LYRM7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Inner mitochondrial membrane complex III (CIII) is the main enzyme complex in the mitochondrial respiratory chain, and Rieske Fe-S protein (UQCRFS1) is the last catalytic subunit added to the complex. The protein encoded by this gene is a nuclear-encoded mitochondrial matrix protein that stabilizes UQCRFS1 and chaperones it to the CIII complex. Defects in this gene are a cause of mitochondrial complex III deficiency, nuclear type 8. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.23627589
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.91739381
3ATP synthesis coupled proton transport (GO:0015986)5.91739381
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.53586455
5respiratory electron transport chain (GO:0022904)5.04342992
6electron transport chain (GO:0022900)4.91741595
7regulation of acyl-CoA biosynthetic process (GO:0050812)4.63620723
8negative regulation of synaptic transmission, GABAergic (GO:0032229)4.44161678
9tricarboxylic acid cycle (GO:0006099)4.41003256
10cellular ketone body metabolic process (GO:0046950)4.30194300
11regulation of cofactor metabolic process (GO:0051193)4.24046667
12regulation of coenzyme metabolic process (GO:0051196)4.24046667
13regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.20069314
14oxidative phosphorylation (GO:0006119)4.15974257
15synaptic vesicle exocytosis (GO:0016079)4.13932095
16neuron cell-cell adhesion (GO:0007158)4.08883397
17vocalization behavior (GO:0071625)3.92300343
18ketone body metabolic process (GO:1902224)3.88711867
19NADH metabolic process (GO:0006734)3.88337794
20protein complex biogenesis (GO:0070271)3.84932760
21behavioral response to nicotine (GO:0035095)3.77645498
22respiratory chain complex IV assembly (GO:0008535)3.76820271
23energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.74222212
24ATP hydrolysis coupled proton transport (GO:0015991)3.74222212
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.70430664
26NADH dehydrogenase complex assembly (GO:0010257)3.70430664
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.70430664
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.65247181
29ATP biosynthetic process (GO:0006754)3.64460622
30neuronal action potential propagation (GO:0019227)3.62081654
31presynaptic membrane assembly (GO:0097105)3.61664951
32inositol phosphate catabolic process (GO:0071545)3.59901987
33protein localization to synapse (GO:0035418)3.56877523
34glutamate secretion (GO:0014047)3.55340542
35mitochondrial respiratory chain complex assembly (GO:0033108)3.53644773
36ubiquinone biosynthetic process (GO:0006744)3.51158138
37presynaptic membrane organization (GO:0097090)3.48129649
38negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.47270451
39L-fucose catabolic process (GO:0042355)3.45728079
40fucose catabolic process (GO:0019317)3.45728079
41L-fucose metabolic process (GO:0042354)3.45728079
42regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.42538955
43hydrogen ion transmembrane transport (GO:1902600)3.40845510
44chaperone-mediated protein transport (GO:0072321)3.39577293
45water-soluble vitamin biosynthetic process (GO:0042364)3.39396459
46regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.36544472
47mitochondrial genome maintenance (GO:0000002)3.32988515
48L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.30033877
49positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.29631930
50cytochrome complex assembly (GO:0017004)3.27343161
51neuron-neuron synaptic transmission (GO:0007270)3.27114784
52ubiquinone metabolic process (GO:0006743)3.24697426
53regulation of glutamate secretion (GO:0014048)3.20711551
54response to pheromone (GO:0019236)3.19437475
55kynurenine metabolic process (GO:0070189)3.19314306
56DNA deamination (GO:0045006)3.19199059
57neurotransmitter-gated ion channel clustering (GO:0072578)3.18341326
58phosphorylated carbohydrate dephosphorylation (GO:0046838)3.18002690
59inositol phosphate dephosphorylation (GO:0046855)3.18002690
60glutamate receptor signaling pathway (GO:0007215)3.17580739
61regulation of mitochondrial translation (GO:0070129)3.16305812
62purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.15951730
63purine nucleoside triphosphate biosynthetic process (GO:0009145)3.15601168
64regulation of glutamate receptor signaling pathway (GO:1900449)3.13656790
65ionotropic glutamate receptor signaling pathway (GO:0035235)3.09093353
66peptidyl-histidine modification (GO:0018202)3.09031878
67membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08873246
68regulation of sulfur metabolic process (GO:0042762)3.08536976
69regulation of short-term neuronal synaptic plasticity (GO:0048172)3.07921155
70protein K6-linked ubiquitination (GO:0085020)3.07773019
71gamma-aminobutyric acid signaling pathway (GO:0007214)3.07570113
72calcium ion-dependent exocytosis (GO:0017156)3.05307740
73regulation of cell communication by electrical coupling (GO:0010649)3.04305880
74regulation of hexokinase activity (GO:1903299)3.04123800
75regulation of glucokinase activity (GO:0033131)3.04123800
76polyol catabolic process (GO:0046174)3.03880704
77regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.01549528
78proton transport (GO:0015992)3.00214611
79signal peptide processing (GO:0006465)3.00027310
80replication fork processing (GO:0031297)2.99776663
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.97631899
82synaptic vesicle docking involved in exocytosis (GO:0016081)2.97138147
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.95322974
84striatum development (GO:0021756)2.95069948
85hydrogen transport (GO:0006818)2.94610466
86synaptic transmission, glutamatergic (GO:0035249)2.94172426
87detection of calcium ion (GO:0005513)2.93924505
88regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.93835604
89behavioral response to cocaine (GO:0048148)2.93107608
90positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.92624238
91protein neddylation (GO:0045116)2.91568209
92long-term synaptic potentiation (GO:0060291)2.91241913
93protein-cofactor linkage (GO:0018065)2.90455638
94preassembly of GPI anchor in ER membrane (GO:0016254)2.88540889
95regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.87129162
96transferrin transport (GO:0033572)2.86871895
97positive regulation of synapse maturation (GO:0090129)2.85778477
98cullin deneddylation (GO:0010388)2.85496401
99regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.84674128
100postsynaptic membrane organization (GO:0001941)2.84578404
101regulation of synaptic vesicle exocytosis (GO:2000300)2.84315604
102L-methionine salvage (GO:0071267)2.83633072
103L-methionine biosynthetic process (GO:0071265)2.83633072
104amino acid salvage (GO:0043102)2.83633072
105indolalkylamine metabolic process (GO:0006586)2.83492222
106acrosome reaction (GO:0007340)2.81023594
107quinone biosynthetic process (GO:1901663)2.80487173
108positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.80476467
109DNA double-strand break processing (GO:0000729)2.79854089
110negative regulation of dendrite morphogenesis (GO:0050774)2.77153052
111negative regulation of cytosolic calcium ion concentration (GO:0051481)2.76730834
112gamma-aminobutyric acid transport (GO:0015812)2.75805174
113ribonucleoside triphosphate biosynthetic process (GO:0009201)2.75104069
114protein prenylation (GO:0018342)2.74462203
115prenylation (GO:0097354)2.74462203
116calcium-mediated signaling using intracellular calcium source (GO:0035584)2.74349959
117response to histamine (GO:0034776)2.74171300
118methionine biosynthetic process (GO:0009086)2.71916465
119retinal cone cell development (GO:0046549)2.71505128
120tryptophan catabolic process (GO:0006569)2.71378379
121indole-containing compound catabolic process (GO:0042436)2.71378379
122indolalkylamine catabolic process (GO:0046218)2.71378379
123rRNA catabolic process (GO:0016075)2.71222003
124detection of light stimulus involved in visual perception (GO:0050908)2.70908471
125detection of light stimulus involved in sensory perception (GO:0050962)2.70908471
126maturation of 5.8S rRNA (GO:0000460)2.70294413
127mechanosensory behavior (GO:0007638)2.69347942
128cerebellar granule cell differentiation (GO:0021707)2.69110521
129aerobic respiration (GO:0009060)2.68833927
130S-adenosylmethionine metabolic process (GO:0046500)2.68216546
131neurotransmitter secretion (GO:0007269)2.67645038
132negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.66409347
133female mating behavior (GO:0060180)2.66250921
134negative regulation of DNA-dependent DNA replication (GO:2000104)2.65948857
135regulation of cilium movement (GO:0003352)2.65657817
136regulation of excitatory postsynaptic membrane potential (GO:0060079)2.64995409
137regulation of synapse maturation (GO:0090128)2.64942314
138recombinational repair (GO:0000725)2.64344663
139double-strand break repair via homologous recombination (GO:0000724)2.64262093
140regulation of voltage-gated calcium channel activity (GO:1901385)2.64122304
141proline transport (GO:0015824)2.63300119
142succinate metabolic process (GO:0006105)2.63142963
143protein K11-linked deubiquitination (GO:0035871)2.62168987
144negative regulation of cation channel activity (GO:2001258)2.61466373
145trivalent inorganic cation transport (GO:0072512)2.60590439
146ferric iron transport (GO:0015682)2.60590439
147neuron recognition (GO:0008038)2.60521953
148reciprocal meiotic recombination (GO:0007131)2.60304988
149reciprocal DNA recombination (GO:0035825)2.60304988
150positive regulation of glycolytic process (GO:0045821)2.60258510
151neurotransmitter uptake (GO:0001504)2.60177386
152tryptophan metabolic process (GO:0006568)2.59232094
153regulation of synaptic vesicle transport (GO:1902803)2.58934404
154positive regulation of mitochondrial fission (GO:0090141)2.58490646
155C4-dicarboxylate transport (GO:0015740)2.58001356
156RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.57971448
157behavioral fear response (GO:0001662)2.57646515
158behavioral defense response (GO:0002209)2.57646515
159nucleoside triphosphate biosynthetic process (GO:0009142)2.57130380
160branched-chain amino acid catabolic process (GO:0009083)2.56363859
161nonmotile primary cilium assembly (GO:0035058)2.54703898
162axoneme assembly (GO:0035082)2.52206770
163neural tube formation (GO:0001841)2.46317744
164platelet dense granule organization (GO:0060155)2.45921097
165regulation of nuclear cell cycle DNA replication (GO:0033262)2.45032080
166pseudouridine synthesis (GO:0001522)2.42466691
167neuronal action potential (GO:0019228)2.41265701
168magnesium ion transport (GO:0015693)2.39652453
169auditory receptor cell stereocilium organization (GO:0060088)2.38891565
170exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.36210284
171nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.35474229
172epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.34037192
173rRNA methylation (GO:0031167)2.33485588
174cAMP catabolic process (GO:0006198)2.32799586
175indole-containing compound metabolic process (GO:0042430)2.32065639
176tRNA processing (GO:0008033)2.31768288
177maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.31281870
178centriole replication (GO:0007099)2.30614555
179rRNA modification (GO:0000154)2.30213946
180branched-chain amino acid metabolic process (GO:0009081)2.30137969
181GPI anchor metabolic process (GO:0006505)2.29082256
182reflex (GO:0060004)2.26967761
183mannosylation (GO:0097502)2.26849764
184synapsis (GO:0007129)2.26624051
185tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.26316394

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.99067402
2GBX2_23144817_ChIP-Seq_PC3_Human4.27944072
3TAF15_26573619_Chip-Seq_HEK293_Human3.27673776
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.85825415
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48539370
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.45399980
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.37677390
8* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.26705049
9EWS_26573619_Chip-Seq_HEK293_Human2.25605351
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25139090
11REST_21632747_ChIP-Seq_MESCs_Mouse2.23785592
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.18760936
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13128980
14VDR_22108803_ChIP-Seq_LS180_Human2.11626157
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09185069
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.05566093
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.03575472
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.00343938
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.96205018
20P300_19829295_ChIP-Seq_ESCs_Human1.88055854
21REST_18959480_ChIP-ChIP_MESCs_Mouse1.85522023
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85388720
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.84115535
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84095294
25ZNF274_21170338_ChIP-Seq_K562_Hela1.83386072
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82465208
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.81797046
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.77865453
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.75396754
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72821773
31FUS_26573619_Chip-Seq_HEK293_Human1.72769213
32SMAD4_21799915_ChIP-Seq_A2780_Human1.71419127
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69488950
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69358091
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67052462
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66589030
37ELK1_19687146_ChIP-ChIP_HELA_Human1.65064078
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.64455182
39SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.62638541
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60417166
41ER_23166858_ChIP-Seq_MCF-7_Human1.60362798
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59719313
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59346027
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57931436
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57022257
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.56126046
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.54914867
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.54914867
49* VDR_23849224_ChIP-Seq_CD4+_Human1.54883894
50TP53_22573176_ChIP-Seq_HFKS_Human1.53463918
51MYC_18940864_ChIP-ChIP_HL60_Human1.53402249
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52230594
53FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.50913209
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49926932
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49706534
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.48990551
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47368004
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.46887866
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46373317
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.44577173
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44175647
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44072816
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43233690
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.42442053
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.42410034
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40566350
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.38849259
68CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.37751862
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37669117
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.36950364
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35810680
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.34734488
73* ETS1_20019798_ChIP-Seq_JURKAT_Human1.34572063
74SOX2_19829295_ChIP-Seq_ESCs_Human1.34511437
75NANOG_19829295_ChIP-Seq_ESCs_Human1.34511437
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34108725
77SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34022221
78AR_25329375_ChIP-Seq_VCAP_Human1.32258982
79* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29207145
80* SRF_21415370_ChIP-Seq_HL-1_Mouse1.29182447
81BCAT_22108803_ChIP-Seq_LS180_Human1.27494961
82AR_21572438_ChIP-Seq_LNCaP_Human1.24223217
83P53_22387025_ChIP-Seq_ESCs_Mouse1.24111444
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23048307
85JUN_21703547_ChIP-Seq_K562_Human1.22957444
86IRF1_19129219_ChIP-ChIP_H3396_Human1.22707235
87HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22610465
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21690835
89SOX9_26525672_Chip-Seq_HEART_Mouse1.20372238
90RNF2_27304074_Chip-Seq_ESCs_Mouse1.19995468
91E2F1_18555785_Chip-Seq_ESCs_Mouse1.19798908
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19393047
93TCF4_23295773_ChIP-Seq_U87_Human1.18420302
94CMYC_18555785_Chip-Seq_ESCs_Mouse1.17597349
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17595838
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.17595838
97TAL1_26923725_Chip-Seq_HPCs_Mouse1.17465436
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.17066285
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16326693
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15700410
101ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15343670
102RNF2_27304074_Chip-Seq_NSC_Mouse1.15227819
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14411529
104* FLI1_21867929_ChIP-Seq_TH2_Mouse1.14036807
105SOX2_18555785_Chip-Seq_ESCs_Mouse1.13901149
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13085411
107SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12619701
108STAT3_18555785_Chip-Seq_ESCs_Mouse1.12614461
109TCF4_22108803_ChIP-Seq_LS180_Human1.11613885
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11409711
111SOX2_21211035_ChIP-Seq_LN229_Gbm1.10604294
112SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10066907
113JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10035260
114PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09260069
115P300_18555785_Chip-Seq_ESCs_Mouse1.08732504
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08516172
117FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08293443
118BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07598720
119* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07306784
120FOXP3_21729870_ChIP-Seq_TREG_Human1.06647004
121STAT3_23295773_ChIP-Seq_U87_Human1.06555891
122MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06476929
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06285709
124NCOR_22424771_ChIP-Seq_293T_Human1.06272799
125EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06185308
126IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05891251
127TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05722700
128SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04792309
129NFE2_27457419_Chip-Seq_LIVER_Mouse1.04751743
130THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03750643
131PIAS1_25552417_ChIP-Seq_VCAP_Human1.03631408
132CBP_20019798_ChIP-Seq_JUKART_Human1.03535214
133IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03535214
134TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03239478
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03239478
136E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02481301
137NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02052950
138PRDM14_20953172_ChIP-Seq_ESCs_Human1.01887253
139RUNX2_22187159_ChIP-Seq_PCA_Human1.01108860
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00662522
141RUNX1_27457419_Chip-Seq_LIVER_Mouse1.00497750
142IGF1R_20145208_ChIP-Seq_DFB_Human1.00369226
143MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98913299
144DROSHA_22980978_ChIP-Seq_HELA_Human0.98244078
145RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97990865

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.32301822
2MP0004859_abnormal_synaptic_plasticity3.96340761
3MP0002837_dystrophic_cardiac_calcinosis3.34871411
4MP0003635_abnormal_synaptic_transmissio3.12648194
5MP0001529_abnormal_vocalization3.04465757
6MP0001968_abnormal_touch/_nociception2.84098501
7MP0009745_abnormal_behavioral_response2.76376207
8MP0003646_muscle_fatigue2.67038791
9MP0002064_seizures2.61770659
10MP0002063_abnormal_learning/memory/cond2.59680457
11MP0002736_abnormal_nociception_after2.53031709
12MP0002272_abnormal_nervous_system2.47163021
13MP0004270_analgesia2.43079191
14MP0002572_abnormal_emotion/affect_behav2.43042266
15MP0009046_muscle_twitch2.42230206
16MP0000569_abnormal_digit_pigmentation2.28605156
17MP0003195_calcinosis2.21927279
18MP0002735_abnormal_chemical_nociception2.21307735
19MP0004215_abnormal_myocardial_fiber2.19078525
20MP0005646_abnormal_pituitary_gland2.18750915
21MP0000751_myopathy2.15228443
22MP0000749_muscle_degeneration2.05125178
23MP0001905_abnormal_dopamine_level2.04484832
24MP0004142_abnormal_muscle_tone2.02722589
25MP0002734_abnormal_mechanical_nocicepti2.02095407
26MP0005410_abnormal_fertilization2.02082089
27MP0004036_abnormal_muscle_relaxation1.98165917
28MP0001486_abnormal_startle_reflex1.97591133
29MP0002067_abnormal_sensory_capabilities1.95802419
30MP0006276_abnormal_autonomic_nervous1.95595631
31MP0001440_abnormal_grooming_behavior1.94277431
32MP0003787_abnormal_imprinting1.88677032
33MP0006036_abnormal_mitochondrial_physio1.88312603
34MP0000372_irregular_coat_pigmentation1.88203407
35MP0001984_abnormal_olfaction1.87462499
36MP0004145_abnormal_muscle_electrophysio1.81221125
37MP0005386_behavior/neurological_phenoty1.78276759
38MP0004924_abnormal_behavior1.78276759
39MP0002638_abnormal_pupillary_reflex1.73942671
40MP0006035_abnormal_mitochondrial_morpho1.72439150
41MP0004084_abnormal_cardiac_muscle1.68230507
42MP0005253_abnormal_eye_physiology1.67965353
43MP0001501_abnormal_sleep_pattern1.66926319
44MP0008058_abnormal_DNA_repair1.62345067
45MP0001970_abnormal_pain_threshold1.62048303
46MP0004484_altered_response_of1.60057955
47MP0002102_abnormal_ear_morphology1.58778930
48MP0009780_abnormal_chondrocyte_physiolo1.57758965
49MP0002733_abnormal_thermal_nociception1.53845393
50MP0001188_hyperpigmentation1.52120028
51MP0000427_abnormal_hair_cycle1.49861167
52MP0002557_abnormal_social/conspecific_i1.48262976
53MP0008057_abnormal_DNA_replication1.43125056
54MP0004885_abnormal_endolymph1.36465477
55MP0000778_abnormal_nervous_system1.34563558
56MP0008775_abnormal_heart_ventricle1.33607106
57MP0003879_abnormal_hair_cell1.33602774
58MP0002822_catalepsy1.33421023
59MP0002234_abnormal_pharynx_morphology1.33295726
60MP0008569_lethality_at_weaning1.32282993
61MP0002938_white_spotting1.32100683
62MP0008877_abnormal_DNA_methylation1.29571741
63MP0005174_abnormal_tail_pigmentation1.28531487
64MP0002184_abnormal_innervation1.27366281
65MP0002876_abnormal_thyroid_physiology1.25167630
66MP0005620_abnormal_muscle_contractility1.24053184
67MP0008995_early_reproductive_senescence1.21558949
68MP0004085_abnormal_heartbeat1.21257797
69MP0002066_abnormal_motor_capabilities/c1.20697972
70MP0003137_abnormal_impulse_conducting1.20572863
71MP0003718_maternal_effect1.18644687
72MP0000631_abnormal_neuroendocrine_gland1.18347926
73MP0005330_cardiomyopathy1.17674622
74MP0002160_abnormal_reproductive_system1.16741861
75MP0002972_abnormal_cardiac_muscle1.14912143
76MP0003122_maternal_imprinting1.14617362
77MP0003136_yellow_coat_color1.12210364
78MP0004043_abnormal_pH_regulation1.12119082
79MP0004147_increased_porphyrin_level1.09928794
80MP0005645_abnormal_hypothalamus_physiol1.08084182
81MP0003329_amyloid_beta_deposits1.07737775
82MP0005389_reproductive_system_phenotype1.06307387
83MP0002095_abnormal_skin_pigmentation1.05814456
84MP0004811_abnormal_neuron_physiology1.05183363
85MP0005266_abnormal_metabolism1.04942537
86MP0005332_abnormal_amino_acid1.04764714
87MP0005551_abnormal_eye_electrophysiolog1.04491551
88MP0010094_abnormal_chromosome_stability1.04400592
89MP0005379_endocrine/exocrine_gland_phen1.02232860
90MP0005075_abnormal_melanosome_morpholog1.02223377
91MP0002106_abnormal_muscle_physiology1.02171578
92MP0002882_abnormal_neuron_morphology1.01856441
93MP0008875_abnormal_xenobiotic_pharmacok1.00165695
94MP0003786_premature_aging1.00067457
95MP0002693_abnormal_pancreas_physiology0.99245905
96MP0002229_neurodegeneration0.99013716
97MP0001485_abnormal_pinna_reflex0.98456347
98MP0003283_abnormal_digestive_organ0.97024495
99MP0003950_abnormal_plasma_membrane0.96465993
100MP0005423_abnormal_somatic_nervous0.95766300
101MP0008872_abnormal_physiological_respon0.95210339
102MP0002163_abnormal_gland_morphology0.92425189
103MP0001661_extended_life_span0.92403550
104MP0004130_abnormal_muscle_cell0.91116733
105MP0005535_abnormal_body_temperature0.90065947
106MP0001919_abnormal_reproductive_system0.89956540
107MP0000955_abnormal_spinal_cord0.89739888
108MP0003633_abnormal_nervous_system0.88970963
109MP0005369_muscle_phenotype0.87149028
110MP0009697_abnormal_copulation0.86456045
111MP0001764_abnormal_homeostasis0.86443858
112MP0003698_abnormal_male_reproductive0.85965037
113MP0005187_abnormal_penis_morphology0.85787324
114MP0006292_abnormal_olfactory_placode0.84744988
115MP0001963_abnormal_hearing_physiology0.84743141
116MP0002928_abnormal_bile_duct0.83321410
117MP0000920_abnormal_myelination0.82783024
118MP0003011_delayed_dark_adaptation0.82502087
119MP0001929_abnormal_gametogenesis0.81777591
120MP0002269_muscular_atrophy0.81281613
121MP0004133_heterotaxia0.81103550
122MP0000759_abnormal_skeletal_muscle0.80818998
123MP0004087_abnormal_muscle_fiber0.80153650
124MP0005636_abnormal_mineral_homeostasis0.79934929
125MP0001502_abnormal_circadian_rhythm0.79372876
126MP0004233_abnormal_muscle_weight0.79294810
127MP0003631_nervous_system_phenotype0.79200780
128MP0004742_abnormal_vestibular_system0.78865949
129MP0002909_abnormal_adrenal_gland0.78737809
130MP0005409_darkened_coat_color0.77491348
131MP0003806_abnormal_nucleotide_metabolis0.77231050
132MP0001986_abnormal_taste_sensitivity0.76936129
133MP0000747_muscle_weakness0.76415009
134MP0003656_abnormal_erythrocyte_physiolo0.76410741
135MP0000013_abnormal_adipose_tissue0.74149754
136MP0001664_abnormal_digestion0.73943073
137MP0006072_abnormal_retinal_apoptosis0.70473053
138MP0002152_abnormal_brain_morphology0.69208494
139MP0003183_abnormal_peptide_metabolism0.68728766
140MP0005171_absent_coat_pigmentation0.67094460
141MP0002752_abnormal_somatic_nervous0.66926018

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.96112287
2Abnormal mitochondria in muscle tissue (HP:0008316)5.72535814
3Focal motor seizures (HP:0011153)5.50150076
4Progressive macrocephaly (HP:0004481)5.04054643
5Acute encephalopathy (HP:0006846)4.96072058
6Increased serum pyruvate (HP:0003542)4.75099269
7Abnormality of glycolysis (HP:0004366)4.75099269
8Mitochondrial inheritance (HP:0001427)4.67538571
9Hepatocellular necrosis (HP:0001404)4.66774641
10Hyperventilation (HP:0002883)4.31834989
11Increased CSF lactate (HP:0002490)4.17866593
12Hepatic necrosis (HP:0002605)4.13291121
13Epileptic encephalopathy (HP:0200134)4.11915139
14Pancreatic cysts (HP:0001737)3.95440208
15Pancreatic fibrosis (HP:0100732)3.56141947
16Abnormality of midbrain morphology (HP:0002418)3.44354278
17Molar tooth sign on MRI (HP:0002419)3.44354278
18Cerebral edema (HP:0002181)3.41674095
19Pheochromocytoma (HP:0002666)3.39402923
20Abnormality of the renal cortex (HP:0011035)3.32844684
21Atonic seizures (HP:0010819)3.31010527
22Neuroendocrine neoplasm (HP:0100634)3.28949258
23Optic disc pallor (HP:0000543)3.25565361
24Nephronophthisis (HP:0000090)3.21244574
25* Lactic acidosis (HP:0003128)3.19443012
26Congenital stationary night blindness (HP:0007642)3.18850812
27Leukodystrophy (HP:0002415)3.17480583
28Renal cortical cysts (HP:0000803)3.12459772
29Exercise intolerance (HP:0003546)3.08220276
30True hermaphroditism (HP:0010459)3.03715775
31Exercise-induced myalgia (HP:0003738)3.03274353
32* Respiratory failure (HP:0002878)3.01092034
33Focal seizures (HP:0007359)2.99211114
34Muscle hypertrophy of the lower extremities (HP:0008968)2.97220323
35Ketoacidosis (HP:0001993)2.96194796
36Visual hallucinations (HP:0002367)2.95363561
37Febrile seizures (HP:0002373)2.93242674
38Myokymia (HP:0002411)2.93138914
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.91869402
40Abnormality of alanine metabolism (HP:0010916)2.91869402
41Hyperalaninemia (HP:0003348)2.91869402
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.90832024
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.90832024
44Absence seizures (HP:0002121)2.81639868
45Medial flaring of the eyebrow (HP:0010747)2.75738248
46Calf muscle hypertrophy (HP:0008981)2.73983394
47Gait imbalance (HP:0002141)2.73322076
48Sudden death (HP:0001699)2.67720491
49Abnormality of the renal medulla (HP:0100957)2.67624961
50Broad-based gait (HP:0002136)2.65993720
51* Increased serum lactate (HP:0002151)2.63447124
52Dialeptic seizures (HP:0011146)2.60548545
53Methylmalonic acidemia (HP:0002912)2.58005679
54Type II lissencephaly (HP:0007260)2.56269290
55Congenital primary aphakia (HP:0007707)2.52222579
56Increased hepatocellular lipid droplets (HP:0006565)2.51791608
57Methylmalonic aciduria (HP:0012120)2.51081407
58Increased intramyocellular lipid droplets (HP:0012240)2.49198700
59Attenuation of retinal blood vessels (HP:0007843)2.48959418
60Large for gestational age (HP:0001520)2.48879875
61Dynein arm defect of respiratory motile cilia (HP:0012255)2.46733007
62Absent/shortened dynein arms (HP:0200106)2.46733007
63Nephrogenic diabetes insipidus (HP:0009806)2.44436862
64Generalized tonic-clonic seizures (HP:0002069)2.40103834
65Ketosis (HP:0001946)2.33994611
66Abnormal hair whorl (HP:0010721)2.32620920
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.30780736
68Cholecystitis (HP:0001082)2.30468233
69Abnormal gallbladder physiology (HP:0012438)2.30468233
70Anxiety (HP:0000739)2.27060756
71Progressive inability to walk (HP:0002505)2.27040321
72X-linked dominant inheritance (HP:0001423)2.26328188
73Lipid accumulation in hepatocytes (HP:0006561)2.24721169
74Furrowed tongue (HP:0000221)2.21631981
75Drooling (HP:0002307)2.21576861
76Excessive salivation (HP:0003781)2.21576861
77Chronic hepatic failure (HP:0100626)2.20313558
78CNS demyelination (HP:0007305)2.17253935
79Tubular atrophy (HP:0000092)2.16601728
80Abnormal rod and cone electroretinograms (HP:0008323)2.14707390
81Myoglobinuria (HP:0002913)2.14203670
82Increased muscle lipid content (HP:0009058)2.13144003
83Poor suck (HP:0002033)2.13078544
84Polydipsia (HP:0001959)2.12973139
85Abnormal drinking behavior (HP:0030082)2.12973139
86Emotional lability (HP:0000712)2.12108855
87Abnormality of the calf musculature (HP:0001430)2.10357352
88Muscle fiber inclusion bodies (HP:0100299)2.09638983
89Cystic liver disease (HP:0006706)2.09282271
90Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.07890316
91Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.07864049
92Degeneration of the lateral corticospinal tracts (HP:0002314)2.07864049
93Termporal pattern (HP:0011008)2.07127966
94Insidious onset (HP:0003587)2.07127966
95Hyperinsulinemic hypoglycemia (HP:0000825)2.05901449
96Exercise-induced muscle cramps (HP:0003710)2.05216797
97Abolished electroretinogram (ERG) (HP:0000550)2.04636323
98Left ventricular hypertrophy (HP:0001712)2.04348203
993-Methylglutaconic aciduria (HP:0003535)2.01987294
100Sensory axonal neuropathy (HP:0003390)2.00298855
101Hypothermia (HP:0002045)1.98120716
102Ragged-red muscle fibers (HP:0003200)1.97960144
103Hypoglycemic coma (HP:0001325)1.97208206
104Nemaline bodies (HP:0003798)1.96995858
105Poor eye contact (HP:0000817)1.96443041
106Impaired vibration sensation in the lower limbs (HP:0002166)1.95688616
107Bile duct proliferation (HP:0001408)1.94924863
108Abnormal biliary tract physiology (HP:0012439)1.94924863
109Intestinal atresia (HP:0011100)1.94641315
110Poor coordination (HP:0002370)1.94069725
111Atrial fibrillation (HP:0005110)1.94028672
112Renal Fanconi syndrome (HP:0001994)1.92594652
113Sclerocornea (HP:0000647)1.92558419
114Progressive cerebellar ataxia (HP:0002073)1.91735936
115Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.91442262
116Gaze-evoked nystagmus (HP:0000640)1.90528467
117Pendular nystagmus (HP:0012043)1.88798769
118Polyphagia (HP:0002591)1.87049783
119Epileptiform EEG discharges (HP:0011182)1.86307257
120Genital tract atresia (HP:0001827)1.83588132
121Primary atrial arrhythmia (HP:0001692)1.82392828
122Syncope (HP:0001279)1.81117523
123Abnormality of the corticospinal tract (HP:0002492)1.80927961
124Aplasia/Hypoplasia of the tibia (HP:0005772)1.79997957
125Protruding tongue (HP:0010808)1.79759221
126Inability to walk (HP:0002540)1.78493338
127Supraventricular tachycardia (HP:0004755)1.78326194
128Aplasia/Hypoplasia of the tongue (HP:0010295)1.78260940
129Hyperglycinuria (HP:0003108)1.77544803
130Vaginal atresia (HP:0000148)1.77352921
131Delusions (HP:0000746)1.77123322
132Congenital, generalized hypertrichosis (HP:0004540)1.76875804
133Abnormal eating behavior (HP:0100738)1.76805334
134Abnormality of the pons (HP:0007361)1.76475377
135* Lethargy (HP:0001254)1.76094154
136Lissencephaly (HP:0001339)1.75439769
137Abnormality of vitamin B metabolism (HP:0004340)1.74600353
138Delayed gross motor development (HP:0002194)1.74411778
139Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73844158
140Hemiparesis (HP:0001269)1.73778701
141Poor speech (HP:0002465)1.73360768
142Rhabdomyolysis (HP:0003201)1.72811623
143Respiratory difficulties (HP:0002880)1.72723023
144Unsteady gait (HP:0002317)1.72416445
145Aplasia/Hypoplasia of the uvula (HP:0010293)1.72332202
146Severe muscular hypotonia (HP:0006829)1.71365971
147Congenital hepatic fibrosis (HP:0002612)1.70673030
148Neoplasm of the adrenal cortex (HP:0100641)1.70291422
149Tachypnea (HP:0002789)1.68953473
150Hypoplasia of the pons (HP:0012110)1.68196531
151Neoplasm of the adrenal gland (HP:0100631)1.66379767
152Male pseudohermaphroditism (HP:0000037)1.65178152
153Decreased electroretinogram (ERG) amplitude (HP:0000654)1.63907297
154Fair hair (HP:0002286)1.63076882
155Constricted visual fields (HP:0001133)1.63066234
156Colon cancer (HP:0003003)1.62947656
157Hyperglycemia (HP:0003074)1.60912228
158Hypsarrhythmia (HP:0002521)1.60694878

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.42655798
2CASK5.71985609
3MAP3K123.97472802
4PDK33.25467960
5PDK43.25467960
6NME13.21641601
7BMPR1B2.98241377
8EPHA42.70422860
9MAP3K42.68826355
10MAP2K72.58693594
11NTRK32.54378049
12CDK192.41083746
13MAP4K22.35279426
14ZAK2.25164711
15ACVR1B2.02780812
16CCNB11.96917955
17NUAK11.94198094
18PDK21.89096924
19PLK21.83913823
20TAOK31.83639731
21GRK11.83342789
22MYLK1.80508260
23OBSCN1.71949155
24MARK11.66671214
25DAPK21.60946509
26OXSR11.57463935
27MAP2K41.55847832
28MINK11.50246183
29TRIM281.46216771
30DAPK11.45561145
31INSRR1.38155800
32PRPF4B1.38064071
33STK161.35804277
34EIF2AK31.28651325
35PHKG11.28556060
36PHKG21.28556060
37GRK51.27654972
38TLK11.23343318
39MAPK131.22170264
40ADRBK21.16497856
41BRSK21.12530656
42EIF2AK11.12523643
43PLK41.12394755
44STK241.12267503
45CAMK2A1.10652234
46ERBB31.10614740
47PRKCG1.07088025
48FGFR21.06891109
49RIPK41.06600564
50SIK31.04694672
51STK391.01143230
52SGK2230.99231680
53SGK4940.99231680
54AKT30.98431957
55PNCK0.95390382
56PLK30.93975372
57PTK2B0.93674993
58BMPR20.93657614
59CAMK2B0.92236442
60SGK20.92060526
61PRKD30.91418379
62CAMK2D0.91249963
63MAPKAPK50.91236498
64CAMKK20.90669419
65CSNK1G10.90641125
66TSSK60.89404544
67CSNK1G30.89153646
68TEC0.88811527
69NTRK20.87734759
70WNK30.87685644
71GRK70.84546585
72LMTK20.84426613
73MAPKAPK30.82781174
74NEK10.82742368
75ILK0.82732502
76MUSK0.81595045
77TXK0.80310711
78BRAF0.79490800
79ARAF0.78987114
80CDC70.78024917
81MKNK10.77034628
82CDK50.76814403
83VRK20.75846094
84CAMK10.75745400
85WNK40.74591139
86CSNK1A1L0.73619694
87WEE10.73586302
88PINK10.71785686
89BCR0.70793018
90PIK3CG0.70066449
91PRKCE0.69997431
92PAK60.69836924
93TGFBR10.69657079
94SRPK10.69606271
95MAP2K60.68081601
96MAPK120.66834756
97IRAK10.65527228
98MAP3K70.64617680
99PIK3CA0.64428378
100STK38L0.63493480
101TAF10.61416552
102CDK180.61380250
103PAK30.59347295
104DAPK30.58156920
105MAPK70.57815216
106GRK60.57641665
107CAMK2G0.57227229
108PRKAA20.57155994
109PDK10.56888062
110FES0.56481955
111TRPM70.56233778
112MST40.55823729
113UHMK10.55782315
114CDK140.54254596
115CDK150.52762017
116TNIK0.52476029
117PRKACA0.51441389
118ATR0.49633867
119PKN10.48665850
120PLK10.48441601
121PASK0.47159932
122ADRBK10.46262702
123STK30.45951025
124CSNK1G20.45875261
125DYRK20.45674125
126RPS6KA50.44457529
127CDK11A0.44245394
128TESK10.43923591
129EIF2AK20.43180905
130PRKAA10.43024749
131BCKDK0.42707994
132ROCK20.42574388
133PDPK10.42364110
134BUB10.41585040
135CAMKK10.41525473
136CDK30.40972190
137ATM0.40334318
138ITK0.40178893
139VRK10.38885889
140EPHA30.37961707
141MAP3K90.37470736
142DYRK1A0.37413704
143CHEK20.37339799
144SGK10.37154988
145CSNK1D0.36859731
146STK110.36837702
147PRKG10.35899167
148KSR10.35095153
149TIE10.35055683
150MKNK20.31936946
151PRKACB0.31671910
152FGR0.31190132
153MARK20.28991930

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.78237331
2Parkinsons disease_Homo sapiens_hsa050124.12491029
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.72291464
4Alzheimers disease_Homo sapiens_hsa050103.21629084
5Nicotine addiction_Homo sapiens_hsa050333.03136671
6Cardiac muscle contraction_Homo sapiens_hsa042602.94846418
7Huntingtons disease_Homo sapiens_hsa050162.89137257
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.82688558
9Synaptic vesicle cycle_Homo sapiens_hsa047212.56197443
10Collecting duct acid secretion_Homo sapiens_hsa049662.45563350
11Homologous recombination_Homo sapiens_hsa034402.27390146
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.24065266
13Pyruvate metabolism_Homo sapiens_hsa006202.20024614
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.18609135
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.07652782
16Nitrogen metabolism_Homo sapiens_hsa009102.01279467
17Olfactory transduction_Homo sapiens_hsa047401.95547114
18Morphine addiction_Homo sapiens_hsa050321.94788041
19Circadian entrainment_Homo sapiens_hsa047131.93840775
20Amphetamine addiction_Homo sapiens_hsa050311.89469083
21GABAergic synapse_Homo sapiens_hsa047271.86153253
22Fanconi anemia pathway_Homo sapiens_hsa034601.82191914
23Linoleic acid metabolism_Homo sapiens_hsa005911.72961483
24Propanoate metabolism_Homo sapiens_hsa006401.71141466
25Selenocompound metabolism_Homo sapiens_hsa004501.70197473
26One carbon pool by folate_Homo sapiens_hsa006701.68315686
27Fatty acid elongation_Homo sapiens_hsa000621.64502356
28Glutamatergic synapse_Homo sapiens_hsa047241.62845998
29Long-term potentiation_Homo sapiens_hsa047201.61801279
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61153679
31Tryptophan metabolism_Homo sapiens_hsa003801.55961840
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53876669
33Dopaminergic synapse_Homo sapiens_hsa047281.53685419
34RNA degradation_Homo sapiens_hsa030181.50392554
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49542743
36Taste transduction_Homo sapiens_hsa047421.46119729
37Proteasome_Homo sapiens_hsa030501.45007859
38Vibrio cholerae infection_Homo sapiens_hsa051101.37007620
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.34468613
40Serotonergic synapse_Homo sapiens_hsa047261.31901490
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.30463246
42Carbon metabolism_Homo sapiens_hsa012001.29106566
43Calcium signaling pathway_Homo sapiens_hsa040201.27675732
44Salivary secretion_Homo sapiens_hsa049701.25133891
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23759800
46Insulin secretion_Homo sapiens_hsa049111.18425036
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17168690
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15448232
49Renin secretion_Homo sapiens_hsa049241.13606236
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11416075
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11301972
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10613962
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10279116
54Non-homologous end-joining_Homo sapiens_hsa034501.06717051
55Cholinergic synapse_Homo sapiens_hsa047251.05009680
56Phototransduction_Homo sapiens_hsa047441.03487244
57Nucleotide excision repair_Homo sapiens_hsa034201.02643396
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01969550
59Oxytocin signaling pathway_Homo sapiens_hsa049211.00227478
60Caffeine metabolism_Homo sapiens_hsa002320.95835785
61ABC transporters_Homo sapiens_hsa020100.94839623
62beta-Alanine metabolism_Homo sapiens_hsa004100.92938967
63Butanoate metabolism_Homo sapiens_hsa006500.89272660
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88732474
65Mismatch repair_Homo sapiens_hsa034300.87469943
66Gastric acid secretion_Homo sapiens_hsa049710.83994274
67Long-term depression_Homo sapiens_hsa047300.83433388
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82294929
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81796001
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81339754
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79793428
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78885447
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78794027
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78536417
75Glucagon signaling pathway_Homo sapiens_hsa049220.77957943
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77111832
77Dilated cardiomyopathy_Homo sapiens_hsa054140.76897900
78Cocaine addiction_Homo sapiens_hsa050300.75816291
79Pyrimidine metabolism_Homo sapiens_hsa002400.75096685
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73445246
81Vitamin B6 metabolism_Homo sapiens_hsa007500.72971877
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71590930
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70018011
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.69977643
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.66953195
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65905300
87RNA transport_Homo sapiens_hsa030130.65738198
88Fatty acid metabolism_Homo sapiens_hsa012120.63998621
89Chemical carcinogenesis_Homo sapiens_hsa052040.63451763
90Retinol metabolism_Homo sapiens_hsa008300.62374929
91RNA polymerase_Homo sapiens_hsa030200.60611565
92Sulfur metabolism_Homo sapiens_hsa009200.60535832
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.58755303
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.58265141
95Steroid biosynthesis_Homo sapiens_hsa001000.57658551
96Metabolic pathways_Homo sapiens_hsa011000.57589199
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56230169
98Ovarian steroidogenesis_Homo sapiens_hsa049130.55860937
99cAMP signaling pathway_Homo sapiens_hsa040240.55540146
100Protein export_Homo sapiens_hsa030600.54949368
101Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53570757
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53415593
103Purine metabolism_Homo sapiens_hsa002300.51715770
104Biosynthesis of amino acids_Homo sapiens_hsa012300.50674229
105Gap junction_Homo sapiens_hsa045400.50507847
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50242931
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50134688
108Ribosome_Homo sapiens_hsa030100.49485345
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49228215
110Arachidonic acid metabolism_Homo sapiens_hsa005900.48304725
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47872068
112Oocyte meiosis_Homo sapiens_hsa041140.47378133
113Regulation of autophagy_Homo sapiens_hsa041400.47329757
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46931043
115Folate biosynthesis_Homo sapiens_hsa007900.45758127
116Glycerolipid metabolism_Homo sapiens_hsa005610.43743307
117Rheumatoid arthritis_Homo sapiens_hsa053230.42652909
118Circadian rhythm_Homo sapiens_hsa047100.42271317
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42186113
120Fatty acid degradation_Homo sapiens_hsa000710.41727912
121Type I diabetes mellitus_Homo sapiens_hsa049400.41258968
122DNA replication_Homo sapiens_hsa030300.40146606
123Histidine metabolism_Homo sapiens_hsa003400.39794751
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39049827
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38850812
126Fructose and mannose metabolism_Homo sapiens_hsa000510.38795987
127GnRH signaling pathway_Homo sapiens_hsa049120.37941474
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34105883
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33700675
130ErbB signaling pathway_Homo sapiens_hsa040120.33353047
131Axon guidance_Homo sapiens_hsa043600.32716241
132Fatty acid biosynthesis_Homo sapiens_hsa000610.31891108
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28065165
134Estrogen signaling pathway_Homo sapiens_hsa049150.24084787
135Tyrosine metabolism_Homo sapiens_hsa003500.21327493
136Basal transcription factors_Homo sapiens_hsa030220.20583764
137Phenylalanine metabolism_Homo sapiens_hsa003600.19901625
138MAPK signaling pathway_Homo sapiens_hsa040100.19863445
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.17990927
140Pancreatic secretion_Homo sapiens_hsa049720.15677540
141Ras signaling pathway_Homo sapiens_hsa040140.15676918
142Peroxisome_Homo sapiens_hsa041460.15339475
143Melanogenesis_Homo sapiens_hsa049160.15018077
144Ether lipid metabolism_Homo sapiens_hsa005650.13092083
145Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.12907192
146Arginine and proline metabolism_Homo sapiens_hsa003300.12600209

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