LYSMD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.53869024
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.53869024
3L-phenylalanine metabolic process (GO:0006558)5.02606248
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.02606248
5intestinal cholesterol absorption (GO:0030299)4.78095197
6aromatic amino acid family catabolic process (GO:0009074)4.61833921
7protein carboxylation (GO:0018214)4.54508115
8peptidyl-glutamic acid carboxylation (GO:0017187)4.54508115
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.52362764
10negative regulation of fibrinolysis (GO:0051918)4.46077889
11COPII vesicle coating (GO:0048208)4.37184522
12regulation of protein activation cascade (GO:2000257)4.32062192
13bile acid biosynthetic process (GO:0006699)4.28344478
14maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.23224102
15regulation of RIG-I signaling pathway (GO:0039535)4.21944731
16regulation of fibrinolysis (GO:0051917)4.17772834
17urea metabolic process (GO:0019627)4.17253140
18urea cycle (GO:0000050)4.17253140
19Golgi transport vesicle coating (GO:0048200)4.13868689
20COPI coating of Golgi vesicle (GO:0048205)4.13868689
21glyoxylate metabolic process (GO:0046487)4.09209636
22regulation of complement activation (GO:0030449)4.05765956
23regulation of bile acid biosynthetic process (GO:0070857)4.05715914
24complement activation, alternative pathway (GO:0006957)3.97627339
25nitrogen cycle metabolic process (GO:0071941)3.96226885
26cellular glucuronidation (GO:0052695)3.95670895
27neutrophil activation involved in immune response (GO:0002283)3.94163013
28high-density lipoprotein particle remodeling (GO:0034375)3.93290623
29cysteine metabolic process (GO:0006534)3.90271254
30triglyceride homeostasis (GO:0070328)3.89433692
31acylglycerol homeostasis (GO:0055090)3.89433692
32tryptophan metabolic process (GO:0006568)3.85582776
33necroptotic process (GO:0070266)3.85079273
34negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.84947204
35negative regulation of T-helper cell differentiation (GO:0045623)3.84947204
36sulfur amino acid catabolic process (GO:0000098)3.84038387
37NIK/NF-kappaB signaling (GO:0038061)3.78356970
38homocysteine metabolic process (GO:0050667)3.78148105
39alpha-linolenic acid metabolic process (GO:0036109)3.73362146
40bile acid metabolic process (GO:0008206)3.72663208
41regulation of triglyceride catabolic process (GO:0010896)3.67466565
42indolalkylamine catabolic process (GO:0046218)3.64618857
43tryptophan catabolic process (GO:0006569)3.64618857
44indole-containing compound catabolic process (GO:0042436)3.64618857
45tyrosine metabolic process (GO:0006570)3.62933751
46bile acid and bile salt transport (GO:0015721)3.62125529
47intestinal absorption (GO:0050892)3.61903540
48nuclear pore complex assembly (GO:0051292)3.61696472
49regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.56980202
50monoubiquitinated protein deubiquitination (GO:0035520)3.56931192
51protein retention in ER lumen (GO:0006621)3.51465660
52very-low-density lipoprotein particle assembly (GO:0034379)3.50379657
53reverse cholesterol transport (GO:0043691)3.49026888
54ER overload response (GO:0006983)3.48823228
55cholesterol efflux (GO:0033344)3.41409802
56glucuronate metabolic process (GO:0019585)3.38768981
57uronic acid metabolic process (GO:0006063)3.38768981
58kynurenine metabolic process (GO:0070189)3.37215207
59plasma lipoprotein particle assembly (GO:0034377)3.33314602
60negative regulation of protein activation cascade (GO:2000258)3.32040691
61plasma lipoprotein particle clearance (GO:0034381)3.28376758
62regulation of necroptotic process (GO:0060544)3.27692882
63interleukin-6-mediated signaling pathway (GO:0070102)3.27548850
64lysine catabolic process (GO:0006554)3.27159703
65lysine metabolic process (GO:0006553)3.27159703
66aromatic amino acid family metabolic process (GO:0009072)3.26948937
67negative regulation of cholesterol transport (GO:0032375)3.25808871
68negative regulation of sterol transport (GO:0032372)3.25808871
69iron ion import (GO:0097286)3.23518800
70lipoprotein metabolic process (GO:0042157)3.23003668
71regulation of cholesterol homeostasis (GO:2000188)3.22858980
72protein-lipid complex remodeling (GO:0034368)3.21619889
73macromolecular complex remodeling (GO:0034367)3.21619889
74plasma lipoprotein particle remodeling (GO:0034369)3.21619889
75epoxygenase P450 pathway (GO:0019373)3.19150634
76pathway-restricted SMAD protein phosphorylation (GO:0060389)3.18998152
77phospholipid efflux (GO:0033700)3.17319674
78fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.16942830
79response to nitrosative stress (GO:0051409)3.16517202
80fibrinolysis (GO:0042730)3.15519414
81negative regulation of peptidyl-serine phosphorylation (GO:0033137)3.13022076
82regulation of T-helper 1 cell differentiation (GO:0045625)3.12761526
83protein-lipid complex assembly (GO:0065005)3.11372015
84nuclear pore organization (GO:0006999)3.10850869
85negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.08289881
86cholesterol homeostasis (GO:0042632)3.02916323
87positive regulation of fatty acid beta-oxidation (GO:0032000)3.00778671
88drug transmembrane transport (GO:0006855)3.00763956
89coenzyme catabolic process (GO:0009109)3.00262381
90necrotic cell death (GO:0070265)3.00118536
91serine family amino acid catabolic process (GO:0009071)3.00089302
92sterol homeostasis (GO:0055092)2.99087491
93regulation of protein polyubiquitination (GO:1902914)2.98158344
94negative regulation of lipase activity (GO:0060192)2.97663471
95UDP-N-acetylglucosamine metabolic process (GO:0006047)2.97112581
96programmed necrotic cell death (GO:0097300)2.96059375
97negative regulation of fatty acid biosynthetic process (GO:0045717)2.95334338
98signal peptide processing (GO:0006465)2.93143781
99definitive hemopoiesis (GO:0060216)2.92524815
100hepatocyte apoptotic process (GO:0097284)2.91997556
101positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.91880253
102histone mRNA catabolic process (GO:0071044)2.87900442
103drug catabolic process (GO:0042737)2.87372624
104imidazole-containing compound metabolic process (GO:0052803)2.87299727
105indolalkylamine metabolic process (GO:0006586)2.86153064
106phospholipid homeostasis (GO:0055091)2.82991460
107sphingomyelin metabolic process (GO:0006684)2.81782118
108valine metabolic process (GO:0006573)2.81192390
109heme transport (GO:0015886)2.80551703
110alpha-amino acid catabolic process (GO:1901606)2.80464038
111ethanol oxidation (GO:0006069)2.78651435
112regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.78639665
113regulation of cholesterol esterification (GO:0010872)2.78497906
114arginine metabolic process (GO:0006525)2.77399714
115complement activation, classical pathway (GO:0006958)2.74356287
116regulation of acyl-CoA biosynthetic process (GO:0050812)2.72711010
117cytolysis (GO:0019835)2.72187946
118drug metabolic process (GO:0017144)2.72089805
119positive regulation of lipoprotein lipase activity (GO:0051006)2.71213344
120positive regulation of triglyceride lipase activity (GO:0061365)2.71213344
121benzene-containing compound metabolic process (GO:0042537)2.70954640
122Rap protein signal transduction (GO:0032486)2.70775930
123mRNA modification (GO:0016556)2.70358661
124activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.70087811
125complement activation (GO:0006956)2.69934594
126amino-acid betaine metabolic process (GO:0006577)2.69926539
127regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.68890741
128ribosome assembly (GO:0042255)2.68787677
129pore complex assembly (GO:0046931)2.68516637
130hormone catabolic process (GO:0042447)2.68426931
131chondrocyte development (GO:0002063)2.68221172
132regulation of plasminogen activation (GO:0010755)2.66402029
133regulation of transforming growth factor beta2 production (GO:0032909)2.65790623
134phagocytosis, engulfment (GO:0006911)2.65262180
135regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.64916244
136regulation of T-helper 2 cell differentiation (GO:0045628)2.64682315
137negative regulation of interleukin-17 production (GO:0032700)2.63563293
138positive regulation of protein autophosphorylation (GO:0031954)2.61416691
139positive regulation of alpha-beta T cell proliferation (GO:0046641)2.58993372
140negative regulation of necroptotic process (GO:0060546)2.57711771
141negative regulation of type 2 immune response (GO:0002829)2.54623633
142positive regulation of mitotic sister chromatid separation (GO:1901970)2.52534083
143positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.52534083
144positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.52534083
145polyol biosynthetic process (GO:0046173)2.51776550
146ER to Golgi vesicle-mediated transport (GO:0006888)2.50873056
147detection of molecule of bacterial origin (GO:0032490)2.50101872
148histamine secretion (GO:0001821)2.46074763
149vesicle coating (GO:0006901)2.45831222
150regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.44025986
151neutrophil activation (GO:0042119)2.43591963
152regulation of sulfur metabolic process (GO:0042762)2.43585592
153regulation of B cell receptor signaling pathway (GO:0050855)2.43385985
154organelle membrane fusion (GO:0090174)2.40252561
155regulation of coenzyme metabolic process (GO:0051196)2.39874467
156regulation of cofactor metabolic process (GO:0051193)2.39874467
157positive regulation of coagulation (GO:0050820)2.38737403
158peroxisome fission (GO:0016559)2.38186863
159positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.37649518
160membrane budding (GO:0006900)2.37454273
161proteasome assembly (GO:0043248)2.36508614
162ether lipid metabolic process (GO:0046485)2.35495736
163regulation of memory T cell differentiation (GO:0043380)2.35050834
164cellular extravasation (GO:0045123)2.34945466
165positive regulation of blood coagulation (GO:0030194)2.34363703
166positive regulation of hemostasis (GO:1900048)2.34363703
167negative regulation of fibroblast apoptotic process (GO:2000270)2.33878819
168negative regulation of neurotransmitter secretion (GO:0046929)2.33666832
169mitotic sister chromatid cohesion (GO:0007064)2.33119501
170regulation of interleukin-17 production (GO:0032660)2.32612005
171negative regulation of protein localization to plasma membrane (GO:1903077)2.31964058
172cell adhesion mediated by integrin (GO:0033627)2.31432421
173germinal center formation (GO:0002467)2.30765091
174regulation of transforming growth factor beta1 production (GO:0032908)2.28445218
175regulation of Golgi to plasma membrane protein transport (GO:0042996)2.27988741
176regulation of fibroblast apoptotic process (GO:2000269)2.27766245
177thrombin receptor signaling pathway (GO:0070493)2.27691004
178double-strand break repair via nonhomologous end joining (GO:0006303)2.26945946
179non-recombinational repair (GO:0000726)2.26945946
180hypotonic response (GO:0006971)2.25805584
181protein localization to Golgi apparatus (GO:0034067)2.24734130
182regulation of regulatory T cell differentiation (GO:0045589)2.24355310
183phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.23636899
184cellular response to glucose starvation (GO:0042149)2.22663969
185positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.22092864
186granulocyte activation (GO:0036230)2.21676783
187AMP metabolic process (GO:0046033)2.21128278
188mitotic G2 DNA damage checkpoint (GO:0007095)2.20929931
189mesodermal cell differentiation (GO:0048333)2.20813109
190regulation of DNA endoreduplication (GO:0032875)2.19318436
191negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.18991318
192regulation of transforming growth factor beta production (GO:0071634)2.18056494
193cellular response to ethanol (GO:0071361)2.16347418
194I-kappaB phosphorylation (GO:0007252)2.16201108
195neutrophil mediated immunity (GO:0002446)2.14462587

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.98608096
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.07970045
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.09140411
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.80509915
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.49091522
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.39992772
7GATA1_22025678_ChIP-Seq_K562_Human3.93091206
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.43659261
9CLOCK_20551151_ChIP-Seq_293T_Human3.37804095
10SMAD_19615063_ChIP-ChIP_OVARY_Human3.07901404
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.83550877
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.77428826
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.61717036
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.52109409
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.43285325
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.32472900
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.99451652
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.90392381
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.88149956
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.84367075
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.80840464
22SALL4_18804426_ChIP-ChIP_XEN_Mouse1.79736248
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78638785
24SOX2_27498859_Chip-Seq_STOMACH_Mouse1.70550837
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.69659751
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68284598
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.65934087
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.64650494
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62837806
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.59035020
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57432720
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54905297
33FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.51136015
34* IRF8_27001747_Chip-Seq_BMDM_Mouse1.50791815
35GATA4_25053715_ChIP-Seq_YYC3_Human1.50614195
36NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.49317211
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.49317211
38FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48842177
39TAF15_26573619_Chip-Seq_HEK293_Human1.48785872
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.48680952
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47082178
42FUS_26573619_Chip-Seq_HEK293_Human1.46073489
43FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.45330807
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.44783324
45TFEB_21752829_ChIP-Seq_HELA_Human1.43663587
46CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42868822
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.42247605
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.41173761
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40535759
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40318385
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.35338390
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.34825710
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33495441
54SOX2_20726797_ChIP-Seq_SW620_Human1.32059629
55EWS_26573619_Chip-Seq_HEK293_Human1.29531374
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29157501
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.29061121
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27464422
59MYB_26560356_Chip-Seq_TH2_Human1.25639040
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25596786
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25018566
62FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24826610
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.24771831
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22213616
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22163925
66AR_21909140_ChIP-Seq_LNCAP_Human1.21011292
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.20350021
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20346301
69FOXA1_25552417_ChIP-Seq_VCAP_Human1.20322009
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20151156
71* SALL4_22934838_ChIP-ChIP_CD34+_Human1.19819658
72CJUN_26792858_Chip-Seq_BT549_Human1.18052556
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18042076
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15909677
75IRF8_22096565_ChIP-ChIP_GC-B_Human1.15392738
76STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.14940744
77RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14582284
78BRD4_25478319_ChIP-Seq_HGPS_Human1.13833232
79SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13080760
80SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13080760
81TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.12663217
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11878119
83SPI1_23547873_ChIP-Seq_NB4_Human1.09493668
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08112422
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06112296
86PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05803748
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05291156
88MYB_26560356_Chip-Seq_TH1_Human1.05114585
89IGF1R_20145208_ChIP-Seq_DFB_Human1.04679666
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.04358287
91* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03728813
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03205168
93HNF4A_19822575_ChIP-Seq_HepG2_Human1.02985193
94GATA6_25053715_ChIP-Seq_YYC3_Human1.02558314
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01377015
96AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01097220
97ELK1_19687146_ChIP-ChIP_HELA_Human1.00951218
98VDR_23849224_ChIP-Seq_CD4+_Human0.99057526
99POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99050448
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98915925
101SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97781799
102FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.96850082
103PU_27001747_Chip-Seq_BMDM_Mouse0.93801903
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93087027
105CMYC_18555785_Chip-Seq_ESCs_Mouse0.92998892
106NANOG_18555785_Chip-Seq_ESCs_Mouse0.92942769
107GATA2_19941826_ChIP-Seq_K562_Human0.92028979
108CDX2_22108803_ChIP-Seq_LS180_Human0.92024161
109EP300_21415370_ChIP-Seq_HL-1_Mouse0.90872915
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90108186
111TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89324892
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89284654
113SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89016268
114FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88841180
115E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.88744833
116VDR_24787735_ChIP-Seq_THP-1_Human0.88635078
117PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88304195
118ELF5_23300383_ChIP-Seq_T47D_Human0.88293856
119GATA1_19941826_ChIP-Seq_K562_Human0.87655185
120NFE2_27457419_Chip-Seq_LIVER_Mouse0.87427241
121GATA3_27048872_Chip-Seq_THYMUS_Human0.87018503
122NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86867288
123CHD1_26751641_Chip-Seq_LNCaP_Human0.86280302
124GATA3_24758297_ChIP-Seq_MCF-7_Human0.84810398
125TP63_23658742_ChIP-Seq_EP156T_Human0.83627174
126NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83222382
127SOX17_20123909_ChIP-Seq_XEN_Mouse0.82695830
128SALL1_21062744_ChIP-ChIP_HESCs_Human0.81780080
129MYB_21317192_ChIP-Seq_ERMYB_Mouse0.80998237
130EGR1_19374776_ChIP-ChIP_THP-1_Human0.79629593
131JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79486924
132RUNX_20019798_ChIP-Seq_JUKART_Human0.79252494
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79068689
134HTT_18923047_ChIP-ChIP_STHdh_Human0.78679756
135EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.78535913
136ESR2_21235772_ChIP-Seq_MCF-7_Human0.78500017
137* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78106278
138PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.77747625
139HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.77054788
140BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.74089722
141STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.73566198
142CDX2_20551321_ChIP-Seq_CACO-2_Human0.72813490
143ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.72235211
144KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.72100867
145PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71253961
146RARG_19884340_ChIP-ChIP_MEFs_Mouse0.71244091

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.15840262
2MP0005360_urolithiasis5.42151807
3MP0005365_abnormal_bile_salt4.42261925
4MP0005085_abnormal_gallbladder_physiolo4.29001154
5MP0008057_abnormal_DNA_replication3.90594250
6MP0008875_abnormal_xenobiotic_pharmacok3.18286845
7MP0003252_abnormal_bile_duct3.01005416
8MP0001666_abnormal_nutrient_absorption2.90805974
9MP0003806_abnormal_nucleotide_metabolis2.77760027
10MP0010329_abnormal_lipoprotein_level2.28893849
11MP0009697_abnormal_copulation2.27085277
12MP0002138_abnormal_hepatobiliary_system2.19315779
13MP0006054_spinal_hemorrhage2.15392897
14MP0002009_preneoplasia2.14756535
15MP0003705_abnormal_hypodermis_morpholog2.07374471
16MP0005464_abnormal_platelet_physiology2.04145096
17MP0005220_abnormal_exocrine_pancreas1.99201436
18MP0003195_calcinosis1.98961385
19MP0002396_abnormal_hematopoietic_system1.98730950
20MP0003828_pulmonary_edema1.94312031
21MP0005408_hypopigmentation1.88846512
22MP0001835_abnormal_antigen_presentation1.88720668
23MP0003300_gastrointestinal_ulcer1.88445292
24MP0008438_abnormal_cutaneous_collagen1.84844676
25MP0008004_abnormal_stomach_pH1.82625161
26MP0003868_abnormal_feces_composition1.78845464
27MP0005083_abnormal_biliary_tract1.75360563
28MP0000609_abnormal_liver_physiology1.74115246
29MP0010368_abnormal_lymphatic_system1.72550355
30MP0003950_abnormal_plasma_membrane1.69027307
31MP0003221_abnormal_cardiomyocyte_apopto1.55924110
32MP0009384_cardiac_valve_regurgitation1.55405107
33MP0005332_abnormal_amino_acid1.50302145
34MP0003091_abnormal_cell_migration1.50296460
35MP0002006_tumorigenesis1.47703835
36MP0003656_abnormal_erythrocyte_physiolo1.46871597
37MP0003303_peritoneal_inflammation1.44982199
38MP0004264_abnormal_extraembryonic_tissu1.43937313
39MP0001545_abnormal_hematopoietic_system1.41468274
40MP0005397_hematopoietic_system_phenotyp1.41468274
41MP0004084_abnormal_cardiac_muscle1.39524864
42MP0010155_abnormal_intestine_physiology1.36738847
43MP0004808_abnormal_hematopoietic_stem1.35591688
44MP0003448_altered_tumor_morphology1.35081725
45MP0003183_abnormal_peptide_metabolism1.34719023
46MP0009840_abnormal_foam_cell1.29273491
47MP0002118_abnormal_lipid_homeostasis1.26665929
48MP0010352_gastrointestinal_tract_polyps1.19650870
49MP0002332_abnormal_exercise_endurance1.19063269
50MP0008058_abnormal_DNA_repair1.17020212
51MP0004147_increased_porphyrin_level1.15804853
52MP0003191_abnormal_cellular_cholesterol1.13822016
53MP0009053_abnormal_anal_canal1.13263204
54MP0001851_eye_inflammation1.11530108
55MP0005275_abnormal_skin_tensile1.11323992
56MP0005319_abnormal_enzyme/_coenzyme1.10696938
57MP0000598_abnormal_liver_morphology1.10333254
58MP0002060_abnormal_skin_morphology1.08728558
59MP0009785_altered_susceptibility_to1.07708707
60MP0004272_abnormal_basement_membrane1.07288670
61MP0000569_abnormal_digit_pigmentation1.07202371
62MP0005023_abnormal_wound_healing1.06406914
63MP0004019_abnormal_vitamin_homeostasis1.06232910
64MP0001853_heart_inflammation1.05862217
65MP0005000_abnormal_immune_tolerance1.05790418
66MP0009643_abnormal_urine_homeostasis1.05695770
67MP0002148_abnormal_hypersensitivity_rea1.05357103
68MP0004957_abnormal_blastocyst_morpholog1.04798192
69MP0002398_abnormal_bone_marrow1.04016558
70MP0004484_altered_response_of1.02166997
71MP0005084_abnormal_gallbladder_morpholo1.01773104
72MP0000516_abnormal_urinary_system1.01712460
73MP0005367_renal/urinary_system_phenotyp1.01712460
74MP0003724_increased_susceptibility_to1.00992462
75MP0002933_joint_inflammation0.98803699
76MP0001243_abnormal_dermal_layer0.97943109
77MP0009379_abnormal_foot_pigmentation0.97865260
78MP0005503_abnormal_tendon_morphology0.97611776
79MP0002419_abnormal_innate_immunity0.96871235
80MP0005076_abnormal_cell_differentiation0.93502955
81MP0005621_abnormal_cell_physiology0.93090726
82MP0000689_abnormal_spleen_morphology0.92933609
83MP0001879_abnormal_lymphatic_vessel0.92892831
84MP0004036_abnormal_muscle_relaxation0.91341744
85MP0002405_respiratory_system_inflammati0.91323264
86MP0002452_abnormal_antigen_presenting0.90969540
87MP0002722_abnormal_immune_system0.90890374
88MP0002877_abnormal_melanocyte_morpholog0.90758350
89MP0001800_abnormal_humoral_immune0.90401307
90MP0003786_premature_aging0.89641298
91MP0002723_abnormal_immune_serum0.86157413
92MP0002896_abnormal_bone_mineralization0.84585960
93MP0002928_abnormal_bile_duct0.84456759
94MP0001944_abnormal_pancreas_morphology0.84299712
95MP0003453_abnormal_keratinocyte_physiol0.84148041
96MP0005266_abnormal_metabolism0.82920637
97MP0000013_abnormal_adipose_tissue0.82776976
98MP0001730_embryonic_growth_arrest0.82717856
99MP0009765_abnormal_xenobiotic_induced0.82618333
100MP0004215_abnormal_myocardial_fiber0.82609653
101MP0000465_gastrointestinal_hemorrhage0.82491661
102MP0001764_abnormal_homeostasis0.81941386
103MP0000858_altered_metastatic_potential0.80143941
104MP0008260_abnormal_autophagy0.79746823
105MP0008775_abnormal_heart_ventricle0.79565415
106MP0001915_intracranial_hemorrhage0.79564359
107MP0002132_abnormal_respiratory_system0.79380280
108MP0002972_abnormal_cardiac_muscle0.78859522
109MP0010234_abnormal_vibrissa_follicle0.78771755
110MP0000703_abnormal_thymus_morphology0.78670980
111MP0005166_decreased_susceptibility_to0.77609582
112MP0001216_abnormal_epidermal_layer0.75393895
113MP0000343_altered_response_to0.75260801
114MP0000350_abnormal_cell_proliferation0.75258989
115MP0005165_increased_susceptibility_to0.74791797
116MP0001697_abnormal_embryo_size0.74548062
117MP0003763_abnormal_thymus_physiology0.74239931
118MP0009763_increased_sensitivity_to0.74182848
119MP0000249_abnormal_blood_vessel0.74099773
120MP0002420_abnormal_adaptive_immunity0.73544461
121MP0002429_abnormal_blood_cell0.73077857
122MP0005164_abnormal_response_to0.72786667
123MP0005384_cellular_phenotype0.72786517
124MP0000716_abnormal_immune_system0.72547251
125MP0003795_abnormal_bone_structure0.72182362
126MP0001533_abnormal_skeleton_physiology0.71867062
127MP0003890_abnormal_embryonic-extraembry0.70961712
128MP0003186_abnormal_redox_activity0.70865622
129MP0003566_abnormal_cell_adhesion0.70830702
130MP0004947_skin_inflammation0.70349611
131MP0002295_abnormal_pulmonary_circulatio0.69596986
132MP0002078_abnormal_glucose_homeostasis0.68561858
133MP0002254_reproductive_system_inflammat0.67767634
134MP0008469_abnormal_protein_level0.67161174
135MP0000767_abnormal_smooth_muscle0.66414354
136MP0000427_abnormal_hair_cycle0.66076406
137MP0003943_abnormal_hepatobiliary_system0.65157193
138MP0001756_abnormal_urination0.62932806
139MP0003436_decreased_susceptibility_to0.62718027
140MP0002693_abnormal_pancreas_physiology0.61779174
141MP0009764_decreased_sensitivity_to0.61489654
142MP0005636_abnormal_mineral_homeostasis0.60934380
143MP0005376_homeostasis/metabolism_phenot0.59269933
144MP0002166_altered_tumor_susceptibility0.59145864
145MP0010678_abnormal_skin_adnexa0.58183787
146MP0009672_abnormal_birth_weight0.57432953
147MP0001873_stomach_inflammation0.56925334
148MP0004883_abnormal_blood_vessel0.56588324
149MP0003279_aneurysm0.55917542
150MP0005334_abnormal_fat_pad0.55160396
151MP0005584_abnormal_enzyme/coenzyme_acti0.54824011
152MP0002136_abnormal_kidney_physiology0.54369454
153MP0009642_abnormal_blood_homeostasis0.53850620
154MP0000163_abnormal_cartilage_morphology0.53429695
155MP0002098_abnormal_vibrissa_morphology0.53264268
156MP0001845_abnormal_inflammatory_respons0.52866455
157MP0001191_abnormal_skin_condition0.51471503
158MP0005647_abnormal_sex_gland0.51301871
159MP0002086_abnormal_extraembryonic_tissu0.50704025
160MP0000383_abnormal_hair_follicle0.50041248
161MP0000003_abnormal_adipose_tissue0.49927788
162MP0001661_extended_life_span0.48702962
163MP0004134_abnormal_chest_morphology0.48297299
164MP0004197_abnormal_fetal_growth/weight/0.48059023

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.74510377
2Papillary thyroid carcinoma (HP:0002895)5.13386028
3Hypobetalipoproteinemia (HP:0003563)5.02416039
4Deep venous thrombosis (HP:0002625)4.93469924
5Abnormality of the common coagulation pathway (HP:0010990)4.78132674
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.72738999
7Xanthomatosis (HP:0000991)4.65732072
8Abnormality of the intrinsic pathway (HP:0010989)4.52756890
9Prolonged partial thromboplastin time (HP:0003645)4.50996019
10Abnormality of monocarboxylic acid metabolism (HP:0010996)4.45569154
11Thyroid carcinoma (HP:0002890)4.01753006
12Fat malabsorption (HP:0002630)3.80905480
13Hypoglycemic coma (HP:0001325)3.76867828
14Conjugated hyperbilirubinemia (HP:0002908)3.74316975
15Hypolipoproteinemia (HP:0010981)3.63014410
16Complement deficiency (HP:0004431)3.54518171
17Hyperlipoproteinemia (HP:0010980)3.46954145
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.46127328
19Hypochromic microcytic anemia (HP:0004840)3.45965505
20Tetraparesis (HP:0002273)3.42313709
21Curly hair (HP:0002212)3.41795710
22Epidermoid cyst (HP:0200040)3.41464142
23Hepatoblastoma (HP:0002884)3.27492116
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.13191972
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.12900375
26Abnormal foot bone ossification (HP:0010675)3.11168673
27Abnormality of aspartate family amino acid metabolism (HP:0010899)3.06647860
28Enlarged kidneys (HP:0000105)3.06519547
29Abnormal tarsal ossification (HP:0008369)3.01702262
30Acanthocytosis (HP:0001927)3.01453081
31Joint hemorrhage (HP:0005261)3.01377894
32Hyperglycemia (HP:0003074)2.92374557
33Menstrual irregularities (HP:0000858)2.88033343
34Hyperinsulinemic hypoglycemia (HP:0000825)2.86819320
35Abnormality of methionine metabolism (HP:0010901)2.85950599
36Hypoalphalipoproteinemia (HP:0003233)2.85857095
37Short middle phalanx of the 5th finger (HP:0004220)2.85099503
38Hepatocellular carcinoma (HP:0001402)2.84973150
39Ankyloglossia (HP:0010296)2.83028444
40Hypoglycemic seizures (HP:0002173)2.76202485
41Pancreatic islet-cell hyperplasia (HP:0004510)2.75605395
42Hyperbilirubinemia (HP:0002904)2.71994161
43Myocardial infarction (HP:0001658)2.71601119
44Cupped ribs (HP:0000887)2.68268045
45Spondylolisthesis (HP:0003302)2.67245341
46Abnormality of complement system (HP:0005339)2.66324229
47Steatorrhea (HP:0002570)2.65867964
48Abnormality of endocrine pancreas physiology (HP:0012093)2.62434716
49Abnormality of the pancreatic islet cells (HP:0006476)2.62434716
50Autoimmune hemolytic anemia (HP:0001890)2.62155773
51Abnormal pancreas size (HP:0012094)2.61307748
52Ketosis (HP:0001946)2.61071703
53Testicular neoplasm (HP:0010788)2.57824803
54Termporal pattern (HP:0011008)2.55353048
55Insidious onset (HP:0003587)2.55353048
56Thickened calvaria (HP:0002684)2.54305910
57Skin nodule (HP:0200036)2.53308200
58Cutaneous melanoma (HP:0012056)2.52954660
59Hyperammonemia (HP:0001987)2.49102389
60Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.47693430
61Abnormality of T cell number (HP:0011839)2.46858383
62Fatigue (HP:0012378)2.46671510
63Epiphyseal dysplasia (HP:0002656)2.43718585
64Vitreoretinal degeneration (HP:0000655)2.43330336
65Prolonged bleeding time (HP:0003010)2.39264976
66Acute myeloid leukemia (HP:0004808)2.36476094
67Increased mean platelet volume (HP:0011877)2.35550630
68Palpitations (HP:0001962)2.33781011
69Abnormality of the ischium (HP:0003174)2.31349928
70Thoracolumbar scoliosis (HP:0002944)2.30692058
71Ketoacidosis (HP:0001993)2.27265026
72Abnormality of oral frenula (HP:0000190)2.25126605
73Spinal cord lesions (HP:0100561)2.24560573
74Syringomyelia (HP:0003396)2.24560573
75T lymphocytopenia (HP:0005403)2.24468303
76Hypoplastic labia majora (HP:0000059)2.24201157
77Cavernous hemangioma (HP:0001048)2.20778625
78Poikilocytosis (HP:0004447)2.19203065
79Hypoplastic ischia (HP:0003175)2.18055661
80Papilledema (HP:0001085)2.16661013
81Thrombophlebitis (HP:0004418)2.15846221
82Hypercholesterolemia (HP:0003124)2.14034880
83Disinhibition (HP:0000734)2.13969344
84Biliary tract neoplasm (HP:0100574)2.12229875
85Menorrhagia (HP:0000132)2.11816106
86Deep philtrum (HP:0002002)2.11569201
87Unilateral renal agenesis (HP:0000122)2.10639380
88Abnormal platelet volume (HP:0011876)2.08788888
89Neoplasm of the tracheobronchial system (HP:0100552)2.08578140
90Abnormality of fatty-acid metabolism (HP:0004359)2.08235424
91Esophageal varix (HP:0002040)2.07595596
92Neoplasm of the small intestine (HP:0100833)2.06849565
93Epistaxis (HP:0000421)2.06803683
94Freckling (HP:0001480)2.04364659
95Abnormality of purine metabolism (HP:0004352)2.04097539
96Neoplasm of the thyroid gland (HP:0100031)2.02682923
97Subaortic stenosis (HP:0001682)2.01947640
98Abnormality of the left ventricular outflow tract (HP:0011103)2.01947640
99Osteolytic defects of the hand bones (HP:0009699)2.01922288
100Osteolytic defects of the phalanges of the hand (HP:0009771)2.01922288
101Hyperglycinemia (HP:0002154)2.01922093
102Absent frontal sinuses (HP:0002688)2.00906321
103Abnormal cartilage morphology (HP:0002763)2.00023003
104Abnormal delayed hypersensitivity skin test (HP:0002963)1.99100292
105Arterial tortuosity (HP:0005116)1.99003907
106Protuberant abdomen (HP:0001538)1.98760512
107Beaking of vertebral bodies (HP:0004568)1.97428953
108Pancreatitis (HP:0001733)1.97399293
109Gingival bleeding (HP:0000225)1.96736718
110Premature rupture of membranes (HP:0001788)1.96603702
111Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.96584385
112Pheochromocytoma (HP:0002666)1.96566560
113Transitional cell carcinoma of the bladder (HP:0006740)1.96392617
114Abnormality of the labia majora (HP:0012881)1.94566561
115Alveolar cell carcinoma (HP:0006519)1.94018832
116Exocrine pancreatic insufficiency (HP:0001738)1.93797116
117Pulmonary embolism (HP:0002204)1.93657950
118Central scotoma (HP:0000603)1.93354949
119Neonatal respiratory distress (HP:0002643)1.93346640
120Mitral stenosis (HP:0001718)1.93241660
121Symptomatic seizures (HP:0011145)1.93045316
122Abnormality of glycine metabolism (HP:0010895)1.92569078
123Abnormality of serine family amino acid metabolism (HP:0010894)1.92569078
124Spontaneous abortion (HP:0005268)1.92473886
125Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.90771140
126Abnormality of proline metabolism (HP:0010907)1.90539339
127Hydroxyprolinuria (HP:0003080)1.90539339
128Acute hepatic failure (HP:0006554)1.89914544
129Bladder carcinoma (HP:0002862)1.89759696
130Bladder neoplasm (HP:0009725)1.89759696
131Dyschromatopsia (HP:0007641)1.89305995
132Submucous cleft hard palate (HP:0000176)1.88873319
133Abnormal gallbladder morphology (HP:0012437)1.88838582
134Neoplasm of the liver (HP:0002896)1.87879484
135Polycythemia (HP:0001901)1.87755968
136Relative macrocephaly (HP:0004482)1.87697184
137Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.86274079
138Cardiovascular calcification (HP:0011915)1.86021288
139Abnormality of nucleobase metabolism (HP:0010932)1.85157426
140Aortic aneurysm (HP:0004942)1.84655609
141Gonadal dysgenesis (HP:0000133)1.81893027
142Cystic hygroma (HP:0000476)1.81802877
143Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.81633707
144Gout (HP:0001997)1.81539374
145Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80856426
146Abnormality of alanine metabolism (HP:0010916)1.80856426
147Hyperalaninemia (HP:0003348)1.80856426
148Gonadotropin excess (HP:0000837)1.80053927
149Barrel-shaped chest (HP:0001552)1.78862878
150Hyperglycinuria (HP:0003108)1.78796470
151Vascular calcification (HP:0004934)1.78705478
152Eczematoid dermatitis (HP:0000976)1.78497215
153Vascular tortuosity (HP:0004948)1.77402580
154Neoplasm of the rectum (HP:0100743)1.76533010
155Abnormality of T cell physiology (HP:0011840)1.75849118
156Osteomyelitis (HP:0002754)1.75693636
157Decreased skull ossification (HP:0004331)1.75607256
158Aortic dissection (HP:0002647)1.75599403
159Right ventricular cardiomyopathy (HP:0011663)1.75521804
160Joint swelling (HP:0001386)1.74645608
161Metaphyseal cupping (HP:0003021)1.74628205
162Abnormality of the vasculature of the conjunctiva (HP:0008054)1.74115969
163Recurrent viral infections (HP:0004429)1.73045383
164Conjunctival telangiectasia (HP:0000524)1.72683287
165Generalized aminoaciduria (HP:0002909)1.72380897
166Subacute progressive viral hepatitis (HP:0006572)1.71524991
167Hematochezia (HP:0002573)1.70635481
168Stomatitis (HP:0010280)1.70383550
169Abdominal distention (HP:0003270)1.69817115
170Metabolic acidosis (HP:0001942)1.69276271
171Malnutrition (HP:0004395)1.69224926
172Spontaneous hematomas (HP:0007420)1.69143945
173Nonimmune hydrops fetalis (HP:0001790)1.68290179
174Conjunctival hamartoma (HP:0100780)1.65306600
175Metaphyseal dysplasia (HP:0100255)1.64852792
176Abnormal biliary tract morphology (HP:0012440)1.64631181
177Diastasis recti (HP:0001540)1.64603238
178Mucosal telangiectasiae (HP:0100579)1.63282845
179Irregular vertebral endplates (HP:0003301)1.62584804
180Delayed closure of the anterior fontanelle (HP:0001476)1.62271178
181Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.62258930
182Small epiphyses (HP:0010585)1.62245529
183Ectopia lentis (HP:0001083)1.61641695

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.72178071
2BMPR22.95854875
3ERN12.86727239
4TAOK32.46947949
5FGFR42.46842532
6FGFR22.43359858
7TRIM282.20372447
8SIK32.10603610
9PDK22.10378227
10LATS11.99707167
11AKT31.98246962
12EPHB11.97605589
13MAP3K31.94281521
14NUAK11.91026622
15PIK3CG1.90617955
16BRSK21.89929654
17INSRR1.87506667
18CDK121.85103498
19EPHA31.83213138
20STK101.82514772
21ACVR1B1.69999568
22EIF2AK31.66279683
23SRPK11.65100466
24TYK21.64504253
25TNIK1.64289825
26RIPK41.60013794
27PTK61.56822846
28BRD41.56534779
29MAP3K141.55136209
30TGFBR21.54984956
31MET1.52988426
32BCR1.49812553
33STK31.49284325
34ERBB41.46976636
35ITK1.46809970
36PDGFRA1.39564250
37SIK11.38378419
38MAP3K121.37478346
39FLT31.35945228
40MAP3K101.35763564
41BCKDK1.34001957
42STK241.31180374
43FGFR31.29115304
44EPHA21.27658471
45BMPR1B1.22488955
46MAPK151.18713256
47MYLK1.18233323
48SCYL21.16826144
49KDR1.16606021
50STK38L1.16440622
51KSR11.13551663
52MST41.11137167
53GSK3A1.09371643
54YES11.08052331
55MAP3K51.06909104
56TTK1.05281604
57CHUK1.01279994
58MAP3K61.01169982
59PDGFRB0.97975858
60STK390.97525397
61ERBB30.92868046
62MELK0.92555676
63VRK10.92036807
64PTK20.91686726
65PLK30.88443987
66CSK0.87363507
67NEK10.85938891
68PASK0.85315524
69CSNK1A1L0.84840516
70DYRK30.84599952
71CSNK1G10.84439231
72DYRK1B0.83474444
73RPS6KA50.82908354
74HIPK20.82134667
75JAK10.81513272
76LMTK20.81419405
77CDC70.81350530
78FER0.80631461
79BRAF0.80134916
80TBK10.79137662
81TRPM70.78845859
82WNK40.77902368
83CSF1R0.77821079
84NEK90.77089331
85EIF2AK10.74849773
86PAK30.74318481
87RPS6KA40.73898774
88PLK20.73895299
89MAP3K20.72110842
90MAP2K30.71260167
91NLK0.71211057
92JAK20.70183487
93MARK30.69834910
94CAMKK20.68408032
95CLK10.68072372
96MST1R0.67895878
97MKNK10.67467183
98FGFR10.66551599
99TEC0.66280137
100GRK60.65584920
101PAK20.64773696
102PKN10.64762158
103PRKAA20.64157650
104PRKCQ0.60615241
105IRAK30.60243997
106MTOR0.59826197
107CDK60.59821977
108DDR20.59648882
109STK40.59368914
110JAK30.58122278
111MAPK70.57427553
112IKBKB0.55993530
113RAF10.55880850
114IKBKE0.54649888
115TSSK60.53298866
116PBK0.53268890
117CSNK1G30.52992259
118OBSCN0.52485976
119EIF2AK20.52360743
120CDK90.50337312
121NEK60.49805902
122MKNK20.49534595
123SGK20.49351380
124MAPKAPK20.48003601
125SGK30.47206614
126IRAK10.46321435
127ZAK0.45838457
128TXK0.44736661
129HCK0.44396731
130BRSK10.43906962
131ALK0.42688360
132MAP3K40.41079849
133PIK3CA0.40686152
134RIPK10.40652125
135TGFBR10.40297735
136RET0.39442942
137MAPK40.39241033
138DMPK0.38794411
139EGFR0.38745103
140PRKG20.38707209
141MAP2K20.38223664
142PIM10.38019561
143IRAK40.37959930
144ABL10.37137686
145WEE10.37096544
146ATM0.34965187
147CCNB10.34758737
148KSR20.33660985
149AKT20.30578068
150GRK70.29564793
151PRKCE0.29372068

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.90765663
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.00196990
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.99040628
4Complement and coagulation cascades_Homo sapiens_hsa046102.70762780
5Non-homologous end-joining_Homo sapiens_hsa034502.54454310
6Sulfur metabolism_Homo sapiens_hsa009202.47984934
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.46387106
8Tryptophan metabolism_Homo sapiens_hsa003802.46015819
9Arginine biosynthesis_Homo sapiens_hsa002202.32771590
10Caffeine metabolism_Homo sapiens_hsa002322.23302828
11Fatty acid degradation_Homo sapiens_hsa000712.16429614
12Nitrogen metabolism_Homo sapiens_hsa009102.08236416
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.07919101
14Sphingolipid metabolism_Homo sapiens_hsa006002.02045016
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.01679064
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.01488072
17Histidine metabolism_Homo sapiens_hsa003401.97806101
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.97209025
19Selenocompound metabolism_Homo sapiens_hsa004501.92693577
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92414860
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.91949100
22Fat digestion and absorption_Homo sapiens_hsa049751.85549740
23Protein export_Homo sapiens_hsa030601.82731889
24Shigellosis_Homo sapiens_hsa051311.67713316
25Butanoate metabolism_Homo sapiens_hsa006501.66816718
26Starch and sucrose metabolism_Homo sapiens_hsa005001.66746718
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66491216
28Peroxisome_Homo sapiens_hsa041461.60544844
29Staphylococcus aureus infection_Homo sapiens_hsa051501.60312359
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59372152
31Chemical carcinogenesis_Homo sapiens_hsa052041.57551702
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56907332
33Pancreatic cancer_Homo sapiens_hsa052121.56418690
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.55592314
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.54416757
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.51750373
37Thyroid cancer_Homo sapiens_hsa052161.50258178
38PPAR signaling pathway_Homo sapiens_hsa033201.49525452
39Propanoate metabolism_Homo sapiens_hsa006401.48509171
40Folate biosynthesis_Homo sapiens_hsa007901.46017340
41TNF signaling pathway_Homo sapiens_hsa046681.45185117
42Measles_Homo sapiens_hsa051621.43807889
43Vitamin digestion and absorption_Homo sapiens_hsa049771.43789789
44Platelet activation_Homo sapiens_hsa046111.41096733
45Inositol phosphate metabolism_Homo sapiens_hsa005621.39671048
46Retinol metabolism_Homo sapiens_hsa008301.38286821
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38029955
48Basal transcription factors_Homo sapiens_hsa030221.35193429
49ABC transporters_Homo sapiens_hsa020101.34902028
50Fatty acid metabolism_Homo sapiens_hsa012121.31535796
51Renal cell carcinoma_Homo sapiens_hsa052111.29777783
52p53 signaling pathway_Homo sapiens_hsa041151.28946120
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28141683
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.28114508
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25353078
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22580001
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20054784
58Salmonella infection_Homo sapiens_hsa051321.19426691
59Non-small cell lung cancer_Homo sapiens_hsa052231.17823674
60beta-Alanine metabolism_Homo sapiens_hsa004101.16949478
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15633363
62Fatty acid elongation_Homo sapiens_hsa000621.14602619
63Steroid biosynthesis_Homo sapiens_hsa001001.13227547
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12889711
65FoxO signaling pathway_Homo sapiens_hsa040681.12497444
66Jak-STAT signaling pathway_Homo sapiens_hsa046301.11856735
67Hematopoietic cell lineage_Homo sapiens_hsa046401.11118658
68Lysine degradation_Homo sapiens_hsa003101.10218163
69Hepatitis B_Homo sapiens_hsa051611.09836171
70B cell receptor signaling pathway_Homo sapiens_hsa046621.09297932
71Phenylalanine metabolism_Homo sapiens_hsa003601.08929097
72Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07185210
73Influenza A_Homo sapiens_hsa051641.06949645
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06949613
75Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06884726
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06004204
77Tyrosine metabolism_Homo sapiens_hsa003501.05485664
78Sphingolipid signaling pathway_Homo sapiens_hsa040711.04708246
79Endometrial cancer_Homo sapiens_hsa052131.00152968
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00136845
81Bile secretion_Homo sapiens_hsa049760.99438685
82Herpes simplex infection_Homo sapiens_hsa051680.96944127
83Chronic myeloid leukemia_Homo sapiens_hsa052200.96872620
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95944214
85Osteoclast differentiation_Homo sapiens_hsa043800.94778425
86Chemokine signaling pathway_Homo sapiens_hsa040620.94724483
87Arginine and proline metabolism_Homo sapiens_hsa003300.94231740
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91884129
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91776992
90Toxoplasmosis_Homo sapiens_hsa051450.90609300
91African trypanosomiasis_Homo sapiens_hsa051430.90496065
92Pyruvate metabolism_Homo sapiens_hsa006200.90263874
93Acute myeloid leukemia_Homo sapiens_hsa052210.87141654
94mTOR signaling pathway_Homo sapiens_hsa041500.85539744
95Apoptosis_Homo sapiens_hsa042100.82099232
96Glutathione metabolism_Homo sapiens_hsa004800.82086198
97Proteoglycans in cancer_Homo sapiens_hsa052050.80100615
98Colorectal cancer_Homo sapiens_hsa052100.79188644
99T cell receptor signaling pathway_Homo sapiens_hsa046600.78532398
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.77396781
101Leishmaniasis_Homo sapiens_hsa051400.77286413
102Protein digestion and absorption_Homo sapiens_hsa049740.75933558
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74096322
104Pertussis_Homo sapiens_hsa051330.72073346
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70826536
106Prolactin signaling pathway_Homo sapiens_hsa049170.70818479
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69396641
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.68343859
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67791729
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67768344
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.67732582
112Renin-angiotensin system_Homo sapiens_hsa046140.67196976
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66893293
114Tuberculosis_Homo sapiens_hsa051520.66042375
115Dorso-ventral axis formation_Homo sapiens_hsa043200.65415223
116HIF-1 signaling pathway_Homo sapiens_hsa040660.64887673
117ECM-receptor interaction_Homo sapiens_hsa045120.64830266
118Nucleotide excision repair_Homo sapiens_hsa034200.63635909
119Systemic lupus erythematosus_Homo sapiens_hsa053220.62034758
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61533536
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58778954
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58316067
123Insulin resistance_Homo sapiens_hsa049310.57678259
124RNA degradation_Homo sapiens_hsa030180.57517474
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57201437
126One carbon pool by folate_Homo sapiens_hsa006700.55423789
127Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54058373
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.49455633
129N-Glycan biosynthesis_Homo sapiens_hsa005100.49329892
130Glycerolipid metabolism_Homo sapiens_hsa005610.49091763
131Galactose metabolism_Homo sapiens_hsa000520.47887172
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47108591
133Sulfur relay system_Homo sapiens_hsa041220.46336922
134Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46054931
135Vitamin B6 metabolism_Homo sapiens_hsa007500.45833629
136Melanoma_Homo sapiens_hsa052180.45520746
137Biosynthesis of amino acids_Homo sapiens_hsa012300.44897466
138Carbon metabolism_Homo sapiens_hsa012000.41780848
139Prostate cancer_Homo sapiens_hsa052150.40616923
140Adherens junction_Homo sapiens_hsa045200.39987987
141Small cell lung cancer_Homo sapiens_hsa052220.39411127
142Linoleic acid metabolism_Homo sapiens_hsa005910.37194230
143Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34725811
144alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34359025
145Prion diseases_Homo sapiens_hsa050200.31474144
1462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30764235
147Focal adhesion_Homo sapiens_hsa045100.29887570
148Legionellosis_Homo sapiens_hsa051340.29385515
149Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27228486
150Metabolic pathways_Homo sapiens_hsa011000.25516285
151TGF-beta signaling pathway_Homo sapiens_hsa043500.24559904
152Amoebiasis_Homo sapiens_hsa051460.23428328
153Malaria_Homo sapiens_hsa051440.22649576
154Viral carcinogenesis_Homo sapiens_hsa052030.22007162
155Antigen processing and presentation_Homo sapiens_hsa046120.20988175
156Arachidonic acid metabolism_Homo sapiens_hsa005900.20703960
157PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19911950
158Leukocyte transendothelial migration_Homo sapiens_hsa046700.19517066
159NF-kappa B signaling pathway_Homo sapiens_hsa040640.18313660
160SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17775983
161Thyroid hormone synthesis_Homo sapiens_hsa049180.17575552
162Circadian rhythm_Homo sapiens_hsa047100.17021936
163Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16714351
164Hepatitis C_Homo sapiens_hsa051600.14464453
165Bladder cancer_Homo sapiens_hsa052190.13978498
166AMPK signaling pathway_Homo sapiens_hsa041520.11972679
167MicroRNAs in cancer_Homo sapiens_hsa052060.11350060

Most similar genes based on co-expression Upload to Enrichr

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