LYZL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.46569148
2motile cilium assembly (GO:0044458)9.14475766
3cilium movement (GO:0003341)8.64846827
4single fertilization (GO:0007338)7.93778156
5sperm capacitation (GO:0048240)7.85939852
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.84882991
7regulation of cilium movement (GO:0003352)7.74600901
8male meiosis (GO:0007140)7.57061946
9synaptonemal complex assembly (GO:0007130)7.32239780
10synaptonemal complex organization (GO:0070193)7.24484150
11spermatid nucleus differentiation (GO:0007289)7.05395030
12piRNA metabolic process (GO:0034587)6.53789167
13fertilization (GO:0009566)6.45445194
14spermatogenesis (GO:0007283)6.18323840
15male gamete generation (GO:0048232)6.16010446
16microtubule depolymerization (GO:0007019)5.91874124
17organic cation transport (GO:0015695)5.89365264
18negative regulation of inclusion body assembly (GO:0090084)5.89151855
19gamete generation (GO:0007276)5.66832614
20calcium ion-dependent exocytosis (GO:0017156)5.55371663
21cell recognition (GO:0008037)5.43972283
22cellular process involved in reproduction in multicellular organism (GO:0022412)5.37241183
23ventricular system development (GO:0021591)5.36138601
24germ cell development (GO:0007281)5.22285193
25sexual reproduction (GO:0019953)5.14834439
26regulation of inclusion body assembly (GO:0090083)5.12837618
27microtubule severing (GO:0051013)5.11050303
28chromosome organization involved in meiosis (GO:0070192)5.02494907
29single strand break repair (GO:0000012)4.78057807
30glycerol ether metabolic process (GO:0006662)4.67938200
31regulation of microtubule-based movement (GO:0060632)4.50703670
32monoubiquitinated protein deubiquitination (GO:0035520)4.47356536
33multicellular organismal reproductive process (GO:0048609)4.45504543
34protein K11-linked deubiquitination (GO:0035871)4.39195881
35ether metabolic process (GO:0018904)4.32568363
36meiotic nuclear division (GO:0007126)4.28927782
37DNA methylation involved in gamete generation (GO:0043046)4.25607872
38male meiosis I (GO:0007141)4.18180224
39seminiferous tubule development (GO:0072520)3.97689668
40chromosome condensation (GO:0030261)3.92541389
41genitalia morphogenesis (GO:0035112)3.72042896
42protein polyglutamylation (GO:0018095)3.69043414
43DNA packaging (GO:0006323)3.66585451
44left/right pattern formation (GO:0060972)3.63562052
45chaperone-mediated protein complex assembly (GO:0051131)3.60583895
46multicellular organismal development (GO:0007275)3.57532074
47sequestering of actin monomers (GO:0042989)3.47217207
48meiosis I (GO:0007127)3.29156250
49positive regulation of macrophage activation (GO:0043032)3.21587318
50centriole assembly (GO:0098534)3.10665174
51microtubule polymerization or depolymerization (GO:0031109)3.10615351
52protein localization to cilium (GO:0061512)3.01742629
53carnitine transport (GO:0015879)3.01424990
54amino-acid betaine transport (GO:0015838)3.01424990
55glycolytic process (GO:0006096)3.01175244
56cilium organization (GO:0044782)3.01165683
57nucleus organization (GO:0006997)2.97553457
58synapsis (GO:0007129)2.92843973
59meiotic cell cycle (GO:0051321)2.92124365
60cellular component assembly involved in morphogenesis (GO:0010927)2.90811151
61intraciliary transport (GO:0042073)2.90703647
62polyol catabolic process (GO:0046174)2.90143730
63centriole replication (GO:0007099)2.89835517
64carnitine transmembrane transport (GO:1902603)2.89711418
65microtubule-based movement (GO:0007018)2.89598096
66cilium assembly (GO:0042384)2.89135113
67nucleoside diphosphate phosphorylation (GO:0006165)2.85730784
68regulation of spindle checkpoint (GO:0090231)2.85394963
69protein refolding (GO:0042026)2.83830406
70alditol metabolic process (GO:0019400)2.83507288
71lactate metabolic process (GO:0006089)2.82624599
72GTP biosynthetic process (GO:0006183)2.79785070
73meiotic cell cycle process (GO:1903046)2.67041259
74cilium morphogenesis (GO:0060271)2.64796634
75negative regulation of organelle assembly (GO:1902116)2.63312075
76regulation of centriole replication (GO:0046599)2.55182744
77axoneme assembly (GO:0035082)2.55006691
78chromatin silencing (GO:0006342)2.54527622
79interferon-gamma secretion (GO:0072643)2.54392687
80glycerol metabolic process (GO:0006071)2.50324982
81UTP biosynthetic process (GO:0006228)2.48517898
82single-organism membrane fusion (GO:0044801)2.43692374
83calcium ion import (GO:0070509)2.42339161
84peptidyl-glutamic acid modification (GO:0018200)2.41128360
85regulation of cytokine production involved in inflammatory response (GO:1900015)2.40782825
86fusion of sperm to egg plasma membrane (GO:0007342)14.7789420
87sperm motility (GO:0030317)13.5707768
88acrosome assembly (GO:0001675)13.3074633
89* cell wall macromolecule metabolic process (GO:0044036)13.0610717
90* cell wall macromolecule catabolic process (GO:0016998)13.0610717
91multicellular organism reproduction (GO:0032504)12.5298977
92sperm-egg recognition (GO:0035036)12.3892379
93acrosome reaction (GO:0007340)11.3144714
94plasma membrane fusion (GO:0045026)11.2895925
95cell-cell recognition (GO:0009988)11.1262986
96binding of sperm to zona pellucida (GO:0007339)10.9854765
97reproduction (GO:0000003)10.8895525
98epithelial cilium movement (GO:0003351)10.4823771
99cilium or flagellum-dependent cell motility (GO:0001539)10.4369409
100axonemal dynein complex assembly (GO:0070286)10.0087954

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.17506718
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.80909613
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.53627548
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.46013988
5EZH2_22144423_ChIP-Seq_EOC_Human3.22116427
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.72471390
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.65212807
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.40547261
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.39358931
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.33481825
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.28843047
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.15150328
13RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse2.09448500
14* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.05659222
15VDR_22108803_ChIP-Seq_LS180_Human2.05524659
16CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.01932968
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.99760015
18ZNF274_21170338_ChIP-Seq_K562_Hela1.94436537
19KAP1_22055183_ChIP-Seq_ESCs_Mouse1.93165318
20TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.92907142
21ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.87814746
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.84422877
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79213820
24KDM2B_26808549_Chip-Seq_REH_Human1.77132218
25GATA1_26923725_Chip-Seq_HPCs_Mouse1.75735651
26GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.73338792
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69514902
28TAL1_26923725_Chip-Seq_HPCs_Mouse1.69262056
29STAT1_17558387_ChIP-Seq_HELA_Human1.68689552
30TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.63565519
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.61902546
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59807302
33ELK4_26923725_Chip-Seq_MESODERM_Mouse1.56164486
34MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.54436291
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52811268
36CBP_20019798_ChIP-Seq_JUKART_Human1.49797181
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49797181
38GATA3_21867929_ChIP-Seq_CD8_Mouse1.49484950
39WDR5_24793694_ChIP-Seq_LNCAP_Human1.46936835
40NANOG_18555785_Chip-Seq_ESCs_Mouse1.44853051
41FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43810947
42EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42935121
43SOX2_22085726_ChIP-Seq_NPCs_Mouse1.42044609
44* FLI1_21867929_ChIP-Seq_TH2_Mouse1.39370405
45CMYC_18555785_Chip-Seq_ESCs_Mouse1.38793907
46CRX_20693478_ChIP-Seq_RETINA_Mouse1.38776255
47OCT4_18555785_Chip-Seq_ESCs_Mouse1.37991874
48GATA3_21867929_ChIP-Seq_TH1_Mouse1.37144576
49P53_22387025_ChIP-Seq_ESCs_Mouse1.34214944
50LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.33489808
51TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31553168
52P300_18555785_Chip-Seq_ESCs_Mouse1.30582213
53REST_21632747_ChIP-Seq_MESCs_Mouse1.25313278
54RNF2_27304074_Chip-Seq_NSC_Mouse1.24435145
55CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24413558
56KLF4_18555785_Chip-Seq_ESCs_Mouse1.24073336
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.22339045
58SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22109149
59EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.21779868
60ESRRB_18555785_Chip-Seq_ESCs_Mouse1.20728277
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20467861
62* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20107064
63PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17784246
64GF1_26923725_Chip-Seq_HPCs_Mouse1.17765119
65SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16839932
66STAT3_18555785_Chip-Seq_ESCs_Mouse1.16052082
67OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15967841
68RUNX1_26923725_Chip-Seq_HPCs_Mouse1.15180823
69SOX2_18555785_Chip-Seq_ESCs_Mouse1.14636829
70CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14475586
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14227755
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14227755
73TAF15_26573619_Chip-Seq_HEK293_Human1.12461883
74CTCF_18555785_Chip-Seq_ESCs_Mouse1.11057885
75KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.09860784
76* P53_21459846_ChIP-Seq_SAOS-2_Human1.09408378
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07124723
78E2F1_18555785_Chip-Seq_ESCs_Mouse1.06398175
79RUNX1_27457419_Chip-Seq_LIVER_Mouse1.06346906
80SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.05486337
81ESET_19884257_ChIP-Seq_ESCs_Mouse1.05423729
82SPI1_26923725_Chip-Seq_HPCs_Mouse1.04969343
83PU1_27457419_Chip-Seq_LIVER_Mouse1.04776706
84FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03557306
85SMAD1_18555785_Chip-Seq_ESCs_Mouse1.02668763
86NMYC_18555785_Chip-Seq_ESCs_Mouse1.02254057
87GF1B_26923725_Chip-Seq_HPCs_Mouse0.99594405
88* SOX9_26525672_Chip-Seq_HEART_Mouse0.98383751
89RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97378603
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97365408
91NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97125142
92CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94565411
93ZFX_18555785_Chip-Seq_ESCs_Mouse0.94423446
94LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93964662
95* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92588512
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90714731
97GATA1_19941827_ChIP-Seq_MEL86_Mouse0.90445458
98RARA_24833708_ChIP-Seq_LIVER_Mouse0.89949559
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89834116
100ERG_20517297_ChIP-Seq_VCAP_Human0.89789796

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.21573007
2MP0001929_abnormal_gametogenesis5.64423260
3MP0008877_abnormal_DNA_methylation4.24071620
4MP0002210_abnormal_sex_determination3.52032222
5MP0002161_abnormal_fertility/fecundity3.34608118
6MP0001145_abnormal_male_reproductive3.02669861
7MP0002653_abnormal_ependyma_morphology2.87446061
8MP0000653_abnormal_sex_gland2.64232967
9MP0005670_abnormal_white_adipose2.24586812
10MP0005623_abnormal_meninges_morphology2.01523032
11MP0005410_abnormal_fertilization16.2317759
12MP0009046_muscle_twitch1.50369772
13MP0002160_abnormal_reproductive_system1.49364999
14MP0004233_abnormal_muscle_weight1.46742706
15MP0002282_abnormal_trachea_morphology1.40327372
16MP0008058_abnormal_DNA_repair1.36213295
17MP0001765_abnormal_ion_homeostasis1.23073540
18MP0003646_muscle_fatigue1.20206334
19MP0001984_abnormal_olfaction1.02717927
20MP0005647_abnormal_sex_gland1.02697736
21MP0005389_reproductive_system_phenotype0.76902264
22MP0002234_abnormal_pharynx_morphology0.69568603
23MP0005636_abnormal_mineral_homeostasis0.67014563
24MP0002102_abnormal_ear_morphology0.65974758
25MP0008057_abnormal_DNA_replication0.62427417
26MP0010094_abnormal_chromosome_stability0.60955951
27MP0004036_abnormal_muscle_relaxation0.58872159
28MP0002928_abnormal_bile_duct0.57769917
29MP0003011_delayed_dark_adaptation0.56947553
30MP0001324_abnormal_eye_pigmentation0.54864088
31MP0003950_abnormal_plasma_membrane0.52525255
32MP0003699_abnormal_female_reproductive0.50758751
33MP0005551_abnormal_eye_electrophysiolog0.50691212
34MP0008995_early_reproductive_senescence0.48933055
35MP0004019_abnormal_vitamin_homeostasis0.48440654
36MP0003115_abnormal_respiratory_system0.47571543
37MP0000358_abnormal_cell_content/0.46426300
38MP0001293_anophthalmia0.46300633
39MP0003633_abnormal_nervous_system0.46169269
40MP0006036_abnormal_mitochondrial_physio0.44153085
41MP0005253_abnormal_eye_physiology0.42345965
42MP0002139_abnormal_hepatobiliary_system0.41393626
43MP0004133_heterotaxia0.41324759
44MP0002269_muscular_atrophy0.41095356
45MP0001764_abnormal_homeostasis0.39852957
46MP0002736_abnormal_nociception_after0.38301799
47MP0001119_abnormal_female_reproductive0.37441865
48MP0002132_abnormal_respiratory_system0.36940661
49MP0003329_amyloid_beta_deposits0.36331490
50MP0005377_hearing/vestibular/ear_phenot0.35528311
51MP0003878_abnormal_ear_physiology0.35528311
52MP0002971_abnormal_brown_adipose0.33983700
53MP0010307_abnormal_tumor_latency0.33851302
54MP0004084_abnormal_cardiac_muscle0.33503698
55MP0005666_abnormal_adipose_tissue0.33472503
56MP0009115_abnormal_fat_cell0.31542706
57MP0003631_nervous_system_phenotype0.31126839
58MP0008875_abnormal_xenobiotic_pharmacok0.30220428
59MP0005391_vision/eye_phenotype0.29372067
60MP0004811_abnormal_neuron_physiology0.28595125
61MP0000569_abnormal_digit_pigmentation0.27363334
62MP0004145_abnormal_muscle_electrophysio0.27123306
63MP0009697_abnormal_copulation0.26737761
64MP0006035_abnormal_mitochondrial_morpho0.26405419
65MP0005397_hematopoietic_system_phenotyp0.24511431
66MP0001545_abnormal_hematopoietic_system0.24511431
67MP0001968_abnormal_touch/_nociception0.24332643
68MP0005319_abnormal_enzyme/_coenzyme0.22843169
69MP0002152_abnormal_brain_morphology0.22830683
70MP0003861_abnormal_nervous_system0.22240472
71MP0002837_dystrophic_cardiac_calcinosis0.21141885
72MP0003786_premature_aging0.19922277
73MP0000313_abnormal_cell_death0.19534916
74MP0000604_amyloidosis0.19526584
75MP0002169_no_abnormal_phenotype0.19260320
76MP0002873_normal_phenotype0.19037658
77MP0005365_abnormal_bile_salt0.18553455
78MP0002229_neurodegeneration0.18085068
79MP0005195_abnormal_posterior_eye0.17886746
80MP0008007_abnormal_cellular_replicative0.17124448
81MP0001730_embryonic_growth_arrest0.16828092
82MP0002693_abnormal_pancreas_physiology0.16562966
83MP0005388_respiratory_system_phenotype0.16196645
84MP0002133_abnormal_respiratory_system0.16196645
85MP0008569_lethality_at_weaning0.15933255
86MP0006072_abnormal_retinal_apoptosis0.15544532
87MP0002572_abnormal_emotion/affect_behav0.14587317
88MP0002084_abnormal_developmental_patter0.14117518
89MP0009250_abnormal_appendicular_skeleto0.13954655
90MP0003111_abnormal_nucleus_morphology0.13936837
91MP0002405_respiratory_system_inflammati0.13835000
92MP0003948_abnormal_gas_homeostasis0.13786559
93MP0000534_abnormal_ureter_morphology0.13166203
94MP0004043_abnormal_pH_regulation0.12519316
95MP0004134_abnormal_chest_morphology0.12319557
96MP0000001_mammalian_phenotype0.11915913
97MP0002118_abnormal_lipid_homeostasis0.11608846
98MP0004270_analgesia0.11416141
99MP0004742_abnormal_vestibular_system0.11142039
100MP0009278_abnormal_bone_marrow0.10903268

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.59817988
2Abnormal respiratory motile cilium morphology (HP:0005938)9.10785746
3Abnormal respiratory epithelium morphology (HP:0012253)9.10785746
4Abnormal ciliary motility (HP:0012262)8.02811492
5Rhinitis (HP:0012384)7.66014799
6Chronic bronchitis (HP:0004469)7.52386075
7Nasal polyposis (HP:0100582)6.36966555
8Infertility (HP:0000789)6.12234735
9Abnormality of the nasal mucosa (HP:0000433)5.24001963
10Bronchitis (HP:0012387)4.60729396
11Bronchiectasis (HP:0002110)4.48149334
12Male infertility (HP:0003251)4.17939689
13Nephronophthisis (HP:0000090)4.11688907
14Recurrent sinusitis (HP:0011108)3.74412962
15Abnormal spermatogenesis (HP:0008669)3.40661969
16Recurrent otitis media (HP:0000403)3.29899693
17Abnormality of the renal medulla (HP:0100957)3.11021117
18Medial flaring of the eyebrow (HP:0010747)3.07229340
19Molar tooth sign on MRI (HP:0002419)2.86624029
20Abnormality of midbrain morphology (HP:0002418)2.86624029
21Tubulointerstitial nephritis (HP:0001970)2.84653375
22Recurrent bronchitis (HP:0002837)2.66291611
23Tubular atrophy (HP:0000092)2.58271837
24Azoospermia (HP:0000027)2.40117997
25Tubulointerstitial abnormality (HP:0001969)2.36009349
26Tongue fasciculations (HP:0001308)2.19368513
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.7551573
28Absent/shortened dynein arms (HP:0200106)13.1766133
29Dynein arm defect of respiratory motile cilia (HP:0012255)13.1766133
30Muscle fibrillation (HP:0010546)1.98364088
31Gait imbalance (HP:0002141)1.95105353
32Congenital primary aphakia (HP:0007707)1.94424310
33Postaxial foot polydactyly (HP:0001830)1.93925634
34Impulsivity (HP:0100710)1.89296114
35Chronic sinusitis (HP:0011109)1.85668504
36Pancreatic fibrosis (HP:0100732)1.85097233
37Congenital hepatic fibrosis (HP:0002612)1.84756210
38Tubulointerstitial fibrosis (HP:0005576)1.84527274
39Decreased central vision (HP:0007663)1.79040460
40Asymmetric septal hypertrophy (HP:0001670)1.76729642
41Gonadotropin excess (HP:0000837)1.76166991
42Stage 5 chronic kidney disease (HP:0003774)1.76142058
43Optic nerve hypoplasia (HP:0000609)1.75412035
44Abnormality of saccadic eye movements (HP:0000570)1.74369974
45Dyschromatopsia (HP:0007641)1.73260423
46Abnormal drinking behavior (HP:0030082)1.72414040
47Polydipsia (HP:0001959)1.72414040
48Microglossia (HP:0000171)1.71356033
49Cholecystitis (HP:0001082)1.71104832
50Abnormal gallbladder physiology (HP:0012438)1.71104832
51Abnormality of the renal cortex (HP:0011035)1.71031450
52Abnormality of renal excretion (HP:0011036)1.68956554
53Abnormality of the dental root (HP:0006486)1.66055966
54Taurodontia (HP:0000679)1.66055966
55Abnormality of permanent molar morphology (HP:0011071)1.66055966
56Nephrogenic diabetes insipidus (HP:0009806)1.65561162
57Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.63271909
58Postaxial hand polydactyly (HP:0001162)1.60557087
59Aplasia/Hypoplasia of the tongue (HP:0010295)1.59612463
60Aplasia/Hypoplasia of the lens (HP:0008063)1.56848642
61Abnormal biliary tract physiology (HP:0012439)1.56426129
62Bile duct proliferation (HP:0001408)1.56426129
63Fibular hypoplasia (HP:0003038)1.56384849
64Abnormality of molar morphology (HP:0011070)1.55914551
65Abnormality of molar (HP:0011077)1.55914551
66Oculomotor apraxia (HP:0000657)1.54532075
67Short ribs (HP:0000773)1.53736100
68Genital tract atresia (HP:0001827)1.53543984
69Abnormality of the dental pulp (HP:0006479)1.51926377
70Facial cleft (HP:0002006)1.51318530
71Cystic liver disease (HP:0006706)1.50051553
72Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.47630640
73Vaginal atresia (HP:0000148)1.47473860
74Absent frontal sinuses (HP:0002688)1.46647508
75Abnormality of ocular smooth pursuit (HP:0000617)1.46611544
76Impaired smooth pursuit (HP:0007772)1.44956977
77Heterotopia (HP:0002282)1.44423074
78Renal dysplasia (HP:0000110)1.44150022
79Poor coordination (HP:0002370)1.43721586
80Chronic hepatic failure (HP:0100626)1.43130660
81True hermaphroditism (HP:0010459)1.40658976
82Bundle branch block (HP:0011710)1.40593389
83Spastic tetraparesis (HP:0001285)1.38162370
84Vascular calcification (HP:0004934)1.37850379
85Abnormality of the lower motor neuron (HP:0002366)1.37307559
86Constricted visual fields (HP:0001133)1.34825943
87Hypoplasia of the capital femoral epiphysis (HP:0003090)1.33733256
88J-shaped sella turcica (HP:0002680)1.33696208
89Median cleft lip (HP:0000161)1.33638726
90Bell-shaped thorax (HP:0001591)1.28700239
91Choroideremia (HP:0001139)1.28089881
92Abnormality of dentin (HP:0010299)1.25653559
93Abnormal urine output (HP:0012590)1.24638789
94Cardiovascular calcification (HP:0011915)1.24036242
95Pancreatic cysts (HP:0001737)1.23273867
96Double outlet right ventricle (HP:0001719)1.22781435
97Congenital malformation of the right heart (HP:0011723)1.22781435
98Deformed sella turcica (HP:0002681)1.18605176
99Supernumerary spleens (HP:0009799)1.18400961
100Cerebellar dysplasia (HP:0007033)1.18248532

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.62707960
2PDK39.62707960
3PDK26.27275204
4TESK14.33812689
5PRKD33.25671079
6ICK2.91364189
7PTK2B2.12534312
8WNK41.95283108
9STK391.93693977
10PNCK1.41038807
11STK381.39628062
12NEK21.18666834
13PDK11.17090102
14LMTK21.07367450
15DYRK1B0.97997085
16IRAK10.89478181
17TYRO30.70615072
18DYRK30.66724440
19WNK10.63661773
20MAP2K60.59300301
21STK38L0.58963056
22CCNB10.58831225
23CHEK20.57649290
24PDPK10.57612961
25PASK0.57514794
26PLK40.52137008
27BRSK20.50234173
28STK30.49975496
29WEE10.48514938
30RIPK40.48377322
31MAPK150.47756080
32TTK0.46709295
33IRAK20.46379093
34CHEK10.37269803
35EEF2K0.36511589
36MAP2K70.34664991
37PINK10.30628464
38MUSK0.30349420
39TESK20.28458351
40PAK10.27640282
41PRKCG0.27371300
42CAMK1G0.27286046
43ATM0.24210044
44NEK60.23485202
45NTRK20.22605101
46ATR0.21854653
47ZAP700.18554001
48PRKG20.18347614
49BRSK10.18321977
50MAP3K40.17655710
51MARK30.17093726
52MAPKAPK50.16610658
53CDC70.15900643
54PKN10.15485926
55PAK20.14740674
56RPS6KB10.14519778
57PLK10.14173288
58PRKCZ0.13425633
59MAP3K100.13397013
60CAMKK10.13385829
61PRKAA10.12958543
62PRKCQ0.12670073
63MTOR0.12369048
64CDK120.10905432
65MARK20.10736349
66CDK150.09648043
67RIPK10.09393271
68YES10.09341852
69PRKG10.08628516
70PDGFRB0.08309613
71CSNK2A20.07450205
72CDK180.07351812
73CSNK2A10.07104976
74PRKACG0.06707789
75CDK11A0.06011370
76CAMK2A0.05495861
77STK100.05318015
78GSK3B0.04935942
79CDK140.04150861
80MAP3K50.04007117
81WNK30.03070635
82MAPK80.02896425
83CDK20.02752421
84GSK3A0.02681423
85CDK10.02546545
86STK110.02286453
87RPS6KA10.02241507
88PRKCD0.01911738
89CSNK1D0.01769677
90CSF1R0.01491135
91PRKCB0.01325114
92EGFR0.01272641
93PRKCA0.00884671
94OXSR10.00620457
95MAPK100.00303314
96BRAF0.00021213
97PRKACA-0.0090488
98PRKDC-0.0053214
99PRKACB-0.0048176
100MINK1-0.0045329

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.40301169
2Vitamin B6 metabolism_Homo sapiens_hsa007504.08677872
3Pyruvate metabolism_Homo sapiens_hsa006203.79572608
4Fatty acid biosynthesis_Homo sapiens_hsa000613.56995474
5Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.16468292
6Propanoate metabolism_Homo sapiens_hsa006402.99156881
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.62268689
8Glucagon signaling pathway_Homo sapiens_hsa049222.61713298
9Pentose phosphate pathway_Homo sapiens_hsa000302.57374770
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.56717207
11Basal transcription factors_Homo sapiens_hsa030222.53496742
12Linoleic acid metabolism_Homo sapiens_hsa005912.53221337
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.47678984
14Carbohydrate digestion and absorption_Homo sapiens_hsa049731.95037840
15Oocyte meiosis_Homo sapiens_hsa041141.93484477
16Glycerolipid metabolism_Homo sapiens_hsa005611.90060026
17Selenocompound metabolism_Homo sapiens_hsa004501.85947630
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.72639201
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.65628074
20PPAR signaling pathway_Homo sapiens_hsa033201.65022843
21Carbon metabolism_Homo sapiens_hsa012001.63176489
22Mineral absorption_Homo sapiens_hsa049781.49598862
23Glycerophospholipid metabolism_Homo sapiens_hsa005641.47971780
24Fanconi anemia pathway_Homo sapiens_hsa034601.46909290
25Amphetamine addiction_Homo sapiens_hsa050311.40732120
26Cardiac muscle contraction_Homo sapiens_hsa042601.37439531
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.33353823
28Huntingtons disease_Homo sapiens_hsa050161.32571454
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32432352
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.24127519
31Fat digestion and absorption_Homo sapiens_hsa049751.23090502
32Renin-angiotensin system_Homo sapiens_hsa046141.22645394
33Fructose and mannose metabolism_Homo sapiens_hsa000511.22485681
34Ether lipid metabolism_Homo sapiens_hsa005651.20326488
35Biosynthesis of amino acids_Homo sapiens_hsa012301.18526923
36Dorso-ventral axis formation_Homo sapiens_hsa043201.17267088
37Renin secretion_Homo sapiens_hsa049241.13397604
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.10168952
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07810529
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03938773
41Purine metabolism_Homo sapiens_hsa002301.03092394
42Fatty acid degradation_Homo sapiens_hsa000711.02595344
43Glutathione metabolism_Homo sapiens_hsa004800.99798338
44Fatty acid metabolism_Homo sapiens_hsa012120.98727040
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94390169
46Collecting duct acid secretion_Homo sapiens_hsa049660.94030265
47Antigen processing and presentation_Homo sapiens_hsa046120.89940365
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89226176
49mRNA surveillance pathway_Homo sapiens_hsa030150.88332719
50Chemical carcinogenesis_Homo sapiens_hsa052040.80291481
51Insulin secretion_Homo sapiens_hsa049110.79638705
52Systemic lupus erythematosus_Homo sapiens_hsa053220.78977465
53Bile secretion_Homo sapiens_hsa049760.78398667
54Inositol phosphate metabolism_Homo sapiens_hsa005620.74985772
55RNA transport_Homo sapiens_hsa030130.74308193
56Thyroid hormone synthesis_Homo sapiens_hsa049180.72114960
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69389739
58Long-term potentiation_Homo sapiens_hsa047200.67320437
59Sulfur metabolism_Homo sapiens_hsa009200.66584219
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66291982
61Calcium signaling pathway_Homo sapiens_hsa040200.64529999
62Estrogen signaling pathway_Homo sapiens_hsa049150.61869454
63Synaptic vesicle cycle_Homo sapiens_hsa047210.57745761
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.57170784
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57151551
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56568069
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.54468668
68Pancreatic secretion_Homo sapiens_hsa049720.53720995
69Arachidonic acid metabolism_Homo sapiens_hsa005900.52845572
70Taste transduction_Homo sapiens_hsa047420.52466918
71Protein digestion and absorption_Homo sapiens_hsa049740.50458740
72Salivary secretion_Homo sapiens_hsa049700.48986485
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47206335
74ABC transporters_Homo sapiens_hsa020100.47199994
75Metabolic pathways_Homo sapiens_hsa011000.45053109
76Gastric acid secretion_Homo sapiens_hsa049710.44689625
77Hedgehog signaling pathway_Homo sapiens_hsa043400.43781772
78Endocytosis_Homo sapiens_hsa041440.41278713
79Legionellosis_Homo sapiens_hsa051340.40500135
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39528750
81AMPK signaling pathway_Homo sapiens_hsa041520.38637725
82Circadian entrainment_Homo sapiens_hsa047130.37058982
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35460387
84cAMP signaling pathway_Homo sapiens_hsa040240.31207070
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.26831549
86Alcoholism_Homo sapiens_hsa050340.25635169
87N-Glycan biosynthesis_Homo sapiens_hsa005100.22838509
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18354751
89Cocaine addiction_Homo sapiens_hsa050300.17602752
90VEGF signaling pathway_Homo sapiens_hsa043700.16600352
91Lysine degradation_Homo sapiens_hsa003100.14577941
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14010244
93Salmonella infection_Homo sapiens_hsa051320.13933870
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.10416983
95Olfactory transduction_Homo sapiens_hsa047400.10181272
96Viral carcinogenesis_Homo sapiens_hsa052030.09267337
97Pyrimidine metabolism_Homo sapiens_hsa002400.08197211
98Retinol metabolism_Homo sapiens_hsa008300.08024833
99Dopaminergic synapse_Homo sapiens_hsa047280.07491263
100Glutamatergic synapse_Homo sapiens_hsa047240.07171361

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