LYSMD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1substrate-independent telencephalic tangential migration (GO:0021826)6.04684877
2substrate-independent telencephalic tangential interneuron migration (GO:0021843)6.04684877
3behavioral response to nicotine (GO:0035095)5.09108415
4synaptic vesicle exocytosis (GO:0016079)4.85189302
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.71326278
6neuron cell-cell adhesion (GO:0007158)4.69516867
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.48989301
8vocalization behavior (GO:0071625)4.46756055
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.04502594
10glutamate secretion (GO:0014047)4.04254681
11regulation of synaptic vesicle exocytosis (GO:2000300)4.01282710
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.89152227
13regulation of glutamate receptor signaling pathway (GO:1900449)3.87432956
14neuronal action potential propagation (GO:0019227)3.83578294
15protein localization to synapse (GO:0035418)3.79740130
16secondary heart field specification (GO:0003139)3.75827658
17heart field specification (GO:0003128)3.75827658
18neurofilament cytoskeleton organization (GO:0060052)3.73837582
19neurotransmitter secretion (GO:0007269)3.73263244
20positive regulation of protein homodimerization activity (GO:0090073)3.73138160
21locomotory exploration behavior (GO:0035641)3.72671923
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.71292309
23gamma-aminobutyric acid signaling pathway (GO:0007214)3.70931232
24dendritic spine morphogenesis (GO:0060997)3.66890574
25regulation of synaptic vesicle transport (GO:1902803)3.65244791
26dentate gyrus development (GO:0021542)3.60980344
27segment specification (GO:0007379)3.59836096
28synaptic vesicle maturation (GO:0016188)3.59047749
29neuron-neuron synaptic transmission (GO:0007270)3.51257679
30neuron recognition (GO:0008038)3.48081980
31skeletal muscle organ development (GO:0060538)3.40498857
32epithelial cell differentiation involved in kidney development (GO:0035850)3.37725873
33mitochondrial genome maintenance (GO:0000002)3.37061699
34behavioral response to cocaine (GO:0048148)3.37034460
35synaptic transmission, cholinergic (GO:0007271)3.36657784
36response to histamine (GO:0034776)3.34476915
37ionotropic glutamate receptor signaling pathway (GO:0035235)3.28776434
38positive regulation of mitochondrial fission (GO:0090141)3.27761610
39positive regulation of synapse maturation (GO:0090129)3.26802483
40establishment of mitochondrion localization (GO:0051654)3.26089240
41arginine catabolic process (GO:0006527)3.25712103
42diaphragm development (GO:0060539)3.25676897
43synaptic vesicle docking involved in exocytosis (GO:0016081)3.25342416
44glutamate receptor signaling pathway (GO:0007215)3.24576816
45positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.22946640
46transmission of nerve impulse (GO:0019226)3.22041957
47ATP hydrolysis coupled proton transport (GO:0015991)3.20917153
48energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.20917153
49mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.19527649
50synaptic transmission, glutamatergic (GO:0035249)3.18724778
51negative regulation of neurotransmitter transport (GO:0051589)3.18413503
52regulation of neurotransmitter uptake (GO:0051580)3.18012643
53respiratory chain complex IV assembly (GO:0008535)3.17799073
54ubiquinone biosynthetic process (GO:0006744)3.17414391
55negative regulation of synaptic transmission, GABAergic (GO:0032229)3.16892780
56neuromuscular synaptic transmission (GO:0007274)3.15744114
57membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.15645967
58positive regulation of potassium ion transmembrane transport (GO:1901381)3.15265944
59exploration behavior (GO:0035640)3.14290688
60presynaptic membrane assembly (GO:0097105)3.12451571
61ubiquinone metabolic process (GO:0006743)3.11938865
62regulation of synapse structural plasticity (GO:0051823)3.11788450
63neurotransmitter transport (GO:0006836)3.11506262
64positive regulation of cell size (GO:0045793)3.09505149
65gamma-aminobutyric acid transport (GO:0015812)3.08015065
66layer formation in cerebral cortex (GO:0021819)3.06382465
67synaptic transmission, dopaminergic (GO:0001963)3.05511416
68mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.03965339
69neurotransmitter-gated ion channel clustering (GO:0072578)3.03593678
70regulation of vesicle fusion (GO:0031338)3.03090624
71regulation of neurotransmitter levels (GO:0001505)3.01915637
72neuronal action potential (GO:0019228)3.01168934
73regulation of membrane repolarization (GO:0060306)3.00989765
74regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.00857075
75regulation of neuronal synaptic plasticity (GO:0048168)2.99089784
76positive regulation of sodium ion transmembrane transport (GO:1902307)2.98080301
77regulation of long-term neuronal synaptic plasticity (GO:0048169)2.95840015
78activation of protein kinase A activity (GO:0034199)2.95815448
79striatum development (GO:0021756)2.95427673
80neuromuscular process controlling posture (GO:0050884)2.94167459
81long-term synaptic potentiation (GO:0060291)2.93699050
82synaptic vesicle endocytosis (GO:0048488)2.93505508
83adult walking behavior (GO:0007628)2.92971190
84mating behavior (GO:0007617)2.91453898
85cell migration in hindbrain (GO:0021535)2.91372764
86specification of organ identity (GO:0010092)2.91299872
87mitochondrial respiratory chain complex I assembly (GO:0032981)2.91174461
88NADH dehydrogenase complex assembly (GO:0010257)2.91174461
89mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.91174461
90regulation of nuclear cell cycle DNA replication (GO:0033262)2.90693120
91axonal fasciculation (GO:0007413)2.90605343
92ATP synthesis coupled proton transport (GO:0015986)2.90289773
93energy coupled proton transport, down electrochemical gradient (GO:0015985)2.90289773
94presynaptic membrane organization (GO:0097090)2.88405180
95regulation of excitatory postsynaptic membrane potential (GO:0060079)2.84734716
96regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.83722163
97regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.83722163
98detection of calcium ion (GO:0005513)2.80366660
99glycerophospholipid catabolic process (GO:0046475)2.80084930
100response to cocaine (GO:0042220)2.78871186
101ncRNA catabolic process (GO:0034661)2.78625127
102regulation of postsynaptic membrane potential (GO:0060078)2.77718613
103response to dietary excess (GO:0002021)2.77489387
104neuronal ion channel clustering (GO:0045161)2.77023664
105response to amphetamine (GO:0001975)2.75460768
106positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.74434936
107long-term memory (GO:0007616)2.74144919
108N-glycan processing (GO:0006491)2.73991090
109respiratory electron transport chain (GO:0022904)2.71550052
110multicellular organismal signaling (GO:0035637)2.71539471
111regulation of glutamate secretion (GO:0014048)2.71359229
112pyrimidine nucleobase catabolic process (GO:0006208)2.71335800
113cardiac ventricle formation (GO:0003211)2.71242414
114innervation (GO:0060384)2.71214593
115negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.70852340
116regulation of protein kinase A signaling (GO:0010738)2.70582616
117transferrin transport (GO:0033572)2.70263266
118membrane depolarization during action potential (GO:0086010)2.69910273
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.69404709
120regulation of synaptic plasticity (GO:0048167)2.68190640
121regulation of synaptic transmission, glutamatergic (GO:0051966)2.68080121
122chaperone-mediated protein transport (GO:0072321)2.67658798
123inner mitochondrial membrane organization (GO:0007007)2.67621232
124proline transport (GO:0015824)2.67230310
125regulation of neurotransmitter secretion (GO:0046928)2.67138205
126detection of temperature stimulus (GO:0016048)2.66925652
127regulation of voltage-gated calcium channel activity (GO:1901385)2.66587435
128regulation of catecholamine metabolic process (GO:0042069)2.66490462
129regulation of dopamine metabolic process (GO:0042053)2.66490462
130positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.66486476
131arginine metabolic process (GO:0006525)2.65568947
132electron transport chain (GO:0022900)2.65115576
133regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.65084249
134platelet dense granule organization (GO:0060155)2.64066514
135regulation of dendritic spine morphogenesis (GO:0061001)2.63414277
136cerebellar Purkinje cell differentiation (GO:0021702)2.63380442
137protein complex biogenesis (GO:0070271)2.62637512
138positive regulation of synapse assembly (GO:0051965)2.62487835
139regulation of norepinephrine secretion (GO:0014061)2.62335607
140positive regulation of membrane potential (GO:0045838)2.62076462
141negative regulation of microtubule polymerization (GO:0031115)2.62056210
142postsynaptic membrane organization (GO:0001941)2.61986529
143cytochrome complex assembly (GO:0017004)2.61545853
144neurotransmitter biosynthetic process (GO:0042136)2.61361711
145regulation of neurotransmitter transport (GO:0051588)2.61349145
146response to auditory stimulus (GO:0010996)2.61142689
147establishment of synaptic vesicle localization (GO:0097480)2.60970375
148synaptic vesicle transport (GO:0048489)2.60970375
149cerebellar granule cell differentiation (GO:0021707)2.60432578
150nucleobase catabolic process (GO:0046113)2.60076186
151mitochondrion transport along microtubule (GO:0047497)2.60052263
152establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.60052263
153synapse assembly (GO:0007416)2.59849964
154prepulse inhibition (GO:0060134)2.57815105
155positive regulation of neurotransmitter transport (GO:0051590)2.57177450
156quinone biosynthetic process (GO:1901663)2.56703778
157pyrimidine nucleotide catabolic process (GO:0006244)2.55901329
158regulation of sarcomere organization (GO:0060297)2.55213753
159negative regulation of potassium ion transport (GO:0043267)2.54200432
160epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.53890451
161mitochondrion morphogenesis (GO:0070584)2.53371236
162activation of MAPKKK activity (GO:0000185)2.52835562
163regulation of synaptic transmission, dopaminergic (GO:0032225)2.51197444
164urinary tract smooth muscle contraction (GO:0014848)2.50452935
165negative regulation of amino acid transport (GO:0051956)2.49954618
166regulation of dopamine secretion (GO:0014059)2.49773555
167cardiac chamber formation (GO:0003207)2.48208854

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.63265688
2GBX2_23144817_ChIP-Seq_PC3_Human3.45824647
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.84685570
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81536506
5TAF15_26573619_Chip-Seq_HEK293_Human2.66849031
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.65205650
7REST_21632747_ChIP-Seq_MESCs_Mouse2.53689215
8RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.40393115
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.38506415
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.34096569
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.34096569
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33378546
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32277024
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30577602
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28983602
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23776396
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.22585402
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.21657385
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.20618347
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.06914925
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06274703
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.03371653
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.01857497
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98711754
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98562406
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.96044413
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80098891
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.77518460
29DROSHA_22980978_ChIP-Seq_HELA_Human1.74517265
30SMAD4_21799915_ChIP-Seq_A2780_Human1.73277369
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72095162
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69359909
33ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.67065482
34ZNF274_21170338_ChIP-Seq_K562_Hela1.66381159
35IGF1R_20145208_ChIP-Seq_DFB_Human1.64783871
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64767275
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59624949
38P300_19829295_ChIP-Seq_ESCs_Human1.57067542
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.55931251
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55142485
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55043017
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54541675
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54299596
44AR_21572438_ChIP-Seq_LNCaP_Human1.53486397
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51754473
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51194715
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48332220
48VDR_22108803_ChIP-Seq_LS180_Human1.41363826
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.40404012
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39398519
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.37922086
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37844056
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37244595
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37011304
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.36349476
56ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34132063
57SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.33345951
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.33089462
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32579087
60AR_25329375_ChIP-Seq_VCAP_Human1.29805006
61* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28064461
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27669677
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.27120595
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26877030
65TP53_20018659_ChIP-ChIP_R1E_Mouse1.26664136
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26279836
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25421809
68RNF2_27304074_Chip-Seq_NSC_Mouse1.24507668
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24084699
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23383074
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22108128
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.21310891
73IRF1_19129219_ChIP-ChIP_H3396_Human1.20608165
74* BCAT_22108803_ChIP-Seq_LS180_Human1.18868502
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18002015
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17577584
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17553413
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16401674
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15456891
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.14881377
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14539286
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13716991
83ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13144375
84STAT3_23295773_ChIP-Seq_U87_Human1.12974956
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12300068
86ER_23166858_ChIP-Seq_MCF-7_Human1.10705612
87RUNX2_22187159_ChIP-Seq_PCA_Human1.09923665
88GATA1_26923725_Chip-Seq_HPCs_Mouse1.09572909
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09174290
90MYC_18940864_ChIP-ChIP_HL60_Human1.08319029
91FUS_26573619_Chip-Seq_HEK293_Human1.06731173
92KDM2B_26808549_Chip-Seq_K562_Human1.05901261
93RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03469714
94CTCF_27219007_Chip-Seq_Bcells_Human1.03221286
95AHR_22903824_ChIP-Seq_MCF-7_Human1.02510481
96JUN_21703547_ChIP-Seq_K562_Human1.02407589
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02045968
98TCF4_23295773_ChIP-Seq_U87_Human1.00047391
99AR_19668381_ChIP-Seq_PC3_Human0.99882941
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99012991
101ARNT_22903824_ChIP-Seq_MCF-7_Human0.98470332
102TAF2_19829295_ChIP-Seq_ESCs_Human0.98319338
103CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98218326
104FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97362426
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96439351
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96439351
107RING1B_27294783_Chip-Seq_ESCs_Mouse0.96115349
108EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95188129
109ESR1_20079471_ChIP-ChIP_T-47D_Human0.94673705
110KDM2B_26808549_Chip-Seq_REH_Human0.94043123
111EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93815585
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93510158
113DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92994942
114SMAD4_21741376_ChIP-Seq_HESCs_Human0.92486167
115SMAD3_21741376_ChIP-Seq_ESCs_Human0.91378887
116WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91321466
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90972489
118NANOG_18555785_Chip-Seq_ESCs_Mouse0.90815268
119EP300_21415370_ChIP-Seq_HL-1_Mouse0.90702392
120ELK4_26923725_Chip-Seq_MESODERM_Mouse0.89443971
121* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89219109
122FLI1_21867929_ChIP-Seq_TH2_Mouse0.88793199
123CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88728043
124IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88139590
125CBP_20019798_ChIP-Seq_JUKART_Human0.88139590
126RING1B_27294783_Chip-Seq_NPCs_Mouse0.87998911
127NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87887095
128OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86166444
129GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83812435
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83363245
131MYC_19829295_ChIP-Seq_ESCs_Human0.82522152
132SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81998919
133* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81486420
134NANOG_20526341_ChIP-Seq_ESCs_Human0.81316131
135KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.79598004
136OCT4_19829295_ChIP-Seq_ESCs_Human0.79023697
137P68_20966046_ChIP-Seq_HELA_Human0.78826630
138GATA3_21867929_ChIP-Seq_TH1_Mouse0.78806204
139EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78113031
140POU5F1_16153702_ChIP-ChIP_HESCs_Human0.77960877
141HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.77583726
142SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.76873094

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.08229057
2MP0003880_abnormal_central_pattern5.04512165
3MP0000566_synostosis3.82149727
4MP0003635_abnormal_synaptic_transmissio3.49408654
5MP0004270_analgesia3.45054089
6MP0009046_muscle_twitch3.09910656
7MP0009745_abnormal_behavioral_response2.96915757
8MP0001968_abnormal_touch/_nociception2.96784120
9MP0002063_abnormal_learning/memory/cond2.86263367
10MP0002064_seizures2.81876732
11MP0002837_dystrophic_cardiac_calcinosis2.77632077
12MP0002736_abnormal_nociception_after2.68404178
13MP0002822_catalepsy2.64427308
14MP0006276_abnormal_autonomic_nervous2.62817621
15MP0002572_abnormal_emotion/affect_behav2.54286403
16MP0002734_abnormal_mechanical_nocicepti2.54064889
17MP0001529_abnormal_vocalization2.42372586
18MP0002272_abnormal_nervous_system2.32299873
19MP0002735_abnormal_chemical_nociception2.26962634
20MP0006292_abnormal_olfactory_placode2.25686757
21MP0001440_abnormal_grooming_behavior2.23081515
22MP0001501_abnormal_sleep_pattern2.09509764
23MP0002733_abnormal_thermal_nociception2.01580095
24MP0009780_abnormal_chondrocyte_physiolo2.01132673
25MP0001970_abnormal_pain_threshold1.97584138
26MP0002067_abnormal_sensory_capabilities1.92434488
27MP0005386_behavior/neurological_phenoty1.92054564
28MP0004924_abnormal_behavior1.92054564
29MP0005645_abnormal_hypothalamus_physiol1.91686111
30MP0001486_abnormal_startle_reflex1.89531823
31MP0008877_abnormal_DNA_methylation1.89094684
32MP0001905_abnormal_dopamine_level1.79647015
33MP0003123_paternal_imprinting1.79360594
34MP0002234_abnormal_pharynx_morphology1.78416149
35MP0002653_abnormal_ependyma_morphology1.78324284
36MP0005423_abnormal_somatic_nervous1.75176683
37MP0001984_abnormal_olfaction1.75030205
38MP0000751_myopathy1.73825012
39MP0002184_abnormal_innervation1.73250653
40MP0003329_amyloid_beta_deposits1.72458864
41MP0000778_abnormal_nervous_system1.68678576
42MP0003646_muscle_fatigue1.68108060
43MP0001986_abnormal_taste_sensitivity1.66114090
44MP0004043_abnormal_pH_regulation1.63198828
45MP0001919_abnormal_reproductive_system1.61491283
46MP0003879_abnormal_hair_cell1.61395528
47MP0001485_abnormal_pinna_reflex1.56603249
48MP0002557_abnormal_social/conspecific_i1.56232648
49MP0003878_abnormal_ear_physiology1.52256253
50MP0005377_hearing/vestibular/ear_phenot1.52256253
51MP0000955_abnormal_spinal_cord1.38710472
52MP0003172_abnormal_lysosome_physiology1.37772682
53MP0004811_abnormal_neuron_physiology1.37536069
54MP0005167_abnormal_blood-brain_barrier1.36406374
55MP0008789_abnormal_olfactory_epithelium1.34691262
56MP0004215_abnormal_myocardial_fiber1.34291313
57MP0002163_abnormal_gland_morphology1.32976852
58MP0004858_abnormal_nervous_system1.32598869
59MP0002066_abnormal_motor_capabilities/c1.29217677
60MP0003122_maternal_imprinting1.29002855
61MP0002882_abnormal_neuron_morphology1.27924396
62MP0006082_CNS_inflammation1.25601488
63MP0010386_abnormal_urinary_bladder1.25218668
64MP0004145_abnormal_muscle_electrophysio1.24646937
65MP0008569_lethality_at_weaning1.23433292
66MP0005646_abnormal_pituitary_gland1.23373759
67MP0004142_abnormal_muscle_tone1.23133916
68MP0002332_abnormal_exercise_endurance1.22579097
69MP0004036_abnormal_muscle_relaxation1.20846037
70MP0005389_reproductive_system_phenotype1.20502675
71MP0008872_abnormal_physiological_respon1.19847677
72MP0003868_abnormal_feces_composition1.19029113
73MP0002909_abnormal_adrenal_gland1.18171636
74MP0005551_abnormal_eye_electrophysiolog1.18133703
75MP0005535_abnormal_body_temperature1.16255698
76MP0001502_abnormal_circadian_rhythm1.14396838
77MP0004484_altered_response_of1.13081675
78MP0004085_abnormal_heartbeat1.12133157
79MP0002229_neurodegeneration1.11763705
80MP0002160_abnormal_reproductive_system1.07796346
81MP0005174_abnormal_tail_pigmentation1.06528757
82MP0003121_genomic_imprinting1.05101633
83MP0004084_abnormal_cardiac_muscle1.00084771
84MP0003633_abnormal_nervous_system0.99161597
85MP0000013_abnormal_adipose_tissue0.97661817
86MP0002876_abnormal_thyroid_physiology0.97406296
87MP0001664_abnormal_digestion0.97249242
88MP0005360_urolithiasis0.95570524
89MP0001764_abnormal_homeostasis0.94778653
90MP0009379_abnormal_foot_pigmentation0.93092567
91MP0002139_abnormal_hepatobiliary_system0.92254909
92MP0002152_abnormal_brain_morphology0.90586202
93MP0003011_delayed_dark_adaptation0.90478723
94MP0002928_abnormal_bile_duct0.90194147
95MP0004233_abnormal_muscle_weight0.89730076
96MP0008874_decreased_physiological_sensi0.88615964
97MP0003631_nervous_system_phenotype0.87823342
98MP0004133_heterotaxia0.86904781
99MP0008995_early_reproductive_senescence0.85667826
100MP0000026_abnormal_inner_ear0.83884988
101MP0003137_abnormal_impulse_conducting0.83239989
102MP0006035_abnormal_mitochondrial_morpho0.82452326
103MP0004130_abnormal_muscle_cell0.81914404
104MP0002069_abnormal_eating/drinking_beha0.81147371
105MP0004885_abnormal_endolymph0.80985771
106MP0005085_abnormal_gallbladder_physiolo0.80319270
107MP0005620_abnormal_muscle_contractility0.80111521
108MP0003283_abnormal_digestive_organ0.79957672
109MP0008875_abnormal_xenobiotic_pharmacok0.79826982
110MP0000604_amyloidosis0.79694645
111MP0002638_abnormal_pupillary_reflex0.78357917
112MP0005187_abnormal_penis_morphology0.77978680
113MP0002752_abnormal_somatic_nervous0.77223703
114MP0002233_abnormal_nose_morphology0.76454832
115MP0005394_taste/olfaction_phenotype0.74511581
116MP0005499_abnormal_olfactory_system0.74511581
117MP0005409_darkened_coat_color0.73866526
118MP0006072_abnormal_retinal_apoptosis0.72431850
119MP0001963_abnormal_hearing_physiology0.70701502
120MP0000490_abnormal_crypts_of0.70049642
121MP0002210_abnormal_sex_determination0.68868958
122MP0005379_endocrine/exocrine_gland_phen0.68777417
123MP0003634_abnormal_glial_cell0.67940113
124MP0004742_abnormal_vestibular_system0.67727997
125MP0003787_abnormal_imprinting0.67221128
126MP0001188_hyperpigmentation0.65497514
127MP0005195_abnormal_posterior_eye0.65421157
128MP0002972_abnormal_cardiac_muscle0.65300272
129MP0000631_abnormal_neuroendocrine_gland0.64818201
130MP0006036_abnormal_mitochondrial_physio0.64214842
131MP0000049_abnormal_middle_ear0.63768525
132MP0005253_abnormal_eye_physiology0.62733836
133MP0005410_abnormal_fertilization0.62378332
134MP0000230_abnormal_systemic_arterial0.59280213
135MP0003690_abnormal_glial_cell0.59219134
136MP0002102_abnormal_ear_morphology0.58096437
137MP0002090_abnormal_vision0.57469968

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.86000443
2Myokymia (HP:0002411)5.25680809
3Atonic seizures (HP:0010819)4.70303510
4Focal seizures (HP:0007359)4.31729310
5Epileptic encephalopathy (HP:0200134)4.29409507
6Pheochromocytoma (HP:0002666)4.19917281
7Neuroendocrine neoplasm (HP:0100634)3.95860395
8Visual hallucinations (HP:0002367)3.85073645
9Absence seizures (HP:0002121)3.80282882
10Hyperventilation (HP:0002883)3.77579977
11Febrile seizures (HP:0002373)3.70495015
12Generalized tonic-clonic seizures (HP:0002069)3.55687528
13Progressive cerebellar ataxia (HP:0002073)3.43018491
14Limb dystonia (HP:0002451)3.40252828
15Acute necrotizing encephalopathy (HP:0006965)3.34498908
16Dialeptic seizures (HP:0011146)3.30169158
17Abnormal mitochondria in muscle tissue (HP:0008316)3.16983969
18Supranuclear gaze palsy (HP:0000605)3.00291396
19Progressive macrocephaly (HP:0004481)3.00058857
203-Methylglutaconic aciduria (HP:0003535)2.97754277
21Progressive inability to walk (HP:0002505)2.95276009
22Amblyopia (HP:0000646)2.91899872
23Broad-based gait (HP:0002136)2.83455760
24Acute encephalopathy (HP:0006846)2.81666932
25Cerebral inclusion bodies (HP:0100314)2.76729799
26Abnormal gallbladder physiology (HP:0012438)2.68545736
27Cholecystitis (HP:0001082)2.68545736
28Gait imbalance (HP:0002141)2.68336384
29Mitochondrial inheritance (HP:0001427)2.67431439
30Hypothermia (HP:0002045)2.66053813
31Anxiety (HP:0000739)2.64291604
32Dysmetria (HP:0001310)2.64022097
33Epileptiform EEG discharges (HP:0011182)2.59164896
34Termporal pattern (HP:0011008)2.58656721
35Insidious onset (HP:0003587)2.58656721
36Truncal ataxia (HP:0002078)2.57375596
37Autoimmune thrombocytopenia (HP:0001973)2.56974686
38Failure to thrive in infancy (HP:0001531)2.56777391
39Cerebral hemorrhage (HP:0001342)2.52849382
40EEG with generalized epileptiform discharges (HP:0011198)2.50012211
41Neurofibrillary tangles (HP:0002185)2.45376943
42Pachygyria (HP:0001302)2.43665984
43Oligomenorrhea (HP:0000876)2.42400482
44Action tremor (HP:0002345)2.42288174
45Excessive salivation (HP:0003781)2.40711842
46Drooling (HP:0002307)2.40711842
47Increased serum pyruvate (HP:0003542)2.39780955
48Abnormality of glycolysis (HP:0004366)2.39780955
49Dysdiadochokinesis (HP:0002075)2.38958422
50Hypsarrhythmia (HP:0002521)2.38360146
51Abnormality of glycolipid metabolism (HP:0010969)2.37054935
52Abnormality of liposaccharide metabolism (HP:0010968)2.37054935
53Abnormality of glycosphingolipid metabolism (HP:0004343)2.37054935
54Delusions (HP:0000746)2.37015018
55Inability to walk (HP:0002540)2.36744607
56Gaze-evoked nystagmus (HP:0000640)2.36664844
57Polyphagia (HP:0002591)2.35442134
58Impaired vibration sensation in the lower limbs (HP:0002166)2.33471622
59Neoplasm of the peripheral nervous system (HP:0100007)2.33164980
60Rib fusion (HP:0000902)2.30221841
61Congenital primary aphakia (HP:0007707)2.28721621
62Mutism (HP:0002300)2.27915666
63Urinary bladder sphincter dysfunction (HP:0002839)2.27549420
64Dysostosis multiplex (HP:0000943)2.26751786
65Myotonia (HP:0002486)2.26654490
66Abnormality of the corticospinal tract (HP:0002492)2.25288742
67Depression (HP:0000716)2.25137955
68Abnormal eating behavior (HP:0100738)2.24836945
69Dysmetric saccades (HP:0000641)2.24166844
70Increased CSF lactate (HP:0002490)2.23908579
71Sudden death (HP:0001699)2.21363263
72Poor eye contact (HP:0000817)2.21254621
73Syncope (HP:0001279)2.18787187
74Agitation (HP:0000713)2.16643438
75Abnormal social behavior (HP:0012433)2.16023658
76Impaired social interactions (HP:0000735)2.16023658
77Generalized myoclonic seizures (HP:0002123)2.15850893
78Exercise-induced myalgia (HP:0003738)2.14905024
79Hemiparesis (HP:0001269)2.13571654
80Abnormality of midbrain morphology (HP:0002418)2.12759191
81Molar tooth sign on MRI (HP:0002419)2.12759191
82Medial flaring of the eyebrow (HP:0010747)2.12221571
83Tachypnea (HP:0002789)2.11537801
84Urinary urgency (HP:0000012)2.11194179
85Muscle hypertrophy of the lower extremities (HP:0008968)2.11058174
86Intestinal fistula (HP:0100819)2.10081359
87Lip pit (HP:0100267)2.08125451
88Nephrogenic diabetes insipidus (HP:0009806)2.07639683
89Optic disc pallor (HP:0000543)2.06034497
90Cerebral edema (HP:0002181)2.05806499
91Hepatocellular necrosis (HP:0001404)2.05543912
92Septo-optic dysplasia (HP:0100842)2.05406616
93Bradycardia (HP:0001662)2.05377067
94Genetic anticipation (HP:0003743)2.05344369
95Congenital stationary night blindness (HP:0007642)2.04994878
96Poor suck (HP:0002033)2.04570607
97Abnormality of salivation (HP:0100755)2.02659142
98Status epilepticus (HP:0002133)2.02359345
99Central scotoma (HP:0000603)2.01531314
100Scanning speech (HP:0002168)2.00530694
101Abnormal rod and cone electroretinograms (HP:0008323)1.98954986
102Sleep apnea (HP:0010535)1.97964852
103Spastic gait (HP:0002064)1.97168752
104Depressed nasal tip (HP:0000437)1.96580932
105Athetosis (HP:0002305)1.95854780
106Spastic tetraplegia (HP:0002510)1.95369617
107Genital tract atresia (HP:0001827)1.95199540
108Optic nerve hypoplasia (HP:0000609)1.94955221
109Nephronophthisis (HP:0000090)1.94401808
110Hepatic necrosis (HP:0002605)1.94312318
111Calf muscle hypertrophy (HP:0008981)1.93327160
112Vaginal atresia (HP:0000148)1.93325065
113Specific learning disability (HP:0001328)1.92621091
114Abnormal hair whorl (HP:0010721)1.91843887
115Aplasia/Hypoplasia of the brainstem (HP:0007362)1.90570342
116Hypoplasia of the brainstem (HP:0002365)1.90570342
117Psychosis (HP:0000709)1.90244879
118Ankle clonus (HP:0011448)1.90150516
119Broad alveolar ridges (HP:0000187)1.89938107
120Left ventricular hypertrophy (HP:0001712)1.89818813
121Torticollis (HP:0000473)1.89628514
122Bradykinesia (HP:0002067)1.89551295
123Lissencephaly (HP:0001339)1.88814434
124Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86819777
125Generalized aminoaciduria (HP:0002909)1.86325515
126Prolonged QT interval (HP:0001657)1.85207992
127Osteomalacia (HP:0002749)1.84938425
128Primary atrial arrhythmia (HP:0001692)1.84426957
129Bundle branch block (HP:0011710)1.82044378
130Focal dystonia (HP:0004373)1.81622354
131Anosmia (HP:0000458)1.81345995
132Diplopia (HP:0000651)1.80944483
133Abnormality of binocular vision (HP:0011514)1.80944483
134Adrenal hypoplasia (HP:0000835)1.80544235
135Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80178928
136Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79360480
137Degeneration of the lateral corticospinal tracts (HP:0002314)1.79360480
138Protruding tongue (HP:0010808)1.79143148
139Atrial fibrillation (HP:0005110)1.78065583
140Abnormal drinking behavior (HP:0030082)1.77019414
141Polydipsia (HP:0001959)1.77019414
142Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76461217
143Abnormality of alanine metabolism (HP:0010916)1.76461217
144Hyperalaninemia (HP:0003348)1.76461217
145Short 5th finger (HP:0009237)1.74896134
146Increased intramyocellular lipid droplets (HP:0012240)1.72923087
147Severe muscular hypotonia (HP:0006829)1.72707275
148Abnormal respiratory motile cilium morphology (HP:0005938)1.72248440
149Abnormal respiratory epithelium morphology (HP:0012253)1.72248440
150Intellectual disability, severe (HP:0010864)1.71572962
151Supraventricular tachycardia (HP:0004755)1.70912460
152Narrow forehead (HP:0000341)1.70844962
153Flat capital femoral epiphysis (HP:0003370)1.69182318
154Muscular hypotonia of the trunk (HP:0008936)1.68059889
155Neonatal onset (HP:0003623)1.67459150
156Abnormality of polysaccharide metabolism (HP:0011012)1.65744085
157Abnormality of glycosaminoglycan metabolism (HP:0004371)1.65744085
158Abnormality of mucopolysaccharide metabolism (HP:0011020)1.65744085
159Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.64697395
160Reticulocytopenia (HP:0001896)1.63431911

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK13.90558756
2STK243.39707996
3EPHA43.38745127
4NTRK33.18446585
5MAP3K43.16430767
6MAP3K123.02292384
7MAP3K92.94598561
8STK162.92744151
9MARK12.87924499
10MAP2K72.57170112
11CASK2.44478173
12MINK12.39922836
13GRK52.24812170
14NME12.20204439
15MAP2K42.11789035
16MAPKAPK32.07707440
17BMPR21.95348882
18KSR21.89389395
19PLK21.85052899
20PNCK1.77463004
21DYRK31.73384914
22RIPK41.72465324
23MAPK131.68498637
24ARAF1.63095320
25WNK31.56525949
26DAPK21.53696452
27PAK61.52979350
28GRK71.52803540
29LATS21.51065523
30NTRK21.50943520
31ADRBK21.47954101
32PRKD31.47543415
33GRK11.44883424
34NTRK11.43873253
35MAP4K21.42419174
36MAP3K111.37761663
37KSR11.32766220
38MAP3K131.32046994
39ZAK1.31394236
40PHKG21.30578658
41PHKG11.30578658
42CAMK2A1.25496871
43SIK21.25204843
44PDK31.24458498
45PDK41.24458498
46CDK51.19997478
47TNK21.17746103
48AKT31.16546857
49CAMK41.16449162
50CAMK2B1.14427629
51CSNK1G21.12381699
52MOS1.12114084
53FRK1.11903364
54PTK2B1.09077510
55MAP3K61.08971244
56PRKCQ1.08225993
57SGK2231.07455723
58SGK4941.07455723
59DAPK11.04758304
60DYRK21.01936274
61PRKCG1.01159886
62RPS6KA60.98769453
63MAPKAPK50.96861547
64MATK0.92377628
65TLK10.90681467
66SIK30.90549086
67CAMK2D0.90355529
68TAOK10.89100470
69PAK30.88750296
70CDK190.88370330
71RET0.87816784
72RPS6KC10.87648469
73RPS6KL10.87648469
74UHMK10.87077519
75CCNB10.86700092
76BRAF0.86579290
77PRKCE0.86252389
78CSNK1G30.85360262
79RAF10.82141509
80EPHB20.78153081
81FGR0.77490418
82SGK20.76884488
83OXSR10.75285315
84ERBB40.72606122
85TAOK30.71263310
86FES0.71247670
87RPS6KA20.71215120
88MAP2K10.70732815
89MUSK0.70420748
90MYLK0.69857814
91CDK180.69799020
92TXK0.69402098
93BMPR1B0.66942196
94CAMK2G0.66751770
95MAPK120.66493441
96CDK140.66427955
97CAMK1D0.65627015
98CDK150.64735935
99ADRBK10.63722227
100CAMKK10.61496191
101MAPK70.60597432
102CAMK10.60185953
103MAPK150.59712616
104OBSCN0.58260842
105STK390.58209993
106TNIK0.57924089
107INSRR0.56311258
108PRKCH0.54812055
109LMTK20.53624856
110PLK40.53343897
111SYK0.53015614
112CAMKK20.52001375
113DYRK1A0.51659759
114SGK30.51552515
115MARK20.51400365
116WNK40.51121795
117TYRO30.50517857
118ROCK20.50080654
119CAMK1G0.48388122
120CDK11A0.48269823
121CDK30.48028186
122BCKDK0.47907964
123BCR0.45947567
124SGK10.45484559
125DYRK1B0.44659244
126PIK3CA0.43888783
127PRKCZ0.43675191
128GRK60.43600114
129WNK10.43010263
130PRKACA0.41566740
131CDK90.41347575
132ERBB20.41269880
133ILK0.40786206
134IRAK20.40418109
135MAP3K20.39926678
136JAK30.39556783
137MAP3K10.38852243
138CSNK1G10.37832695
139CDC42BPA0.37434872
140PKN10.37317783
141PRKCA0.34245511
142STK110.33978492
143MAP3K70.33914848
144CHEK20.33848778
145PRKG10.32394439
146TRIM280.31534651
147MAP3K50.30550381

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.38903889
2Synaptic vesicle cycle_Homo sapiens_hsa047213.19370894
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.90325016
4Oxidative phosphorylation_Homo sapiens_hsa001902.67800089
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.42346311
6Collecting duct acid secretion_Homo sapiens_hsa049662.35367782
7GABAergic synapse_Homo sapiens_hsa047272.33747086
8Parkinsons disease_Homo sapiens_hsa050122.23916602
9Selenocompound metabolism_Homo sapiens_hsa004502.14550189
10Regulation of autophagy_Homo sapiens_hsa041402.09052296
11Olfactory transduction_Homo sapiens_hsa047402.06533541
12Morphine addiction_Homo sapiens_hsa050322.05468759
13Circadian entrainment_Homo sapiens_hsa047132.02962625
14Long-term potentiation_Homo sapiens_hsa047201.97997589
15Alzheimers disease_Homo sapiens_hsa050101.96046684
16Cardiac muscle contraction_Homo sapiens_hsa042601.92795914
17Amphetamine addiction_Homo sapiens_hsa050311.92256684
18Glutamatergic synapse_Homo sapiens_hsa047241.89675680
19Ribosome_Homo sapiens_hsa030101.87299384
20Dopaminergic synapse_Homo sapiens_hsa047281.83326908
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.80615543
22Taste transduction_Homo sapiens_hsa047421.69249248
23RNA polymerase_Homo sapiens_hsa030201.67464871
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.65027133
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.63355955
26Insulin secretion_Homo sapiens_hsa049111.62157709
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60568462
28Salivary secretion_Homo sapiens_hsa049701.58754568
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.53304295
30Renin secretion_Homo sapiens_hsa049241.52593711
31Serotonergic synapse_Homo sapiens_hsa047261.50097472
32Vibrio cholerae infection_Homo sapiens_hsa051101.49675535
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49471883
34Cholinergic synapse_Homo sapiens_hsa047251.46334667
35Cocaine addiction_Homo sapiens_hsa050301.45121330
36Huntingtons disease_Homo sapiens_hsa050161.43213081
37Long-term depression_Homo sapiens_hsa047301.40412343
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39581109
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35871797
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33834627
41Gastric acid secretion_Homo sapiens_hsa049711.29641585
42Sulfur relay system_Homo sapiens_hsa041221.27478207
43Oxytocin signaling pathway_Homo sapiens_hsa049211.26591372
44Calcium signaling pathway_Homo sapiens_hsa040201.22935641
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21607488
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16222351
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13765124
48Butanoate metabolism_Homo sapiens_hsa006501.10490474
49Folate biosynthesis_Homo sapiens_hsa007901.08381287
50GnRH signaling pathway_Homo sapiens_hsa049121.08222220
51Phototransduction_Homo sapiens_hsa047441.07109715
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.06953158
53Gap junction_Homo sapiens_hsa045401.06897466
54Pyruvate metabolism_Homo sapiens_hsa006201.06049389
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96236363
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95123560
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94585201
58Lysosome_Homo sapiens_hsa041420.91686761
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90720065
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90141867
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88548655
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.86750459
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86099596
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84739425
65cAMP signaling pathway_Homo sapiens_hsa040240.82030571
66Estrogen signaling pathway_Homo sapiens_hsa049150.81960581
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81356147
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79838313
69Pancreatic secretion_Homo sapiens_hsa049720.79585008
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78895200
71AMPK signaling pathway_Homo sapiens_hsa041520.78478109
72Axon guidance_Homo sapiens_hsa043600.75854306
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74391086
74Bile secretion_Homo sapiens_hsa049760.74305578
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73812255
76Dilated cardiomyopathy_Homo sapiens_hsa054140.72861725
77Glucagon signaling pathway_Homo sapiens_hsa049220.71372374
78Type II diabetes mellitus_Homo sapiens_hsa049300.71142999
79Basal transcription factors_Homo sapiens_hsa030220.68790400
80Peroxisome_Homo sapiens_hsa041460.66086312
81Propanoate metabolism_Homo sapiens_hsa006400.65897537
82Dorso-ventral axis formation_Homo sapiens_hsa043200.64697223
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64437538
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64345811
85Basal cell carcinoma_Homo sapiens_hsa052170.63116987
86Ether lipid metabolism_Homo sapiens_hsa005650.62363098
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.61821476
88Oocyte meiosis_Homo sapiens_hsa041140.59947828
89Melanogenesis_Homo sapiens_hsa049160.58418403
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.58351405
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58257890
92African trypanosomiasis_Homo sapiens_hsa051430.57561199
93ErbB signaling pathway_Homo sapiens_hsa040120.56959463
94Steroid biosynthesis_Homo sapiens_hsa001000.56760316
95Glioma_Homo sapiens_hsa052140.56583186
96Ovarian steroidogenesis_Homo sapiens_hsa049130.54431027
97Fatty acid elongation_Homo sapiens_hsa000620.54273084
98Type I diabetes mellitus_Homo sapiens_hsa049400.53673690
99Arginine biosynthesis_Homo sapiens_hsa002200.51923965
100Hedgehog signaling pathway_Homo sapiens_hsa043400.51058659
101Sulfur metabolism_Homo sapiens_hsa009200.50985609
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50649547
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49408435
104Linoleic acid metabolism_Homo sapiens_hsa005910.48370762
105Rheumatoid arthritis_Homo sapiens_hsa053230.47742518
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47538783
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.47350501
108Circadian rhythm_Homo sapiens_hsa047100.46122347
109Fat digestion and absorption_Homo sapiens_hsa049750.46101036
110Phagosome_Homo sapiens_hsa041450.45142603
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44571339
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44267013
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42639680
114Protein export_Homo sapiens_hsa030600.42141668
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41695571
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41559386
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40012073
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38718683
119Insulin signaling pathway_Homo sapiens_hsa049100.37088252
120Purine metabolism_Homo sapiens_hsa002300.36829102
121MAPK signaling pathway_Homo sapiens_hsa040100.36303303
122Ras signaling pathway_Homo sapiens_hsa040140.36039107
123Salmonella infection_Homo sapiens_hsa051320.36030996
124Thyroid hormone synthesis_Homo sapiens_hsa049180.35818299
125Carbon metabolism_Homo sapiens_hsa012000.35329794
126Alcoholism_Homo sapiens_hsa050340.35084668
127Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34849950
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.34490074
129Phenylalanine metabolism_Homo sapiens_hsa003600.34473142
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.34443391
131PPAR signaling pathway_Homo sapiens_hsa033200.33800032
132Choline metabolism in cancer_Homo sapiens_hsa052310.33464750
133VEGF signaling pathway_Homo sapiens_hsa043700.33282516
134Renal cell carcinoma_Homo sapiens_hsa052110.32986075
135Pyrimidine metabolism_Homo sapiens_hsa002400.32275589
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31171224
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30206300
138Metabolic pathways_Homo sapiens_hsa011000.30138256
139RNA degradation_Homo sapiens_hsa030180.29585840
140Retinol metabolism_Homo sapiens_hsa008300.26061146
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.23123045

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