LYZ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.26495985
2response to peptidoglycan (GO:0032494)6.26473377
3positive regulation of gamma-delta T cell activation (GO:0046645)6.21247665
4detection of other organism (GO:0098543)5.65143869
5positive regulation by symbiont of host defense response (GO:0052509)5.62523181
6modulation by symbiont of host defense response (GO:0052031)5.62523181
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.62523181
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.62523181
9positive regulation by organism of defense response of other organism involved in symbiotic interact5.62523181
10modulation by symbiont of host immune response (GO:0052553)5.62523181
11detection of bacterium (GO:0016045)5.27326937
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.22913353
13negative regulation of cell killing (GO:0031342)5.22913353
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.22403239
15cellular extravasation (GO:0045123)5.17507687
16macrophage activation involved in immune response (GO:0002281)5.01282586
17negative regulation of interleukin-12 production (GO:0032695)4.66797255
18detection of external biotic stimulus (GO:0098581)4.64454025
19antigen processing and presentation of endogenous antigen (GO:0019883)4.61641021
20positive regulation of mast cell activation (GO:0033005)4.53453819
21detection of molecule of bacterial origin (GO:0032490)4.53228682
22microglial cell activation (GO:0001774)4.48827287
23regulation of B cell receptor signaling pathway (GO:0050855)4.43184805
24regulation of mast cell degranulation (GO:0043304)4.39660826
25respiratory burst (GO:0045730)4.39455599
26neutrophil mediated immunity (GO:0002446)4.39147949
27regulation of gamma-delta T cell activation (GO:0046643)4.37162486
28immunoglobulin mediated immune response (GO:0016064)4.36134246
29detection of biotic stimulus (GO:0009595)4.28673136
30neutrophil activation (GO:0042119)4.25568706
31positive regulation of mast cell degranulation (GO:0043306)4.11132028
32positive regulation of mast cell activation involved in immune response (GO:0033008)4.11132028
33regulation of myeloid leukocyte mediated immunity (GO:0002886)4.10423422
34macrophage activation (GO:0042116)4.06478100
35regulation of mast cell activation involved in immune response (GO:0033006)4.05697006
36positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.00461948
37myeloid cell activation involved in immune response (GO:0002275)3.97902596
38regulation of mast cell activation (GO:0033003)3.97692480
39response to muramyl dipeptide (GO:0032495)3.96181935
40regulation of interferon-beta biosynthetic process (GO:0045357)3.93970330
41response to host immune response (GO:0052572)3.93200757
42response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.93200757
43granulocyte activation (GO:0036230)3.92208090
44regulation of leukocyte degranulation (GO:0043300)3.91898769
45antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.88558383
46leukocyte aggregation (GO:0070486)3.76876369
47positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.74746680
48antigen processing and presentation via MHC class Ib (GO:0002475)3.72984549
49myeloid leukocyte mediated immunity (GO:0002444)3.71696196
50negative regulation of lymphocyte mediated immunity (GO:0002707)3.70160673
51negative regulation of T cell mediated immunity (GO:0002710)3.66676988
52positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.61950834
53response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.60513047
54response to host (GO:0075136)3.60513047
55response to host defenses (GO:0052200)3.60513047
56negative regulation of erythrocyte differentiation (GO:0045647)3.57532835
57regulation of gamma-delta T cell differentiation (GO:0045586)3.57325234
58antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.55522567
59positive regulation of B cell differentiation (GO:0045579)3.48907165
60regulation of tolerance induction (GO:0002643)3.47404638
61positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.46861333
62positive regulation of cellular amide metabolic process (GO:0034250)3.42683875
63regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.40988531
64regulation of regulated secretory pathway (GO:1903305)3.40345273
65leukocyte migration involved in inflammatory response (GO:0002523)3.35998326
66B cell mediated immunity (GO:0019724)3.35196203
67negative regulation of leukocyte mediated immunity (GO:0002704)3.33078329
68regulation of interleukin-8 biosynthetic process (GO:0045414)3.31892491
69lipopolysaccharide-mediated signaling pathway (GO:0031663)3.25855671
70positive regulation of leukocyte degranulation (GO:0043302)3.23357806
71regulation of B cell differentiation (GO:0045577)3.21878704
72leukocyte degranulation (GO:0043299)3.21821334
73positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.21296178
74B cell receptor signaling pathway (GO:0050853)3.18406674
75interferon-gamma-mediated signaling pathway (GO:0060333)3.12005488
76regulation of T cell tolerance induction (GO:0002664)3.11943504
77regulation of dendritic cell antigen processing and presentation (GO:0002604)3.09866765
78modulation of growth of symbiont involved in interaction with host (GO:0044144)3.07877054
79regulation of growth of symbiont in host (GO:0044126)3.07877054
80negative regulation of growth of symbiont in host (GO:0044130)3.07877054
81negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.07877054
82production of molecular mediator involved in inflammatory response (GO:0002532)3.07734408
83defense response to protozoan (GO:0042832)3.05010430
84positive regulation of regulated secretory pathway (GO:1903307)3.03428832
85positive thymic T cell selection (GO:0045059)3.02481627
86myeloid leukocyte activation (GO:0002274)2.96999430
87positive regulation of interferon-alpha production (GO:0032727)2.95510856
88positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.90631328
89activated T cell proliferation (GO:0050798)2.90494342
90regulation of macrophage cytokine production (GO:0010935)2.90306195
91regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.89161227
92negative regulation of interleukin-8 production (GO:0032717)2.87521654
93negative regulation of interleukin-6 production (GO:0032715)2.86348529
94regulation of antigen processing and presentation (GO:0002577)2.83470364
95positive regulation of antigen processing and presentation (GO:0002579)2.82958810
96T cell migration (GO:0072678)2.82042608
97positive regulation of tolerance induction (GO:0002645)2.79845696
98regulation of interferon-alpha production (GO:0032647)2.79204603
99neutrophil chemotaxis (GO:0030593)2.78689083
100response to fungus (GO:0009620)2.77659429

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.72672398
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.99172214
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.47916994
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.83362504
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.71045027
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.64548378
7MYB_21317192_ChIP-Seq_ERMYB_Mouse3.36640446
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.35949234
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.22177412
10VDR_21846776_ChIP-Seq_THP-1_Human3.13772074
11VDR_24763502_ChIP-Seq_THP-1_Human3.12887929
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.04553821
13* SPI1_23547873_ChIP-Seq_NB4_Human2.99205508
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.79089139
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.70081202
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.65037483
17SPI1_23127762_ChIP-Seq_K562_Human2.54236085
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.53342666
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.48449165
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.47125574
21SCL_19346495_ChIP-Seq_HPC-7_Human2.45462325
22RUNX_20019798_ChIP-Seq_JUKART_Human2.42459206
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.42396751
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.39663410
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.33729928
26MYB_26560356_Chip-Seq_TH2_Human2.29359508
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.29267010
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.28973929
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.27308518
30VDR_24787735_ChIP-Seq_THP-1_Human2.26536056
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.17131775
32MAF_26560356_Chip-Seq_TH1_Human2.15290565
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.11684139
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.93045537
35UTX_26944678_Chip-Seq_JUKART_Human1.89203547
36MYB_26560356_Chip-Seq_TH1_Human1.88431178
37* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.84719908
38MYC_22102868_ChIP-Seq_BL_Human1.84694804
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80497292
40CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.75723037
41TCF7_22412390_ChIP-Seq_EML_Mouse1.74347805
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72199381
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60444167
44PU_27001747_Chip-Seq_BMDM_Mouse1.57479890
45GATA3_27048872_Chip-Seq_THYMUS_Human1.56679699
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56315925
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.54561819
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52397319
49PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46708495
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.46618816
51CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.45438621
52CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44954757
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44331566
54CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.44139451
55PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.43666982
56PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42512147
57MAF_26560356_Chip-Seq_TH2_Human1.40734788
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.40326634
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38962519
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38182099
61KDM2B_26808549_Chip-Seq_DND41_Human1.36586634
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36569883
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36468122
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34997115
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.31557731
66GATA3_26560356_Chip-Seq_TH2_Human1.30015337
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29206688
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28365750
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24886459
70SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20492281
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17444217
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17396484
73GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14070389
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12642769
75GATA1_19941826_ChIP-Seq_K562_Human1.11089197
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09876812
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09578588
78GATA1_22025678_ChIP-Seq_K562_Human1.07923047
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07501493
80PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03982488
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02734528
82ELK3_25401928_ChIP-Seq_HUVEC_Human1.02657482
83LXR_22292898_ChIP-Seq_THP-1_Human1.01563351
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99104191
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96735838
86GATA2_19941826_ChIP-Seq_K562_Human0.92251632
87RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91794044
88VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91667997
89TFEB_21752829_ChIP-Seq_HELA_Human0.90638627
90KDM2B_26808549_Chip-Seq_JURKAT_Human0.89294288
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84748782
92BCL6_27268052_Chip-Seq_Bcells_Human0.83117094
93SPI1_20517297_ChIP-Seq_HL60_Human0.83001711
94BCOR_27268052_Chip-Seq_Bcells_Human0.81009576
95PPARA_22158963_ChIP-Seq_LIVER_Mouse0.80402381
96* NCOR1_26117541_ChIP-Seq_K562_Human0.80124941
97* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.78004622
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75811314
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75588049
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.75584265

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.16942248
2MP0001835_abnormal_antigen_presentation4.13722836
3MP0003436_decreased_susceptibility_to4.02628462
4MP0003303_peritoneal_inflammation3.56052203
5MP0002419_abnormal_innate_immunity3.34082020
6MP0006082_CNS_inflammation3.15181784
7MP0005025_abnormal_response_to2.93182691
8MP0009785_altered_susceptibility_to2.90363600
9MP0003172_abnormal_lysosome_physiology2.82273320
10MP0001800_abnormal_humoral_immune2.71974584
11MP0005671_abnormal_response_to2.69482426
12MP0005000_abnormal_immune_tolerance2.68341839
13MP0000685_abnormal_immune_system2.66569418
14MP0002452_abnormal_antigen_presenting2.50777276
15MP0005058_abnormal_lysosome_morphology2.48708647
16MP0002723_abnormal_immune_serum2.43302347
17MP0001790_abnormal_immune_system2.43092881
18MP0005387_immune_system_phenotype2.43092881
19MP0002148_abnormal_hypersensitivity_rea2.41943851
20MP0002420_abnormal_adaptive_immunity2.38753618
21MP0001819_abnormal_immune_cell2.36103542
22MP0003828_pulmonary_edema2.32260493
23MP0005464_abnormal_platelet_physiology2.24171942
24MP0003191_abnormal_cellular_cholesterol2.10966663
25MP0003300_gastrointestinal_ulcer2.10874059
26MP0008260_abnormal_autophagy2.03985154
27MP0001533_abnormal_skeleton_physiology2.03019894
28MP0001845_abnormal_inflammatory_respons1.79344023
29MP0002166_altered_tumor_susceptibility1.76804959
30MP0002405_respiratory_system_inflammati1.76470671
31MP0009278_abnormal_bone_marrow1.74734300
32MP0000716_abnormal_immune_system1.73270294
33MP0010155_abnormal_intestine_physiology1.70878503
34MP0002398_abnormal_bone_marrow1.69539358
35MP0002132_abnormal_respiratory_system1.68373533
36MP0002009_preneoplasia1.61211272
37MP0004947_skin_inflammation1.61135870
38MP0003763_abnormal_thymus_physiology1.59938832
39MP0004883_abnormal_blood_vessel1.58847887
40MP0003075_altered_response_to1.57838093
41MP0009764_decreased_sensitivity_to1.57153955
42MP0001853_heart_inflammation1.53632079
43MP0000465_gastrointestinal_hemorrhage1.53038686
44MP0008469_abnormal_protein_level1.50739016
45MP0005397_hematopoietic_system_phenotyp1.49285193
46MP0001545_abnormal_hematopoietic_system1.49285193
47MP0000689_abnormal_spleen_morphology1.47861765
48MP0003690_abnormal_glial_cell1.47841389
49MP0002998_abnormal_bone_remodeling1.45532092
50MP0002722_abnormal_immune_system1.42601992
51MP0000858_altered_metastatic_potential1.42169848
52MP0009333_abnormal_splenocyte_physiolog1.42048417
53MP0002429_abnormal_blood_cell1.37869555
54MP0001851_eye_inflammation1.32748886
55MP0003866_abnormal_defecation1.31808442
56MP0003183_abnormal_peptide_metabolism1.30736886
57MP0000569_abnormal_digit_pigmentation1.28605092
58MP0003656_abnormal_erythrocyte_physiolo1.26560289
59MP0000604_amyloidosis1.25327191
60MP0005164_abnormal_response_to1.25102901
61MP0005166_decreased_susceptibility_to1.24884229
62MP0003806_abnormal_nucleotide_metabolis1.23808865
63MP0002396_abnormal_hematopoietic_system1.22682745
64MP0005310_abnormal_salivary_gland1.16673118
65MP0002006_tumorigenesis1.13028786
66MP0005451_abnormal_body_composition1.12790586
67MP0000703_abnormal_thymus_morphology1.08738803
68MP0000343_altered_response_to1.04440274
69MP0008004_abnormal_stomach_pH1.00155953
70MP0000015_abnormal_ear_pigmentation0.99748649
71MP0003448_altered_tumor_morphology0.95696836
72MP0009763_increased_sensitivity_to0.91324484
73MP0004381_abnormal_hair_follicle0.90515219
74MP0009840_abnormal_foam_cell0.82845170
75MP0005390_skeleton_phenotype0.80239461
76MP0001663_abnormal_digestive_system0.79271083
77MP0005075_abnormal_melanosome_morpholog0.78933458
78MP0004510_myositis0.78885484
79MP0004808_abnormal_hematopoietic_stem0.77385251
80MP0005360_urolithiasis0.77221112
81MP0005076_abnormal_cell_differentiation0.73129084
82MP0001986_abnormal_taste_sensitivity0.72865130
83MP0002277_abnormal_respiratory_mucosa0.72364507
84MP0000249_abnormal_blood_vessel0.71433713
85MP0003795_abnormal_bone_structure0.70845201
86MP0005174_abnormal_tail_pigmentation0.62930750
87MP0002933_joint_inflammation0.62221699
88MP0003329_amyloid_beta_deposits0.61173369
89MP0009765_abnormal_xenobiotic_induced0.60961320
90MP0005319_abnormal_enzyme/_coenzyme0.59464650
91MP0005388_respiratory_system_phenotype0.57124337
92MP0002133_abnormal_respiratory_system0.57124337
93MP0000920_abnormal_myelination0.57049070
94MP0001873_stomach_inflammation0.56846683
95MP0003091_abnormal_cell_migration0.54831459
96MP0006054_spinal_hemorrhage0.54113480
97MP0000490_abnormal_crypts_of0.53344356
98MP0000609_abnormal_liver_physiology0.52332244
99MP0005376_homeostasis/metabolism_phenot0.52237477
100MP0005167_abnormal_blood-brain_barrier0.50316518

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)6.46727610
2Eczematoid dermatitis (HP:0000976)6.41528255
3Recurrent abscess formation (HP:0002722)6.28671612
4Abnormality of macrophages (HP:0004311)5.85421165
5Recurrent gram-negative bacterial infections (HP:0005420)5.36447458
6Myositis (HP:0100614)5.32637090
7Orchitis (HP:0100796)4.79267929
8Elevated erythrocyte sedimentation rate (HP:0003565)4.73734666
9Retrobulbar optic neuritis (HP:0100654)4.71501206
10Optic neuritis (HP:0100653)4.71501206
11Stomatitis (HP:0010280)4.43996383
12Recurrent skin infections (HP:0001581)4.32278855
13Obstructive lung disease (HP:0006536)4.27615201
14Chronic obstructive pulmonary disease (HP:0006510)4.27615201
15Recurrent fungal infections (HP:0002841)4.16493740
16Mediastinal lymphadenopathy (HP:0100721)4.08039452
17Gastrointestinal infarctions (HP:0005244)3.90070997
18Chronic mucocutaneous candidiasis (HP:0002728)3.85634813
19Recurrent cutaneous fungal infections (HP:0011370)3.85634813
20Meningitis (HP:0001287)3.74506685
21Abnormality of glycolipid metabolism (HP:0010969)3.67218930
22Abnormality of liposaccharide metabolism (HP:0010968)3.67218930
23Abnormality of glycosphingolipid metabolism (HP:0004343)3.67218930
24Gingivitis (HP:0000230)3.54255107
25Increased cerebral lipofuscin (HP:0011813)3.44601367
26Keratoconjunctivitis sicca (HP:0001097)3.44390262
27Urticaria (HP:0001025)3.40293761
28Hemoptysis (HP:0002105)3.31927096
29Vasculitis (HP:0002633)3.30245202
30Abnormal delayed hypersensitivity skin test (HP:0002963)3.25148013
31Pulmonary infiltrates (HP:0002113)3.23319799
32Keratoconjunctivitis (HP:0001096)3.22427546
33Encephalitis (HP:0002383)3.15874950
34Chest pain (HP:0100749)3.14407192
35* Amyloidosis (HP:0011034)3.04913155
36Prolonged bleeding time (HP:0003010)3.00539616
37Gingival bleeding (HP:0000225)2.99885221
38Recurrent viral infections (HP:0004429)2.97864376
39Spontaneous hematomas (HP:0007420)2.96531948
40Arterial thrombosis (HP:0004420)2.95077977
41Episodic fever (HP:0001954)2.86542121
42Leukocytosis (HP:0001974)2.81852293
43Epistaxis (HP:0000421)2.81133635
44Dysostosis multiplex (HP:0000943)2.80753131
45Increased neuronal autofluorescent lipopigment (HP:0002074)2.74212991
46Cellulitis (HP:0100658)2.74100609
47Pulmonary embolism (HP:0002204)2.70989117
48Increased IgE level (HP:0003212)2.68855043
49Vacuolated lymphocytes (HP:0001922)2.62667485
50Thrombocytosis (HP:0001894)2.61488739
51T lymphocytopenia (HP:0005403)2.56945795
52Loss of speech (HP:0002371)2.52833949
53Gangrene (HP:0100758)2.52424018
54Abnormality of T cell number (HP:0011839)2.46728241
55Systemic lupus erythematosus (HP:0002725)2.44997140
56Increased serum ferritin (HP:0003281)2.44870129
57Petechiae (HP:0000967)2.43407176
58Anorexia (HP:0002039)2.43272225
59Purpura (HP:0000979)2.43083833
60Peritonitis (HP:0002586)2.43029572
61Osteomyelitis (HP:0002754)2.41070424
62Pustule (HP:0200039)2.41056754
63Abnormality of the pleura (HP:0002103)2.40137189
64Granulocytopenia (HP:0001913)2.35949821
65Inflammation of the large intestine (HP:0002037)2.35867510
66Glomerulopathy (HP:0100820)2.30304261
67Gastrointestinal inflammation (HP:0004386)2.24939318
68Abnormality of T cells (HP:0002843)2.22847921
69Hepatosplenomegaly (HP:0001433)2.20212717
70Amaurosis fugax (HP:0100576)2.19921360
71Vertigo (HP:0002321)2.19329109
72Autoimmune thrombocytopenia (HP:0001973)2.18865591
73Polyneuropathy (HP:0001271)2.16041824
74Myocardial infarction (HP:0001658)2.14448375
75Abnormality of iron homeostasis (HP:0011031)2.13172196
76Disinhibition (HP:0000734)2.12502262
77Colitis (HP:0002583)2.11336611
78Cheilitis (HP:0100825)2.10650872
79Panhypogammaglobulinemia (HP:0003139)2.10307450
80Fatigue (HP:0012378)2.09485230
81Thrombophlebitis (HP:0004418)2.09292193
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06066441
83Abnormality of polysaccharide metabolism (HP:0011012)2.06066441
84Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06066441
85Urinary glycosaminoglycan excretion (HP:0003541)2.01744789
86Mucopolysacchariduria (HP:0008155)2.01744789
87Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01621266
88Skin ulcer (HP:0200042)2.01534759
89Abnormality of the peritoneum (HP:0002585)1.99776279
90Sepsis (HP:0100806)1.98501227
91Abnormality of T cell physiology (HP:0011840)1.97831989
92Abnormality of the prostate (HP:0008775)1.97059139
93Abnormality of the endocardium (HP:0004306)1.96168298
94Hypergammaglobulinemia (HP:0010702)1.95600718
95Malnutrition (HP:0004395)1.95067199
96Periodontitis (HP:0000704)1.92706284
97Increased IgM level (HP:0003496)1.91190195
98Hypochromic anemia (HP:0001931)1.89421823
99Eosinophilia (HP:0001880)1.86523961
100Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84798817

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.30916505
2BLK3.64980684
3TYK23.18431113
4MAP2K33.10916332
5FES3.06308580
6MAP4K12.82179356
7CSK2.67980123
8PRPF4B2.64485942
9IRAK42.46570934
10ZAP702.29955581
11MAP3K142.20676690
12GRK62.05627357
13FGR1.99389259
14ERN11.96588094
15SYK1.95064821
16BTK1.94193781
17CSF1R1.76952099
18BMPR21.74974652
19MAP3K131.73898636
20MAP3K31.72173576
21JAK31.70875128
22TNK21.66976085
23TEC1.60867989
24HCK1.60787279
25KIT1.59405696
26LYN1.50860486
27TBK11.49361578
28TXK1.47496493
29IKBKE1.41105618
30JAK21.38676256
31JAK11.36151229
32ITK1.31763617
33TAOK31.30446704
34CDK191.29511778
35MAP3K11.25891475
36TAOK11.24909834
37LCK1.17130091
38YES11.14925456
39MATK1.13375487
40MAP3K111.05649434
41PIK3CG1.04523183
42MAP3K61.03884547
43IKBKB1.03671476
44PDK11.02963058
45KSR20.99166949
46IRAK20.97849001
47PDPK10.96520983
48EPHB10.95193568
49TGFBR20.94500462
50MARK30.92026087
51IRAK10.86444526
52STK100.86176406
53SIK30.84161354
54MAPK120.83564537
55MAPK70.82550518
56GRK70.82239761
57MOS0.78208555
58MAP3K20.77501543
59MARK20.73076625
60TAOK20.68699011
61FGFR30.68069058
62TRIB30.66023473
63LRRK20.64434661
64CDK60.64256089
65FYN0.63484241
66IRAK30.58962048
67RPS6KC10.56092785
68RPS6KL10.56092785
69PTK60.54980653
70MAP3K70.53537056
71MAP3K50.53107945
72TRPM70.52545336
73TESK20.51301650
74MAP2K40.50128277
75SGK30.48112254
76PRKCQ0.47875813
77RPS6KA60.46308187
78CAMKK20.45672347
79CDC42BPA0.43494816
80ABL10.40961369
81MAP2K60.39889884
82STK110.39146595
83HIPK20.39140682
84MAP2K20.38461100
85PIM10.37902436
86DYRK1B0.37724484
87RET0.37080878
88PTK2B0.36867601
89MAPKAPK20.35445623
90RPS6KA40.34528817
91RAF10.34030474
92ARAF0.33077929
93PRKD20.31587964
94TTN0.30527421
95SIK20.30162955
96FGFR40.30068316
97PRKCD0.29488079
98DAPK20.28903427
99RPS6KA20.28097198
100SGK20.26981717

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.38013902
2Staphylococcus aureus infection_Homo sapiens_hsa051503.31138204
3Osteoclast differentiation_Homo sapiens_hsa043802.92992902
4Allograft rejection_Homo sapiens_hsa053302.60860648
5Graft-versus-host disease_Homo sapiens_hsa053322.57632692
6Asthma_Homo sapiens_hsa053102.57392725
7Other glycan degradation_Homo sapiens_hsa005112.57280736
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.42523639
9Autoimmune thyroid disease_Homo sapiens_hsa053202.40709760
10Tuberculosis_Homo sapiens_hsa051522.36869254
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.05936265
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.03909730
13B cell receptor signaling pathway_Homo sapiens_hsa046622.03876636
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.98428832
15Type I diabetes mellitus_Homo sapiens_hsa049401.97089475
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.94075203
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.88581590
18Antigen processing and presentation_Homo sapiens_hsa046121.85670090
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.82032612
20Legionellosis_Homo sapiens_hsa051341.79574876
21Hematopoietic cell lineage_Homo sapiens_hsa046401.73376248
22Malaria_Homo sapiens_hsa051441.68640151
23Phagosome_Homo sapiens_hsa041451.63251412
24Viral myocarditis_Homo sapiens_hsa054161.62243984
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.60448466
26Toxoplasmosis_Homo sapiens_hsa051451.60415282
27Rheumatoid arthritis_Homo sapiens_hsa053231.55583778
28Influenza A_Homo sapiens_hsa051641.54201685
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.50485845
30Lysosome_Homo sapiens_hsa041421.50233682
31Pertussis_Homo sapiens_hsa051331.47808141
32Chemokine signaling pathway_Homo sapiens_hsa040621.41759284
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.40966200
34Primary immunodeficiency_Homo sapiens_hsa053401.39593283
35Measles_Homo sapiens_hsa051621.35576792
36T cell receptor signaling pathway_Homo sapiens_hsa046601.35549931
37Acute myeloid leukemia_Homo sapiens_hsa052211.30798910
38Herpes simplex infection_Homo sapiens_hsa051681.22932407
39Platelet activation_Homo sapiens_hsa046111.14088920
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13644003
41Salmonella infection_Homo sapiens_hsa051321.12711380
42TNF signaling pathway_Homo sapiens_hsa046681.12092590
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10942853
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.10004371
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.06767246
46Hepatitis B_Homo sapiens_hsa051611.01877190
47Non-small cell lung cancer_Homo sapiens_hsa052231.00561812
48African trypanosomiasis_Homo sapiens_hsa051430.98446169
49Shigellosis_Homo sapiens_hsa051310.94360766
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78576245
51Apoptosis_Homo sapiens_hsa042100.77399027
52Pancreatic cancer_Homo sapiens_hsa052120.76356516
53Amoebiasis_Homo sapiens_hsa051460.76090776
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.75384033
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74898423
56Hepatitis C_Homo sapiens_hsa051600.74334861
57VEGF signaling pathway_Homo sapiens_hsa043700.73343414
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72685133
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71648501
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70189880
61GnRH signaling pathway_Homo sapiens_hsa049120.67650764
62Chronic myeloid leukemia_Homo sapiens_hsa052200.66037754
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.65449828
64Renal cell carcinoma_Homo sapiens_hsa052110.64656316
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64512745
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63939286
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63127533
68Prolactin signaling pathway_Homo sapiens_hsa049170.58981189
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57875526
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.56392586
71Epstein-Barr virus infection_Homo sapiens_hsa051690.56212897
72HIF-1 signaling pathway_Homo sapiens_hsa040660.56067804
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53468039
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53418668
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50576371
76Complement and coagulation cascades_Homo sapiens_hsa046100.50345676
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.49664854
78Endocytosis_Homo sapiens_hsa041440.49605818
79Dorso-ventral axis formation_Homo sapiens_hsa043200.49119870
80Choline metabolism in cancer_Homo sapiens_hsa052310.47859829
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47628655
82FoxO signaling pathway_Homo sapiens_hsa040680.46270650
83Regulation of autophagy_Homo sapiens_hsa041400.43113864
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40434042
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39510845
86Type II diabetes mellitus_Homo sapiens_hsa049300.38722221
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.38553078
88HTLV-I infection_Homo sapiens_hsa051660.38237068
89Renin-angiotensin system_Homo sapiens_hsa046140.37430071
90Insulin resistance_Homo sapiens_hsa049310.37377257
91Notch signaling pathway_Homo sapiens_hsa043300.37325808
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36196011
93Viral carcinogenesis_Homo sapiens_hsa052030.34307530
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34218300
95Endometrial cancer_Homo sapiens_hsa052130.33227021
96mTOR signaling pathway_Homo sapiens_hsa041500.32616441
97Galactose metabolism_Homo sapiens_hsa000520.32161179
98Inositol phosphate metabolism_Homo sapiens_hsa005620.31664569
99Collecting duct acid secretion_Homo sapiens_hsa049660.29927717
100Estrogen signaling pathway_Homo sapiens_hsa049150.29459403

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