534918
43DROSHA_22980978_ChIP-Seq_HELA_Human1.83098449
44P63_26484246_Chip-Seq_KERATINOCYTES_Human1.82814946
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82788314
46HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.82645951
47SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.80518385
48SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.80518385
49GATA4_25053715_ChIP-Seq_YYC3_Human1.80449409
50RUNX1_27514584_Chip-Seq_MCF-7_Human1.79712365
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76825013
52RACK7_27058665_Chip-Seq_MCF-7_Human1.75333181
53GATA6_25053715_ChIP-Seq_YYC3_Human1.74901005
54SOX2_27498859_Chip-Seq_STOMACH_Mouse1.72936813
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71717111
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71023767
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69081111
58VDR_22108803_ChIP-Seq_LS180_Human1.68449806
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.67856088
60ZNF263_19887448_ChIP-Seq_K562_Human1.64144938
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62579011
62* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62116971
63FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.59008356
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58249531
65* AHR_22903824_ChIP-Seq_MCF-7_Human1.55670424
66SMAD4_21799915_ChIP-Seq_A2780_Human1.55119442
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54948169
68* KLF5_25053715_ChIP-Seq_YYC3_Human1.54933447
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52445711
70ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51579977
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.51505532
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.50490134
73* P300_19829295_ChIP-Seq_ESCs_Human1.47052221
74RNF2_27304074_Chip-Seq_NSC_Mouse1.46810862
75TP53_18474530_ChIP-ChIP_U2OS_Human1.46098378
76GABP_17652178_ChIP-ChIP_JURKAT_Human1.45729024
77JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.45602364
78AR_25329375_ChIP-Seq_VCAP_Human1.44090532
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.42589630
80RARB_27405468_Chip-Seq_BRAIN_Mouse1.41701162
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.40799824
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.39805849
83* ARNT_22903824_ChIP-Seq_MCF-7_Human1.38981249
84ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.38046542
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37163936
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34110939
87* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32371379
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31732684
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30031650
90EOMES_21245162_ChIP-Seq_HESCs_Human1.29776413
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29678337
92BCAT_22108803_ChIP-Seq_LS180_Human1.26536505
93ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26428288
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25121925
95TCF4_18268006_ChIP-ChIP_LS174T_Human1.22475220
96EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.21823404
97PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21277477
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.17994208
99SOX2_21211035_ChIP-Seq_LN229_Gbm1.17898614
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16156613
101DCP1A_22483619_ChIP-Seq_HELA_Human1.16043774
102RING1B_27294783_Chip-Seq_ESCs_Mouse1.15894212
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15572092
104POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14760685
105ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.14240762
106FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.14065806
107* ATF3_27146783_Chip-Seq_COLON_Human1.13003026
108MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12676460
109RXR_22108803_ChIP-Seq_LS180_Human1.11930796
110FOXO3_23340844_ChIP-Seq_DLD1_Human1.11257251
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10665761
112RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10526142
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.08728310
114KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07753986
115TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07650549
116* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07103382
117HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06976059
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06592396
119PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05956145
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05920957
121SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04962588
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04944229
123RUNX2_22187159_ChIP-Seq_PCA_Human1.02795900
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02502541
125TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.01615774
126NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01183245
127GABP_19822575_ChIP-Seq_HepG2_Human1.00743947
128* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00696829
129TCF4_22108803_ChIP-Seq_LS180_Human0.99313363
130TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99009327
131FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.98967290
132ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98793565
133SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95332156
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94250995
135RXR_22158963_ChIP-Seq_LIVER_Mouse0.94056704
136STAT3_23295773_ChIP-Seq_U87_Human0.93976138
137MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93049777
138* SMAD3_21741376_ChIP-Seq_HESCs_Human0.92729717
139CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92707626
140SMAD3_21741376_ChIP-Seq_ESCs_Human0.91820269
141PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90853035
142* TP63_22573176_ChIP-Seq_HFKS_Human0.90844531
143UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90795713
144ESR2_21235772_ChIP-Seq_MCF-7_Human0.90639011
145NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90515907
146ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90225319
147YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89978603
148CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88361801
149KDM5A_27292631_Chip-Seq_BREAST_Human0.87742678
150CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86671114
151CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86382190
152* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.85926803
153TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85872979
154KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85083132
155TP53_20018659_ChIP-ChIP_R1E_Mouse0.85067805
156CLOCK_20551151_ChIP-Seq_293T_Human0.84749494
157IGF1R_20145208_ChIP-Seq_DFB_Human0.84651880
158* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84502033
159* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84139986
160FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.83480590
161E2F1_18555785_ChIP-Seq_MESCs_Mouse0.83463017
162* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82984461
163* TP63_23658742_ChIP-Seq_EP156T_Human0.82585588
164* CTCF_27219007_Chip-Seq_Bcells_Human0.82359547
165MYC_18555785_ChIP-Seq_MESCs_Mouse0.81794692
166CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.81721169
167FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.81305466
168P53_22127205_ChIP-Seq_FIBROBLAST_Human0.81192490
169POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80983965
170TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80983965
171* NANOG_18555785_Chip-Seq_ESCs_Mouse0.80882571
172EGR1_23403033_ChIP-Seq_LIVER_Mouse0.80134743
173ELK1_22589737_ChIP-Seq_MCF10A_Human0.79881269
174MYC_19030024_ChIP-ChIP_MESCs_Mouse0.79743959
175TP53_16413492_ChIP-PET_HCT116_Human0.79577059
176MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.78740608
177STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78196367
178NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.78044634
179SALL4_18804426_ChIP-ChIP_XEN_Mouse0.76511226
180FOXA1_25552417_ChIP-Seq_VCAP_Human0.76444703
181ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.76269901
182* FOXA2_19822575_ChIP-Seq_HepG2_Human0.74924338
183PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74915610
184TCF3_18692474_ChIP-Seq_MEFs_Mouse0.72669922
185PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.72666606
186GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.72099972

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier4.82590784
2MP0010234_abnormal_vibrissa_follicle4.58754088
3MP0004859_abnormal_synaptic_plasticity3.85282958
4MP0004264_abnormal_extraembryonic_tissu3.82893374
5MP0003880_abnormal_central_pattern3.33642815
6MP0003941_abnormal_skin_development3.03982578
7MP0003635_abnormal_synaptic_transmissio2.98094189
8MP0001968_abnormal_touch/_nociception2.89027385
9MP0009046_muscle_twitch2.80874100
10MP0002736_abnormal_nociception_after2.67642689
11MP0009745_abnormal_behavioral_response2.59850120
12MP0004270_analgesia2.59190360
13MP0005501_abnormal_skin_physiology2.58661742
14MP0010030_abnormal_orbit_morphology2.58211979
15MP0002064_seizures2.56672943
16MP0001501_abnormal_sleep_pattern2.52786633
17MP0003705_abnormal_hypodermis_morpholog2.38973360
18MP0002063_abnormal_learning/memory/cond2.35867203
19MP0002735_abnormal_chemical_nociception2.24006022
20MP0005451_abnormal_body_composition2.19445119
21MP0004858_abnormal_nervous_system2.17908027
22MP0005275_abnormal_skin_tensile2.15308464
23MP0000462_abnormal_digestive_system2.09996092
24MP0008004_abnormal_stomach_pH2.09373814
25MP0003950_abnormal_plasma_membrane2.07972740
26MP0002734_abnormal_mechanical_nocicepti2.06734624
27MP0003191_abnormal_cellular_cholesterol2.05076115
28MP0002572_abnormal_emotion/affect_behav2.04985679
29MP0010771_integument_phenotype2.02157714
30MP0010678_abnormal_skin_adnexa2.01487894
31MP0002272_abnormal_nervous_system2.01018012
32MP0003787_abnormal_imprinting1.99357914
33MP0000579_abnormal_nail_morphology1.97720707
34MP0000537_abnormal_urethra_morphology1.96650010
35MP0008875_abnormal_xenobiotic_pharmacok1.92621767
36MP0005083_abnormal_biliary_tract1.83162130
37MP0004381_abnormal_hair_follicle1.79124308
38MP0000516_abnormal_urinary_system1.76154790
39MP0005367_renal/urinary_system_phenotyp1.76154790
40MP0010352_gastrointestinal_tract_polyps1.75362034
41MP0001529_abnormal_vocalization1.69483343
42MP0001984_abnormal_olfaction1.69152472
43MP0000383_abnormal_hair_follicle1.68665602
44MP0001486_abnormal_startle_reflex1.68470122
45MP0003646_muscle_fatigue1.67541721
46MP0001216_abnormal_epidermal_layer1.67015715
47MP0008961_abnormal_basal_metabolism1.65015597
48MP0001986_abnormal_taste_sensitivity1.63913335
49MP0002098_abnormal_vibrissa_morphology1.61942639
50MP0005423_abnormal_somatic_nervous1.60370597
51MP0001970_abnormal_pain_threshold1.58950082
52MP0002733_abnormal_thermal_nociception1.58072657
53MP0005645_abnormal_hypothalamus_physiol1.55980667
54MP0002184_abnormal_innervation1.52759383
55MP0001440_abnormal_grooming_behavior1.52223236
56MP0002067_abnormal_sensory_capabilities1.50501624
57MP0003693_abnormal_embryo_hatching1.49230427
58MP0004272_abnormal_basement_membrane1.46022200
59MP0003329_amyloid_beta_deposits1.45089138
60MP0002282_abnormal_trachea_morphology1.43607708
61MP0003566_abnormal_cell_adhesion1.42142084
62MP0003879_abnormal_hair_cell1.40499003
63MP0009384_cardiac_valve_regurgitation1.36465025
64MP0003315_abnormal_perineum_morphology1.35825801
65MP0003938_abnormal_ear_development1.34755044
66MP0002557_abnormal_social/conspecific_i1.34150552
67MP0005023_abnormal_wound_healing1.34138335
68MP0002060_abnormal_skin_morphology1.33278483
69MP0008438_abnormal_cutaneous_collagen1.32364089
70MP0009379_abnormal_foot_pigmentation1.29700830
71MP0009780_abnormal_chondrocyte_physiolo1.29603974
72MP0000467_abnormal_esophagus_morphology1.28891484
73MP0003119_abnormal_digestive_system1.27813862
74MP0008569_lethality_at_weaning1.27810313
75MP0000427_abnormal_hair_cycle1.27611416
76MP0004947_skin_inflammation1.27052019
77MP0003183_abnormal_peptide_metabolism1.26996011
78MP0004811_abnormal_neuron_physiology1.26300107
79MP0005377_hearing/vestibular/ear_phenot1.25912104
80MP0003878_abnormal_ear_physiology1.25912104
81MP0001666_abnormal_nutrient_absorption1.22588866
82MP0005623_abnormal_meninges_morphology1.22196383
83MP0003806_abnormal_nucleotide_metabolis1.20120490
84MP0002254_reproductive_system_inflammat1.19695405
85MP0006276_abnormal_autonomic_nervous1.19145549
86MP0005646_abnormal_pituitary_gland1.17580065
87MP0003453_abnormal_keratinocyte_physiol1.16749931
88MP0005408_hypopigmentation1.15474356
89MP0002876_abnormal_thyroid_physiology1.13505994
90MP0000627_abnormal_mammary_gland1.12797580
91MP0003942_abnormal_urinary_system1.12636676
92MP0009053_abnormal_anal_canal1.12160997
93MP0001664_abnormal_digestion1.11492843
94MP0002233_abnormal_nose_morphology1.11463476
95MP0004484_altered_response_of1.09518019
96MP0000566_synostosis1.08556368
97MP0000681_abnormal_thyroid_gland1.08353107
98MP0003186_abnormal_redox_activity1.07312313
99MP0004957_abnormal_blastocyst_morpholog1.04770448
100MP0004142_abnormal_muscle_tone1.04127433
101MP0003937_abnormal_limbs/digits/tail_de1.01188960
102MP0005386_behavior/neurological_phenoty1.00904924
103MP0004924_abnormal_behavior1.00904924
104MP0001243_abnormal_dermal_layer0.99209238
105MP0003045_fibrosis0.97737784
106MP0002132_abnormal_respiratory_system0.97601054
107MP0000647_abnormal_sebaceous_gland0.97339846
108MP0002163_abnormal_gland_morphology0.97269720
109MP0002909_abnormal_adrenal_gland0.95461695
110MP0000377_abnormal_hair_follicle0.92144866
111MP0005503_abnormal_tendon_morphology0.91579367
112MP0000678_abnormal_parathyroid_gland0.90812025
113MP0008877_abnormal_DNA_methylation0.90790728
114MP0000955_abnormal_spinal_cord0.90353521
115MP0003718_maternal_effect0.89958521
116MP0001286_abnormal_eye_development0.89138879
117MP0005394_taste/olfaction_phenotype0.89108520
118MP0005499_abnormal_olfactory_system0.89108520
119MP0004133_heterotaxia0.87905036
120MP0008789_abnormal_olfactory_epithelium0.87868976
121MP0002160_abnormal_reproductive_system0.87803910
122MP0003890_abnormal_embryonic-extraembry0.87037977
123MP0000778_abnormal_nervous_system0.86424919
124MP0002108_abnormal_muscle_morphology0.85785865
125MP0002882_abnormal_neuron_morphology0.85765524
126MP0002837_dystrophic_cardiac_calcinosis0.85570942
127MP0003936_abnormal_reproductive_system0.85312907
128MP0004019_abnormal_vitamin_homeostasis0.84857403
129MP0005165_increased_susceptibility_to0.84480693
130MP0001697_abnormal_embryo_size0.84161015
131MP0001849_ear_inflammation0.83963822
132MP0002084_abnormal_developmental_patter0.82512627
133MP0001881_abnormal_mammary_gland0.81631943
134MP0003122_maternal_imprinting0.80183164
135MP0002066_abnormal_motor_capabilities/c0.79393357
136MP0000470_abnormal_stomach_morphology0.78308374
137MP0002822_catalepsy0.77532658
138MP0000762_abnormal_tongue_morphology0.76197154
139MP0003935_abnormal_craniofacial_develop0.74297213
140MP0002234_abnormal_pharynx_morphology0.73678840
141MP0001905_abnormal_dopamine_level0.71243728
142MP0000751_myopathy0.70956590
143MP0001958_emphysema0.69890837
144MP0009250_abnormal_appendicular_skeleto0.69270519
145MP0002009_preneoplasia0.68910177
146MP0001340_abnormal_eyelid_morphology0.68638986
147MP0004782_abnormal_surfactant_physiolog0.68587771
148MP0002069_abnormal_eating/drinking_beha0.67954486
149MP0001346_abnormal_lacrimal_gland0.67621146
150MP0004233_abnormal_muscle_weight0.67249758
151MP0000538_abnormal_urinary_bladder0.65956831
152MP0001672_abnormal_embryogenesis/_devel0.65758327
153MP0005380_embryogenesis_phenotype0.65758327
154MP0010386_abnormal_urinary_bladder0.65723881
155MP0001191_abnormal_skin_condition0.65604911
156MP0002085_abnormal_embryonic_tissue0.65436566
157MP0003984_embryonic_growth_retardation0.65397002
158MP0002111_abnormal_tail_morphology0.65163659
159MP0008874_decreased_physiological_sensi0.65075395
160MP0002088_abnormal_embryonic_growth/wei0.64621521
161MP0005395_other_phenotype0.64602615
162MP0000733_abnormal_muscle_development0.64523485
163MP0000639_abnormal_adrenal_gland0.64228016
164MP0003786_premature_aging0.64116433
165MP0000367_abnormal_coat/_hair0.63702127
166MP0009931_abnormal_skin_appearance0.62643665
167MP0004043_abnormal_pH_regulation0.59975266
168MP0003866_abnormal_defecation0.59000219
169MP0001348_abnormal_lacrimal_gland0.58885776
170MP0003763_abnormal_thymus_physiology0.57516428

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.35728474
2Focal motor seizures (HP:0011153)5.65115708
3Rhinitis (HP:0012384)5.35527547
4Abnormal respiratory motile cilium morphology (HP:0005938)5.30679751
5Abnormal respiratory epithelium morphology (HP:0012253)5.30679751
6Abnormal respiratory motile cilium physiology (HP:0012261)5.23736230
7Myokymia (HP:0002411)5.20433987
8Dynein arm defect of respiratory motile cilia (HP:0012255)5.15003466
9Absent/shortened dynein arms (HP:0200106)5.15003466
10Abnormal ciliary motility (HP:0012262)4.85152659
11Chronic bronchitis (HP:0004469)4.74044975
12Atonic seizures (HP:0010819)4.45987326
13Onycholysis (HP:0001806)4.42969744
14Fragile nails (HP:0001808)4.30400222
15Hypotrichosis (HP:0001006)4.07515216
16Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.04908312
17Pili torti (HP:0003777)4.00728710
18Congenital ichthyosiform erythroderma (HP:0007431)3.97406188
19Febrile seizures (HP:0002373)3.95049899
20Plantar hyperkeratosis (HP:0007556)3.80097484
21Focal seizures (HP:0007359)3.79590055
22Increased IgE level (HP:0003212)3.66491952
23Popliteal pterygium (HP:0009756)3.58013809
24Bronchiectasis (HP:0002110)3.54350111
25Absence seizures (HP:0002121)3.53594726
26Short nail (HP:0001799)3.43206270
27Woolly hair (HP:0002224)3.35370625
28Epileptic encephalopathy (HP:0200134)3.33652360
29Lip pit (HP:0100267)3.32583453
30Progressive cerebellar ataxia (HP:0002073)3.30536274
31Conjunctival hamartoma (HP:0100780)3.21639166
32Bell-shaped thorax (HP:0001591)3.21078194
33Right ventricular cardiomyopathy (HP:0011663)3.10602176
34Visual hallucinations (HP:0002367)3.01565034
35Abnormal hair whorl (HP:0010721)2.98877155
36Palmoplantar hyperkeratosis (HP:0000972)2.91777186
37Milia (HP:0001056)2.91481366
38Dry hair (HP:0011359)2.86361491
39Generalized tonic-clonic seizures (HP:0002069)2.85865037
40Amelogenesis imperfecta (HP:0000705)2.83417895
41Dialeptic seizures (HP:0011146)2.82731214
42Hypoplastic pelvis (HP:0008839)2.81999567
43Abnormal pancreas size (HP:0012094)2.74434058
44Erythroderma (HP:0001019)2.73624683
45Nasal polyposis (HP:0100582)2.70334471
46Ventricular fibrillation (HP:0001663)2.69625606
47Polyphagia (HP:0002591)2.68214883
48Palmar hyperkeratosis (HP:0010765)2.60869221
49Erythema (HP:0010783)2.55872590
50Abnormality of the umbilical cord (HP:0010881)2.53778993
51Acute necrotizing encephalopathy (HP:0006965)2.52264782
52Severe Myopia (HP:0011003)2.51764286
53Labial hypoplasia (HP:0000066)2.51400762
54Poor suck (HP:0002033)2.50519487
55Progressive macrocephaly (HP:0004481)2.48969419
56Aplasia/Hypoplasia of the sacrum (HP:0008517)2.48145739
57Spontaneous abortion (HP:0005268)2.46593505
58Progressive inability to walk (HP:0002505)2.46104374
59Impaired vibration sensation in the lower limbs (HP:0002166)2.45857572
60Curly hair (HP:0002212)2.45421355
61Abnormality of the distal phalanges of the toes (HP:0010182)2.45097164
62Abnormal mitochondria in muscle tissue (HP:0008316)2.44750761
63Abnormality of binocular vision (HP:0011514)2.44298799
64Diplopia (HP:0000651)2.44298799
65Sparse eyelashes (HP:0000653)2.43127135
66Mutism (HP:0002300)2.42353615
67Failure to thrive in infancy (HP:0001531)2.42283129
68Ankle clonus (HP:0011448)2.41687444
69Abnormal eating behavior (HP:0100738)2.40142363
70Parakeratosis (HP:0001036)2.39615304
71Abnormal umbilical cord blood vessels (HP:0011403)2.39239577
72Single umbilical artery (HP:0001195)2.39239577
73Abnormality of the fetal cardiovascular system (HP:0010948)2.39239577
74Nail dystrophy (HP:0008404)2.38569787
75Hyperthyroidism (HP:0000836)2.37535905
76Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.35315145
77Hypoplastic female external genitalia (HP:0012815)2.33053844
78Palpebral edema (HP:0100540)2.31607977
79Male infertility (HP:0003251)2.30048257
80Abnormality of nail color (HP:0100643)2.29809380
81Cervical subluxation (HP:0003308)2.28585421
82Corneal erosion (HP:0200020)2.26574690
83Concave nail (HP:0001598)2.26444145
84Hyperactive renin-angiotensin system (HP:0000841)2.25382429
85Abnormality of permanent molar morphology (HP:0011071)2.22939005
86Abnormality of the dental root (HP:0006486)2.22939005
87Taurodontia (HP:0000679)2.22939005
88Abnormality of the labia minora (HP:0012880)2.21377068
89Dysdiadochokinesis (HP:0002075)2.20139362
90Reduced subcutaneous adipose tissue (HP:0003758)2.18864916
91Enlarged kidneys (HP:0000105)2.16518015
92Goiter (HP:0000853)2.16405599
93Abnormal hair laboratory examination (HP:0003328)2.15293262
94Redundant skin (HP:0001582)2.13776182
95Abnormal blistering of the skin (HP:0008066)2.13764248
96Pheochromocytoma (HP:0002666)2.10658787
97Abnormality of molar (HP:0011077)2.09753127
98Abnormality of molar morphology (HP:0011070)2.09753127
99Posterior subcapsular cataract (HP:0007787)2.09053424
100Brittle hair (HP:0002299)2.08839032
101Truncal ataxia (HP:0002078)2.08382382
102Hypoplastic labia majora (HP:0000059)2.07634478
103Ankyloglossia (HP:0010296)2.06232937
104Aplasia of the musculature (HP:0100854)2.05042980
105Pancreatic fibrosis (HP:0100732)2.04009642
106Hypohidrosis (HP:0000966)2.02669510
107Abnormality of the nasal mucosa (HP:0000433)2.02578588
108Arterial tortuosity (HP:0005116)2.02009372
109Ulnar claw (HP:0001178)2.01345212
110Sparse scalp hair (HP:0002209)2.00494038
111Tubulointerstitial nephritis (HP:0001970)1.98863659
112Cystic liver disease (HP:0006706)1.98430675
113Myelomeningocele (HP:0002475)1.96685142
114Hamartoma of the eye (HP:0010568)1.96600415
115Abnormalities of placenta or umbilical cord (HP:0001194)1.96525708
116Generalized myoclonic seizures (HP:0002123)1.95089608
117Absent eyelashes (HP:0000561)1.94501250
118Broad-based gait (HP:0002136)1.94022201
119Sleep apnea (HP:0010535)1.93895152
120Aortic dissection (HP:0002647)1.92967662
121Infertility (HP:0000789)1.92955746
122Shoulder girdle muscle weakness (HP:0003547)1.91633918
123Occipital encephalocele (HP:0002085)1.90947514
124Abnormality of the dental pulp (HP:0006479)1.90172474
125Neuroendocrine neoplasm (HP:0100634)1.90090941
126Pterygium (HP:0001059)1.90059689
127Pancreatic cysts (HP:0001737)1.89686486
128Alopecia of scalp (HP:0002293)1.89629609
129Hip dysplasia (HP:0001385)1.88805118
130Abnormality of the frontal sinuses (HP:0002687)1.88186341
131Abnormality of dental color (HP:0011073)1.87981207
132Glucose intolerance (HP:0000833)1.87767893
133Bifid tongue (HP:0010297)1.87453072
134Absent frontal sinuses (HP:0002688)1.87326289
135Intrahepatic cholestasis (HP:0001406)1.87238106
136Abnormal delivery (HP:0001787)1.86931995
137Ventricular tachycardia (HP:0004756)1.86880009
138Neuronal loss in central nervous system (HP:0002529)1.86656850
139Supranuclear gaze palsy (HP:0000605)1.86324369
140Asthma (HP:0002099)1.85689545
141Renal salt wasting (HP:0000127)1.85595048
142Septate vagina (HP:0001153)1.85594518
143Action tremor (HP:0002345)1.85455954
144Abnormality of the labia majora (HP:0012881)1.85192144
145Fetal akinesia sequence (HP:0001989)1.83365915
146Sensory axonal neuropathy (HP:0003390)1.83309808
147Tubular atrophy (HP:0000092)1.82310558
148Abnormality of the renal cortex (HP:0011035)1.81893629
149Termporal pattern (HP:0011008)1.81811508
150Insidious onset (HP:0003587)1.81811508
151Anxiety (HP:0000739)1.81726303
152Aplasia/Hypoplasia of the tongue (HP:0010295)1.81628095
153Long toe (HP:0010511)1.78986672
154Abnormality of oral frenula (HP:0000190)1.78936739
155Bronchitis (HP:0012387)1.78804106
156Hypodontia (HP:0000668)1.78185991
157Specific learning disability (HP:0001328)1.78163724
158Vertebral arch anomaly (HP:0008438)1.76128565
159Inability to walk (HP:0002540)1.76107445
160Hypercortisolism (HP:0001578)1.75861351
161Esotropia (HP:0000565)1.75119206
162Genetic anticipation (HP:0003743)1.74994560
163Facial cleft (HP:0002006)1.74967930
164Beaking of vertebral bodies (HP:0004568)1.74015894
165Exotropia (HP:0000577)1.71697921
166Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.71084558
167Vascular tortuosity (HP:0004948)1.70513238
168Hoarse voice (HP:0001609)1.69541826
169Adrenal hypoplasia (HP:0000835)1.67343288
170Spastic tetraplegia (HP:0002510)1.67277469
171Intellectual disability, profound (HP:0002187)1.67129518
172Amblyopia (HP:0000646)1.66630227
173Limb dystonia (HP:0002451)1.65374197
174Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.64900377
175Renal dysplasia (HP:0000110)1.64854941
176Absent eyebrow (HP:0002223)1.64321967
177Mitochondrial inheritance (HP:0001427)1.63853310
178Resting tremor (HP:0002322)1.63754437
179Hypoparathyroidism (HP:0000829)1.61887035
180Abnormal auditory evoked potentials (HP:0006958)1.60998192
181Bicornuate uterus (HP:0000813)1.60817384
182Gout (HP:0001997)1.59523635
183Anhidrosis (HP:0000970)1.56705637
184Distal lower limb muscle weakness (HP:0009053)1.56558441
185Hypoplasia of the uterus (HP:0000013)1.56262544
186Abnormal tarsal ossification (HP:0008369)1.55667178
187Median cleft lip (HP:0000161)1.54422932
188Stridor (HP:0010307)1.53745608
189Subcapsular cataract (HP:0000523)1.52743293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.73827102
2MAP3K94.56862761
3MAP3K124.55252443
4PBK4.49164336
5MST43.69313748
6MAP2K73.62817526
7MUSK3.33583164
8MAP3K43.27576060
9PIK3CA2.92221149
10MARK12.48822058
11MAP2K42.45923950
12NTRK32.38519508
13MAPKAPK32.37043138
14CASK2.37011145
15MINK12.21225029
16CCNB12.12632106
17NTRK22.11790962
18EPHA42.04911265
19TRIM282.04854549
20PDK22.00198197
21LATS11.88929189
22DAPK21.84140774
23MAPK151.80346730
24STK161.79201376
25PAK41.76141507
26SCYL21.74115885
27PKN21.68557367
28STK241.66761554
29STK391.63376526
30NME21.63231316
31MET1.59729385
32PTK21.51433090
33GRK51.49926803
34DAPK11.49686712
35TRIB31.48086041
36FER1.44460374
37NME11.44372526
38PLK21.43924484
39KSR21.43008617
40MAP3K31.38739050
41LATS21.38398034
42TSSK61.35463160
43STK38L1.34179162
44MAP3K21.30351222
45FRK1.25905509
46CDK191.25708571
47ILK1.22326358
48EIF2AK31.20462083
49MAPK131.12044467
50RET1.10613032
51CDK51.10581323
52ERBB41.10514287
53TXK1.08811008
54BMPR1B1.06981635
55MAP3K131.04739319
56TGFBR11.04418623
57SMG11.04384518
58PRKCG1.03886915
59OXSR11.03745844
60KSR11.02168951
61SGK20.98109734
62LRRK20.97386238
63GRK70.95732016
64MELK0.93371558
65PAK60.91327438
66STK380.90205750
67VRK20.90028714
68PAK30.90020938
69UHMK10.87164342
70NTRK10.87002194
71SGK2230.84094264
72SGK4940.84094264
73NEK60.82407857
74ACVR1B0.80755557
75TAOK10.80262264
76CAMK2A0.78717721
77CHUK0.77170254
78MAPKAPK50.75954509
79BUB10.75355869
80FGFR20.75266383
81TTK0.75132787
82PRKCE0.72529224
83EIF2AK10.70524135
84PDK40.70358313
85PDK30.70358313
86DYRK1A0.69714235
87CDK30.69622026
88ITK0.65793222
89BRSK10.65642472
90CAMK2G0.65447151
91RPS6KA20.64898995
92MAP2K10.64633821
93ADRBK10.62642493
94CAMKK10.62358631
95ERBB30.61399344
96FLT30.61353657
97EEF2K0.60995023
98FGFR30.60970386
99SGK30.59382172
100BRSK20.58881818
101LIMK10.58068484
102ICK0.57286476
103SIK10.57166015
104MAP3K10.57163973
105MAP3K60.54249232
106MST1R0.53774584
107PRKCH0.53705752
108RIPK40.52642396
109SIK30.52141956
110TESK10.51763405
111AKT30.51024418
112RPS6KL10.50611456
113RPS6KC10.50611456
114CAMK10.50337968
115ABL20.49922062
116BRAF0.49068873
117CAMK40.48569680
118FES0.48528860
119STK110.47922745
120MARK20.47899039
121STK30.47858214
122BCR0.47773812
123CDK80.47703709
124AKT20.46998672
125NEK10.46564240
126CAMK2B0.46265490
127PRKD30.45657775
128TNK20.45332997
129MAP3K70.45221260
130CAMK2D0.44608262
131MAP2K20.44228316
132AURKB0.43507823
133CDK140.43102580
134LMTK20.42970078
135ARAF0.42461260
136EPHA30.42175063
137PLK10.41980831
138FGFR10.40525992
139MAP2K60.39324071
140RPS6KB20.38746690
141MYLK0.38258784
142BCKDK0.38249358
143PLK40.38109415
144FYN0.37815237
145CSNK1A1L0.37698338
146SGK10.37297601
147PRKCD0.36931818
148CDK180.36813137
149PHKG20.36694072
150PHKG10.36694072
151TNIK0.36621728
152PRKCI0.35995840
153AURKA0.35298624
154STK100.34055493
155PASK0.33326674
156DAPK30.32122826
157ROCK10.30323315
158SRPK10.28340356
159CHEK20.27693163
160PAK10.27324208
161CSNK1G30.25280692
162PTK60.24980362
163CDK70.24234266

Predicted pathways (KEGG)

RankGene SetZ-score
1Collecting duct acid secretion_Homo sapiens_hsa049663.67910530
2Synaptic vesicle cycle_Homo sapiens_hsa047213.63529968
3Proteasome_Homo sapiens_hsa030503.50783059
4Nicotine addiction_Homo sapiens_hsa050333.09680738
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.02270942
6Glutathione metabolism_Homo sapiens_hsa004802.94512737
7Olfactory transduction_Homo sapiens_hsa047402.34978113
8Chemical carcinogenesis_Homo sapiens_hsa052042.26827261
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.19612366
10Long-term potentiation_Homo sapiens_hsa047202.14428674
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.14333881
12GABAergic synapse_Homo sapiens_hsa047272.07032433
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.03527048
14Gastric acid secretion_Homo sapiens_hsa049712.00660415
15Vibrio cholerae infection_Homo sapiens_hsa051101.98839088
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.95907698
17Circadian entrainment_Homo sapiens_hsa047131.95708831
18Oxidative phosphorylation_Homo sapiens_hsa001901.95105520
19Salivary secretion_Homo sapiens_hsa049701.92216719
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87896949
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.81695479
22Dopaminergic synapse_Homo sapiens_hsa047281.81113763
23Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.79975012
24Morphine addiction_Homo sapiens_hsa050321.75668058
25Amphetamine addiction_Homo sapiens_hsa050311.74814333
26Taste transduction_Homo sapiens_hsa047421.72192572
27Protein export_Homo sapiens_hsa030601.71741786
28Glutamatergic synapse_Homo sapiens_hsa047241.70499266
29Tyrosine metabolism_Homo sapiens_hsa003501.70028584
30Nucleotide excision repair_Homo sapiens_hsa034201.60238737
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56509862
32Long-term depression_Homo sapiens_hsa047301.56171118
33Histidine metabolism_Homo sapiens_hsa003401.55800430
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.54837117
35Renin secretion_Homo sapiens_hsa049241.48627440
36N-Glycan biosynthesis_Homo sapiens_hsa005101.45082260
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42864878
38Serotonergic synapse_Homo sapiens_hsa047261.39079804
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.37874620
40Adherens junction_Homo sapiens_hsa045201.35625258
41Vitamin digestion and absorption_Homo sapiens_hsa049771.34480656
42Cholinergic synapse_Homo sapiens_hsa047251.32067309
43Steroid biosynthesis_Homo sapiens_hsa001001.30160280
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29566163
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27245646
46Oxytocin signaling pathway_Homo sapiens_hsa049211.26994834
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26286612
48Pentose and glucuronate interconversions_Homo sapiens_hsa000401.25621298
49Insulin secretion_Homo sapiens_hsa049111.25162543
50Retinol metabolism_Homo sapiens_hsa008301.23760256
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23635511
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23439912
53Alzheimers disease_Homo sapiens_hsa050101.23306552
54Calcium signaling pathway_Homo sapiens_hsa040201.22269399
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21348188
56GnRH signaling pathway_Homo sapiens_hsa049121.20402010
57Rheumatoid arthritis_Homo sapiens_hsa053231.20378232
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18375427
59Peroxisome_Homo sapiens_hsa041461.18317788
60Parkinsons disease_Homo sapiens_hsa050121.16557660
61beta-Alanine metabolism_Homo sapiens_hsa004101.16302397
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13516562
63Pyruvate metabolism_Homo sapiens_hsa006201.12020044
64Melanogenesis_Homo sapiens_hsa049161.08386677
65Axon guidance_Homo sapiens_hsa043601.06654552
66Phototransduction_Homo sapiens_hsa047441.06525150
67Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06339459
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06323512
69Pentose phosphate pathway_Homo sapiens_hsa000301.05845984
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05583402
71p53 signaling pathway_Homo sapiens_hsa041151.05420414
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04210876
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03781641
74Ribosome_Homo sapiens_hsa030101.03197258
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02366171
76Gap junction_Homo sapiens_hsa045401.00508845
77Cocaine addiction_Homo sapiens_hsa050301.00364251
78Basal cell carcinoma_Homo sapiens_hsa052170.99147303
79ECM-receptor interaction_Homo sapiens_hsa045120.96043306
80Other glycan degradation_Homo sapiens_hsa005110.95337838
81Fat digestion and absorption_Homo sapiens_hsa049750.94791880
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92513189
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92300819
84RNA polymerase_Homo sapiens_hsa030200.91586971
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91211890
86Estrogen signaling pathway_Homo sapiens_hsa049150.90393225
87Cardiac muscle contraction_Homo sapiens_hsa042600.88914608
88ErbB signaling pathway_Homo sapiens_hsa040120.88838277
89Sphingolipid metabolism_Homo sapiens_hsa006000.87735383
90Mismatch repair_Homo sapiens_hsa034300.87535463
91Galactose metabolism_Homo sapiens_hsa000520.87073144
92Arachidonic acid metabolism_Homo sapiens_hsa005900.86391215
93Phagosome_Homo sapiens_hsa041450.85602115
94Pyrimidine metabolism_Homo sapiens_hsa002400.85587851
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85585409
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84201279
97cAMP signaling pathway_Homo sapiens_hsa040240.82388643
98Folate biosynthesis_Homo sapiens_hsa007900.81133961
99Thyroid hormone synthesis_Homo sapiens_hsa049180.80854115
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.79805480
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.79543109
102Propanoate metabolism_Homo sapiens_hsa006400.79422327
103Fanconi anemia pathway_Homo sapiens_hsa034600.78475590
104T cell receptor signaling pathway_Homo sapiens_hsa046600.77835926
105Pancreatic secretion_Homo sapiens_hsa049720.77086493
106Colorectal cancer_Homo sapiens_hsa052100.77036111
107TGF-beta signaling pathway_Homo sapiens_hsa043500.76959062
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76725247
109Fatty acid degradation_Homo sapiens_hsa000710.76021733
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75989179
111Linoleic acid metabolism_Homo sapiens_hsa005910.75938097
112Glioma_Homo sapiens_hsa052140.75886545
113Endometrial cancer_Homo sapiens_hsa052130.74653502
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.74648714
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.72639503
116Metabolic pathways_Homo sapiens_hsa011000.70463712
117Hepatitis C_Homo sapiens_hsa051600.70253718
118Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69800737
119Proteoglycans in cancer_Homo sapiens_hsa052050.69577770
120Ras signaling pathway_Homo sapiens_hsa040140.69347544
121Hedgehog signaling pathway_Homo sapiens_hsa043400.69322008
122Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68603857
123Small cell lung cancer_Homo sapiens_hsa052220.67697429
124Wnt signaling pathway_Homo sapiens_hsa043100.67696965
125RNA transport_Homo sapiens_hsa030130.65638895
126Oocyte meiosis_Homo sapiens_hsa041140.65208593
127Dorso-ventral axis formation_Homo sapiens_hsa043200.63727908
128Carbon metabolism_Homo sapiens_hsa012000.63550843
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63417557
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61954026
131Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61749915
132VEGF signaling pathway_Homo sapiens_hsa043700.60803601
133Huntingtons disease_Homo sapiens_hsa050160.60054163
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60009755
135MAPK signaling pathway_Homo sapiens_hsa040100.59990322
136Sulfur metabolism_Homo sapiens_hsa009200.59936107
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.59867831
138Cysteine and methionine metabolism_Homo sapiens_hsa002700.59719659
139SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58545333
140Tight junction_Homo sapiens_hsa045300.57548240
141Rap1 signaling pathway_Homo sapiens_hsa040150.57384522
142Neurotrophin signaling pathway_Homo sapiens_hsa047220.56606005
143Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55401098
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.55043685
145Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54519034
146Homologous recombination_Homo sapiens_hsa034400.54254257
147Phenylalanine metabolism_Homo sapiens_hsa003600.52947400
148Type I diabetes mellitus_Homo sapiens_hsa049400.52131176
149Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51913035
150Type II diabetes mellitus_Homo sapiens_hsa049300.51888784
151Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51862101
152Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51790945
153Arginine and proline metabolism_Homo sapiens_hsa003300.51344617
154One carbon pool by folate_Homo sapiens_hsa006700.51185628
155Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51038177
156Melanoma_Homo sapiens_hsa052180.50657289
157Cyanoamino acid metabolism_Homo sapiens_hsa004600.49824945
158Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48167727
159Fatty acid elongation_Homo sapiens_hsa000620.47837668
160Inositol phosphate metabolism_Homo sapiens_hsa005620.47107604
161Focal adhesion_Homo sapiens_hsa045100.46362051
162Endocytosis_Homo sapiens_hsa041440.44802735
163Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43842355
164Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43147339
165Caffeine metabolism_Homo sapiens_hsa002320.42601449
166Thyroid cancer_Homo sapiens_hsa052160.42446382
167Hippo signaling pathway_Homo sapiens_hsa043900.41883619
168Base excision repair_Homo sapiens_hsa034100.39865167
169Glucagon signaling pathway_Homo sapiens_hsa049220.39571631
170Biosynthesis of amino acids_Homo sapiens_hsa012300.39089789
171Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36844363
172Choline metabolism in cancer_Homo sapiens_hsa052310.36645130
173Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36489528
174Starch and sucrose metabolism_Homo sapiens_hsa005000.36355693
175Renal cell carcinoma_Homo sapiens_hsa052110.35855177
176Ether lipid metabolism_Homo sapiens_hsa005650.35125711
177Protein digestion and absorption_Homo sapiens_hsa049740.34513256
178Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34511365
179Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34480553
180Pancreatic cancer_Homo sapiens_hsa052120.30536483
181Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30073701

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