LYPLA1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.28399698
2regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)6.23807183
3regulation of RIG-I signaling pathway (GO:0039535)6.20564320
4proteasome assembly (GO:0043248)6.15583711
5positive regulation of hormone biosynthetic process (GO:0046886)6.14932314
6negative regulation of heart rate (GO:0010459)6.10981792
7positive regulation of fibroblast migration (GO:0010763)6.03396892
8regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00435.89239516
9ATP synthesis coupled proton transport (GO:0015986)5.50639335
10energy coupled proton transport, down electrochemical gradient (GO:0015985)5.50639335
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.96074150
12positive regulation of glycolytic process (GO:0045821)4.95104030
13regulation of glomerular filtration (GO:0003093)4.81802833
14establishment of protein localization to mitochondrial membrane (GO:0090151)4.75711395
15respiratory electron transport chain (GO:0022904)4.67105339
16electron transport chain (GO:0022900)4.58143366
17histone mRNA metabolic process (GO:0008334)4.58120275
18protein polyglutamylation (GO:0018095)4.48575717
19positive regulation of hormone metabolic process (GO:0032352)4.43993394
20positive regulation of protein sumoylation (GO:0033235)4.40502588
21cellular response to nicotine (GO:0071316)4.18846498
22ribosomal small subunit assembly (GO:0000028)3.95299614
23protein complex biogenesis (GO:0070271)3.92981282
24mRNA cleavage (GO:0006379)3.91129742
25spliceosomal snRNP assembly (GO:0000387)3.90692825
26regulation of circadian sleep/wake cycle, sleep (GO:0045187)3.87541912
27regulation of circadian sleep/wake cycle (GO:0042749)3.87541912
28NADH dehydrogenase complex assembly (GO:0010257)3.80300079
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.80300079
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.80300079
31translational termination (GO:0006415)3.60431555
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.58056461
33oxidative phosphorylation (GO:0006119)3.57934279
34mitochondrial respiratory chain complex assembly (GO:0033108)3.57462415
35protein neddylation (GO:0045116)3.56496352
36ATP biosynthetic process (GO:0006754)3.54017211
37cotranslational protein targeting to membrane (GO:0006613)3.51834505
38pteridine-containing compound biosynthetic process (GO:0042559)3.51628537
39respiratory chain complex IV assembly (GO:0008535)3.51521354
40viral transcription (GO:0019083)3.50407202
41nerve growth factor signaling pathway (GO:0038180)3.48975059
42hydrogen ion transmembrane transport (GO:1902600)3.47565152
43protein targeting to ER (GO:0045047)3.45771508
44spliceosomal complex assembly (GO:0000245)3.45292392
45protein localization to endoplasmic reticulum (GO:0070972)3.32525787
46maturation of SSU-rRNA (GO:0030490)3.31397114
47negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.30547100
48purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.28992566
49mRNA transcription from RNA polymerase II promoter (GO:0042789)3.28847229
50fucose catabolic process (GO:0019317)3.28562739
51L-fucose metabolic process (GO:0042354)3.28562739
52L-fucose catabolic process (GO:0042355)3.28562739
53cytochrome complex assembly (GO:0017004)3.26055880
54cullin deneddylation (GO:0010388)3.25626041
55establishment of protein localization to endoplasmic reticulum (GO:0072599)3.25547394
56purine nucleoside triphosphate biosynthetic process (GO:0009145)3.24112165
57ribonucleoprotein complex disassembly (GO:0032988)3.23871346
58regulation of mitochondrial translation (GO:0070129)3.22296893
59response to testosterone (GO:0033574)3.19302677
60behavioral response to nicotine (GO:0035095)3.16727457
61renal system process involved in regulation of blood volume (GO:0001977)3.16614816
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10847878
63L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.10550604
64regulation of renal sodium excretion (GO:0035813)3.09503259
65nucleoside diphosphate catabolic process (GO:0009134)3.08028065
66termination of RNA polymerase III transcription (GO:0006386)3.05676371
67transcription elongation from RNA polymerase III promoter (GO:0006385)3.05676371
68response to pheromone (GO:0019236)3.04431207
69proton transport (GO:0015992)3.03114886
70DNA double-strand break processing (GO:0000729)3.02733684
71folic acid-containing compound biosynthetic process (GO:0009396)3.02414168
72regulation of urine volume (GO:0035809)3.02208038
73regulation of helicase activity (GO:0051095)3.01563455
74circadian sleep/wake cycle process (GO:0022410)3.01159293
75regulation of excretion (GO:0044062)2.99078773
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.99067873
77regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.97375924
78purine nucleoside monophosphate biosynthetic process (GO:0009127)2.96616295
79purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.96616295
80hydrogen transport (GO:0006818)2.96584027
81positive regulation of erythrocyte differentiation (GO:0045648)2.96400073
82mitochondrial DNA replication (GO:0006264)2.95767727
83positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.95167937
84intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.93554394
85signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.93554394
86protein deneddylation (GO:0000338)2.93383850
87exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.92431283
88signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.92154131
89signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.92154131
90signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.92154131
91ribosomal large subunit biogenesis (GO:0042273)2.90650289
92nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.89786631
93translational elongation (GO:0006414)2.88562803
94translation (GO:0006412)2.87331284
95positive regulation of heart rate (GO:0010460)2.87255405
96regulation of protein sumoylation (GO:0033233)2.87027352
97ribonucleoside triphosphate biosynthetic process (GO:0009201)2.86895171
98negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.85252841
99negative regulation of ligase activity (GO:0051352)2.85252841
100termination of RNA polymerase II transcription (GO:0006369)2.83944539

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.68758196
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.38380721
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.14186208
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.99916029
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.77368694
6FLI1_27457419_Chip-Seq_LIVER_Mouse3.76599377
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.20619869
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.17056312
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.98659943
10ELK1_19687146_ChIP-ChIP_HELA_Human2.96859175
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.95355078
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.85623413
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.76885815
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.76766784
15VDR_23849224_ChIP-Seq_CD4+_Human2.72423119
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.70138946
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.61905170
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.53680468
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53566939
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.46497803
21ZNF274_21170338_ChIP-Seq_K562_Hela2.39688062
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.23922944
23FOXP3_21729870_ChIP-Seq_TREG_Human2.12445654
24PCGF2_27294783_Chip-Seq_NPCs_Mouse2.04079897
25HOXB4_20404135_ChIP-ChIP_EML_Mouse2.00114150
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.94707650
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.87298984
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86895779
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.86203536
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.80125658
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78442153
32IRF1_19129219_ChIP-ChIP_H3396_Human1.70957583
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.67597350
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65872033
35TTF2_22483619_ChIP-Seq_HELA_Human1.63187462
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.61112237
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.58238343
38DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.55882671
39TP53_22573176_ChIP-Seq_HFKS_Human1.52587417
40ELK1_22589737_ChIP-Seq_MCF10A_Human1.52263203
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51609395
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.48275798
43DCP1A_22483619_ChIP-Seq_HELA_Human1.44456508
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42141011
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41705943
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40275423
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40180005
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35705267
49HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30803324
50EWS_26573619_Chip-Seq_HEK293_Human1.25669846
51VDR_22108803_ChIP-Seq_LS180_Human1.24582871
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24390259
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24116209
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.23754147
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.21807086
56MYC_18940864_ChIP-ChIP_HL60_Human1.20353624
57TAF15_26573619_Chip-Seq_HEK293_Human1.20284152
58ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19604894
59GABP_19822575_ChIP-Seq_HepG2_Human1.18565260
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.18431747
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17289628
62CRX_20693478_ChIP-Seq_RETINA_Mouse1.14309047
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.13947488
64PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13937071
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12518759
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09517766
67FUS_26573619_Chip-Seq_HEK293_Human1.08923072
68AR_20517297_ChIP-Seq_VCAP_Human1.03656200
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03264847
70ERG_20517297_ChIP-Seq_VCAP_Human1.03085142
71IGF1R_20145208_ChIP-Seq_DFB_Human1.00770709
72NANOG_16153702_ChIP-ChIP_HESCs_Human1.00644209
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00470857
74KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97656881
75GATA3_26560356_Chip-Seq_TH2_Human0.96502214
76NANOG_19829295_ChIP-Seq_ESCs_Human0.95846711
77SOX2_19829295_ChIP-Seq_ESCs_Human0.95846711
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95072870
79CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94778119
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93720644
81POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93683624
82FOXA1_25329375_ChIP-Seq_VCAP_Human0.92025555
83FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92025555
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91963331
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91552898
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90849200
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87510698
88CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86603181
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85568909
90P300_19829295_ChIP-Seq_ESCs_Human0.85052876
91YY1_21170310_ChIP-Seq_MESCs_Mouse0.83931022
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.82619290
93LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81778202
94SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.81185817
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.80084340
96TCF3_18692474_ChIP-Seq_MEFs_Mouse0.78634400
97SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77737581
98XRN2_22483619_ChIP-Seq_HELA_Human0.77698083
99RBPJ_21746931_ChIP-Seq_IB4_Human0.77532747
100CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76477526

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation5.16294341
2MP0005499_abnormal_olfactory_system3.02107614
3MP0005394_taste/olfaction_phenotype3.02107614
4MP0008789_abnormal_olfactory_epithelium2.94075045
5MP0002234_abnormal_pharynx_morphology2.93921298
6MP0002102_abnormal_ear_morphology2.82433822
7MP0005075_abnormal_melanosome_morpholog2.76390046
8MP0002822_catalepsy2.50160750
9MP0006292_abnormal_olfactory_placode2.46269158
10MP0001529_abnormal_vocalization2.45063987
11MP0005408_hypopigmentation2.38989388
12MP0009379_abnormal_foot_pigmentation2.30711674
13MP0001984_abnormal_olfaction2.24248168
14MP0006036_abnormal_mitochondrial_physio2.18933325
15MP0004270_analgesia2.17877986
16MP0006035_abnormal_mitochondrial_morpho2.08006159
17MP0008995_early_reproductive_senescence2.03017622
18MP0001881_abnormal_mammary_gland2.00709205
19MP0002163_abnormal_gland_morphology1.96887543
20MP0006276_abnormal_autonomic_nervous1.93346492
21MP0002796_impaired_skin_barrier1.84300019
22MP0003693_abnormal_embryo_hatching1.80709107
23MP0000749_muscle_degeneration1.76874289
24MP0004142_abnormal_muscle_tone1.70450140
25MP0008058_abnormal_DNA_repair1.63723038
26MP0003786_premature_aging1.63050429
27MP0003186_abnormal_redox_activity1.62141974
28MP0001790_abnormal_immune_system1.60877155
29MP0005387_immune_system_phenotype1.60877155
30MP0004381_abnormal_hair_follicle1.57464016
31MP0002938_white_spotting1.49509748
32MP0005646_abnormal_pituitary_gland1.48424988
33MP0003011_delayed_dark_adaptation1.46304911
34MP0002090_abnormal_vision1.46105867
35MP0005084_abnormal_gallbladder_morpholo1.45189540
36MP0004145_abnormal_muscle_electrophysio1.43987334
37MP0003195_calcinosis1.41803541
38MP0002138_abnormal_hepatobiliary_system1.41752138
39MP0002751_abnormal_autonomic_nervous1.41148779
40MP0006072_abnormal_retinal_apoptosis1.36403306
41MP0000627_abnormal_mammary_gland1.36362791
42MP0008877_abnormal_DNA_methylation1.33701035
43MP0001286_abnormal_eye_development1.33559152
44MP0001905_abnormal_dopamine_level1.30195453
45MP0005551_abnormal_eye_electrophysiolog1.29302095
46MP0001919_abnormal_reproductive_system1.26807253
47MP0000631_abnormal_neuroendocrine_gland1.21598236
48MP0005253_abnormal_eye_physiology1.20378681
49MP0002697_abnormal_eye_size1.17843826
50MP0002653_abnormal_ependyma_morphology1.17038901
51MP0002837_dystrophic_cardiac_calcinosis1.15823531
52MP0001188_hyperpigmentation1.14518828
53MP0001485_abnormal_pinna_reflex1.12375355
54MP0005501_abnormal_skin_physiology1.09226921
55MP0002735_abnormal_chemical_nociception1.08945807
56MP0010094_abnormal_chromosome_stability1.08933668
57MP0005379_endocrine/exocrine_gland_phen1.08711293
58MP0002277_abnormal_respiratory_mucosa1.07934551
59MP0000358_abnormal_cell_content/1.04783140
60MP0009745_abnormal_behavioral_response1.04348496
61MP0005389_reproductive_system_phenotype1.03646520
62MP0005410_abnormal_fertilization1.01792460
63MP0000516_abnormal_urinary_system0.97320011
64MP0005367_renal/urinary_system_phenotyp0.97320011
65MP0003718_maternal_effect0.95703085
66MP0000653_abnormal_sex_gland0.94671597
67MP0001486_abnormal_startle_reflex0.94532141
68MP0003936_abnormal_reproductive_system0.94393870
69MP0010368_abnormal_lymphatic_system0.92440637
70MP0010386_abnormal_urinary_bladder0.91590651
71MP0003828_pulmonary_edema0.91382867
72MP0001929_abnormal_gametogenesis0.91082259
73MP0003303_peritoneal_inflammation0.90274400
74MP0002734_abnormal_mechanical_nocicepti0.87801620
75MP0005332_abnormal_amino_acid0.86875316
76MP0001853_heart_inflammation0.84265790
77MP0005195_abnormal_posterior_eye0.82117131
78MP0005391_vision/eye_phenotype0.80411131
79MP0001293_anophthalmia0.80124290
80MP0004742_abnormal_vestibular_system0.79027428
81MP0001963_abnormal_hearing_physiology0.77719922
82MP0004215_abnormal_myocardial_fiber0.77363333
83MP0003880_abnormal_central_pattern0.77362499
84MP0002272_abnormal_nervous_system0.75873651
85MP0002210_abnormal_sex_determination0.75752536
86MP0004885_abnormal_endolymph0.74828998
87MP0000015_abnormal_ear_pigmentation0.72957404
88MP0002752_abnormal_somatic_nervous0.70517852
89MP0002160_abnormal_reproductive_system0.69478094
90MP0005360_urolithiasis0.69442860
91MP0004510_myositis0.68936554
92MP0004957_abnormal_blastocyst_morpholog0.68669114
93MP0001764_abnormal_homeostasis0.66606838
94MP0002132_abnormal_respiratory_system0.65916699
95MP0001800_abnormal_humoral_immune0.65785574
96MP0001119_abnormal_female_reproductive0.65652417
97MP0009046_muscle_twitch0.65440435
98MP0004133_heterotaxia0.64761236
99MP0008961_abnormal_basal_metabolism0.60781300
100MP0002909_abnormal_adrenal_gland0.59948849

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)5.82755728
2Acute necrotizing encephalopathy (HP:0006965)5.82300031
3Acute encephalopathy (HP:0006846)5.60478781
4Abnormal mitochondria in muscle tissue (HP:0008316)5.00020051
5Abnormality of the labia minora (HP:0012880)4.98550464
6Mitochondrial inheritance (HP:0001427)4.86685369
7Progressive macrocephaly (HP:0004481)4.83928282
8Increased CSF lactate (HP:0002490)4.38563312
9Increased hepatocellular lipid droplets (HP:0006565)4.05897934
10Lipid accumulation in hepatocytes (HP:0006561)3.96067827
11Hepatocellular necrosis (HP:0001404)3.94222290
12Cerebral edema (HP:0002181)3.69548191
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.54701979
14Renal Fanconi syndrome (HP:0001994)3.44264016
15Hepatic necrosis (HP:0002605)3.31042652
16Oligodactyly (hands) (HP:0001180)3.17138932
17Meckel diverticulum (HP:0002245)3.13403438
18Aplasia/Hypoplasia of the uvula (HP:0010293)3.10690137
19Molar tooth sign on MRI (HP:0002419)3.00602279
20Abnormality of midbrain morphology (HP:0002418)3.00602279
21Optic disc pallor (HP:0000543)2.98746976
22Medial flaring of the eyebrow (HP:0010747)2.97602756
23Short tibia (HP:0005736)2.97518176
24Leukodystrophy (HP:0002415)2.94425714
25Abnormality of the ileum (HP:0001549)2.84374843
26Bifid tongue (HP:0010297)2.80310164
27Congenital, generalized hypertrichosis (HP:0004540)2.77131941
28Exercise intolerance (HP:0003546)2.74110336
29Reticulocytopenia (HP:0001896)2.74086430
30Congenital primary aphakia (HP:0007707)2.70394322
31Colon cancer (HP:0003003)2.69697528
32Aplasia/Hypoplasia of the tibia (HP:0005772)2.68385222
33Exertional dyspnea (HP:0002875)2.64798745
34Respiratory failure (HP:0002878)2.60799251
35Gait imbalance (HP:0002141)2.58235883
36Nephrogenic diabetes insipidus (HP:0009806)2.58036310
37Respiratory difficulties (HP:0002880)2.56784629
38Ectopic kidney (HP:0000086)2.53618154
39Lactic acidosis (HP:0003128)2.47706456
40Increased serum lactate (HP:0002151)2.46231319
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.44751417
42Oligodactyly (HP:0012165)2.43417990
43Dyschromatopsia (HP:0007641)2.40937069
44Abnormal number of erythroid precursors (HP:0012131)2.40783910
45Poor coordination (HP:0002370)2.35526279
46Abnormality of cells of the erythroid lineage (HP:0012130)2.32730397
47Chorioretinal atrophy (HP:0000533)2.31404697
48Testicular atrophy (HP:0000029)2.30172339
49Horseshoe kidney (HP:0000085)2.28591827
50Abnormality of the preputium (HP:0100587)2.28358670
51Clubbing of toes (HP:0100760)2.27964647
52Hypoplastic labia majora (HP:0000059)2.27672533
53Recurrent corneal erosions (HP:0000495)2.21872343
54Supernumerary spleens (HP:0009799)2.19087268
55Hyperphosphaturia (HP:0003109)2.18688244
56Increased intramyocellular lipid droplets (HP:0012240)2.17440683
57Genital tract atresia (HP:0001827)2.13352442
58Abnormality of the labia (HP:0000058)2.12860563
59Lethargy (HP:0001254)2.12398634
60Microvesicular hepatic steatosis (HP:0001414)2.10800186
61Emotional lability (HP:0000712)2.10309519
62Hyperglycinemia (HP:0002154)2.05743192
63Small intestinal stenosis (HP:0012848)2.04090300
64Duodenal stenosis (HP:0100867)2.04090300
65Sensory axonal neuropathy (HP:0003390)2.03981571
66Abnormality of the labia majora (HP:0012881)2.03722171
67Amniotic constriction ring (HP:0009775)2.02910776
68Abnormality of placental membranes (HP:0011409)2.02910776
69Astigmatism (HP:0000483)2.02887958
70Pancreatic cysts (HP:0001737)2.02178222
71Absent thumb (HP:0009777)2.00683110
72Arthropathy (HP:0003040)1.99334304
73Parakeratosis (HP:0001036)1.98404469
74Abnormality of chromosome stability (HP:0003220)1.97546686
75Abnormality of renal resorption (HP:0011038)1.96771128
76Vaginal atresia (HP:0000148)1.95457747
77Autoamputation (HP:0001218)1.94390395
78Macrocytic anemia (HP:0001972)1.94102511
79Abnormality of urine glucose concentration (HP:0011016)1.93980499
80Glycosuria (HP:0003076)1.93980499
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93769487
82Abnormality of alanine metabolism (HP:0010916)1.93769487
83Hyperalaninemia (HP:0003348)1.93769487
84X-linked dominant inheritance (HP:0001423)1.92580470
85Tubular atrophy (HP:0000092)1.91284593
86Median cleft lip (HP:0000161)1.88228848
87Gout (HP:0001997)1.87841245
88Abnormal urine phosphate concentration (HP:0012599)1.87642918
89Increased muscle lipid content (HP:0009058)1.87582310
90Abnormality of aromatic amino acid family metabolism (HP:0004338)1.84015991
91Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82809102
92Aplasia/Hypoplasia of the sternum (HP:0006714)1.81915676
93Abnormal biliary tract physiology (HP:0012439)1.77852318
94Bile duct proliferation (HP:0001408)1.77852318
95Type II lissencephaly (HP:0007260)1.76338103
96Anhidrosis (HP:0000970)1.76068484
97Abnormality of the anterior horn cell (HP:0006802)1.73957414
98Degeneration of anterior horn cells (HP:0002398)1.73957414
99Blindness (HP:0000618)1.73322450
100Aplasia/hypoplasia of the uterus (HP:0008684)1.72615255

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK14.17573161
2TAOK13.49485219
3MATK3.45386069
4VRK23.31400684
5MAPKAPK33.17584119
6TAOK23.13825365
7NUAK12.84193128
8EIF2AK32.81075758
9FES2.79495536
10EIF2AK12.61354127
11MAP3K112.32279522
12MAP4K22.11063907
13STK161.98981302
14NME11.88644111
15DAPK11.83890050
16EPHA41.70543596
17NLK1.68193229
18MAP3K31.65166557
19DYRK31.62247466
20TAOK31.55673409
21MST41.48784603
22VRK11.47875463
23TRIM281.45494955
24MAP3K101.45035879
25MAP3K121.44272266
26GRK11.41583565
27CSNK1G31.40187356
28PHKG11.35921746
29PHKG21.35921746
30PASK1.33847225
31CSNK1G21.31673593
32PIK3CG1.20875944
33MAP3K51.18954725
34BUB11.18054301
35TSSK61.17088466
36CSNK1A1L1.16941226
37WNK31.14884206
38CCNB11.13680098
39CSNK1G11.10965688
40ADRBK21.04904517
41TLK11.03927103
42SRPK10.96955479
43ZAK0.91323614
44CHEK20.90346375
45CDK30.87788951
46CSK0.85413559
47ERBB20.84796131
48LATS20.80424476
49DYRK20.77801956
50BCKDK0.76986502
51ATR0.76844970
52PLK30.76204873
53SIK30.74875789
54MKNK20.74738769
55MAP2K30.73701009
56NME20.72421034
57ALK0.72066178
58INSRR0.69852768
59DAPK30.67972688
60MYLK0.67888024
61FER0.66232311
62CASK0.62997648
63MAP3K40.59942806
64PINK10.57996621
65BCR0.56131353
66CSNK2A10.56086573
67PDK20.55332390
68GRK70.52410564
69FRK0.50506467
70GRK50.46699557
71MKNK10.46570273
72ILK0.45894371
73OBSCN0.43805027
74MAP2K70.42853966
75EIF2AK20.42282714
76WEE10.41776625
77PIK3CA0.40505315
78AURKA0.37639405
79TYRO30.37608617
80CSNK2A20.37586015
81CAMK2D0.37224755
82PLK20.37066569
83CSNK1E0.36827707
84TIE10.35849958
85MARK30.35745728
86MAPK130.32551236
87IRAK20.30213058
88CAMK2G0.30158068
89OXSR10.29957715
90PLK10.28549709
91PAK40.28331932
92AURKB0.26760277
93PBK0.26587111
94PRKCI0.25784877
95NEK90.25618687
96MAPKAPK50.24479778
97PKN10.24180637
98NEK10.24098695
99RPS6KA40.23824955
100INSR0.23674832

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.68090144
2Proteasome_Homo sapiens_hsa030504.25954962
3Parkinsons disease_Homo sapiens_hsa050124.06244870
4Ribosome_Homo sapiens_hsa030103.98770697
5Protein export_Homo sapiens_hsa030603.22026901
6Huntingtons disease_Homo sapiens_hsa050162.80902861
7Alzheimers disease_Homo sapiens_hsa050102.63201015
8Mismatch repair_Homo sapiens_hsa034302.56331488
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.39905396
10RNA polymerase_Homo sapiens_hsa030202.35872410
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.27397622
12DNA replication_Homo sapiens_hsa030302.05656713
13Cardiac muscle contraction_Homo sapiens_hsa042602.03828276
14Spliceosome_Homo sapiens_hsa030401.99013021
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.91253188
16Homologous recombination_Homo sapiens_hsa034401.90980276
17One carbon pool by folate_Homo sapiens_hsa006701.88184739
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67969644
19Folate biosynthesis_Homo sapiens_hsa007901.60868959
20Fanconi anemia pathway_Homo sapiens_hsa034601.59792669
21Base excision repair_Homo sapiens_hsa034101.58949391
22Chemical carcinogenesis_Homo sapiens_hsa052041.54206980
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.46951218
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32554448
25Fatty acid elongation_Homo sapiens_hsa000621.32372272
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29574884
27Steroid biosynthesis_Homo sapiens_hsa001001.28497196
28Purine metabolism_Homo sapiens_hsa002301.24217541
29RNA degradation_Homo sapiens_hsa030181.23833204
30Type I diabetes mellitus_Homo sapiens_hsa049401.20499750
31Pyrimidine metabolism_Homo sapiens_hsa002401.20443024
32Allograft rejection_Homo sapiens_hsa053301.15550670
33Graft-versus-host disease_Homo sapiens_hsa053321.14413362
34Autoimmune thyroid disease_Homo sapiens_hsa053201.10613262
35RNA transport_Homo sapiens_hsa030131.08483145
36Regulation of autophagy_Homo sapiens_hsa041401.06569902
37Nucleotide excision repair_Homo sapiens_hsa034201.04345074
38Propanoate metabolism_Homo sapiens_hsa006401.02967992
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02574280
40Glutathione metabolism_Homo sapiens_hsa004800.98813609
41Intestinal immune network for IgA production_Homo sapiens_hsa046720.95952796
42Fat digestion and absorption_Homo sapiens_hsa049750.95699053
43Basal transcription factors_Homo sapiens_hsa030220.93486012
44Butanoate metabolism_Homo sapiens_hsa006500.93300481
45Linoleic acid metabolism_Homo sapiens_hsa005910.87027550
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.86513930
47Non-homologous end-joining_Homo sapiens_hsa034500.84971046
48Primary immunodeficiency_Homo sapiens_hsa053400.83592877
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81318998
50Peroxisome_Homo sapiens_hsa041460.80235766
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79811454
52N-Glycan biosynthesis_Homo sapiens_hsa005100.79009528
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77963904
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70551809
55Ether lipid metabolism_Homo sapiens_hsa005650.69694761
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68743972
57Metabolic pathways_Homo sapiens_hsa011000.68136809
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66600479
59Caffeine metabolism_Homo sapiens_hsa002320.65147530
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64318923
61Carbon metabolism_Homo sapiens_hsa012000.60968258
62Asthma_Homo sapiens_hsa053100.59834545
63mRNA surveillance pathway_Homo sapiens_hsa030150.58891202
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56055524
65Antigen processing and presentation_Homo sapiens_hsa046120.55544753
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54619179
67Basal cell carcinoma_Homo sapiens_hsa052170.52987588
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51830866
69Mineral absorption_Homo sapiens_hsa049780.51191892
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47795858
71Phototransduction_Homo sapiens_hsa047440.46256310
72Arachidonic acid metabolism_Homo sapiens_hsa005900.42487003
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41076198
74Pyruvate metabolism_Homo sapiens_hsa006200.40585110
75p53 signaling pathway_Homo sapiens_hsa041150.40531988
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39141886
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39083250
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.38903430
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38675282
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38022013
81Biosynthesis of amino acids_Homo sapiens_hsa012300.37486190
82Thyroid cancer_Homo sapiens_hsa052160.36453789
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.36016005
84Glycerolipid metabolism_Homo sapiens_hsa005610.34604812
85Cell cycle_Homo sapiens_hsa041100.34113330
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33311491
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.32476586
88Retinol metabolism_Homo sapiens_hsa008300.32129524
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30021820
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.26726098
91Arginine and proline metabolism_Homo sapiens_hsa003300.25976071
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25333754
93Fatty acid metabolism_Homo sapiens_hsa012120.23590109
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23066813
95Collecting duct acid secretion_Homo sapiens_hsa049660.23015203
96Pentose phosphate pathway_Homo sapiens_hsa000300.22438508
97Epstein-Barr virus infection_Homo sapiens_hsa051690.21246630
98Systemic lupus erythematosus_Homo sapiens_hsa053220.20357262
99Olfactory transduction_Homo sapiens_hsa047400.17540704
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.17498662

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