LYST

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that regulates intracellular protein trafficking in endosomes, and may be involved in pigmentation. Mutations in this gene are associated with Chediak-Higashi syndrome, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants, though the full-length nature of some of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.90130802
2negative regulation of cell killing (GO:0031342)5.72586471
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.72586471
4detection of molecule of bacterial origin (GO:0032490)5.47964063
5microglial cell activation (GO:0001774)5.30810434
6cellular extravasation (GO:0045123)4.97565756
7positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.74118838
8positive regulation by symbiont of host defense response (GO:0052509)4.47550080
9modulation by symbiont of host defense response (GO:0052031)4.47550080
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.47550080
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.47550080
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.47550080
13modulation by symbiont of host immune response (GO:0052553)4.47550080
14positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.41176928
15detection of external biotic stimulus (GO:0098581)4.37017452
16detection of other organism (GO:0098543)4.30901696
17macrophage activation (GO:0042116)4.30873094
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.30418084
19neutrophil activation involved in immune response (GO:0002283)4.24345982
20regulation of B cell receptor signaling pathway (GO:0050855)4.21903013
21regulation of gamma-delta T cell activation (GO:0046643)4.11029375
22negative regulation of interleukin-12 production (GO:0032695)4.08402742
23negative regulation of T cell mediated immunity (GO:0002710)4.04521186
24regulation of interferon-beta biosynthetic process (GO:0045357)3.98407484
25negative regulation of lymphocyte mediated immunity (GO:0002707)3.94036269
26detection of biotic stimulus (GO:0009595)3.91857156
27histone H3-K4 trimethylation (GO:0080182)3.91731132
28regulation of gamma-delta T cell differentiation (GO:0045586)3.85621116
29response to muramyl dipeptide (GO:0032495)3.84843404
30positive regulation of B cell differentiation (GO:0045579)3.81125932
31positive thymic T cell selection (GO:0045059)3.79011978
32germinal center formation (GO:0002467)3.77977516
33response to interleukin-15 (GO:0070672)3.77637691
34NIK/NF-kappaB signaling (GO:0038061)3.76896759
35macrophage activation involved in immune response (GO:0002281)3.72437630
36activated T cell proliferation (GO:0050798)3.69429699
37detection of bacterium (GO:0016045)3.66302048
38hepatocyte apoptotic process (GO:0097284)3.61749499
39neutrophil activation (GO:0042119)3.57984850
40B cell homeostasis (GO:0001782)3.55805684
41antigen processing and presentation via MHC class Ib (GO:0002475)3.52335032
42I-kappaB phosphorylation (GO:0007252)3.49721819
43cellular response to interleukin-15 (GO:0071350)3.49006336
44B cell receptor signaling pathway (GO:0050853)3.48795981
45positive regulation of granulocyte differentiation (GO:0030854)3.43386644
46negative regulation of interleukin-1 beta production (GO:0032691)3.40580028
47positive regulation of cellular amide metabolic process (GO:0034250)3.40073654
48regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.40053994
49regulation of interleukin-12 biosynthetic process (GO:0045075)3.33498187
50negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.32818005
51granulocyte activation (GO:0036230)3.31582319
52negative regulation of leukocyte mediated immunity (GO:0002704)3.31180324
53* myeloid leukocyte mediated immunity (GO:0002444)3.26780880
54leukocyte aggregation (GO:0070486)3.24502348
55positive T cell selection (GO:0043368)3.23747813
56response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.23740187
57response to host immune response (GO:0052572)3.23740187
58negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.23464236
59regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.22664008
60macroautophagy (GO:0016236)3.20688357
61positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.20568870
62myeloid cell activation involved in immune response (GO:0002275)3.19919720
63modulation by symbiont of host cellular process (GO:0044068)3.19048723
64response to peptidoglycan (GO:0032494)3.17352947
65negative regulation of granulocyte differentiation (GO:0030853)3.13958154
66T cell migration (GO:0072678)3.12566106
67interferon-gamma production (GO:0032609)3.10924455
68negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.10921413
69regulation of B cell differentiation (GO:0045577)3.10097150
70positive regulation of mast cell activation (GO:0033005)3.09267614
71negative regulation of B cell proliferation (GO:0030889)3.08737405
72negative thymic T cell selection (GO:0045060)3.05441731
73production of molecular mediator involved in inflammatory response (GO:0002532)3.04753570
74negative regulation of adaptive immune response (GO:0002820)3.03902911
75regulation of alpha-beta T cell proliferation (GO:0046640)3.01401724
76negative T cell selection (GO:0043383)3.00671585
77negative regulation of lipid storage (GO:0010888)2.99411538
78response to host (GO:0075136)2.98783925
79response to host defenses (GO:0052200)2.98783925
80response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.98783925
81dendritic cell migration (GO:0036336)2.97020328
82regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.92589981
83regulation of tolerance induction (GO:0002643)2.91569914
84negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.91523133
85negative regulation of T-helper cell differentiation (GO:0045623)2.91523133
86cellular response to ethanol (GO:0071361)2.86860750
87negative regulation of interleukin-1 production (GO:0032692)2.86789172
88* neutrophil mediated immunity (GO:0002446)2.85250332
89myeloid leukocyte activation (GO:0002274)2.82567950
90regulation of necroptotic process (GO:0060544)2.82003777
91negative regulation of interleukin-17 production (GO:0032700)2.81404258
92positive regulation of tolerance induction (GO:0002645)2.78219621
93positive regulation of antigen processing and presentation (GO:0002579)2.78126945
94mature B cell differentiation (GO:0002335)2.77785900
95regulation of interleukin-6 biosynthetic process (GO:0045408)2.77579158
96B cell proliferation (GO:0042100)2.76004618
97negative regulation of immunoglobulin mediated immune response (GO:0002890)2.74987780
98negative regulation of B cell mediated immunity (GO:0002713)2.74987780
99leukocyte migration involved in inflammatory response (GO:0002523)2.74632027
100lipoprotein transport (GO:0042953)2.74126338
101T cell proliferation (GO:0042098)2.73861338
102immunoglobulin mediated immune response (GO:0016064)2.73647362
103positive regulation of cholesterol efflux (GO:0010875)2.72071074
104positive regulation of interferon-alpha production (GO:0032727)2.72069275
105histone H3-K4 methylation (GO:0051568)2.71830871
106regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.70971722
107G-protein coupled receptor internalization (GO:0002031)2.68239347
108developmental pigmentation (GO:0048066)2.67914008
109cytokine secretion (GO:0050663)2.67867603
110phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.65030967
111respiratory burst (GO:0045730)2.62509261
112positive regulation of p38MAPK cascade (GO:1900745)2.60823413
113regulation of germinal center formation (GO:0002634)2.59362007
114regulation of interferon-alpha production (GO:0032647)2.58886029
115regulation of integrin activation (GO:0033623)2.56766242
116positive regulation of humoral immune response (GO:0002922)2.54274960
117negative regulation of translation, ncRNA-mediated (GO:0040033)2.54082972
118regulation of translation, ncRNA-mediated (GO:0045974)2.54082972
119negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.54082972
120regulation of myeloid leukocyte mediated immunity (GO:0002886)2.53649518
121regulation of dendritic cell antigen processing and presentation (GO:0002604)2.52288194
122pinocytosis (GO:0006907)2.52106220
123negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.51747915
124Golgi to endosome transport (GO:0006895)2.51727020
125regulation of mast cell degranulation (GO:0043304)2.51604026
126regulation of leukocyte degranulation (GO:0043300)2.51530066
127T cell selection (GO:0045058)2.51451164
128peptidyl-lysine trimethylation (GO:0018023)2.50441143
129regulation of ARF protein signal transduction (GO:0032012)2.49872038
130regulation of protein polyubiquitination (GO:1902914)2.47612067
131cytoplasmic mRNA processing body assembly (GO:0033962)2.46918100
132thymic T cell selection (GO:0045061)2.46254517
133antigen processing and presentation of endogenous antigen (GO:0019883)2.44884692
134lymphocyte homeostasis (GO:0002260)2.43468165
135histone H3-K36 demethylation (GO:0070544)2.43090213
136regulation of mast cell activation involved in immune response (GO:0033006)2.42699130
137negative regulation of interleukin-6 production (GO:0032715)2.42627224
138positive regulation of cholesterol transport (GO:0032376)2.41891862
139positive regulation of sterol transport (GO:0032373)2.41891862
140antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.41479493
141antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.41479493
142positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.41406139
143leukocyte cell-cell adhesion (GO:0007159)2.40083942
144mannose metabolic process (GO:0006013)2.38174840
145leukocyte degranulation (GO:0043299)2.36043553
146regulation of mast cell activation (GO:0033003)2.35908571
147negative regulation of toll-like receptor signaling pathway (GO:0034122)2.34662060

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.77753542
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.95159128
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.86125341
4SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.62069238
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.52678776
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.44593833
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.25664948
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.00149263
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.84876374
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.77466498
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.75080132
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.70633884
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.62999064
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.59004966
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.53099356
16SPI1_23127762_ChIP-Seq_K562_Human2.44502126
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.38408458
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.23070094
19RUNX_20019798_ChIP-Seq_JUKART_Human2.20160673
20* SCL_19346495_ChIP-Seq_HPC-7_Human2.18784671
21* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.18202355
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.04779080
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.98533254
24BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92693152
25GATA1_22025678_ChIP-Seq_K562_Human1.90947844
26GATA2_21666600_ChIP-Seq_HMVEC_Human1.85868147
27PU_27001747_Chip-Seq_BMDM_Mouse1.67078481
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66213090
29* VDR_24787735_ChIP-Seq_THP-1_Human1.65689859
30PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.63143458
31PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.61499544
32TCF7_22412390_ChIP-Seq_EML_Mouse1.61468588
33MYB_26560356_Chip-Seq_TH1_Human1.60945330
34* VDR_24763502_ChIP-Seq_THP-1_Human1.57435688
35* VDR_21846776_ChIP-Seq_THP-1_Human1.54732910
36NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.53358336
37* MYB_26560356_Chip-Seq_TH2_Human1.52981610
38MAF_26560356_Chip-Seq_TH1_Human1.48683866
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.47968726
40* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46285233
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43668920
42* SPI1_23547873_ChIP-Seq_NB4_Human1.42879498
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.39097294
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37256761
45GATA3_27048872_Chip-Seq_THYMUS_Human1.31796976
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30206266
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30098014
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25179589
49* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23880113
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23651417
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22892348
52* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21608816
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.19252732
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17057500
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16467447
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16410904
57FOXA2_19822575_ChIP-Seq_HepG2_Human1.15275357
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15086922
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13995525
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.12890661
61NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12695844
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10522134
63* KDM2B_26808549_Chip-Seq_DND41_Human1.10312993
64DROSHA_22980978_ChIP-Seq_HELA_Human1.09773028
65* UTX_26944678_Chip-Seq_JUKART_Human1.08712529
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07632409
67GATA2_19941826_ChIP-Seq_K562_Human1.07405147
68MYC_22102868_ChIP-Seq_BL_Human1.05931117
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04467034
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.04245464
71TP53_16413492_ChIP-PET_HCT116_Human1.04195544
72* GATA3_26560356_Chip-Seq_TH2_Human1.02878012
73AHR_22903824_ChIP-Seq_MCF-7_Human1.02352494
74* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01836082
75GATA1_19941827_ChIP-Seq_MEL86_Mouse1.00681255
76CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00638666
77ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99506896
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98501251
79RXR_22108803_ChIP-Seq_LS180_Human0.98134264
80* MAF_26560356_Chip-Seq_TH2_Human0.95814326
81* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94258358
82* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94137003
83GATA1_19941826_ChIP-Seq_K562_Human0.93680005
84* LXR_22158963_ChIP-Seq_LIVER_Mouse0.91778501
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90996648
86E2F7_22180533_ChIP-Seq_HELA_Human0.90758090
87* ARNT_22903824_ChIP-Seq_MCF-7_Human0.90322452
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89939669
89* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89933197
90KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89270959
91* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89179986
92* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87735134
93* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87229840
94ER_23166858_ChIP-Seq_MCF-7_Human0.86887536
95DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84643033
96PRDM14_20953172_ChIP-Seq_ESCs_Human0.83320045
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83022589
98FLI1_27457419_Chip-Seq_LIVER_Mouse0.82502972
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82479425
100* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81822976
101SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.81289315
102EZH2_27294783_Chip-Seq_NPCs_Mouse0.80754675
103PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80443578
104ESR1_20079471_ChIP-ChIP_T-47D_Human0.79587999
105SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.79114469
106SUZ12_27294783_Chip-Seq_NPCs_Mouse0.78390209
107SMRT_27268052_Chip-Seq_Bcells_Human0.78150479
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.77794223
109NFE2_27457419_Chip-Seq_LIVER_Mouse0.77318067
110* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.76893199
111* BRD4_25478319_ChIP-Seq_HGPS_Human0.76664548
112* STAT3_23295773_ChIP-Seq_U87_Human0.76478450
113VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.76087878
114SALL4_22934838_ChIP-ChIP_CD34+_Human0.75799412
115OCT4_21477851_ChIP-Seq_ESCs_Mouse0.75549146
116PPAR_26484153_Chip-Seq_NCI-H1993_Human0.75031769
117* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74630171
118FOXM1_23109430_ChIP-Seq_U2OS_Human0.73787646
119* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72899598
120NFIB_24661679_ChIP-Seq_LUNG_Mouse0.72474040
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.72326720
122* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.70295991
123CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70023471
124* TCF4_23295773_ChIP-Seq_U87_Human0.69832614
125GATA3_26560356_Chip-Seq_TH1_Human0.69407182

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0000569_abnormal_digit_pigmentation4.95078747
2MP0004510_myositis3.81353712
3MP0003183_abnormal_peptide_metabolism3.41552292
4* MP0001835_abnormal_antigen_presentation3.01769084
5MP0009278_abnormal_bone_marrow2.91008088
6MP0003300_gastrointestinal_ulcer2.81015299
7MP0003436_decreased_susceptibility_to2.68615538
8MP0003303_peritoneal_inflammation2.65253845
9* MP0002419_abnormal_innate_immunity2.65167175
10* MP0001800_abnormal_humoral_immune2.62970849
11MP0005387_immune_system_phenotype2.51273220
12MP0001790_abnormal_immune_system2.51273220
13MP0000685_abnormal_immune_system2.47195351
14* MP0002452_abnormal_antigen_presenting2.34620133
15MP0005000_abnormal_immune_tolerance2.19250938
16* MP0002723_abnormal_immune_serum2.16827315
17MP0002396_abnormal_hematopoietic_system2.13581771
18* MP0005174_abnormal_tail_pigmentation2.13460498
19* MP0003172_abnormal_lysosome_physiology2.09684099
20MP0004947_skin_inflammation2.07313967
21* MP0002420_abnormal_adaptive_immunity2.06914336
22* MP0001819_abnormal_immune_cell2.06381783
23* MP0005464_abnormal_platelet_physiology2.04452125
24MP0005671_abnormal_response_to1.99299297
25* MP0000371_diluted_coat_color1.94072356
26MP0003828_pulmonary_edema1.92280491
27* MP0005025_abnormal_response_to1.91114990
28MP0004883_abnormal_blood_vessel1.90062403
29* MP0004381_abnormal_hair_follicle1.82799750
30MP0001873_stomach_inflammation1.79170159
31* MP0005058_abnormal_lysosome_morphology1.76157809
32MP0005397_hematopoietic_system_phenotyp1.74262109
33MP0001545_abnormal_hematopoietic_system1.74262109
34* MP0002398_abnormal_bone_marrow1.69677253
35MP0009785_altered_susceptibility_to1.68435155
36MP0005451_abnormal_body_composition1.68021144
37MP0008057_abnormal_DNA_replication1.65552990
38MP0002928_abnormal_bile_duct1.65354623
39* MP0000716_abnormal_immune_system1.60966209
40* MP0002166_altered_tumor_susceptibility1.60953653
41* MP0000015_abnormal_ear_pigmentation1.59967546
42MP0010307_abnormal_tumor_latency1.59664110
43MP0004808_abnormal_hematopoietic_stem1.57374081
44MP0003787_abnormal_imprinting1.56989148
45MP0002405_respiratory_system_inflammati1.53100216
46MP0005076_abnormal_cell_differentiation1.50809835
47* MP0000689_abnormal_spleen_morphology1.48299361
48* MP0005075_abnormal_melanosome_morpholog1.46615224
49MP0005164_abnormal_response_to1.41948076
50MP0005257_abnormal_intraocular_pressure1.41547348
51MP0001845_abnormal_inflammatory_respons1.41304868
52MP0000604_amyloidosis1.40142304
53MP0002254_reproductive_system_inflammat1.38238121
54MP0003045_fibrosis1.36281680
55MP0003763_abnormal_thymus_physiology1.34441881
56MP0003091_abnormal_cell_migration1.33798826
57MP0002138_abnormal_hepatobiliary_system1.31651077
58MP0006082_CNS_inflammation1.29978292
59MP0003566_abnormal_cell_adhesion1.28882652
60MP0002148_abnormal_hypersensitivity_rea1.28050138
61* MP0002722_abnormal_immune_system1.27678114
62MP0003448_altered_tumor_morphology1.26702331
63MP0001853_heart_inflammation1.26639382
64MP0008260_abnormal_autophagy1.26610098
65* MP0002429_abnormal_blood_cell1.26368703
66* MP0002006_tumorigenesis1.22101191
67MP0003221_abnormal_cardiomyocyte_apopto1.21882235
68MP0003191_abnormal_cellular_cholesterol1.19303817
69MP0002132_abnormal_respiratory_system1.18904423
70MP0010155_abnormal_intestine_physiology1.17586594
71MP0009333_abnormal_splenocyte_physiolog1.17212065
72MP0001533_abnormal_skeleton_physiology1.14889585
73MP0004484_altered_response_of1.14721645
74* MP0000703_abnormal_thymus_morphology1.12648700
75MP0002998_abnormal_bone_remodeling1.10155220
76MP0008877_abnormal_DNA_methylation1.07312392
77MP0002877_abnormal_melanocyte_morpholog1.06809464
78MP0001851_eye_inflammation1.05118420
79MP0008469_abnormal_protein_level1.04847157
80MP0002009_preneoplasia1.04240392
81MP0003656_abnormal_erythrocyte_physiolo1.03257015
82MP0009697_abnormal_copulation1.02285058
83MP0000465_gastrointestinal_hemorrhage1.00818028
84MP0005409_darkened_coat_color0.95831695
85MP0009764_decreased_sensitivity_to0.94519198
86MP0002332_abnormal_exercise_endurance0.93973190
87MP0003690_abnormal_glial_cell0.93919541
88* MP0002095_abnormal_skin_pigmentation0.92374368
89MP0005310_abnormal_salivary_gland0.92012514
90MP0002933_joint_inflammation0.91929844
91MP0004130_abnormal_muscle_cell0.91595773
92* MP0002075_abnormal_coat/hair_pigmentati0.91567811
93MP0005167_abnormal_blood-brain_barrier0.91505127
94MP0009763_increased_sensitivity_to0.91155295
95MP0008961_abnormal_basal_metabolism0.90675524
96MP0003453_abnormal_keratinocyte_physiol0.88013886
97MP0005621_abnormal_cell_physiology0.85588028
98MP0010352_gastrointestinal_tract_polyps0.82486975
99MP0003075_altered_response_to0.81034892
100MP0003279_aneurysm0.79950827
101* MP0000858_altered_metastatic_potential0.78945226
102MP0009765_abnormal_xenobiotic_induced0.78844744
103MP0003724_increased_susceptibility_to0.78343585
104MP0000372_irregular_coat_pigmentation0.77828758
105MP0000609_abnormal_liver_physiology0.77706815
106MP0003866_abnormal_defecation0.76859143
107MP0005166_decreased_susceptibility_to0.76512055
108MP0003252_abnormal_bile_duct0.76013354
109MP0009840_abnormal_foam_cell0.75373303
110MP0005171_absent_coat_pigmentation0.74146329
111MP0000767_abnormal_smooth_muscle0.72481786
112MP0002277_abnormal_respiratory_mucosa0.68543848
113MP0000249_abnormal_blood_vessel0.68494770
114MP0002168_other_aberrant_phenotype0.67225137
115* MP0001186_pigmentation_phenotype0.67129543
116MP0001915_intracranial_hemorrhage0.66685727
117MP0005376_homeostasis/metabolism_phenot0.66334360
118MP0005670_abnormal_white_adipose0.64616000
119MP0006054_spinal_hemorrhage0.62808753
120MP0001663_abnormal_digestive_system0.62743948
121MP0003329_amyloid_beta_deposits0.62636576
122MP0008874_decreased_physiological_sensi0.58157498
123MP0008004_abnormal_stomach_pH0.57288944
124* MP0002019_abnormal_tumor_incidence0.54486346

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal infarctions (HP:0005244)4.33015153
2Abnormality of the fingertips (HP:0001211)4.23196655
3Eczematoid dermatitis (HP:0000976)4.17878746
4* Recurrent abscess formation (HP:0002722)4.11532591
5* Recurrent bacterial skin infections (HP:0005406)3.81415351
6Keratoconjunctivitis sicca (HP:0001097)3.77663442
7Recurrent fungal infections (HP:0002841)3.72400693
8Recurrent gram-negative bacterial infections (HP:0005420)3.63869427
9Keratoconjunctivitis (HP:0001096)3.53528973
10Stomatitis (HP:0010280)3.51410933
11Spontaneous hematomas (HP:0007420)3.41622977
12Absent frontal sinuses (HP:0002688)3.32745215
13Chest pain (HP:0100749)3.31355453
14Encephalitis (HP:0002383)3.27928211
15Abnormality of T cells (HP:0002843)3.27895551
16Recurrent viral infections (HP:0004429)3.26052120
17Mediastinal lymphadenopathy (HP:0100721)3.24253481
18Hemoptysis (HP:0002105)3.16692152
19Peritonitis (HP:0002586)3.14719827
20Autoimmune thrombocytopenia (HP:0001973)3.10936799
21Colitis (HP:0002583)2.99899637
22Abnormality of macrophages (HP:0004311)2.96327298
23Chronic mucocutaneous candidiasis (HP:0002728)2.95156244
24Recurrent cutaneous fungal infections (HP:0011370)2.95156244
25Elevated erythrocyte sedimentation rate (HP:0003565)2.93879219
26Urticaria (HP:0001025)2.81893080
27* Recurrent skin infections (HP:0001581)2.76073231
28* Gingival bleeding (HP:0000225)2.71728239
29Subacute progressive viral hepatitis (HP:0006572)2.71488526
30* Gingivitis (HP:0000230)2.68614575
31Pulmonary embolism (HP:0002204)2.59500369
32Eosinophilia (HP:0001880)2.57859247
33Vasculitis (HP:0002633)2.56819299
34Hematochezia (HP:0002573)2.56181012
35Prostate neoplasm (HP:0100787)2.52569180
36Thick nail (HP:0001805)2.51322534
37Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.50992593
38Gangrene (HP:0100758)2.50433291
39Thyroiditis (HP:0100646)2.50037396
40Recurrent bronchitis (HP:0002837)2.49617680
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.48411210
42Myositis (HP:0100614)2.47474158
43Osteomyelitis (HP:0002754)2.46748044
44Leukocytosis (HP:0001974)2.46672972
45Inflammation of the large intestine (HP:0002037)2.44521710
46Increased cerebral lipofuscin (HP:0011813)2.43618900
47* Epistaxis (HP:0000421)2.41060848
48Viral hepatitis (HP:0006562)2.40144927
49Submucous cleft hard palate (HP:0000176)2.39650490
50Myocardial infarction (HP:0001658)2.35816684
51Retrobulbar optic neuritis (HP:0100654)2.35132774
52Optic neuritis (HP:0100653)2.35132774
53Anorexia (HP:0002039)2.33740425
54Narrow palate (HP:0000189)2.32592153
55T lymphocytopenia (HP:0005403)2.32344784
56Hypochromic microcytic anemia (HP:0004840)2.30959818
57Autoimmune hemolytic anemia (HP:0001890)2.30933004
58Premature loss of primary teeth (HP:0006323)2.30357998
59Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.29387860
60Urethral obstruction (HP:0000796)2.26902927
61Increased IgE level (HP:0003212)2.26813121
62Acute hepatic failure (HP:0006554)2.26004781
63Episodic fever (HP:0001954)2.25577783
64Macroorchidism (HP:0000053)2.23974715
65Postural instability (HP:0002172)2.23840430
66Gastrointestinal inflammation (HP:0004386)2.21791739
67Abnormality of T cell number (HP:0011839)2.20980854
68Amyloidosis (HP:0011034)2.20594012
69Distal lower limb amyotrophy (HP:0008944)2.18399958
70Heterotopia (HP:0002282)2.17996916
71Abnormality of the frontal sinuses (HP:0002687)2.17654072
72Abnormality of T cell physiology (HP:0011840)2.17316507
73Orchitis (HP:0100796)2.14823558
74Cellulitis (HP:0100658)2.14600784
75Pulmonary infiltrates (HP:0002113)2.13995473
76Meningitis (HP:0001287)2.13969366
77Large earlobe (HP:0009748)2.10837354
78Papillary thyroid carcinoma (HP:0002895)2.10789027
79Fatigue (HP:0012378)2.10352452
80Abnormality of the endocardium (HP:0004306)2.09336368
81Long toe (HP:0010511)2.07648422
82Granulocytopenia (HP:0001913)2.06904802
83Joint hemorrhage (HP:0005261)2.06604536
84* Periodontitis (HP:0000704)2.06158333
85Prolonged bleeding time (HP:0003010)2.05808823
86Abnormality of the pleura (HP:0002103)2.05425134
87Obstructive lung disease (HP:0006536)2.04942763
88Chronic obstructive pulmonary disease (HP:0006510)2.04942763
89Pustule (HP:0200039)2.04652607
90Arterial thrombosis (HP:0004420)2.04045046
91Abnormality of the peritoneum (HP:0002585)2.03576537
92Panhypogammaglobulinemia (HP:0003139)2.03392305
93Sepsis (HP:0100806)2.03291273
94Keratitis (HP:0000491)2.02987157
95Hypochromic anemia (HP:0001931)2.02272071
96Progressive hearing impairment (HP:0001730)2.02206611
97Slow saccadic eye movements (HP:0000514)2.00070568
98Amaurosis fugax (HP:0100576)1.99967877
99* Ocular albinism (HP:0001107)1.98931526
100Restrictive lung disease (HP:0002091)1.98714216
101Microcytic anemia (HP:0001935)1.98695586
102Frequent falls (HP:0002359)1.96550529
103Abnormality of the thoracic spine (HP:0100711)1.95414755
104Abnormality of the vasculature of the conjunctiva (HP:0008054)1.95388200
105Vertigo (HP:0002321)1.94497336
106Resting tremor (HP:0002322)1.94096636
107Hypoplasia of the thymus (HP:0000778)1.93879540
108Upper motor neuron abnormality (HP:0002127)1.93791448
109Generalized hypopigmentation of hair (HP:0011358)1.93046952
110Progressive sensorineural hearing impairment (HP:0000408)1.91889018
111Increased neuronal autofluorescent lipopigment (HP:0002074)1.91883200
112Vacuolated lymphocytes (HP:0001922)1.91308311
113Papilledema (HP:0001085)1.90863052
114Agammaglobulinemia (HP:0004432)1.90243721
115Glomerulopathy (HP:0100820)1.89865711
116Conjunctival telangiectasia (HP:0000524)1.88581428
117Neoplasm of the tracheobronchial system (HP:0100552)1.88391704
118Visual hallucinations (HP:0002367)1.87636717
119Lower limb amyotrophy (HP:0007210)1.87234295
120Lymphopenia (HP:0001888)1.86729988
121Thrombophlebitis (HP:0004418)1.86646670
122Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86558858
123Abnormality of polysaccharide metabolism (HP:0011012)1.86558858
124Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86558858
125Cheilitis (HP:0100825)1.86107812
126Disinhibition (HP:0000734)1.85198819
127Coarse hair (HP:0002208)1.83844152
128Abnormality of eosinophils (HP:0001879)1.83680866
129Abnormality of vision evoked potentials (HP:0000649)1.83070616
130Abnormality of the columella (HP:0009929)1.82738724
131Widely spaced teeth (HP:0000687)1.82718899
132Syringomyelia (HP:0003396)1.81366471
133Spinal cord lesions (HP:0100561)1.81366471
134Increased CSF protein (HP:0002922)1.80619160
135Inappropriate behavior (HP:0000719)1.80353361
136Pathologic fracture (HP:0002756)1.79881884
137Hemiplegia (HP:0002301)1.79358327
138Abnormality of cells of the lymphoid lineage (HP:0012140)1.79052023
139Lip pit (HP:0100267)1.78945262
140Volvulus (HP:0002580)1.78825552
141Mitral stenosis (HP:0001718)1.78141754
142Abnormality of glycolipid metabolism (HP:0010969)1.77833481
143Abnormality of liposaccharide metabolism (HP:0010968)1.77833481
144Abnormality of glycosphingolipid metabolism (HP:0004343)1.77833481
145Abnormal platelet volume (HP:0011876)1.77723757
146Polyneuropathy (HP:0001271)1.77402579
147Global brain atrophy (HP:0002283)1.77266411
148Impaired platelet aggregation (HP:0003540)1.77048837
149Abnormal platelet function (HP:0011869)1.77048837
150Albinism (HP:0001022)1.76899460
151Joint swelling (HP:0001386)1.75987884
152Chronic diarrhea (HP:0002028)1.75322467
153Increased IgM level (HP:0003496)1.73828155

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K133.37012944
2RIPK43.33326263
3MAP3K143.23375528
4TAOK33.04455801
5CAMK1D2.55686102
6CAMK1G2.55233631
7MAP4K12.51218305
8TYK22.41838612
9SIK22.40634498
10CDK122.36572757
11IRAK42.34897176
12KIT2.26406048
13JAK12.20356185
14IRAK31.94575774
15IKBKE1.82466105
16JAK31.75565185
17PIK3CG1.75406404
18FES1.73268487
19TTN1.72496652
20TXK1.71767240
21MAP3K21.67763608
22BMPR21.66883609
23SGK21.64509466
24HCK1.61221292
25SGK31.61020049
26BRD41.60589199
27DAPK21.57267357
28IKBKB1.53646901
29CSF1R1.52926627
30IRAK11.41546578
31PTK2B1.37884605
32CAMKK21.35572756
33PTK61.35298355
34TBK11.34878598
35MAP3K31.31779205
36RIPK11.28496314
37CHUK1.26508484
38SYK1.24927841
39EPHB11.22683629
40FGFR31.20379428
41ZAP701.19577300
42CSK1.14811710
43TNK21.14719936
44CDK61.13666903
45IRAK21.10944320
46MAP3K11.08930573
47ITK1.03064839
48KSR21.01507052
49KSR10.98628241
50LCK0.97842011
51MARK30.94354581
52SGK10.92820245
53NLK0.92333084
54JAK20.91687917
55MATK0.91672755
56PRKAA20.90873113
57BTK0.88252451
58INSRR0.88167055
59TEC0.87327677
60TAOK10.86905387
61MAP2K30.84343689
62SGK2230.81478322
63SGK4940.81478322
64TRPM70.79817758
65PDK10.79746825
66GRK50.79162290
67LRRK20.79039814
68FGFR40.78110800
69NEK90.77859438
70PDGFRB0.76104792
71CAMKK10.75457457
72FGR0.73904840
73MAP3K70.71904248
74RPS6KA20.71527969
75MAPK70.70247538
76EPHA30.70224298
77HIPK20.68355710
78PRKCH0.67936923
79MAP3K100.67872499
80RAF10.67522507
81WNK10.67037011
82PDPK10.65861889
83STK380.65839167
84MAP3K110.65176319
85GRK60.64784010
86ACVR1B0.64663978
87MAP3K50.64417958
88CDK90.64334468
89ERBB20.63693378
90PAK30.63284318
91SIK10.62631697
92MAP3K90.60801942
93LYN0.60643290
94EGFR0.60572969
95MTOR0.59776694
96MAP2K40.59452415
97PRPF4B0.59381671
98ERN10.59174822
99MELK0.58157150
100PKN10.57739287
101RET0.57219506
102CDK190.56557162
103MAPK120.55306053
104BLK0.54764848
105CAMK40.54433932
106NEK60.52070104
107DYRK1A0.51616769
108PIM10.51470343
109STK100.50252001
110DAPK10.49976801
111ATR0.49928710
112YES10.49718049
113NUAK10.49610752
114FYN0.48952174
115SCYL20.48630395
116MARK20.48110589
117MAP2K60.47511077
118SIK30.46969435
119PRKCQ0.46775848
120STK110.46515599
121ABL10.45970421
122FRK0.45452269
123FLT30.44614551
124TGFBR20.44555095
125RPS6KA60.43326200
126STK40.43107085
127RPS6KL10.42690731
128RPS6KC10.42690731
129RPS6KA40.42276192
130MAPK100.41660607
131MAP3K60.40779377
132PLK20.40445173

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.39532002
2Osteoclast differentiation_Homo sapiens_hsa043802.29660978
3Caffeine metabolism_Homo sapiens_hsa002322.25754573
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.21348783
5Leishmaniasis_Homo sapiens_hsa051402.06148011
6NOD-like receptor signaling pathway_Homo sapiens_hsa046212.01718610
7Type II diabetes mellitus_Homo sapiens_hsa049301.79639051
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.73149047
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.72230028
10Autoimmune thyroid disease_Homo sapiens_hsa053201.62831735
11Staphylococcus aureus infection_Homo sapiens_hsa051501.61030863
12Lysine degradation_Homo sapiens_hsa003101.58570821
13Phosphatidylinositol signaling system_Homo sapiens_hsa040701.58330052
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.56932825
15Tuberculosis_Homo sapiens_hsa051521.52769992
16Measles_Homo sapiens_hsa051621.51277824
17T cell receptor signaling pathway_Homo sapiens_hsa046601.46833012
18Primary immunodeficiency_Homo sapiens_hsa053401.45959206
19Chemokine signaling pathway_Homo sapiens_hsa040621.41748138
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40109328
21TNF signaling pathway_Homo sapiens_hsa046681.39360222
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38876986
23Chronic myeloid leukemia_Homo sapiens_hsa052201.35508383
24Influenza A_Homo sapiens_hsa051641.34323692
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33905978
26mTOR signaling pathway_Homo sapiens_hsa041501.26999406
27Toxoplasmosis_Homo sapiens_hsa051451.26103867
28Hematopoietic cell lineage_Homo sapiens_hsa046401.21661961
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.20069513
30Type I diabetes mellitus_Homo sapiens_hsa049401.20065185
31Inositol phosphate metabolism_Homo sapiens_hsa005621.17454242
32Acute myeloid leukemia_Homo sapiens_hsa052211.15207784
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.11611606
34ABC transporters_Homo sapiens_hsa020101.11303980
35Apoptosis_Homo sapiens_hsa042101.09256789
36Malaria_Homo sapiens_hsa051441.08872654
37Insulin resistance_Homo sapiens_hsa049311.07617912
38Pancreatic cancer_Homo sapiens_hsa052121.07171957
39Pertussis_Homo sapiens_hsa051331.05772128
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.03669592
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03342677
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.02924087
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.02102047
44Hepatitis C_Homo sapiens_hsa051601.01245063
45Renal cell carcinoma_Homo sapiens_hsa052111.01188538
46Lysosome_Homo sapiens_hsa041421.01091844
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98222778
48Hepatitis B_Homo sapiens_hsa051610.98063683
49Platelet activation_Homo sapiens_hsa046110.98012495
50Asthma_Homo sapiens_hsa053100.96609801
51Dorso-ventral axis formation_Homo sapiens_hsa043200.95004851
52Non-small cell lung cancer_Homo sapiens_hsa052230.93860497
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.92804388
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86091973
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85972349
56Glioma_Homo sapiens_hsa052140.85134812
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83800336
58Small cell lung cancer_Homo sapiens_hsa052220.82476650
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79029543
60African trypanosomiasis_Homo sapiens_hsa051430.78687080
61MicroRNAs in cancer_Homo sapiens_hsa052060.78491110
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78042984
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.77489822
64Nitrogen metabolism_Homo sapiens_hsa009100.77350035
65Prolactin signaling pathway_Homo sapiens_hsa049170.76780303
66Allograft rejection_Homo sapiens_hsa053300.76455689
67Herpes simplex infection_Homo sapiens_hsa051680.75531220
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75040109
69Olfactory transduction_Homo sapiens_hsa047400.74370926
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73944210
71Rheumatoid arthritis_Homo sapiens_hsa053230.73513130
72Graft-versus-host disease_Homo sapiens_hsa053320.72049648
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.71785027
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71444405
75FoxO signaling pathway_Homo sapiens_hsa040680.70293636
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70204515
77Phagosome_Homo sapiens_hsa041450.69618413
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69488048
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68848674
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68637550
81Viral myocarditis_Homo sapiens_hsa054160.68015128
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67241853
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67182546
84Choline metabolism in cancer_Homo sapiens_hsa052310.66375627
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64770322
86Viral carcinogenesis_Homo sapiens_hsa052030.64097284
87Shigellosis_Homo sapiens_hsa051310.63695377
88Insulin signaling pathway_Homo sapiens_hsa049100.62433567
89Long-term potentiation_Homo sapiens_hsa047200.61535451
90Complement and coagulation cascades_Homo sapiens_hsa046100.61301558
91Regulation of autophagy_Homo sapiens_hsa041400.61284121
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.59958199
93Legionellosis_Homo sapiens_hsa051340.59821861
94Colorectal cancer_Homo sapiens_hsa052100.59688484
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58857258
96HIF-1 signaling pathway_Homo sapiens_hsa040660.57576215
97VEGF signaling pathway_Homo sapiens_hsa043700.56643274
98Collecting duct acid secretion_Homo sapiens_hsa049660.54827287
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53695762
100Antigen processing and presentation_Homo sapiens_hsa046120.53112260
101Salmonella infection_Homo sapiens_hsa051320.51883101
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51817300
103Morphine addiction_Homo sapiens_hsa050320.51715747
104MAPK signaling pathway_Homo sapiens_hsa040100.51400842
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50884149
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50495122
107Prostate cancer_Homo sapiens_hsa052150.50491755
108Proteoglycans in cancer_Homo sapiens_hsa052050.50425630
109Epstein-Barr virus infection_Homo sapiens_hsa051690.49519461
110GnRH signaling pathway_Homo sapiens_hsa049120.49278802
111Amoebiasis_Homo sapiens_hsa051460.49180328
112ErbB signaling pathway_Homo sapiens_hsa040120.48342216
113Cholinergic synapse_Homo sapiens_hsa047250.47875704
114Estrogen signaling pathway_Homo sapiens_hsa049150.47842520
115Endometrial cancer_Homo sapiens_hsa052130.47631868
116Other glycan degradation_Homo sapiens_hsa005110.47333272
117Notch signaling pathway_Homo sapiens_hsa043300.46298409
118Endocytosis_Homo sapiens_hsa041440.45868751

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