LYPLA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.70819653
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.70819653
3antigen processing and presentation of endogenous antigen (GO:0019883)4.97083864
4protein maturation by protein folding (GO:0022417)4.80187351
5Arp2/3 complex-mediated actin nucleation (GO:0034314)4.34554694
6Golgi transport vesicle coating (GO:0048200)4.27038896
7COPI coating of Golgi vesicle (GO:0048205)4.27038896
8histone arginine methylation (GO:0034969)4.24617342
9DNA deamination (GO:0045006)4.22494879
10GDP-mannose metabolic process (GO:0019673)4.04940866
11establishment of integrated proviral latency (GO:0075713)4.03442837
12pentose-phosphate shunt (GO:0006098)3.92872879
13establishment of viral latency (GO:0019043)3.78398605
14maternal placenta development (GO:0001893)3.78379766
15regulation of gamma-delta T cell differentiation (GO:0045586)3.76181108
16negative regulation of cell size (GO:0045792)3.75200448
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.64252793
18proline biosynthetic process (GO:0006561)3.63043546
19positive regulation of gamma-delta T cell activation (GO:0046645)3.59290629
20antigen processing and presentation via MHC class Ib (GO:0002475)3.54954057
21pentose metabolic process (GO:0019321)3.54092810
22folic acid-containing compound biosynthetic process (GO:0009396)3.47182026
23negative regulation of ligase activity (GO:0051352)3.42617219
24negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.42617219
25regulation of cholesterol homeostasis (GO:2000188)3.37579722
26NADPH regeneration (GO:0006740)3.36199058
27positive regulation of lamellipodium assembly (GO:0010592)3.34158815
28pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.30113013
29L-serine metabolic process (GO:0006563)3.25323936
30regulation of cellular amino acid metabolic process (GO:0006521)3.24530703
31peptidyl-arginine methylation (GO:0018216)3.23484678
32peptidyl-arginine N-methylation (GO:0035246)3.23484678
33regulation of gamma-delta T cell activation (GO:0046643)3.22915773
34regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.22118792
35base-excision repair, AP site formation (GO:0006285)3.20335826
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.17811673
37cellular response to interleukin-4 (GO:0071353)3.16665429
38negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.16110375
39positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.15042491
40proteasome assembly (GO:0043248)3.14914082
41positive thymic T cell selection (GO:0045059)3.13146202
42protein retention in ER lumen (GO:0006621)3.12856273
43barbed-end actin filament capping (GO:0051016)3.10693583
44ribosomal small subunit biogenesis (GO:0042274)3.07427727
45positive regulation of histone deacetylation (GO:0031065)3.06711728
46nuclear envelope reassembly (GO:0031468)3.06444010
47mitotic nuclear envelope reassembly (GO:0007084)3.06444010
48DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.04759382
49regulation of translational fidelity (GO:0006450)3.02027906
50antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.98508356
51negative regulation of erythrocyte differentiation (GO:0045647)2.98361380
52signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.97228140
53intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.97228140
54regulation of protein heterodimerization activity (GO:0043497)2.97141391
55positive regulation of lamellipodium organization (GO:1902745)2.96773800
56maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.96640413
57DNA unwinding involved in DNA replication (GO:0006268)2.95776668
58anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.95651496
59deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.94704849
60signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.93999589
61signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.93999589
62signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.93999589
63regulation of mitochondrial translation (GO:0070129)2.93490650
64actin nucleation (GO:0045010)2.92941579
65protein targeting to mitochondrion (GO:0006626)2.91695515
66signal transduction involved in DNA integrity checkpoint (GO:0072401)2.91546494
67signal transduction involved in DNA damage checkpoint (GO:0072422)2.91546494
68regulation of early endosome to late endosome transport (GO:2000641)2.90032058
69regulation of defense response to virus by virus (GO:0050690)2.89957617
70L-phenylalanine metabolic process (GO:0006558)2.88958866
71erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.88958866
72tricarboxylic acid metabolic process (GO:0072350)2.85197191
73signal transduction involved in cell cycle checkpoint (GO:0072395)2.85021517
74activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.84855430
75lysine metabolic process (GO:0006553)2.84097360
76lysine catabolic process (GO:0006554)2.84097360
77sulfur amino acid catabolic process (GO:0000098)2.83513399
78sequestering of actin monomers (GO:0042989)2.83016144
79pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.82636057
80formation of translation preinitiation complex (GO:0001731)2.82244884
81oxidative phosphorylation (GO:0006119)2.82227656
82alpha-linolenic acid metabolic process (GO:0036109)2.81478822
83negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.81055588
84deoxyribonucleotide catabolic process (GO:0009264)2.79742489
85negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.79399511
86response to interleukin-4 (GO:0070670)2.78648429
87ribosomal small subunit assembly (GO:0000028)2.77427097
88pyrimidine nucleotide catabolic process (GO:0006244)2.76485128
89regulation of type I interferon-mediated signaling pathway (GO:0060338)2.76230569
90positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.76090392
91positive regulation of nuclease activity (GO:0032075)2.75649872
92establishment of protein localization to mitochondrion (GO:0072655)2.74845441
93negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.74748680
94negative regulation of cell killing (GO:0031342)2.74748680
95thymic T cell selection (GO:0045061)2.74418210
96positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.74206215
97activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.73822715
98guanosine-containing compound biosynthetic process (GO:1901070)2.73770259
99pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.73722960
100oxaloacetate metabolic process (GO:0006107)2.72920223
101pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.72632270
102NADH metabolic process (GO:0006734)2.72582309
103pteridine-containing compound biosynthetic process (GO:0042559)2.72007483
104pinocytosis (GO:0006907)2.71420383
105regulation of translational termination (GO:0006449)2.70666298
106glucose 6-phosphate metabolic process (GO:0051156)2.70555614
107T cell apoptotic process (GO:0070231)2.70506496
108iron-sulfur cluster assembly (GO:0016226)2.69680286
109metallo-sulfur cluster assembly (GO:0031163)2.69680286
110ribosome assembly (GO:0042255)2.69567889
111positive regulation of protein deacetylation (GO:0090312)2.69201215
112L-alpha-amino acid transmembrane transport (GO:1902475)2.69193176
113negative thymic T cell selection (GO:0045060)2.69010102
114positive regulation of ligase activity (GO:0051351)2.68550787
115regulation of mammary gland epithelial cell proliferation (GO:0033599)2.67973396
116amyloid precursor protein catabolic process (GO:0042987)2.67218390
117nucleotide salvage (GO:0043173)2.66665170
118deoxyribose phosphate catabolic process (GO:0046386)2.65918791
119positive regulation of triglyceride biosynthetic process (GO:0010867)2.65770824
120mitotic G1 DNA damage checkpoint (GO:0031571)2.65502743
121endothelial tube morphogenesis (GO:0061154)2.65475984
122morphogenesis of an endothelium (GO:0003159)2.65475984
123nucleobase-containing small molecule interconversion (GO:0015949)2.65269156
124positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.65211339
125regulation of ubiquitin-protein transferase activity (GO:0051438)2.63963734
126chaperone-mediated protein transport (GO:0072321)2.63901535
127virion assembly (GO:0019068)2.63035119
128regulation of superoxide anion generation (GO:0032928)2.61743956
129NADP metabolic process (GO:0006739)2.60506793
130negative T cell selection (GO:0043383)2.59391758
131mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.58808608
132regulation of ligase activity (GO:0051340)2.58118213
133negative regulation of sterol transport (GO:0032372)2.57731490
134negative regulation of cholesterol transport (GO:0032375)2.57731490
135DNA damage response, detection of DNA damage (GO:0042769)2.57600885
136CTP metabolic process (GO:0046036)2.56804099
137CTP biosynthetic process (GO:0006241)2.56804099
138glycine metabolic process (GO:0006544)2.56593254
139viral transcription (GO:0019083)2.55264784
140UTP biosynthetic process (GO:0006228)2.54845512
141protein insertion into membrane (GO:0051205)2.54140171
142monosaccharide biosynthetic process (GO:0046364)2.53977777
143retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.53150231
144pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.52878108
145regulation of nuclease activity (GO:0032069)2.52373485
146nucleoside salvage (GO:0043174)2.51683814
147ribosomal large subunit biogenesis (GO:0042273)2.51041511
148protein localization to mitochondrion (GO:0070585)2.50081128
149spliceosomal snRNP assembly (GO:0000387)2.49602916
150regulation of cellular amine metabolic process (GO:0033238)2.49395513
151translational elongation (GO:0006414)2.49203124
152glucose catabolic process (GO:0006007)2.48402240
153ribonucleoprotein complex biogenesis (GO:0022613)2.48264363
154regulation of response to interferon-gamma (GO:0060330)2.47615839
155purine deoxyribonucleotide catabolic process (GO:0009155)2.47363194
156regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.47268893
157negative regulation of RNA splicing (GO:0033119)2.47263011
158dosage compensation (GO:0007549)2.47225175
159purine nucleotide salvage (GO:0032261)2.46841638
1603-UTR-mediated mRNA stabilization (GO:0070935)2.46540505
161proline metabolic process (GO:0006560)2.44963114
162negative regulation of innate immune response (GO:0045824)2.44932680
163viral protein processing (GO:0019082)2.44545257
164negative regulation of DNA-templated transcription, elongation (GO:0032785)2.44306808
165folic acid metabolic process (GO:0046655)2.44160645
166peptidyl-arginine omega-N-methylation (GO:0035247)2.43938592
167intracellular estrogen receptor signaling pathway (GO:0030520)2.43703113
168lymphocyte apoptotic process (GO:0070227)2.40270422
169mitotic G1/S transition checkpoint (GO:0044819)2.39013785
170regulation of cholesterol storage (GO:0010885)2.35336531
171JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.33724833
172translational termination (GO:0006415)2.33515796
1734-hydroxyproline metabolic process (GO:0019471)2.33326387
174valine metabolic process (GO:0006573)2.32859665
175heterochromatin organization (GO:0070828)2.32062720
176response to interleukin-15 (GO:0070672)2.30800341
177endoplasmic reticulum unfolded protein response (GO:0030968)2.30705309
178pyrimidine-containing compound salvage (GO:0008655)2.27411956
179pyrimidine nucleoside salvage (GO:0043097)2.27411956

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.39695455
2MYC_22102868_ChIP-Seq_BL_Human3.29541320
3VDR_21846776_ChIP-Seq_THP-1_Human2.61401335
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.50270618
5E2F7_22180533_ChIP-Seq_HELA_Human2.50168523
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.16557525
7LXR_22292898_ChIP-Seq_THP-1_Human2.13673111
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.11376525
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.08833800
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03827487
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.98957647
12PPARA_22158963_ChIP-Seq_LIVER_Mouse1.91742660
13MYC_18555785_ChIP-Seq_MESCs_Mouse1.88337985
14* ELK3_25401928_ChIP-Seq_HUVEC_Human1.86625923
15TCF7_22412390_ChIP-Seq_EML_Mouse1.78243789
16CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77388924
17NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77057106
18* MAF_26560356_Chip-Seq_TH1_Human1.74508313
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74467174
20RXR_22158963_ChIP-Seq_LIVER_Mouse1.72614043
21SRY_22984422_ChIP-ChIP_TESTIS_Rat1.69734734
22* KDM2B_26808549_Chip-Seq_DND41_Human1.69538163
23* GABP_17652178_ChIP-ChIP_JURKAT_Human1.69345224
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.66059223
25* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66038561
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65544250
27* UTX_26944678_Chip-Seq_JUKART_Human1.65319898
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64140395
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61791188
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.60150916
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.60016561
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59670555
33DCP1A_22483619_ChIP-Seq_HELA_Human1.57830269
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.57423359
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.56643219
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56526010
37* XRN2_22483619_ChIP-Seq_HELA_Human1.54021173
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53913344
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53583566
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53420036
41CIITA_25753668_ChIP-Seq_RAJI_Human1.52300313
42* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50049271
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49530469
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49417644
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49342293
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.49120260
47ZNF263_19887448_ChIP-Seq_K562_Human1.47899357
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43931994
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43585338
50MAF_26560356_Chip-Seq_TH2_Human1.42593523
51ELF1_20517297_ChIP-Seq_JURKAT_Human1.41508654
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41446955
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41077366
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40959352
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40807051
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40015965
57RACK7_27058665_Chip-Seq_MCF-7_Human1.39495135
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38801754
59P68_20966046_ChIP-Seq_HELA_Human1.36642239
60VDR_24763502_ChIP-Seq_THP-1_Human1.34541415
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34212892
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33363400
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.33003412
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32514467
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31056546
66FOXM1_23109430_ChIP-Seq_U2OS_Human1.28712226
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27913966
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.27286584
69* BCL6_27268052_Chip-Seq_Bcells_Human1.27175433
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26613391
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.26283765
72STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23923576
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23920054
74TTF2_22483619_ChIP-Seq_HELA_Human1.22277774
75ETS1_20019798_ChIP-Seq_JURKAT_Human1.22162475
76* GABP_19822575_ChIP-Seq_HepG2_Human1.21814648
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20860191
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20126114
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19497793
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19178029
81MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19078931
82MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19007734
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18931254
84OCT4_18692474_ChIP-Seq_MEFs_Mouse1.18309275
85* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18207558
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17775082
87HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17610136
88* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17521149
89* BCOR_27268052_Chip-Seq_Bcells_Human1.17449172
90ATF3_27146783_Chip-Seq_COLON_Human1.16870526
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16574346
92JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16434213
93ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15061834
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14952379
95FOXP3_21729870_ChIP-Seq_TREG_Human1.14590889
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13493655
97SA1_27219007_Chip-Seq_ERYTHROID_Human1.13461385
98SRF_21415370_ChIP-Seq_HL-1_Mouse1.12739226
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11550748
100ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11168472
101PHF8_20622854_ChIP-Seq_HELA_Human1.11039867
102RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10873557
103HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10246086
104MYB_26560356_Chip-Seq_TH1_Human1.10233230
105CTCF_18555785_ChIP-Seq_MESCs_Mouse1.10193479
106CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09970889
107MYB_26560356_Chip-Seq_TH2_Human1.07287092
108YY1_22570637_ChIP-Seq_MALME-3M_Human1.06282349
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06042822
110ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05966836
111SCL_19346495_ChIP-Seq_HPC-7_Human1.05836457
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04610527
113KDM5A_27292631_Chip-Seq_BREAST_Human1.04203153
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04065935
115SPI1_23547873_ChIP-Seq_NB4_Human1.03367758
116* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03164549
117CTCF_21964334_Chip-Seq_Bcells_Human1.03031113
118* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.02307782
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02131296
120SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00884055
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00823119
122* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00822715
123EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00813481
124NCOR1_26117541_ChIP-Seq_K562_Human1.00674408
125PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00554088
126IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00474190
127MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00284410
128* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99989444
129STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99410284
130* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99364202
131E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98882770
132FOXP1_21924763_ChIP-Seq_HESCs_Human0.97549770
133THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97491880
134TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96914879
135KDM2B_26808549_Chip-Seq_JURKAT_Human0.96691031
136CTCF_26484167_Chip-Seq_Bcells_Mouse0.95557912

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell3.25931168
2MP0002254_reproductive_system_inflammat3.03890475
3MP0005360_urolithiasis2.96796751
4MP0008260_abnormal_autophagy2.91797263
5MP0002139_abnormal_hepatobiliary_system2.57410575
6MP0010030_abnormal_orbit_morphology2.47065050
7MP0005451_abnormal_body_composition2.45010040
8MP0005365_abnormal_bile_salt2.41452353
9MP0000685_abnormal_immune_system2.39273437
10MP0003705_abnormal_hypodermis_morpholog2.37627339
11MP0003763_abnormal_thymus_physiology2.30369134
12MP0003191_abnormal_cellular_cholesterol2.30003621
13MP0003303_peritoneal_inflammation2.26059234
14MP0003436_decreased_susceptibility_to2.20272291
15MP0003300_gastrointestinal_ulcer2.16568874
16MP0002796_impaired_skin_barrier2.14843177
17MP0010352_gastrointestinal_tract_polyps2.04893967
18MP0005083_abnormal_biliary_tract2.00997211
19MP0003123_paternal_imprinting2.00646675
20MP0005501_abnormal_skin_physiology1.93497683
21MP0003186_abnormal_redox_activity1.90464950
22MP0001835_abnormal_antigen_presentation1.89182404
23MP0009278_abnormal_bone_marrow1.88358120
24MP0009333_abnormal_splenocyte_physiolog1.87504287
25MP0008961_abnormal_basal_metabolism1.84908276
26MP0005085_abnormal_gallbladder_physiolo1.81739839
27MP0008932_abnormal_embryonic_tissue1.80171268
28MP0001800_abnormal_humoral_immune1.73609580
29MP0002398_abnormal_bone_marrow1.72958904
30MP0005671_abnormal_response_to1.71098308
31MP0000678_abnormal_parathyroid_gland1.66186112
32MP0003806_abnormal_nucleotide_metabolis1.63386462
33MP0003693_abnormal_embryo_hatching1.63308556
34MP0004947_skin_inflammation1.61894539
35MP0005464_abnormal_platelet_physiology1.61146072
36MP0002396_abnormal_hematopoietic_system1.58954014
37MP0001545_abnormal_hematopoietic_system1.57267539
38MP0005397_hematopoietic_system_phenotyp1.57267539
39MP0010155_abnormal_intestine_physiology1.55532374
40MP0002722_abnormal_immune_system1.54858427
41MP0005025_abnormal_response_to1.52897233
42MP0003172_abnormal_lysosome_physiology1.50756128
43MP0003866_abnormal_defecation1.50241203
44MP0000689_abnormal_spleen_morphology1.49907579
45MP0000609_abnormal_liver_physiology1.49896938
46MP0000490_abnormal_crypts_of1.49220227
47MP0002405_respiratory_system_inflammati1.48984633
48MP0002420_abnormal_adaptive_immunity1.47774796
49MP0010329_abnormal_lipoprotein_level1.46552349
50MP0001819_abnormal_immune_cell1.46404643
51MP0003315_abnormal_perineum_morphology1.45006606
52MP0008007_abnormal_cellular_replicative1.44679890
53MP0000716_abnormal_immune_system1.44623617
54MP0009785_altered_susceptibility_to1.44210457
55MP0009672_abnormal_birth_weight1.44188979
56MP0005000_abnormal_immune_tolerance1.44073469
57MP0005387_immune_system_phenotype1.42950126
58MP0001790_abnormal_immune_system1.42950126
59MP0002723_abnormal_immune_serum1.41391314
60MP0006036_abnormal_mitochondrial_physio1.41182177
61MP0001873_stomach_inflammation1.40587538
62MP0005076_abnormal_cell_differentiation1.39686802
63MP0001849_ear_inflammation1.39668194
64MP0002429_abnormal_blood_cell1.39485928
65MP0002452_abnormal_antigen_presenting1.38395825
66MP0002132_abnormal_respiratory_system1.37230569
67MP0008058_abnormal_DNA_repair1.37145669
68MP0000703_abnormal_thymus_morphology1.35950916
69MP0002909_abnormal_adrenal_gland1.35323086
70MP0004957_abnormal_blastocyst_morpholog1.33740352
71MP0002138_abnormal_hepatobiliary_system1.32759697
72MP0005058_abnormal_lysosome_morphology1.31743449
73MP0000858_altered_metastatic_potential1.30490244
74MP0001845_abnormal_inflammatory_respons1.27915376
75MP0003656_abnormal_erythrocyte_physiolo1.26739794
76MP0005319_abnormal_enzyme/_coenzyme1.26280850
77MP0010234_abnormal_vibrissa_follicle1.25930207
78MP0002653_abnormal_ependyma_morphology1.25145620
79MP0002166_altered_tumor_susceptibility1.24572486
80MP0004858_abnormal_nervous_system1.23878918
81MP0003786_premature_aging1.23433421
82MP0003453_abnormal_keratinocyte_physiol1.21449810
83MP0000598_abnormal_liver_morphology1.20267419
84MP0008789_abnormal_olfactory_epithelium1.19757971
85MP0001730_embryonic_growth_arrest1.19207972
86MP0003718_maternal_effect1.18090689
87MP0006035_abnormal_mitochondrial_morpho1.17233700
88MP0000537_abnormal_urethra_morphology1.16355224
89MP0001666_abnormal_nutrient_absorption1.13835488
90MP0002019_abnormal_tumor_incidence1.13799508
91MP0005499_abnormal_olfactory_system1.13191694
92MP0005394_taste/olfaction_phenotype1.13191694
93MP0003566_abnormal_cell_adhesion1.12978890
94MP0004510_myositis1.12089046
95MP0008875_abnormal_xenobiotic_pharmacok1.11989897
96MP0003941_abnormal_skin_development1.11134871
97MP0010094_abnormal_chromosome_stability1.10449873
98MP0009643_abnormal_urine_homeostasis1.10381380
99MP0006082_CNS_inflammation1.09086281
100MP0004808_abnormal_hematopoietic_stem1.07707221
101MP0008469_abnormal_protein_level1.07535308
102MP0001661_extended_life_span1.03417473
103MP0002877_abnormal_melanocyte_morpholog1.03226983
104MP0004019_abnormal_vitamin_homeostasis1.03147599
105MP0001727_abnormal_embryo_implantation1.02959643
106MP0001348_abnormal_lacrimal_gland1.02108987
107MP0003252_abnormal_bile_duct1.01900456
108MP0005023_abnormal_wound_healing0.99585577
109MP0005257_abnormal_intraocular_pressure0.98514535
110MP0002419_abnormal_innate_immunity0.97752204
111MP0000477_abnormal_intestine_morphology0.96748746
112MP0001672_abnormal_embryogenesis/_devel0.96573051
113MP0005380_embryogenesis_phenotype0.96573051
114MP0001216_abnormal_epidermal_layer0.96277631
115MP0003077_abnormal_cell_cycle0.95602469
116MP0000604_amyloidosis0.95175698
117MP0003111_abnormal_nucleus_morphology0.94449816
118MP0004782_abnormal_surfactant_physiolog0.92635532
119MP0003878_abnormal_ear_physiology0.89847988
120MP0005377_hearing/vestibular/ear_phenot0.89847988
121MP0005584_abnormal_enzyme/coenzyme_acti0.89296527
122MP0001853_heart_inflammation0.88444927
123MP0005332_abnormal_amino_acid0.88285695
124MP0002970_abnormal_white_adipose0.87822700
125MP0004272_abnormal_basement_membrane0.87737960
126MP0002089_abnormal_postnatal_growth/wei0.86986601
127MP0000358_abnormal_cell_content/0.85266186
128MP0003984_embryonic_growth_retardation0.84990495
129MP0000465_gastrointestinal_hemorrhage0.83895399
130MP0010307_abnormal_tumor_latency0.82708153
131MP0002080_prenatal_lethality0.82678612
132MP0002085_abnormal_embryonic_tissue0.82318486
133MP0003075_altered_response_to0.81695951
134MP0005220_abnormal_exocrine_pancreas0.81607584
135MP0008004_abnormal_stomach_pH0.81449134
136MP0004185_abnormal_adipocyte_glucose0.78646408
137MP0004133_heterotaxia0.78131731
138MP0000313_abnormal_cell_death0.77696749
139MP0000350_abnormal_cell_proliferation0.77249589
140MP0009931_abnormal_skin_appearance0.77244155
141MP0001915_intracranial_hemorrhage0.76724854
142MP0001533_abnormal_skeleton_physiology0.76603569
143MP0002086_abnormal_extraembryonic_tissu0.76562903
144MP0002088_abnormal_embryonic_growth/wei0.76222337
145MP0004264_abnormal_extraembryonic_tissu0.75164457
146MP0002118_abnormal_lipid_homeostasis0.73961921
147MP0001697_abnormal_embryo_size0.71700237

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)3.83536199
2Abnormal gallbladder physiology (HP:0012438)3.83536199
3Rough bone trabeculation (HP:0100670)3.50023100
4Late onset (HP:0003584)3.17450101
5Abnormality of aromatic amino acid family metabolism (HP:0004338)3.16922647
6Nasal polyposis (HP:0100582)2.94125986
7Microvesicular hepatic steatosis (HP:0001414)2.91935016
8Abnormality of the nasal mucosa (HP:0000433)2.88283115
9Hyperacusis (HP:0010780)2.87306183
10Abnormal trabecular bone morphology (HP:0100671)2.83855683
11Elevated erythrocyte sedimentation rate (HP:0003565)2.82315892
12Chronic otitis media (HP:0000389)2.74892503
13Deep venous thrombosis (HP:0002625)2.72791369
14Abnormal mitochondria in muscle tissue (HP:0008316)2.69587794
15Recurrent bronchitis (HP:0002837)2.64892543
16Abnormality of monocarboxylic acid metabolism (HP:0010996)2.61846673
17Hepatocellular necrosis (HP:0001404)2.56499521
18Acute encephalopathy (HP:0006846)2.56446808
19Abnormality of glycolysis (HP:0004366)2.56228930
20Hand muscle atrophy (HP:0009130)2.54174697
21Pustule (HP:0200039)2.53669073
22Aplasia/Hypoplasia of the sacrum (HP:0008517)2.53373400
23Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53324141
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53324141
25Acute necrotizing encephalopathy (HP:0006965)2.46043398
26Trismus (HP:0000211)2.46028305
27Multiple enchondromatosis (HP:0005701)2.43681723
28Distal lower limb muscle weakness (HP:0009053)2.41913461
29Increased serum pyruvate (HP:0003542)2.41505916
30Hypercortisolism (HP:0001578)2.40683734
31Gastrointestinal inflammation (HP:0004386)2.38842227
32Thrombocytosis (HP:0001894)2.37794516
33Polycythemia (HP:0001901)2.36339545
34Abnormality of T cells (HP:0002843)2.35998010
35Increased cerebral lipofuscin (HP:0011813)2.35849889
36Eczematoid dermatitis (HP:0000976)2.34401115
37Xanthomatosis (HP:0000991)2.34087258
38Long palpebral fissure (HP:0000637)2.29978647
39Hepatosplenomegaly (HP:0001433)2.29656332
40Abnormality of T cell physiology (HP:0011840)2.29157822
41Growth hormone excess (HP:0000845)2.29151914
42Abnormality of the motor neurons (HP:0002450)2.28681922
43Abnormal neuron morphology (HP:0012757)2.28681922
44Increased neuronal autofluorescent lipopigment (HP:0002074)2.27428057
45Abnormality of the lower motor neuron (HP:0002366)2.27417344
46Mitochondrial inheritance (HP:0001427)2.24786399
47Vacuolated lymphocytes (HP:0001922)2.24573212
48Papilloma (HP:0012740)2.23936143
49Verrucae (HP:0200043)2.23936143
50IgM deficiency (HP:0002850)2.23113396
51Recurrent fungal infections (HP:0002841)2.21442309
52Type I transferrin isoform profile (HP:0003642)2.19346512
53Hepatic necrosis (HP:0002605)2.19333497
54Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.18205989
55Hypertensive crisis (HP:0100735)2.17774071
56Angiofibromas (HP:0010615)2.17443361
57Adenoma sebaceum (HP:0009720)2.17443361
58Vertebral compression fractures (HP:0002953)2.16780206
59Basal cell carcinoma (HP:0002671)2.14759013
60Abnormal number of erythroid precursors (HP:0012131)2.14712938
61Ketosis (HP:0001946)2.14604281
62Gout (HP:0001997)2.14253127
63Increased intramyocellular lipid droplets (HP:0012240)2.13648631
64Interstitial pulmonary disease (HP:0006530)2.13643053
65Abnormality of cells of the erythroid lineage (HP:0012130)2.12358232
66Abnormal delayed hypersensitivity skin test (HP:0002963)2.12228473
67Hypoglycemic coma (HP:0001325)2.12158694
68Death in infancy (HP:0001522)2.11911224
69Increased muscle lipid content (HP:0009058)2.10848500
70Cerebral hypomyelination (HP:0006808)2.10684025
71Hemorrhage of the eye (HP:0011885)2.08985469
72Ragged-red muscle fibers (HP:0003200)2.08787893
73Purpura (HP:0000979)2.07879740
74Upper limb amyotrophy (HP:0009129)2.07809337
75Distal upper limb amyotrophy (HP:0007149)2.07809337
76Increased serum ferritin (HP:0003281)2.07707159
77T lymphocytopenia (HP:0005403)2.07013927
78Progressive neurologic deterioration (HP:0002344)2.05939461
79Increased CSF lactate (HP:0002490)2.04146648
80Colitis (HP:0002583)2.03389327
81Spastic diplegia (HP:0001264)2.03087260
82Lactic acidosis (HP:0003128)2.02858297
83Stridor (HP:0010307)2.02506549
84Inflammation of the large intestine (HP:0002037)2.01571717
85Seborrheic dermatitis (HP:0001051)2.01569941
86Urinary glycosaminoglycan excretion (HP:0003541)2.01557226
87Mucopolysacchariduria (HP:0008155)2.01557226
88Atrophy/Degeneration involving motor neurons (HP:0007373)2.01540571
89Hyperammonemia (HP:0001987)2.01495292
90Hypobetalipoproteinemia (HP:0003563)2.00217062
91Ketoacidosis (HP:0001993)2.00135944
92Insomnia (HP:0100785)1.99121188
93Recurrent viral infections (HP:0004429)1.98932738
94Dysostosis multiplex (HP:0000943)1.98559703
95Exercise intolerance (HP:0003546)1.98518186
96Sparse eyelashes (HP:0000653)1.97925293
97Respiratory difficulties (HP:0002880)1.96537971
98Progressive external ophthalmoplegia (HP:0000590)1.96337642
99Cholelithiasis (HP:0001081)1.96260508
100Secondary amenorrhea (HP:0000869)1.96224883
101Prolonged neonatal jaundice (HP:0006579)1.94776076
102Ependymoma (HP:0002888)1.93965177
103Selective tooth agenesis (HP:0001592)1.93619350
104Fasciculations (HP:0002380)1.93374871
105Reticulocytopenia (HP:0001896)1.92994680
106Neonatal onset (HP:0003623)1.92724442
107Abnormal platelet function (HP:0011869)1.92209538
108Impaired platelet aggregation (HP:0003540)1.92209538
109Personality changes (HP:0000751)1.91491596
110Chronic obstructive pulmonary disease (HP:0006510)1.90834096
111Obstructive lung disease (HP:0006536)1.90834096
112Abnormality of T cell number (HP:0011839)1.89952088
113Abnormality of endocrine pancreas physiology (HP:0012093)1.89949963
114Abnormality of the pancreatic islet cells (HP:0006476)1.89949963
115Abnormality of polysaccharide metabolism (HP:0011012)1.89635859
116Abnormality of glycosaminoglycan metabolism (HP:0004371)1.89635859
117Abnormality of mucopolysaccharide metabolism (HP:0011020)1.89635859
118Spastic paraparesis (HP:0002313)1.88444051
119Abnormality of macrophages (HP:0004311)1.88388293
120Progressive muscle weakness (HP:0003323)1.88281510
121Cerebral edema (HP:0002181)1.87689068
122Broad distal phalanx of finger (HP:0009836)1.87635062
123Increased serum lactate (HP:0002151)1.87251246
124Back pain (HP:0003418)1.87227081
125Combined immunodeficiency (HP:0005387)1.87194642
126Cellulitis (HP:0100658)1.87008397
127Abnormality of iron homeostasis (HP:0011031)1.86795884
128Abnormality of the anterior horn cell (HP:0006802)1.86651432
129Degeneration of anterior horn cells (HP:0002398)1.86651432
130Petechiae (HP:0000967)1.86416006
131Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85196099
132Abnormal protein N-linked glycosylation (HP:0012347)1.85196099
133Abnormal protein glycosylation (HP:0012346)1.85196099
134Abnormal glycosylation (HP:0012345)1.85196099
135Abnormality of the distal phalanges of the toes (HP:0010182)1.84977594
136Increased IgM level (HP:0003496)1.83438710
137Myopathic facies (HP:0002058)1.82896573
138Deep palmar crease (HP:0006191)1.82110981
139Neoplasm of the heart (HP:0100544)1.81727320
140Abnormality of the umbilical cord (HP:0010881)1.81530969
141Abnormality of the Achilles tendon (HP:0005109)1.79373144
142Generalized hyperpigmentation (HP:0007440)1.79141796
143Abnormality of complement system (HP:0005339)1.78069827
144Centrally nucleated skeletal muscle fibers (HP:0003687)1.77668243
145Oral leukoplakia (HP:0002745)1.77649104
146Hypokinesia (HP:0002375)1.77359105
147Abnormality of alkaline phosphatase activity (HP:0004379)1.76765513
148Panhypogammaglobulinemia (HP:0003139)1.76761224
149Abnormal gallbladder morphology (HP:0012437)1.76037320
150Amyotrophic lateral sclerosis (HP:0007354)1.75817114
151Recurrent gram-negative bacterial infections (HP:0005420)1.75501683
152Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75443007
153Complement deficiency (HP:0004431)1.74905753
154Upper motor neuron abnormality (HP:0002127)1.73731873
155Squamous cell carcinoma (HP:0002860)1.73328345
156Truncus arteriosus (HP:0001660)1.73301684
157Microretrognathia (HP:0000308)1.73015313
158Emotional lability (HP:0000712)1.72971675
159Abnormality of the gallbladder (HP:0005264)1.72113709
160Abnormality of transition element cation homeostasis (HP:0011030)1.72051796
161Abnormal enzyme/coenzyme activity (HP:0012379)1.71883792
162Spontaneous hematomas (HP:0007420)1.71248660
163Joint swelling (HP:0001386)1.71054166
164Loss of speech (HP:0002371)1.70855865
165Reduced antithrombin III activity (HP:0001976)1.70608929
166Urticaria (HP:0001025)1.69761435
167Gastrointestinal dysmotility (HP:0002579)1.68357088
168Increased IgE level (HP:0003212)1.66477477
169Poikiloderma (HP:0001029)1.65660369
170Chest pain (HP:0100749)1.65299417
171Renal Fanconi syndrome (HP:0001994)1.65041993
172Autoimmune thrombocytopenia (HP:0001973)1.64198369
173Long toe (HP:0010511)1.64100169
174Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.64090099
175Elfin facies (HP:0004428)1.63404594
176Systemic lupus erythematosus (HP:0002725)1.63304883
177Achilles tendon contracture (HP:0001771)1.63103863
178Hypochromic anemia (HP:0001931)1.62685423
179Insulin resistance (HP:0000855)1.62423312
180Epistaxis (HP:0000421)1.62379253

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.16697987
2ERN14.03134240
3VRK23.64084310
4SMG13.47328511
5EPHA23.35855005
6MAP4K13.14404217
7MAP3K103.04886166
8PKN23.00261322
9EEF2K2.92351210
10TESK22.73742192
11IRAK32.16420965
12FGFR42.09439341
13STK162.06855387
14MAP3K112.06607832
15KDR1.99588544
16GRK61.99256887
17BCKDK1.94197508
18ARAF1.92842028
19ZAP701.89385457
20SRPK11.79421485
21TESK11.72630365
22MAPKAPK31.69841971
23SCYL21.68580201
24PBK1.59078920
25LRRK21.55980256
26BLK1.51722319
27SIK11.49335864
28TAOK11.45589003
29TBK11.39390435
30SIK31.37922876
31NME11.33288328
32NEK11.32753240
33FLT31.30324737
34STK101.27149261
35TYK21.25714767
36JAK31.23780064
37TSSK61.23163318
38MAP2K31.21929226
39BRAF1.20265768
40PIM21.20127244
41NME21.19638726
42PTK61.15743394
43BTK1.14801645
44KSR21.13501546
45MAP3K31.13216611
46TTK1.10066587
47RPS6KA41.09653730
48ICK1.09383071
49LMTK21.09234232
50RIPK11.08992378
51EPHB11.07650528
52MST1R1.07186701
53DAPK11.03946437
54PAK41.03940186
55ABL21.01669198
56PASK0.97877678
57PDK20.96918877
58DYRK1B0.96485233
59MST40.95488573
60MAP2K20.91894254
61ITK0.91884461
62MATK0.91150859
63BUB10.90817582
64SIK20.90231891
65ALK0.89888677
66CDK190.89693662
67MAP3K80.87274934
68NEK20.86527333
69PRPF4B0.86060643
70LIMK10.84562541
71MAP2K60.83320786
72MAPK110.82742903
73HIPK20.82392347
74SYK0.82088811
75CSK0.78187670
76RPS6KB20.77307530
77CSNK1G30.73133010
78IKBKE0.71556859
79CDC70.69917813
80PDGFRA0.69410117
81TGFBR10.69329171
82IRAK40.69299071
83DYRK20.69194629
84MAP3K90.69072770
85CDK40.68961949
86PTK20.68439381
87TIE10.68053780
88PAK10.67516603
89JAK20.67384768
90MAP3K10.66560222
91CDK120.66422684
92ILK0.64170538
93BMX0.62381893
94TRIM280.61707255
95PRKCI0.59898030
96TYRO30.59717226
97EIF2AK10.56843511
98PRKG20.56359946
99CAMKK10.54935334
100CSF1R0.54462431
101PIM10.53646314
102RPS6KA20.53610977
103PRKD30.53461312
104DAPK30.53211248
105HCK0.53007649
106JAK10.52574936
107RPS6KA10.51979001
108STK40.51937078
109VRK10.51101179
110MTOR0.50693242
111KIT0.50441847
112CDK70.50195177
113DYRK30.49995814
114LCK0.49750528
115PLK10.46861598
116FGFR30.45674164
117BRSK10.45542275
118TAOK20.44874791
119FGR0.43794876
120PRKD20.43675205
121CSNK1A1L0.42284514
122RET0.42104618
123RPS6KL10.41940033
124RPS6KC10.41940033
125DAPK20.41733641
126RPS6KA60.41670179
127CSNK1G10.40707214
128IRAK20.40310648
129IKBKB0.39743366
130TGFBR20.37157793
131AKT20.36590678
132UHMK10.36264691
133MAP3K70.36173250
134CSNK2A20.36057931
135NTRK10.35445232
136ACVR1B0.34837445
137RAF10.34554742
138CHUK0.33898508
139CDK60.33732326
140MARK20.33021919
141AURKA0.32991624
142TXK0.32279148
143AURKB0.32153779
144CSNK2A10.32042865
145MAPKAPK20.31152867
146CDK90.29797737
147CDK140.28737765
148CHEK20.27454847

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.74229954
2Sulfur relay system_Homo sapiens_hsa041222.42611545
3Primary immunodeficiency_Homo sapiens_hsa053402.23691052
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.11954273
5DNA replication_Homo sapiens_hsa030302.01449358
6Fatty acid elongation_Homo sapiens_hsa000622.00315616
7Nitrogen metabolism_Homo sapiens_hsa009101.89526990
8Biosynthesis of amino acids_Homo sapiens_hsa012301.86220259
9RNA polymerase_Homo sapiens_hsa030201.83595023
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.81305729
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.79985608
12Pyrimidine metabolism_Homo sapiens_hsa002401.78697663
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.76070723
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71985562
15Arginine biosynthesis_Homo sapiens_hsa002201.71474965
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69418514
17Pentose phosphate pathway_Homo sapiens_hsa000301.64388836
18Oxidative phosphorylation_Homo sapiens_hsa001901.62367978
19Base excision repair_Homo sapiens_hsa034101.60309231
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59855366
21Glutathione metabolism_Homo sapiens_hsa004801.58678231
22Acute myeloid leukemia_Homo sapiens_hsa052211.53461650
23Parkinsons disease_Homo sapiens_hsa050121.52688202
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.52017829
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.50564297
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48418260
27Antigen processing and presentation_Homo sapiens_hsa046121.45907520
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44241942
29B cell receptor signaling pathway_Homo sapiens_hsa046621.40855856
30Folate biosynthesis_Homo sapiens_hsa007901.40056528
31Carbon metabolism_Homo sapiens_hsa012001.40045338
32Selenocompound metabolism_Homo sapiens_hsa004501.39333875
33Chronic myeloid leukemia_Homo sapiens_hsa052201.37732116
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35660440
35Vibrio cholerae infection_Homo sapiens_hsa051101.33621440
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33337388
37Shigellosis_Homo sapiens_hsa051311.29747742
38VEGF signaling pathway_Homo sapiens_hsa043701.28228753
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25559316
40Huntingtons disease_Homo sapiens_hsa050161.24726321
41Bladder cancer_Homo sapiens_hsa052191.23991193
42Mismatch repair_Homo sapiens_hsa034301.23813673
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.22898990
44Ribosome_Homo sapiens_hsa030101.20767248
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.20519231
46Galactose metabolism_Homo sapiens_hsa000521.20357035
47Leishmaniasis_Homo sapiens_hsa051401.19073340
48Fructose and mannose metabolism_Homo sapiens_hsa000511.18791714
49T cell receptor signaling pathway_Homo sapiens_hsa046601.17184689
50Tryptophan metabolism_Homo sapiens_hsa003801.15799061
51Thyroid cancer_Homo sapiens_hsa052161.12970811
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11834862
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11561340
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11536512
55Spliceosome_Homo sapiens_hsa030401.09754843
56Caffeine metabolism_Homo sapiens_hsa002321.07340437
57Legionellosis_Homo sapiens_hsa051341.07110465
58mTOR signaling pathway_Homo sapiens_hsa041501.07035959
59Apoptosis_Homo sapiens_hsa042101.05506582
60Staphylococcus aureus infection_Homo sapiens_hsa051501.05340939
61Fatty acid degradation_Homo sapiens_hsa000711.04951464
62Neurotrophin signaling pathway_Homo sapiens_hsa047221.04873648
63Non-small cell lung cancer_Homo sapiens_hsa052231.04470334
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03858559
65One carbon pool by folate_Homo sapiens_hsa006701.02518152
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01073772
67Sulfur metabolism_Homo sapiens_hsa009200.99373998
68Steroid biosynthesis_Homo sapiens_hsa001000.98677630
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98299253
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97098957
71Notch signaling pathway_Homo sapiens_hsa043300.94697521
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94442997
73Non-homologous end-joining_Homo sapiens_hsa034500.92880020
74Insulin resistance_Homo sapiens_hsa049310.92838975
75Measles_Homo sapiens_hsa051620.89293919
76N-Glycan biosynthesis_Homo sapiens_hsa005100.87967707
77Phenylalanine metabolism_Homo sapiens_hsa003600.86973863
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84722835
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84440497
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.83381185
81Vitamin B6 metabolism_Homo sapiens_hsa007500.82859271
82Prolactin signaling pathway_Homo sapiens_hsa049170.82387956
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82157300
84Complement and coagulation cascades_Homo sapiens_hsa046100.81824907
85Insulin signaling pathway_Homo sapiens_hsa049100.80983931
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80741167
87Arginine and proline metabolism_Homo sapiens_hsa003300.80531029
88Osteoclast differentiation_Homo sapiens_hsa043800.80143218
89Fat digestion and absorption_Homo sapiens_hsa049750.79913016
90Bile secretion_Homo sapiens_hsa049760.79058017
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78326535
92Colorectal cancer_Homo sapiens_hsa052100.76744334
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75198649
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73923751
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71613794
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71457311
97Alzheimers disease_Homo sapiens_hsa050100.71150513
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70420301
99Metabolic pathways_Homo sapiens_hsa011000.70337446
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69928619
101Proteasome_Homo sapiens_hsa030500.68887754
102Lysosome_Homo sapiens_hsa041420.68498449
103Pancreatic cancer_Homo sapiens_hsa052120.68267258
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67294147
105Endometrial cancer_Homo sapiens_hsa052130.67025062
106Hepatitis B_Homo sapiens_hsa051610.66105279
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66051891
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.64957712
109Lysine degradation_Homo sapiens_hsa003100.64092985
110HTLV-I infection_Homo sapiens_hsa051660.63226088
111Vitamin digestion and absorption_Homo sapiens_hsa049770.62752573
112Purine metabolism_Homo sapiens_hsa002300.61883624
113Viral myocarditis_Homo sapiens_hsa054160.61799808
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.60833244
115Pyruvate metabolism_Homo sapiens_hsa006200.60699743
116Prion diseases_Homo sapiens_hsa050200.59451852
117Salmonella infection_Homo sapiens_hsa051320.59157757
118Collecting duct acid secretion_Homo sapiens_hsa049660.59155684
119Nucleotide excision repair_Homo sapiens_hsa034200.59015622
120Epstein-Barr virus infection_Homo sapiens_hsa051690.58377037
121Tyrosine metabolism_Homo sapiens_hsa003500.57059840
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.56997866
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56445930
124Herpes simplex infection_Homo sapiens_hsa051680.55994595
125RNA transport_Homo sapiens_hsa030130.55878219
126Cell cycle_Homo sapiens_hsa041100.54389567
127Viral carcinogenesis_Homo sapiens_hsa052030.54378048
128Influenza A_Homo sapiens_hsa051640.53406237
129Other glycan degradation_Homo sapiens_hsa005110.53342289
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53181110
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52071743
132Toxoplasmosis_Homo sapiens_hsa051450.51833703
133p53 signaling pathway_Homo sapiens_hsa041150.51376766
134AMPK signaling pathway_Homo sapiens_hsa041520.50961523
135mRNA surveillance pathway_Homo sapiens_hsa030150.47400188
136Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46750099
137Fatty acid metabolism_Homo sapiens_hsa012120.46070273
138Peroxisome_Homo sapiens_hsa041460.38362333
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37492927
140Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37242683
141Endocytosis_Homo sapiens_hsa041440.36429139
142Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34356759
143Phagosome_Homo sapiens_hsa041450.29064003
144Hepatitis C_Homo sapiens_hsa051600.27270156

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