LYPLA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.04495715
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.04495715
3L-phenylalanine metabolic process (GO:0006558)5.86790077
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.86790077
5aromatic amino acid family catabolic process (GO:0009074)5.78262014
6indole-containing compound catabolic process (GO:0042436)5.54574104
7indolalkylamine catabolic process (GO:0046218)5.54574104
8tryptophan catabolic process (GO:0006569)5.54574104
9lysine catabolic process (GO:0006554)5.46721276
10lysine metabolic process (GO:0006553)5.46721276
11tryptophan metabolic process (GO:0006568)5.32825049
12glyoxylate metabolic process (GO:0046487)5.31090378
13cysteine metabolic process (GO:0006534)5.27420186
14kynurenine metabolic process (GO:0070189)5.12281100
15serine family amino acid catabolic process (GO:0009071)4.92908875
16establishment of integrated proviral latency (GO:0075713)4.89457450
17homocysteine metabolic process (GO:0050667)4.81535878
18bile acid biosynthetic process (GO:0006699)4.67205306
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.66326728
20nuclear pore complex assembly (GO:0051292)4.64477024
21CENP-A containing nucleosome assembly (GO:0034080)4.60774008
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.59835097
23amino-acid betaine metabolic process (GO:0006577)4.59195585
24chromatin remodeling at centromere (GO:0031055)4.54696768
25urea cycle (GO:0000050)4.53175703
26urea metabolic process (GO:0019627)4.53175703
27urate metabolic process (GO:0046415)4.51006328
28sulfur amino acid catabolic process (GO:0000098)4.49685604
29glycine metabolic process (GO:0006544)4.45836267
30DNA strand elongation involved in DNA replication (GO:0006271)4.44432813
31serine family amino acid metabolic process (GO:0009069)4.38162863
32purine nucleobase biosynthetic process (GO:0009113)4.34533587
33nuclear pore organization (GO:0006999)4.33738279
34IMP biosynthetic process (GO:0006188)4.32153541
35aromatic amino acid family metabolic process (GO:0009072)4.30289898
36ribosome assembly (GO:0042255)4.27686576
37serine family amino acid biosynthetic process (GO:0009070)4.27345175
38DNA strand elongation (GO:0022616)4.26623135
39alpha-linolenic acid metabolic process (GO:0036109)4.19260656
40proteasome assembly (GO:0043248)4.17273051
41nitrogen cycle metabolic process (GO:0071941)4.16294779
42drug transmembrane transport (GO:0006855)4.15986208
43alpha-amino acid catabolic process (GO:1901606)4.15171206
44telomere maintenance via semi-conservative replication (GO:0032201)4.14618274
45drug catabolic process (GO:0042737)4.11148111
46bile acid metabolic process (GO:0008206)4.01525566
47high-density lipoprotein particle remodeling (GO:0034375)3.99356598
48formation of translation preinitiation complex (GO:0001731)3.98418839
49IMP metabolic process (GO:0046040)3.98241875
50indolalkylamine metabolic process (GO:0006586)3.96655607
512-oxoglutarate metabolic process (GO:0006103)3.86430839
52protein localization to kinetochore (GO:0034501)3.86149828
53nucleobase biosynthetic process (GO:0046112)3.85402731
54cellular amino acid catabolic process (GO:0009063)3.85367192
55mitotic metaphase plate congression (GO:0007080)3.84323794
56negative regulation of fibrinolysis (GO:0051918)3.83450005
57histone exchange (GO:0043486)3.82646135
58regulation of triglyceride catabolic process (GO:0010896)3.81021256
59cellular biogenic amine catabolic process (GO:0042402)3.80987640
60amine catabolic process (GO:0009310)3.80987640
61regulation of protein activation cascade (GO:2000257)3.80700899
62protein carboxylation (GO:0018214)3.79576807
63peptidyl-glutamic acid carboxylation (GO:0017187)3.79576807
64complement activation, alternative pathway (GO:0006957)3.78072256
65valine metabolic process (GO:0006573)3.77170053
66DNA replication-independent nucleosome organization (GO:0034724)3.74519250
67DNA replication-independent nucleosome assembly (GO:0006336)3.74519250
68DNA replication checkpoint (GO:0000076)3.74026039
69tyrosine metabolic process (GO:0006570)3.73566886
70cellular ketone body metabolic process (GO:0046950)3.72240161
71establishment of viral latency (GO:0019043)3.71861929
72drug transport (GO:0015893)3.70217272
73negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.67751970
74regulation of fibrinolysis (GO:0051917)3.67054736
75carnitine metabolic process (GO:0009437)3.65401842
76aspartate family amino acid catabolic process (GO:0009068)3.64450920
77cellular glucuronidation (GO:0052695)3.63965740
78fatty acid beta-oxidation (GO:0006635)3.63120272
79telomere maintenance via recombination (GO:0000722)3.62248590
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.61432707
81benzene-containing compound metabolic process (GO:0042537)3.60034266
82aldehyde catabolic process (GO:0046185)3.58924407
83regulation of cholesterol esterification (GO:0010872)3.58754629
84triglyceride homeostasis (GO:0070328)3.58483770
85acylglycerol homeostasis (GO:0055090)3.58483770
86folic acid-containing compound biosynthetic process (GO:0009396)3.57940702
87mitotic recombination (GO:0006312)3.57447097
88regulation of complement activation (GO:0030449)3.57020855
89mitotic sister chromatid cohesion (GO:0007064)3.55883217
90bile acid and bile salt transport (GO:0015721)3.55862170
91exogenous drug catabolic process (GO:0042738)3.54285327
92branched-chain amino acid catabolic process (GO:0009083)3.54087046
93double-strand break repair via nonhomologous end joining (GO:0006303)3.53661359
94non-recombinational repair (GO:0000726)3.53661359
95fatty acid oxidation (GO:0019395)3.53615460
96imidazole-containing compound metabolic process (GO:0052803)3.52334099
97DNA unwinding involved in DNA replication (GO:0006268)3.51906946
98negative regulation of sterol transport (GO:0032372)3.51754364
99negative regulation of cholesterol transport (GO:0032375)3.51754364
100carboxylic acid catabolic process (GO:0046395)3.48902161
101organic acid catabolic process (GO:0016054)3.48902161
102protein localization to chromosome, centromeric region (GO:0071459)3.47497346
103negative regulation of mitotic sister chromatid separation (GO:2000816)3.47352456
104negative regulation of sister chromatid segregation (GO:0033046)3.47352456
105negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.47352456
106negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.47352456
107negative regulation of mitotic sister chromatid segregation (GO:0033048)3.47352456
108mitotic spindle checkpoint (GO:0071174)3.46369222
109plasma lipoprotein particle remodeling (GO:0034369)3.45977988
110protein-lipid complex remodeling (GO:0034368)3.45977988
111macromolecular complex remodeling (GO:0034367)3.45977988
112lipid oxidation (GO:0034440)3.45844461
113branched-chain amino acid metabolic process (GO:0009081)3.45472286
114reverse cholesterol transport (GO:0043691)3.44361909
115negative regulation of chromosome segregation (GO:0051985)3.44169958
116anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.43446861
117cellular modified amino acid catabolic process (GO:0042219)3.41579479
118spindle checkpoint (GO:0031577)3.41352604
119ethanol oxidation (GO:0006069)3.40355693
120phospholipid efflux (GO:0033700)3.38650356
121short-chain fatty acid metabolic process (GO:0046459)3.38181182
122pore complex assembly (GO:0046931)3.37896248
123mitotic sister chromatid segregation (GO:0000070)3.37767725
124L-serine metabolic process (GO:0006563)3.36810606
125metaphase plate congression (GO:0051310)3.36154136
126DNA ligation (GO:0006266)3.35060001
127somatic hypermutation of immunoglobulin genes (GO:0016446)3.34983593
128somatic diversification of immune receptors via somatic mutation (GO:0002566)3.34983593
129nicotinamide nucleotide biosynthetic process (GO:0019359)3.34733287
130pyridine nucleotide biosynthetic process (GO:0019363)3.34733287
131positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.34409632
132negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.32238180
133negative regulation of ligase activity (GO:0051352)3.32238180
134acetyl-CoA metabolic process (GO:0006084)3.31319110
135DNA double-strand break processing (GO:0000729)3.30770851
136mitotic spindle assembly checkpoint (GO:0007094)3.29653736
137glutamate metabolic process (GO:0006536)3.28970274
138regulation of helicase activity (GO:0051095)3.27073953
139tRNA aminoacylation for protein translation (GO:0006418)3.27059334
140glucuronate metabolic process (GO:0019585)3.26798928
141uronic acid metabolic process (GO:0006063)3.26798928
142fatty acid catabolic process (GO:0009062)3.26646188
143DNA replication initiation (GO:0006270)3.25160059
144spindle assembly checkpoint (GO:0071173)3.24910280
145drug metabolic process (GO:0017144)3.23749438
146monocarboxylic acid catabolic process (GO:0072329)3.23000416
147sister chromatid segregation (GO:0000819)3.22877869
148regulation of mitotic metaphase/anaphase transition (GO:0030071)3.22700411
149regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.22700411
150tRNA aminoacylation (GO:0043039)3.21287849
151amino acid activation (GO:0043038)3.21287849
152NAD biosynthetic process (GO:0009435)3.21033465
153synapsis (GO:0007129)3.19860221
154folic acid metabolic process (GO:0046655)3.18776228
155regulation of centriole replication (GO:0046599)3.18268312
156regulation of chromosome segregation (GO:0051983)3.18170761
157ketone body metabolic process (GO:1902224)3.18087058
158mitotic nuclear envelope disassembly (GO:0007077)3.17853261
159coenzyme catabolic process (GO:0009109)3.16968498
160arginine metabolic process (GO:0006525)3.16137237
161flavonoid metabolic process (GO:0009812)3.15869062
162regulation of bile acid biosynthetic process (GO:0070857)3.14625494
163positive regulation of triglyceride lipase activity (GO:0061365)3.14070069
164positive regulation of lipoprotein lipase activity (GO:0051006)3.14070069
165negative regulation of fatty acid biosynthetic process (GO:0045717)3.12108634
166sulfur amino acid metabolic process (GO:0000096)3.11591934
167regulation of sister chromatid segregation (GO:0033045)3.11294454
168regulation of mitotic sister chromatid separation (GO:0010965)3.11294454
169regulation of mitotic sister chromatid segregation (GO:0033047)3.11294454
170DNA catabolic process, exonucleolytic (GO:0000738)3.10401010
171telomere maintenance via telomere lengthening (GO:0010833)3.10303539
172regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.10161933
173regulation of mitotic spindle checkpoint (GO:1903504)3.10161933
174nucleotide-excision repair, DNA gap filling (GO:0006297)3.06556663
175DNA replication-dependent nucleosome assembly (GO:0006335)3.06136218
176DNA replication-dependent nucleosome organization (GO:0034723)3.06136218
177regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.02375799
178mitochondrial RNA metabolic process (GO:0000959)3.02282665
179transcription from mitochondrial promoter (GO:0006390)2.98242350
180cell cycle G1/S phase transition (GO:0044843)2.98037657
181G1/S transition of mitotic cell cycle (GO:0000082)2.98037657
182rRNA modification (GO:0000154)2.97182564
183mitotic G2/M transition checkpoint (GO:0044818)2.96091183
184mitotic chromosome condensation (GO:0007076)2.95691419
185somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.95121283
186isotype switching (GO:0045190)2.95121283
187somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.95121283
188ribosomal large subunit biogenesis (GO:0042273)2.92979424
189cullin deneddylation (GO:0010388)2.91210001
190positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.91120024
191membrane disassembly (GO:0030397)2.88913589
192nuclear envelope disassembly (GO:0051081)2.88913589
193ribosome biogenesis (GO:0042254)2.87793541
194kinetochore organization (GO:0051383)2.85071217
195response to X-ray (GO:0010165)2.85038186
196histone mRNA metabolic process (GO:0008334)2.84820636
197ATP-dependent chromatin remodeling (GO:0043044)2.83111946
198establishment of chromosome localization (GO:0051303)2.82923251
199protein complex localization (GO:0031503)2.82375716
200regulation of ubiquitin-protein transferase activity (GO:0051438)2.82116145

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.93632422
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.57158571
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.18087253
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.04073016
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.13035848
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.09831378
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.87282142
8E2F7_22180533_ChIP-Seq_HELA_Human3.79538645
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.55517266
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.02807023
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.47847781
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.34047961
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.21997778
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.20272116
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.18753085
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15151223
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08793725
18AR_21909140_ChIP-Seq_LNCAP_Human2.00392620
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98881866
20MYC_18555785_ChIP-Seq_MESCs_Mouse1.89325195
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86679760
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.85969341
23YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78376258
24TTF2_22483619_ChIP-Seq_HELA_Human1.77695422
25GATA1_22025678_ChIP-Seq_K562_Human1.74679440
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.73181867
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72500575
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.72242808
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68943116
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62284496
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59771597
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55759442
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.51044556
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48072814
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.45220249
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.44840855
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42694468
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40526746
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.39789073
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.38830133
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37365041
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35957772
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35104294
44TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.31780179
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31396509
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30191780
47KAP1_22055183_ChIP-Seq_ESCs_Mouse1.28438747
48MYC_18940864_ChIP-ChIP_HL60_Human1.27485644
49NANOG_16153702_ChIP-ChIP_HESCs_Human1.24196742
50ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22629686
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.21274249
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20121311
53E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18972870
54* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18825103
55CLOCK_20551151_ChIP-Seq_293T_Human1.15032437
56DCP1A_22483619_ChIP-Seq_HELA_Human1.14426617
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12735061
58SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12469892
59VDR_23849224_ChIP-Seq_CD4+_Human1.11616163
60ETS1_20019798_ChIP-Seq_JURKAT_Human1.11119345
61EWS_26573619_Chip-Seq_HEK293_Human1.10469088
62FOXP3_21729870_ChIP-Seq_TREG_Human1.10245032
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10232352
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10230253
65SOX17_20123909_ChIP-Seq_XEN_Mouse1.09633792
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08876715
67* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07763099
68CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05369877
69HNF4A_19822575_ChIP-Seq_HepG2_Human1.02373547
70TFEB_21752829_ChIP-Seq_HELA_Human1.01934823
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01360490
72SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01202564
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00843814
74* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00138451
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97295529
76SOX2_16153702_ChIP-ChIP_HESCs_Human0.96703153
77GATA4_25053715_ChIP-Seq_YYC3_Human0.95740195
78FUS_26573619_Chip-Seq_HEK293_Human0.95082016
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93895146
80E2F1_21310950_ChIP-Seq_MCF-7_Human0.93888059
81* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92897660
82RXRA_24833708_ChIP-Seq_LIVER_Mouse0.92121222
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91785675
84YY1_21170310_ChIP-Seq_MESCs_Mouse0.91737661
85* FLI1_27457419_Chip-Seq_LIVER_Mouse0.91274825
86* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90340726
87GABP_19822575_ChIP-Seq_HepG2_Human0.89345486
88NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.89125560
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89123346
90SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88710092
91PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87054840
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84674732
93POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84547874
94MYC_19079543_ChIP-ChIP_MESCs_Mouse0.84533268
95* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83789656
96HTT_18923047_ChIP-ChIP_STHdh_Human0.83680673
97* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83338551
98ZNF263_19887448_ChIP-Seq_K562_Human0.82855012
99ELF5_23300383_ChIP-Seq_T47D_Human0.80615943
100NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79756782
101IGF1R_20145208_ChIP-Seq_DFB_Human0.79424714
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.79387270
103POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.79258733
104NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.77989277
105CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77622281
106ELK1_19687146_ChIP-ChIP_HELA_Human0.77575409
107ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77350574
108TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77018875
109POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76466959
110CHD1_26751641_Chip-Seq_LNCaP_Human0.75491798
111IRF1_19129219_ChIP-ChIP_H3396_Human0.75450367
112HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.75413919
113XRN2_22483619_ChIP-Seq_HELA_Human0.74346289
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.74301368
115EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.73849496
116NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.72817509
117TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.72772064
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.72589181
119SOX2_27498859_Chip-Seq_STOMACH_Mouse0.72339522
120MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.70784005
121* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70716256
122IRF8_21731497_ChIP-ChIP_J774_Mouse0.70714903
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.69894835
124RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.68870360
125KDM5A_27292631_Chip-Seq_BREAST_Human0.68550799
126SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.68404921
127NOTCH1_21737748_ChIP-Seq_TLL_Human0.67676665
128MYB_21317192_ChIP-Seq_ERMYB_Mouse0.67381877
129KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.67286612
130AR_20517297_ChIP-Seq_VCAP_Human0.67259739
131STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.67147406
132* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.66322669
133FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.65944081
134RARA_24833708_ChIP-Seq_LIVER_Mouse0.65708532
135RBPJ_22232070_ChIP-Seq_NCS_Mouse0.64872585
136GATA2_22383799_ChIP-Seq_G1ME_Mouse0.64385051
137* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.64250268
138* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.63049472
139FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.62829486
140ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.62639630
141SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.62135297

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.14542133
2MP0002139_abnormal_hepatobiliary_system6.93484813
3MP0005085_abnormal_gallbladder_physiolo5.18616188
4MP0005365_abnormal_bile_salt5.11936055
5MP0003806_abnormal_nucleotide_metabolis4.23407976
6MP0008875_abnormal_xenobiotic_pharmacok4.17405576
7MP0003252_abnormal_bile_duct3.28250301
8MP0003941_abnormal_skin_development3.22317832
9MP0008932_abnormal_embryonic_tissue2.97246728
10MP0005332_abnormal_amino_acid2.91038450
11MP0008007_abnormal_cellular_replicative2.85101390
12MP0010329_abnormal_lipoprotein_level2.72482526
13MP0003195_calcinosis2.53531216
14MP0009840_abnormal_foam_cell2.53022349
15MP0004019_abnormal_vitamin_homeostasis2.44411166
16MP0008877_abnormal_DNA_methylation2.42508225
17MP0001666_abnormal_nutrient_absorption2.40292126
18MP0001730_embryonic_growth_arrest2.26871797
19MP0002138_abnormal_hepatobiliary_system2.25446723
20MP0003890_abnormal_embryonic-extraembry2.15072791
21MP0003191_abnormal_cellular_cholesterol2.02127190
22MP0001764_abnormal_homeostasis1.97506370
23MP0003186_abnormal_redox_activity1.96795704
24MP0005083_abnormal_biliary_tract1.96014781
25MP0000609_abnormal_liver_physiology1.91409906
26MP0005319_abnormal_enzyme/_coenzyme1.82699392
27MP0003786_premature_aging1.79418972
28MP0000350_abnormal_cell_proliferation1.78892046
29MP0009643_abnormal_urine_homeostasis1.76041251
30MP0001697_abnormal_embryo_size1.72569334
31MP0003567_abnormal_fetal_cardiomyocyte1.71415517
32MP0005380_embryogenesis_phenotype1.69448751
33MP0001672_abnormal_embryogenesis/_devel1.69448751
34MP0009697_abnormal_copulation1.66006553
35MP0002118_abnormal_lipid_homeostasis1.56378390
36MP0001293_anophthalmia1.52682580
37MP0003984_embryonic_growth_retardation1.51333340
38MP0005501_abnormal_skin_physiology1.48488270
39MP0002080_prenatal_lethality1.48331133
40MP0005451_abnormal_body_composition1.47775530
41MP0002088_abnormal_embryonic_growth/wei1.46289478
42MP0002084_abnormal_developmental_patter1.41182907
43MP0006036_abnormal_mitochondrial_physio1.38011552
44MP0000358_abnormal_cell_content/1.33954344
45MP0002009_preneoplasia1.30492812
46MP0000313_abnormal_cell_death1.30225607
47MP0005584_abnormal_enzyme/coenzyme_acti1.29491707
48MP0002086_abnormal_extraembryonic_tissu1.27570594
49MP0002085_abnormal_embryonic_tissue1.27561534
50MP0005636_abnormal_mineral_homeostasis1.24781932
51MP0004197_abnormal_fetal_growth/weight/1.19487320
52MP0002877_abnormal_melanocyte_morpholog1.19217088
53MP0000598_abnormal_liver_morphology1.18081130
54MP0005084_abnormal_gallbladder_morpholo1.17586486
55MP0003868_abnormal_feces_composition1.16421264
56MP0001929_abnormal_gametogenesis1.13473779
57MP0000372_irregular_coat_pigmentation1.13379912
58MP0002210_abnormal_sex_determination1.11828777
59MP0009764_decreased_sensitivity_to1.11784754
60MP0003718_maternal_effect1.10330395
61MP0004264_abnormal_extraembryonic_tissu1.09043974
62MP0003937_abnormal_limbs/digits/tail_de1.07400275
63MP0003693_abnormal_embryo_hatching1.06756758
64MP0000490_abnormal_crypts_of1.06366771
65MP0008469_abnormal_protein_level1.05033516
66MP0005408_hypopigmentation1.03599731
67MP0001145_abnormal_male_reproductive1.03097152
68MP0004043_abnormal_pH_regulation1.01506641
69MP0001756_abnormal_urination1.00482494
70MP0006292_abnormal_olfactory_placode1.00045414
71MP0009763_increased_sensitivity_to0.99664683
72MP0010678_abnormal_skin_adnexa0.98383671
73MP0000647_abnormal_sebaceous_gland0.97174282
74MP0003724_increased_susceptibility_to0.95997540
75MP0003315_abnormal_perineum_morphology0.95722170
76MP0000653_abnormal_sex_gland0.95495701
77MP0002136_abnormal_kidney_physiology0.94387623
78MP0005670_abnormal_white_adipose0.93696504
79MP0009703_decreased_birth_body0.92441858
80MP0000579_abnormal_nail_morphology0.92399693
81MP0002876_abnormal_thyroid_physiology0.92051382
82MP0003656_abnormal_erythrocyte_physiolo0.89852115
83MP0005266_abnormal_metabolism0.87243346
84MP0005647_abnormal_sex_gland0.86661712
85MP0005075_abnormal_melanosome_morpholog0.85893086
86MP0003705_abnormal_hypodermis_morpholog0.85519375
87MP0001661_extended_life_span0.84541398
88MP0001286_abnormal_eye_development0.84267143
89MP0006035_abnormal_mitochondrial_morpho0.83048746
90MP0005376_homeostasis/metabolism_phenot0.81673233
91MP0002697_abnormal_eye_size0.81461156
92MP0004957_abnormal_blastocyst_morpholog0.81254933
93MP0009053_abnormal_anal_canal0.80974102
94MP0002111_abnormal_tail_morphology0.80962660
95MP0001881_abnormal_mammary_gland0.80820371
96MP0005220_abnormal_exocrine_pancreas0.80787002
97MP0009642_abnormal_blood_homeostasis0.80328366
98MP0009765_abnormal_xenobiotic_induced0.78643488
99MP0002102_abnormal_ear_morphology0.78151508
100MP0001853_heart_inflammation0.78008521
101MP0001188_hyperpigmentation0.77865115
102MP0002938_white_spotting0.77524473
103MP0010094_abnormal_chromosome_stability0.77076087
104MP0002160_abnormal_reproductive_system0.76854562
105MP0000627_abnormal_mammary_gland0.73840791
106MP0008260_abnormal_autophagy0.73358029
107MP0005384_cellular_phenotype0.73095357
108MP0001216_abnormal_epidermal_layer0.72806304
109MP0003011_delayed_dark_adaptation0.72237382
110MP0004215_abnormal_myocardial_fiber0.71999976
111MP0005395_other_phenotype0.71910787
112MP0004782_abnormal_surfactant_physiolog0.71278977
113MP0002006_tumorigenesis0.71127579
114MP0001727_abnormal_embryo_implantation0.70854233
115MP0002254_reproductive_system_inflammat0.70336858
116MP0009785_altered_susceptibility_to0.66834457
117MP0004147_increased_porphyrin_level0.66311926
118MP0003119_abnormal_digestive_system0.65113501
119MP0003436_decreased_susceptibility_to0.64899771
120MP0002132_abnormal_respiratory_system0.64566637
121MP0006072_abnormal_retinal_apoptosis0.64114533
122MP0002090_abnormal_vision0.63697402
123MP0008789_abnormal_olfactory_epithelium0.63186676
124MP0000377_abnormal_hair_follicle0.62996307
125MP0000537_abnormal_urethra_morphology0.62963442
126MP0000383_abnormal_hair_follicle0.62639312
127MP0003943_abnormal_hepatobiliary_system0.62380421
128MP0002078_abnormal_glucose_homeostasis0.61766593
129MP0003698_abnormal_male_reproductive0.61337291
130MP0001845_abnormal_inflammatory_respons0.60242952
131MP0004233_abnormal_muscle_weight0.59402307
132MP0003111_abnormal_nucleus_morphology0.59400252
133MP0005464_abnormal_platelet_physiology0.59142828
134MP0004808_abnormal_hematopoietic_stem0.57826248
135MP0006054_spinal_hemorrhage0.56717987
136MP0002971_abnormal_brown_adipose0.56476745
137MP0002092_abnormal_eye_morphology0.56002901
138MP0001191_abnormal_skin_condition0.55368720
139MP0004185_abnormal_adipocyte_glucose0.55339180
140MP0002928_abnormal_bile_duct0.53498457
141MP0001835_abnormal_antigen_presentation0.52708300
142MP0010155_abnormal_intestine_physiology0.52306293
143MP0008058_abnormal_DNA_repair0.51307741
144MP0001765_abnormal_ion_homeostasis0.51181367
145MP0003077_abnormal_cell_cycle0.50222072
146MP0002396_abnormal_hematopoietic_system0.46601586
147MP0005666_abnormal_adipose_tissue0.46263304
148MP0003221_abnormal_cardiomyocyte_apopto0.46005702
149MP0010352_gastrointestinal_tract_polyps0.45189584
150MP0008873_increased_physiological_sensi0.44523408
151MP0002135_abnormal_kidney_morphology0.44398205
152MP0010234_abnormal_vibrissa_follicle0.44066915
153MP0005334_abnormal_fat_pad0.43942100
154MP0005025_abnormal_response_to0.42705913
155MP0003638_abnormal_response/metabolism_0.42103843
156MP0009672_abnormal_birth_weight0.41591332
157MP0003646_muscle_fatigue0.41142800
158MP0008057_abnormal_DNA_replication0.40413497
159MP0005535_abnormal_body_temperature0.39817540
160MP0004130_abnormal_muscle_cell0.38362442
161MP0009115_abnormal_fat_cell0.38078160
162MP0002796_impaired_skin_barrier0.37923397
163MP0001119_abnormal_female_reproductive0.37331768
164MP0000689_abnormal_spleen_morphology0.37294112
165MP0010368_abnormal_lymphatic_system0.37177584
166MP0002166_altered_tumor_susceptibility0.37062975
167MP0002019_abnormal_tumor_incidence0.36097381
168MP0010307_abnormal_tumor_latency0.36058411

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.70686941
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.68344514
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.34255985
4Hypobetalipoproteinemia (HP:0003563)5.09259314
5Hyperglycinuria (HP:0003108)4.91199881
6Prolonged partial thromboplastin time (HP:0003645)4.69125897
7Deep venous thrombosis (HP:0002625)4.60684452
8Xanthomatosis (HP:0000991)4.56889927
9Hyperglycinemia (HP:0002154)4.55175814
10Chromosomal breakage induced by crosslinking agents (HP:0003221)4.46451412
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.41490510
12Hyperammonemia (HP:0001987)4.40555748
13Abnormality of glycine metabolism (HP:0010895)4.39607530
14Abnormality of serine family amino acid metabolism (HP:0010894)4.39607530
15Chromsome breakage (HP:0040012)4.37706534
16Abnormality of aspartate family amino acid metabolism (HP:0010899)4.15652130
17Hypoglycemic coma (HP:0001325)4.13281662
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.01756008
19Abnormality of fatty-acid metabolism (HP:0004359)4.01309073
20Abnormality of pyrimidine metabolism (HP:0004353)3.91766241
21Ketosis (HP:0001946)3.89032910
22Hypolipoproteinemia (HP:0010981)3.76328363
23Gout (HP:0001997)3.71306782
24Abnormality of methionine metabolism (HP:0010901)3.69410718
25Hyperlipoproteinemia (HP:0010980)3.63510494
26Fat malabsorption (HP:0002630)3.63468319
27Abnormality of nucleobase metabolism (HP:0010932)3.57945228
28Generalized aminoaciduria (HP:0002909)3.50290314
29Abnormality of chromosome stability (HP:0003220)3.47736881
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.41633000
31Abnormality of purine metabolism (HP:0004352)3.41034722
32Complement deficiency (HP:0004431)3.41029341
33Proximal tubulopathy (HP:0000114)3.40935043
34Abnormality of serum amino acid levels (HP:0003112)3.40445368
35Joint hemorrhage (HP:0005261)3.39549462
36Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.35787741
37Dicarboxylic aciduria (HP:0003215)3.29795563
38Abnormality of dicarboxylic acid metabolism (HP:0010995)3.29795563
39Ketoacidosis (HP:0001993)3.22356077
40Epidermoid cyst (HP:0200040)3.22164305
41Abnormality of the common coagulation pathway (HP:0010990)3.20825024
42Meckel diverticulum (HP:0002245)3.20393855
43Colon cancer (HP:0003003)3.19512105
44Abnormality of the preputium (HP:0100587)3.17500962
45Conjugated hyperbilirubinemia (HP:0002908)3.12909422
46Hypoalphalipoproteinemia (HP:0003233)3.09033812
47Abnormality of glycolysis (HP:0004366)3.08273823
48Abnormality of the intrinsic pathway (HP:0010989)3.07155311
49Microvesicular hepatic steatosis (HP:0001414)3.05635203
50Increased serum pyruvate (HP:0003542)3.05628272
51Lethargy (HP:0001254)3.00440459
52Nephroblastoma (Wilms tumor) (HP:0002667)3.00375187
53Abnormality of the ileum (HP:0001549)3.00222339
54Metabolic acidosis (HP:0001942)2.99676490
55Delayed CNS myelination (HP:0002188)2.97929016
56Rhabdomyosarcoma (HP:0002859)2.93690350
57Multiple enchondromatosis (HP:0005701)2.93286329
58Hyperbilirubinemia (HP:0002904)2.90935090
59Embryonal renal neoplasm (HP:0011794)2.86311682
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.82619312
61Birth length less than 3rd percentile (HP:0003561)2.81742765
62Steatorrhea (HP:0002570)2.80213256
63Increased purine levels (HP:0004368)2.80117196
64Hyperuricemia (HP:0002149)2.80117196
65Abnormal lung lobation (HP:0002101)2.78831295
66Duodenal stenosis (HP:0100867)2.77664628
67Small intestinal stenosis (HP:0012848)2.77664628
68Abnormality of the labia minora (HP:0012880)2.77432373
69Abnormality of the anterior horn cell (HP:0006802)2.72309610
70Degeneration of anterior horn cells (HP:0002398)2.72309610
71Glycosuria (HP:0003076)2.66420654
72Abnormality of urine glucose concentration (HP:0011016)2.66420654
73Medulloblastoma (HP:0002885)2.66411989
74Cerebral edema (HP:0002181)2.65988343
75Nausea (HP:0002018)2.63390492
76Renal cortical cysts (HP:0000803)2.57721155
77Acute encephalopathy (HP:0006846)2.55618671
78Hypercholesterolemia (HP:0003124)2.55500404
79Reticulocytopenia (HP:0001896)2.51457987
80Type I transferrin isoform profile (HP:0003642)2.51366247
81Ependymoma (HP:0002888)2.51149688
82Cortical dysplasia (HP:0002539)2.47590538
83Myelodysplasia (HP:0002863)2.44758939
84Pancreatic islet-cell hyperplasia (HP:0004510)2.44724914
85Hepatocellular carcinoma (HP:0001402)2.43979894
86Abnormality of complement system (HP:0005339)2.43456519
87Acanthocytosis (HP:0001927)2.40940367
88Abnormality of the duodenum (HP:0002246)2.40829036
89Vascular calcification (HP:0004934)2.40085654
90Spastic diplegia (HP:0001264)2.39963343
91Neoplasm of the colon (HP:0100273)2.35846059
92Malnutrition (HP:0004395)2.27197658
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26879062
94Abnormality of alanine metabolism (HP:0010916)2.26879062
95Hyperalaninemia (HP:0003348)2.26879062
96Ovarian neoplasm (HP:0100615)2.26073690
97Neoplasm of the adrenal gland (HP:0100631)2.25373234
98Vomiting (HP:0002013)2.25179867
99Biliary tract neoplasm (HP:0100574)2.24660925
100Volvulus (HP:0002580)2.24130450
101Abnormal glycosylation (HP:0012345)2.23777259
102Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.23777259
103Abnormal protein N-linked glycosylation (HP:0012347)2.23777259
104Abnormal protein glycosylation (HP:0012346)2.23777259
105Acute necrotizing encephalopathy (HP:0006965)2.23561603
106Pancreatitis (HP:0001733)2.22513852
107Abnormality of proline metabolism (HP:0010907)2.22347303
108Hydroxyprolinuria (HP:0003080)2.22347303
109Hypoglycemic seizures (HP:0002173)2.20837724
110Alkalosis (HP:0001948)2.17726647
111Stenosis of the external auditory canal (HP:0000402)2.15482901
112Gonadotropin excess (HP:0000837)2.13252215
113Breast carcinoma (HP:0003002)2.11258918
114Irritability (HP:0000737)2.10761440
115Increased hepatocellular lipid droplets (HP:0006565)2.10229948
116Acute hepatic failure (HP:0006554)2.09650540
117Cardiovascular calcification (HP:0011915)2.07052526
118Agnosia (HP:0010524)2.06589491
119Increased serum lactate (HP:0002151)2.06006454
120Enlarged kidneys (HP:0000105)2.05658386
121Systemic lupus erythematosus (HP:0002725)2.04406995
122Hepatic necrosis (HP:0002605)2.04033851
123Abnormal mitochondria in muscle tissue (HP:0008316)2.02457948
124Sloping forehead (HP:0000340)1.98949585
125Increased CSF lactate (HP:0002490)1.98932758
126Increased nuchal translucency (HP:0010880)1.98898627
127Aplastic anemia (HP:0001915)1.98701222
128Spontaneous abortion (HP:0005268)1.97908164
129Elevated hepatic transaminases (HP:0002910)1.97878601
130Horseshoe kidney (HP:0000085)1.97821980
131Progressive external ophthalmoplegia (HP:0000590)1.97281482
132Glioma (HP:0009733)1.97018686
133Postnatal microcephaly (HP:0005484)1.96980612
134Uterine neoplasm (HP:0010784)1.96197276
135IgM deficiency (HP:0002850)1.96023282
136Reduced antithrombin III activity (HP:0001976)1.95214093
137Abnormal enzyme/coenzyme activity (HP:0012379)1.94223323
138Absent radius (HP:0003974)1.94215564
139Late onset (HP:0003584)1.93673168
140Palpitations (HP:0001962)1.92422861
141Neoplasm of the small intestine (HP:0100833)1.92321440
142Sensorimotor neuropathy (HP:0007141)1.92194155
143Myocardial infarction (HP:0001658)1.91506235
144Lipid accumulation in hepatocytes (HP:0006561)1.90550880
145Megaloblastic anemia (HP:0001889)1.89602134
146Opisthotonus (HP:0002179)1.89226021
147Esophageal varix (HP:0002040)1.88406788
148Lactic acidosis (HP:0003128)1.86231300
149Clubbing of toes (HP:0100760)1.85595796
150Sparse eyelashes (HP:0000653)1.85171863
151Thrombophlebitis (HP:0004418)1.83799048
152Neoplasm of the rectum (HP:0100743)1.83545344
153Hyperglycemia (HP:0003074)1.83304990
154Macrocytic anemia (HP:0001972)1.82712865
155Adenoma sebaceum (HP:0009720)1.82213499
156Angiofibromas (HP:0010615)1.82213499
157Abnormal cartilage morphology (HP:0002763)1.82171348
158Hyperinsulinemic hypoglycemia (HP:0000825)1.80521727
159Dyschromatopsia (HP:0007641)1.80487311
160Recurrent gram-negative bacterial infections (HP:0005420)1.80085311
161Exercise-induced muscle cramps (HP:0003710)1.79452982
162Abnormality of transition element cation homeostasis (HP:0011030)1.78125012
163Skin nodule (HP:0200036)1.77181272
164Neonatal onset (HP:0003623)1.76986916
165Hypochromic microcytic anemia (HP:0004840)1.76769843
166Selective tooth agenesis (HP:0001592)1.76274797
167Carpal bone hypoplasia (HP:0001498)1.76218318
168Pancytopenia (HP:0001876)1.76117199
169Progressive macrocephaly (HP:0004481)1.76036632
170Rhabdomyolysis (HP:0003201)1.76013140
171Aplasia involving forearm bones (HP:0009822)1.75513003
172Absent forearm bone (HP:0003953)1.75513003
173Abnormality of alkaline phosphatase activity (HP:0004379)1.75217645
174Thyroid carcinoma (HP:0002890)1.74292195
175Symptomatic seizures (HP:0011145)1.74203866
176Homocystinuria (HP:0002156)1.74037256
177Abnormality of homocysteine metabolism (HP:0010919)1.74037256
178Abnormality of vitamin metabolism (HP:0100508)1.73773258
179Choanal atresia (HP:0000453)1.73333663
180Triphalangeal thumb (HP:0001199)1.73182760
181Brushfield spots (HP:0001088)1.72136187
182Posterior subcapsular cataract (HP:0007787)1.69844335
183Proximal placement of thumb (HP:0009623)1.69283407
184Methylmalonic aciduria (HP:0012120)1.68245823
185Abnormality of iron homeostasis (HP:0011031)1.67753498
186Rickets (HP:0002748)1.67598633
187Poikilocytosis (HP:0004447)1.66587166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.18158568
2PBK3.44175898
3FRK2.41350080
4TRIM282.39262965
5FGFR42.29180354
6STK162.26017442
7MKNK12.23213392
8PLK32.20316299
9NEK12.15813222
10INSRR2.14136138
11EIF2AK12.13901695
12ACVR1B2.11297482
13FLT32.10456166
14ERN12.10443643
15VRK22.06583458
16TAF12.00136064
17STK38L1.93899321
18WEE11.93023720
19MKNK21.87950044
20PDK41.69300039
21PDK31.69300039
22NEK91.69053170
23EIF2AK31.67342586
24BRSK21.67272482
25TYK21.65385741
26MAP3K141.61028607
27KDR1.59085789
28BCR1.57119536
29SCYL21.55485548
30WNK31.53372165
31BUB11.52819604
32NME21.49471449
33MAP2K31.45766391
34MAP3K31.43257758
35ERBB41.42955671
36LATS11.42744218
37PDK21.42575427
38PIK3CG1.39179846
39MAPK111.36527955
40SIK11.29759723
41EPHA21.26880769
42ERBB31.26570626
43IRAK31.25658335
44ZAK1.23353409
45TTK1.14356178
46TAOK31.12366883
47PKN21.12277634
48MST1R1.09615912
49RPS6KA41.09348712
50NME11.09019124
51CDK41.08906330
52PLK41.07963200
53CHEK21.04522421
54PAK41.02554616
55BMPR1B0.99175126
56MST40.98571606
57AKT30.98076410
58SRPK10.97803317
59MAP3K120.97483373
60EIF2AK20.94709093
61BRSK10.91450536
62CDK190.90065427
63NEK20.88533972
64PINK10.87781893
65STK100.87224930
66MAP4K10.85535598
67AURKB0.85174849
68TBK10.83883904
69DYRK30.82321789
70CDK60.81734205
71ABL20.80387902
72TEC0.80060980
73STK30.80029005
74PLK10.79430321
75TXK0.78524178
76CHEK10.77436835
77TAOK20.77157414
78PIM10.76188745
79ATM0.75386872
80MAP2K60.74668532
81IRAK40.74238172
82JAK30.74095158
83PRKAA20.73927500
84CCNB10.73762364
85TSSK60.73091672
86ALK0.73052379
87OBSCN0.71047669
88NUAK10.70135308
89TGFBR10.69142517
90TIE10.68204890
91CDC70.67585904
92PNCK0.67263147
93CSNK1G10.66151528
94PLK20.64432425
95STK240.64124023
96CDK80.63632351
97IKBKE0.62969377
98STK40.62661062
99JAK10.62538645
100GRK60.61449630
101MET0.61332789
102GRK10.60943517
103TGFBR20.60082612
104MAP3K80.59756923
105ZAP700.59664877
106CHUK0.59525328
107FGFR10.59391319
108MAP3K110.58867170
109MAP3K50.58804005
110CDK70.58476587
111CSNK1G30.58343953
112PASK0.58241695
113DAPK10.57721738
114STK390.55669040
115TNIK0.55444397
116MYLK0.55299082
117ITK0.54638680
118RPS6KB20.53846635
119NLK0.53811458
120CSNK2A20.53706524
121AURKA0.52696668
122WNK40.51682397
123ATR0.50518546
124BLK0.50149592
125PTK60.49658591
126MAPKAPK30.49633210
127JAK20.48977524
128PRKAA10.48871454
129CSNK1A1L0.46984250
130IKBKB0.46339162
131VRK10.46022573
132YES10.45598393
133CSNK2A10.44353345
134BTK0.41955289
135CLK10.41758128
136MELK0.41677250
137CSNK1G20.40608396
138OXSR10.40399116
139CDK10.38973936
140BMPR20.38856794
141SIK30.35754042
142CSNK1E0.34195529
143CDK30.33657421
144CDK20.32253667
145CDK90.31945320
146MAP4K20.30304330
147FER0.29522580
148MAP3K100.28547134
149MATK0.27850089
150EGFR0.22764845

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.44200069
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.11242516
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.84338898
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.79816433
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.53131205
6Tryptophan metabolism_Homo sapiens_hsa003802.52852132
7Fatty acid degradation_Homo sapiens_hsa000712.52771592
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.41536791
9Arginine biosynthesis_Homo sapiens_hsa002202.40705707
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.40429580
11Propanoate metabolism_Homo sapiens_hsa006402.26155687
12Nitrogen metabolism_Homo sapiens_hsa009102.17310963
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.16739351
14Peroxisome_Homo sapiens_hsa041462.14729500
15Spliceosome_Homo sapiens_hsa030402.12945923
16Butanoate metabolism_Homo sapiens_hsa006502.05559001
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.93446804
18Ribosome_Homo sapiens_hsa030101.91461682
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.90035583
20Fanconi anemia pathway_Homo sapiens_hsa034601.89713754
21Selenocompound metabolism_Homo sapiens_hsa004501.89706421
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.88322699
23Complement and coagulation cascades_Homo sapiens_hsa046101.86963619
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.80585865
25Folate biosynthesis_Homo sapiens_hsa007901.78921521
26beta-Alanine metabolism_Homo sapiens_hsa004101.77231735
27Fatty acid metabolism_Homo sapiens_hsa012121.68742282
28Histidine metabolism_Homo sapiens_hsa003401.64073986
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.63226875
30Pyruvate metabolism_Homo sapiens_hsa006201.62648429
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61893932
32Basal transcription factors_Homo sapiens_hsa030221.61664393
33Caffeine metabolism_Homo sapiens_hsa002321.59675596
34Chemical carcinogenesis_Homo sapiens_hsa052041.58684154
35PPAR signaling pathway_Homo sapiens_hsa033201.54888876
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.54612978
37Carbon metabolism_Homo sapiens_hsa012001.54352082
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.53803526
39Retinol metabolism_Homo sapiens_hsa008301.51785411
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.50053219
41One carbon pool by folate_Homo sapiens_hsa006701.47675098
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46911886
43Biosynthesis of amino acids_Homo sapiens_hsa012301.46542810
44Phenylalanine metabolism_Homo sapiens_hsa003601.41167387
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40653508
46mRNA surveillance pathway_Homo sapiens_hsa030151.38738961
47Starch and sucrose metabolism_Homo sapiens_hsa005001.37550013
48Vitamin digestion and absorption_Homo sapiens_hsa049771.35607283
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35206766
50Sulfur metabolism_Homo sapiens_hsa009201.35177529
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30502468
52Parkinsons disease_Homo sapiens_hsa050121.22101780
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.18642998
54Staphylococcus aureus infection_Homo sapiens_hsa051501.16240634
55Tyrosine metabolism_Homo sapiens_hsa003501.15560520
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.14795880
57Vitamin B6 metabolism_Homo sapiens_hsa007501.13587193
58Oxidative phosphorylation_Homo sapiens_hsa001901.12083634
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09694485
60Fat digestion and absorption_Homo sapiens_hsa049751.07990064
61Bile secretion_Homo sapiens_hsa049761.06828711
62Arginine and proline metabolism_Homo sapiens_hsa003301.05469872
63Glutathione metabolism_Homo sapiens_hsa004801.02936440
64Fatty acid elongation_Homo sapiens_hsa000621.02356738
65Pentose phosphate pathway_Homo sapiens_hsa000300.99406768
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94189288
67ABC transporters_Homo sapiens_hsa020100.90661010
68Huntingtons disease_Homo sapiens_hsa050160.89590499
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89363594
70Sulfur relay system_Homo sapiens_hsa041220.86893892
71Oocyte meiosis_Homo sapiens_hsa041140.83893203
72N-Glycan biosynthesis_Homo sapiens_hsa005100.80851135
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79101101
74Lysine degradation_Homo sapiens_hsa003100.78124971
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76422666
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71805582
77DNA replication_Homo sapiens_hsa030300.68107803
78Thyroid cancer_Homo sapiens_hsa052160.66942140
79Fructose and mannose metabolism_Homo sapiens_hsa000510.66052398
80Glycerolipid metabolism_Homo sapiens_hsa005610.62415932
81Metabolic pathways_Homo sapiens_hsa011000.61914561
82Galactose metabolism_Homo sapiens_hsa000520.58601237
83Proteasome_Homo sapiens_hsa030500.57879218
84Pyrimidine metabolism_Homo sapiens_hsa002400.57005152
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56015149
86Steroid biosynthesis_Homo sapiens_hsa001000.54765618
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54144898
88Mismatch repair_Homo sapiens_hsa034300.51513623
89Alzheimers disease_Homo sapiens_hsa050100.51307793
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51047242
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49807087
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46917832
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44934032
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39260813
95Renin-angiotensin system_Homo sapiens_hsa046140.37537353
96Epstein-Barr virus infection_Homo sapiens_hsa051690.35110274
97Viral carcinogenesis_Homo sapiens_hsa052030.30512149
98Base excision repair_Homo sapiens_hsa034100.27886998
99Systemic lupus erythematosus_Homo sapiens_hsa053220.27729143
100Nucleotide excision repair_Homo sapiens_hsa034200.25134104
101Homologous recombination_Homo sapiens_hsa034400.24931691
102Adherens junction_Homo sapiens_hsa045200.24318593
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.21171744
104TGF-beta signaling pathway_Homo sapiens_hsa043500.20039944
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19133449
106RNA polymerase_Homo sapiens_hsa030200.18961709
107Fatty acid biosynthesis_Homo sapiens_hsa000610.18661168
108Legionellosis_Homo sapiens_hsa051340.16171372
109Purine metabolism_Homo sapiens_hsa002300.15914570
110Linoleic acid metabolism_Homo sapiens_hsa005910.15756769
111Insulin resistance_Homo sapiens_hsa049310.13668769
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.13535302
113RNA transport_Homo sapiens_hsa030130.13139847
114Alcoholism_Homo sapiens_hsa050340.12029025
115Protein export_Homo sapiens_hsa030600.11971034
116Tight junction_Homo sapiens_hsa045300.11654680
117Other glycan degradation_Homo sapiens_hsa005110.10843478
118Regulation of autophagy_Homo sapiens_hsa041400.09726041
119Arachidonic acid metabolism_Homo sapiens_hsa005900.08487528
120RNA degradation_Homo sapiens_hsa030180.07152088
121p53 signaling pathway_Homo sapiens_hsa041150.07061278
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.06980961
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.06079035
124Non-homologous end-joining_Homo sapiens_hsa034500.05724655
125Cell cycle_Homo sapiens_hsa041100.04842796
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.04542282

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