LYSMD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal action potential propagation (GO:0019227)5.07277313
2positive regulation of gamma-delta T cell activation (GO:0046645)4.99332593
3synaptic vesicle exocytosis (GO:0016079)4.87363597
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.83712592
5regulation of B cell receptor signaling pathway (GO:0050855)4.82789765
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.80863558
7antigen processing and presentation of endogenous antigen (GO:0019883)4.75016068
8regulation of synaptic vesicle exocytosis (GO:2000300)4.65739047
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.65238817
10negative regulation of cell killing (GO:0031342)4.61487164
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.61487164
12synaptic vesicle maturation (GO:0016188)4.58049782
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.45773232
14immunoglobulin mediated immune response (GO:0016064)4.42574969
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.28749329
16protein maturation by protein folding (GO:0022417)4.25172099
17neutrophil activation involved in immune response (GO:0002283)4.24090674
18glutamate secretion (GO:0014047)4.22985813
19regulation of synaptic vesicle transport (GO:1902803)4.22382422
20detection of calcium ion (GO:0005513)4.13617481
21positive regulation by symbiont of host defense response (GO:0052509)4.10408562
22modulation by symbiont of host defense response (GO:0052031)4.10408562
23modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.10408562
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.10408562
25positive regulation by organism of defense response of other organism involved in symbiotic interact4.10408562
26modulation by symbiont of host immune response (GO:0052553)4.10408562
27type I interferon signaling pathway (GO:0060337)3.92970549
28cellular response to type I interferon (GO:0071357)3.92970549
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.92112590
30vocalization behavior (GO:0071625)3.91265158
31response to peptidoglycan (GO:0032494)3.90795918
32response to type I interferon (GO:0034340)3.90745106
33COPI coating of Golgi vesicle (GO:0048205)3.89977275
34Golgi transport vesicle coating (GO:0048200)3.89977275
35neuron cell-cell adhesion (GO:0007158)3.79366292
36synaptic vesicle docking involved in exocytosis (GO:0016081)3.75552950
37interferon-gamma-mediated signaling pathway (GO:0060333)3.68886252
38detection of other organism (GO:0098543)3.67109996
39detection of bacterium (GO:0016045)3.61557256
40negative regulation of interleukin-12 production (GO:0032695)3.61406273
41positive regulation of B cell differentiation (GO:0045579)3.60707234
42macrophage activation involved in immune response (GO:0002281)3.59955954
43neurotransmitter secretion (GO:0007269)3.58944413
44neuromuscular process controlling posture (GO:0050884)3.55786887
45locomotory exploration behavior (GO:0035641)3.55552924
46B cell mediated immunity (GO:0019724)3.54202220
47regulation of vesicle fusion (GO:0031338)3.51073677
48regulation of gamma-delta T cell activation (GO:0046643)3.48196335
49positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.47790461
50ionotropic glutamate receptor signaling pathway (GO:0035235)3.46095209
51regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.45856819
52protein localization to synapse (GO:0035418)3.42846829
53B cell receptor signaling pathway (GO:0050853)3.42808572
54regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.41094946
55regulation of dendritic cell antigen processing and presentation (GO:0002604)3.40801915
56positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.40152212
57activation of protein kinase A activity (GO:0034199)3.35486682
58synaptic transmission, glutamatergic (GO:0035249)3.34551070
59defense response to protozoan (GO:0042832)3.32205917
60cellular response to interleukin-15 (GO:0071350)3.31804617
61regulation of glutamate receptor signaling pathway (GO:1900449)3.30349537
62response to interleukin-15 (GO:0070672)3.27555427
63startle response (GO:0001964)3.27036497
64neuron-neuron synaptic transmission (GO:0007270)3.24555685
65mature B cell differentiation involved in immune response (GO:0002313)3.24434001
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.24214547
67postsynaptic membrane organization (GO:0001941)3.23642661
68negative regulation of synaptic transmission, GABAergic (GO:0032229)3.23552779
69leukocyte aggregation (GO:0070486)3.21391894
70glutamate receptor signaling pathway (GO:0007215)3.21118818
71gamma-aminobutyric acid signaling pathway (GO:0007214)3.20249332
72T cell migration (GO:0072678)3.19272158
73insulin secretion (GO:0030073)3.18742231
74response to protozoan (GO:0001562)3.18473659
75response to host immune response (GO:0052572)3.18327061
76response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.18327061
77negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.15391344
78myeloid cell activation involved in immune response (GO:0002275)3.14909021
79negative regulation of erythrocyte differentiation (GO:0045647)3.14714540
80positive regulation of vesicle fusion (GO:0031340)3.14484412
81neutrophil activation (GO:0042119)3.13657288
82positive regulation of antigen processing and presentation (GO:0002579)3.13486838
83regulation of antigen processing and presentation (GO:0002577)3.13235407
84peptide hormone processing (GO:0016486)3.12850474
85regulation of alpha-beta T cell proliferation (GO:0046640)3.12131342
86lipopolysaccharide-mediated signaling pathway (GO:0031663)3.08780779
87regulation of gamma-delta T cell differentiation (GO:0045586)3.08014403
88negative regulation of cation channel activity (GO:2001258)3.07613950
89positive regulation of insulin secretion (GO:0032024)3.06999465
90cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.06160677
91negative regulation of lymphocyte mediated immunity (GO:0002707)3.05468500
92negative regulation of T cell mediated immunity (GO:0002710)3.04923570
93regulation of B cell apoptotic process (GO:0002902)3.03909151
94negative thymic T cell selection (GO:0045060)3.03699422
95positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.03470516
96positive thymic T cell selection (GO:0045059)3.03385189
97positive regulation of type 2 immune response (GO:0002830)3.02297683
98mature B cell differentiation (GO:0002335)3.02050795
99presynaptic membrane assembly (GO:0097105)3.01636794
100regulation of neuronal synaptic plasticity (GO:0048168)3.01446936
101regulation of amyloid precursor protein catabolic process (GO:1902991)3.00723357
102long-term synaptic potentiation (GO:0060291)3.00662860
103membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.00468111
104detection of external biotic stimulus (GO:0098581)2.99947575
105exploration behavior (GO:0035640)2.99561923
106regulation of neurotransmitter secretion (GO:0046928)2.99276957
107regulation of B cell differentiation (GO:0045577)2.98935798
108regulation of insulin secretion (GO:0050796)2.98500637
109regulation of type B pancreatic cell apoptotic process (GO:2000674)2.97601228
110regulation of long-term neuronal synaptic plasticity (GO:0048169)2.97310743
111granulocyte activation (GO:0036230)2.96151870
112energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.95389376
113ATP hydrolysis coupled proton transport (GO:0015991)2.95389376
114positive regulation of membrane potential (GO:0045838)2.94206841
115negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.93446130
116neurotransmitter transport (GO:0006836)2.93364494
117regulation of interferon-beta biosynthetic process (GO:0045357)2.93012903
118positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.92497873
119negative T cell selection (GO:0043383)2.92114982
120regulation of T-helper 1 cell differentiation (GO:0045625)2.91490813
121response to muramyl dipeptide (GO:0032495)2.91374160
122protein localization to Golgi apparatus (GO:0034067)2.90571945
123innervation (GO:0060384)2.90033385
124regulation of mast cell degranulation (GO:0043304)2.88699571
125microglial cell activation (GO:0001774)2.87479602
126regulation of T cell mediated cytotoxicity (GO:0001914)2.87462307
127regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.87320402
128negative regulation of calcium ion transmembrane transport (GO:1903170)2.87052850
129negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.87052850
130calcium-mediated signaling using intracellular calcium source (GO:0035584)2.86690610
131inositol phosphate catabolic process (GO:0071545)2.86249876
132NIK/NF-kappaB signaling (GO:0038061)2.86052789
133germinal center formation (GO:0002467)2.85357428
134mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.84589666
135negative regulation of leukocyte mediated immunity (GO:0002704)2.83398573
136mast cell activation (GO:0045576)2.83192540
137cellular potassium ion homeostasis (GO:0030007)2.81970396
138cellular response to glucagon stimulus (GO:0071377)2.80395941
139regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.79707896
140regulation of excitatory postsynaptic membrane potential (GO:0060079)2.79661172
141positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.79213911
142negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.78733347
143positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.77801293
144regulation of interferon-alpha production (GO:0032647)2.76377839
145calcium ion-dependent exocytosis (GO:0017156)2.75591486
146leukocyte degranulation (GO:0043299)2.75567780
147cellular response to interferon-gamma (GO:0071346)2.75191341
148response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.74843193
149response to host (GO:0075136)2.74843193
150response to host defenses (GO:0052200)2.74843193
151macrophage activation (GO:0042116)2.74296521
152regulation of neurotransmitter transport (GO:0051588)2.73774775
153synaptic vesicle endocytosis (GO:0048488)2.73014282
154regulation of synapse structural plasticity (GO:0051823)2.72994509
155regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.72375637
156positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.72054999
157cell communication by electrical coupling (GO:0010644)2.71291541
158positive regulation of synapse maturation (GO:0090129)2.71244009
159transferrin transport (GO:0033572)2.69939667
160establishment of synaptic vesicle localization (GO:0097480)2.69787735
161synaptic vesicle transport (GO:0048489)2.69787735
162positive regulation of interferon-alpha production (GO:0032727)2.69767971
163regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.69626487
164regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.69202063
165presynaptic membrane organization (GO:0097090)2.69163320
166membrane depolarization during action potential (GO:0086010)2.68983519
167regulation of peptide hormone secretion (GO:0090276)2.68853542
168positive regulation of T cell mediated cytotoxicity (GO:0001916)2.67739972
169regulation of synaptic plasticity (GO:0048167)2.67629250
170regulation of peptide secretion (GO:0002791)2.67361520
171T-helper 1 type immune response (GO:0042088)2.67206204
172regulation of beta-amyloid formation (GO:1902003)2.67154520
173positive regulation of interleukin-10 production (GO:0032733)2.66988817
174negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.66629658
175neurotransmitter-gated ion channel clustering (GO:0072578)2.66380110
176positive regulation of interleukin-17 production (GO:0032740)2.66199084
177purine nucleotide salvage (GO:0032261)2.66023805
178regulation of germinal center formation (GO:0002634)2.65368652
179regulation of calcium ion-dependent exocytosis (GO:0017158)2.64462870
180regulation of mast cell activation involved in immune response (GO:0033006)2.64271098
181positive regulation of amino acid transport (GO:0051957)2.64114418
182detection of molecule of bacterial origin (GO:0032490)2.63989895
183signal release (GO:0023061)2.63836837
184regulation of postsynaptic membrane potential (GO:0060078)2.63726596
185regulation of neurotransmitter levels (GO:0001505)2.63457641
186long-term memory (GO:0007616)2.62570276
187tolerance induction (GO:0002507)2.62085866
188regulation of oxidative phosphorylation (GO:0002082)2.61962282
189response to interferon-gamma (GO:0034341)2.61780629
190regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.61652969
191transmission of nerve impulse (GO:0019226)2.61640732
192retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.61372953
193regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.60329793
194response to interferon-beta (GO:0035456)2.59724844
195regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.59560609
196positive regulation of exocytosis (GO:0045921)2.59546271
197cerebellar Purkinje cell differentiation (GO:0021702)2.59370614
198negative regulation of heart rate (GO:0010459)2.58993169
199regulation of type 2 immune response (GO:0002828)2.58615037
200negative regulation of innate immune response (GO:0045824)2.56262121

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.73749525
2EZH2_22144423_ChIP-Seq_EOC_Human5.85675849
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.24312591
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.27323202
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.80558414
6GBX2_23144817_ChIP-Seq_PC3_Human3.72544044
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.63704938
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.50139546
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.32610256
10* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.31201797
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13346760
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98703467
13SCL_19346495_ChIP-Seq_HPC-7_Human2.96034148
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.84509639
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.84446929
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.81562031
17* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.80870040
18REST_21632747_ChIP-Seq_MESCs_Mouse2.76584139
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.68823403
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.68341538
21RUNX_20019798_ChIP-Seq_JUKART_Human2.66939557
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62156391
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.62024254
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.56442053
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56215200
26* MYB_26560356_Chip-Seq_TH2_Human2.53548922
27* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50398010
28SPI1_23547873_ChIP-Seq_NB4_Human2.46862171
29* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40438252
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39068185
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38842372
32EZH2_27304074_Chip-Seq_ESCs_Mouse2.38809068
33VDR_21846776_ChIP-Seq_THP-1_Human2.36324013
34EZH2_18974828_ChIP-Seq_MESCs_Mouse2.34425056
35RNF2_18974828_ChIP-Seq_MESCs_Mouse2.34425056
36REST_18959480_ChIP-ChIP_MESCs_Mouse2.33703575
37MYB_21317192_ChIP-Seq_ERMYB_Mouse2.33279554
38RARB_27405468_Chip-Seq_BRAIN_Mouse2.30560603
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.28754681
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.27655781
41VDR_24763502_ChIP-Seq_THP-1_Human2.27413519
42EZH2_27294783_Chip-Seq_ESCs_Mouse2.19397197
43STAT4_19710469_ChIP-ChIP_TH1__Mouse2.17427928
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13608746
45SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09862135
46EED_16625203_ChIP-ChIP_MESCs_Mouse2.07026776
47MAF_26560356_Chip-Seq_TH1_Human2.04890288
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.04654791
49EGR1_19374776_ChIP-ChIP_THP-1_Human2.02887540
50* SPI1_23127762_ChIP-Seq_K562_Human2.01871186
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.98431175
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.97751922
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.96356326
54GATA1_22025678_ChIP-Seq_K562_Human1.95572024
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95514488
56MYC_22102868_ChIP-Seq_BL_Human1.95226662
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.91860749
58TAF15_26573619_Chip-Seq_HEK293_Human1.89855205
59* MYB_26560356_Chip-Seq_TH1_Human1.86709186
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.86316999
61DROSHA_22980978_ChIP-Seq_HELA_Human1.85896202
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.85530135
63* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.85419085
64UTX_26944678_Chip-Seq_JUKART_Human1.84112333
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.83375132
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82418378
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81843123
68GATA3_27048872_Chip-Seq_THYMUS_Human1.80465295
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80450464
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79286849
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.74791742
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71101966
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.65017665
74SMAD4_21799915_ChIP-Seq_A2780_Human1.64137507
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62538592
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.61465915
77VDR_24787735_ChIP-Seq_THP-1_Human1.60943377
78VDR_22108803_ChIP-Seq_LS180_Human1.59352437
79ZNF274_21170338_ChIP-Seq_K562_Hela1.58206463
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.58120269
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.58027495
82* MAF_26560356_Chip-Seq_TH2_Human1.54214047
83IGF1R_20145208_ChIP-Seq_DFB_Human1.51735915
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50105899
85* GATA3_26560356_Chip-Seq_TH2_Human1.48937273
86GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47504867
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.47159988
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.46943439
89POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46583298
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44346742
91TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.42916193
92P300_19829295_ChIP-Seq_ESCs_Human1.42892131
93MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37251739
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.35338686
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33761134
96GATA1_19941827_ChIP-Seq_MEL_Mouse1.33633065
97SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33248701
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32666872
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32044752
100SMAD_19615063_ChIP-ChIP_OVARY_Human1.31372130
101CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30157333
102TCF7_22412390_ChIP-Seq_EML_Mouse1.29854406
103AR_25329375_ChIP-Seq_VCAP_Human1.26771404
104BCL6_27268052_Chip-Seq_Bcells_Human1.26503470
105VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26239101
106BCAT_22108803_ChIP-Seq_LS180_Human1.25440522
107AR_21572438_ChIP-Seq_LNCaP_Human1.24771090
108ELF1_20517297_ChIP-Seq_JURKAT_Human1.22248689
109GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21857696
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21065356
111PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19855559
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19394820
113STAT3_23295773_ChIP-Seq_U87_Human1.19241152
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18933974
115PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16370508
116SOX2_21211035_ChIP-Seq_LN229_Gbm1.16300011
117CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15379799
118TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14933763
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14289241
120KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10832227
121PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10784303
122GATA1_19941826_ChIP-Seq_K562_Human1.10707492
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10576604
124PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10504293
125KDM2B_26808549_Chip-Seq_DND41_Human1.10262593
126PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10056517
127RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09826300
128ERG_21242973_ChIP-ChIP_JURKAT_Human1.09100270
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09070975
130SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08587045
131SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08458730
132GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08113279
133CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07994299
134CIITA_25753668_ChIP-Seq_RAJI_Human1.07681111
135KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06089406
136CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05218227
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04926304
138SMAD3_21741376_ChIP-Seq_EPCs_Human1.04682396
139PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04495946
140BCOR_27268052_Chip-Seq_Bcells_Human1.04371181
141FUS_26573619_Chip-Seq_HEK293_Human1.03665526
142RNF2_27304074_Chip-Seq_NSC_Mouse1.03561523
143SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03354825
144* REST_19997604_ChIP-ChIP_NEURONS_Mouse1.03168847
145STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01947944
146FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00908319
147CBX2_27304074_Chip-Seq_ESCs_Mouse1.00841821
148DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00623188
149RING1B_27294783_Chip-Seq_ESCs_Mouse1.00545313
150PU_27001747_Chip-Seq_BMDM_Mouse0.99949971
151GATA2_21666600_ChIP-Seq_HMVEC_Human0.99562029
152CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99087648
153SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99068068
154* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98940700
155ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98565503
156P300_27268052_Chip-Seq_Bcells_Human0.98263659
157SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98240844
158GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97989788
159KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97160740
160NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96560880
161OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95758300
162TCF4_23295773_ChIP-Seq_U87_Human0.95420462
163RUNX2_22187159_ChIP-Seq_PCA_Human0.94640312
164RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94329465
165CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94113626
166STAT1_20625510_ChIP-Seq_HELA_Human0.93415890
167MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92796482
168SMAD3_21741376_ChIP-Seq_ESCs_Human0.91296683
169RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91273437
170P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89971136
171TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89831380
172JUN_21703547_ChIP-Seq_K562_Human0.89224384
173YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88586642
174CTCF_26484167_Chip-Seq_Bcells_Mouse0.88497724
175UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88035367
176* AR_19668381_ChIP-Seq_PC3_Human0.87703573
177GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87185768
178SPI1_20517297_ChIP-Seq_HL60_Human0.87087816
179FLI1_21867929_ChIP-Seq_TH2_Mouse0.85760640
180NANOG_18555785_Chip-Seq_ESCs_Mouse0.85710381
181RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85644580
182LXR_22292898_ChIP-Seq_THP-1_Human0.84364344
183PRDM14_20953172_ChIP-Seq_ESCs_Human0.83380065
184FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82953491
185RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.81149158
186SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79258233
187SMAD4_21741376_ChIP-Seq_HESCs_Human0.78912852
188GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78327405
189CDX2_19796622_ChIP-Seq_MESCs_Mouse0.77572817
190WT1_19549856_ChIP-ChIP_CCG9911_Human0.76751837
191SMRT_27268052_Chip-Seq_Bcells_Human0.76314548
192GATA2_19941826_ChIP-Seq_K562_Human0.76258112
193AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76169465
194KDM2B_26808549_Chip-Seq_REH_Human0.76065821
195EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.74529906
196* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.74261369
197* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.73888922
198ETS1_22383799_ChIP-Seq_G1ME_Mouse0.73128434
199GATA3_26560356_Chip-Seq_TH1_Human0.71304111

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.36711035
2MP0001835_abnormal_antigen_presentation3.94277671
3MP0003880_abnormal_central_pattern3.86724918
4MP0003724_increased_susceptibility_to3.64473513
5MP0003303_peritoneal_inflammation3.58933178
6MP0002909_abnormal_adrenal_gland3.50606067
7MP0004270_analgesia3.38996398
8MP0005671_abnormal_response_to3.36261256
9MP0000013_abnormal_adipose_tissue3.24647660
10MP0003635_abnormal_synaptic_transmissio3.24215861
11MP0003436_decreased_susceptibility_to3.23924386
12MP0005000_abnormal_immune_tolerance3.07852287
13MP0010386_abnormal_urinary_bladder2.95773565
14MP0001800_abnormal_humoral_immune2.80501313
15MP0009785_altered_susceptibility_to2.80156799
16MP0002148_abnormal_hypersensitivity_rea2.75029261
17MP0002837_dystrophic_cardiac_calcinosis2.69380106
18MP0000685_abnormal_immune_system2.66949760
19MP0009745_abnormal_behavioral_response2.64604805
20MP0005387_immune_system_phenotype2.62597353
21MP0001790_abnormal_immune_system2.62597353
22MP0005025_abnormal_response_to2.56906114
23MP0001968_abnormal_touch/_nociception2.56616137
24MP0002723_abnormal_immune_serum2.51152006
25MP0002064_seizures2.48883838
26MP0002419_abnormal_innate_immunity2.47938376
27MP0002063_abnormal_learning/memory/cond2.45297737
28MP0006082_CNS_inflammation2.44077114
29MP0002452_abnormal_antigen_presenting2.40605247
30MP0002272_abnormal_nervous_system2.40307663
31MP0002734_abnormal_mechanical_nocicepti2.36955019
32MP0002420_abnormal_adaptive_immunity2.36144074
33MP0009780_abnormal_chondrocyte_physiolo2.33621196
34MP0001819_abnormal_immune_cell2.33539877
35MP0003763_abnormal_thymus_physiology2.31104227
36MP0002572_abnormal_emotion/affect_behav2.26126663
37MP0002736_abnormal_nociception_after2.23404427
38MP0006276_abnormal_autonomic_nervous2.21407363
39MP0005645_abnormal_hypothalamus_physiol2.16188954
40MP0002735_abnormal_chemical_nociception2.10788097
41MP0009046_muscle_twitch2.10379654
42MP0002733_abnormal_thermal_nociception2.09271405
43MP0003122_maternal_imprinting2.05631928
44MP0005646_abnormal_pituitary_gland2.03232345
45MP0001501_abnormal_sleep_pattern1.97686413
46MP0003806_abnormal_nucleotide_metabolis1.97434311
47MP0005379_endocrine/exocrine_gland_phen1.95247828
48MP0002398_abnormal_bone_marrow1.92521077
49MP0003283_abnormal_digestive_organ1.91169294
50MP0000465_gastrointestinal_hemorrhage1.90795183
51MP0001970_abnormal_pain_threshold1.89973387
52MP0005397_hematopoietic_system_phenotyp1.89844843
53MP0001545_abnormal_hematopoietic_system1.89844843
54MP0005464_abnormal_platelet_physiology1.89673542
55MP0003183_abnormal_peptide_metabolism1.88162261
56MP0009278_abnormal_bone_marrow1.87541785
57MP0002638_abnormal_pupillary_reflex1.83938537
58MP0000716_abnormal_immune_system1.82905105
59MP0004043_abnormal_pH_regulation1.79273007
60MP0002693_abnormal_pancreas_physiology1.77273446
61MP0002067_abnormal_sensory_capabilities1.76025810
62MP0001502_abnormal_circadian_rhythm1.75375471
63MP0001845_abnormal_inflammatory_respons1.74275845
64MP0003075_altered_response_to1.74045633
65MP0010155_abnormal_intestine_physiology1.73632459
66MP0001486_abnormal_startle_reflex1.72180302
67MP0002405_respiratory_system_inflammati1.71843859
68MP0003300_gastrointestinal_ulcer1.70876222
69MP0003172_abnormal_lysosome_physiology1.69139276
70MP0001533_abnormal_skeleton_physiology1.65645580
71MP0004145_abnormal_muscle_electrophysio1.65234790
72MP0009764_decreased_sensitivity_to1.64528009
73MP0003879_abnormal_hair_cell1.64318259
74MP0006072_abnormal_retinal_apoptosis1.63996924
75MP0001986_abnormal_taste_sensitivity1.63830115
76MP0003329_amyloid_beta_deposits1.62629400
77MP0008569_lethality_at_weaning1.61198765
78MP0002184_abnormal_innervation1.60174009
79MP0001984_abnormal_olfaction1.59599037
80MP0001440_abnormal_grooming_behavior1.59383470
81MP0000689_abnormal_spleen_morphology1.58397514
82MP0004858_abnormal_nervous_system1.56070467
83MP0002166_altered_tumor_susceptibility1.55164499
84MP0003787_abnormal_imprinting1.52480138
85MP0002557_abnormal_social/conspecific_i1.51732040
86MP0001944_abnormal_pancreas_morphology1.51345743
87MP0009333_abnormal_splenocyte_physiolog1.48365150
88MP0005310_abnormal_salivary_gland1.48235132
89MP0002722_abnormal_immune_system1.47613040
90MP0008469_abnormal_protein_level1.47371770
91MP0002429_abnormal_blood_cell1.45813963
92MP0005423_abnormal_somatic_nervous1.38665052
93MP0004947_skin_inflammation1.37537128
94MP0003866_abnormal_defecation1.37419013
95MP0001188_hyperpigmentation1.36969748
96MP0002132_abnormal_respiratory_system1.36278526
97MP0005451_abnormal_body_composition1.33507207
98MP0002877_abnormal_melanocyte_morpholog1.27297946
99MP0000678_abnormal_parathyroid_gland1.25923366
100MP0002822_catalepsy1.25392479
101MP0005058_abnormal_lysosome_morphology1.24551180
102MP0002396_abnormal_hematopoietic_system1.24246697
103MP0000955_abnormal_spinal_cord1.22655511
104MP0005084_abnormal_gallbladder_morpholo1.22111516
105MP0004811_abnormal_neuron_physiology1.21754886
106MP0003191_abnormal_cellular_cholesterol1.20426782
107MP0002006_tumorigenesis1.19199844
108MP0000703_abnormal_thymus_morphology1.18863164
109MP0004924_abnormal_behavior1.17775632
110MP0005386_behavior/neurological_phenoty1.17775632
111MP0001664_abnormal_digestion1.17316010
112MP0004510_myositis1.15915127
113MP0001905_abnormal_dopamine_level1.15340407
114MP0001873_stomach_inflammation1.14920257
115MP0004142_abnormal_muscle_tone1.13955025
116MP0005075_abnormal_melanosome_morpholog1.13663556
117MP0002066_abnormal_motor_capabilities/c1.11695085
118MP0005166_decreased_susceptibility_to1.11325121
119MP0002234_abnormal_pharynx_morphology1.10235356
120MP0001529_abnormal_vocalization1.07363681
121MP0000751_myopathy1.06609665
122MP0002882_abnormal_neuron_morphology1.06387261
123MP0000003_abnormal_adipose_tissue1.05909397
124MP0000631_abnormal_neuroendocrine_gland1.05847200
125MP0002078_abnormal_glucose_homeostasis1.05479074
126MP0003195_calcinosis1.03646049
127MP0005167_abnormal_blood-brain_barrier1.02801839
128MP0004215_abnormal_myocardial_fiber1.02136845
129MP0003633_abnormal_nervous_system0.99278615
130MP0002876_abnormal_thyroid_physiology0.97967753
131MP0001853_heart_inflammation0.96907302
132MP0002163_abnormal_gland_morphology0.96197495
133MP0008004_abnormal_stomach_pH0.95783585
134MP0005535_abnormal_body_temperature0.95161178
135MP0004085_abnormal_heartbeat0.94000214
136MP0004808_abnormal_hematopoietic_stem0.91803285
137MP0008961_abnormal_basal_metabolism0.89886412
138MP0001348_abnormal_lacrimal_gland0.89423089
139MP0002069_abnormal_eating/drinking_beha0.87366037
140MP0003656_abnormal_erythrocyte_physiolo0.87321363
141MP0008874_decreased_physiological_sensi0.86266411
142MP0001765_abnormal_ion_homeostasis0.86018284
143MP0002277_abnormal_respiratory_mucosa0.85504746
144MP0003690_abnormal_glial_cell0.83552097
145MP0002229_neurodegeneration0.83202608
146MP0002139_abnormal_hepatobiliary_system0.80413019
147MP0004036_abnormal_muscle_relaxation0.78862691
148MP0000230_abnormal_systemic_arterial0.78530041
149MP0001851_eye_inflammation0.78140351
150MP0003953_abnormal_hormone_level0.78128372
151MP0004233_abnormal_muscle_weight0.76779020
152MP0000343_altered_response_to0.76607670
153MP0003045_fibrosis0.75607106
154MP0006036_abnormal_mitochondrial_physio0.75409445
155MP0005551_abnormal_eye_electrophysiolog0.73820979
156MP0000778_abnormal_nervous_system0.73799458
157MP0002928_abnormal_bile_duct0.71898444
158MP0009763_increased_sensitivity_to0.71851821
159MP0000858_altered_metastatic_potential0.70125717
160MP0003631_nervous_system_phenotype0.69986485
161MP0002998_abnormal_bone_remodeling0.69913839
162MP0001663_abnormal_digestive_system0.68998010
163MP0002152_abnormal_brain_morphology0.67104298
164MP0000639_abnormal_adrenal_gland0.67045875
165MP0005253_abnormal_eye_physiology0.64468422
166MP0005187_abnormal_penis_morphology0.64453166
167MP0000613_abnormal_salivary_gland0.64092379
168MP0001963_abnormal_hearing_physiology0.63005630
169MP0004883_abnormal_blood_vessel0.62525474
170MP0003634_abnormal_glial_cell0.62489092
171MP0000681_abnormal_thyroid_gland0.62477015
172MP0006292_abnormal_olfactory_placode0.61875806
173MP0000604_amyloidosis0.61843225
174MP0009765_abnormal_xenobiotic_induced0.61601406
175MP0004885_abnormal_endolymph0.61250281
176MP0001270_distended_abdomen0.61005181
177MP0002138_abnormal_hepatobiliary_system0.60808287
178MP0002019_abnormal_tumor_incidence0.60723057
179MP0002751_abnormal_autonomic_nervous0.60026475
180MP0000920_abnormal_myelination0.59910224
181MP0005390_skeleton_phenotype0.58415889
182MP0002332_abnormal_exercise_endurance0.57146560
183MP0008872_abnormal_physiological_respon0.56902163
184MP0002009_preneoplasia0.55648178

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.89297202
2Stomatitis (HP:0010280)5.00546055
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.99396311
4Visual hallucinations (HP:0002367)4.85105167
5Myositis (HP:0100614)4.63513106
6Elevated erythrocyte sedimentation rate (HP:0003565)4.50541450
7Atonic seizures (HP:0010819)4.38030846
8Eczematoid dermatitis (HP:0000976)4.29410022
9Recurrent abscess formation (HP:0002722)4.22271964
10Orchitis (HP:0100796)4.17533631
11Recurrent bacterial skin infections (HP:0005406)4.06209375
12Retrobulbar optic neuritis (HP:0100654)3.98375731
13Optic neuritis (HP:0100653)3.98375731
14Abnormality of calcium-phosphate metabolism (HP:0100530)3.86746715
15Recurrent fungal infections (HP:0002841)3.84062151
16Epileptic encephalopathy (HP:0200134)3.77307971
17Myokymia (HP:0002411)3.75404319
18Pheochromocytoma (HP:0002666)3.72777276
19Meningitis (HP:0001287)3.67587473
20Focal seizures (HP:0007359)3.61772055
21Obstructive lung disease (HP:0006536)3.61204384
22Chronic obstructive pulmonary disease (HP:0006510)3.61204384
23Abnormality of macrophages (HP:0004311)3.60124347
24B lymphocytopenia (HP:0010976)3.58258532
25Neuroendocrine neoplasm (HP:0100634)3.55008486
26Mediastinal lymphadenopathy (HP:0100721)3.52771371
27Abnormality of B cell number (HP:0010975)3.51187508
28Febrile seizures (HP:0002373)3.45675561
29Absence seizures (HP:0002121)3.39320448
30Hyperinsulinemic hypoglycemia (HP:0000825)3.36850608
31Vasculitis (HP:0002633)3.13920831
32Abnormal mitochondria in muscle tissue (HP:0008316)3.11066296
33Agammaglobulinemia (HP:0004432)3.10809163
34Acute necrotizing encephalopathy (HP:0006965)3.07267213
35Recurrent viral infections (HP:0004429)3.05394341
36Symptomatic seizures (HP:0011145)3.04681163
37Gastrointestinal infarctions (HP:0005244)3.03408151
38Menstrual irregularities (HP:0000858)3.00567790
39Dialeptic seizures (HP:0011146)2.99618789
40Retinal dysplasia (HP:0007973)2.99610472
41Type II lissencephaly (HP:0007260)2.97861499
42Anxiety (HP:0000739)2.95791150
43Increased IgM level (HP:0003496)2.95540845
44Agitation (HP:0000713)2.94028631
45Panhypogammaglobulinemia (HP:0003139)2.92352779
46Encephalitis (HP:0002383)2.90482601
47Cellulitis (HP:0100658)2.89600733
48Recurrent skin infections (HP:0001581)2.89574038
49Episodic fever (HP:0001954)2.87316325
50Hypoglycemic seizures (HP:0002173)2.87145468
51Increased IgE level (HP:0003212)2.86948453
52Recurrent gram-negative bacterial infections (HP:0005420)2.85537649
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.85101426
54T lymphocytopenia (HP:0005403)2.83730596
55Autoimmune hemolytic anemia (HP:0001890)2.81225062
56Hypothermia (HP:0002045)2.81100643
57Severe combined immunodeficiency (HP:0004430)2.78976210
58Leukocytosis (HP:0001974)2.76017639
59Chronic mucocutaneous candidiasis (HP:0002728)2.74181788
60Recurrent cutaneous fungal infections (HP:0011370)2.74181788
61Generalized tonic-clonic seizures (HP:0002069)2.74040063
62Petechiae (HP:0000967)2.73938785
63Progressive cerebellar ataxia (HP:0002073)2.73371399
64Hyperventilation (HP:0002883)2.71945064
65Abnormality of T cell number (HP:0011839)2.70573975
66Pulmonary infiltrates (HP:0002113)2.69513630
67Keratoconjunctivitis sicca (HP:0001097)2.69430392
68Granulocytopenia (HP:0001913)2.65050118
69Prolonged bleeding time (HP:0003010)2.63199612
70Blue irides (HP:0000635)2.61831626
71Urticaria (HP:0001025)2.60527726
72Epileptiform EEG discharges (HP:0011182)2.60032214
73Depression (HP:0000716)2.59170911
74Progressive macrocephaly (HP:0004481)2.57759005
75Chest pain (HP:0100749)2.55322316
76Keratoconjunctivitis (HP:0001096)2.55302926
77Abnormality of T cells (HP:0002843)2.55264961
78Truncal ataxia (HP:0002078)2.54589394
79EEG with generalized epileptiform discharges (HP:0011198)2.51126149
80IgG deficiency (HP:0004315)2.50337459
81Decreased circulating renin level (HP:0003351)2.49432333
82Abnormality of glycosphingolipid metabolism (HP:0004343)2.48553780
83Abnormality of glycolipid metabolism (HP:0010969)2.48553780
84Abnormality of liposaccharide metabolism (HP:0010968)2.48553780
85Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.47598712
86Hypergammaglobulinemia (HP:0010702)2.45203652
87Spinal canal stenosis (HP:0003416)2.41700731
88Mitochondrial inheritance (HP:0001427)2.39908530
89Ankle clonus (HP:0011448)2.39335620
90Arterial thrombosis (HP:0004420)2.38728490
91Loss of speech (HP:0002371)2.38255858
92Hemoptysis (HP:0002105)2.38173649
93Gingivitis (HP:0000230)2.37412582
94Eosinophilia (HP:0001880)2.37384756
95Dysostosis multiplex (HP:0000943)2.36466096
96Increased cerebral lipofuscin (HP:0011813)2.36149734
97Ketoacidosis (HP:0001993)2.35423916
98Acute hepatic failure (HP:0006554)2.34853410
99Hypsarrhythmia (HP:0002521)2.34401034
100Supranuclear gaze palsy (HP:0000605)2.34195058
101Hyperparathyroidism (HP:0000843)2.31392160
102Action tremor (HP:0002345)2.30365055
103Hypercortisolism (HP:0001578)2.29742284
104Hemiparesis (HP:0001269)2.29642557
105Increased neuronal autofluorescent lipopigment (HP:0002074)2.29066569
106Gastrointestinal inflammation (HP:0004386)2.28055847
107Medial flaring of the eyebrow (HP:0010747)2.25290382
108Autoimmune thrombocytopenia (HP:0001973)2.23936936
109Epistaxis (HP:0000421)2.23606425
110Combined immunodeficiency (HP:0005387)2.23223298
111Sepsis (HP:0100806)2.22688257
112Inflammation of the large intestine (HP:0002037)2.22500954
113Acute encephalopathy (HP:0006846)2.22169091
114Thyroiditis (HP:0100646)2.22069804
115Pulmonary embolism (HP:0002204)2.21349593
116Dysautonomia (HP:0002459)2.20099834
117Recurrent bronchitis (HP:0002837)2.19404275
118Gait imbalance (HP:0002141)2.14070834
119Osteomyelitis (HP:0002754)2.13266281
120Progressive inability to walk (HP:0002505)2.11592555
121Abnormality of T cell physiology (HP:0011840)2.11156807
122Joint swelling (HP:0001386)2.10958417
123Spontaneous hematomas (HP:0007420)2.09805491
124Limb dystonia (HP:0002451)2.09007820
125Lymphopenia (HP:0001888)2.08437015
126Poor suck (HP:0002033)2.07158290
127Aplasia/Hypoplasia of the thymus (HP:0010515)2.06552704
128Abnormality of eosinophils (HP:0001879)2.06551399
129Abnormality of the pleura (HP:0002103)2.06410397
130Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05385436
131Abnormality of polysaccharide metabolism (HP:0011012)2.05385436
132Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05385436
133Thrombocytosis (HP:0001894)2.04935855
134Gastrointestinal stroma tumor (HP:0100723)2.04247551
135Congenital primary aphakia (HP:0007707)2.03878708
136Purpura (HP:0000979)2.02424099
137Hypertensive crisis (HP:0100735)2.01244555
138Nephrogenic diabetes insipidus (HP:0009806)2.00987967
139Urinary glycosaminoglycan excretion (HP:0003541)2.00955229
140Mucopolysacchariduria (HP:0008155)2.00955229
141Increased CSF lactate (HP:0002490)1.98955337
142Gingival bleeding (HP:0000225)1.98065465
143Anorexia (HP:0002039)1.97946586
144Vertigo (HP:0002321)1.96742254
145Verrucae (HP:0200043)1.96060030
146Papilloma (HP:0012740)1.96060030
147Fatigue (HP:0012378)1.95829052
148Abnormal eating behavior (HP:0100738)1.95759654
149Neoplasm of the peripheral nervous system (HP:0100007)1.95502989
150Cortical visual impairment (HP:0100704)1.95101941
151Hydroureter (HP:0000072)1.94887094
152Chronic diarrhea (HP:0002028)1.94726865
153Gangrene (HP:0100758)1.94504557
154Scanning speech (HP:0002168)1.94340330
155Acne (HP:0001061)1.94240001
156Psychosis (HP:0000709)1.93257430
157Megalencephaly (HP:0001355)1.92305822
158Amblyopia (HP:0000646)1.91384211
159Growth hormone excess (HP:0000845)1.91157883
160Broad-based gait (HP:0002136)1.91097878
161Recurrent pneumonia (HP:0006532)1.90647748
162Decreased activity of mitochondrial respiratory chain (HP:0008972)1.90070259
163Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.90070259
164Hepatoblastoma (HP:0002884)1.89203006
165Oligomenorrhea (HP:0000876)1.88627957
166Insulin-resistant diabetes mellitus (HP:0000831)1.87223092
167Hypoventilation (HP:0002791)1.87222187
168Neoplasm of the adrenal gland (HP:0100631)1.86870812
169Hypokalemia (HP:0002900)1.86613203
170Impaired smooth pursuit (HP:0007772)1.85622243
171Hypoglycemic coma (HP:0001325)1.83743035
172Late onset (HP:0003584)1.83100295
173Adrenal overactivity (HP:0002717)1.82901241
174Failure to thrive in infancy (HP:0001531)1.82499484
175Drooling (HP:0002307)1.79061320
176Excessive salivation (HP:0003781)1.79061320
177Gaze-evoked nystagmus (HP:0000640)1.78983594
178Hepatocellular necrosis (HP:0001404)1.78851856
179Osteomalacia (HP:0002749)1.78374771
180Abnormality of the fovea (HP:0000493)1.77917700
181Papilledema (HP:0001085)1.77457042
182Progressive neurologic deterioration (HP:0002344)1.76369204
183Poor eye contact (HP:0000817)1.75842813
184Dysmetria (HP:0001310)1.75099506
185Bradykinesia (HP:0002067)1.73948251
186Atelectasis (HP:0100750)1.72485146
187Delusions (HP:0000746)1.72018939
188Abnormality of alanine metabolism (HP:0010916)1.71511638
189Hyperalaninemia (HP:0003348)1.71511638
190Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71511638
191Myotonia (HP:0002486)1.70464050
192Restlessness (HP:0000711)1.70064587
193Diplopia (HP:0000651)1.69385392
194Abnormality of binocular vision (HP:0011514)1.69385392
195Dysdiadochokinesis (HP:0002075)1.68834965
196Hepatic necrosis (HP:0002605)1.68554412
197Muscular hypotonia of the trunk (HP:0008936)1.68536130

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.77643625
2MAP4K13.87360575
3MAP3K123.34186374
4MAP2K72.90766535
5CASK2.65165218
6MAPK152.59815326
7MAP2K32.58215482
8EPHA42.55959259
9TYK22.52802790
10TAOK32.45733558
11MAP3K142.45682317
12NTRK12.44024431
13KIT2.41388750
14CAMKK22.40081492
15MAP3K42.38984647
16TXK2.37550095
17INSRR2.35441980
18PRKD32.33008548
19BCKDK2.31765456
20MAP3K92.28033391
21MAP3K112.17202229
22ERN12.15464833
23NME22.14721667
24JAK32.12023788
25SYK2.06283747
26MINK12.05121128
27GRK62.00026612
28WNK31.95446516
29TBK11.95100629
30BLK1.94321982
31IRAK41.93338373
32ARAF1.93109699
33IKBKE1.89727486
34KSR21.84565614
35MAP3K21.75204067
36MAP3K11.73616558
37CDK191.72652725
38DAPK21.71864639
39PASK1.63063972
40CSK1.61900330
41GRK51.59731476
42MAP2K41.56885584
43BTK1.53925467
44IKBKB1.52509638
45MATK1.48697050
46DAPK11.48592177
47FLT31.48333460
48JAK11.44909221
49HIPK21.41624307
50RIPK41.40826012
51ZAP701.38779388
52CSF1R1.35496955
53IRAK31.35223377
54LYN1.33101732
55TNIK1.32338421
56UHMK11.28206903
57PLK21.27394118
58CDK51.24088994
59SCYL21.23256269
60HCK1.22146637
61PINK11.22009559
62WNK41.21126745
63PAK61.19810293
64TAOK21.19574681
65PIK3CG1.17880521
66MAP2K61.17661502
67CAMKK11.17515442
68TAOK11.17456910
69MAP3K31.15218209
70MUSK1.15034267
71LCK1.10273118
72MAPK131.09212151
73BMPR21.07730087
74PRKCG1.05896743
75JAK21.05052871
76PAK31.03147817
77NME11.01089356
78TEC1.00366995
79TESK20.98268991
80BRAF0.97441631
81PRKCH0.94607178
82NTRK20.93980515
83KSR10.93351610
84MARK10.93191002
85CAMK2A0.92380411
86ITK0.88733282
87PNCK0.88198252
88GRK70.87939820
89CAMK2D0.87635039
90PRKCQ0.87148008
91CAMK2B0.87102057
92PHKG10.86718302
93PHKG20.86718302
94STK160.85399033
95FER0.85253566
96FRK0.85223278
97ADRBK20.84711581
98IRAK10.84359145
99PRKCE0.80996678
100SIK20.80397769
101PDK10.79128510
102LMTK20.78926404
103CAMK10.78268782
104FES0.78210845
105PRPF4B0.78039724
106RET0.77686617
107SIK30.77205563
108RAF10.75987802
109TRPM70.71346469
110CCNB10.69398542
111FGR0.69303337
112MAPK70.68548304
113CSNK1G20.68203816
114AKT30.67916871
115SGK4940.66929767
116SGK2230.66929767
117CDC42BPA0.66434519
118PTK2B0.65921883
119PRKD20.61997889
120FGFR30.60663030
121CAMK2G0.60508531
122SGK20.60308234
123MYLK0.59099784
124MAP3K130.57378656
125DYRK1A0.57284721
126CDK140.56542310
127NLK0.56354799
128MAPK120.56285837
129MAP2K10.56203384
130PDPK10.55196764
131MAPK110.53896763
132MAP3K50.53624584
133ICK0.53268495
134LIMK10.51424450
135PRKACA0.49570633
136WNK10.48980152
137KDR0.48715176
138ADRBK10.48565619
139PIM10.47149421
140TNK20.44298237
141STK380.41424785
142MARK30.41172589
143CSNK1G30.40211765
144EPHA30.40062463
145FYN0.39316224
146VRK20.38990905
147CSNK1A10.38838079
148SGK10.38815722
149PRKCD0.38388412
150CDK180.38092277
151PIM20.37857486
152PRKG20.36528083
153MAP2K20.33577573
154BCR0.32505799
155CDK150.32426758
156EPHB10.31829305
157TESK10.31211533
158CDK11A0.30473891
159MAPKAPK50.30128663
160PTK20.29682127
161CSNK1A1L0.29123209
162IRAK20.29094781
163ALK0.28993451
164STK110.28979395
165SMG10.27062918
166CHUK0.26193691
167RPS6KL10.25591256
168RPS6KC10.25591256
169MAPK40.25475708
170ABL10.24757282

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.66284752
2Autoimmune thyroid disease_Homo sapiens_hsa053203.25291472
3Graft-versus-host disease_Homo sapiens_hsa053323.22615613
4Nicotine addiction_Homo sapiens_hsa050333.19309125
5Synaptic vesicle cycle_Homo sapiens_hsa047213.14394178
6Asthma_Homo sapiens_hsa053103.03501972
7Maturity onset diabetes of the young_Homo sapiens_hsa049503.00332188
8Primary immunodeficiency_Homo sapiens_hsa053402.99471987
9Leishmaniasis_Homo sapiens_hsa051402.98616225
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.95703428
11Insulin secretion_Homo sapiens_hsa049112.87544732
12Protein export_Homo sapiens_hsa030602.58660684
13GABAergic synapse_Homo sapiens_hsa047272.45401700
14Circadian entrainment_Homo sapiens_hsa047132.45210219
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.44266430
16Amphetamine addiction_Homo sapiens_hsa050312.43628769
17Long-term potentiation_Homo sapiens_hsa047202.41936282
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.38880431
19Osteoclast differentiation_Homo sapiens_hsa043802.34436394
20Staphylococcus aureus infection_Homo sapiens_hsa051502.31631762
21Vibrio cholerae infection_Homo sapiens_hsa051102.19387448
22Morphine addiction_Homo sapiens_hsa050322.18462199
23Collecting duct acid secretion_Homo sapiens_hsa049662.15755123
24Taste transduction_Homo sapiens_hsa047422.13316689
25Oxidative phosphorylation_Homo sapiens_hsa001902.13223321
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.10776780
27B cell receptor signaling pathway_Homo sapiens_hsa046622.10345020
28Toll-like receptor signaling pathway_Homo sapiens_hsa046202.07488624
29Antigen processing and presentation_Homo sapiens_hsa046122.06651162
30Glutamatergic synapse_Homo sapiens_hsa047242.03345765
31Dopaminergic synapse_Homo sapiens_hsa047281.95965654
32Tuberculosis_Homo sapiens_hsa051521.95766290
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.92318137
34Cocaine addiction_Homo sapiens_hsa050301.92194646
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.84576523
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.84424339
37Hematopoietic cell lineage_Homo sapiens_hsa046401.82252382
38Olfactory transduction_Homo sapiens_hsa047401.75219021
39Serotonergic synapse_Homo sapiens_hsa047261.72982052
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.70990833
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.67613144
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66413785
43Parkinsons disease_Homo sapiens_hsa050121.66258610
44Salivary secretion_Homo sapiens_hsa049701.66220934
45Alzheimers disease_Homo sapiens_hsa050101.64586087
46Measles_Homo sapiens_hsa051621.62287137
47Viral myocarditis_Homo sapiens_hsa054161.62256873
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57591404
49Cholinergic synapse_Homo sapiens_hsa047251.56427751
50Influenza A_Homo sapiens_hsa051641.55035905
51Herpes simplex infection_Homo sapiens_hsa051681.51110956
52SNARE interactions in vesicular transport_Homo sapiens_hsa041301.47549931
53Renin secretion_Homo sapiens_hsa049241.44800120
54Toxoplasmosis_Homo sapiens_hsa051451.44702624
55Gastric acid secretion_Homo sapiens_hsa049711.42890670
56Type I diabetes mellitus_Homo sapiens_hsa049401.39159609
57Cardiac muscle contraction_Homo sapiens_hsa042601.37822434
58T cell receptor signaling pathway_Homo sapiens_hsa046601.35714541
59Calcium signaling pathway_Homo sapiens_hsa040201.33950656
60African trypanosomiasis_Homo sapiens_hsa051431.32890095
61Long-term depression_Homo sapiens_hsa047301.32458841
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32007303
63Legionellosis_Homo sapiens_hsa051341.30432777
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22559343
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21067214
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18321232
67Oxytocin signaling pathway_Homo sapiens_hsa049211.18076307
68TNF signaling pathway_Homo sapiens_hsa046681.17824220
69GnRH signaling pathway_Homo sapiens_hsa049121.17502923
70Jak-STAT signaling pathway_Homo sapiens_hsa046301.15772685
71Malaria_Homo sapiens_hsa051441.15199682
72Type II diabetes mellitus_Homo sapiens_hsa049301.14709184
73Chemokine signaling pathway_Homo sapiens_hsa040621.14270111
74Other glycan degradation_Homo sapiens_hsa005111.12574088
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12452511
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12245211
77cAMP signaling pathway_Homo sapiens_hsa040241.11227861
78Huntingtons disease_Homo sapiens_hsa050161.07856362
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07812633
80Estrogen signaling pathway_Homo sapiens_hsa049151.04906263
81Glycosaminoglycan degradation_Homo sapiens_hsa005311.03483579
82Gap junction_Homo sapiens_hsa045401.03374877
83Pertussis_Homo sapiens_hsa051331.00750107
84Vascular smooth muscle contraction_Homo sapiens_hsa042701.00136326
85Pancreatic secretion_Homo sapiens_hsa049720.96623738
86Acute myeloid leukemia_Homo sapiens_hsa052210.96552362
87Platelet activation_Homo sapiens_hsa046110.92818605
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91699737
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91467030
90Hepatitis C_Homo sapiens_hsa051600.89457103
91Circadian rhythm_Homo sapiens_hsa047100.89190886
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88336846
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87450268
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87090185
95Dorso-ventral axis formation_Homo sapiens_hsa043200.84622154
96Sulfur metabolism_Homo sapiens_hsa009200.83667866
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83297281
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82650392
99Shigellosis_Homo sapiens_hsa051310.82453174
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82421386
101Alcoholism_Homo sapiens_hsa050340.82058843
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81699823
103Salmonella infection_Homo sapiens_hsa051320.80739006
104Glucagon signaling pathway_Homo sapiens_hsa049220.80274274
105Thyroid hormone synthesis_Homo sapiens_hsa049180.80190059
106Epstein-Barr virus infection_Homo sapiens_hsa051690.76549143
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75443708
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75221020
109Hepatitis B_Homo sapiens_hsa051610.74631344
110Melanogenesis_Homo sapiens_hsa049160.72905424
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69602238
112N-Glycan biosynthesis_Homo sapiens_hsa005100.69232307
113Glioma_Homo sapiens_hsa052140.68652043
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67544008
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.67250358
116Systemic lupus erythematosus_Homo sapiens_hsa053220.63877357
117Regulation of autophagy_Homo sapiens_hsa041400.63313020
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.63306748
119ErbB signaling pathway_Homo sapiens_hsa040120.62094503
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59983185
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59182399
122Rheumatoid arthritis_Homo sapiens_hsa053230.58515483
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58040678
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56816716
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.56792757
126Dilated cardiomyopathy_Homo sapiens_hsa054140.56652995
127Prolactin signaling pathway_Homo sapiens_hsa049170.52214967
128Inositol phosphate metabolism_Homo sapiens_hsa005620.52052106
129Insulin signaling pathway_Homo sapiens_hsa049100.51610502
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.51477815
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.48412750
132Prion diseases_Homo sapiens_hsa050200.48351450
133Oocyte meiosis_Homo sapiens_hsa041140.48234220
134MAPK signaling pathway_Homo sapiens_hsa040100.46314592
135Phototransduction_Homo sapiens_hsa047440.42690274
136Apoptosis_Homo sapiens_hsa042100.42404786
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.42347866
138Ras signaling pathway_Homo sapiens_hsa040140.41288542
139mTOR signaling pathway_Homo sapiens_hsa041500.40237735
140Choline metabolism in cancer_Homo sapiens_hsa052310.38933099
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38224282
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38080448
143HTLV-I infection_Homo sapiens_hsa051660.35749698
144Lysosome_Homo sapiens_hsa041420.35716220
145Non-small cell lung cancer_Homo sapiens_hsa052230.34730328
146Endometrial cancer_Homo sapiens_hsa052130.33187016
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31330439
148Insulin resistance_Homo sapiens_hsa049310.30753079
149Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30162263
150Viral carcinogenesis_Homo sapiens_hsa052030.29703398
151Pancreatic cancer_Homo sapiens_hsa052120.28624204
152Wnt signaling pathway_Homo sapiens_hsa043100.28541123
153AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26555732
154Renal cell carcinoma_Homo sapiens_hsa052110.25210646
155Axon guidance_Homo sapiens_hsa043600.24636968
156Phagosome_Homo sapiens_hsa041450.24106229
157Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23898351
158VEGF signaling pathway_Homo sapiens_hsa043700.23144236
159Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22008990
160Arachidonic acid metabolism_Homo sapiens_hsa005900.21437573
161Rap1 signaling pathway_Homo sapiens_hsa040150.20417850
162Endocytosis_Homo sapiens_hsa041440.19880703
163Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18116702
164Peroxisome_Homo sapiens_hsa041460.17582434
165Fructose and mannose metabolism_Homo sapiens_hsa000510.17503407

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