

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 6.28399698 |
| 2 | regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531) | 6.23807183 |
| 3 | regulation of RIG-I signaling pathway (GO:0039535) | 6.20564320 |
| 4 | proteasome assembly (GO:0043248) | 6.15583711 |
| 5 | positive regulation of hormone biosynthetic process (GO:0046886) | 6.14932314 |
| 6 | negative regulation of heart rate (GO:0010459) | 6.10981792 |
| 7 | positive regulation of fibroblast migration (GO:0010763) | 6.03396892 |
| 8 | regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043 | 5.89239516 |
| 9 | ATP synthesis coupled proton transport (GO:0015986) | 5.50639335 |
| 10 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.50639335 |
| 11 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.96074150 |
| 12 | positive regulation of glycolytic process (GO:0045821) | 4.95104030 |
| 13 | regulation of glomerular filtration (GO:0003093) | 4.81802833 |
| 14 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.75711395 |
| 15 | respiratory electron transport chain (GO:0022904) | 4.67105339 |
| 16 | electron transport chain (GO:0022900) | 4.58143366 |
| 17 | histone mRNA metabolic process (GO:0008334) | 4.58120275 |
| 18 | protein polyglutamylation (GO:0018095) | 4.48575717 |
| 19 | positive regulation of hormone metabolic process (GO:0032352) | 4.43993394 |
| 20 | positive regulation of protein sumoylation (GO:0033235) | 4.40502588 |
| 21 | cellular response to nicotine (GO:0071316) | 4.18846498 |
| 22 | ribosomal small subunit assembly (GO:0000028) | 3.95299614 |
| 23 | protein complex biogenesis (GO:0070271) | 3.92981282 |
| 24 | mRNA cleavage (GO:0006379) | 3.91129742 |
| 25 | spliceosomal snRNP assembly (GO:0000387) | 3.90692825 |
| 26 | regulation of circadian sleep/wake cycle, sleep (GO:0045187) | 3.87541912 |
| 27 | regulation of circadian sleep/wake cycle (GO:0042749) | 3.87541912 |
| 28 | NADH dehydrogenase complex assembly (GO:0010257) | 3.80300079 |
| 29 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.80300079 |
| 30 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.80300079 |
| 31 | translational termination (GO:0006415) | 3.60431555 |
| 32 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.58056461 |
| 33 | oxidative phosphorylation (GO:0006119) | 3.57934279 |
| 34 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.57462415 |
| 35 | protein neddylation (GO:0045116) | 3.56496352 |
| 36 | ATP biosynthetic process (GO:0006754) | 3.54017211 |
| 37 | cotranslational protein targeting to membrane (GO:0006613) | 3.51834505 |
| 38 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.51628537 |
| 39 | respiratory chain complex IV assembly (GO:0008535) | 3.51521354 |
| 40 | viral transcription (GO:0019083) | 3.50407202 |
| 41 | nerve growth factor signaling pathway (GO:0038180) | 3.48975059 |
| 42 | hydrogen ion transmembrane transport (GO:1902600) | 3.47565152 |
| 43 | protein targeting to ER (GO:0045047) | 3.45771508 |
| 44 | spliceosomal complex assembly (GO:0000245) | 3.45292392 |
| 45 | protein localization to endoplasmic reticulum (GO:0070972) | 3.32525787 |
| 46 | maturation of SSU-rRNA (GO:0030490) | 3.31397114 |
| 47 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.30547100 |
| 48 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.28992566 |
| 49 | mRNA transcription from RNA polymerase II promoter (GO:0042789) | 3.28847229 |
| 50 | fucose catabolic process (GO:0019317) | 3.28562739 |
| 51 | L-fucose metabolic process (GO:0042354) | 3.28562739 |
| 52 | L-fucose catabolic process (GO:0042355) | 3.28562739 |
| 53 | cytochrome complex assembly (GO:0017004) | 3.26055880 |
| 54 | cullin deneddylation (GO:0010388) | 3.25626041 |
| 55 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.25547394 |
| 56 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.24112165 |
| 57 | ribonucleoprotein complex disassembly (GO:0032988) | 3.23871346 |
| 58 | regulation of mitochondrial translation (GO:0070129) | 3.22296893 |
| 59 | response to testosterone (GO:0033574) | 3.19302677 |
| 60 | behavioral response to nicotine (GO:0035095) | 3.16727457 |
| 61 | renal system process involved in regulation of blood volume (GO:0001977) | 3.16614816 |
| 62 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.10847878 |
| 63 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.10550604 |
| 64 | regulation of renal sodium excretion (GO:0035813) | 3.09503259 |
| 65 | nucleoside diphosphate catabolic process (GO:0009134) | 3.08028065 |
| 66 | termination of RNA polymerase III transcription (GO:0006386) | 3.05676371 |
| 67 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.05676371 |
| 68 | response to pheromone (GO:0019236) | 3.04431207 |
| 69 | proton transport (GO:0015992) | 3.03114886 |
| 70 | DNA double-strand break processing (GO:0000729) | 3.02733684 |
| 71 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.02414168 |
| 72 | regulation of urine volume (GO:0035809) | 3.02208038 |
| 73 | regulation of helicase activity (GO:0051095) | 3.01563455 |
| 74 | circadian sleep/wake cycle process (GO:0022410) | 3.01159293 |
| 75 | regulation of excretion (GO:0044062) | 2.99078773 |
| 76 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.99067873 |
| 77 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.97375924 |
| 78 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 2.96616295 |
| 79 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 2.96616295 |
| 80 | hydrogen transport (GO:0006818) | 2.96584027 |
| 81 | positive regulation of erythrocyte differentiation (GO:0045648) | 2.96400073 |
| 82 | mitochondrial DNA replication (GO:0006264) | 2.95767727 |
| 83 | positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949) | 2.95167937 |
| 84 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.93554394 |
| 85 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.93554394 |
| 86 | protein deneddylation (GO:0000338) | 2.93383850 |
| 87 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.92431283 |
| 88 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.92154131 |
| 89 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.92154131 |
| 90 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.92154131 |
| 91 | ribosomal large subunit biogenesis (GO:0042273) | 2.90650289 |
| 92 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.89786631 |
| 93 | translational elongation (GO:0006414) | 2.88562803 |
| 94 | translation (GO:0006412) | 2.87331284 |
| 95 | positive regulation of heart rate (GO:0010460) | 2.87255405 |
| 96 | regulation of protein sumoylation (GO:0033233) | 2.87027352 |
| 97 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.86895171 |
| 98 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.85252841 |
| 99 | negative regulation of ligase activity (GO:0051352) | 2.85252841 |
| 100 | termination of RNA polymerase II transcription (GO:0006369) | 2.83944539 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.68758196 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.38380721 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.14186208 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.99916029 |
| 5 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.77368694 |
| 6 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 3.76599377 |
| 7 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.20619869 |
| 8 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 3.17056312 |
| 9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.98659943 |
| 10 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.96859175 |
| 11 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.95355078 |
| 12 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.85623413 |
| 13 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.76885815 |
| 14 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.76766784 |
| 15 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.72423119 |
| 16 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.70138946 |
| 17 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 2.61905170 |
| 18 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.53680468 |
| 19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.53566939 |
| 20 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.46497803 |
| 21 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.39688062 |
| 22 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.23922944 |
| 23 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.12445654 |
| 24 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 2.04079897 |
| 25 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 2.00114150 |
| 26 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.94707650 |
| 27 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.87298984 |
| 28 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.86895779 |
| 29 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.86203536 |
| 30 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.80125658 |
| 31 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.78442153 |
| 32 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.70957583 |
| 33 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.67597350 |
| 34 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.65872033 |
| 35 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.63187462 |
| 36 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.61112237 |
| 37 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.58238343 |
| 38 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.55882671 |
| 39 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.52587417 |
| 40 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.52263203 |
| 41 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.51609395 |
| 42 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.48275798 |
| 43 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.44456508 |
| 44 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.42141011 |
| 45 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.41705943 |
| 46 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.40275423 |
| 47 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.40180005 |
| 48 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.35705267 |
| 49 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.30803324 |
| 50 | EWS_26573619_Chip-Seq_HEK293_Human | 1.25669846 |
| 51 | VDR_22108803_ChIP-Seq_LS180_Human | 1.24582871 |
| 52 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.24390259 |
| 53 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.24116209 |
| 54 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.23754147 |
| 55 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.21807086 |
| 56 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.20353624 |
| 57 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.20284152 |
| 58 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.19604894 |
| 59 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.18565260 |
| 60 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.18431747 |
| 61 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.17289628 |
| 62 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.14309047 |
| 63 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.13947488 |
| 64 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.13937071 |
| 65 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.12518759 |
| 66 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.09517766 |
| 67 | FUS_26573619_Chip-Seq_HEK293_Human | 1.08923072 |
| 68 | AR_20517297_ChIP-Seq_VCAP_Human | 1.03656200 |
| 69 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.03264847 |
| 70 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.03085142 |
| 71 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.00770709 |
| 72 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.00644209 |
| 73 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.00470857 |
| 74 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.97656881 |
| 75 | GATA3_26560356_Chip-Seq_TH2_Human | 0.96502214 |
| 76 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.95846711 |
| 77 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.95846711 |
| 78 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.95072870 |
| 79 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.94778119 |
| 80 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.93720644 |
| 81 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.93683624 |
| 82 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.92025555 |
| 83 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.92025555 |
| 84 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.91963331 |
| 85 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.91552898 |
| 86 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.90849200 |
| 87 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.87510698 |
| 88 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.86603181 |
| 89 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.85568909 |
| 90 | P300_19829295_ChIP-Seq_ESCs_Human | 0.85052876 |
| 91 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.83931022 |
| 92 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.82619290 |
| 93 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.81778202 |
| 94 | SOX9_26525672_Chip-Seq_Limbbuds_Mouse | 0.81185817 |
| 95 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.80084340 |
| 96 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.78634400 |
| 97 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.77737581 |
| 98 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.77698083 |
| 99 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.77532747 |
| 100 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.76477526 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0000372_irregular_coat_pigmentation | 5.16294341 |
| 2 | MP0005499_abnormal_olfactory_system | 3.02107614 |
| 3 | MP0005394_taste/olfaction_phenotype | 3.02107614 |
| 4 | MP0008789_abnormal_olfactory_epithelium | 2.94075045 |
| 5 | MP0002234_abnormal_pharynx_morphology | 2.93921298 |
| 6 | MP0002102_abnormal_ear_morphology | 2.82433822 |
| 7 | MP0005075_abnormal_melanosome_morpholog | 2.76390046 |
| 8 | MP0002822_catalepsy | 2.50160750 |
| 9 | MP0006292_abnormal_olfactory_placode | 2.46269158 |
| 10 | MP0001529_abnormal_vocalization | 2.45063987 |
| 11 | MP0005408_hypopigmentation | 2.38989388 |
| 12 | MP0009379_abnormal_foot_pigmentation | 2.30711674 |
| 13 | MP0001984_abnormal_olfaction | 2.24248168 |
| 14 | MP0006036_abnormal_mitochondrial_physio | 2.18933325 |
| 15 | MP0004270_analgesia | 2.17877986 |
| 16 | MP0006035_abnormal_mitochondrial_morpho | 2.08006159 |
| 17 | MP0008995_early_reproductive_senescence | 2.03017622 |
| 18 | MP0001881_abnormal_mammary_gland | 2.00709205 |
| 19 | MP0002163_abnormal_gland_morphology | 1.96887543 |
| 20 | MP0006276_abnormal_autonomic_nervous | 1.93346492 |
| 21 | MP0002796_impaired_skin_barrier | 1.84300019 |
| 22 | MP0003693_abnormal_embryo_hatching | 1.80709107 |
| 23 | MP0000749_muscle_degeneration | 1.76874289 |
| 24 | MP0004142_abnormal_muscle_tone | 1.70450140 |
| 25 | MP0008058_abnormal_DNA_repair | 1.63723038 |
| 26 | MP0003786_premature_aging | 1.63050429 |
| 27 | MP0003186_abnormal_redox_activity | 1.62141974 |
| 28 | MP0001790_abnormal_immune_system | 1.60877155 |
| 29 | MP0005387_immune_system_phenotype | 1.60877155 |
| 30 | MP0004381_abnormal_hair_follicle | 1.57464016 |
| 31 | MP0002938_white_spotting | 1.49509748 |
| 32 | MP0005646_abnormal_pituitary_gland | 1.48424988 |
| 33 | MP0003011_delayed_dark_adaptation | 1.46304911 |
| 34 | MP0002090_abnormal_vision | 1.46105867 |
| 35 | MP0005084_abnormal_gallbladder_morpholo | 1.45189540 |
| 36 | MP0004145_abnormal_muscle_electrophysio | 1.43987334 |
| 37 | MP0003195_calcinosis | 1.41803541 |
| 38 | MP0002138_abnormal_hepatobiliary_system | 1.41752138 |
| 39 | MP0002751_abnormal_autonomic_nervous | 1.41148779 |
| 40 | MP0006072_abnormal_retinal_apoptosis | 1.36403306 |
| 41 | MP0000627_abnormal_mammary_gland | 1.36362791 |
| 42 | MP0008877_abnormal_DNA_methylation | 1.33701035 |
| 43 | MP0001286_abnormal_eye_development | 1.33559152 |
| 44 | MP0001905_abnormal_dopamine_level | 1.30195453 |
| 45 | MP0005551_abnormal_eye_electrophysiolog | 1.29302095 |
| 46 | MP0001919_abnormal_reproductive_system | 1.26807253 |
| 47 | MP0000631_abnormal_neuroendocrine_gland | 1.21598236 |
| 48 | MP0005253_abnormal_eye_physiology | 1.20378681 |
| 49 | MP0002697_abnormal_eye_size | 1.17843826 |
| 50 | MP0002653_abnormal_ependyma_morphology | 1.17038901 |
| 51 | MP0002837_dystrophic_cardiac_calcinosis | 1.15823531 |
| 52 | MP0001188_hyperpigmentation | 1.14518828 |
| 53 | MP0001485_abnormal_pinna_reflex | 1.12375355 |
| 54 | MP0005501_abnormal_skin_physiology | 1.09226921 |
| 55 | MP0002735_abnormal_chemical_nociception | 1.08945807 |
| 56 | MP0010094_abnormal_chromosome_stability | 1.08933668 |
| 57 | MP0005379_endocrine/exocrine_gland_phen | 1.08711293 |
| 58 | MP0002277_abnormal_respiratory_mucosa | 1.07934551 |
| 59 | MP0000358_abnormal_cell_content/ | 1.04783140 |
| 60 | MP0009745_abnormal_behavioral_response | 1.04348496 |
| 61 | MP0005389_reproductive_system_phenotype | 1.03646520 |
| 62 | MP0005410_abnormal_fertilization | 1.01792460 |
| 63 | MP0000516_abnormal_urinary_system | 0.97320011 |
| 64 | MP0005367_renal/urinary_system_phenotyp | 0.97320011 |
| 65 | MP0003718_maternal_effect | 0.95703085 |
| 66 | MP0000653_abnormal_sex_gland | 0.94671597 |
| 67 | MP0001486_abnormal_startle_reflex | 0.94532141 |
| 68 | MP0003936_abnormal_reproductive_system | 0.94393870 |
| 69 | MP0010368_abnormal_lymphatic_system | 0.92440637 |
| 70 | MP0010386_abnormal_urinary_bladder | 0.91590651 |
| 71 | MP0003828_pulmonary_edema | 0.91382867 |
| 72 | MP0001929_abnormal_gametogenesis | 0.91082259 |
| 73 | MP0003303_peritoneal_inflammation | 0.90274400 |
| 74 | MP0002734_abnormal_mechanical_nocicepti | 0.87801620 |
| 75 | MP0005332_abnormal_amino_acid | 0.86875316 |
| 76 | MP0001853_heart_inflammation | 0.84265790 |
| 77 | MP0005195_abnormal_posterior_eye | 0.82117131 |
| 78 | MP0005391_vision/eye_phenotype | 0.80411131 |
| 79 | MP0001293_anophthalmia | 0.80124290 |
| 80 | MP0004742_abnormal_vestibular_system | 0.79027428 |
| 81 | MP0001963_abnormal_hearing_physiology | 0.77719922 |
| 82 | MP0004215_abnormal_myocardial_fiber | 0.77363333 |
| 83 | MP0003880_abnormal_central_pattern | 0.77362499 |
| 84 | MP0002272_abnormal_nervous_system | 0.75873651 |
| 85 | MP0002210_abnormal_sex_determination | 0.75752536 |
| 86 | MP0004885_abnormal_endolymph | 0.74828998 |
| 87 | MP0000015_abnormal_ear_pigmentation | 0.72957404 |
| 88 | MP0002752_abnormal_somatic_nervous | 0.70517852 |
| 89 | MP0002160_abnormal_reproductive_system | 0.69478094 |
| 90 | MP0005360_urolithiasis | 0.69442860 |
| 91 | MP0004510_myositis | 0.68936554 |
| 92 | MP0004957_abnormal_blastocyst_morpholog | 0.68669114 |
| 93 | MP0001764_abnormal_homeostasis | 0.66606838 |
| 94 | MP0002132_abnormal_respiratory_system | 0.65916699 |
| 95 | MP0001800_abnormal_humoral_immune | 0.65785574 |
| 96 | MP0001119_abnormal_female_reproductive | 0.65652417 |
| 97 | MP0009046_muscle_twitch | 0.65440435 |
| 98 | MP0004133_heterotaxia | 0.64761236 |
| 99 | MP0008961_abnormal_basal_metabolism | 0.60781300 |
| 100 | MP0002909_abnormal_adrenal_gland | 0.59948849 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | 3-Methylglutaconic aciduria (HP:0003535) | 5.82755728 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 5.82300031 |
| 3 | Acute encephalopathy (HP:0006846) | 5.60478781 |
| 4 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.00020051 |
| 5 | Abnormality of the labia minora (HP:0012880) | 4.98550464 |
| 6 | Mitochondrial inheritance (HP:0001427) | 4.86685369 |
| 7 | Progressive macrocephaly (HP:0004481) | 4.83928282 |
| 8 | Increased CSF lactate (HP:0002490) | 4.38563312 |
| 9 | Increased hepatocellular lipid droplets (HP:0006565) | 4.05897934 |
| 10 | Lipid accumulation in hepatocytes (HP:0006561) | 3.96067827 |
| 11 | Hepatocellular necrosis (HP:0001404) | 3.94222290 |
| 12 | Cerebral edema (HP:0002181) | 3.69548191 |
| 13 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.54701979 |
| 14 | Renal Fanconi syndrome (HP:0001994) | 3.44264016 |
| 15 | Hepatic necrosis (HP:0002605) | 3.31042652 |
| 16 | Oligodactyly (hands) (HP:0001180) | 3.17138932 |
| 17 | Meckel diverticulum (HP:0002245) | 3.13403438 |
| 18 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.10690137 |
| 19 | Molar tooth sign on MRI (HP:0002419) | 3.00602279 |
| 20 | Abnormality of midbrain morphology (HP:0002418) | 3.00602279 |
| 21 | Optic disc pallor (HP:0000543) | 2.98746976 |
| 22 | Medial flaring of the eyebrow (HP:0010747) | 2.97602756 |
| 23 | Short tibia (HP:0005736) | 2.97518176 |
| 24 | Leukodystrophy (HP:0002415) | 2.94425714 |
| 25 | Abnormality of the ileum (HP:0001549) | 2.84374843 |
| 26 | Bifid tongue (HP:0010297) | 2.80310164 |
| 27 | Congenital, generalized hypertrichosis (HP:0004540) | 2.77131941 |
| 28 | Exercise intolerance (HP:0003546) | 2.74110336 |
| 29 | Reticulocytopenia (HP:0001896) | 2.74086430 |
| 30 | Congenital primary aphakia (HP:0007707) | 2.70394322 |
| 31 | Colon cancer (HP:0003003) | 2.69697528 |
| 32 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.68385222 |
| 33 | Exertional dyspnea (HP:0002875) | 2.64798745 |
| 34 | Respiratory failure (HP:0002878) | 2.60799251 |
| 35 | Gait imbalance (HP:0002141) | 2.58235883 |
| 36 | Nephrogenic diabetes insipidus (HP:0009806) | 2.58036310 |
| 37 | Respiratory difficulties (HP:0002880) | 2.56784629 |
| 38 | Ectopic kidney (HP:0000086) | 2.53618154 |
| 39 | Lactic acidosis (HP:0003128) | 2.47706456 |
| 40 | Increased serum lactate (HP:0002151) | 2.46231319 |
| 41 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.44751417 |
| 42 | Oligodactyly (HP:0012165) | 2.43417990 |
| 43 | Dyschromatopsia (HP:0007641) | 2.40937069 |
| 44 | Abnormal number of erythroid precursors (HP:0012131) | 2.40783910 |
| 45 | Poor coordination (HP:0002370) | 2.35526279 |
| 46 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.32730397 |
| 47 | Chorioretinal atrophy (HP:0000533) | 2.31404697 |
| 48 | Testicular atrophy (HP:0000029) | 2.30172339 |
| 49 | Horseshoe kidney (HP:0000085) | 2.28591827 |
| 50 | Abnormality of the preputium (HP:0100587) | 2.28358670 |
| 51 | Clubbing of toes (HP:0100760) | 2.27964647 |
| 52 | Hypoplastic labia majora (HP:0000059) | 2.27672533 |
| 53 | Recurrent corneal erosions (HP:0000495) | 2.21872343 |
| 54 | Supernumerary spleens (HP:0009799) | 2.19087268 |
| 55 | Hyperphosphaturia (HP:0003109) | 2.18688244 |
| 56 | Increased intramyocellular lipid droplets (HP:0012240) | 2.17440683 |
| 57 | Genital tract atresia (HP:0001827) | 2.13352442 |
| 58 | Abnormality of the labia (HP:0000058) | 2.12860563 |
| 59 | Lethargy (HP:0001254) | 2.12398634 |
| 60 | Microvesicular hepatic steatosis (HP:0001414) | 2.10800186 |
| 61 | Emotional lability (HP:0000712) | 2.10309519 |
| 62 | Hyperglycinemia (HP:0002154) | 2.05743192 |
| 63 | Small intestinal stenosis (HP:0012848) | 2.04090300 |
| 64 | Duodenal stenosis (HP:0100867) | 2.04090300 |
| 65 | Sensory axonal neuropathy (HP:0003390) | 2.03981571 |
| 66 | Abnormality of the labia majora (HP:0012881) | 2.03722171 |
| 67 | Amniotic constriction ring (HP:0009775) | 2.02910776 |
| 68 | Abnormality of placental membranes (HP:0011409) | 2.02910776 |
| 69 | Astigmatism (HP:0000483) | 2.02887958 |
| 70 | Pancreatic cysts (HP:0001737) | 2.02178222 |
| 71 | Absent thumb (HP:0009777) | 2.00683110 |
| 72 | Arthropathy (HP:0003040) | 1.99334304 |
| 73 | Parakeratosis (HP:0001036) | 1.98404469 |
| 74 | Abnormality of chromosome stability (HP:0003220) | 1.97546686 |
| 75 | Abnormality of renal resorption (HP:0011038) | 1.96771128 |
| 76 | Vaginal atresia (HP:0000148) | 1.95457747 |
| 77 | Autoamputation (HP:0001218) | 1.94390395 |
| 78 | Macrocytic anemia (HP:0001972) | 1.94102511 |
| 79 | Abnormality of urine glucose concentration (HP:0011016) | 1.93980499 |
| 80 | Glycosuria (HP:0003076) | 1.93980499 |
| 81 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.93769487 |
| 82 | Abnormality of alanine metabolism (HP:0010916) | 1.93769487 |
| 83 | Hyperalaninemia (HP:0003348) | 1.93769487 |
| 84 | X-linked dominant inheritance (HP:0001423) | 1.92580470 |
| 85 | Tubular atrophy (HP:0000092) | 1.91284593 |
| 86 | Median cleft lip (HP:0000161) | 1.88228848 |
| 87 | Gout (HP:0001997) | 1.87841245 |
| 88 | Abnormal urine phosphate concentration (HP:0012599) | 1.87642918 |
| 89 | Increased muscle lipid content (HP:0009058) | 1.87582310 |
| 90 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.84015991 |
| 91 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.82809102 |
| 92 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.81915676 |
| 93 | Abnormal biliary tract physiology (HP:0012439) | 1.77852318 |
| 94 | Bile duct proliferation (HP:0001408) | 1.77852318 |
| 95 | Type II lissencephaly (HP:0007260) | 1.76338103 |
| 96 | Anhidrosis (HP:0000970) | 1.76068484 |
| 97 | Abnormality of the anterior horn cell (HP:0006802) | 1.73957414 |
| 98 | Degeneration of anterior horn cells (HP:0002398) | 1.73957414 |
| 99 | Blindness (HP:0000618) | 1.73322450 |
| 100 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.72615255 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK1 | 4.17573161 |
| 2 | TAOK1 | 3.49485219 |
| 3 | MATK | 3.45386069 |
| 4 | VRK2 | 3.31400684 |
| 5 | MAPKAPK3 | 3.17584119 |
| 6 | TAOK2 | 3.13825365 |
| 7 | NUAK1 | 2.84193128 |
| 8 | EIF2AK3 | 2.81075758 |
| 9 | FES | 2.79495536 |
| 10 | EIF2AK1 | 2.61354127 |
| 11 | MAP3K11 | 2.32279522 |
| 12 | MAP4K2 | 2.11063907 |
| 13 | STK16 | 1.98981302 |
| 14 | NME1 | 1.88644111 |
| 15 | DAPK1 | 1.83890050 |
| 16 | EPHA4 | 1.70543596 |
| 17 | NLK | 1.68193229 |
| 18 | MAP3K3 | 1.65166557 |
| 19 | DYRK3 | 1.62247466 |
| 20 | TAOK3 | 1.55673409 |
| 21 | MST4 | 1.48784603 |
| 22 | VRK1 | 1.47875463 |
| 23 | TRIM28 | 1.45494955 |
| 24 | MAP3K10 | 1.45035879 |
| 25 | MAP3K12 | 1.44272266 |
| 26 | GRK1 | 1.41583565 |
| 27 | CSNK1G3 | 1.40187356 |
| 28 | PHKG1 | 1.35921746 |
| 29 | PHKG2 | 1.35921746 |
| 30 | PASK | 1.33847225 |
| 31 | CSNK1G2 | 1.31673593 |
| 32 | PIK3CG | 1.20875944 |
| 33 | MAP3K5 | 1.18954725 |
| 34 | BUB1 | 1.18054301 |
| 35 | TSSK6 | 1.17088466 |
| 36 | CSNK1A1L | 1.16941226 |
| 37 | WNK3 | 1.14884206 |
| 38 | CCNB1 | 1.13680098 |
| 39 | CSNK1G1 | 1.10965688 |
| 40 | ADRBK2 | 1.04904517 |
| 41 | TLK1 | 1.03927103 |
| 42 | SRPK1 | 0.96955479 |
| 43 | ZAK | 0.91323614 |
| 44 | CHEK2 | 0.90346375 |
| 45 | CDK3 | 0.87788951 |
| 46 | CSK | 0.85413559 |
| 47 | ERBB2 | 0.84796131 |
| 48 | LATS2 | 0.80424476 |
| 49 | DYRK2 | 0.77801956 |
| 50 | BCKDK | 0.76986502 |
| 51 | ATR | 0.76844970 |
| 52 | PLK3 | 0.76204873 |
| 53 | SIK3 | 0.74875789 |
| 54 | MKNK2 | 0.74738769 |
| 55 | MAP2K3 | 0.73701009 |
| 56 | NME2 | 0.72421034 |
| 57 | ALK | 0.72066178 |
| 58 | INSRR | 0.69852768 |
| 59 | DAPK3 | 0.67972688 |
| 60 | MYLK | 0.67888024 |
| 61 | FER | 0.66232311 |
| 62 | CASK | 0.62997648 |
| 63 | MAP3K4 | 0.59942806 |
| 64 | PINK1 | 0.57996621 |
| 65 | BCR | 0.56131353 |
| 66 | CSNK2A1 | 0.56086573 |
| 67 | PDK2 | 0.55332390 |
| 68 | GRK7 | 0.52410564 |
| 69 | FRK | 0.50506467 |
| 70 | GRK5 | 0.46699557 |
| 71 | MKNK1 | 0.46570273 |
| 72 | ILK | 0.45894371 |
| 73 | OBSCN | 0.43805027 |
| 74 | MAP2K7 | 0.42853966 |
| 75 | EIF2AK2 | 0.42282714 |
| 76 | WEE1 | 0.41776625 |
| 77 | PIK3CA | 0.40505315 |
| 78 | AURKA | 0.37639405 |
| 79 | TYRO3 | 0.37608617 |
| 80 | CSNK2A2 | 0.37586015 |
| 81 | CAMK2D | 0.37224755 |
| 82 | PLK2 | 0.37066569 |
| 83 | CSNK1E | 0.36827707 |
| 84 | TIE1 | 0.35849958 |
| 85 | MARK3 | 0.35745728 |
| 86 | MAPK13 | 0.32551236 |
| 87 | IRAK2 | 0.30213058 |
| 88 | CAMK2G | 0.30158068 |
| 89 | OXSR1 | 0.29957715 |
| 90 | PLK1 | 0.28549709 |
| 91 | PAK4 | 0.28331932 |
| 92 | AURKB | 0.26760277 |
| 93 | PBK | 0.26587111 |
| 94 | PRKCI | 0.25784877 |
| 95 | NEK9 | 0.25618687 |
| 96 | MAPKAPK5 | 0.24479778 |
| 97 | PKN1 | 0.24180637 |
| 98 | NEK1 | 0.24098695 |
| 99 | RPS6KA4 | 0.23824955 |
| 100 | INSR | 0.23674832 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.68090144 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.25954962 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 4.06244870 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 3.98770697 |
| 5 | Protein export_Homo sapiens_hsa03060 | 3.22026901 |
| 6 | Huntingtons disease_Homo sapiens_hsa05016 | 2.80902861 |
| 7 | Alzheimers disease_Homo sapiens_hsa05010 | 2.63201015 |
| 8 | Mismatch repair_Homo sapiens_hsa03430 | 2.56331488 |
| 9 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.39905396 |
| 10 | RNA polymerase_Homo sapiens_hsa03020 | 2.35872410 |
| 11 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.27397622 |
| 12 | DNA replication_Homo sapiens_hsa03030 | 2.05656713 |
| 13 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.03828276 |
| 14 | Spliceosome_Homo sapiens_hsa03040 | 1.99013021 |
| 15 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.91253188 |
| 16 | Homologous recombination_Homo sapiens_hsa03440 | 1.90980276 |
| 17 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.88184739 |
| 18 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.67969644 |
| 19 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.60868959 |
| 20 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.59792669 |
| 21 | Base excision repair_Homo sapiens_hsa03410 | 1.58949391 |
| 22 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.54206980 |
| 23 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.46951218 |
| 24 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.32554448 |
| 25 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.32372272 |
| 26 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.29574884 |
| 27 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.28497196 |
| 28 | Purine metabolism_Homo sapiens_hsa00230 | 1.24217541 |
| 29 | RNA degradation_Homo sapiens_hsa03018 | 1.23833204 |
| 30 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.20499750 |
| 31 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.20443024 |
| 32 | Allograft rejection_Homo sapiens_hsa05330 | 1.15550670 |
| 33 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.14413362 |
| 34 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.10613262 |
| 35 | RNA transport_Homo sapiens_hsa03013 | 1.08483145 |
| 36 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.06569902 |
| 37 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.04345074 |
| 38 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.02967992 |
| 39 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.02574280 |
| 40 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.98813609 |
| 41 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.95952796 |
| 42 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.95699053 |
| 43 | Basal transcription factors_Homo sapiens_hsa03022 | 0.93486012 |
| 44 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.93300481 |
| 45 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.87027550 |
| 46 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.86513930 |
| 47 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.84971046 |
| 48 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.83592877 |
| 49 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.81318998 |
| 50 | Peroxisome_Homo sapiens_hsa04146 | 0.80235766 |
| 51 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.79811454 |
| 52 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.79009528 |
| 53 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.77963904 |
| 54 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.70551809 |
| 55 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.69694761 |
| 56 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.68743972 |
| 57 | Metabolic pathways_Homo sapiens_hsa01100 | 0.68136809 |
| 58 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.66600479 |
| 59 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.65147530 |
| 60 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.64318923 |
| 61 | Carbon metabolism_Homo sapiens_hsa01200 | 0.60968258 |
| 62 | Asthma_Homo sapiens_hsa05310 | 0.59834545 |
| 63 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.58891202 |
| 64 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.56055524 |
| 65 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.55544753 |
| 66 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.54619179 |
| 67 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.52987588 |
| 68 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.51830866 |
| 69 | Mineral absorption_Homo sapiens_hsa04978 | 0.51191892 |
| 70 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.47795858 |
| 71 | Phototransduction_Homo sapiens_hsa04744 | 0.46256310 |
| 72 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.42487003 |
| 73 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.41076198 |
| 74 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.40585110 |
| 75 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.40531988 |
| 76 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.39141886 |
| 77 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.39083250 |
| 78 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.38903430 |
| 79 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.38675282 |
| 80 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.38022013 |
| 81 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.37486190 |
| 82 | Thyroid cancer_Homo sapiens_hsa05216 | 0.36453789 |
| 83 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.36016005 |
| 84 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.34604812 |
| 85 | Cell cycle_Homo sapiens_hsa04110 | 0.34113330 |
| 86 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.33311491 |
| 87 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.32476586 |
| 88 | Retinol metabolism_Homo sapiens_hsa00830 | 0.32129524 |
| 89 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.30021820 |
| 90 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.26726098 |
| 91 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.25976071 |
| 92 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.25333754 |
| 93 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.23590109 |
| 94 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.23066813 |
| 95 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.23015203 |
| 96 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.22438508 |
| 97 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.21246630 |
| 98 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.20357262 |
| 99 | Olfactory transduction_Homo sapiens_hsa04740 | 0.17540704 |
| 100 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.17498662 |

