LYRM5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.98816001
2L-phenylalanine catabolic process (GO:0006559)5.98816001
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.70149079
4L-phenylalanine metabolic process (GO:0006558)5.70149079
5aromatic amino acid family catabolic process (GO:0009074)5.05692906
6protein neddylation (GO:0045116)4.95447764
7short-chain fatty acid metabolic process (GO:0046459)4.66554059
8fatty acid beta-oxidation (GO:0006635)4.65932917
9branched-chain amino acid catabolic process (GO:0009083)4.63584009
10glyoxylate metabolic process (GO:0046487)4.60152260
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.51987192
12regulation of sequestering of triglyceride (GO:0010889)4.50551414
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.47834471
14fatty acid oxidation (GO:0019395)4.35269325
15lipid oxidation (GO:0034440)4.28536230
16fatty acid catabolic process (GO:0009062)4.28276552
17tryptophan catabolic process (GO:0006569)4.27204851
18indole-containing compound catabolic process (GO:0042436)4.27204851
19indolalkylamine catabolic process (GO:0046218)4.27204851
20lysine metabolic process (GO:0006553)4.22842332
21lysine catabolic process (GO:0006554)4.22842332
22bile acid biosynthetic process (GO:0006699)4.22458919
23regulation of triglyceride catabolic process (GO:0010896)4.17009409
24platelet dense granule organization (GO:0060155)4.13156172
25branched-chain amino acid metabolic process (GO:0009081)4.12342353
26tryptophan metabolic process (GO:0006568)4.10370677
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.09301518
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.07036858
29cellular ketone body metabolic process (GO:0046950)4.05731749
30alpha-linolenic acid metabolic process (GO:0036109)3.99506470
31monocarboxylic acid catabolic process (GO:0072329)3.97351029
32valine metabolic process (GO:0006573)3.96825655
33coenzyme catabolic process (GO:0009109)3.96208646
34kynurenine metabolic process (GO:0070189)3.94226821
35sulfur amino acid catabolic process (GO:0000098)3.89197548
36amino-acid betaine metabolic process (GO:0006577)3.88489656
37cysteine metabolic process (GO:0006534)3.86699130
38ATP synthesis coupled proton transport (GO:0015986)3.85190218
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.85190218
40protein complex biogenesis (GO:0070271)3.84848208
41water-soluble vitamin biosynthetic process (GO:0042364)3.83984874
42regulation of hexokinase activity (GO:1903299)3.83798667
43regulation of glucokinase activity (GO:0033131)3.83798667
44acetyl-CoA metabolic process (GO:0006084)3.81477654
45respiratory chain complex IV assembly (GO:0008535)3.81049459
46aromatic amino acid family metabolic process (GO:0009072)3.77034787
47peptidyl-glutamic acid carboxylation (GO:0017187)3.75556740
48protein carboxylation (GO:0018214)3.75556740
49homocysteine metabolic process (GO:0050667)3.75081420
50alpha-amino acid catabolic process (GO:1901606)3.72255337
51response to pheromone (GO:0019236)3.69835534
52serine family amino acid catabolic process (GO:0009071)3.65694879
53organic acid catabolic process (GO:0016054)3.64607740
54carboxylic acid catabolic process (GO:0046395)3.64607740
55respiratory electron transport chain (GO:0022904)3.63477027
56cellular amino acid catabolic process (GO:0009063)3.60559261
57ethanol oxidation (GO:0006069)3.58515903
58acylglycerol homeostasis (GO:0055090)3.57846740
59triglyceride homeostasis (GO:0070328)3.57846740
60tyrosine metabolic process (GO:0006570)3.57671217
61high-density lipoprotein particle remodeling (GO:0034375)3.56388481
62aspartate family amino acid catabolic process (GO:0009068)3.53950484
63electron transport chain (GO:0022900)3.53593167
64ketone body metabolic process (GO:1902224)3.53165092
65bile acid metabolic process (GO:0008206)3.52224112
66mitochondrial respiratory chain complex I assembly (GO:0032981)3.50975924
67NADH dehydrogenase complex assembly (GO:0010257)3.50975924
68mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.50975924
69DNA double-strand break processing (GO:0000729)3.50872325
70fatty acid transmembrane transport (GO:1902001)3.48823291
71aldehyde catabolic process (GO:0046185)3.47807713
72succinate metabolic process (GO:0006105)3.47609192
73mitochondrial respiratory chain complex assembly (GO:0033108)3.45416607
74dopamine transport (GO:0015872)3.44782950
75carnitine metabolic process (GO:0009437)3.42478804
76tricarboxylic acid cycle (GO:0006099)3.42446548
77complement activation, alternative pathway (GO:0006957)3.40094034
78acyl-CoA metabolic process (GO:0006637)3.38976768
79thioester metabolic process (GO:0035383)3.38976768
80amine catabolic process (GO:0009310)3.37235495
81cellular biogenic amine catabolic process (GO:0042402)3.37235495
82positive regulation of fatty acid oxidation (GO:0046321)3.34371544
832-oxoglutarate metabolic process (GO:0006103)3.33598982
84very long-chain fatty acid metabolic process (GO:0000038)3.33260881
85cofactor catabolic process (GO:0051187)3.30921985
86establishment of protein localization to mitochondrial membrane (GO:0090151)3.30459161
87cytochrome complex assembly (GO:0017004)3.24324903
88negative regulation of fibrinolysis (GO:0051918)3.22779190
89cellular glucuronidation (GO:0052695)3.22177009
90response to phenylpropanoid (GO:0080184)3.22020215
91plasma lipoprotein particle clearance (GO:0034381)3.21771933
92regulation of protein activation cascade (GO:2000257)3.20874854
93negative regulation of lipase activity (GO:0060192)3.20845408
94acyl-CoA biosynthetic process (GO:0071616)3.20392324
95thioester biosynthetic process (GO:0035384)3.20392324
96biotin metabolic process (GO:0006768)3.19924438
97protein-lipid complex remodeling (GO:0034368)3.19551485
98macromolecular complex remodeling (GO:0034367)3.19551485
99plasma lipoprotein particle remodeling (GO:0034369)3.19551485
100carnitine shuttle (GO:0006853)3.19364324
101regulation of cholesterol esterification (GO:0010872)3.18193326
102reverse cholesterol transport (GO:0043691)3.17587257
103urea cycle (GO:0000050)3.17547253
104urea metabolic process (GO:0019627)3.17547253
105regulation of cholesterol metabolic process (GO:0090181)3.17414337
106indolalkylamine metabolic process (GO:0006586)3.16838963
107neuron fate determination (GO:0048664)3.16029996
108xenobiotic catabolic process (GO:0042178)3.14683006
109regulation of fibrinolysis (GO:0051917)3.13061550
110proteasome assembly (GO:0043248)3.10846425
111regulation of fatty acid oxidation (GO:0046320)3.10215606
112small molecule catabolic process (GO:0044282)3.09774734
113flavonoid metabolic process (GO:0009812)3.09534468
114benzene-containing compound metabolic process (GO:0042537)3.09318221
115response to mercury ion (GO:0046689)3.07814206
116nitrogen cycle metabolic process (GO:0071941)3.03385564
117quinone biosynthetic process (GO:1901663)3.02248942
118ubiquinone biosynthetic process (GO:0006744)3.02248942
119regulation of complement activation (GO:0030449)3.00341279
120regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.99872569
121negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.99738589
122positive regulation of fatty acid beta-oxidation (GO:0032000)2.98320527
123positive regulation of lipid catabolic process (GO:0050996)2.97789278
124regulation of acyl-CoA biosynthetic process (GO:0050812)2.89039429
125protein-cofactor linkage (GO:0018065)2.88447838
126cullin deneddylation (GO:0010388)2.88154556
127L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.84165310
128RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.82378218
129tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.82378218
130inositol phosphate catabolic process (GO:0071545)2.82035689
131chaperone-mediated protein transport (GO:0072321)2.78279105
132nonmotile primary cilium assembly (GO:0035058)2.78158371
133negative regulation of heart rate (GO:0010459)2.76623966
134preassembly of GPI anchor in ER membrane (GO:0016254)2.76618637
135proton transport (GO:0015992)2.76335350
136intraciliary transport (GO:0042073)2.75248574
137hydrogen ion transmembrane transport (GO:1902600)2.74412946
138hydrogen transport (GO:0006818)2.72980533
139regulation of neurotransmitter uptake (GO:0051580)2.72826783
140L-methionine salvage (GO:0071267)2.71707675
141L-methionine biosynthetic process (GO:0071265)2.71707675
142amino acid salvage (GO:0043102)2.71707675
143adenosine metabolic process (GO:0046085)2.71282314
144aggressive behavior (GO:0002118)2.63940982
145nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.62503087
146regulation of sulfur metabolic process (GO:0042762)2.62256633
147protein localization to cilium (GO:0061512)2.60378505
148positive regulation of glycolytic process (GO:0045821)2.60300294
149anterograde synaptic vesicle transport (GO:0048490)2.60096034
150exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.59456131
151signal peptide processing (GO:0006465)2.59070194
152regulation of cilium movement (GO:0003352)2.58094679
153regulation of meiosis I (GO:0060631)2.57873012
154inositol phosphate dephosphorylation (GO:0046855)2.54850962
155phosphorylated carbohydrate dephosphorylation (GO:0046838)2.54850962
156C-terminal protein lipidation (GO:0006501)2.54094323
157protein deneddylation (GO:0000338)2.53470261
158GPI anchor metabolic process (GO:0006505)2.52209743
159detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.50075847
160positive regulation of meiosis (GO:0045836)2.49963991
161lactate metabolic process (GO:0006089)2.49961898
162regulation of oxidative phosphorylation (GO:0002082)2.49921763
163C4-dicarboxylate transport (GO:0015740)2.47580995
164ATP biosynthetic process (GO:0006754)2.45381726
165epithelial cilium movement (GO:0003351)2.44994657
166retinal cone cell development (GO:0046549)2.44843029
167intracellular protein transmembrane import (GO:0044743)2.44784137
168negative regulation of appetite (GO:0032099)2.43660170
169negative regulation of response to food (GO:0032096)2.43660170
170positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.39028847
171cilium morphogenesis (GO:0060271)2.38485670
172nitric oxide mediated signal transduction (GO:0007263)2.37885069
173oxidative phosphorylation (GO:0006119)2.36267956
174regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.34136335
175neurotransmitter catabolic process (GO:0042135)2.32969701
176peroxisome fission (GO:0016559)2.31140262
177protein prenylation (GO:0018342)2.31073223
178prenylation (GO:0097354)2.31073223
179GPI anchor biosynthetic process (GO:0006506)2.30700052
180mannosylation (GO:0097502)2.30698489
181C-terminal protein amino acid modification (GO:0018410)2.29640605
182polyol catabolic process (GO:0046174)2.29538500
183regulation of cofactor metabolic process (GO:0051193)2.28784227
184regulation of coenzyme metabolic process (GO:0051196)2.28784227
185rRNA modification (GO:0000154)2.27543179
186positive regulation of mitochondrial fission (GO:0090141)2.27226244
187negative regulation of calcium ion transmembrane transport (GO:1903170)2.26743807
188negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.26743807
189nucleotide transmembrane transport (GO:1901679)2.26446773

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.32977317
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.68796023
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.75863358
4* EGR1_23403033_ChIP-Seq_LIVER_Mouse4.96724424
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.79673090
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.49232314
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.96276234
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.92194420
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.36574766
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.86575667
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.67198381
12IGF1R_20145208_ChIP-Seq_DFB_Human2.56111196
13ZNF274_21170338_ChIP-Seq_K562_Hela2.52502794
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.32353569
15FUS_26573619_Chip-Seq_HEK293_Human2.21448974
16EWS_26573619_Chip-Seq_HEK293_Human2.19090476
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17627370
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08479031
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02916787
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01959021
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98288253
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94698400
23HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.92522456
24ELK1_19687146_ChIP-ChIP_HELA_Human1.90442352
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78198612
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75407198
27* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.72108123
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.71573188
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68823111
30EZH2_22144423_ChIP-Seq_EOC_Human1.68164721
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.67082977
32HTT_18923047_ChIP-ChIP_STHdh_Human1.64615493
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.52064725
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.49725212
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48809099
36CLOCK_20551151_ChIP-Seq_293T_Human1.47042913
37NANOG_18555785_Chip-Seq_ESCs_Mouse1.46447401
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44992187
39NFE2_27457419_Chip-Seq_LIVER_Mouse1.44577762
40AR_25329375_ChIP-Seq_VCAP_Human1.43536287
41VDR_23849224_ChIP-Seq_CD4+_Human1.43024480
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43013615
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41507496
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39573903
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.38621810
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38404414
47NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38404414
48TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.38264769
49EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37946777
50P53_22387025_ChIP-Seq_ESCs_Mouse1.37716975
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34821808
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31428601
53TP53_22573176_ChIP-Seq_HFKS_Human1.30602972
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29901267
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.29304801
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27479136
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26410628
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24950798
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.23684005
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23682848
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23428769
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22954236
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20787843
64TCF4_22108803_ChIP-Seq_LS180_Human1.19564014
65MYC_18940864_ChIP-ChIP_HL60_Human1.18779352
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18487065
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.18466695
68GATA1_22025678_ChIP-Seq_K562_Human1.18420194
69E2F1_18555785_Chip-Seq_ESCs_Mouse1.17802419
70IRF8_22096565_ChIP-ChIP_GC-B_Human1.17776770
71STAT3_18555785_Chip-Seq_ESCs_Mouse1.16933441
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14552585
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.14552585
74EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14550821
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.14291453
76SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14191015
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13972932
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13727177
79FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13430043
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12741711
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12365155
82TCF4_23295773_ChIP-Seq_U87_Human1.11403283
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11264883
84STAT3_23295773_ChIP-Seq_U87_Human1.10864005
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.10499079
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10427495
87CMYC_18555785_Chip-Seq_ESCs_Mouse1.09665784
88RNF2_27304074_Chip-Seq_NSC_Mouse1.09377380
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09181448
90SOX2_18555785_Chip-Seq_ESCs_Mouse1.09008990
91P300_18555785_Chip-Seq_ESCs_Mouse1.08000442
92* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07725213
93TAF15_26573619_Chip-Seq_HEK293_Human1.05258336
94SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05048488
95SALL4_22934838_ChIP-ChIP_CD34+_Human1.04840145
96OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02969748
97RUNX2_22187159_ChIP-Seq_PCA_Human1.01702917
98CDX2_22108803_ChIP-Seq_LS180_Human1.01215048
99AR_20517297_ChIP-Seq_VCAP_Human1.01156577
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99769219
101CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99762316
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95819834
103Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95061435
104EGR1_19032775_ChIP-ChIP_M12_Human0.93819566
105PIAS1_25552417_ChIP-Seq_VCAP_Human0.92639513
106EP300_21415370_ChIP-Seq_HL-1_Mouse0.92208128
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89737391
108PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.88690880
109GBX2_23144817_ChIP-Seq_PC3_Human0.87374673
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83718025
111ERG_20517297_ChIP-Seq_VCAP_Human0.82994449
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82416484
113GATA2_21666600_ChIP-Seq_HMVEC_Human0.81887078
114SOX2_20726797_ChIP-Seq_SW620_Human0.81611283
115FOXA2_19822575_ChIP-Seq_HepG2_Human0.81036766
116CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.79601822
117SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78584635
118HNF4A_19822575_ChIP-Seq_HepG2_Human0.77962721
119PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.77513761
120FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.77450713
121ZFP57_27257070_Chip-Seq_ESCs_Mouse0.75913671
122KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75642993
123SOX2_27498859_Chip-Seq_STOMACH_Mouse0.75517496
124* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75460272
125FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74539865
126SOX2_19829295_ChIP-Seq_ESCs_Human0.74336645
127NANOG_19829295_ChIP-Seq_ESCs_Human0.74336645
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.73468642
129IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.72945345
130SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.70879813
131LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.70865508
132FLI1_27457419_Chip-Seq_LIVER_Mouse0.69393502
133RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69310472
134VDR_22108803_ChIP-Seq_LS180_Human0.68454965
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.68105411
136BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67811883
137CDX2_19796622_ChIP-Seq_MESCs_Mouse0.67063945
138ER_23166858_ChIP-Seq_MCF-7_Human0.67004364
139CBP_21632823_ChIP-Seq_H3396_Human0.65943855
140GATA4_25053715_ChIP-Seq_YYC3_Human0.65104426
141SUZ12_27294783_Chip-Seq_NPCs_Mouse0.64565920
142PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.64505244
143FOXA1_25552417_ChIP-Seq_VCAP_Human0.64198119
144AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.63669908
145CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.63233396
146CRX_20693478_ChIP-Seq_RETINA_Mouse0.63189904
147GABP_17652178_ChIP-ChIP_JURKAT_Human0.62536499
148CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.60459716
149RXRA_24833708_ChIP-Seq_LIVER_Mouse0.58938410
150EZH2_27294783_Chip-Seq_NPCs_Mouse0.58284025
151P300_19829295_ChIP-Seq_ESCs_Human0.57608402
152PCGF2_27294783_Chip-Seq_ESCs_Mouse0.57571944
153TAL1_26923725_Chip-Seq_HPCs_Mouse0.57097110
154UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.57018806
155BCAT_22108803_ChIP-Seq_LS180_Human0.57007392
156IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.56858969
157CBP_20019798_ChIP-Seq_JUKART_Human0.56858969
158OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.56214818
159ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.55321249
160TBX20_22080862_ChIP-Seq_HEART_Mouse0.55148679
161TBX20_22328084_ChIP-Seq_HEART_Mouse0.55148679
162CJUN_26792858_Chip-Seq_BT549_Human0.54587398
163SMAD1_18555785_Chip-Seq_ESCs_Mouse0.54081315

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.89382316
2MP0005360_urolithiasis5.60166047
3MP0005085_abnormal_gallbladder_physiolo4.96283625
4MP0005365_abnormal_bile_salt4.68867440
5MP0003806_abnormal_nucleotide_metabolis3.98013564
6MP0008875_abnormal_xenobiotic_pharmacok3.93558221
7MP0003195_calcinosis3.74635574
8MP0010329_abnormal_lipoprotein_level2.85004114
9MP0003252_abnormal_bile_duct2.83595016
10MP0005332_abnormal_amino_acid2.75094444
11MP0002837_dystrophic_cardiac_calcinosis2.58692335
12MP0009697_abnormal_copulation2.50259469
13MP0005670_abnormal_white_adipose2.42802877
14MP0008877_abnormal_DNA_methylation2.42439606
15MP0005646_abnormal_pituitary_gland2.34841530
16MP0006036_abnormal_mitochondrial_physio2.20299035
17MP0001529_abnormal_vocalization2.16249940
18MP0001666_abnormal_nutrient_absorption2.11443839
19MP0006072_abnormal_retinal_apoptosis2.08510895
20MP0004130_abnormal_muscle_cell2.05069812
21MP0002118_abnormal_lipid_homeostasis2.04787309
22MP0003646_muscle_fatigue2.03611669
23MP0005645_abnormal_hypothalamus_physiol2.00909151
24MP0003787_abnormal_imprinting2.00281915
25MP0005083_abnormal_biliary_tract1.99273738
26MP0005084_abnormal_gallbladder_morpholo1.98011345
27MP0003186_abnormal_redox_activity1.95201111
28MP0003880_abnormal_central_pattern1.92961648
29MP0003191_abnormal_cellular_cholesterol1.84915265
30MP0009046_muscle_twitch1.83535487
31MP0009840_abnormal_foam_cell1.82191576
32MP0002736_abnormal_nociception_after1.81620969
33MP0002638_abnormal_pupillary_reflex1.79310366
34MP0005584_abnormal_enzyme/coenzyme_acti1.79144964
35MP0005253_abnormal_eye_physiology1.79015342
36MP0001968_abnormal_touch/_nociception1.78099867
37MP0002909_abnormal_adrenal_gland1.77832497
38MP0005551_abnormal_eye_electrophysiolog1.76931527
39MP0003136_yellow_coat_color1.75326837
40MP0004142_abnormal_muscle_tone1.72962326
41MP0002138_abnormal_hepatobiliary_system1.71242239
42MP0002971_abnormal_brown_adipose1.69246998
43MP0000372_irregular_coat_pigmentation1.66367008
44MP0001764_abnormal_homeostasis1.66358700
45MP0000609_abnormal_liver_physiology1.65628168
46MP0002102_abnormal_ear_morphology1.64580211
47MP0005319_abnormal_enzyme/_coenzyme1.62463104
48MP0002272_abnormal_nervous_system1.61730262
49MP0005535_abnormal_body_temperature1.61548232
50MP0001905_abnormal_dopamine_level1.60781687
51MP0004019_abnormal_vitamin_homeostasis1.58199440
52MP0003868_abnormal_feces_composition1.57679353
53MP0009745_abnormal_behavioral_response1.54336824
54MP0005666_abnormal_adipose_tissue1.51929287
55MP0006276_abnormal_autonomic_nervous1.47563921
56MP0005379_endocrine/exocrine_gland_phen1.46200692
57MP0005330_cardiomyopathy1.46038607
58MP0002332_abnormal_exercise_endurance1.45923699
59MP0000631_abnormal_neuroendocrine_gland1.42508684
60MP0004270_analgesia1.41799186
61MP0000749_muscle_degeneration1.40764076
62MP0009643_abnormal_urine_homeostasis1.40678308
63MP0008872_abnormal_physiological_respon1.40443154
64MP0004145_abnormal_muscle_electrophysio1.40162881
65MP0001188_hyperpigmentation1.39663370
66MP0004885_abnormal_endolymph1.39137519
67MP0005167_abnormal_blood-brain_barrier1.39010372
68MP0000516_abnormal_urinary_system1.38387082
69MP0005367_renal/urinary_system_phenotyp1.38387082
70MP0001486_abnormal_startle_reflex1.38163388
71MP0008789_abnormal_olfactory_epithelium1.35844814
72MP0003122_maternal_imprinting1.32504041
73MP0003724_increased_susceptibility_to1.30184609
74MP0004043_abnormal_pH_regulation1.29672097
75MP0001485_abnormal_pinna_reflex1.29635293
76MP0003011_delayed_dark_adaptation1.29508414
77MP0008995_early_reproductive_senescence1.28790657
78MP0003121_genomic_imprinting1.26786133
79MP0002234_abnormal_pharynx_morphology1.24843511
80MP0006292_abnormal_olfactory_placode1.21326800
81MP0004147_increased_porphyrin_level1.20463148
82MP0002090_abnormal_vision1.19189185
83MP0008058_abnormal_DNA_repair1.18786564
84MP0002078_abnormal_glucose_homeostasis1.17784999
85MP0002938_white_spotting1.17761495
86MP0002876_abnormal_thyroid_physiology1.15148705
87MP0005451_abnormal_body_composition1.13387933
88MP0002064_seizures1.12494138
89MP0005248_abnormal_Harderian_gland1.12372476
90MP0002572_abnormal_emotion/affect_behav1.10384689
91MP0010368_abnormal_lymphatic_system1.09189810
92MP0004036_abnormal_muscle_relaxation1.08726101
93MP0006035_abnormal_mitochondrial_morpho1.06745590
94MP0005187_abnormal_penis_morphology1.06492388
95MP0003786_premature_aging1.06185590
96MP0005636_abnormal_mineral_homeostasis1.05948126
97MP0001970_abnormal_pain_threshold1.05440656
98MP0005266_abnormal_metabolism1.04506323
99MP0009764_decreased_sensitivity_to1.04051535
100MP0003656_abnormal_erythrocyte_physiolo1.03784804
101MP0003221_abnormal_cardiomyocyte_apopto1.03688993
102MP0010386_abnormal_urinary_bladder1.03167482
103MP0002734_abnormal_mechanical_nocicepti1.02585724
104MP0005334_abnormal_fat_pad1.02349280
105MP0003690_abnormal_glial_cell1.01324015
106MP0003633_abnormal_nervous_system1.00834611
107MP0003950_abnormal_plasma_membrane0.99742964
108MP0001944_abnormal_pancreas_morphology0.99643230
109MP0002067_abnormal_sensory_capabilities0.97990228
110MP0000230_abnormal_systemic_arterial0.96850608
111MP0009780_abnormal_chondrocyte_physiolo0.96615653
112MP0003718_maternal_effect0.94450378
113MP0003635_abnormal_synaptic_transmissio0.94269072
114MP0004924_abnormal_behavior0.94134677
115MP0005386_behavior/neurological_phenoty0.94134677
116MP0005376_homeostasis/metabolism_phenot0.93420185
117MP0004085_abnormal_heartbeat0.93160331
118MP0002733_abnormal_thermal_nociception0.90831249
119MP0002557_abnormal_social/conspecific_i0.89696714
120MP0004133_heterotaxia0.87924630
121MP0005448_abnormal_energy_balance0.86766460
122MP0005220_abnormal_exocrine_pancreas0.85563062
123MP0002693_abnormal_pancreas_physiology0.84807318
124MP0000639_abnormal_adrenal_gland0.84240253
125MP0002972_abnormal_cardiac_muscle0.84102858
126MP0005171_absent_coat_pigmentation0.83760253
127MP0001853_heart_inflammation0.82187930
128MP0005620_abnormal_muscle_contractility0.81716621
129MP0005647_abnormal_sex_gland0.81523347
130MP0009763_increased_sensitivity_to0.81313489
131MP0009642_abnormal_blood_homeostasis0.81222211
132MP0008469_abnormal_protein_level0.80754565
133MP0004185_abnormal_adipocyte_glucose0.80678905
134MP0002822_catalepsy0.80544355
135MP0005375_adipose_tissue_phenotype0.80019134
136MP0001879_abnormal_lymphatic_vessel0.79450279
137MP0000598_abnormal_liver_morphology0.78620036
138MP0005408_hypopigmentation0.78362247
139MP0000013_abnormal_adipose_tissue0.76522873
140MP0004215_abnormal_myocardial_fiber0.76501057
141MP0008775_abnormal_heart_ventricle0.74846570
142MP0001756_abnormal_urination0.70206973
143MP0004381_abnormal_hair_follicle0.69231271
144MP0005595_abnormal_vascular_smooth0.67145808
145MP0002970_abnormal_white_adipose0.66799322
146MP0005385_cardiovascular_system_phenoty0.65270709
147MP0001544_abnormal_cardiovascular_syste0.65270709
148MP0004084_abnormal_cardiac_muscle0.64927649
149MP0009765_abnormal_xenobiotic_induced0.63480505
150MP0001661_extended_life_span0.62012653
151MP0001984_abnormal_olfaction0.59006646
152MP0000343_altered_response_to0.56783415
153MP0003953_abnormal_hormone_level0.56500588
154MP0006138_congestive_heart_failure0.56430912
155MP0002877_abnormal_melanocyte_morpholog0.55787600
156MP0000747_muscle_weakness0.54756094
157MP0009379_abnormal_foot_pigmentation0.53828930
158MP0005165_increased_susceptibility_to0.53323416
159MP0004484_altered_response_of0.52435641
160MP0003137_abnormal_impulse_conducting0.51163501
161MP0004087_abnormal_muscle_fiber0.50169135
162MP0005058_abnormal_lysosome_morphology0.49750783
163MP0003959_abnormal_lean_body0.47662955
164MP0000751_myopathy0.45978644
165MP0000920_abnormal_myelination0.45504611

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.13808466
2Hypoglycemic coma (HP:0001325)4.80470543
3Abnormality of fatty-acid metabolism (HP:0004359)4.31687505
4Cerebral edema (HP:0002181)4.31047932
5Acute encephalopathy (HP:0006846)4.29885996
6Hepatic necrosis (HP:0002605)4.26113539
7Acute necrotizing encephalopathy (HP:0006965)4.24616609
8Intrahepatic cholestasis (HP:0001406)4.23556711
9Abnormal mitochondria in muscle tissue (HP:0008316)4.16941872
10Hyperglycinuria (HP:0003108)3.98611372
11Ketosis (HP:0001946)3.97379041
12Xanthomatosis (HP:0000991)3.89724791
13Prolonged partial thromboplastin time (HP:0003645)3.87625250
14Abnormality of dicarboxylic acid metabolism (HP:0010995)3.85728411
15Dicarboxylic aciduria (HP:0003215)3.85728411
16Abnormality of serine family amino acid metabolism (HP:0010894)3.85463970
17Abnormality of glycine metabolism (HP:0010895)3.85463970
18Hyperammonemia (HP:0001987)3.81970372
19Generalized aminoaciduria (HP:0002909)3.80573443
20Hyperglycinemia (HP:0002154)3.72170355
21Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.60346076
22Ketoacidosis (HP:0001993)3.56731998
23Hypobetalipoproteinemia (HP:0003563)3.54540364
24Myoglobinuria (HP:0002913)3.53934039
25Hepatocellular necrosis (HP:0001404)3.52940113
26Progressive macrocephaly (HP:0004481)3.52812282
27Deep venous thrombosis (HP:0002625)3.46526182
28Hyperlipoproteinemia (HP:0010980)3.45729120
29Increased hepatocellular lipid droplets (HP:0006565)3.42040530
30Lethargy (HP:0001254)3.38572625
31Abnormality of monocarboxylic acid metabolism (HP:0010996)3.33327494
32Mitochondrial inheritance (HP:0001427)3.28716087
33Abnormality of serum amino acid levels (HP:0003112)3.19675378
34Abnormality of aspartate family amino acid metabolism (HP:0010899)3.16361966
35Increased CSF lactate (HP:0002490)3.10353346
36Renal Fanconi syndrome (HP:0001994)3.07846823
37Lactic acidosis (HP:0003128)3.02622761
38Joint hemorrhage (HP:0005261)3.01293454
39Hypolipoproteinemia (HP:0010981)3.00357353
40Metabolic acidosis (HP:0001942)3.00061321
41Medial flaring of the eyebrow (HP:0010747)2.99405669
42Abnormality of glycolysis (HP:0004366)2.95564201
43Increased serum pyruvate (HP:0003542)2.95564201
44Hypoalphalipoproteinemia (HP:0003233)2.88776890
45Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.87180643
46Renal cortical cysts (HP:0000803)2.84178964
47Proximal tubulopathy (HP:0000114)2.82475245
48Increased muscle lipid content (HP:0009058)2.81822452
49Abnormality of glutamine family amino acid metabolism (HP:0010902)2.80504665
50Abnormality of the intrinsic pathway (HP:0010989)2.79554007
51Complement deficiency (HP:0004431)2.78638884
52Abnormality of methionine metabolism (HP:0010901)2.75670956
53Pancreatic fibrosis (HP:0100732)2.75043551
54Vomiting (HP:0002013)2.69556447
55Delayed CNS myelination (HP:0002188)2.68656584
56Hypothermia (HP:0002045)2.67074225
57Epidermoid cyst (HP:0200040)2.66138822
58Abnormality of the common coagulation pathway (HP:0010990)2.64919794
59Ragged-red muscle fibers (HP:0003200)2.64053306
60Pancreatic cysts (HP:0001737)2.63912241
61Hypercholesterolemia (HP:0003124)2.57373577
62Glycosuria (HP:0003076)2.57287545
63Abnormality of urine glucose concentration (HP:0011016)2.57287545
64Fat malabsorption (HP:0002630)2.56584929
65Conjugated hyperbilirubinemia (HP:0002908)2.56020193
66Methylmalonic aciduria (HP:0012120)2.55031918
67Congenital, generalized hypertrichosis (HP:0004540)2.54109032
68Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53692143
69Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53692143
70True hermaphroditism (HP:0010459)2.53322544
71Abnormality of vitamin B metabolism (HP:0004340)2.50897728
72Exertional dyspnea (HP:0002875)2.50711859
73Rhabdomyolysis (HP:0003201)2.47218859
74Respiratory failure (HP:0002878)2.43879571
75Abnormality of midbrain morphology (HP:0002418)2.41044486
76Molar tooth sign on MRI (HP:0002419)2.41044486
77Lipid accumulation in hepatocytes (HP:0006561)2.40663309
78Hypoglycemic seizures (HP:0002173)2.39684830
79Nausea (HP:0002018)2.39409422
80Abnormality of the renal cortex (HP:0011035)2.39174388
81Gait imbalance (HP:0002141)2.39086716
82Congenital primary aphakia (HP:0007707)2.37965941
83Hyperinsulinemic hypoglycemia (HP:0000825)2.37828488
84Increased intramyocellular lipid droplets (HP:0012240)2.36714445
85Nephronophthisis (HP:0000090)2.35692372
86Methylmalonic acidemia (HP:0002912)2.34164579
87Abnormality of sulfur amino acid metabolism (HP:0004339)2.33841863
88Large for gestational age (HP:0001520)2.32431183
89Hyperphosphaturia (HP:0003109)2.32087188
90Abolished electroretinogram (ERG) (HP:0000550)2.30831074
91Hyperbilirubinemia (HP:0002904)2.29825437
92Abnormality of alanine metabolism (HP:0010916)2.27216431
93Hyperalaninemia (HP:0003348)2.27216431
94Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27216431
95Nephrogenic diabetes insipidus (HP:0009806)2.26607677
96Exercise intolerance (HP:0003546)2.26411778
97Exercise-induced muscle cramps (HP:0003710)2.25436917
98Leukodystrophy (HP:0002415)2.25340075
99Pancreatitis (HP:0001733)2.22559364
100Respiratory distress (HP:0002098)2.21767022
101Calf muscle hypertrophy (HP:0008981)2.19438036
102Optic disc pallor (HP:0000543)2.18992118
103Palpitations (HP:0001962)2.18697819
104Increased serum lactate (HP:0002151)2.15869270
105Neuroendocrine neoplasm (HP:0100634)2.15211711
106Abnormality of the vitamin B12 metabolism (HP:0004341)2.14370420
107Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08482389
108Abnormality of renal resorption (HP:0011038)2.05654684
109Abnormality of the renal medulla (HP:0100957)2.05338954
110Steatorrhea (HP:0002570)2.04377290
111Hemiparesis (HP:0001269)2.04249123
112Muscle hypertrophy of the lower extremities (HP:0008968)2.03154147
1133-Methylglutaconic aciduria (HP:0003535)2.02732022
114Abnormality of purine metabolism (HP:0004352)2.00324706
115Hypomagnesemia (HP:0002917)1.97058009
116Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95776529
117Intestinal atresia (HP:0011100)1.95745399
118Cerebral palsy (HP:0100021)1.95264602
119Hyperglycemia (HP:0003074)1.95020255
120Symptomatic seizures (HP:0011145)1.94648831
121Genital tract atresia (HP:0001827)1.93098342
122Congenital stationary night blindness (HP:0007642)1.92539287
123Abnormality of complement system (HP:0005339)1.91419523
124Oligomenorrhea (HP:0000876)1.91049574
125Abnormality of proline metabolism (HP:0010907)1.90857378
126Hydroxyprolinuria (HP:0003080)1.90857378
127Abnormal gallbladder morphology (HP:0012437)1.90193489
128Spastic paraparesis (HP:0002313)1.88644253
129Elevated hepatic transaminases (HP:0002910)1.87633363
130Abnormality of nucleobase metabolism (HP:0010932)1.86374064
131CNS demyelination (HP:0007305)1.85514721
132Brushfield spots (HP:0001088)1.85134243
133Median cleft lip (HP:0000161)1.79571620
134Febrile seizures (HP:0002373)1.76404696
135Abnormal drinking behavior (HP:0030082)1.76146546
136Polydipsia (HP:0001959)1.76146546
137Abnormality of vitamin metabolism (HP:0100508)1.75402218
138Neoplasm of the adrenal gland (HP:0100631)1.75178873
139Vaginal atresia (HP:0000148)1.74884462
140Male pseudohermaphroditism (HP:0000037)1.73092284
141Abnormality of the fovea (HP:0000493)1.72225084
142Hypoplasia of the fovea (HP:0007750)1.70390703
143Aplasia/Hypoplasia of the fovea (HP:0008060)1.70390703
144Pheochromocytoma (HP:0002666)1.69955745
145Left ventricular hypertrophy (HP:0001712)1.69687696
146Limb dystonia (HP:0002451)1.69249099
147Aplasia/Hypoplasia of the tongue (HP:0010295)1.68390881
148Focal motor seizures (HP:0011153)1.65999530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.43024414
2MAP4K22.71646465
3PINK12.60206110
4MUSK2.57964774
5NME22.39084927
6NEK92.38601402
7MYLK2.35253382
8MST1R2.28270730
9IRAK32.24779652
10INSRR2.17784627
11PDK42.10138054
12PDK32.10138054
13OBSCN2.04604196
14TIE11.95584830
15PLK21.85328107
16STK38L1.84042185
17STK161.77725911
18MAP3K41.76913231
19PIK3CG1.75940741
20PBK1.71854542
21PNCK1.60965806
22SIK11.55929653
23MAPK151.55025180
24CSNK1G21.50515704
25EIF2AK11.49494820
26PDK21.49246851
27PIK3CA1.47742796
28FGFR41.47552569
29IRAK11.45494406
30FLT31.43620887
31GRK71.42664811
32STK391.40732210
33TRIM281.40368101
34VRK11.40074897
35CSNK1G31.39142864
36WNK41.38488423
37EIF2AK31.27618410
38MAPK131.24704462
39MAP3K141.21959839
40PHKG11.21794922
41PHKG21.21794922
42VRK21.21466969
43TGFBR21.20478380
44FER1.16501862
45MST41.14264038
46MAP3K121.10030986
47PAK31.08536806
48PLK31.07842614
49IRAK41.05485451
50BMPR1B1.04994843
51ERN11.02445403
52OXSR11.00455613
53CCNB10.95414303
54GRK10.95336739
55NTRK30.93484259
56MAP2K70.92671741
57ERBB40.91539333
58CASK0.91122668
59STK240.90265800
60CSNK1A1L0.89570452
61MARK10.89257417
62MAP2K40.89002850
63IRAK20.88506420
64TNIK0.87250324
65DYRK20.86881153
66PRKAA20.85059084
67MKNK20.84748734
68ABL20.82437691
69TEC0.81806275
70EPHA40.80931011
71BMPR20.80065549
72PKN10.79756068
73DAPK20.79528538
74PRKCG0.79178701
75CAMK2G0.77382625
76SGK4940.76828014
77SGK2230.76828014
78AKT30.75232466
79FRK0.74617700
80MET0.73801916
81CAMK2D0.73443014
82NUAK10.73081484
83MKNK10.72516609
84EPHB10.70562486
85NEK10.68613016
86EPHA30.64959758
87GRK50.63602455
88STK30.63054435
89LIMK10.63023714
90ERBB30.62188579
91TLK10.60663140
92PRKCE0.60509652
93MINK10.60096582
94CAMKK20.59532202
95MAPK40.56921985
96PRKACG0.56062279
97PRKG10.55302889
98PTK2B0.55068641
99SGK20.54247437
100CSNK1G10.54032496
101WEE10.53963015
102MAP3K30.53773617
103MAPKAPK30.53705658
104FGFR20.52410159
105ADRBK10.52056913
106RPS6KA50.50110439
107ADRBK20.49691819
108BCR0.48881783
109YES10.48407979
110MAP3K50.48381833
111GSK3A0.48170686
112NLK0.47736727
113TAOK30.47053318
114WNK30.46674405
115DYRK30.46106471
116PRKCQ0.45427965
117CSNK1A10.45207242
118JAK20.44020868
119NME10.43500938
120PRKACA0.43405483
121MAPKAPK50.42821325
122CAMK2B0.42332847
123CAMK2A0.42328015
124ROCK10.41540046
125CDK30.41400831
126CSK0.40862481
127LMTK20.40714662
128PIM20.39431787
129MAPK110.37831535
130JAK10.37686139
131NTRK20.37661950
132PRKAA10.37153199
133TNK20.36858299
134CAMK10.36729326
135TXK0.36472099
136MAPK70.36309734
137BRSK20.36294607
138IGF1R0.35644670
139TYK20.35368956
140ACVR1B0.34992081
141TBK10.34069950
142PRKACB0.33517893
143ZAK0.32888113
144PDPK10.32796845
145PLK40.31964562
146IKBKE0.31075298
147MAP2K60.30477833

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.25138932
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.24048096
3Fatty acid degradation_Homo sapiens_hsa000713.10757735
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.05466717
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71952889
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62680295
7Fatty acid elongation_Homo sapiens_hsa000622.55278123
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.50773404
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.50180505
10Fatty acid metabolism_Homo sapiens_hsa012122.45901685
11Butanoate metabolism_Homo sapiens_hsa006502.30699805
12Tryptophan metabolism_Homo sapiens_hsa003802.26665008
13Sulfur metabolism_Homo sapiens_hsa009202.25690973
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.24793414
15Peroxisome_Homo sapiens_hsa041462.24423371
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.08206878
17PPAR signaling pathway_Homo sapiens_hsa033202.07401481
18Nitrogen metabolism_Homo sapiens_hsa009102.05242106
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04888108
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.01129606
21Oxidative phosphorylation_Homo sapiens_hsa001901.98691792
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.97270616
23Pyruvate metabolism_Homo sapiens_hsa006201.88422301
24Arginine biosynthesis_Homo sapiens_hsa002201.88303435
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.80450035
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.79223057
27beta-Alanine metabolism_Homo sapiens_hsa004101.73039811
28Parkinsons disease_Homo sapiens_hsa050121.71999069
29Complement and coagulation cascades_Homo sapiens_hsa046101.68554040
30Collecting duct acid secretion_Homo sapiens_hsa049661.62137239
31Carbon metabolism_Homo sapiens_hsa012001.60006142
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.54989718
33Chemical carcinogenesis_Homo sapiens_hsa052041.54857258
34Histidine metabolism_Homo sapiens_hsa003401.54479135
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49829788
36Caffeine metabolism_Homo sapiens_hsa002321.47017821
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45565572
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.45447568
39Retinol metabolism_Homo sapiens_hsa008301.37974878
40Phototransduction_Homo sapiens_hsa047441.32931750
41Protein export_Homo sapiens_hsa030601.31524492
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.31425825
43Folate biosynthesis_Homo sapiens_hsa007901.30593029
44Starch and sucrose metabolism_Homo sapiens_hsa005001.28390672
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.27902466
46Basal transcription factors_Homo sapiens_hsa030221.24510747
47Tyrosine metabolism_Homo sapiens_hsa003501.23561386
48Phenylalanine metabolism_Homo sapiens_hsa003601.20996554
49Alzheimers disease_Homo sapiens_hsa050101.17476217
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16743552
51Homologous recombination_Homo sapiens_hsa034401.15755911
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13881365
53Steroid biosynthesis_Homo sapiens_hsa001001.09478676
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09178996
55GABAergic synapse_Homo sapiens_hsa047271.06676216
56RNA polymerase_Homo sapiens_hsa030201.06018640
57Selenocompound metabolism_Homo sapiens_hsa004501.05568794
58Fanconi anemia pathway_Homo sapiens_hsa034601.04378841
59RNA degradation_Homo sapiens_hsa030181.03423630
60Nicotine addiction_Homo sapiens_hsa050330.97258336
61Huntingtons disease_Homo sapiens_hsa050160.93889576
62Staphylococcus aureus infection_Homo sapiens_hsa051500.92040583
63Fat digestion and absorption_Homo sapiens_hsa049750.91813162
64Arginine and proline metabolism_Homo sapiens_hsa003300.89905629
65Biosynthesis of amino acids_Homo sapiens_hsa012300.89887243
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85684277
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83316256
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83176960
69ABC transporters_Homo sapiens_hsa020100.82830711
70Serotonergic synapse_Homo sapiens_hsa047260.80066114
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.79813211
72Metabolic pathways_Homo sapiens_hsa011000.79117693
73Glutathione metabolism_Homo sapiens_hsa004800.77597804
74Bile secretion_Homo sapiens_hsa049760.77386160
75Insulin secretion_Homo sapiens_hsa049110.76624523
76Vitamin B6 metabolism_Homo sapiens_hsa007500.76124041
77Circadian entrainment_Homo sapiens_hsa047130.76067132
78Fatty acid biosynthesis_Homo sapiens_hsa000610.76037153
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72696294
80Ribosome_Homo sapiens_hsa030100.69114794
81Glycerolipid metabolism_Homo sapiens_hsa005610.68980259
82Olfactory transduction_Homo sapiens_hsa047400.68795386
83Sulfur relay system_Homo sapiens_hsa041220.68560652
84Morphine addiction_Homo sapiens_hsa050320.68072938
85Purine metabolism_Homo sapiens_hsa002300.67863969
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63705776
87Synaptic vesicle cycle_Homo sapiens_hsa047210.63188524
88Mismatch repair_Homo sapiens_hsa034300.62257266
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61855063
90Dopaminergic synapse_Homo sapiens_hsa047280.61624706
91Vitamin digestion and absorption_Homo sapiens_hsa049770.61304752
92Amphetamine addiction_Homo sapiens_hsa050310.60985915
93Renin secretion_Homo sapiens_hsa049240.59640178
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56259895
95Cardiac muscle contraction_Homo sapiens_hsa042600.55232953
96Asthma_Homo sapiens_hsa053100.51904885
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49275088
98Glutamatergic synapse_Homo sapiens_hsa047240.48883624
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.48556597
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48265081
101Pentose phosphate pathway_Homo sapiens_hsa000300.47568018
102Taste transduction_Homo sapiens_hsa047420.47481188
103One carbon pool by folate_Homo sapiens_hsa006700.45755614
104Cocaine addiction_Homo sapiens_hsa050300.45633162
105Nucleotide excision repair_Homo sapiens_hsa034200.45162303
106Galactose metabolism_Homo sapiens_hsa000520.42188809
107Type I diabetes mellitus_Homo sapiens_hsa049400.40868088
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.38427129
109Non-homologous end-joining_Homo sapiens_hsa034500.38378495
110Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.37675412
111Long-term depression_Homo sapiens_hsa047300.37272671
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36446158
113Oocyte meiosis_Homo sapiens_hsa041140.35904698
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34216647
115Fructose and mannose metabolism_Homo sapiens_hsa000510.31321969
116Linoleic acid metabolism_Homo sapiens_hsa005910.30349269
117Lysine degradation_Homo sapiens_hsa003100.25388439
118Insulin resistance_Homo sapiens_hsa049310.25369294
119Arachidonic acid metabolism_Homo sapiens_hsa005900.24990951
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24691976
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21330604
122Glucagon signaling pathway_Homo sapiens_hsa049220.20265742
123Regulation of autophagy_Homo sapiens_hsa041400.17579049
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.14964164
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.09280995
126Sphingolipid metabolism_Homo sapiens_hsa006000.08228585
127Insulin signaling pathway_Homo sapiens_hsa049100.06280421
128Ether lipid metabolism_Homo sapiens_hsa005650.06156655
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.04844307
130Other glycan degradation_Homo sapiens_hsa005110.04283473
131AMPK signaling pathway_Homo sapiens_hsa041520.03295220
132Ovarian steroidogenesis_Homo sapiens_hsa049130.01670723
133Prion diseases_Homo sapiens_hsa050200.01427690
134Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0925417
135Circadian rhythm_Homo sapiens_hsa04710-0.0661913
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0407120
137Proteasome_Homo sapiens_hsa03050-0.0311178

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