LYRM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the mitochondrial leucine/tyrosine/arginine motif family of proteins. Proteins of this family are short polypeptides that contain a leucine/tyrosine/arginine motif near the N-terminus. This gene is widely expressed with high levels in omental adipose tissue of obese individuals. In adipose tissue, the protein is localized to the nucleus where it promotes preadipocyte proliferation and lowers the rate of apoptosis to regulate adipose tissue homeostasis. Overexpression of this gene in adipocytes causes abnormal mitochondrial morphology and mitochondrial dysfunction. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water-soluble vitamin biosynthetic process (GO:0042364)4.74606582
2behavioral response to nicotine (GO:0035095)4.57676040
3superoxide anion generation (GO:0042554)4.38273384
4protein neddylation (GO:0045116)4.01170199
5regulation of activation of Janus kinase activity (GO:0010533)4.00501011
6establishment of protein localization to mitochondrial membrane (GO:0090151)3.90234322
7positive regulation of cellular amide metabolic process (GO:0034250)3.83021273
8positive regulation of heat generation (GO:0031652)3.63785499
9response to pheromone (GO:0019236)3.61242599
10L-phenylalanine catabolic process (GO:0006559)3.60130422
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.60130422
12cellular ketone body metabolic process (GO:0046950)3.59996279
13DNA deamination (GO:0045006)3.59657587
14positive regulation of mitochondrial fission (GO:0090141)3.57636420
15regulation of fever generation (GO:0031620)3.56634059
16protein complex biogenesis (GO:0070271)3.53340424
17G-protein coupled receptor internalization (GO:0002031)3.41981550
18protein polyglutamylation (GO:0018095)3.36498568
19detection of molecule of bacterial origin (GO:0032490)3.33842928
20aromatic amino acid family catabolic process (GO:0009074)3.32767200
21cilium or flagellum-dependent cell motility (GO:0001539)3.29009746
22negative regulation of mast cell activation (GO:0033004)3.26769354
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.26756591
24NADH dehydrogenase complex assembly (GO:0010257)3.26756591
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.26756591
26neutrophil activation involved in immune response (GO:0002283)3.26211908
27ketone body metabolic process (GO:1902224)3.25773411
28platelet dense granule organization (GO:0060155)3.25759058
29regulation of cilium movement (GO:0003352)3.16897165
30negative regulation of appetite (GO:0032099)3.15588255
31negative regulation of response to food (GO:0032096)3.15588255
32axoneme assembly (GO:0035082)3.15302919
33regulation of T-helper 1 cell differentiation (GO:0045625)3.12515381
34positive regulation by symbiont of host defense response (GO:0052509)3.10333435
35modulation by symbiont of host defense response (GO:0052031)3.10333435
36modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.10333435
37modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.10333435
38positive regulation by organism of defense response of other organism involved in symbiotic interact3.10333435
39modulation by symbiont of host immune response (GO:0052553)3.10333435
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.09384802
41indolalkylamine catabolic process (GO:0046218)3.08444336
42tryptophan catabolic process (GO:0006569)3.08444336
43indole-containing compound catabolic process (GO:0042436)3.08444336
44detection of light stimulus involved in sensory perception (GO:0050962)3.05947728
45detection of light stimulus involved in visual perception (GO:0050908)3.05947728
46response to host immune response (GO:0052572)3.04364199
47response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.04364199
48epithelial cilium movement (GO:0003351)3.04306223
49mitochondrial respiratory chain complex assembly (GO:0033108)3.03181549
50regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.03098653
51S-adenosylmethionine metabolic process (GO:0046500)3.03022103
52pyrimidine nucleobase catabolic process (GO:0006208)3.00520916
53indolalkylamine metabolic process (GO:0006586)2.99514687
54L-phenylalanine metabolic process (GO:0006558)2.97172300
55erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.97172300
56regulation of heat generation (GO:0031650)2.96944228
57response to peptidoglycan (GO:0032494)2.94720168
58detection of other organism (GO:0098543)2.91144908
59preassembly of GPI anchor in ER membrane (GO:0016254)2.89795578
60microglial cell activation (GO:0001774)2.89689975
61kynurenine metabolic process (GO:0070189)2.89453236
62cellular biogenic amine catabolic process (GO:0042402)2.87289768
63amine catabolic process (GO:0009310)2.87289768
64piRNA metabolic process (GO:0034587)2.86332278
65synaptic transmission, cholinergic (GO:0007271)2.85627049
66positive regulation of interleukin-10 production (GO:0032733)2.84871746
67positive regulation of interleukin-1 beta secretion (GO:0050718)2.84733556
68male meiosis I (GO:0007141)2.83489766
69daunorubicin metabolic process (GO:0044597)2.82490922
70polyketide metabolic process (GO:0030638)2.82490922
71doxorubicin metabolic process (GO:0044598)2.82490922
72positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.81742046
73startle response (GO:0001964)2.81736223
74regulation of dendritic cell antigen processing and presentation (GO:0002604)2.78055097
75motile cilium assembly (GO:0044458)2.76923867
76regulation of glucokinase activity (GO:0033131)2.74893929
77regulation of hexokinase activity (GO:1903299)2.74893929
78neutrophil activation (GO:0042119)2.74136736
79negative regulation of systemic arterial blood pressure (GO:0003085)2.72239643
80GPI anchor metabolic process (GO:0006505)2.70693548
81negative regulation of synaptic transmission, GABAergic (GO:0032229)2.70344029
82nonmotile primary cilium assembly (GO:0035058)2.69273728
83sperm motility (GO:0030317)2.67967167
84positive regulation of prostaglandin secretion (GO:0032308)2.67157608
85cellular response to gamma radiation (GO:0071480)2.66083309
86dopamine transport (GO:0015872)2.65993632
87detection of external biotic stimulus (GO:0098581)2.65746322
88positive regulation of antigen processing and presentation (GO:0002579)2.65555241
89gamma-aminobutyric acid transport (GO:0015812)2.64963831
90modulation by virus of host process (GO:0019054)2.64694271
91protein-cofactor linkage (GO:0018065)2.63158457
92intraciliary transport (GO:0042073)2.62880431
93ubiquinone biosynthetic process (GO:0006744)2.62342031
94mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.62247215
95positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.61847643
96superoxide metabolic process (GO:0006801)2.61293899
97detection of bacterium (GO:0016045)2.61225409
98cellular response to interferon-beta (GO:0035458)2.60986453
99head development (GO:0060322)2.60312857
100centriole assembly (GO:0098534)2.58301238
101serotonin receptor signaling pathway (GO:0007210)2.57978145
102membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.57287782
103positive regulation of interleukin-1 secretion (GO:0050716)2.56478884
104seminiferous tubule development (GO:0072520)2.56378704
105granulocyte activation (GO:0036230)2.55604947
106nucleobase catabolic process (GO:0046113)2.54842584
107glyoxylate metabolic process (GO:0046487)2.54624007
108tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.54487213
109RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.54487213
110peroxisome fission (GO:0016559)2.54438847
111ubiquinone metabolic process (GO:0006743)2.54433922
112regulation of interleukin-1 beta secretion (GO:0050706)2.53667398
113natural killer cell activation involved in immune response (GO:0002323)2.53360403
114negative regulation of transcription regulatory region DNA binding (GO:2000678)2.50523016
115positive regulation of icosanoid secretion (GO:0032305)2.50446776
116regulation of prostaglandin secretion (GO:0032306)2.50100086
117multicellular organism reproduction (GO:0032504)2.49832836
118histamine secretion (GO:0001821)2.49721571
119L-fucose catabolic process (GO:0042355)2.49658656
120fucose catabolic process (GO:0019317)2.49658656
121L-fucose metabolic process (GO:0042354)2.49658656
122respiratory chain complex IV assembly (GO:0008535)2.49149007
123T-helper cell differentiation (GO:0042093)2.48715403
124CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.48715403
125anterograde synaptic vesicle transport (GO:0048490)2.47620035
126cytochrome complex assembly (GO:0017004)2.47393423
127aldehyde catabolic process (GO:0046185)2.46823449
128L-methionine biosynthetic process (GO:0071265)2.46602991
129amino acid salvage (GO:0043102)2.46602991
130L-methionine salvage (GO:0071267)2.46602991
131antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.46273186
132aromatic amino acid family metabolic process (GO:0009072)2.45792822
133regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.45113363
134energy homeostasis (GO:0097009)2.44831811
135adaptation of signaling pathway (GO:0023058)2.44440790
136response to host (GO:0075136)2.44014481
137response to host defenses (GO:0052200)2.44014481
138response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.44014481
139monocyte chemotaxis (GO:0002548)2.43782355
140negative regulation of homotypic cell-cell adhesion (GO:0034111)2.43692050
141xenobiotic catabolic process (GO:0042178)2.43638010
142phagosome maturation (GO:0090382)2.42457178
143mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.41714406
144regulation of mast cell activation (GO:0033003)2.41480563
145positive regulation of interleukin-12 production (GO:0032735)2.41248303
146regulation of platelet aggregation (GO:0090330)2.41216322
147negative regulation of telomere maintenance (GO:0032205)2.41115749
148mannosylation (GO:0097502)2.41102817
149neurofilament cytoskeleton organization (GO:0060052)2.40607434
150short-term memory (GO:0007614)2.40509512
151positive regulation of uterine smooth muscle contraction (GO:0070474)2.40326027
152chaperone-mediated protein transport (GO:0072321)2.39638127
153axonemal dynein complex assembly (GO:0070286)2.39289371
154developmental pigmentation (GO:0048066)2.39135575
155L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.38369378
156tryptophan metabolic process (GO:0006568)2.37329949
157regulation of memory T cell differentiation (GO:0043380)2.36800795
158positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.36730740
159cilium movement (GO:0003341)2.36545756
160detection of biotic stimulus (GO:0009595)2.36409642
161vitamin biosynthetic process (GO:0009110)2.35185596
162urinary tract smooth muscle contraction (GO:0014848)2.34636084
163somite development (GO:0061053)2.34462416
164cilium organization (GO:0044782)2.34005149
165meiosis I (GO:0007127)2.33976683
166C4-dicarboxylate transport (GO:0015740)2.33712444
167inositol phosphate catabolic process (GO:0071545)2.33252112
168positive regulation of action potential (GO:0045760)2.33085825
169negative regulation of viral genome replication (GO:0045071)2.32504992
170positive regulation of type 2 immune response (GO:0002830)2.32247539
171response to nitrosative stress (GO:0051409)2.31843562
172regulation of sequestering of triglyceride (GO:0010889)2.31730413
173negative regulation of interleukin-17 production (GO:0032700)2.31537969
174neuronal action potential propagation (GO:0019227)2.31203634
175modulation by symbiont of host cellular process (GO:0044068)2.31148115
176indole-containing compound metabolic process (GO:0042430)2.30591138
177positive regulation of alpha-beta T cell proliferation (GO:0046641)2.30373093
178parturition (GO:0007567)2.30084838
179regulation of mast cell activation involved in immune response (GO:0033006)2.29698234
180dendritic cell chemotaxis (GO:0002407)2.29475698
181photoreceptor cell maintenance (GO:0045494)2.29258729
182magnesium ion transport (GO:0015693)2.28664086
183regulation of mast cell degranulation (GO:0043304)2.28399087
184positive regulation of protein homodimerization activity (GO:0090073)2.26280941
185righting reflex (GO:0060013)2.26231176
186regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.26178395
187positive regulation of lymphocyte migration (GO:2000403)2.26083096
188positive regulation of monocyte chemotaxis (GO:0090026)2.25672517
189positive regulation of T cell migration (GO:2000406)2.25234449
190regulation of mitotic spindle checkpoint (GO:1903504)2.24726657
191regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.24726657
192acrosome reaction (GO:0007340)2.24021747
193eosinophil chemotaxis (GO:0048245)2.23560335
194interferon-gamma production (GO:0032609)2.23469236
195auditory receptor cell stereocilium organization (GO:0060088)2.21744353
196positive regulation of cAMP-mediated signaling (GO:0043950)2.21483079
197protein localization to cilium (GO:0061512)2.20721192
198regulation of timing of cell differentiation (GO:0048505)2.18959908
199purinergic nucleotide receptor signaling pathway (GO:0035590)2.18686881

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.78864321
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.17432273
3ZNF274_21170338_ChIP-Seq_K562_Hela3.00737546
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.95533120
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.91267254
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.82616938
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.78150835
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.77682157
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.72387342
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.67384596
11EZH2_22144423_ChIP-Seq_EOC_Human2.45257119
12TAF15_26573619_Chip-Seq_HEK293_Human2.44433120
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37092661
14SUZ12_27294783_Chip-Seq_NPCs_Mouse2.30002049
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.21976937
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20314316
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.18512195
18NFE2_27457419_Chip-Seq_LIVER_Mouse2.18467778
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.12474492
20PCGF2_27294783_Chip-Seq_NPCs_Mouse2.06793754
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.99072644
22NANOG_18555785_Chip-Seq_ESCs_Mouse1.95802554
23TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.93068297
24P300_19829295_ChIP-Seq_ESCs_Human1.92943948
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92388361
26EZH2_27294783_Chip-Seq_NPCs_Mouse1.91440782
27IRF1_19129219_ChIP-ChIP_H3396_Human1.91265217
28EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.89495032
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.88989406
30P53_22387025_ChIP-Seq_ESCs_Mouse1.87320679
31STAT3_18555785_Chip-Seq_ESCs_Mouse1.85896305
32SUZ12_18555785_Chip-Seq_ESCs_Mouse1.85134384
33E2F1_18555785_Chip-Seq_ESCs_Mouse1.85091456
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.82872401
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82822932
36IGF1R_20145208_ChIP-Seq_DFB_Human1.82262015
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80748457
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76197426
39VDR_22108803_ChIP-Seq_LS180_Human1.74952910
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74561615
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73755062
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73557050
43CMYC_18555785_Chip-Seq_ESCs_Mouse1.71776410
44NMYC_18555785_Chip-Seq_ESCs_Mouse1.70804433
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.70769024
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.67893527
47EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.66314976
48RUNX1_27457419_Chip-Seq_LIVER_Mouse1.62728270
49P300_18555785_Chip-Seq_ESCs_Mouse1.62139227
50ER_23166858_ChIP-Seq_MCF-7_Human1.61409841
51SMAD4_21799915_ChIP-Seq_A2780_Human1.60148155
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.60112052
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.59653123
54SOX2_18555785_Chip-Seq_ESCs_Mouse1.58661991
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58023554
56OCT4_18555785_Chip-Seq_ESCs_Mouse1.55265750
57PU1_27457419_Chip-Seq_LIVER_Mouse1.54494704
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.51984695
59ZFX_18555785_Chip-Seq_ESCs_Mouse1.49238018
60CBP_20019798_ChIP-Seq_JUKART_Human1.48594788
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48594788
62FUS_26573619_Chip-Seq_HEK293_Human1.48409473
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44950501
64RNF2_27304074_Chip-Seq_NSC_Mouse1.43981864
65SOX2_19829295_ChIP-Seq_ESCs_Human1.43452690
66NANOG_19829295_ChIP-Seq_ESCs_Human1.43452690
67Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42943063
68EWS_26573619_Chip-Seq_HEK293_Human1.42820866
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42394350
70KLF4_18555785_Chip-Seq_ESCs_Mouse1.42135250
71ESRRB_18555785_Chip-Seq_ESCs_Mouse1.41333338
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.40435869
73SMAD1_18555785_Chip-Seq_ESCs_Mouse1.40060871
74BCAT_22108803_ChIP-Seq_LS180_Human1.40050059
75CTCF_18555785_Chip-Seq_ESCs_Mouse1.39021113
76TP53_22573176_ChIP-Seq_HFKS_Human1.38505878
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.38284104
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35548576
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35518452
80* TAL1_26923725_Chip-Seq_HPCs_Mouse1.35436583
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35014206
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.34381717
83FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34381717
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.33384334
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33362612
86* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33298503
87OCT4_21477851_ChIP-Seq_ESCs_Mouse1.33229304
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32566611
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31574305
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30929966
91EED_16625203_ChIP-ChIP_MESCs_Mouse1.30695306
92ELK1_19687146_ChIP-ChIP_HELA_Human1.29816397
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26833368
94SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.25947786
95LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25365786
96NCOR_22424771_ChIP-Seq_293T_Human1.24599650
97ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24543209
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23045545
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.22719410
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.22538199
101SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21592579
102AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21341254
103HTT_18923047_ChIP-ChIP_STHdh_Human1.21260118
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20922022
105STAT3_23295773_ChIP-Seq_U87_Human1.20833137
106IRF8_27001747_Chip-Seq_BMDM_Mouse1.20777773
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20367857
108REST_21632747_ChIP-Seq_MESCs_Mouse1.18938514
109CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17277576
110KDM2B_26808549_Chip-Seq_REH_Human1.16933054
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16915828
112* TCF4_23295773_ChIP-Seq_U87_Human1.16262811
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16090282
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16090282
115SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16082786
116JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15830909
117VDR_23849224_ChIP-Seq_CD4+_Human1.15130169
118TCF4_22108803_ChIP-Seq_LS180_Human1.14435892
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13985314
120FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13731062
121AR_25329375_ChIP-Seq_VCAP_Human1.12774395
122PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12475805
123MYC_18940864_ChIP-ChIP_HL60_Human1.12101042
124AR_20517297_ChIP-Seq_VCAP_Human1.11146050
125CDX2_22108803_ChIP-Seq_LS180_Human1.09734569
126RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09506834
127GATA3_21878914_ChIP-Seq_MCF-7_Human1.09493594
128PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08740696
129JUN_21703547_ChIP-Seq_K562_Human1.07333856
130STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07128153
131PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06167310
132FLI1_21867929_ChIP-Seq_TH2_Mouse1.05497639
133RUNX2_22187159_ChIP-Seq_PCA_Human1.05351379
134FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05141639
135TP53_18474530_ChIP-ChIP_U2OS_Human1.05077631
136KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03980929
137PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03854152
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01630760
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01540337
140REST_18959480_ChIP-ChIP_MESCs_Mouse1.01337538
141SMAD4_21741376_ChIP-Seq_EPCs_Human1.01216519
142* SRF_21415370_ChIP-Seq_HL-1_Mouse1.00861845
143SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00573966
144RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00462578
145EZH2_27304074_Chip-Seq_ESCs_Mouse1.00364608
146NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00045558

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.53685398
2MP0001188_hyperpigmentation3.17942078
3MP0000566_synostosis2.97346695
4MP0002148_abnormal_hypersensitivity_rea2.90359056
5MP0001835_abnormal_antigen_presentation2.84642801
6MP0006292_abnormal_olfactory_placode2.78823642
7MP0002277_abnormal_respiratory_mucosa2.60821253
8MP0005171_absent_coat_pigmentation2.59566491
9MP0001986_abnormal_taste_sensitivity2.37935830
10MP0003122_maternal_imprinting2.31993508
11MP0009785_altered_susceptibility_to2.22372102
12MP0000015_abnormal_ear_pigmentation2.19637835
13MP0005671_abnormal_response_to2.17588973
14MP0005084_abnormal_gallbladder_morpholo2.13190701
15MP0001984_abnormal_olfaction2.12015099
16MP0003136_yellow_coat_color2.11507765
17MP0003724_increased_susceptibility_to2.03166771
18MP0002160_abnormal_reproductive_system1.99176449
19MP0002102_abnormal_ear_morphology1.95430760
20MP0003011_delayed_dark_adaptation1.94882844
21MP0002163_abnormal_gland_morphology1.94201302
22MP0005645_abnormal_hypothalamus_physiol1.93272675
23MP0010386_abnormal_urinary_bladder1.92157198
24MP0003880_abnormal_central_pattern1.87085605
25MP0008260_abnormal_autophagy1.87053881
26MP0009697_abnormal_copulation1.86843966
27MP0005646_abnormal_pituitary_gland1.83847639
28MP0008875_abnormal_xenobiotic_pharmacok1.81324560
29MP0002419_abnormal_innate_immunity1.79516935
30MP0002876_abnormal_thyroid_physiology1.77941615
31MP0004885_abnormal_endolymph1.77277091
32MP0003787_abnormal_imprinting1.73663012
33MP0000569_abnormal_digit_pigmentation1.72304780
34MP0009764_decreased_sensitivity_to1.68390820
35MP0002139_abnormal_hepatobiliary_system1.67893153
36MP0005389_reproductive_system_phenotype1.67603235
37MP0001790_abnormal_immune_system1.64111276
38MP0005387_immune_system_phenotype1.64111276
39MP0009046_muscle_twitch1.63853269
40MP0002735_abnormal_chemical_nociception1.63179322
41MP0001486_abnormal_startle_reflex1.62444436
42MP0002638_abnormal_pupillary_reflex1.62068913
43MP0008872_abnormal_physiological_respon1.61492962
44MP0005000_abnormal_immune_tolerance1.60919182
45MP0006072_abnormal_retinal_apoptosis1.59554746
46MP0003121_genomic_imprinting1.59032331
47MP0008877_abnormal_DNA_methylation1.58652093
48MP0001346_abnormal_lacrimal_gland1.56125771
49MP0001501_abnormal_sleep_pattern1.53207741
50MP0008789_abnormal_olfactory_epithelium1.47042799
51MP0005410_abnormal_fertilization1.46670649
52MP0008058_abnormal_DNA_repair1.46511157
53MP0003941_abnormal_skin_development1.45131421
54MP0005025_abnormal_response_to1.44489435
55MP0002723_abnormal_immune_serum1.43136963
56MP0005379_endocrine/exocrine_gland_phen1.43066543
57MP0002452_abnormal_antigen_presenting1.41466642
58MP0004510_myositis1.41044298
59MP0006036_abnormal_mitochondrial_physio1.37050099
60MP0001485_abnormal_pinna_reflex1.35693698
61MP0005253_abnormal_eye_physiology1.35369460
62MP0000372_irregular_coat_pigmentation1.35231174
63MP0001919_abnormal_reproductive_system1.34117613
64MP0002736_abnormal_nociception_after1.34093458
65MP0005085_abnormal_gallbladder_physiolo1.33898693
66MP0005310_abnormal_salivary_gland1.32859520
67MP0008057_abnormal_DNA_replication1.32340693
68MP0002653_abnormal_ependyma_morphology1.32334013
69MP0002138_abnormal_hepatobiliary_system1.31673146
70MP0003252_abnormal_bile_duct1.31291439
71MP0005365_abnormal_bile_salt1.29160156
72MP0001800_abnormal_humoral_immune1.26825631
73MP0002733_abnormal_thermal_nociception1.26361778
74MP0004782_abnormal_surfactant_physiolog1.25435074
75MP0010329_abnormal_lipoprotein_level1.24606802
76MP0005409_darkened_coat_color1.23937282
77MP0001970_abnormal_pain_threshold1.23364739
78MP0001764_abnormal_homeostasis1.22711206
79MP0001819_abnormal_immune_cell1.22621841
80MP0006082_CNS_inflammation1.21766727
81MP0005332_abnormal_amino_acid1.21054664
82MP0006276_abnormal_autonomic_nervous1.18974608
83MP0003186_abnormal_redox_activity1.18872143
84MP0004215_abnormal_myocardial_fiber1.18854553
85MP0002420_abnormal_adaptive_immunity1.18397453
86MP0000631_abnormal_neuroendocrine_gland1.16915141
87MP0004381_abnormal_hair_follicle1.13287497
88MP0005499_abnormal_olfactory_system1.12986577
89MP0005394_taste/olfaction_phenotype1.12986577
90MP0003828_pulmonary_edema1.11407713
91MP0005174_abnormal_tail_pigmentation1.09851135
92MP0001968_abnormal_touch/_nociception1.08221602
93MP0005257_abnormal_intraocular_pressure1.04279898
94MP0009745_abnormal_behavioral_response1.03404471
95MP0005451_abnormal_body_composition1.01991233
96MP0004742_abnormal_vestibular_system0.99959892
97MP0003567_abnormal_fetal_cardiomyocyte0.99899533
98MP0002009_preneoplasia0.98601691
99MP0003879_abnormal_hair_cell0.98463257
100MP0002557_abnormal_social/conspecific_i0.98426504
101MP0005075_abnormal_melanosome_morpholog0.97805281
102MP0001502_abnormal_circadian_rhythm0.97418502
103MP0004130_abnormal_muscle_cell0.96511958
104MP0003950_abnormal_plasma_membrane0.96441633
105MP0003698_abnormal_male_reproductive0.96369069
106MP0005386_behavior/neurological_phenoty0.96290878
107MP0004924_abnormal_behavior0.96290878
108MP0002998_abnormal_bone_remodeling0.95344505
109MP0004142_abnormal_muscle_tone0.94961720
110MP0002572_abnormal_emotion/affect_behav0.94514413
111MP0006035_abnormal_mitochondrial_morpho0.94281113
112MP0003436_decreased_susceptibility_to0.93484713
113MP0002928_abnormal_bile_duct0.92181241
114MP0002067_abnormal_sensory_capabilities0.91874466
115MP0005535_abnormal_body_temperature0.91580195
116MP0005670_abnormal_white_adipose0.90595407
117MP0000427_abnormal_hair_cycle0.89192591
118MP0000230_abnormal_systemic_arterial0.88961644
119MP0004147_increased_porphyrin_level0.88752694
120MP0008775_abnormal_heart_ventricle0.88719418
121MP0001529_abnormal_vocalization0.86547943
122MP0002938_white_spotting0.86213532
123MP0001929_abnormal_gametogenesis0.86213016
124MP0000681_abnormal_thyroid_gland0.85026434
125MP0003635_abnormal_synaptic_transmissio0.84412332
126MP0005195_abnormal_posterior_eye0.83713700
127MP0002693_abnormal_pancreas_physiology0.83574726
128MP0004145_abnormal_muscle_electrophysio0.83322292
129MP0001905_abnormal_dopamine_level0.82835796
130MP0000049_abnormal_middle_ear0.82814485
131MP0003183_abnormal_peptide_metabolism0.82741366
132MP0004043_abnormal_pH_regulation0.82717731
133MP0003195_calcinosis0.82020392
134MP0002095_abnormal_skin_pigmentation0.82015738
135MP0005636_abnormal_mineral_homeostasis0.80855769
136MP0001963_abnormal_hearing_physiology0.80175661
137MP0002064_seizures0.79621033
138MP0002272_abnormal_nervous_system0.78868580
139MP0001944_abnormal_pancreas_morphology0.78384176
140MP0000026_abnormal_inner_ear0.77921580
141MP0005551_abnormal_eye_electrophysiolog0.77495836
142MP0008007_abnormal_cellular_replicative0.77404021
143MP0008995_early_reproductive_senescence0.76903696
144MP0002909_abnormal_adrenal_gland0.75820628
145MP0002734_abnormal_mechanical_nocicepti0.75580765
146MP0002063_abnormal_learning/memory/cond0.74909335
147MP0000716_abnormal_immune_system0.74501941
148MP0002405_respiratory_system_inflammati0.73926065
149MP0002132_abnormal_respiratory_system0.73128150
150MP0004484_altered_response_of0.70495349
151MP0003646_muscle_fatigue0.70270503
152MP0005647_abnormal_sex_gland0.69723776
153MP0001440_abnormal_grooming_behavior0.69658524
154MP0000685_abnormal_immune_system0.69470380
155MP0001845_abnormal_inflammatory_respons0.68710006
156MP0002396_abnormal_hematopoietic_system0.67803197

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.13094226
2Absent/shortened dynein arms (HP:0200106)4.01946580
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.01946580
4Febrile seizures (HP:0002373)4.00519451
5Prostate neoplasm (HP:0100787)3.82980337
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.60365894
7Chromsome breakage (HP:0040012)3.58599803
8Molar tooth sign on MRI (HP:0002419)3.55261602
9Abnormality of midbrain morphology (HP:0002418)3.55261602
10Abnormal respiratory epithelium morphology (HP:0012253)3.43386048
11Abnormal respiratory motile cilium morphology (HP:0005938)3.43386048
12Abnormal hair whorl (HP:0010721)3.40085032
13Abnormal ciliary motility (HP:0012262)3.37802118
14Retrobulbar optic neuritis (HP:0100654)3.19728344
15Optic neuritis (HP:0100653)3.19728344
16Abnormality of incisor morphology (HP:0011063)3.16733277
17Acute necrotizing encephalopathy (HP:0006965)3.13715544
18Recurrent abscess formation (HP:0002722)3.05751480
19Focal motor seizures (HP:0011153)3.00413273
20Progressive macrocephaly (HP:0004481)2.96944805
21Abnormal respiratory motile cilium physiology (HP:0012261)2.96681457
22Methylmalonic acidemia (HP:0002912)2.91963781
23Mitochondrial inheritance (HP:0001427)2.76387985
24Abnormal mitochondria in muscle tissue (HP:0008316)2.73980400
25Acute encephalopathy (HP:0006846)2.73100027
26True hermaphroditism (HP:0010459)2.67608052
27Mediastinal lymphadenopathy (HP:0100721)2.65054528
28Increased CSF lactate (HP:0002490)2.63285230
29Eczematoid dermatitis (HP:0000976)2.62384243
30Abolished electroretinogram (ERG) (HP:0000550)2.62215296
31Patchy hypopigmentation of hair (HP:0011365)2.60203254
32Hyperglycinemia (HP:0002154)2.59299499
33Methylmalonic aciduria (HP:0012120)2.56779841
34White forelock (HP:0002211)2.56440525
35Ketosis (HP:0001946)2.52981412
36Chronic hepatic failure (HP:0100626)2.52511739
37Recurrent bacterial skin infections (HP:0005406)2.50722376
38Recurrent pneumonia (HP:0006532)2.47318633
39Hepatic necrosis (HP:0002605)2.46836776
40Medial flaring of the eyebrow (HP:0010747)2.45015066
41Parakeratosis (HP:0001036)2.44995428
42Aplasia cutis congenita (HP:0001057)2.44068449
43Abnormality of the renal collecting system (HP:0004742)2.41714857
44Pancreatic fibrosis (HP:0100732)2.38689053
45Congenital sensorineural hearing impairment (HP:0008527)2.38576457
46Increased IgM level (HP:0003496)2.37550107
47Renal cortical cysts (HP:0000803)2.35121488
48Ketoacidosis (HP:0001993)2.34019814
49Septo-optic dysplasia (HP:0100842)2.33281869
50Abnormality of aromatic amino acid family metabolism (HP:0004338)2.32605841
51Hepatocellular necrosis (HP:0001404)2.32150762
52Conical tooth (HP:0000698)2.30769838
53Tubular atrophy (HP:0000092)2.30324607
54Fair hair (HP:0002286)2.30096405
55Submucous cleft hard palate (HP:0000176)2.29930189
56Abnormal rod and cone electroretinograms (HP:0008323)2.28730617
57Abnormality of the nasal septum (HP:0000419)2.26928240
58Renal Fanconi syndrome (HP:0001994)2.26758717
59Abnormality of the labia minora (HP:0012880)2.26319670
60Duplicated collecting system (HP:0000081)2.25817807
61Polyphagia (HP:0002591)2.25625295
62Abnormal drinking behavior (HP:0030082)2.23280909
63Polydipsia (HP:0001959)2.23280909
64Alveolar cell carcinoma (HP:0006519)2.21563515
65Orchitis (HP:0100796)2.20467529
66Lipid accumulation in hepatocytes (HP:0006561)2.20172868
67Abnormality of urine glucose concentration (HP:0011016)2.19538693
68Glycosuria (HP:0003076)2.19538693
69Stomatitis (HP:0010280)2.19146890
70Increased hepatocellular lipid droplets (HP:0006565)2.16759079
71Hypothermia (HP:0002045)2.16395220
72Decreased central vision (HP:0007663)2.15523427
73Nephronophthisis (HP:0000090)2.15507380
74Recurrent cutaneous fungal infections (HP:0011370)2.15156920
75Chronic mucocutaneous candidiasis (HP:0002728)2.15156920
76Genital tract atresia (HP:0001827)2.13197173
77Nephrogenic diabetes insipidus (HP:0009806)2.12939588
78Hypoplasia of the fovea (HP:0007750)2.12408431
79Aplasia/Hypoplasia of the fovea (HP:0008060)2.12408431
80Epileptic encephalopathy (HP:0200134)2.11306595
81Ectopic kidney (HP:0000086)2.10361554
82Rhinitis (HP:0012384)2.08667187
83Chronic obstructive pulmonary disease (HP:0006510)2.07004564
84Obstructive lung disease (HP:0006536)2.07004564
85Tubulointerstitial nephritis (HP:0001970)2.05371264
86Clubbing of toes (HP:0100760)2.03109864
87Generalized hypopigmentation of hair (HP:0011358)2.02692868
883-Methylglutaconic aciduria (HP:0003535)2.01831113
89Vaginal atresia (HP:0000148)2.00689504
90Hyperlipoproteinemia (HP:0010980)1.99317532
91Pendular nystagmus (HP:0012043)1.98478922
92Pancreatic cysts (HP:0001737)1.98242773
93Abnormality of the prostate (HP:0008775)1.97607320
94Lip pit (HP:0100267)1.97195202
95Abnormality of renal resorption (HP:0011038)1.97085673
96Adrenal hypoplasia (HP:0000835)1.96542370
97Cerebral edema (HP:0002181)1.96505226
98Congenital hepatic fibrosis (HP:0002612)1.95900384
99Abnormality of macrophages (HP:0004311)1.94951016
100Abnormality of alanine metabolism (HP:0010916)1.93901856
101Hyperalaninemia (HP:0003348)1.93901856
102Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93901856
103Recurrent gram-negative bacterial infections (HP:0005420)1.92732500
104Type 2 muscle fiber atrophy (HP:0003554)1.92471051
105Recurrent sinusitis (HP:0011108)1.92419534
106Abnormality of the renal medulla (HP:0100957)1.92414431
107Congenital stationary night blindness (HP:0007642)1.92298036
108Congenital primary aphakia (HP:0007707)1.91937025
109Optic disc pallor (HP:0000543)1.91925306
110Polyuria (HP:0000103)1.91373999
111Male pseudohermaphroditism (HP:0000037)1.90347331
112Neoplasm of the tracheobronchial system (HP:0100552)1.90299106
113Median cleft lip (HP:0000161)1.89571945
114Gonadotropin excess (HP:0000837)1.89497707
115Attenuation of retinal blood vessels (HP:0007843)1.89076809
116Epidermoid cyst (HP:0200040)1.88225426
117Myositis (HP:0100614)1.88055946
118Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86696592
119Aplasia/Hypoplasia of the tongue (HP:0010295)1.86370394
120Lethargy (HP:0001254)1.86195112
121Cystic liver disease (HP:0006706)1.86099218
122Optic nerve hypoplasia (HP:0000609)1.85838249
123Chronic diarrhea (HP:0002028)1.85496039
124Lactic acidosis (HP:0003128)1.85004298
125Aplasia/Hypoplasia of the uvula (HP:0010293)1.84967962
126Increased serum lactate (HP:0002151)1.82129525
127Gait imbalance (HP:0002141)1.81288522
128Progressive inability to walk (HP:0002505)1.80808726
129Cheilitis (HP:0100825)1.80391424
130Abnormal biliary tract physiology (HP:0012439)1.79427611
131Bile duct proliferation (HP:0001408)1.79427611
132Abnormality of serine family amino acid metabolism (HP:0010894)1.78568239
133Abnormality of glycine metabolism (HP:0010895)1.78568239
134Sclerocornea (HP:0000647)1.77862833
135Asplenia (HP:0001746)1.77833125
136Vasculitis (HP:0002633)1.77318750
137Generalized aminoaciduria (HP:0002909)1.76644292
138Recurrent lower respiratory tract infections (HP:0002783)1.74973617
139Poor coordination (HP:0002370)1.74816756
140Specific learning disability (HP:0001328)1.74764672
141Lissencephaly (HP:0001339)1.73390647
142Hypergonadotropic hypogonadism (HP:0000815)1.72473186
143Metaphyseal dysplasia (HP:0100255)1.71936109
144Hyperinsulinemic hypoglycemia (HP:0000825)1.71689358
145Anomalous pulmonary venous return (HP:0010772)1.71586765
146Atonic seizures (HP:0010819)1.71456634
147Abnormality of DNA repair (HP:0003254)1.71259347
148Abnormality of the preputium (HP:0100587)1.71152614
149Prolonged neonatal jaundice (HP:0006579)1.70849270
150Recurrent skin infections (HP:0001581)1.70730346
151Meckel diverticulum (HP:0002245)1.70712759
152Postaxial hand polydactyly (HP:0001162)1.70685747
153Keratoconjunctivitis sicca (HP:0001097)1.70651523
154Protruding tongue (HP:0010808)1.70591541
155Abnormality of the renal cortex (HP:0011035)1.70564806
156Agitation (HP:0000713)1.70090347
157Aplasia/Hypoplasia of the spleen (HP:0010451)1.69556834
158Postaxial foot polydactyly (HP:0001830)1.69479182
159Aplasia/Hypoplasia of the tibia (HP:0005772)1.69215475
160Narrow forehead (HP:0000341)1.69092754
161Dry hair (HP:0011359)1.68620599
162Decreased activity of mitochondrial respiratory chain (HP:0008972)1.68289635
163Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.68289635
164Preaxial hand polydactyly (HP:0001177)1.68023613
165Poor suck (HP:0002033)1.67364571
166Abnormality of the incisor (HP:0000676)1.67087234
167Pachygyria (HP:0001302)1.66184511
168Abnormal urine output (HP:0012590)1.66159107

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.45401879
2MAP3K143.12131940
3MAP4K22.97851692
4IRAK32.91144841
5SIK32.76510452
6ZAK2.74404962
7TXK2.69841645
8WNK32.64701420
9INSRR2.53504440
10TRIM282.39770570
11BMPR22.27641866
12RIPK42.19570467
13EIF2AK22.11746816
14BMPR1B2.02028618
15STK161.99626307
16PRPF4B1.93407467
17IRAK41.92978950
18WNK41.89509591
19GRK71.87926806
20TAOK31.81278264
21MAP2K71.77996332
22AKT31.71619618
23ADRBK21.70072783
24TNIK1.63027532
25STK38L1.60794233
26YES11.58383671
27DYRK21.55293960
28MAP3K41.54678703
29STK391.51115778
30NUAK11.48335315
31MUSK1.46917808
32PLK41.43916793
33CSNK1G21.38746447
34IKBKB1.38317108
35ACVR1B1.35753818
36BCKDK1.31401213
37MAP3K121.29607184
38SGK21.27966112
39CSNK1G31.27081575
40IKBKE1.24270442
41CDK31.24188731
42PIM21.22017232
43PAK31.20282292
44PHKG21.19885657
45PHKG11.19885657
46MARK11.18256134
47CSNK1G11.18249839
48PBK1.17614824
49NEK61.16801365
50ERBB31.16702884
51JAK31.14468346
52OXSR11.12215592
53TEC1.11473557
54PLK21.10094367
55CDK81.06968184
56MAPKAPK31.04673985
57NTRK31.04617040
58MST41.04580990
59IRAK11.04160596
60IRAK21.02155041
61STK241.01530560
62CAMKK21.00320386
63PRKCG0.99876320
64CSNK1A1L0.98866002
65DYRK30.97891759
66CHUK0.95996813
67MAPK130.95946602
68PINK10.94871058
69EIF2AK10.94635284
70BLK0.94118331
71DAPK20.92187334
72MINK10.91265144
73TRPM70.88330375
74BCR0.84607304
75MKNK20.83643208
76PLK30.83272108
77PDK20.81530751
78NLK0.81094849
79MARK30.80781120
80PRKCE0.79464183
81SRPK10.79226870
82FRK0.74729272
83SGK4940.74198856
84SGK2230.74198856
85MAP3K130.73490189
86PTK2B0.73429911
87VRK10.72474211
88TNK20.72075220
89GRK10.71322843
90TBK10.70656021
91OBSCN0.70460908
92PNCK0.70417361
93CLK10.67494581
94JAK10.67345461
95EPHA40.65941424
96LYN0.64411127
97PKN10.64214441
98CDK120.62269878
99NEK10.60860394
100SYK0.59603962
101KIT0.59566947
102ERBB40.56224074
103PIM10.55089948
104ADRBK10.54696184
105MAP2K40.54180191
106TYK20.53328720
107MAPKAPK50.50009026
108NTRK20.49621218
109MAPK70.48275545
110CSNK1A10.48067949
111VRK20.47044239
112BRSK20.46379802
113TLK10.46185150
114TAOK20.45779549
115PIK3CA0.45253738
116STK30.44387171
117SGK30.43950414
118CAMK2A0.43715075
119PRKCQ0.43413501
120TIE10.43037191
121PRKACG0.42057280
122LIMK10.41330062
123SGK10.41154728
124FER0.40780418
125ARAF0.40334919
126RPS6KA50.38530474
127NEK90.38070681
128DYRK1A0.37963187
129LCK0.37797548
130CCNB10.37612667
131SIK20.37432064
132PRKCI0.37367508
133WNK10.37266996
134PRKCZ0.37081007
135EIF2AK30.35395947
136MAP3K110.34413726
137PRKCA0.34284449
138PRKCD0.33503155
139CSNK2A10.32880398
140CAMK10.32737250
141MYLK0.32519577
142PRKG10.31318312
143ATR0.30802785
144CSNK1E0.30657511
145HCK0.30407470
146TGFBR20.29777469
147GRK50.29684769
148BRAF0.29591354
149MKNK10.29548255
150CAMK2D0.29385427
151CSNK1D0.28947634
152PRKACA0.28081424

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.06390094
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.98197305
3Allograft rejection_Homo sapiens_hsa053302.89373533
4Butanoate metabolism_Homo sapiens_hsa006502.74252451
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.60942680
6Rheumatoid arthritis_Homo sapiens_hsa053232.55389710
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.53834411
8Type I diabetes mellitus_Homo sapiens_hsa049402.24115592
9Autoimmune thyroid disease_Homo sapiens_hsa053202.20233135
10Parkinsons disease_Homo sapiens_hsa050122.19506439
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.19226448
12Caffeine metabolism_Homo sapiens_hsa002322.14977392
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.11768275
14Nicotine addiction_Homo sapiens_hsa050332.10156122
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.06947459
16Intestinal immune network for IgA production_Homo sapiens_hsa046722.02676985
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.01950682
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00259365
19Propanoate metabolism_Homo sapiens_hsa006401.99796790
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.94461446
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.92006819
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.83544467
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.80850309
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.80546853
25Chemical carcinogenesis_Homo sapiens_hsa052041.80380390
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.78301007
27Peroxisome_Homo sapiens_hsa041461.75639183
28Asthma_Homo sapiens_hsa053101.73075047
29Tryptophan metabolism_Homo sapiens_hsa003801.70436834
30Linoleic acid metabolism_Homo sapiens_hsa005911.65351493
31Collecting duct acid secretion_Homo sapiens_hsa049661.63559362
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.62629981
33Retinol metabolism_Homo sapiens_hsa008301.61421207
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.60727984
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.59342459
36Measles_Homo sapiens_hsa051621.57960970
37Fatty acid degradation_Homo sapiens_hsa000711.56555259
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.55690678
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.54138343
40Fanconi anemia pathway_Homo sapiens_hsa034601.53016596
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.47727308
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.46955683
43Basal transcription factors_Homo sapiens_hsa030221.46306651
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44185190
45African trypanosomiasis_Homo sapiens_hsa051431.43523965
46Leishmaniasis_Homo sapiens_hsa051401.38511313
47Nitrogen metabolism_Homo sapiens_hsa009101.38111917
48Hematopoietic cell lineage_Homo sapiens_hsa046401.37160619
49Morphine addiction_Homo sapiens_hsa050321.31355891
50Legionellosis_Homo sapiens_hsa051341.29285477
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.29209661
52Selenocompound metabolism_Homo sapiens_hsa004501.28644500
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.28451708
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27756916
55Malaria_Homo sapiens_hsa051441.27477531
56Sulfur metabolism_Homo sapiens_hsa009201.26160575
57Fatty acid elongation_Homo sapiens_hsa000621.24428495
58Phagosome_Homo sapiens_hsa041451.21046501
59Herpes simplex infection_Homo sapiens_hsa051681.20851714
60Taste transduction_Homo sapiens_hsa047421.20822144
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19855508
62Influenza A_Homo sapiens_hsa051641.16865306
63Cardiac muscle contraction_Homo sapiens_hsa042601.14216257
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13780707
65Tuberculosis_Homo sapiens_hsa051521.12671858
66Fat digestion and absorption_Homo sapiens_hsa049751.12411584
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12225761
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09975708
69Sphingolipid metabolism_Homo sapiens_hsa006001.09812150
70TNF signaling pathway_Homo sapiens_hsa046681.08716111
71Primary immunodeficiency_Homo sapiens_hsa053401.08565883
72Regulation of autophagy_Homo sapiens_hsa041401.06959070
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06543249
74beta-Alanine metabolism_Homo sapiens_hsa004101.06522063
75Serotonergic synapse_Homo sapiens_hsa047261.04647193
76Arachidonic acid metabolism_Homo sapiens_hsa005901.03483477
77Starch and sucrose metabolism_Homo sapiens_hsa005001.02811705
78Fatty acid metabolism_Homo sapiens_hsa012121.02249096
79Jak-STAT signaling pathway_Homo sapiens_hsa046301.00940570
80Glycerolipid metabolism_Homo sapiens_hsa005610.97047805
81RNA degradation_Homo sapiens_hsa030180.97032927
82Osteoclast differentiation_Homo sapiens_hsa043800.95393097
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94668644
84Pertussis_Homo sapiens_hsa051330.94157914
85Phototransduction_Homo sapiens_hsa047440.94115682
86Vitamin digestion and absorption_Homo sapiens_hsa049770.94099998
87Proteasome_Homo sapiens_hsa030500.93377787
88Calcium signaling pathway_Homo sapiens_hsa040200.93256590
89Olfactory transduction_Homo sapiens_hsa047400.93033816
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90723542
91Pyruvate metabolism_Homo sapiens_hsa006200.90646028
92Staphylococcus aureus infection_Homo sapiens_hsa051500.90463858
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.90289595
94Oxidative phosphorylation_Homo sapiens_hsa001900.89758825
95Chemokine signaling pathway_Homo sapiens_hsa040620.88408096
96Homologous recombination_Homo sapiens_hsa034400.88175273
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86921979
98Nucleotide excision repair_Homo sapiens_hsa034200.82213519
99Ether lipid metabolism_Homo sapiens_hsa005650.82156093
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80942238
101Metabolic pathways_Homo sapiens_hsa011000.77676750
102Synaptic vesicle cycle_Homo sapiens_hsa047210.77141680
103Complement and coagulation cascades_Homo sapiens_hsa046100.77132398
104Salmonella infection_Homo sapiens_hsa051320.75532675
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75361300
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75246230
107Steroid biosynthesis_Homo sapiens_hsa001000.74536204
108Glutathione metabolism_Homo sapiens_hsa004800.73456722
109Folate biosynthesis_Homo sapiens_hsa007900.72594268
110Glutamatergic synapse_Homo sapiens_hsa047240.71482746
111PPAR signaling pathway_Homo sapiens_hsa033200.68928531
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66983605
113Circadian entrainment_Homo sapiens_hsa047130.66523654
114RNA polymerase_Homo sapiens_hsa030200.65421200
115Tyrosine metabolism_Homo sapiens_hsa003500.64959097
116GABAergic synapse_Homo sapiens_hsa047270.63789965
117Sulfur relay system_Homo sapiens_hsa041220.63371300
118Vibrio cholerae infection_Homo sapiens_hsa051100.61283488
119Mineral absorption_Homo sapiens_hsa049780.61248653
120Purine metabolism_Homo sapiens_hsa002300.60196728
121Histidine metabolism_Homo sapiens_hsa003400.60129633
122Ovarian steroidogenesis_Homo sapiens_hsa049130.59162883
123Huntingtons disease_Homo sapiens_hsa050160.56918526
124Other glycan degradation_Homo sapiens_hsa005110.56619363
125Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55067977
126Hepatitis B_Homo sapiens_hsa051610.54877861
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.54707412
128cAMP signaling pathway_Homo sapiens_hsa040240.51850924
129Arginine and proline metabolism_Homo sapiens_hsa003300.51440626
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50956172
131ABC transporters_Homo sapiens_hsa020100.49734057
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49676341
133Dopaminergic synapse_Homo sapiens_hsa047280.48866226
134Non-homologous end-joining_Homo sapiens_hsa034500.48146153
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47148411
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46191009
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45626633
138Apoptosis_Homo sapiens_hsa042100.45362039
139Viral myocarditis_Homo sapiens_hsa054160.45039897
140Circadian rhythm_Homo sapiens_hsa047100.44766213
141Renin secretion_Homo sapiens_hsa049240.44104857
142Alzheimers disease_Homo sapiens_hsa050100.43369838
143Fatty acid biosynthesis_Homo sapiens_hsa000610.43007225
144Hepatitis C_Homo sapiens_hsa051600.42082716
145Protein export_Homo sapiens_hsa030600.40630127
146Inositol phosphate metabolism_Homo sapiens_hsa005620.40495825
147Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39498076
148One carbon pool by folate_Homo sapiens_hsa006700.39435497
149Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39185908
150Lysosome_Homo sapiens_hsa041420.38930558
151Salivary secretion_Homo sapiens_hsa049700.37204713
152Insulin secretion_Homo sapiens_hsa049110.37152904
153Vitamin B6 metabolism_Homo sapiens_hsa007500.37077768
154Toxoplasmosis_Homo sapiens_hsa051450.35836256
155Pyrimidine metabolism_Homo sapiens_hsa002400.35194758
156Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35054827
157Glycosaminoglycan degradation_Homo sapiens_hsa005310.34403535
158Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33282340
159Ras signaling pathway_Homo sapiens_hsa040140.33009669
160Melanoma_Homo sapiens_hsa052180.32863057
161Glycerophospholipid metabolism_Homo sapiens_hsa005640.32699874
162Cocaine addiction_Homo sapiens_hsa050300.32313278

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