

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | neuron cell-cell adhesion (GO:0007158) | 4.95879444 |
| 2 | vocalization behavior (GO:0071625) | 4.86920686 |
| 3 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 4.52972784 |
| 4 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.47384558 |
| 5 | protein localization to synapse (GO:0035418) | 4.27234784 |
| 6 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.23028264 |
| 7 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.22520628 |
| 8 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.02750365 |
| 9 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.88588640 |
| 10 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.88051990 |
| 11 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.86515656 |
| 12 | regulation of cilium movement (GO:0003352) | 3.79796370 |
| 13 | protein localization to cilium (GO:0061512) | 3.77108099 |
| 14 | synaptic vesicle exocytosis (GO:0016079) | 3.77091037 |
| 15 | synaptic transmission, glutamatergic (GO:0035249) | 3.77086751 |
| 16 | glutamate receptor signaling pathway (GO:0007215) | 3.75438279 |
| 17 | neuron-neuron synaptic transmission (GO:0007270) | 3.72304857 |
| 18 | startle response (GO:0001964) | 3.67918132 |
| 19 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.67013808 |
| 20 | cyclic nucleotide catabolic process (GO:0009214) | 3.56706235 |
| 21 | neuronal action potential propagation (GO:0019227) | 3.53570535 |
| 22 | detection of calcium ion (GO:0005513) | 3.49683797 |
| 23 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.45420577 |
| 24 | transmission of nerve impulse (GO:0019226) | 3.44840925 |
| 25 | proline transport (GO:0015824) | 3.44001356 |
| 26 | cAMP catabolic process (GO:0006198) | 3.42535670 |
| 27 | establishment of mitochondrion localization (GO:0051654) | 3.41250092 |
| 28 | regulation of female receptivity (GO:0045924) | 3.40430112 |
| 29 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.39948722 |
| 30 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.37458000 |
| 31 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.37332240 |
| 32 | striatum development (GO:0021756) | 3.37021829 |
| 33 | long-term memory (GO:0007616) | 3.36935669 |
| 34 | mechanosensory behavior (GO:0007638) | 3.36782803 |
| 35 | regulation of synaptic vesicle exocytosis (GO:2000300) | 3.32526057 |
| 36 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.31507379 |
| 37 | negative regulation of appetite (GO:0032099) | 3.31414134 |
| 38 | negative regulation of response to food (GO:0032096) | 3.31414134 |
| 39 | regulation of respiratory system process (GO:0044065) | 3.29192004 |
| 40 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.28671766 |
| 41 | neurotransmitter secretion (GO:0007269) | 3.28259097 |
| 42 | glutamate secretion (GO:0014047) | 3.24234506 |
| 43 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.22060693 |
| 44 | postsynaptic membrane organization (GO:0001941) | 3.20433726 |
| 45 | membrane depolarization during action potential (GO:0086010) | 3.20369926 |
| 46 | presynaptic membrane assembly (GO:0097105) | 3.20071351 |
| 47 | regulation of microtubule-based movement (GO:0060632) | 3.18831038 |
| 48 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.17719448 |
| 49 | neuron recognition (GO:0008038) | 3.17668331 |
| 50 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.16920763 |
| 51 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.15540594 |
| 52 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.14571063 |
| 53 | regulation of postsynaptic membrane potential (GO:0060078) | 3.14371919 |
| 54 | regulation of protein kinase A signaling (GO:0010738) | 3.14179731 |
| 55 | regulation of synaptic vesicle transport (GO:1902803) | 3.13967620 |
| 56 | positive regulation of membrane potential (GO:0045838) | 3.13888028 |
| 57 | locomotory exploration behavior (GO:0035641) | 3.13639823 |
| 58 | righting reflex (GO:0060013) | 3.09410472 |
| 59 | regulation of synapse structural plasticity (GO:0051823) | 3.07995414 |
| 60 | synaptic vesicle maturation (GO:0016188) | 3.05672506 |
| 61 | response to histamine (GO:0034776) | 3.05272305 |
| 62 | retinal cone cell development (GO:0046549) | 3.04680497 |
| 63 | epithelial cilium movement (GO:0003351) | 3.04437777 |
| 64 | positive regulation of neurotransmitter transport (GO:0051590) | 3.04347000 |
| 65 | neurotransmitter transport (GO:0006836) | 3.03973153 |
| 66 | regulation of respiratory gaseous exchange (GO:0043576) | 3.03114598 |
| 67 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 3.00243569 |
| 68 | membrane hyperpolarization (GO:0060081) | 3.00137499 |
| 69 | catecholamine transport (GO:0051937) | 3.00059289 |
| 70 | auditory behavior (GO:0031223) | 2.99931154 |
| 71 | calcium ion-dependent exocytosis (GO:0017156) | 2.99595717 |
| 72 | membrane depolarization (GO:0051899) | 2.99469107 |
| 73 | negative regulation of dendrite development (GO:2000171) | 2.97350393 |
| 74 | axoneme assembly (GO:0035082) | 2.96461342 |
| 75 | nucleobase catabolic process (GO:0046113) | 2.96082809 |
| 76 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.94952997 |
| 77 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.94303193 |
| 78 | presynaptic membrane organization (GO:0097090) | 2.94286538 |
| 79 | C4-dicarboxylate transport (GO:0015740) | 2.90882654 |
| 80 | gamma-aminobutyric acid transport (GO:0015812) | 2.90280078 |
| 81 | regulation of synapse maturation (GO:0090128) | 2.90195437 |
| 82 | exploration behavior (GO:0035640) | 2.88720302 |
| 83 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.88704153 |
| 84 | regulation of vesicle fusion (GO:0031338) | 2.87989958 |
| 85 | female mating behavior (GO:0060180) | 2.87566042 |
| 86 | synapse assembly (GO:0007416) | 2.87441571 |
| 87 | regulation of neurotransmitter uptake (GO:0051580) | 2.85927337 |
| 88 | response to auditory stimulus (GO:0010996) | 2.85915911 |
| 89 | positive regulation of neurotransmitter secretion (GO:0001956) | 2.85784014 |
| 90 | detection of light stimulus involved in visual perception (GO:0050908) | 2.84843393 |
| 91 | detection of light stimulus involved in sensory perception (GO:0050962) | 2.84843393 |
| 92 | dicarboxylic acid catabolic process (GO:0043649) | 2.84302236 |
| 93 | learning (GO:0007612) | 2.84167223 |
| 94 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 2.83309967 |
| 95 | regulation of synaptic transmission, GABAergic (GO:0032228) | 2.81718732 |
| 96 | neuronal action potential (GO:0019228) | 2.81273772 |
| 97 | regulation of neurotransmitter secretion (GO:0046928) | 2.80608128 |
| 98 | neuromuscular synaptic transmission (GO:0007274) | 2.80357920 |
| 99 | dopamine transport (GO:0015872) | 2.80156440 |
| 100 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 2.79838179 |
| 101 | peroxisome fission (GO:0016559) | 2.79041397 |
| 102 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 2.78541226 |
| 103 | dendritic spine morphogenesis (GO:0060997) | 2.78409400 |
| 104 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.76601246 |
| 105 | synaptic transmission, dopaminergic (GO:0001963) | 2.75770784 |
| 106 | cilium or flagellum-dependent cell motility (GO:0001539) | 2.72928628 |
| 107 | positive regulation of synapse assembly (GO:0051965) | 2.72415529 |
| 108 | cilium movement (GO:0003341) | 2.71305647 |
| 109 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.71129697 |
| 110 | long-term synaptic potentiation (GO:0060291) | 2.70799450 |
| 111 | ubiquinone biosynthetic process (GO:0006744) | 2.69585091 |
| 112 | behavioral response to ethanol (GO:0048149) | 2.69241660 |
| 113 | regulation of neurotransmitter levels (GO:0001505) | 2.68406558 |
| 114 | negative regulation of dendrite morphogenesis (GO:0050774) | 2.68034590 |
| 115 | response to amphetamine (GO:0001975) | 2.67061466 |
| 116 | synaptic vesicle endocytosis (GO:0048488) | 2.66879034 |
| 117 | synaptic transmission (GO:0007268) | 2.66350925 |
| 118 | behavioral response to cocaine (GO:0048148) | 2.64930027 |
| 119 | calcium ion import (GO:0070509) | 2.64746552 |
| 120 | regulation of neurotransmitter transport (GO:0051588) | 2.63744395 |
| 121 | intraspecies interaction between organisms (GO:0051703) | 2.63265242 |
| 122 | social behavior (GO:0035176) | 2.63265242 |
| 123 | glycosphingolipid biosynthetic process (GO:0006688) | 2.62442974 |
| 124 | behavioral defense response (GO:0002209) | 2.61703533 |
| 125 | behavioral fear response (GO:0001662) | 2.61703533 |
| 126 | positive regulation of protein homodimerization activity (GO:0090073) | 2.60972375 |
| 127 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.60888612 |
| 128 | nonmotile primary cilium assembly (GO:0035058) | 2.60691508 |
| 129 | intraciliary transport (GO:0042073) | 2.60147526 |
| 130 | cerebellum development (GO:0021549) | 2.59600651 |
| 131 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.59222271 |
| 132 | neuronal ion channel clustering (GO:0045161) | 2.59059253 |
| 133 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 2.57939674 |
| 134 | mitochondrion transport along microtubule (GO:0047497) | 2.57939674 |
| 135 | cGMP metabolic process (GO:0046068) | 2.57610344 |
| 136 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316 | 2.52865643 |
| 137 | positive regulation of mitochondrial fission (GO:0090141) | 2.51681173 |
| 138 | protein-cofactor linkage (GO:0018065) | 2.51652853 |
| 139 | dendritic spine organization (GO:0097061) | 2.51040593 |
| 140 | brain morphogenesis (GO:0048854) | 2.48345505 |
| 141 | glycine transport (GO:0015816) | 2.44899800 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.34448289 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 4.14493133 |
| 3 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.72936029 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.54250270 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.52699687 |
| 6 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.43728250 |
| 7 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.39533902 |
| 8 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.37833985 |
| 9 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.36113929 |
| 10 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.35162870 |
| 11 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.34624821 |
| 12 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.15068586 |
| 13 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.05889250 |
| 14 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.03453933 |
| 15 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.96400022 |
| 16 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.95750130 |
| 17 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.95164247 |
| 18 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.92789509 |
| 19 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.92789150 |
| 20 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.91681964 |
| 21 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.91629441 |
| 22 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.89211348 |
| 23 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.89118973 |
| 24 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.87918343 |
| 25 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.87620093 |
| 26 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.85547708 |
| 27 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.85547708 |
| 28 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.83843504 |
| 29 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.83341245 |
| 30 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.81491860 |
| 31 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.81136495 |
| 32 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.80911334 |
| 33 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.77491906 |
| 34 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.75492895 |
| 35 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.74357950 |
| 36 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.70483307 |
| 37 | P300_19829295_ChIP-Seq_ESCs_Human | 1.70149257 |
| 38 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.69722294 |
| 39 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.68277553 |
| 40 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.66075293 |
| 41 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.60247268 |
| 42 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.56362857 |
| 43 | FUS_26573619_Chip-Seq_HEK293_Human | 1.55281082 |
| 44 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.52753370 |
| 45 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.52233885 |
| 46 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.48277103 |
| 47 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.46120272 |
| 48 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.44925831 |
| 49 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.43156066 |
| 50 | VDR_22108803_ChIP-Seq_LS180_Human | 1.43128420 |
| 51 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.39610261 |
| 52 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.39427471 |
| 53 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.39234130 |
| 54 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.38529016 |
| 55 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.35497149 |
| 56 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.34523232 |
| 57 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.33812334 |
| 58 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.32395403 |
| 59 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.31639553 |
| 60 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.31092958 |
| 61 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.30824261 |
| 62 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.30273780 |
| 63 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.29300126 |
| 64 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.29059657 |
| 65 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.28772139 |
| 66 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.28341345 |
| 67 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.28249200 |
| 68 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.28249200 |
| 69 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.26991306 |
| 70 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.26387442 |
| 71 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.26375119 |
| 72 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.26353445 |
| 73 | TCF4_23295773_ChIP-Seq_U87_Human | 1.26123143 |
| 74 | AR_25329375_ChIP-Seq_VCAP_Human | 1.25191420 |
| 75 | P300_18555785_Chip-Seq_ESCs_Mouse | 1.23204201 |
| 76 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 1.22732561 |
| 77 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.22539409 |
| 78 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.22267391 |
| 79 | STAT3_23295773_ChIP-Seq_U87_Human | 1.21678124 |
| 80 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.20925670 |
| 81 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 1.19922854 |
| 82 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.19871494 |
| 83 | NMYC_18555785_Chip-Seq_ESCs_Mouse | 1.19081443 |
| 84 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.17783935 |
| 85 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.17579047 |
| 86 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.16772627 |
| 87 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.16772627 |
| 88 | RUNX1_27457419_Chip-Seq_LIVER_Mouse | 1.14927253 |
| 89 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.14757167 |
| 90 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.14593317 |
| 91 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.14436164 |
| 92 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.13793046 |
| 93 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.13771108 |
| 94 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.12206972 |
| 95 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.12053894 |
| 96 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.11963618 |
| 97 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 1.09985512 |
| 98 | EWS_26573619_Chip-Seq_HEK293_Human | 1.08971607 |
| 99 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.08632461 |
| 100 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.08345150 |
| 101 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.08063791 |
| 102 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.07812630 |
| 103 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.07363564 |
| 104 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.05711278 |
| 105 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.05585442 |
| 106 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.05546225 |
| 107 | CTCF_18555785_Chip-Seq_ESCs_Mouse | 1.05429550 |
| 108 | KDM2B_26808549_Chip-Seq_REH_Human | 1.05257705 |
| 109 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.04669133 |
| 110 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.04527128 |
| 111 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.04443417 |
| 112 | KLF4_18555785_Chip-Seq_ESCs_Mouse | 1.04110849 |
| 113 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.02881542 |
| 114 | PU1_27457419_Chip-Seq_LIVER_Mouse | 1.02870183 |
| 115 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.02430537 |
| 116 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.98250605 |
| 117 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.97876413 |
| 118 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.97869206 |
| 119 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.94819090 |
| 120 | NCOR_22424771_ChIP-Seq_293T_Human | 0.93383161 |
| 121 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.91188553 |
| 122 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.90748210 |
| 123 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.89850678 |
| 124 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.89746969 |
| 125 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.89413996 |
| 126 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.88917091 |
| 127 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.87521439 |
| 128 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.87521439 |
| 129 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.86810872 |
| 130 | AR_19668381_ChIP-Seq_PC3_Human | 0.84358568 |
| 131 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.82772135 |
| 132 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.82493394 |
| 133 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.82262068 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 4.35285820 |
| 2 | MP0004859_abnormal_synaptic_plasticity | 3.95984067 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 3.16979875 |
| 4 | MP0005423_abnormal_somatic_nervous | 3.01277347 |
| 5 | MP0009745_abnormal_behavioral_response | 2.96486472 |
| 6 | MP0002822_catalepsy | 2.89090593 |
| 7 | MP0009046_muscle_twitch | 2.87400970 |
| 8 | MP0001968_abnormal_touch/_nociception | 2.85364379 |
| 9 | MP0001188_hyperpigmentation | 2.67014908 |
| 10 | MP0004270_analgesia | 2.64221758 |
| 11 | MP0002063_abnormal_learning/memory/cond | 2.54682225 |
| 12 | MP0001486_abnormal_startle_reflex | 2.49915145 |
| 13 | MP0002064_seizures | 2.48728899 |
| 14 | MP0002572_abnormal_emotion/affect_behav | 2.47408040 |
| 15 | MP0002272_abnormal_nervous_system | 2.42899245 |
| 16 | MP0006276_abnormal_autonomic_nervous | 2.39203135 |
| 17 | MP0001529_abnormal_vocalization | 2.38782006 |
| 18 | MP0002736_abnormal_nociception_after | 2.33276069 |
| 19 | MP0002735_abnormal_chemical_nociception | 2.27802489 |
| 20 | MP0002734_abnormal_mechanical_nocicepti | 2.25662464 |
| 21 | MP0001501_abnormal_sleep_pattern | 1.97265582 |
| 22 | MP0005409_darkened_coat_color | 1.96882211 |
| 23 | MP0005646_abnormal_pituitary_gland | 1.96176774 |
| 24 | MP0001984_abnormal_olfaction | 1.94236851 |
| 25 | MP0005645_abnormal_hypothalamus_physiol | 1.93670334 |
| 26 | MP0002067_abnormal_sensory_capabilities | 1.85378887 |
| 27 | MP0005551_abnormal_eye_electrophysiolog | 1.78554035 |
| 28 | MP0001970_abnormal_pain_threshold | 1.78470375 |
| 29 | MP0006292_abnormal_olfactory_placode | 1.78279291 |
| 30 | MP0000569_abnormal_digit_pigmentation | 1.77954204 |
| 31 | MP0002837_dystrophic_cardiac_calcinosis | 1.76036603 |
| 32 | MP0002653_abnormal_ependyma_morphology | 1.74641255 |
| 33 | MP0001905_abnormal_dopamine_level | 1.73600171 |
| 34 | MP0004924_abnormal_behavior | 1.72321805 |
| 35 | MP0005386_behavior/neurological_phenoty | 1.72321805 |
| 36 | MP0002638_abnormal_pupillary_reflex | 1.71161414 |
| 37 | MP0002733_abnormal_thermal_nociception | 1.68514285 |
| 38 | MP0001440_abnormal_grooming_behavior | 1.68151860 |
| 39 | MP0002557_abnormal_social/conspecific_i | 1.65694558 |
| 40 | MP0003787_abnormal_imprinting | 1.64657129 |
| 41 | MP0002184_abnormal_innervation | 1.60078052 |
| 42 | MP0001986_abnormal_taste_sensitivity | 1.57348855 |
| 43 | MP0004142_abnormal_muscle_tone | 1.57259628 |
| 44 | MP0010386_abnormal_urinary_bladder | 1.49345613 |
| 45 | MP0005410_abnormal_fertilization | 1.45938222 |
| 46 | MP0000778_abnormal_nervous_system | 1.38419718 |
| 47 | MP0002909_abnormal_adrenal_gland | 1.35812200 |
| 48 | MP0008569_lethality_at_weaning | 1.35416841 |
| 49 | MP0004043_abnormal_pH_regulation | 1.33309253 |
| 50 | MP0001502_abnormal_circadian_rhythm | 1.29159224 |
| 51 | MP0003329_amyloid_beta_deposits | 1.28984796 |
| 52 | MP0003646_muscle_fatigue | 1.24679342 |
| 53 | MP0002876_abnormal_thyroid_physiology | 1.23454934 |
| 54 | MP0002882_abnormal_neuron_morphology | 1.21894823 |
| 55 | MP0003122_maternal_imprinting | 1.21236922 |
| 56 | MP0004742_abnormal_vestibular_system | 1.20768321 |
| 57 | MP0006036_abnormal_mitochondrial_physio | 1.20195989 |
| 58 | MP0004811_abnormal_neuron_physiology | 1.15756519 |
| 59 | MP0000015_abnormal_ear_pigmentation | 1.15258328 |
| 60 | MP0002066_abnormal_motor_capabilities/c | 1.13059149 |
| 61 | MP0006072_abnormal_retinal_apoptosis | 1.12987996 |
| 62 | MP0004130_abnormal_muscle_cell | 1.12883849 |
| 63 | MP0004215_abnormal_myocardial_fiber | 1.11792174 |
| 64 | MP0001963_abnormal_hearing_physiology | 1.10469191 |
| 65 | MP0003011_delayed_dark_adaptation | 1.08862882 |
| 66 | MP0002229_neurodegeneration | 1.08553263 |
| 67 | MP0008872_abnormal_physiological_respon | 1.07841971 |
| 68 | MP0005379_endocrine/exocrine_gland_phen | 1.05672544 |
| 69 | MP0000955_abnormal_spinal_cord | 1.04920031 |
| 70 | MP0004145_abnormal_muscle_electrophysio | 1.04602984 |
| 71 | MP0001664_abnormal_digestion | 1.04528161 |
| 72 | MP0005499_abnormal_olfactory_system | 1.04335388 |
| 73 | MP0005394_taste/olfaction_phenotype | 1.04335388 |
| 74 | MP0001485_abnormal_pinna_reflex | 1.04248810 |
| 75 | MP0008995_early_reproductive_senescence | 1.03932878 |
| 76 | MP0009379_abnormal_foot_pigmentation | 1.03659350 |
| 77 | MP0000631_abnormal_neuroendocrine_gland | 1.03292946 |
| 78 | MP0004085_abnormal_heartbeat | 1.02629397 |
| 79 | MP0005253_abnormal_eye_physiology | 1.00130236 |
| 80 | MP0003136_yellow_coat_color | 0.98687164 |
| 81 | MP0003879_abnormal_hair_cell | 0.98633573 |
| 82 | MP0004133_heterotaxia | 0.98591726 |
| 83 | MP0003690_abnormal_glial_cell | 0.96301942 |
| 84 | MP0008877_abnormal_DNA_methylation | 0.96243717 |
| 85 | MP0000751_myopathy | 0.95847583 |
| 86 | MP0002752_abnormal_somatic_nervous | 0.95765434 |
| 87 | MP0005174_abnormal_tail_pigmentation | 0.95271524 |
| 88 | MP0002163_abnormal_gland_morphology | 0.94432089 |
| 89 | MP0002090_abnormal_vision | 0.94037320 |
| 90 | MP0005167_abnormal_blood-brain_barrier | 0.93393786 |
| 91 | MP0000566_synostosis | 0.93005527 |
| 92 | MP0003633_abnormal_nervous_system | 0.92097276 |
| 93 | MP0008875_abnormal_xenobiotic_pharmacok | 0.92005663 |
| 94 | MP0003137_abnormal_impulse_conducting | 0.87554555 |
| 95 | MP0004885_abnormal_endolymph | 0.86830054 |
| 96 | MP0002102_abnormal_ear_morphology | 0.86363811 |
| 97 | MP0002152_abnormal_brain_morphology | 0.83268256 |
| 98 | MP0006035_abnormal_mitochondrial_morpho | 0.82784359 |
| 99 | MP0000026_abnormal_inner_ear | 0.82156375 |
| 100 | MP0005535_abnormal_body_temperature | 0.81292320 |
| 101 | MP0003698_abnormal_male_reproductive | 0.80602689 |
| 102 | MP0000372_irregular_coat_pigmentation | 0.79618763 |
| 103 | MP0009780_abnormal_chondrocyte_physiolo | 0.79080076 |
| 104 | MP0002069_abnormal_eating/drinking_beha | 0.78955107 |
| 105 | MP0004484_altered_response_of | 0.75787574 |
| 106 | MP0003631_nervous_system_phenotype | 0.75703092 |
| 107 | MP0003724_increased_susceptibility_to | 0.73640148 |
| 108 | MP0000604_amyloidosis | 0.72262989 |
| 109 | MP0004147_increased_porphyrin_level | 0.71973316 |
| 110 | MP0002277_abnormal_respiratory_mucosa | 0.71687810 |
| 111 | MP0002095_abnormal_skin_pigmentation | 0.66616556 |
| 112 | MP0008874_decreased_physiological_sensi | 0.62509955 |
| 113 | MP0008789_abnormal_olfactory_epithelium | 0.62061953 |
| 114 | MP0002693_abnormal_pancreas_physiology | 0.61284866 |
| 115 | MP0000678_abnormal_parathyroid_gland | 0.61205248 |
| 116 | MP0000681_abnormal_thyroid_gland | 0.59082158 |
| 117 | MP0005171_absent_coat_pigmentation | 0.59044878 |
| 118 | MP0002751_abnormal_autonomic_nervous | 0.58505436 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 5.66472629 |
| 2 | Febrile seizures (HP:0002373) | 4.69053166 |
| 3 | Epileptic encephalopathy (HP:0200134) | 4.06044204 |
| 4 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 3.84981333 |
| 5 | Absent/shortened dynein arms (HP:0200106) | 3.84981333 |
| 6 | Polyphagia (HP:0002591) | 3.76000550 |
| 7 | Myokymia (HP:0002411) | 3.61403960 |
| 8 | Atonic seizures (HP:0010819) | 3.58902988 |
| 9 | Abnormality of macular pigmentation (HP:0008002) | 3.54182869 |
| 10 | Focal seizures (HP:0007359) | 3.50939341 |
| 11 | Hypothermia (HP:0002045) | 3.43118980 |
| 12 | Severe visual impairment (HP:0001141) | 3.37780844 |
| 13 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 3.36289845 |
| 14 | Medial flaring of the eyebrow (HP:0010747) | 3.35431255 |
| 15 | Visual hallucinations (HP:0002367) | 3.34645774 |
| 16 | Acute necrotizing encephalopathy (HP:0006965) | 3.33805093 |
| 17 | Abnormal ciliary motility (HP:0012262) | 3.33479626 |
| 18 | Broad-based gait (HP:0002136) | 3.26023281 |
| 19 | Gait imbalance (HP:0002141) | 3.25463655 |
| 20 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.22347104 |
| 21 | Abnormal eating behavior (HP:0100738) | 3.14882908 |
| 22 | Progressive cerebellar ataxia (HP:0002073) | 3.06593035 |
| 23 | Abnormal respiratory motile cilium physiology (HP:0012261) | 3.03626974 |
| 24 | Limb dystonia (HP:0002451) | 3.02770809 |
| 25 | Absence seizures (HP:0002121) | 3.00642480 |
| 26 | Hypoplasia of the fovea (HP:0007750) | 2.96694642 |
| 27 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 2.96694642 |
| 28 | Congenital primary aphakia (HP:0007707) | 2.95139225 |
| 29 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.93980112 |
| 30 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.93980112 |
| 31 | Progressive macrocephaly (HP:0004481) | 2.86974438 |
| 32 | Hyperventilation (HP:0002883) | 2.84612640 |
| 33 | Mitochondrial inheritance (HP:0001427) | 2.81993381 |
| 34 | Nephrogenic diabetes insipidus (HP:0009806) | 2.77538922 |
| 35 | Dialeptic seizures (HP:0011146) | 2.69854796 |
| 36 | Gaze-evoked nystagmus (HP:0000640) | 2.67334317 |
| 37 | Retinal dysplasia (HP:0007973) | 2.67046056 |
| 38 | Abnormality of the fovea (HP:0000493) | 2.64774152 |
| 39 | Progressive inability to walk (HP:0002505) | 2.62250835 |
| 40 | Generalized tonic-clonic seizures (HP:0002069) | 2.62040121 |
| 41 | Optic disc pallor (HP:0000543) | 2.60381140 |
| 42 | Nephronophthisis (HP:0000090) | 2.56832781 |
| 43 | Abnormal hair whorl (HP:0010721) | 2.55958852 |
| 44 | Renal cortical cysts (HP:0000803) | 2.55162687 |
| 45 | Albinism (HP:0001022) | 2.54978347 |
| 46 | Hepatocellular necrosis (HP:0001404) | 2.52353300 |
| 47 | Congenital stationary night blindness (HP:0007642) | 2.50735480 |
| 48 | Acute encephalopathy (HP:0006846) | 2.50482845 |
| 49 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.45546850 |
| 50 | Tubulointerstitial nephritis (HP:0001970) | 2.44922287 |
| 51 | Pancreatic fibrosis (HP:0100732) | 2.44530710 |
| 52 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.43954454 |
| 53 | Inability to walk (HP:0002540) | 2.41198146 |
| 54 | Prolonged QT interval (HP:0001657) | 2.40690123 |
| 55 | Status epilepticus (HP:0002133) | 2.39742770 |
| 56 | Abnormal EKG (HP:0003115) | 2.32904064 |
| 57 | Truncal ataxia (HP:0002078) | 2.30245556 |
| 58 | Increased CSF lactate (HP:0002490) | 2.29692995 |
| 59 | Poor eye contact (HP:0000817) | 2.28973020 |
| 60 | Mutism (HP:0002300) | 2.27586508 |
| 61 | True hermaphroditism (HP:0010459) | 2.27307441 |
| 62 | Genital tract atresia (HP:0001827) | 2.24565801 |
| 63 | Attenuation of retinal blood vessels (HP:0007843) | 2.23038273 |
| 64 | Protruding tongue (HP:0010808) | 2.21416377 |
| 65 | Anxiety (HP:0000739) | 2.19917587 |
| 66 | Bony spicule pigmentary retinopathy (HP:0007737) | 2.19496190 |
| 67 | Abnormality of the renal cortex (HP:0011035) | 2.18842903 |
| 68 | Generalized hypopigmentation of hair (HP:0011358) | 2.17249163 |
| 69 | Pancreatic cysts (HP:0001737) | 2.17180099 |
| 70 | Vaginal atresia (HP:0000148) | 2.14272960 |
| 71 | Poor coordination (HP:0002370) | 2.12847611 |
| 72 | Action tremor (HP:0002345) | 2.12493010 |
| 73 | Cerebral hypomyelination (HP:0006808) | 2.10829249 |
| 74 | Generalized aminoaciduria (HP:0002909) | 2.10677247 |
| 75 | Spastic gait (HP:0002064) | 2.08408352 |
| 76 | Hemiparesis (HP:0001269) | 2.06079435 |
| 77 | Rhinitis (HP:0012384) | 2.05773955 |
| 78 | Abnormality of midbrain morphology (HP:0002418) | 2.01857175 |
| 79 | Molar tooth sign on MRI (HP:0002419) | 2.01857175 |
| 80 | Decreased central vision (HP:0007663) | 2.01439317 |
| 81 | Spastic tetraplegia (HP:0002510) | 2.01059105 |
| 82 | Increased hepatocellular lipid droplets (HP:0006565) | 2.00339757 |
| 83 | Fair hair (HP:0002286) | 1.99791582 |
| 84 | Epileptiform EEG discharges (HP:0011182) | 1.99258703 |
| 85 | Absent speech (HP:0001344) | 1.98596353 |
| 86 | CNS hypomyelination (HP:0003429) | 1.96218698 |
| 87 | Pachygyria (HP:0001302) | 1.95721783 |
| 88 | Abnormality of the renal medulla (HP:0100957) | 1.94554993 |
| 89 | Delusions (HP:0000746) | 1.94459760 |
| 90 | Hypsarrhythmia (HP:0002521) | 1.93921437 |
| 91 | Hemiplegia (HP:0002301) | 1.93459047 |
| 92 | Aplasia/Hypoplasia of the lens (HP:0008063) | 1.92110524 |
| 93 | Left ventricular hypertrophy (HP:0001712) | 1.90897090 |
| 94 | EEG with generalized epileptiform discharges (HP:0011198) | 1.90772634 |
| 95 | Thyroid-stimulating hormone excess (HP:0002925) | 1.89807585 |
| 96 | Abolished electroretinogram (ERG) (HP:0000550) | 1.89132565 |
| 97 | Drooling (HP:0002307) | 1.88930056 |
| 98 | Excessive salivation (HP:0003781) | 1.88930056 |
| 99 | Impaired vibration sensation in the lower limbs (HP:0002166) | 1.88579026 |
| 100 | Ankle clonus (HP:0011448) | 1.88071687 |
| 101 | Impaired social interactions (HP:0000735) | 1.87850931 |
| 102 | Abnormal social behavior (HP:0012433) | 1.87850931 |
| 103 | Syncope (HP:0001279) | 1.87700445 |
| 104 | Cystic liver disease (HP:0006706) | 1.87406224 |
| 105 | Chronic hepatic failure (HP:0100626) | 1.87126026 |
| 106 | Lissencephaly (HP:0001339) | 1.86339644 |
| 107 | Calf muscle hypertrophy (HP:0008981) | 1.86248295 |
| 108 | Papilledema (HP:0001085) | 1.85964392 |
| 109 | Muscle hypertrophy of the lower extremities (HP:0008968) | 1.84564466 |
| 110 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.84068871 |
| 111 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.84068871 |
| 112 | Type II lissencephaly (HP:0007260) | 1.82628787 |
| 113 | Agitation (HP:0000713) | 1.82441619 |
| 114 | Focal dystonia (HP:0004373) | 1.82179614 |
| 115 | Dyschromatopsia (HP:0007641) | 1.80851348 |
| 116 | Scotoma (HP:0000575) | 1.80468961 |
| 117 | Depression (HP:0000716) | 1.79880577 |
| 118 | Postaxial foot polydactyly (HP:0001830) | 1.78048555 |
| 119 | Specific learning disability (HP:0001328) | 1.77729706 |
| 120 | Central scotoma (HP:0000603) | 1.77404818 |
| 121 | Amblyopia (HP:0000646) | 1.77193291 |
| 122 | Torticollis (HP:0000473) | 1.76732472 |
| 123 | Urinary bladder sphincter dysfunction (HP:0002839) | 1.76663090 |
| 124 | Blue irides (HP:0000635) | 1.76207360 |
| 125 | Abnormal drinking behavior (HP:0030082) | 1.75176980 |
| 126 | Polydipsia (HP:0001959) | 1.75176980 |
| 127 | Abnormality of the corticospinal tract (HP:0002492) | 1.73322716 |
| 128 | Exercise intolerance (HP:0003546) | 1.73227750 |
| 129 | Diplopia (HP:0000651) | 1.71649606 |
| 130 | Abnormality of binocular vision (HP:0011514) | 1.71649606 |
| 131 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.71631899 |
| 132 | Atrial fibrillation (HP:0005110) | 1.71411466 |
| 133 | Hepatic necrosis (HP:0002605) | 1.71006967 |
| 134 | Primary atrial arrhythmia (HP:0001692) | 1.69335198 |
| 135 | Ventricular fibrillation (HP:0001663) | 1.68067814 |
| 136 | Esotropia (HP:0000565) | 1.68023012 |
| 137 | Postaxial hand polydactyly (HP:0001162) | 1.67391578 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP2K7 | 3.97137897 |
| 2 | NTRK3 | 3.95277951 |
| 3 | TNIK | 3.26546907 |
| 4 | MAP3K4 | 3.19849466 |
| 5 | CASK | 3.09052560 |
| 6 | EPHA4 | 2.78159717 |
| 7 | MARK1 | 2.76312145 |
| 8 | MAP3K12 | 2.60471157 |
| 9 | FRK | 2.57104387 |
| 10 | TAOK3 | 2.25697048 |
| 11 | PAK3 | 2.13361806 |
| 12 | PAK6 | 2.10288814 |
| 13 | BCKDK | 2.09397993 |
| 14 | INSRR | 2.06825131 |
| 15 | MAP4K2 | 1.99682061 |
| 16 | MUSK | 1.97179814 |
| 17 | MAPK13 | 1.89660527 |
| 18 | TIE1 | 1.87361021 |
| 19 | NTRK2 | 1.85830121 |
| 20 | MINK1 | 1.60239149 |
| 21 | MAP2K4 | 1.59692732 |
| 22 | STK16 | 1.49396526 |
| 23 | BMPR1B | 1.48685891 |
| 24 | RIPK4 | 1.47568047 |
| 25 | GRK7 | 1.44386115 |
| 26 | PNCK | 1.35430422 |
| 27 | PLK2 | 1.35113000 |
| 28 | SIK2 | 1.33256272 |
| 29 | GRK1 | 1.22269221 |
| 30 | GRK5 | 1.21229823 |
| 31 | BMPR2 | 1.15807023 |
| 32 | YES1 | 1.15093850 |
| 33 | MAP3K11 | 1.15028545 |
| 34 | SGK2 | 1.14307336 |
| 35 | FES | 1.12754708 |
| 36 | CSNK1A1L | 1.12180593 |
| 37 | CCNB1 | 1.11797403 |
| 38 | NEK6 | 1.11327329 |
| 39 | NME1 | 1.11271760 |
| 40 | DAPK2 | 1.10782269 |
| 41 | CDK5 | 1.09874098 |
| 42 | TNK2 | 1.08502730 |
| 43 | UHMK1 | 1.06377369 |
| 44 | PHKG2 | 1.04826407 |
| 45 | PHKG1 | 1.04826407 |
| 46 | EPHA3 | 1.04290479 |
| 47 | CAMK2A | 1.03550233 |
| 48 | PRPF4B | 1.02062942 |
| 49 | PINK1 | 0.99234356 |
| 50 | CSNK1G1 | 0.98525200 |
| 51 | ADRBK2 | 0.97847529 |
| 52 | CDK19 | 0.96903918 |
| 53 | MAP3K9 | 0.94241262 |
| 54 | LMTK2 | 0.93782697 |
| 55 | PRKCG | 0.92548895 |
| 56 | TXK | 0.92511960 |
| 57 | SGK223 | 0.91240899 |
| 58 | SGK494 | 0.91240899 |
| 59 | CAMK1 | 0.89199810 |
| 60 | CAMK2B | 0.87882608 |
| 61 | AKT3 | 0.86813312 |
| 62 | DYRK2 | 0.83469198 |
| 63 | DAPK1 | 0.83106207 |
| 64 | PKN1 | 0.82637529 |
| 65 | CAMK2D | 0.80102267 |
| 66 | STK38 | 0.78701023 |
| 67 | PDK3 | 0.77504076 |
| 68 | PDK4 | 0.77504076 |
| 69 | PRKCZ | 0.77425272 |
| 70 | ARAF | 0.77179556 |
| 71 | LIMK1 | 0.77090204 |
| 72 | ZAK | 0.76476966 |
| 73 | NTRK1 | 0.74998669 |
| 74 | MYLK | 0.74918981 |
| 75 | DYRK1A | 0.73947701 |
| 76 | PRKCE | 0.72941365 |
| 77 | OXSR1 | 0.72870436 |
| 78 | MKNK2 | 0.72127561 |
| 79 | KSR1 | 0.71707486 |
| 80 | OBSCN | 0.70517752 |
| 81 | KSR2 | 0.68863890 |
| 82 | STK11 | 0.67948807 |
| 83 | SGK1 | 0.67110240 |
| 84 | IRAK3 | 0.66952550 |
| 85 | PIK3CA | 0.66063515 |
| 86 | PRKD2 | 0.65760513 |
| 87 | WNK1 | 0.65006418 |
| 88 | PRKCH | 0.64837663 |
| 89 | MAPKAPK5 | 0.64189966 |
| 90 | STK39 | 0.64003726 |
| 91 | BCR | 0.63252429 |
| 92 | CAMKK2 | 0.61710593 |
| 93 | WNK4 | 0.61322365 |
| 94 | MAPKAPK3 | 0.57670015 |
| 95 | BRD4 | 0.57218091 |
| 96 | MAP2K6 | 0.54907085 |
| 97 | CAMK2G | 0.53072787 |
| 98 | PRKG1 | 0.52485597 |
| 99 | MAP3K6 | 0.52340376 |
| 100 | SGK3 | 0.51763864 |
| 101 | SYK | 0.51636334 |
| 102 | PDK2 | 0.51292261 |
| 103 | MAPK15 | 0.50938587 |
| 104 | CSNK1G2 | 0.50802867 |
| 105 | ADRBK1 | 0.50592486 |
| 106 | SRPK1 | 0.49211841 |
| 107 | IRAK2 | 0.48924791 |
| 108 | TLK1 | 0.48923404 |
| 109 | CSNK1A1 | 0.47967794 |
| 110 | SIK3 | 0.47770110 |
| 111 | PRKACA | 0.45491650 |
| 112 | TESK1 | 0.45484984 |
| 113 | PRKCA | 0.44948386 |
| 114 | IRAK4 | 0.44490735 |
| 115 | CDK3 | 0.43931922 |
| 116 | MAP3K2 | 0.43514337 |
| 117 | RAF1 | 0.43169804 |
| 118 | CSNK1G3 | 0.43160392 |
| 119 | PTK2B | 0.42616707 |
| 120 | ERBB2 | 0.41861227 |
| 121 | CDK14 | 0.40493494 |
| 122 | DYRK1B | 0.40012087 |
| 123 | CSNK1D | 0.39539527 |
| 124 | CAMK4 | 0.39477017 |
| 125 | CAMKK1 | 0.39261549 |
| 126 | WNK3 | 0.38645375 |
| 127 | TAOK1 | 0.38147817 |
| 128 | PRKD1 | 0.37984324 |
| 129 | RPS6KA3 | 0.37830892 |
| 130 | PRKD3 | 0.37767540 |
| 131 | HIPK2 | 0.37438009 |
| 132 | MAPK7 | 0.37366056 |
| 133 | PLK4 | 0.36444072 |
| 134 | STK24 | 0.36312762 |
| 135 | MARK2 | 0.36232922 |
| 136 | CDC42BPA | 0.36069529 |
| 137 | EIF2AK2 | 0.35855284 |
| 138 | MAPK12 | 0.35594891 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.07345770 |
| 2 | Phototransduction_Homo sapiens_hsa04744 | 3.01415357 |
| 3 | Olfactory transduction_Homo sapiens_hsa04740 | 2.85579865 |
| 4 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.79302040 |
| 5 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.71961334 |
| 6 | Morphine addiction_Homo sapiens_hsa05032 | 2.64961015 |
| 7 | Circadian entrainment_Homo sapiens_hsa04713 | 2.62735686 |
| 8 | Taste transduction_Homo sapiens_hsa04742 | 2.61666203 |
| 9 | GABAergic synapse_Homo sapiens_hsa04727 | 2.53511123 |
| 10 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.49608080 |
| 11 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.49277828 |
| 12 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.37386331 |
| 13 | Serotonergic synapse_Homo sapiens_hsa04726 | 2.23475061 |
| 14 | Parkinsons disease_Homo sapiens_hsa05012 | 2.22591759 |
| 15 | Long-term potentiation_Homo sapiens_hsa04720 | 2.19543551 |
| 16 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.06394752 |
| 17 | Insulin secretion_Homo sapiens_hsa04911 | 2.03530787 |
| 18 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.03451002 |
| 19 | Alzheimers disease_Homo sapiens_hsa05010 | 2.01937269 |
| 20 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.90862083 |
| 21 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.88506153 |
| 22 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.87490445 |
| 23 | Salivary secretion_Homo sapiens_hsa04970 | 1.84970437 |
| 24 | Cocaine addiction_Homo sapiens_hsa05030 | 1.81374441 |
| 25 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.80342436 |
| 26 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.75068074 |
| 27 | Huntingtons disease_Homo sapiens_hsa05016 | 1.71872746 |
| 28 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.65832275 |
| 29 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.64329412 |
| 30 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.64037984 |
| 31 | Renin secretion_Homo sapiens_hsa04924 | 1.63362739 |
| 32 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.47967641 |
| 33 | Long-term depression_Homo sapiens_hsa04730 | 1.47449088 |
| 34 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.43034778 |
| 35 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.34323917 |
| 36 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.31972167 |
| 37 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.30747122 |
| 38 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.28786537 |
| 39 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.15658423 |
| 40 | Pancreatic secretion_Homo sapiens_hsa04972 | 1.15633655 |
| 41 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.12706855 |
| 42 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.11132959 |
| 43 | Peroxisome_Homo sapiens_hsa04146 | 1.10311003 |
| 44 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.08943236 |
| 45 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.08086287 |
| 46 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.02015709 |
| 47 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.01710232 |
| 48 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.01709209 |
| 49 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.00415813 |
| 50 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.96792004 |
| 51 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.96444480 |
| 52 | Gap junction_Homo sapiens_hsa04540 | 0.96441893 |
| 53 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.96161842 |
| 54 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.95804838 |
| 55 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.94074246 |
| 56 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.93316480 |
| 57 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.88662308 |
| 58 | Histidine metabolism_Homo sapiens_hsa00340 | 0.88397454 |
| 59 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.87087046 |
| 60 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.86729571 |
| 61 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.85273443 |
| 62 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.84541123 |
| 63 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.83715207 |
| 64 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.82227685 |
| 65 | Alcoholism_Homo sapiens_hsa05034 | 0.82013415 |
| 66 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.80594470 |
| 67 | Axon guidance_Homo sapiens_hsa04360 | 0.79129269 |
| 68 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.78663373 |
| 69 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.76224263 |
| 70 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.74830974 |
| 71 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.74159514 |
| 72 | Melanogenesis_Homo sapiens_hsa04916 | 0.72594849 |
| 73 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.71837839 |
| 74 | ABC transporters_Homo sapiens_hsa02010 | 0.68520804 |
| 75 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.68096183 |
| 76 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.67794977 |
| 77 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.66616747 |
| 78 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.65944371 |
| 79 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.65826066 |
| 80 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.65459211 |
| 81 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.60195672 |
| 82 | Protein export_Homo sapiens_hsa03060 | 0.57307452 |
| 83 | Circadian rhythm_Homo sapiens_hsa04710 | 0.54090547 |
| 84 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.53695090 |
| 85 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.50749287 |
| 86 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.48853055 |
| 87 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.48590954 |
| 88 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.48469027 |
| 89 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.48430318 |
| 90 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.48030565 |
| 91 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.47865909 |
| 92 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.47660333 |
| 93 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.45561332 |
| 94 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.45210748 |
| 95 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.44529925 |
| 96 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.44519741 |
| 97 | Purine metabolism_Homo sapiens_hsa00230 | 0.43276794 |
| 98 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.41269743 |
| 99 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.41141981 |
| 100 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.40934814 |
| 101 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.40814568 |
| 102 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.38319923 |
| 103 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.36930065 |
| 104 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.36683489 |
| 105 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.36435144 |
| 106 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.36382089 |
| 107 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.35927295 |
| 108 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.35771292 |
| 109 | Metabolic pathways_Homo sapiens_hsa01100 | 0.35284830 |
| 110 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.35069859 |
| 111 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.34872321 |
| 112 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.34618941 |
| 113 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.34490089 |
| 114 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.34469142 |
| 115 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.34199595 |
| 116 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.33611836 |
| 117 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.32623469 |
| 118 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.32030758 |
| 119 | Bile secretion_Homo sapiens_hsa04976 | 0.32026039 |
| 120 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.31181661 |
| 121 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.30953809 |
| 122 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.28682485 |
| 123 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.28292487 |
| 124 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.26713333 |
| 125 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.26706480 |
| 126 | Glioma_Homo sapiens_hsa05214 | 0.25699457 |
| 127 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.20224778 |
| 128 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.15747828 |
| 129 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.14469834 |
| 130 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.13644392 |
| 131 | Basal transcription factors_Homo sapiens_hsa03022 | 0.12991632 |
| 132 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.12401549 |
| 133 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.12002482 |
| 134 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.11831179 |

