LYRM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is found in both mitochondria and the nucleus, where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters. Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.67951426
2cullin deneddylation (GO:0010388)4.66020553
3protein complex biogenesis (GO:0070271)4.52912539
4protein deneddylation (GO:0000338)4.50919517
5mitochondrial respiratory chain complex I assembly (GO:0032981)4.38227895
6NADH dehydrogenase complex assembly (GO:0010257)4.38227895
7mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.38227895
82-deoxyribonucleotide biosynthetic process (GO:0009265)4.24995828
9deoxyribose phosphate biosynthetic process (GO:0046385)4.24995828
10proteasome assembly (GO:0043248)4.23948197
11establishment of protein localization to mitochondrial membrane (GO:0090151)4.21787256
12DNA deamination (GO:0045006)4.14565934
13respiratory chain complex IV assembly (GO:0008535)4.12341702
14chaperone-mediated protein transport (GO:0072321)4.02924957
15mitochondrial respiratory chain complex assembly (GO:0033108)3.97202012
16cytochrome complex assembly (GO:0017004)3.92217407
17water-soluble vitamin biosynthetic process (GO:0042364)3.89588270
18transcription elongation from RNA polymerase III promoter (GO:0006385)3.76726464
19termination of RNA polymerase III transcription (GO:0006386)3.76726464
20negative regulation of dendrite morphogenesis (GO:0050774)3.75215985
21positive regulation of mitochondrial fission (GO:0090141)3.74002330
22deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.71142389
23viral transcription (GO:0019083)3.68278971
24oxidative phosphorylation (GO:0006119)3.67256191
25deoxyribonucleotide biosynthetic process (GO:0009263)3.66396234
26translational termination (GO:0006415)3.64861148
27nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.56824962
28regulation of mitochondrial translation (GO:0070129)3.56089649
29metallo-sulfur cluster assembly (GO:0031163)3.54460486
30iron-sulfur cluster assembly (GO:0016226)3.54460486
31platelet dense granule organization (GO:0060155)3.53383993
32polyketide metabolic process (GO:0030638)3.50440088
33doxorubicin metabolic process (GO:0044598)3.50440088
34daunorubicin metabolic process (GO:0044597)3.50440088
35exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.45706055
36intracellular protein transmembrane import (GO:0044743)3.41662402
377-methylguanosine mRNA capping (GO:0006370)3.40662821
38RNA capping (GO:0036260)3.38614484
397-methylguanosine RNA capping (GO:0009452)3.38614484
40protein-cofactor linkage (GO:0018065)3.37670857
41heart process (GO:0003015)3.35640228
42heart contraction (GO:0060047)3.35640228
43L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.35392531
44negative regulation of telomere maintenance (GO:0032205)3.32942305
45CENP-A containing nucleosome assembly (GO:0034080)3.29110081
46pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.29048189
47ribosomal small subunit assembly (GO:0000028)3.26841061
48inositol phosphate catabolic process (GO:0071545)3.26565463
49protein neddylation (GO:0045116)3.25299082
50mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.25197605
51telomere maintenance via semi-conservative replication (GO:0032201)3.24014576
52SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.23232458
53cotranslational protein targeting to membrane (GO:0006613)3.21228974
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.20368582
55nucleotide transmembrane transport (GO:1901679)3.20211564
56negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.16434039
57protein targeting to ER (GO:0045047)3.13876797
58viral mRNA export from host cell nucleus (GO:0046784)3.13293801
59fucose catabolic process (GO:0019317)3.11237081
60L-fucose metabolic process (GO:0042354)3.11237081
61L-fucose catabolic process (GO:0042355)3.11237081
62protein import into peroxisome matrix (GO:0016558)3.10712164
63intraciliary transport (GO:0042073)3.07612007
64regulation of mitotic spindle checkpoint (GO:1903504)3.06671270
65regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.06671270
66signal peptide processing (GO:0006465)3.05942588
67chromatin remodeling at centromere (GO:0031055)3.04759719
68translational elongation (GO:0006414)3.04597075
69telomere maintenance via recombination (GO:0000722)3.04389705
70detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.03363977
71pseudouridine synthesis (GO:0001522)3.00726393
72regulation of nuclear cell cycle DNA replication (GO:0033262)3.00015876
73maturation of SSU-rRNA (GO:0030490)2.99941045
74regulation of cellular amino acid metabolic process (GO:0006521)2.99544431
75replication fork processing (GO:0031297)2.99324368
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.99082624
77establishment of protein localization to endoplasmic reticulum (GO:0072599)2.96892453
78protein localization to endoplasmic reticulum (GO:0070972)2.96399064
79signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.95437540
80signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.95437540
81signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.95437540
82energy coupled proton transport, down electrochemical gradient (GO:0015985)2.93936138
83ATP synthesis coupled proton transport (GO:0015986)2.93936138
84signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.93047349
85intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.93047349
86positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.92713380
87regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92176855
88epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.91746428
89rRNA modification (GO:0000154)2.90742820
90deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.90505466
91kynurenine metabolic process (GO:0070189)2.88870626
92guanosine-containing compound biosynthetic process (GO:1901070)2.87707852
93DNA double-strand break processing (GO:0000729)2.87271073
94maturation of 5.8S rRNA (GO:0000460)2.86057046
95RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85534645
96tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85534645
97cellular protein complex disassembly (GO:0043624)2.85033298
98respiratory electron transport chain (GO:0022904)2.84286712
99tRNA processing (GO:0008033)2.84262028
100deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.83772954
101viral protein processing (GO:0019082)2.83751524
102ATP biosynthetic process (GO:0006754)2.82469253
103anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80972988
104tRNA methylation (GO:0030488)2.80810442
105dopamine transport (GO:0015872)2.80325490
106aerobic respiration (GO:0009060)2.80010466
107epithelial cilium movement (GO:0003351)2.78522943
108signal transduction involved in cell cycle checkpoint (GO:0072395)2.78059982
109negative regulation of ligase activity (GO:0051352)2.77655536
110negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.77655536
111electron transport chain (GO:0022900)2.77012242
112negative regulation of DNA-dependent DNA replication (GO:2000104)2.75500175
113transcription-coupled nucleotide-excision repair (GO:0006283)2.75174167
114signal transduction involved in DNA integrity checkpoint (GO:0072401)2.74703788
115signal transduction involved in DNA damage checkpoint (GO:0072422)2.74703788
116indole-containing compound catabolic process (GO:0042436)2.74276845
117indolalkylamine catabolic process (GO:0046218)2.74276845
118tryptophan catabolic process (GO:0006569)2.74276845
119response to pheromone (GO:0019236)2.73572161
120purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.73563208
121rRNA methylation (GO:0031167)2.73500748
122purine nucleoside triphosphate biosynthetic process (GO:0009145)2.73248920
123cellular response to oxygen radical (GO:0071450)2.70518884
124removal of superoxide radicals (GO:0019430)2.70518884
125cellular response to superoxide (GO:0071451)2.70518884
126protein targeting to mitochondrion (GO:0006626)2.68438435
127DNA ligation (GO:0006266)2.67571179
128sulfation (GO:0051923)2.66944221
129kinetochore assembly (GO:0051382)2.66842503
130spliceosomal snRNP assembly (GO:0000387)2.66809012
131ubiquinone metabolic process (GO:0006743)2.66120230
132cellular component biogenesis (GO:0044085)2.65376619
133translational initiation (GO:0006413)2.64838294
134ribosomal small subunit biogenesis (GO:0042274)2.64037670
135viral life cycle (GO:0019058)2.62954186
136mitotic recombination (GO:0006312)2.62613757
137antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.62494725
138regulation of double-strand break repair via homologous recombination (GO:0010569)2.61663624
139peptidyl-histidine modification (GO:0018202)2.60646060
140recombinational repair (GO:0000725)2.60447297
141transcription elongation from RNA polymerase II promoter (GO:0006368)2.59975312
142translation (GO:0006412)2.59892618
143negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.58993660
144pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.58156532
145negative regulation of dendrite development (GO:2000171)2.58086668
146hydrogen ion transmembrane transport (GO:1902600)2.57914865
147double-strand break repair via homologous recombination (GO:0000724)2.57781005
148DNA catabolic process, exonucleolytic (GO:0000738)2.57692951
149ribosomal large subunit biogenesis (GO:0042273)2.56677783
150mannosylation (GO:0097502)2.56142083
151GMP metabolic process (GO:0046037)2.55697785
152RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.55484307
153indolalkylamine metabolic process (GO:0006586)2.54964354
154intracellular protein transmembrane transport (GO:0065002)2.54783717
155nonmotile primary cilium assembly (GO:0035058)2.53823222
156rRNA catabolic process (GO:0016075)2.50672615
157preassembly of GPI anchor in ER membrane (GO:0016254)2.49439206
158nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.46901123
159DNA replication checkpoint (GO:0000076)2.46593528
160kidney morphogenesis (GO:0060993)2.46031079
161behavioral response to ethanol (GO:0048149)2.45362719
162GTP biosynthetic process (GO:0006183)2.45360732
163proton transport (GO:0015992)2.45354480
164inner mitochondrial membrane organization (GO:0007007)2.44248275
165reciprocal meiotic recombination (GO:0007131)2.44141276
166reciprocal DNA recombination (GO:0035825)2.44141276
167aldehyde catabolic process (GO:0046185)2.41911345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.62639574
2E2F7_22180533_ChIP-Seq_HELA_Human3.73776570
3ZNF274_21170338_ChIP-Seq_K562_Hela3.58642717
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.44942593
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.36437332
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.25653032
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.06155482
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.01953899
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.83749192
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.80729580
11SRF_21415370_ChIP-Seq_HL-1_Mouse2.76302434
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.70286421
13EZH2_22144423_ChIP-Seq_EOC_Human2.62910516
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.59162130
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.53774837
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.44869152
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.31408280
18GBX2_23144817_ChIP-Seq_PC3_Human2.30745581
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.24894168
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20940219
21FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.18684524
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.17240520
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15588726
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.15284609
25* VDR_23849224_ChIP-Seq_CD4+_Human2.09009535
26ELK1_19687146_ChIP-ChIP_HELA_Human2.04501839
27TAF15_26573619_Chip-Seq_HEK293_Human2.04033024
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01499513
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98616642
30YY1_21170310_ChIP-Seq_MESCs_Mouse1.94479383
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92023682
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.91440091
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.88675279
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84888499
35IGF1R_20145208_ChIP-Seq_DFB_Human1.80724699
36* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78834312
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.71829220
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71628210
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69430159
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68166358
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66585380
42IRF1_19129219_ChIP-ChIP_H3396_Human1.65988250
43* FOXP3_21729870_ChIP-Seq_TREG_Human1.63837277
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.59864925
45EWS_26573619_Chip-Seq_HEK293_Human1.59618970
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59414673
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56713276
48* DCP1A_22483619_ChIP-Seq_HELA_Human1.55527719
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54701625
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54235994
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.52195377
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50404498
53GABP_19822575_ChIP-Seq_HepG2_Human1.48312964
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47813374
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47390495
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.46752679
57FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.45762762
58FUS_26573619_Chip-Seq_HEK293_Human1.44613790
59MYC_18940864_ChIP-ChIP_HL60_Human1.43674606
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42738257
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42408689
62TP53_22573176_ChIP-Seq_HFKS_Human1.40514932
63P300_19829295_ChIP-Seq_ESCs_Human1.39335980
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36065706
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34319166
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34041483
67TTF2_22483619_ChIP-Seq_HELA_Human1.33014752
68VDR_22108803_ChIP-Seq_LS180_Human1.32026564
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.28062506
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.27344575
71NANOG_19829295_ChIP-Seq_ESCs_Human1.24583132
72SOX2_19829295_ChIP-Seq_ESCs_Human1.24583132
73RNF2_27304074_Chip-Seq_NSC_Mouse1.24329586
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23674742
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.23674742
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.22504578
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20240962
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19706977
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.18947535
80SOX2_16153702_ChIP-ChIP_HESCs_Human1.17694116
81ER_23166858_ChIP-Seq_MCF-7_Human1.16974800
82* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16474234
83BCAT_22108803_ChIP-Seq_LS180_Human1.15067992
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14830364
85CBP_20019798_ChIP-Seq_JUKART_Human1.14152794
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14152794
87GATA3_21878914_ChIP-Seq_MCF-7_Human1.13541626
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13507310
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11467752
90REST_21632747_ChIP-Seq_MESCs_Mouse1.10393031
91CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09567572
92NCOR_22424771_ChIP-Seq_293T_Human1.09541615
93ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08150330
94AR_20517297_ChIP-Seq_VCAP_Human1.08112461
95CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07829553
96POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07814517
97PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07192230
98CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06278827
99AR_25329375_ChIP-Seq_VCAP_Human1.05278675
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05190532
101STAT3_18555785_Chip-Seq_ESCs_Mouse1.02808577
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01813054
103POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01670639
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01392976
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01392976
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01218792
107TCF4_22108803_ChIP-Seq_LS180_Human0.99888382
108XRN2_22483619_ChIP-Seq_HELA_Human0.99647169
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99455514
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98669941
111IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98562096
112JUN_21703547_ChIP-Seq_K562_Human0.97825657
113SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97075028
114P53_22387025_ChIP-Seq_ESCs_Mouse0.95484204
115NFE2_27457419_Chip-Seq_LIVER_Mouse0.94748501
116MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94326289
117SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94132000
118E2F1_18555785_Chip-Seq_ESCs_Mouse0.93998206
119* STAT3_23295773_ChIP-Seq_U87_Human0.93645988
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93608628
121KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93572518
122* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93550818
123* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93161775
124MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92960857
125NANOG_18555785_Chip-Seq_ESCs_Mouse0.92749920
126CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92663617
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92543704
128NANOG_16153702_ChIP-ChIP_HESCs_Human0.92311233
129NMYC_18555785_Chip-Seq_ESCs_Mouse0.91887554
130SMAD3_21741376_ChIP-Seq_EPCs_Human0.90601123
131EZH2_27294783_Chip-Seq_NPCs_Mouse0.90345077
132NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90318637
133EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90230689
134BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90185365
135TCF4_23295773_ChIP-Seq_U87_Human0.89470945
136E2F1_21310950_ChIP-Seq_MCF-7_Human0.88289796
137* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88162126
138NANOG_20526341_ChIP-Seq_ESCs_Human0.87583413
139MYC_19079543_ChIP-ChIP_MESCs_Mouse0.87045871
140TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86643296
141MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86574438
142RUNX1_27457419_Chip-Seq_LIVER_Mouse0.84936710
143SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82931423
144P300_18555785_Chip-Seq_ESCs_Mouse0.82629941

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity4.04234423
2MP0001188_hyperpigmentation2.71933829
3MP0004147_increased_porphyrin_level2.68391282
4MP0003880_abnormal_central_pattern2.65279506
5MP0008877_abnormal_DNA_methylation2.63353128
6MP0005646_abnormal_pituitary_gland2.52818340
7MP0002735_abnormal_chemical_nociception2.46872869
8MP0006292_abnormal_olfactory_placode2.42953199
9MP0003787_abnormal_imprinting2.37905394
10MP0000372_irregular_coat_pigmentation2.35536981
11MP0008789_abnormal_olfactory_epithelium2.35388344
12MP0006276_abnormal_autonomic_nervous2.30365952
13MP0000015_abnormal_ear_pigmentation2.29350405
14MP0008058_abnormal_DNA_repair2.27157927
15MP0002254_reproductive_system_inflammat2.20762773
16MP0002736_abnormal_nociception_after2.16632146
17MP0002876_abnormal_thyroid_physiology2.16473338
18MP0006072_abnormal_retinal_apoptosis2.15965536
19MP0005551_abnormal_eye_electrophysiolog2.14897347
20MP0009697_abnormal_copulation2.14746605
21MP0005394_taste/olfaction_phenotype2.14345850
22MP0005499_abnormal_olfactory_system2.14345850
23MP0002837_dystrophic_cardiac_calcinosis2.07157256
24MP0003195_calcinosis2.05500602
25MP0000566_synostosis2.05041803
26MP0002132_abnormal_respiratory_system2.04800250
27MP0003186_abnormal_redox_activity1.99090388
28MP0001984_abnormal_olfaction1.98861912
29MP0002638_abnormal_pupillary_reflex1.91704642
30MP0001968_abnormal_touch/_nociception1.85525441
31MP0008007_abnormal_cellular_replicative1.81355615
32MP0010094_abnormal_chromosome_stability1.80764152
33MP0003693_abnormal_embryo_hatching1.80604291
34MP0001529_abnormal_vocalization1.78275189
35MP0003011_delayed_dark_adaptation1.74759660
36MP0002751_abnormal_autonomic_nervous1.70598351
37MP0002653_abnormal_ependyma_morphology1.61599302
38MP0001293_anophthalmia1.59502175
39MP0008875_abnormal_xenobiotic_pharmacok1.58891608
40MP0001905_abnormal_dopamine_level1.58765094
41MP0002160_abnormal_reproductive_system1.57264271
42MP0005253_abnormal_eye_physiology1.57077798
43MP0005171_absent_coat_pigmentation1.57005611
44MP0003786_premature_aging1.56777808
45MP0004885_abnormal_endolymph1.55183900
46MP0003718_maternal_effect1.53451905
47MP0003122_maternal_imprinting1.49852413
48MP0008872_abnormal_physiological_respon1.45224015
49MP0005645_abnormal_hypothalamus_physiol1.45143206
50MP0004133_heterotaxia1.43573156
51MP0002734_abnormal_mechanical_nocicepti1.41597776
52MP0005075_abnormal_melanosome_morpholog1.40742773
53MP0004270_analgesia1.39456164
54MP0003121_genomic_imprinting1.36995889
55MP0002234_abnormal_pharynx_morphology1.36712432
56MP0003878_abnormal_ear_physiology1.33587145
57MP0005377_hearing/vestibular/ear_phenot1.33587145
58MP0004742_abnormal_vestibular_system1.23548186
59MP0003656_abnormal_erythrocyte_physiolo1.23524661
60MP0001919_abnormal_reproductive_system1.21095892
61MP0002095_abnormal_skin_pigmentation1.20983075
62MP0005195_abnormal_posterior_eye1.17771157
63MP0005389_reproductive_system_phenotype1.17099481
64MP0006036_abnormal_mitochondrial_physio1.15864866
65MP0005408_hypopigmentation1.15577167
66MP0009745_abnormal_behavioral_response1.15236680
67MP0002272_abnormal_nervous_system1.13169258
68MP0003937_abnormal_limbs/digits/tail_de1.09667119
69MP0001486_abnormal_startle_reflex1.07970201
70MP0001764_abnormal_homeostasis1.07878722
71MP0002277_abnormal_respiratory_mucosa1.06589297
72MP0003567_abnormal_fetal_cardiomyocyte1.04045406
73MP0004957_abnormal_blastocyst_morpholog1.03385099
74MP0009379_abnormal_foot_pigmentation1.02760540
75MP0004142_abnormal_muscle_tone1.02621327
76MP0009046_muscle_twitch1.02085687
77MP0001119_abnormal_female_reproductive1.01770416
78MP0002752_abnormal_somatic_nervous1.01315943
79MP0002163_abnormal_gland_morphology1.00951426
80MP0005423_abnormal_somatic_nervous1.00465322
81MP0008260_abnormal_autophagy1.00424062
82MP0010386_abnormal_urinary_bladder0.99929527
83MP0002067_abnormal_sensory_capabilities0.98734066
84MP0000049_abnormal_middle_ear0.98587688
85MP0003077_abnormal_cell_cycle0.96523729
86MP0003136_yellow_coat_color0.94826732
87MP0002938_white_spotting0.94383630
88MP0004782_abnormal_surfactant_physiolog0.94189437
89MP0000026_abnormal_inner_ear0.93664946
90MP0002572_abnormal_emotion/affect_behav0.93040962
91MP0001970_abnormal_pain_threshold0.92958808
92MP0001963_abnormal_hearing_physiology0.92414121
93MP0000490_abnormal_crypts_of0.92315665
94MP0008057_abnormal_DNA_replication0.92171825
95MP0000778_abnormal_nervous_system0.92122034
96MP0003119_abnormal_digestive_system0.91896712
97MP0003315_abnormal_perineum_morphology0.90581910
98MP0003806_abnormal_nucleotide_metabolis0.89775859
99MP0004145_abnormal_muscle_electrophysio0.89481005
100MP0008932_abnormal_embryonic_tissue0.89156618
101MP0002102_abnormal_ear_morphology0.88724244
102MP0002557_abnormal_social/conspecific_i0.88713538
103MP0000631_abnormal_neuroendocrine_gland0.86994355
104MP0004043_abnormal_pH_regulation0.86780820
105MP0000681_abnormal_thyroid_gland0.85924469
106MP0006082_CNS_inflammation0.85881733
107MP0001346_abnormal_lacrimal_gland0.85024149
108MP0005174_abnormal_tail_pigmentation0.84797985
109MP0002063_abnormal_learning/memory/cond0.84620721
110MP0002009_preneoplasia0.84585688
111MP0010030_abnormal_orbit_morphology0.84435018
112MP0003698_abnormal_male_reproductive0.84287362
113MP0002148_abnormal_hypersensitivity_rea0.82907458
114MP0000427_abnormal_hair_cycle0.82760775
115MP0005391_vision/eye_phenotype0.82506814
116MP0002733_abnormal_thermal_nociception0.82273805
117MP0001485_abnormal_pinna_reflex0.82264852
118MP0001929_abnormal_gametogenesis0.81901856
119MP0003890_abnormal_embryonic-extraembry0.81541195
120MP0001542_abnormal_bone_strength0.81191391
121MP0006035_abnormal_mitochondrial_morpho0.80615198
122MP0001186_pigmentation_phenotype0.79602170
123MP0006054_spinal_hemorrhage0.78477701
124MP0000678_abnormal_parathyroid_gland0.77798492
125MP0003646_muscle_fatigue0.77472742
126MP0002184_abnormal_innervation0.77290803
127MP0002210_abnormal_sex_determination0.76823836
128MP0003111_abnormal_nucleus_morphology0.76333892
129MP0005379_endocrine/exocrine_gland_phen0.75862011
130MP0000749_muscle_degeneration0.75105796
131MP0003123_paternal_imprinting0.72295910
132MP0003635_abnormal_synaptic_transmissio0.69786071
133MP0005084_abnormal_gallbladder_morpholo0.67662823
134MP0002064_seizures0.67237796
135MP0003724_increased_susceptibility_to0.67236504
136MP0001501_abnormal_sleep_pattern0.66064879
137MP0003879_abnormal_hair_cell0.64970185
138MP0008995_early_reproductive_senescence0.64064016

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.66046863
2Hypothermia (HP:0002045)4.35617991
3Abnormal mitochondria in muscle tissue (HP:0008316)4.31731597
4Mitochondrial inheritance (HP:0001427)4.18118019
5Progressive macrocephaly (HP:0004481)3.92975923
6Increased CSF lactate (HP:0002490)3.89677933
7Abnormal hair whorl (HP:0010721)3.88126294
8Hepatocellular necrosis (HP:0001404)3.74185441
9Abnormality of midbrain morphology (HP:0002418)3.64182069
10Molar tooth sign on MRI (HP:0002419)3.64182069
11Acute encephalopathy (HP:0006846)3.58856937
12True hermaphroditism (HP:0010459)3.56319986
13Abnormality of the heme biosynthetic pathway (HP:0010472)3.51400498
14Medial flaring of the eyebrow (HP:0010747)3.49885585
15Hepatic necrosis (HP:0002605)3.24165586
16Congenital primary aphakia (HP:0007707)3.20851302
17Nephrogenic diabetes insipidus (HP:0009806)3.19862308
18Pancreatic fibrosis (HP:0100732)3.17175444
19Gait imbalance (HP:0002141)3.13910911
20Congenital stationary night blindness (HP:0007642)3.12426842
21Nephronophthisis (HP:0000090)3.12411546
22Type I transferrin isoform profile (HP:0003642)3.10881057
23Type II lissencephaly (HP:0007260)2.99786425
24Increased serum lactate (HP:0002151)2.96769230
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.93871407
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.86171781
27Febrile seizures (HP:0002373)2.83828400
28Increased hepatocellular lipid droplets (HP:0006565)2.83179449
29Exercise intolerance (HP:0003546)2.80755115
303-Methylglutaconic aciduria (HP:0003535)2.74316531
31Abnormality of cells of the erythroid lineage (HP:0012130)2.69736878
32Abnormality of the renal medulla (HP:0100957)2.68166311
33Birth length less than 3rd percentile (HP:0003561)2.66501859
34Reticulocytopenia (HP:0001896)2.65804657
35Poor coordination (HP:0002370)2.65158601
36Pendular nystagmus (HP:0012043)2.63860584
37Sclerocornea (HP:0000647)2.63221620
38Type 2 muscle fiber atrophy (HP:0003554)2.60979845
39Aplastic anemia (HP:0001915)2.56793769
40Colon cancer (HP:0003003)2.53304615
41* Lactic acidosis (HP:0003128)2.53036415
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.50553888
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.50553888
44Optic disc pallor (HP:0000543)2.49211512
45Renal Fanconi syndrome (HP:0001994)2.48335156
46Pancreatic cysts (HP:0001737)2.48221531
47Abolished electroretinogram (ERG) (HP:0000550)2.46943147
48Respiratory difficulties (HP:0002880)2.46571373
49Lipid accumulation in hepatocytes (HP:0006561)2.44398482
50Methylmalonic acidemia (HP:0002912)2.41548816
51Chromosomal breakage induced by crosslinking agents (HP:0003221)2.40757763
52Chromsome breakage (HP:0040012)2.38784233
53Aplasia/Hypoplasia of the spleen (HP:0010451)2.38413537
54Cystic liver disease (HP:0006706)2.37883015
55Attenuation of retinal blood vessels (HP:0007843)2.35437191
56Cerebellar dysplasia (HP:0007033)2.35072433
57Abnormality of the renal cortex (HP:0011035)2.34620295
58Exertional dyspnea (HP:0002875)2.33832151
59Polydipsia (HP:0001959)2.33555299
60Abnormal drinking behavior (HP:0030082)2.33555299
61Septo-optic dysplasia (HP:0100842)2.31946918
62Focal motor seizures (HP:0011153)2.30366757
63Genital tract atresia (HP:0001827)2.29818769
64Asplenia (HP:0001746)2.28944182
65Abnormality of the labia minora (HP:0012880)2.27914566
66Abnormal biliary tract physiology (HP:0012439)2.27629514
67Bile duct proliferation (HP:0001408)2.27629514
68Hyperalaninemia (HP:0003348)2.25563988
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25563988
70Abnormality of alanine metabolism (HP:0010916)2.25563988
71Congenital, generalized hypertrichosis (HP:0004540)2.25215057
72Abnormality of glycolysis (HP:0004366)2.24390632
73Increased serum pyruvate (HP:0003542)2.24390632
74Vaginal atresia (HP:0000148)2.24273556
75Respiratory failure (HP:0002878)2.23444335
76Methylmalonic aciduria (HP:0012120)2.23435299
77Abnormality of the pons (HP:0007361)2.23118854
78Abnormality of the anterior horn cell (HP:0006802)2.22496058
79Degeneration of anterior horn cells (HP:0002398)2.22496058
8011 pairs of ribs (HP:0000878)2.21000152
81Hypoplasia of the pons (HP:0012110)2.20136874
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.18787916
83Renal tubular dysfunction (HP:0000124)2.17494442
84Abnormal protein glycosylation (HP:0012346)2.13612439
85Abnormal glycosylation (HP:0012345)2.13612439
86Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13612439
87Abnormal protein N-linked glycosylation (HP:0012347)2.13612439
88Absent thumb (HP:0009777)2.12982518
89Optic nerve hypoplasia (HP:0000609)2.12705387
90Hyperglycinemia (HP:0002154)2.11365443
91Thyroid carcinoma (HP:0002890)2.10558517
92Tubular atrophy (HP:0000092)2.09757977
93Anencephaly (HP:0002323)2.07635965
94Abnormal number of erythroid precursors (HP:0012131)2.05863631
95Aplasia/Hypoplasia of the uvula (HP:0010293)2.04508536
96Hyperventilation (HP:0002883)2.04150453
97Muscle fiber atrophy (HP:0100295)2.03861387
98Chronic hepatic failure (HP:0100626)2.02652188
99Hypoplasia of the fovea (HP:0007750)2.01486526
100Aplasia/Hypoplasia of the fovea (HP:0008060)2.01486526
101Aplasia/Hypoplasia of the tongue (HP:0010295)2.01145460
102Macrocytic anemia (HP:0001972)2.00515874
103Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99865779
104Large for gestational age (HP:0001520)1.98517767
105Neuroendocrine neoplasm (HP:0100634)1.98110014
106Furrowed tongue (HP:0000221)1.98034625
107Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95401758
108Increased intramyocellular lipid droplets (HP:0012240)1.92569233
109Supernumerary spleens (HP:0009799)1.92522964
110Polyuria (HP:0000103)1.92290415
111Lissencephaly (HP:0001339)1.91769798
112Anophthalmia (HP:0000528)1.90667158
113Brushfield spots (HP:0001088)1.89771906
114Broad foot (HP:0001769)1.89105901
115Decreased central vision (HP:0007663)1.88109534
116Chorioretinal atrophy (HP:0000533)1.86315781
117Abnormality of the preputium (HP:0100587)1.86203612
118Preaxial hand polydactyly (HP:0001177)1.84829179
119Microvesicular hepatic steatosis (HP:0001414)1.84412062
120Tongue fasciculations (HP:0001308)1.84140399
121Reduced antithrombin III activity (HP:0001976)1.82253076
122Hyperglycinuria (HP:0003108)1.82013996
123Abnormality of serum amino acid levels (HP:0003112)1.81636097
124Aplasia/Hypoplasia of the lens (HP:0008063)1.81424606
125Congenital hepatic fibrosis (HP:0002612)1.81206987
126Cerebral edema (HP:0002181)1.80765546
127Rib fusion (HP:0000902)1.80449198
128Abnormality of renal resorption (HP:0011038)1.80309788
129Aplasia/Hypoplasia of the patella (HP:0006498)1.80110987
130Epileptic encephalopathy (HP:0200134)1.80046019
131Concave nail (HP:0001598)1.79751960
132Dandy-Walker malformation (HP:0001305)1.79671468
133Triphalangeal thumb (HP:0001199)1.77221040
134Lethargy (HP:0001254)1.77119925
135Aganglionic megacolon (HP:0002251)1.76153578
136Bilateral microphthalmos (HP:0007633)1.75819293
137Poor suck (HP:0002033)1.75410012
138Bony spicule pigmentary retinopathy (HP:0007737)1.74102902
139Osteomalacia (HP:0002749)1.73233362
140Atonic seizures (HP:0010819)1.72962328
141Pheochromocytoma (HP:0002666)1.72327451
142Intestinal atresia (HP:0011100)1.72280873
143Irregular epiphyses (HP:0010582)1.72020784
144Aplasia/Hypoplasia of the tibia (HP:0005772)1.71158988
145Keratoconus (HP:0000563)1.68836288
146Increased corneal curvature (HP:0100692)1.68836288
147Abnormal rod and cone electroretinograms (HP:0008323)1.67973938
148Severe visual impairment (HP:0001141)1.67729688
149Abnormality of the fovea (HP:0000493)1.66462367
150Abnormal lung lobation (HP:0002101)1.65936989
151Leukodystrophy (HP:0002415)1.64829086
152Postaxial foot polydactyly (HP:0001830)1.63979240
153Protruding tongue (HP:0010808)1.63372071
154Meckel diverticulum (HP:0002245)1.62317010
155Unsteady gait (HP:0002317)1.61983207
156Median cleft lip (HP:0000161)1.61326910
157Breast hypoplasia (HP:0003187)1.60135505
158Abnormality of the ileum (HP:0001549)1.59449335
159Abnormality of the columella (HP:0009929)1.58206123
160Male pseudohermaphroditism (HP:0000037)1.58133045
161Patellar aplasia (HP:0006443)1.57968844
162Clubbing of toes (HP:0100760)1.57683262
163Short tibia (HP:0005736)1.57564596

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.78536721
2FRK3.93003629
3SIK32.82726656
4VRK22.72575976
5MKNK22.67643382
6MKNK12.63982503
7STK162.61304887
8WNK32.54921275
9MAP2K72.35514055
10MAP3K122.33156043
11AKT32.32790225
12NUAK12.31546057
13WNK42.15765012
14SGK22.15097846
15ERBB32.14385512
16PASK2.12841799
17MUSK2.09060628
18PRPF4B2.09058933
19BMPR22.03875032
20STK242.02530784
21EIF2AK11.95599205
22CCNB11.95140884
23ZAK1.90149645
24STK38L1.88600096
25MAP4K21.80168351
26PLK41.79235059
27VRK11.78512671
28BCKDK1.73429855
29CDK81.73045475
30INSRR1.72358240
31BMPR1B1.69491316
32SRPK11.67844666
33TSSK61.60684388
34PLK21.58318920
35BUB11.53770610
36YES11.50722081
37TRIM281.46841881
38BRAF1.42918258
39NME11.42128587
40SGK4941.34543105
41SGK2231.34543105
42MAPK131.33902325
43TGFBR11.33741352
44ACVR1B1.31067386
45BRSK21.24461327
46ADRBK21.24235367
47OXSR11.22305575
48STK391.20365668
49EIF2AK31.19164778
50PLK31.15665969
51MAP3K141.14459900
52MYLK1.11820934
53PNCK1.08599389
54SGK31.05339684
55TAF11.02809467
56TNIK0.99592271
57IRAK40.98981468
58CSNK1G20.95793964
59IRAK30.95788317
60PIM20.94612174
61CSNK1G10.94553196
62CDK190.94250738
63BRSK10.91135389
64PINK10.88363047
65EIF2AK20.88173357
66CSNK1G30.87580210
67DAPK10.86962929
68NTRK30.86834026
69TAOK30.86309143
70TXK0.86061606
71TIE10.85950195
72ARAF0.84376514
73WEE10.82348217
74GRK70.81106972
75CDC70.81071734
76MST40.77968755
77PBK0.76828133
78MINK10.76721795
79BCR0.75824056
80PAK30.75453712
81EPHA40.74253981
82TEC0.73082751
83OBSCN0.71432205
84CDK30.71251631
85NME20.70063019
86NEK90.70000703
87DYRK30.69039287
88NEK60.68287209
89CSNK1A1L0.66763910
90NEK10.64749320
91NTRK20.64657400
92PLK10.62608470
93AURKA0.62237948
94TTK0.60964945
95DYRK20.60402623
96PKN10.59714522
97RPS6KA50.59336197
98RPS6KB10.58581591
99FGFR20.58063973
100NEK20.56356284
101PHKG10.55800303
102PHKG20.55800303
103DAPK20.54077619
104PRKCG0.53993548
105PRKCQ0.53219634
106MAPK150.52063408
107PRKCE0.48599988
108MARK10.47831420
109ITK0.47310916
110TNK20.46963317
111CSNK1A10.46660052
112RPS6KC10.46221491
113RPS6KL10.46221491
114PIM10.45542347
115RPS6KA60.45052363
116EPHB20.44883376
117CSNK2A10.43324844
118MATK0.42478347
119IKBKE0.41962997
120MAP3K40.40992373
121ERBB40.39335118
122CAMK10.38894203
123ATR0.38546552
124FLT30.38004276
125PIK3CA0.37932711
126CAMK2A0.37581531
127STK110.37289189
128ATM0.37132442
129CSNK2A20.36036087
130FGFR10.35523747
131CHEK20.34651569
132PDK20.34613145
133CSNK1E0.34508944
134MAPKAPK50.34324173
135RPS6KA20.32717369
136DYRK1A0.30488320
137KSR10.28837775
138TLK10.26750637
139TRPM70.26593958
140AURKB0.26552311
141PRKCI0.26390283
142PRKACA0.25591119
143CAMKK20.24429291
144ADRBK10.24247448
145IKBKB0.24036386
146GRK50.23986504
147PRKCD0.23852908
148GRK10.23206451
149RAF10.22403610

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.87645210
2Oxidative phosphorylation_Homo sapiens_hsa001903.59334499
3RNA polymerase_Homo sapiens_hsa030203.26935023
4DNA replication_Homo sapiens_hsa030303.09197295
5Parkinsons disease_Homo sapiens_hsa050123.05413898
6Mismatch repair_Homo sapiens_hsa034302.85577098
7Protein export_Homo sapiens_hsa030602.63127073
8Homologous recombination_Homo sapiens_hsa034402.50091382
9Huntingtons disease_Homo sapiens_hsa050162.49629462
10Basal transcription factors_Homo sapiens_hsa030222.36990981
11Pyrimidine metabolism_Homo sapiens_hsa002402.27067386
12Base excision repair_Homo sapiens_hsa034102.19389238
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.16759469
14Nucleotide excision repair_Homo sapiens_hsa034202.11231744
15Alzheimers disease_Homo sapiens_hsa050102.10546418
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.98794143
17Collecting duct acid secretion_Homo sapiens_hsa049661.92724652
18Non-homologous end-joining_Homo sapiens_hsa034501.91697826
19RNA degradation_Homo sapiens_hsa030181.84521128
20Fanconi anemia pathway_Homo sapiens_hsa034601.79947864
21Ribosome_Homo sapiens_hsa030101.71249745
22Nitrogen metabolism_Homo sapiens_hsa009101.67029912
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66843783
24Purine metabolism_Homo sapiens_hsa002301.64285856
25Linoleic acid metabolism_Homo sapiens_hsa005911.59688642
26Selenocompound metabolism_Homo sapiens_hsa004501.54882810
27Butanoate metabolism_Homo sapiens_hsa006501.54641051
28Spliceosome_Homo sapiens_hsa030401.52936953
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.51268156
30Cell cycle_Homo sapiens_hsa041101.48932438
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.47903813
32Synaptic vesicle cycle_Homo sapiens_hsa047211.44307596
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41022139
34Propanoate metabolism_Homo sapiens_hsa006401.38162623
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.36468436
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34081405
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31677888
38Sulfur relay system_Homo sapiens_hsa041221.30632053
39Caffeine metabolism_Homo sapiens_hsa002321.28731351
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25767604
41Vibrio cholerae infection_Homo sapiens_hsa051101.25412564
42RNA transport_Homo sapiens_hsa030131.25096920
43Tryptophan metabolism_Homo sapiens_hsa003801.24402044
44Rheumatoid arthritis_Homo sapiens_hsa053231.10609626
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.09031627
46Nicotine addiction_Homo sapiens_hsa050331.07857368
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01775540
48Arachidonic acid metabolism_Homo sapiens_hsa005901.01028058
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01001943
50Cardiac muscle contraction_Homo sapiens_hsa042600.97672486
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97548999
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97440034
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.96376918
54Taste transduction_Homo sapiens_hsa047420.91707644
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89861503
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88055223
57Serotonergic synapse_Homo sapiens_hsa047260.85333357
58Steroid biosynthesis_Homo sapiens_hsa001000.85296998
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83862721
60Phototransduction_Homo sapiens_hsa047440.82574074
61One carbon pool by folate_Homo sapiens_hsa006700.81662129
62Chemical carcinogenesis_Homo sapiens_hsa052040.81187654
63N-Glycan biosynthesis_Homo sapiens_hsa005100.80443904
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77935076
65Type I diabetes mellitus_Homo sapiens_hsa049400.77407585
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.76831200
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76778419
68Retinol metabolism_Homo sapiens_hsa008300.75651359
69Olfactory transduction_Homo sapiens_hsa047400.75009628
70Regulation of autophagy_Homo sapiens_hsa041400.72776926
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72651769
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70961932
73Epstein-Barr virus infection_Homo sapiens_hsa051690.69675373
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.68064266
75Metabolic pathways_Homo sapiens_hsa011000.67860655
76Galactose metabolism_Homo sapiens_hsa000520.66782093
77Phagosome_Homo sapiens_hsa041450.66656246
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65180011
79Fructose and mannose metabolism_Homo sapiens_hsa000510.64051439
80Legionellosis_Homo sapiens_hsa051340.62808449
81beta-Alanine metabolism_Homo sapiens_hsa004100.61574130
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60783833
83Vitamin digestion and absorption_Homo sapiens_hsa049770.60438904
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.59393883
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56797701
86Basal cell carcinoma_Homo sapiens_hsa052170.54052690
87mRNA surveillance pathway_Homo sapiens_hsa030150.52735637
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51903878
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50906120
90Mineral absorption_Homo sapiens_hsa049780.50154148
91Oocyte meiosis_Homo sapiens_hsa041140.49904443
92Fat digestion and absorption_Homo sapiens_hsa049750.49716774
93Fatty acid elongation_Homo sapiens_hsa000620.49180406
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49044106
95Thyroid cancer_Homo sapiens_hsa052160.48199187
96Glutathione metabolism_Homo sapiens_hsa004800.47560931
97Sulfur metabolism_Homo sapiens_hsa009200.46715956
98Autoimmune thyroid disease_Homo sapiens_hsa053200.46304363
99Allograft rejection_Homo sapiens_hsa053300.44785236
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43817394
101Circadian rhythm_Homo sapiens_hsa047100.43471437
102Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42760264
103Glycerolipid metabolism_Homo sapiens_hsa005610.42195425
104p53 signaling pathway_Homo sapiens_hsa041150.41963065
105Hedgehog signaling pathway_Homo sapiens_hsa043400.41644125
106GABAergic synapse_Homo sapiens_hsa047270.39822452
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39329887
108Amphetamine addiction_Homo sapiens_hsa050310.37201320
109Pyruvate metabolism_Homo sapiens_hsa006200.36536032
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36429419
111Herpes simplex infection_Homo sapiens_hsa051680.36270946
112Folate biosynthesis_Homo sapiens_hsa007900.35001845
113Primary immunodeficiency_Homo sapiens_hsa053400.33866117
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33161419
115Circadian entrainment_Homo sapiens_hsa047130.31870397
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31736484
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30848467
118Fatty acid degradation_Homo sapiens_hsa000710.30762261
119Glutamatergic synapse_Homo sapiens_hsa047240.30727472
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30616550
121Graft-versus-host disease_Homo sapiens_hsa053320.30168003
122Morphine addiction_Homo sapiens_hsa050320.30117250
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28086305
124Dopaminergic synapse_Homo sapiens_hsa047280.27504956
125Tyrosine metabolism_Homo sapiens_hsa003500.26967858
126Intestinal immune network for IgA production_Homo sapiens_hsa046720.26858053
127Peroxisome_Homo sapiens_hsa041460.26438785
128Drug metabolism - other enzymes_Homo sapiens_hsa009830.25436034
129Hematopoietic cell lineage_Homo sapiens_hsa046400.25075311
130Insulin secretion_Homo sapiens_hsa049110.24394580
131Asthma_Homo sapiens_hsa053100.22494522
132Ether lipid metabolism_Homo sapiens_hsa005650.22486934
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21350285
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21275101
135Alcoholism_Homo sapiens_hsa050340.21036359
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.20313658
137Long-term potentiation_Homo sapiens_hsa047200.18219045
138Calcium signaling pathway_Homo sapiens_hsa040200.15968932

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