LYPLAL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)7.05216448
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.57720082
3L-phenylalanine catabolic process (GO:0006559)6.57720082
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.26088269
5L-phenylalanine metabolic process (GO:0006558)6.26088269
6aromatic amino acid family catabolic process (GO:0009074)5.65538337
7lysine metabolic process (GO:0006553)5.61104250
8lysine catabolic process (GO:0006554)5.61104250
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.19955793
10cysteine metabolic process (GO:0006534)5.01262226
11glyoxylate metabolic process (GO:0046487)4.96443313
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.75150594
13indole-containing compound catabolic process (GO:0042436)4.69649729
14indolalkylamine catabolic process (GO:0046218)4.69649729
15tryptophan catabolic process (GO:0006569)4.69649729
16tryptophan metabolic process (GO:0006568)4.67573842
17drug transmembrane transport (GO:0006855)4.63414053
18Golgi transport vesicle coating (GO:0048200)4.60727941
19COPI coating of Golgi vesicle (GO:0048205)4.60727941
20urate metabolic process (GO:0046415)4.51508841
21tyrosine metabolic process (GO:0006570)4.50415904
22protein complex biogenesis (GO:0070271)4.47163012
23kynurenine metabolic process (GO:0070189)4.45960753
24platelet dense granule organization (GO:0060155)4.36147378
25aromatic amino acid family metabolic process (GO:0009072)4.31892340
26ATP synthesis coupled proton transport (GO:0015986)4.31080279
27energy coupled proton transport, down electrochemical gradient (GO:0015985)4.31080279
28DNA double-strand break processing (GO:0000729)4.30676679
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.28269713
30mitochondrial respiratory chain complex I assembly (GO:0032981)4.28269713
31NADH dehydrogenase complex assembly (GO:0010257)4.28269713
32proteasome assembly (GO:0043248)4.25160526
33mitochondrial respiratory chain complex assembly (GO:0033108)4.25103334
34respiratory electron transport chain (GO:0022904)4.18805473
35sulfur amino acid catabolic process (GO:0000098)4.17737448
36electron transport chain (GO:0022900)4.14015882
37organelle disassembly (GO:1903008)4.04790145
38cullin deneddylation (GO:0010388)3.97231648
39aldehyde catabolic process (GO:0046185)3.93007743
40branched-chain amino acid catabolic process (GO:0009083)3.89099764
41aspartate family amino acid catabolic process (GO:0009068)3.89049712
42cellular ketone body metabolic process (GO:0046950)3.87255304
43drug transport (GO:0015893)3.85810745
44bile acid biosynthetic process (GO:0006699)3.80648669
45homocysteine metabolic process (GO:0050667)3.80369200
46respiratory chain complex IV assembly (GO:0008535)3.78074960
47serine family amino acid catabolic process (GO:0009071)3.77845909
48indolalkylamine metabolic process (GO:0006586)3.76894690
49branched-chain amino acid metabolic process (GO:0009081)3.76873236
50endocrine pancreas development (GO:0031018)3.74795083
51short-chain fatty acid metabolic process (GO:0046459)3.73706549
52alpha-amino acid catabolic process (GO:1901606)3.62441229
53cellular amino acid catabolic process (GO:0009063)3.56985105
54benzene-containing compound metabolic process (GO:0042537)3.54130416
55COPII vesicle coating (GO:0048208)3.54073838
56protein carboxylation (GO:0018214)3.52558131
57peptidyl-glutamic acid carboxylation (GO:0017187)3.52558131
58fatty acid beta-oxidation (GO:0006635)3.49775013
59valine metabolic process (GO:0006573)3.49236625
60fatty acid oxidation (GO:0019395)3.48983598
61relaxation of smooth muscle (GO:0044557)3.48421390
62amino-acid betaine metabolic process (GO:0006577)3.45891727
63acetyl-CoA metabolic process (GO:0006084)3.44313557
64tricarboxylic acid metabolic process (GO:0072350)3.41962221
65protein deneddylation (GO:0000338)3.41840879
66chaperone-mediated protein transport (GO:0072321)3.41237036
67amine catabolic process (GO:0009310)3.39933399
68cellular biogenic amine catabolic process (GO:0042402)3.39933399
69lipid oxidation (GO:0034440)3.39630354
70fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.38701736
712-oxoglutarate metabolic process (GO:0006103)3.37016631
72L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.36647162
73ketone body metabolic process (GO:1902224)3.35939934
74proline metabolic process (GO:0006560)3.32899309
75cellular modified amino acid catabolic process (GO:0042219)3.28600889
76coenzyme catabolic process (GO:0009109)3.28258228
77establishment of protein localization to mitochondrial membrane (GO:0090151)3.28137236
78organic acid catabolic process (GO:0016054)3.27391567
79carboxylic acid catabolic process (GO:0046395)3.27391567
80cytochrome complex assembly (GO:0017004)3.26989986
81water-soluble vitamin biosynthetic process (GO:0042364)3.26968102
82protein-cofactor linkage (GO:0018065)3.26409218
83bile acid metabolic process (GO:0008206)3.26369292
84cellular glucuronidation (GO:0052695)3.24347573
85serine family amino acid metabolic process (GO:0009069)3.23415406
86alpha-linolenic acid metabolic process (GO:0036109)3.20331665
87ribonucleoprotein complex disassembly (GO:0032988)3.19558779
88triglyceride homeostasis (GO:0070328)3.19014066
89acylglycerol homeostasis (GO:0055090)3.19014066
90fatty acid catabolic process (GO:0009062)3.16799895
91uronic acid metabolic process (GO:0006063)3.16063818
92glucuronate metabolic process (GO:0019585)3.16063818
93drug catabolic process (GO:0042737)3.15749817
94monocarboxylic acid catabolic process (GO:0072329)3.15056017
95regulation of cilium movement (GO:0003352)3.13712576
96regulation of hexokinase activity (GO:1903299)3.11693498
97regulation of glucokinase activity (GO:0033131)3.11693498
98negative regulation of heart rate (GO:0010459)3.10110006
99negative regulation of response to food (GO:0032096)3.05900674
100negative regulation of appetite (GO:0032099)3.05900674
101response to mercury ion (GO:0046689)3.05436663
102glutamate metabolic process (GO:0006536)3.04010176
103prenylation (GO:0097354)3.03452958
104protein prenylation (GO:0018342)3.03452958
105xenobiotic catabolic process (GO:0042178)3.00518061
106peptidyl-histidine modification (GO:0018202)2.98800413
107methionine biosynthetic process (GO:0009086)2.98247784
108positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.97328491
1093-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.96275402
110purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.96275402
111drug metabolic process (GO:0017144)2.95856163
112organic cation transport (GO:0015695)2.94329718
113lactate metabolic process (GO:0006089)2.94109828
114nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93286018
115nucleoside bisphosphate metabolic process (GO:0033865)2.93046049
116purine nucleoside bisphosphate metabolic process (GO:0034032)2.93046049
117ribonucleoside bisphosphate metabolic process (GO:0033875)2.93046049
118signal peptide processing (GO:0006465)2.92481098
119heart process (GO:0003015)2.90659680
120heart contraction (GO:0060047)2.90659680
121coenzyme A metabolic process (GO:0015936)2.90354922
122hydrogen ion transmembrane transport (GO:1902600)2.89871472
123exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.88219213
124L-methionine salvage (GO:0071267)2.87692193
125L-methionine biosynthetic process (GO:0071265)2.87692193
126amino acid salvage (GO:0043102)2.87692193
127triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.87262591
128oxaloacetate metabolic process (GO:0006107)2.85608191
129regulation of fibrinolysis (GO:0051917)2.84685536
130imidazole-containing compound metabolic process (GO:0052803)2.83627820
131negative regulation of fibrinolysis (GO:0051918)2.83279178
132peroxisome fission (GO:0016559)2.82434558
133maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.82290470
134proline biosynthetic process (GO:0006561)2.81963590
135carnitine metabolic process (GO:0009437)2.80819698
136negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.80672388
137small molecule catabolic process (GO:0044282)2.80452984
138methionine metabolic process (GO:0006555)2.80348170
139preassembly of GPI anchor in ER membrane (GO:0016254)2.79138895
140phosphate ion transport (GO:0006817)2.77989388
141dopamine transport (GO:0015872)2.77249269
142regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.76919656
143indole-containing compound metabolic process (GO:0042430)2.75503112
144regulation of cholesterol esterification (GO:0010872)2.75178984
145urea cycle (GO:0000050)2.74707608
146urea metabolic process (GO:0019627)2.74707608
147retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.73842829
148sequestering of actin monomers (GO:0042989)2.73589022
149protein targeting to mitochondrion (GO:0006626)2.73336540
150anterograde synaptic vesicle transport (GO:0048490)2.73243213
151biotin metabolic process (GO:0006768)2.72396561
152proton transport (GO:0015992)2.72081869
153C-terminal protein lipidation (GO:0006501)2.71513025
154flavonoid metabolic process (GO:0009812)2.71365484
155toxin metabolic process (GO:0009404)2.71272522
156CENP-A containing nucleosome assembly (GO:0034080)2.69747919
157ATP biosynthetic process (GO:0006754)2.69685453
158fatty acid elongation (GO:0030497)2.68941922
159hydrogen transport (GO:0006818)2.67823244
160protein K11-linked ubiquitination (GO:0070979)2.66951696
161intraciliary transport (GO:0042073)2.66636845
162chromatin remodeling at centromere (GO:0031055)2.66135515
163regulation of acyl-CoA biosynthetic process (GO:0050812)2.65152980
164regulation of mitochondrial translation (GO:0070129)2.64253322
165response to nitrosative stress (GO:0051409)2.62898574
166GPI anchor metabolic process (GO:0006505)2.61695929
167phospholipid homeostasis (GO:0055091)2.61466811
168glutathione derivative metabolic process (GO:1901685)2.61430604
169glutathione derivative biosynthetic process (GO:1901687)2.61430604
170response to redox state (GO:0051775)2.61304391
171adenosine metabolic process (GO:0046085)2.60453095
172protein localization to mitochondrion (GO:0070585)2.60314823
173pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.59947332
174reverse cholesterol transport (GO:0043691)2.58061972
175termination of RNA polymerase III transcription (GO:0006386)2.55621880
176transcription elongation from RNA polymerase III promoter (GO:0006385)2.55621880
177establishment of protein localization to mitochondrion (GO:0072655)2.55169130
178rRNA modification (GO:0000154)2.54589186
179high-density lipoprotein particle remodeling (GO:0034375)2.54354737
180ATP hydrolysis coupled proton transport (GO:0015991)2.52809906
181energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.52809906
182mitochondrial transport (GO:0006839)2.51145979
183inner mitochondrial membrane organization (GO:0007007)2.50597086
184positive regulation of mitochondrial fission (GO:0090141)2.50173544
185protein localization to cilium (GO:0061512)2.49750575
186sulfur amino acid biosynthetic process (GO:0000097)2.46664697
187C-terminal protein amino acid modification (GO:0018410)2.46205515
188rRNA methylation (GO:0031167)2.43701673
189histone mRNA metabolic process (GO:0008334)2.42926710
190purine nucleoside triphosphate biosynthetic process (GO:0009145)2.42414310
191regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.42266269
192DNA catabolic process, exonucleolytic (GO:0000738)2.41270351

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.80042271
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.27471568
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.32333973
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.06368675
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.01853968
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.49033028
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.48535462
8PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.17766772
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.90175076
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.81934245
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.81798161
12ELK1_19687146_ChIP-ChIP_HELA_Human2.70121743
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.68818339
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.57905850
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.48285439
16EWS_26573619_Chip-Seq_HEK293_Human2.39024645
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.23968261
18IGF1R_20145208_ChIP-Seq_DFB_Human2.22556280
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.18559518
20TAF15_26573619_Chip-Seq_HEK293_Human2.17951035
21FUS_26573619_Chip-Seq_HEK293_Human2.11798226
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06074219
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05410250
24* P300_19829295_ChIP-Seq_ESCs_Human1.97075376
25VDR_23849224_ChIP-Seq_CD4+_Human1.94043512
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90478890
27VDR_22108803_ChIP-Seq_LS180_Human1.90097297
28ZNF274_21170338_ChIP-Seq_K562_Hela1.89447622
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.81441696
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78069464
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76699045
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75803155
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68738691
34* EZH2_27294783_Chip-Seq_NPCs_Mouse1.66935024
35GATA1_22025678_ChIP-Seq_K562_Human1.65122439
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.64351952
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63812700
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61286700
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54128428
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.52255036
41ER_23166858_ChIP-Seq_MCF-7_Human1.50401786
42* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50004334
43CLOCK_20551151_ChIP-Seq_293T_Human1.48276257
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47964973
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.46180171
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.44446654
47* NFE2_27457419_Chip-Seq_LIVER_Mouse1.41118821
48* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40713513
49FOXP3_21729870_ChIP-Seq_TREG_Human1.40049354
50* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38542638
51SALL4_22934838_ChIP-ChIP_CD34+_Human1.38501752
52MYC_18940864_ChIP-ChIP_HL60_Human1.37109468
53ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.36174086
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36134876
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35619958
56* CRX_20693478_ChIP-Seq_RETINA_Mouse1.34909075
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.34690532
58* P53_22387025_ChIP-Seq_ESCs_Mouse1.32583440
59* NANOG_18555785_Chip-Seq_ESCs_Mouse1.32512683
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.31783663
61SMAD4_21799915_ChIP-Seq_A2780_Human1.31525995
62* GBX2_23144817_ChIP-Seq_PC3_Human1.29786849
63* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29757355
64* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27341283
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.27205079
66* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27159586
67TP53_22573176_ChIP-Seq_HFKS_Human1.27012368
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26206784
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26159457
70* AR_25329375_ChIP-Seq_VCAP_Human1.25420920
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.24547741
72* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22605230
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22254304
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21573681
75CBP_20019798_ChIP-Seq_JUKART_Human1.21353001
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21353001
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.20734065
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20313227
79* E2F1_18555785_Chip-Seq_ESCs_Mouse1.16358026
80REST_19997604_ChIP-ChIP_NEURONS_Mouse1.16154005
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15016717
82* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11687440
83TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.10886343
84* CMYC_18555785_Chip-Seq_ESCs_Mouse1.10751302
85SOX17_20123909_ChIP-Seq_XEN_Mouse1.10080259
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09974732
87HNF4A_19822575_ChIP-Seq_HepG2_Human1.09413689
88* STAT3_18555785_Chip-Seq_ESCs_Mouse1.09151080
89* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09101928
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08830925
91FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.08478040
92* P300_18555785_Chip-Seq_ESCs_Mouse1.07728006
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07081659
94* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06588839
95* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06564215
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.05451584
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03982644
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03826905
99* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03492605
100TCF4_22108803_ChIP-Seq_LS180_Human1.02936732
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02615655
102* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00592596
103FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00343467
104FOXA1_25329375_ChIP-Seq_VCAP_Human1.00343467
105* SOX2_18555785_Chip-Seq_ESCs_Mouse1.00276142
106JUN_21703547_ChIP-Seq_K562_Human1.00144682
107THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99918351
108* PHF8_20622853_ChIP-Seq_HELA_Human0.99586878
109HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99377467
110* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99359729
111FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98058116
112AR_20517297_ChIP-Seq_VCAP_Human0.96733398
113SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96048002
114DCP1A_22483619_ChIP-Seq_HELA_Human0.95464438
115BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94951219
116KAP1_22055183_ChIP-Seq_ESCs_Mouse0.92458259
117SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88953978
118FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88292569
119IRF1_19129219_ChIP-ChIP_H3396_Human0.87826820
120FOXA2_19822575_ChIP-Seq_HepG2_Human0.87266460
121HTT_18923047_ChIP-ChIP_STHdh_Human0.87150743
122PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87083728
123ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84320692
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80875112
125BCAT_22108803_ChIP-Seq_LS180_Human0.80736089
126PADI4_21655091_ChIP-ChIP_MCF-7_Human0.79444328
127ZFX_18555785_ChIP-Seq_MESCs_Mouse0.78034056
128TOP2B_26459242_ChIP-Seq_MCF-7_Human0.77823733
129SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.76784061
130ETS1_20019798_ChIP-Seq_JURKAT_Human0.76573853
131SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.76392396
132TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76330023
133AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76257676
134GATA4_25053715_ChIP-Seq_YYC3_Human0.75749879
135* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.74518872
136* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.71631924
137SOX2_18692474_ChIP-Seq_MEFs_Mouse0.71182310
138ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70656595
139SOX2_19829295_ChIP-Seq_ESCs_Human0.69487117
140NANOG_19829295_ChIP-Seq_ESCs_Human0.69487117
141GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.68694426
142GABP_19822575_ChIP-Seq_HepG2_Human0.68663729
143CDX2_22108803_ChIP-Seq_LS180_Human0.68469887
144FOXA1_25552417_ChIP-Seq_VCAP_Human0.68341174
145POU3F2_20337985_ChIP-ChIP_501MEL_Human0.68279609
146SOX2_20726797_ChIP-Seq_SW620_Human0.68057849
147NANOG_21062744_ChIP-ChIP_HESCs_Human0.67870386
148PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.67621695
149* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.67378634
150EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.67064894
151FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.66564675
152GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.66018737
153* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65938935
154* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65938935
155SOX2_22085726_ChIP-Seq_NPCs_Mouse0.65776134
156FLI1_27457419_Chip-Seq_LIVER_Mouse0.65633327
157STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.65307373
158NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.65123520
159SALL1_21062744_ChIP-ChIP_HESCs_Human0.64338328
160ERG_20517297_ChIP-Seq_VCAP_Human0.62967345
161FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.62813669
162NELFA_20434984_ChIP-Seq_ESCs_Mouse0.62773234

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.90917112
2MP0002139_abnormal_hepatobiliary_system5.87263270
3MP0005365_abnormal_bile_salt4.40398727
4MP0004043_abnormal_pH_regulation4.06229517
5MP0005085_abnormal_gallbladder_physiolo4.03405385
6MP0003195_calcinosis3.91612117
7MP0003806_abnormal_nucleotide_metabolis3.79626190
8MP0008875_abnormal_xenobiotic_pharmacok3.75413004
9MP0000372_irregular_coat_pigmentation3.09562156
10MP0002102_abnormal_ear_morphology3.04312482
11MP0005332_abnormal_amino_acid3.01670795
12MP0003011_delayed_dark_adaptation2.85982554
13MP0004215_abnormal_myocardial_fiber2.83677790
14MP0003252_abnormal_bile_duct2.80006228
15MP0005464_abnormal_platelet_physiology2.68329729
16MP0002837_dystrophic_cardiac_calcinosis2.65028779
17MP0010386_abnormal_urinary_bladder2.49701608
18MP0002138_abnormal_hepatobiliary_system2.45756276
19MP0003283_abnormal_digestive_organ2.43228777
20MP0004019_abnormal_vitamin_homeostasis2.28734081
21MP0001529_abnormal_vocalization2.25062042
22MP0009643_abnormal_urine_homeostasis2.22292774
23MP0001984_abnormal_olfaction2.15458783
24MP0003136_yellow_coat_color2.08897816
25MP0002876_abnormal_thyroid_physiology1.98975101
26MP0002736_abnormal_nociception_after1.97545666
27MP0004084_abnormal_cardiac_muscle1.96979443
28MP0005220_abnormal_exocrine_pancreas1.91941194
29MP0008004_abnormal_stomach_pH1.90034392
30MP0005551_abnormal_eye_electrophysiolog1.87667286
31MP0005636_abnormal_mineral_homeostasis1.86086496
32MP0008058_abnormal_DNA_repair1.80611517
33MP0000678_abnormal_parathyroid_gland1.77353320
34MP0001764_abnormal_homeostasis1.75749467
35MP0005408_hypopigmentation1.75262553
36MP0010329_abnormal_lipoprotein_level1.75156280
37MP0008789_abnormal_olfactory_epithelium1.74650914
38MP0001666_abnormal_nutrient_absorption1.70871150
39MP0001944_abnormal_pancreas_morphology1.70672711
40MP0009780_abnormal_chondrocyte_physiolo1.70552901
41MP0005083_abnormal_biliary_tract1.70045892
42MP0001756_abnormal_urination1.69113861
43MP0002090_abnormal_vision1.65165599
44MP0005253_abnormal_eye_physiology1.64463755
45MP0008872_abnormal_physiological_respon1.60429119
46MP0005084_abnormal_gallbladder_morpholo1.57993910
47MP0001485_abnormal_pinna_reflex1.57215719
48MP0002693_abnormal_pancreas_physiology1.56894360
49MP0002877_abnormal_melanocyte_morpholog1.55509567
50MP0003868_abnormal_feces_composition1.54238828
51MP0005379_endocrine/exocrine_gland_phen1.53918528
52MP0000013_abnormal_adipose_tissue1.51059656
53MP0005187_abnormal_penis_morphology1.50175920
54MP0000538_abnormal_urinary_bladder1.48246729
55MP0005410_abnormal_fertilization1.46097700
56MP0001765_abnormal_ion_homeostasis1.43963012
57MP0003186_abnormal_redox_activity1.41222709
58MP0008877_abnormal_DNA_methylation1.40542538
59MP0002118_abnormal_lipid_homeostasis1.39807143
60MP0002638_abnormal_pupillary_reflex1.39451217
61MP0004133_heterotaxia1.39415726
62MP0002078_abnormal_glucose_homeostasis1.37710082
63MP0003137_abnormal_impulse_conducting1.36458949
64MP0009046_muscle_twitch1.36228491
65MP0003786_premature_aging1.34151255
66MP0005499_abnormal_olfactory_system1.33376693
67MP0005394_taste/olfaction_phenotype1.33376693
68MP0002234_abnormal_pharynx_morphology1.31357039
69MP0004142_abnormal_muscle_tone1.28334932
70MP0006036_abnormal_mitochondrial_physio1.27472390
71MP0004085_abnormal_heartbeat1.26899866
72MP0008775_abnormal_heart_ventricle1.21600909
73MP0004036_abnormal_muscle_relaxation1.21557835
74MP0000647_abnormal_sebaceous_gland1.19449441
75MP0009697_abnormal_copulation1.18762585
76MP0000358_abnormal_cell_content/1.18601606
77MP0005646_abnormal_pituitary_gland1.13586226
78MP0005319_abnormal_enzyme/_coenzyme1.12715546
79MP0001968_abnormal_touch/_nociception1.11087071
80MP0008995_early_reproductive_senescence1.10859314
81MP0000609_abnormal_liver_physiology1.09839045
82MP0003880_abnormal_central_pattern1.09132281
83MP0002132_abnormal_respiratory_system1.08032315
84MP0004147_increased_porphyrin_level1.04253237
85MP0005058_abnormal_lysosome_morphology1.02193273
86MP0003122_maternal_imprinting1.01958687
87MP0002972_abnormal_cardiac_muscle1.00671897
88MP0004264_abnormal_extraembryonic_tissu1.00010941
89MP0006072_abnormal_retinal_apoptosis0.99959138
90MP0002909_abnormal_adrenal_gland0.99016966
91MP0005584_abnormal_enzyme/coenzyme_acti0.98203563
92MP0005535_abnormal_body_temperature0.98144165
93MP0002163_abnormal_gland_morphology0.96808320
94MP0004782_abnormal_surfactant_physiolog0.94825408
95MP0001324_abnormal_eye_pigmentation0.94733053
96MP0000343_altered_response_to0.94481768
97MP0001293_anophthalmia0.94163505
98MP0002928_abnormal_bile_duct0.93495753
99MP0002233_abnormal_nose_morphology0.92602221
100MP0006054_spinal_hemorrhage0.91717307
101MP0002136_abnormal_kidney_physiology0.91446374
102MP0000427_abnormal_hair_cycle0.90382034
103MP0002272_abnormal_nervous_system0.88381577
104MP0002938_white_spotting0.88194286
105MP0000749_muscle_degeneration0.88186955
106MP0003718_maternal_effect0.87052682
107MP0003953_abnormal_hormone_level0.87045072
108MP0005395_other_phenotype0.86928934
109MP0001486_abnormal_startle_reflex0.86106327
110MP0000230_abnormal_systemic_arterial0.86035251
111MP0005195_abnormal_posterior_eye0.85265717
112MP0001188_hyperpigmentation0.85212687
113MP0003121_genomic_imprinting0.83674526
114MP0001544_abnormal_cardiovascular_syste0.83586510
115MP0005385_cardiovascular_system_phenoty0.83586510
116MP0005620_abnormal_muscle_contractility0.83176572
117MP0000462_abnormal_digestive_system0.83017866
118MP0008932_abnormal_embryonic_tissue0.82636542
119MP0002896_abnormal_bone_mineralization0.82614595
120MP0003119_abnormal_digestive_system0.81026840
121MP0005670_abnormal_white_adipose0.80957740
122MP0004145_abnormal_muscle_electrophysio0.80152498
123MP0009840_abnormal_foam_cell0.79634217
124MP0002095_abnormal_skin_pigmentation0.79625931
125MP0005174_abnormal_tail_pigmentation0.78347315
126MP0004957_abnormal_blastocyst_morpholog0.78236474
127MP0001905_abnormal_dopamine_level0.78090753
128MP0005248_abnormal_Harderian_gland0.76670296
129MP0002168_other_aberrant_phenotype0.76187015
130MP0003959_abnormal_lean_body0.75769427
131MP0000516_abnormal_urinary_system0.75305910
132MP0005367_renal/urinary_system_phenotyp0.75305910
133MP0009642_abnormal_blood_homeostasis0.75198472
134MP0000639_abnormal_adrenal_gland0.74711294
135MP0003941_abnormal_skin_development0.73807634
136MP0001929_abnormal_gametogenesis0.72950848
137MP0001986_abnormal_taste_sensitivity0.72525554
138MP0000653_abnormal_sex_gland0.71986254
139MP0003890_abnormal_embryonic-extraembry0.71868681
140MP0000003_abnormal_adipose_tissue0.71641933
141MP0002210_abnormal_sex_determination0.71523798
142MP0002160_abnormal_reproductive_system0.68996095
143MP0009672_abnormal_birth_weight0.68561356
144MP0003942_abnormal_urinary_system0.68207846
145MP0003656_abnormal_erythrocyte_physiolo0.68037738
146MP0001661_extended_life_span0.67839643
147MP0008961_abnormal_basal_metabolism0.67381357
148MP0005451_abnormal_body_composition0.65204365
149MP0005376_homeostasis/metabolism_phenot0.62151421
150MP0003191_abnormal_cellular_cholesterol0.62020060
151MP0001177_atelectasis0.61182245
152MP0000598_abnormal_liver_morphology0.60807195
153MP0006276_abnormal_autonomic_nervous0.60317576
154MP0000613_abnormal_salivary_gland0.59567308
155MP0002295_abnormal_pulmonary_circulatio0.58838621
156MP0000163_abnormal_cartilage_morphology0.57565186
157MP0006292_abnormal_olfactory_placode0.57247513
158MP0005266_abnormal_metabolism0.56880303
159MP0009053_abnormal_anal_canal0.53780240
160MP0002135_abnormal_kidney_morphology0.48842294
161MP0003879_abnormal_hair_cell0.48811565
162MP0006035_abnormal_mitochondrial_morpho0.48219929
163MP0005334_abnormal_fat_pad0.47450195
164MP0000681_abnormal_thyroid_gland0.46217052
165MP0010368_abnormal_lymphatic_system0.43475271
166MP0005645_abnormal_hypothalamus_physiol0.41258204
167MP0005257_abnormal_intraocular_pressure0.41049223
168MP0005389_reproductive_system_phenotype0.40657379
169MP0000631_abnormal_neuroendocrine_gland0.40061310

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.51478625
2Hypoglycemic coma (HP:0001325)4.80977760
3Ketoacidosis (HP:0001993)4.60616412
4Hypoglycemic seizures (HP:0002173)4.50818191
5Generalized aminoaciduria (HP:0002909)4.30328869
6Symptomatic seizures (HP:0011145)4.18594441
7Hyperinsulinemic hypoglycemia (HP:0000825)4.17634044
8Gout (HP:0001997)4.14579878
9Progressive macrocephaly (HP:0004481)4.01562434
10Ketosis (HP:0001946)3.99023314
11Hyperglycinuria (HP:0003108)3.96281642
12Mitochondrial inheritance (HP:0001427)3.92318184
13Increased hepatocellular lipid droplets (HP:0006565)3.67647881
14Intrahepatic cholestasis (HP:0001406)3.64787432
15Hyperactive renin-angiotensin system (HP:0000841)3.63518734
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.60732719
17Increased CSF lactate (HP:0002490)3.58476315
18Renal cortical cysts (HP:0000803)3.56123611
19Glycosuria (HP:0003076)3.40781275
20Abnormality of urine glucose concentration (HP:0011016)3.40781275
21Delayed CNS myelination (HP:0002188)3.38929325
22Abnormality of serine family amino acid metabolism (HP:0010894)3.36593121
23Abnormality of glycine metabolism (HP:0010895)3.36593121
24Hyperglycinemia (HP:0002154)3.33535106
25Acute encephalopathy (HP:0006846)3.30891675
26Proximal tubulopathy (HP:0000114)3.29071671
27Hypokalemic alkalosis (HP:0001949)3.22519347
28Abnormality of the intrinsic pathway (HP:0010989)3.22516212
29Abnormality of purine metabolism (HP:0004352)3.21539797
30Methylmalonic acidemia (HP:0002912)3.19480579
313-Methylglutaconic aciduria (HP:0003535)3.16292734
32Prolonged partial thromboplastin time (HP:0003645)3.15123455
33Hyperphosphaturia (HP:0003109)3.13602061
34Abnormality of the anterior horn cell (HP:0006802)3.13010633
35Degeneration of anterior horn cells (HP:0002398)3.13010633
36Enlarged kidneys (HP:0000105)3.12317381
37Abnormality of glutamine family amino acid metabolism (HP:0010902)3.09363727
38Hypomagnesemia (HP:0002917)3.06394780
39Hepatocellular necrosis (HP:0001404)3.02522356
40Abnormality of chloride homeostasis (HP:0011422)3.02174723
41Increased circulating renin level (HP:0000848)2.97925509
42Abnormality of fatty-acid metabolism (HP:0004359)2.97836610
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.96237712
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.96237712
45Medial flaring of the eyebrow (HP:0010747)2.96007678
46Alkalosis (HP:0001948)2.94497974
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.91370370
48Polyuria (HP:0000103)2.89941590
49Increased purine levels (HP:0004368)2.84926983
50Hyperuricemia (HP:0002149)2.84926983
51Hypobetalipoproteinemia (HP:0003563)2.83529818
52Abnormal urine output (HP:0012590)2.80626906
53Abnormality of nucleobase metabolism (HP:0010932)2.79280297
54Increased mean platelet volume (HP:0011877)2.78798967
55Metabolic alkalosis (HP:0200114)2.77580239
56Petechiae (HP:0000967)2.76324861
57Exertional dyspnea (HP:0002875)2.71668385
58Cerebral edema (HP:0002181)2.70625235
59Abnormal urine phosphate concentration (HP:0012599)2.70297831
60Increased intramyocellular lipid droplets (HP:0012240)2.70242902
61Abnormality of sulfur amino acid metabolism (HP:0004339)2.69094988
62Pancreatic cysts (HP:0001737)2.68569220
63Pancreatic fibrosis (HP:0100732)2.68050833
64Deep venous thrombosis (HP:0002625)2.67570226
65Xanthomatosis (HP:0000991)2.67073476
66Prolonged bleeding time (HP:0003010)2.66380275
67Hyperammonemia (HP:0001987)2.66369999
68Hyperglycemia (HP:0003074)2.65124643
69Congenital primary aphakia (HP:0007707)2.64363332
70Pancreatic islet-cell hyperplasia (HP:0004510)2.62153443
71Abnormality of the renal cortex (HP:0011035)2.59167868
72Late onset (HP:0003584)2.57789955
73Gait imbalance (HP:0002141)2.56422354
74Abnormality of the common coagulation pathway (HP:0010990)2.56129451
75Abnormality of magnesium homeostasis (HP:0004921)2.56104327
76Menorrhagia (HP:0000132)2.56034694
77Abnormality of renin-angiotensin system (HP:0000847)2.55698356
78Polydipsia (HP:0001959)2.54244096
79Abnormal drinking behavior (HP:0030082)2.54244096
80Lethargy (HP:0001254)2.54157926
81Abnormality of lateral ventricle (HP:0030047)2.52511571
82Abnormality of endocrine pancreas physiology (HP:0012093)2.50395962
83Abnormality of the pancreatic islet cells (HP:0006476)2.50395962
84Abnormality of renal excretion (HP:0011036)2.50179782
85Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49543144
86Abnormality of alanine metabolism (HP:0010916)2.49543144
87Hyperalaninemia (HP:0003348)2.49543144
88Abnormality of dicarboxylic acid metabolism (HP:0010995)2.47219833
89Dicarboxylic aciduria (HP:0003215)2.47219833
90Osteomalacia (HP:0002749)2.46921330
91Hypokalemia (HP:0002900)2.46731467
92Lactic acidosis (HP:0003128)2.45702901
93True hermaphroditism (HP:0010459)2.45684728
94Conjugated hyperbilirubinemia (HP:0002908)2.45327451
95Metabolic acidosis (HP:0001942)2.45134766
96Renal salt wasting (HP:0000127)2.41416026
97Abnormality of the labia minora (HP:0012880)2.41054402
98Acute necrotizing encephalopathy (HP:0006965)2.40697561
99Abnormal platelet volume (HP:0011876)2.39161889
100Nephrogenic diabetes insipidus (HP:0009806)2.38899102
101Abnormal mitochondria in muscle tissue (HP:0008316)2.37363992
102Respiratory failure (HP:0002878)2.36760918
103Methylmalonic aciduria (HP:0012120)2.33272216
104Increased serum lactate (HP:0002151)2.32794788
105Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.31025145
106Irritability (HP:0000737)2.29667961
107Tetany (HP:0001281)2.28897023
108Hepatoblastoma (HP:0002884)2.28895603
109Malnutrition (HP:0004395)2.27166834
110Hepatic necrosis (HP:0002605)2.26525008
111Congenital, generalized hypertrichosis (HP:0004540)2.24443991
112Genital tract atresia (HP:0001827)2.24350460
113Fat malabsorption (HP:0002630)2.24027775
114Decreased circulating renin level (HP:0003351)2.23898167
115Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.21823455
116Vomiting (HP:0002013)2.21381368
117Hyperaldosteronism (HP:0000859)2.19453223
118Renal tubular dysfunction (HP:0000124)2.19446535
119Molar tooth sign on MRI (HP:0002419)2.15819605
120Abnormality of midbrain morphology (HP:0002418)2.15819605
121Abnormality of calcium-phosphate metabolism (HP:0100530)2.15599958
122Increased muscle lipid content (HP:0009058)2.14219104
123Abnormal pancreas size (HP:0012094)2.13689631
124Hypothermia (HP:0002045)2.13107058
125Abnormality of methionine metabolism (HP:0010901)2.11786360
126Abnormality of vitamin B metabolism (HP:0004340)2.10995890
127Protuberant abdomen (HP:0001538)2.10733795
128Joint hemorrhage (HP:0005261)2.10604107
129Delayed epiphyseal ossification (HP:0002663)2.10118176
130Rickets (HP:0002748)2.09600905
131Vaginal atresia (HP:0000148)2.08787133
132Nausea (HP:0002018)2.07322251
133Abnormality of renal resorption (HP:0011038)2.06680049
134Abnormality of potassium homeostasis (HP:0011042)2.04406528
135Exercise intolerance (HP:0003546)2.03172805
136Acanthocytosis (HP:0001927)2.02762276
137CNS demyelination (HP:0007305)2.02087164
138Abnormality of serum amino acid levels (HP:0003112)2.00820354
139Hyperlipoproteinemia (HP:0010980)1.99119375
140Abnormal enzyme/coenzyme activity (HP:0012379)1.98829824
141Renal Fanconi syndrome (HP:0001994)1.98167153
142Hypophosphatemia (HP:0002148)1.97756853
143Short tibia (HP:0005736)1.96963307
144Renal tubular acidosis (HP:0001947)1.95488990
145Neuroendocrine neoplasm (HP:0100634)1.95487310
146Abnormality of pyrimidine metabolism (HP:0004353)1.94761297
147Dyschromatopsia (HP:0007641)1.93704240
148Pheochromocytoma (HP:0002666)1.93602351
149Lipid accumulation in hepatocytes (HP:0006561)1.92527368
150Abnormality of alkaline phosphatase activity (HP:0004379)1.92008455
151Abnormality of the vitamin B12 metabolism (HP:0004341)1.91733799
152Widely patent fontanelles and sutures (HP:0004492)1.91111938
153Tongue fasciculations (HP:0001308)1.90790368
154Optic disc pallor (HP:0000543)1.86624932
155Nephronophthisis (HP:0000090)1.85931527
156Aplasia/Hypoplasia of the tibia (HP:0005772)1.85501315
157Optic nerve hypoplasia (HP:0000609)1.83487703
158Leukodystrophy (HP:0002415)1.82493418
159Abnormal pupillary function (HP:0007686)1.81453478
160Purpura (HP:0000979)1.81435685
161Poikilocytosis (HP:0004447)1.80910520
162Poor coordination (HP:0002370)1.78713958
163Atrophy/Degeneration involving motor neurons (HP:0007373)1.75620851
164Abnormality of the heme biosynthetic pathway (HP:0010472)1.75524134
165Abnormality of the fovea (HP:0000493)1.75054053
166Aplasia/Hypoplasia of the tongue (HP:0010295)1.74195458
167Intestinal atresia (HP:0011100)1.73697683
168Abolished electroretinogram (ERG) (HP:0000550)1.73376184
169Male pseudohermaphroditism (HP:0000037)1.73316209
170X-linked dominant inheritance (HP:0001423)1.71635791
171Exercise-induced muscle cramps (HP:0003710)1.71005853
172Abnormality of homocysteine metabolism (HP:0010919)1.69978611
173Homocystinuria (HP:0002156)1.69978611
174Left ventricular hypertrophy (HP:0001712)1.69620918
175Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69567887
176Aplasia/Hypoplasia of the fovea (HP:0008060)1.69265128
177Hypoplasia of the fovea (HP:0007750)1.69265128
178Biliary tract neoplasm (HP:0100574)1.68579680

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.39029477
2WNK35.29086137
3WNK45.12239397
4BCKDK4.15525521
5TRIM283.88060577
6MST43.65397191
7PASK3.45946035
8STK38L3.25329850
9FRK3.19446479
10OXSR12.78334441
11EIF2AK12.69712667
12MAPK152.41765749
13MAP4K22.37653522
14AKT32.05844221
15TNIK2.05488882
16NUAK11.97705851
17FLT31.80052526
18ERBB41.66496568
19BRAF1.62555673
20BUB11.60375763
21MET1.59425738
22PLK21.48191564
23MAP3K121.41248662
24ABL21.38309776
25SIK31.37377438
26BMPR21.37159889
27PTK21.33559048
28MAP3K21.31551864
29VRK21.30533880
30WEE11.29623064
31TAOK31.29444640
32PIK3CG1.24759492
33PBK1.24756200
34LATS11.23948944
35CDK81.21532373
36DYRK21.21154271
37MAPK131.19913927
38ADRBK21.19670738
39CASK1.10862993
40ERN11.10539025
41LATS21.10241257
42BRSK21.09901116
43BMPR1B1.08924661
44GRK11.08004309
45STK391.07254028
46STK31.05789525
47PRKCI1.05643267
48MAP3K31.01265539
49SGK2231.00197336
50SGK4941.00197336
51BCR0.99848762
52PAK30.99723980
53HIPK20.97599877
54MKNK20.97461379
55CCNB10.93187322
56SIK10.91095994
57MKNK10.90490954
58PDK40.90065641
59PDK30.90065641
60EIF2AK30.86522770
61PLK30.86468215
62PNCK0.84764471
63TEC0.84558294
64SRPK10.83578302
65FER0.78264950
66MINK10.77677040
67NTRK10.77031660
68PHKG10.76854560
69PHKG20.76854560
70WNK10.76279794
71IRAK30.75954825
72CDC42BPA0.75088944
73TLK10.74861182
74IRAK10.74481105
75ARAF0.73982443
76GSK3A0.72276329
77EIF2AK20.71576285
78MAP2K40.71043769
79OBSCN0.71011635
80PTK2B0.70958897
81NTRK30.69737599
82MAP3K60.68627378
83GRK50.67907419
84AURKA0.64799936
85CAMKK20.64535182
86MAP2K20.63492904
87EPHA30.63117615
88ACVR1B0.62603175
89PINK10.62292621
90IRAK20.61006327
91MAP3K50.60406824
92DAPK30.59826091
93PRKCG0.57889838
94SGK20.56976017
95PRKG20.56957886
96PLK10.56653977
97STK160.55813839
98UHMK10.55066672
99TGFBR10.55007731
100PKN10.54472457
101MYLK0.54021258
102TAF10.54013284
103DYRK30.52936280
104MST1R0.52670202
105FGFR20.51992433
106STK40.51882171
107PRKCE0.49685404
108CDC70.47563752
109ILK0.47445590
110NME10.46346576
111FGFR40.46240494
112CAMK2A0.46014805
113PRKD30.45811469
114STK240.45040543
115MUSK0.44967259
116CSNK1G30.44619660
117PRKG10.44096799
118IGF1R0.43886055
119CSNK1G20.43421245
120ADRBK10.43222044
121PRKAA10.42277439
122VRK10.42216529
123MARK30.41809333
124MAP3K40.41763723
125ERBB30.41040926
126NEK10.40463650
127TTK0.39998751
128TSSK60.39947760
129PLK40.38742121
130MAP2K10.38523496
131PRKACA0.37326569
132EPHA20.36609880
133CSNK1G10.36589006
134PRKAA20.36394656
135MAP2K70.36352915
136CAMK2G0.34915097
137GRK70.34316544
138PDK20.33947269
139MAPK110.33757962
140DYRK1A0.33137383
141BMX0.33097023
142PIM20.32745686
143BRSK10.32646952
144PRKCZ0.32010315
145CSNK2A10.31116852
146TESK10.30865516
147PRKACG0.30788530
148TIE10.30591103
149CSNK1A1L0.30516650
150RPS6KA50.30362425
151NLK0.30341371
152CSNK1A10.30012338
153PRKACB0.29547648
154LMTK20.29281605
155ZAK0.28970127

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.10887292
2Sulfur metabolism_Homo sapiens_hsa009203.09799365
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.98061601
4Protein export_Homo sapiens_hsa030602.88205601
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.71824160
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.58840455
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.54493773
8Butanoate metabolism_Homo sapiens_hsa006502.51562693
9Tryptophan metabolism_Homo sapiens_hsa003802.49370767
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.29566911
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.27646645
12Propanoate metabolism_Homo sapiens_hsa006402.27595068
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.19474061
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.13734490
15Fatty acid degradation_Homo sapiens_hsa000712.10680221
16Selenocompound metabolism_Homo sapiens_hsa004502.06914215
17Peroxisome_Homo sapiens_hsa041462.06552616
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.00486830
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.99895077
20Mismatch repair_Homo sapiens_hsa034301.95278669
21Arginine biosynthesis_Homo sapiens_hsa002201.92416451
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.90586073
23Basal transcription factors_Homo sapiens_hsa030221.83430997
24Pyruvate metabolism_Homo sapiens_hsa006201.83102009
25Folate biosynthesis_Homo sapiens_hsa007901.77745385
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.75377352
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.66777412
28Homologous recombination_Homo sapiens_hsa034401.63129521
29Oxidative phosphorylation_Homo sapiens_hsa001901.61878869
30Ribosome_Homo sapiens_hsa030101.53844963
31Fatty acid metabolism_Homo sapiens_hsa012121.51997807
32Tyrosine metabolism_Homo sapiens_hsa003501.50317605
33Histidine metabolism_Homo sapiens_hsa003401.49564538
34Fanconi anemia pathway_Homo sapiens_hsa034601.47471910
35Phenylalanine metabolism_Homo sapiens_hsa003601.47192588
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.42215888
37beta-Alanine metabolism_Homo sapiens_hsa004101.40190106
38Nitrogen metabolism_Homo sapiens_hsa009101.39147560
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36345987
40Chemical carcinogenesis_Homo sapiens_hsa052041.35033993
41Fatty acid elongation_Homo sapiens_hsa000621.31427456
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.28546472
43Nucleotide excision repair_Homo sapiens_hsa034201.24174695
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.24130440
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22647657
46Phototransduction_Homo sapiens_hsa047441.22533371
47Steroid biosynthesis_Homo sapiens_hsa001001.20419737
48Starch and sucrose metabolism_Homo sapiens_hsa005001.20294801
49PPAR signaling pathway_Homo sapiens_hsa033201.18485859
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.18393694
51Carbon metabolism_Homo sapiens_hsa012001.17722585
52Complement and coagulation cascades_Homo sapiens_hsa046101.14537064
53Parkinsons disease_Homo sapiens_hsa050121.11881369
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06309693
55Biosynthesis of amino acids_Homo sapiens_hsa012301.05137424
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04124104
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.01755517
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01297342
59RNA degradation_Homo sapiens_hsa030181.00676352
60Arginine and proline metabolism_Homo sapiens_hsa003301.00493554
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98492762
62Purine metabolism_Homo sapiens_hsa002300.94118701
63Glutathione metabolism_Homo sapiens_hsa004800.93817007
64Bile secretion_Homo sapiens_hsa049760.93728892
65Retinol metabolism_Homo sapiens_hsa008300.89957479
66Vitamin digestion and absorption_Homo sapiens_hsa049770.89081247
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88808599
68Collecting duct acid secretion_Homo sapiens_hsa049660.87225161
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85969082
70Vibrio cholerae infection_Homo sapiens_hsa051100.80488589
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.79849636
72RNA transport_Homo sapiens_hsa030130.79174846
73Metabolic pathways_Homo sapiens_hsa011000.78872071
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78158875
75Lysine degradation_Homo sapiens_hsa003100.74813153
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74386378
77Huntingtons disease_Homo sapiens_hsa050160.71246106
78Sulfur relay system_Homo sapiens_hsa041220.71220889
79Alzheimers disease_Homo sapiens_hsa050100.70899912
80One carbon pool by folate_Homo sapiens_hsa006700.69164367
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66315340
82Non-homologous end-joining_Homo sapiens_hsa034500.64959666
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64749117
84ABC transporters_Homo sapiens_hsa020100.64153501
85Oocyte meiosis_Homo sapiens_hsa041140.64116158
86Olfactory transduction_Homo sapiens_hsa047400.63638451
87N-Glycan biosynthesis_Homo sapiens_hsa005100.61329708
88Mineral absorption_Homo sapiens_hsa049780.59702607
89Fructose and mannose metabolism_Homo sapiens_hsa000510.58459043
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57837342
91Fat digestion and absorption_Homo sapiens_hsa049750.57062871
92Other glycan degradation_Homo sapiens_hsa005110.56780302
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55401855
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54245816
95Galactose metabolism_Homo sapiens_hsa000520.53209894
96Serotonergic synapse_Homo sapiens_hsa047260.53037044
97Systemic lupus erythematosus_Homo sapiens_hsa053220.52687073
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51448487
99Insulin secretion_Homo sapiens_hsa049110.50072680
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48587863
101GABAergic synapse_Homo sapiens_hsa047270.47771985
102Ether lipid metabolism_Homo sapiens_hsa005650.44295260
103Alcoholism_Homo sapiens_hsa050340.43690532
104Spliceosome_Homo sapiens_hsa030400.42994876
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41769823
106Caffeine metabolism_Homo sapiens_hsa002320.40298880
107DNA replication_Homo sapiens_hsa030300.39887383
108Glycerolipid metabolism_Homo sapiens_hsa005610.39155438
109Cell cycle_Homo sapiens_hsa041100.38529584
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38463801
111Protein digestion and absorption_Homo sapiens_hsa049740.37994610
112Linoleic acid metabolism_Homo sapiens_hsa005910.36098026
113Nicotine addiction_Homo sapiens_hsa050330.34976406
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34640293
115p53 signaling pathway_Homo sapiens_hsa041150.33787833
116Vitamin B6 metabolism_Homo sapiens_hsa007500.32661109
117Pyrimidine metabolism_Homo sapiens_hsa002400.29459393
118RNA polymerase_Homo sapiens_hsa030200.28920493
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27488297
120Arachidonic acid metabolism_Homo sapiens_hsa005900.24008550
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23579363
122Glucagon signaling pathway_Homo sapiens_hsa049220.23059030
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.20926450
124Lysosome_Homo sapiens_hsa041420.20416494
125Thyroid hormone synthesis_Homo sapiens_hsa049180.18583903
126Pentose phosphate pathway_Homo sapiens_hsa000300.17359105
127Insulin resistance_Homo sapiens_hsa049310.16789147
128Cardiac muscle contraction_Homo sapiens_hsa042600.09084856
129Proteasome_Homo sapiens_hsa030500.08594102
130Regulation of autophagy_Homo sapiens_hsa041400.07416321
131Circadian rhythm_Homo sapiens_hsa047100.06664056
132Sphingolipid metabolism_Homo sapiens_hsa006000.06404864

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