LYZL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL4 is a member of a family of lysozyme-like genes (Zhang et al., 2005 [PubMed 16014814]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.43492139
2epithelial cilium movement (GO:0003351)9.13583852
3spermatid development (GO:0007286)9.03339910
4single fertilization (GO:0007338)7.82728783
5cilium movement (GO:0003341)7.36330352
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.20880546
7regulation of cilium movement (GO:0003352)6.99922244
8sperm capacitation (GO:0048240)6.67112944
9male meiosis (GO:0007140)6.60632526
10piRNA metabolic process (GO:0034587)6.59371618
11fertilization (GO:0009566)6.28791392
12synaptonemal complex organization (GO:0070193)6.18659948
13organic cation transport (GO:0015695)6.17435446
14microtubule depolymerization (GO:0007019)6.09558277
15spermatogenesis (GO:0007283)6.03672152
16synaptonemal complex assembly (GO:0007130)6.02107915
17male gamete generation (GO:0048232)6.01154570
18negative regulation of inclusion body assembly (GO:0090084)5.81433132
19calcium ion-dependent exocytosis (GO:0017156)5.79821683
20gamete generation (GO:0007276)5.52485836
21spermatid nucleus differentiation (GO:0007289)5.51097850
22cell recognition (GO:0008037)5.39270601
23cellular process involved in reproduction in multicellular organism (GO:0022412)5.20114622
24germ cell development (GO:0007281)4.97921704
25regulation of inclusion body assembly (GO:0090083)4.97240366
26ventricular system development (GO:0021591)4.67119639
27glycerol ether metabolic process (GO:0006662)4.44664082
28multicellular organismal reproductive process (GO:0048609)4.32553159
29DNA methylation involved in gamete generation (GO:0043046)4.28901500
30male meiosis I (GO:0007141)4.21449849
31regulation of microtubule-based movement (GO:0060632)4.15406246
32ether metabolic process (GO:0018904)4.09161425
33chromosome condensation (GO:0030261)4.05879265
34chromosome organization involved in meiosis (GO:0070192)4.05837279
35meiotic nuclear division (GO:0007126)3.91294909
36chaperone-mediated protein complex assembly (GO:0051131)3.90568533
37DNA packaging (GO:0006323)3.80148119
38seminiferous tubule development (GO:0072520)3.78691133
39microtubule severing (GO:0051013)3.76735210
40left/right pattern formation (GO:0060972)3.56961458
41sexual reproduction (GO:0019953)3.56501375
42protein localization to cilium (GO:0061512)3.55762764
43centriole assembly (GO:0098534)3.53106253
44sequestering of actin monomers (GO:0042989)3.50978867
45multicellular organismal development (GO:0007275)3.47698134
46meiosis I (GO:0007127)3.31129148
47protein K11-linked deubiquitination (GO:0035871)3.28530589
48microtubule polymerization or depolymerization (GO:0031109)3.15477857
49polyol catabolic process (GO:0046174)3.14524598
50single strand break repair (GO:0000012)3.14271407
51centriole replication (GO:0007099)3.13154958
52carnitine transport (GO:0015879)3.10039266
53amino-acid betaine transport (GO:0015838)3.10039266
54monoubiquitinated protein deubiquitination (GO:0035520)3.07353502
55positive regulation of macrophage activation (GO:0043032)3.04293372
56alditol metabolic process (GO:0019400)3.02558621
57carnitine transmembrane transport (GO:1902603)2.91652369
58meiotic cell cycle (GO:0051321)2.90337505
59macroautophagy (GO:0016236)2.90123087
60single-organism membrane fusion (GO:0044801)2.86517819
61regulation of spindle checkpoint (GO:0090231)2.86516447
62peptidyl-threonine dephosphorylation (GO:0035970)2.85566935
63cilium morphogenesis (GO:0060271)2.83123185
64interferon-gamma secretion (GO:0072643)2.80390056
65glycolytic process (GO:0006096)2.79176688
66axoneme assembly (GO:0035082)2.78162164
67glycerol metabolic process (GO:0006071)2.76735822
68cellular component assembly involved in morphogenesis (GO:0010927)2.66178667
69protein refolding (GO:0042026)2.65916333
70regulation of podosome assembly (GO:0071801)2.65669676
71cilium organization (GO:0044782)2.63913573
72microtubule-based movement (GO:0007018)2.63774983
73genitalia morphogenesis (GO:0035112)2.62669653
74ATP hydrolysis coupled proton transport (GO:0015991)2.59945649
75energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.59945649
76nucleoside diphosphate phosphorylation (GO:0006165)2.58914269
77cilium assembly (GO:0042384)2.57007065
78nucleus organization (GO:0006997)2.55932733
79regulation of cilium assembly (GO:1902017)2.55824261
80lactate metabolic process (GO:0006089)2.55499662
81response to acidic pH (GO:0010447)2.46770232
82intraciliary transport (GO:0042073)2.44714102
83protein polyglutamylation (GO:0018095)2.40683060
84cell redox homeostasis (GO:0045454)2.32160748
85regulation of centriole replication (GO:0046599)2.26636942
86quaternary ammonium group transport (GO:0015697)2.25609022
87fusion of sperm to egg plasma membrane (GO:0007342)16.5300813
88* cell wall macromolecule metabolic process (GO:0044036)14.8472869
89* cell wall macromolecule catabolic process (GO:0016998)14.8472869
90multicellular organism reproduction (GO:0032504)12.7452579
91plasma membrane fusion (GO:0045026)12.6224303
92acrosome assembly (GO:0001675)12.5987695
93sperm-egg recognition (GO:0035036)12.1498027
94sperm motility (GO:0030317)11.8685234
95acrosome reaction (GO:0007340)11.2841206
96cilium or flagellum-dependent cell motility (GO:0001539)11.0019438
97cell-cell recognition (GO:0009988)10.9347086
98reproduction (GO:0000003)10.7052037
99motile cilium assembly (GO:0044458)10.2463712
100binding of sperm to zona pellucida (GO:0007339)10.1627732

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.65354588
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.57743839
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.64675775
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.79609144
5EZH2_22144423_ChIP-Seq_EOC_Human2.43230009
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.31834078
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17520008
8ZNF274_21170338_ChIP-Seq_K562_Hela2.16140440
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.10418675
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00363345
11VDR_22108803_ChIP-Seq_LS180_Human1.97951853
12CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.92627154
13KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.91619295
14TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.90173362
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88901200
16ELK4_26923725_Chip-Seq_MESODERM_Mouse1.85862696
17* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.85210293
18CBX2_27304074_Chip-Seq_ESCs_Mouse1.82954488
19MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.81434198
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80302411
21KAP1_22055183_ChIP-Seq_ESCs_Mouse1.77064221
22STAT1_17558387_ChIP-Seq_HELA_Human1.69644790
23GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.68886156
24KDM2B_26808549_Chip-Seq_REH_Human1.68737437
25GATA3_21867929_ChIP-Seq_CD8_Mouse1.64921994
26WDR5_24793694_ChIP-Seq_LNCAP_Human1.61124590
27GATA1_26923725_Chip-Seq_HPCs_Mouse1.60249905
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59526695
29TAL1_26923725_Chip-Seq_HPCs_Mouse1.56500759
30PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50443316
31ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.47605082
32LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.47572984
33FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46848272
34FLI1_21867929_ChIP-Seq_TH2_Mouse1.46659916
35SOX2_22085726_ChIP-Seq_NPCs_Mouse1.44855427
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44356200
37RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.40489210
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38658451
39CBP_20019798_ChIP-Seq_JUKART_Human1.34240932
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34240932
41CRX_20693478_ChIP-Seq_RETINA_Mouse1.31666892
42GATA3_21867929_ChIP-Seq_TH1_Mouse1.28685450
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27733767
44TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27200384
45GF1_26923725_Chip-Seq_HPCs_Mouse1.26384295
46REST_21632747_ChIP-Seq_MESCs_Mouse1.24297623
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.24049995
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21430945
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20121725
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.18537345
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18119395
52PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17174713
53CMYC_18555785_Chip-Seq_ESCs_Mouse1.17043648
54P53_21459846_ChIP-Seq_SAOS-2_Human1.16949608
55EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16766702
56CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15105502
57FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14428286
58* IRF8_27001747_Chip-Seq_BMDM_Mouse1.13858936
59PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13813224
60SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12912453
61OCT4_18555785_Chip-Seq_ESCs_Mouse1.11816555
62P53_22387025_ChIP-Seq_ESCs_Mouse1.11182644
63NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11151365
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11011722
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10100232
66KLF4_18555785_Chip-Seq_ESCs_Mouse1.08477190
67EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06995621
68SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06705713
69KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.06488399
70P300_18555785_Chip-Seq_ESCs_Mouse1.06408829
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06361315
72SPI1_26923725_Chip-Seq_HPCs_Mouse1.04758331
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04085267
74RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03845447
75PU1_27457419_Chip-Seq_LIVER_Mouse1.02500697
76RARA_24833708_ChIP-Seq_LIVER_Mouse1.02272888
77TAF15_26573619_Chip-Seq_HEK293_Human1.02202417
78ESRRB_18555785_Chip-Seq_ESCs_Mouse1.01539611
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01363025
80SOX2_18555785_Chip-Seq_ESCs_Mouse1.01108012
81SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.00481997
82SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99887180
83OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99777774
84GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99579694
85EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99290977
86EZH2_27294783_Chip-Seq_NPCs_Mouse0.99224995
87LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98412757
88SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98325986
89CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97743882
90RUNX1_26923725_Chip-Seq_HPCs_Mouse0.97680110
91CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97578537
92ESET_19884257_ChIP-Seq_ESCs_Mouse0.97112290
93RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96339597
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95053618
95NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.94338445
96GF1B_26923725_Chip-Seq_HPCs_Mouse0.93895183
97CTCF_18555785_Chip-Seq_ESCs_Mouse0.92425348
98FLI1_21867929_ChIP-Seq_CD8_Mouse0.91971596
99RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91860679
100PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91714462

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.75375034
2MP0001929_abnormal_gametogenesis5.23584972
3MP0008877_abnormal_DNA_methylation4.04396480
4MP0002210_abnormal_sex_determination3.15000469
5MP0002161_abnormal_fertility/fecundity3.11709648
6MP0002653_abnormal_ependyma_morphology2.96107993
7MP0005670_abnormal_white_adipose2.75196483
8MP0001145_abnormal_male_reproductive2.70419320
9MP0004233_abnormal_muscle_weight2.46007231
10MP0000653_abnormal_sex_gland2.32200015
11MP0005410_abnormal_fertilization15.8497585
12MP0009046_muscle_twitch1.66433040
13MP0002160_abnormal_reproductive_system1.57811520
14MP0002234_abnormal_pharynx_morphology1.37784976
15MP0005623_abnormal_meninges_morphology1.33230496
16MP0001984_abnormal_olfaction1.21841716
17MP0006082_CNS_inflammation1.09965739
18MP0001765_abnormal_ion_homeostasis1.07224117
19MP0003646_muscle_fatigue1.02354901
20MP0003183_abnormal_peptide_metabolism0.92831664
21MP0002282_abnormal_trachea_morphology0.90822657
22MP0000604_amyloidosis0.82041776
23MP0002102_abnormal_ear_morphology0.78558901
24MP0002928_abnormal_bile_duct0.75256819
25MP0005389_reproductive_system_phenotype0.73528601
26MP0005647_abnormal_sex_gland0.69989135
27MP0003303_peritoneal_inflammation0.68142138
28MP0003011_delayed_dark_adaptation0.65835465
29MP0003436_decreased_susceptibility_to0.65360435
30MP0001324_abnormal_eye_pigmentation0.64656439
31MP0010307_abnormal_tumor_latency0.63628897
32MP0002419_abnormal_innate_immunity0.61244092
33MP0002269_muscular_atrophy0.61079862
34MP0003172_abnormal_lysosome_physiology0.57478883
35MP0005636_abnormal_mineral_homeostasis0.56726824
36MP0005174_abnormal_tail_pigmentation0.55276710
37MP0005058_abnormal_lysosome_morphology0.55141593
38MP0003633_abnormal_nervous_system0.54446616
39MP0002736_abnormal_nociception_after0.53719257
40MP0000015_abnormal_ear_pigmentation0.52179705
41MP0005257_abnormal_intraocular_pressure0.51210802
42MP0002405_respiratory_system_inflammati0.50440465
43MP0001835_abnormal_antigen_presentation0.50258926
44MP0000358_abnormal_cell_content/0.49118906
45MP0002148_abnormal_hypersensitivity_rea0.48062503
46MP0005551_abnormal_eye_electrophysiolog0.47099516
47MP0009115_abnormal_fat_cell0.45761624
48MP0005253_abnormal_eye_physiology0.45296003
49MP0001968_abnormal_touch/_nociception0.44721496
50MP0003705_abnormal_hypodermis_morpholog0.44688393
51MP0003690_abnormal_glial_cell0.44454033
52MP0005535_abnormal_body_temperature0.43808935
53MP0003136_yellow_coat_color0.42261801
54MP0003279_aneurysm0.42217701
55MP0005025_abnormal_response_to0.41905210
56MP0005166_decreased_susceptibility_to0.41588832
57MP0004019_abnormal_vitamin_homeostasis0.40998759
58MP0002971_abnormal_brown_adipose0.40531749
59MP0001851_eye_inflammation0.40042146
60MP0000343_altered_response_to0.39579849
61MP0003890_abnormal_embryonic-extraembry0.39490344
62MP0008469_abnormal_protein_level0.39279734
63MP0004130_abnormal_muscle_cell0.38499436
64MP0002723_abnormal_immune_serum0.37903082
65MP0002452_abnormal_antigen_presenting0.37164748
66MP0003448_altered_tumor_morphology0.36799748
67MP0008875_abnormal_xenobiotic_pharmacok0.36284444
68MP0008058_abnormal_DNA_repair0.35376160
69MP0003115_abnormal_respiratory_system0.34744815
70MP0004811_abnormal_neuron_physiology0.34257769
71MP0004036_abnormal_muscle_relaxation0.33796123
72MP0005409_darkened_coat_color0.33625545
73MP0005319_abnormal_enzyme/_coenzyme0.33536261
74MP0005000_abnormal_immune_tolerance0.32969590
75MP0003699_abnormal_female_reproductive0.32937000
76MP0005397_hematopoietic_system_phenotyp0.32877501
77MP0001545_abnormal_hematopoietic_system0.32877501
78MP0009278_abnormal_bone_marrow0.32424378
79MP0003329_amyloid_beta_deposits0.31872858
80MP0009785_altered_susceptibility_to0.31867617
81MP0002009_preneoplasia0.31577366
82MP0005666_abnormal_adipose_tissue0.30624086
83MP0002064_seizures0.30217524
84MP0006036_abnormal_mitochondrial_physio0.30129434
85MP0003631_nervous_system_phenotype0.29715114
86MP0003879_abnormal_hair_cell0.29327002
87MP0001845_abnormal_inflammatory_respons0.29288845
88MP0002557_abnormal_social/conspecific_i0.27224214
89MP0002139_abnormal_hepatobiliary_system0.27029321
90MP0008569_lethality_at_weaning0.26917777
91MP0005310_abnormal_salivary_gland0.26697522
92MP0002118_abnormal_lipid_homeostasis0.26263039
93MP0006035_abnormal_mitochondrial_morpho0.25874148
94MP0002693_abnormal_pancreas_physiology0.25550029
95MP0003300_gastrointestinal_ulcer0.25545899
96MP0001819_abnormal_immune_cell0.23142539
97MP0001764_abnormal_homeostasis0.23070709
98MP0010329_abnormal_lipoprotein_level0.22693667
99MP0005391_vision/eye_phenotype0.21893214
100MP0000609_abnormal_liver_physiology0.21869366

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.07994287
2Abnormal respiratory motile cilium morphology (HP:0005938)9.07994287
3Abnormal respiratory motile cilium physiology (HP:0012261)9.00490757
4Rhinitis (HP:0012384)7.74765730
5Chronic bronchitis (HP:0004469)7.26302188
6Abnormal ciliary motility (HP:0012262)7.13864926
7Nasal polyposis (HP:0100582)6.49796523
8Infertility (HP:0000789)6.01837920
9Abnormality of the nasal mucosa (HP:0000433)5.34496114
10Bronchiectasis (HP:0002110)4.39643824
11Bronchitis (HP:0012387)4.29022009
12Medial flaring of the eyebrow (HP:0010747)3.88511761
13Nephronophthisis (HP:0000090)3.34559878
14Congenital primary aphakia (HP:0007707)3.33491603
15Male infertility (HP:0003251)3.25703496
16Recurrent sinusitis (HP:0011108)3.21833615
17Gait imbalance (HP:0002141)3.21665473
18Abnormal spermatogenesis (HP:0008669)3.09903328
19Recurrent otitis media (HP:0000403)2.94789742
20Nephrogenic diabetes insipidus (HP:0009806)2.82263367
21Azoospermia (HP:0000027)2.60344776
22Abnormality of the renal medulla (HP:0100957)2.50008309
23Chronic sinusitis (HP:0011109)2.40835689
24Poor coordination (HP:0002370)2.39987648
25Tongue fasciculations (HP:0001308)2.36424254
26Aplasia/Hypoplasia of the lens (HP:0008063)2.34028095
27Recurrent bronchitis (HP:0002837)2.30835224
28Tubular atrophy (HP:0000092)2.25359575
29Vaginal atresia (HP:0000148)2.25311649
30Impulsivity (HP:0100710)2.24724346
31Muscle fibrillation (HP:0010546)2.22427431
32Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15726238
33Tubulointerstitial nephritis (HP:0001970)2.15578318
34Genital tract atresia (HP:0001827)2.15403131
35Molar tooth sign on MRI (HP:0002419)2.14138005
36Abnormality of midbrain morphology (HP:0002418)2.14138005
37Cholecystitis (HP:0001082)2.02624515
38Abnormal gallbladder physiology (HP:0012438)2.02624515
39Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.7844308
40Dynein arm defect of respiratory motile cilia (HP:0012255)12.6973400
41Absent/shortened dynein arms (HP:0200106)12.6973400
42Abnormality of saccadic eye movements (HP:0000570)1.99759616
43Loss of speech (HP:0002371)1.84293263
44Tubulointerstitial abnormality (HP:0001969)1.83441306
45Fatigable weakness (HP:0003473)1.76386799
46Abnormality of the neuromuscular junction (HP:0003398)1.76386799
47Impaired smooth pursuit (HP:0007772)1.74130264
48Spastic tetraparesis (HP:0001285)1.73681746
49Zonular cataract (HP:0010920)1.71618317
50Chronic otitis media (HP:0000389)1.71140968
51Sensory axonal neuropathy (HP:0003390)1.70239697
52Gonadotropin excess (HP:0000837)1.70028405
53Abnormality of ocular smooth pursuit (HP:0000617)1.69986517
54Easy fatigability (HP:0003388)1.69254994
55Asymmetric septal hypertrophy (HP:0001670)1.69250724
56Retinal atrophy (HP:0001105)1.66000303
57Type 2 muscle fiber atrophy (HP:0003554)1.61845063
58Heterotopia (HP:0002282)1.60673014
59Hypoplasia of the capital femoral epiphysis (HP:0003090)1.58504083
60Postaxial hand polydactyly (HP:0001162)1.54733151
61J-shaped sella turcica (HP:0002680)1.54194448
62Congenital hepatic fibrosis (HP:0002612)1.54085837
63Cerebellar dysplasia (HP:0007033)1.53235320
64Stage 5 chronic kidney disease (HP:0003774)1.51860989
65Tubulointerstitial fibrosis (HP:0005576)1.50275542
66Broad foot (HP:0001769)1.47117290
67Papillary thyroid carcinoma (HP:0002895)1.46455863
68Disinhibition (HP:0000734)1.45714646
69Slow saccadic eye movements (HP:0000514)1.44345908
70Dyschromatopsia (HP:0007641)1.42830907
71Neurofibrillary tangles (HP:0002185)1.41629920
72Decreased central vision (HP:0007663)1.41063199
73Abnormality of renal excretion (HP:0011036)1.40266542
74Polygenic inheritance (HP:0010982)1.38191237
75Oculomotor apraxia (HP:0000657)1.37538488
76Limb ataxia (HP:0002070)1.37192831
77Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.35857227
78Toxemia of pregnancy (HP:0100603)1.35611982
79Deformed sella turcica (HP:0002681)1.34223530
80Renal dysplasia (HP:0000110)1.33041538
81Decreased muscle mass (HP:0003199)1.32552709
82Neuronal loss in central nervous system (HP:0002529)1.32294687
83Muscle fiber atrophy (HP:0100295)1.31660429
84Abnormal drinking behavior (HP:0030082)1.31211679
85Polydipsia (HP:0001959)1.31211679
86Renovascular hypertension (HP:0100817)1.29792812
87Optic nerve hypoplasia (HP:0000609)1.29086406
88Vascular calcification (HP:0004934)1.26609302
89Upper motor neuron abnormality (HP:0002127)1.26497200
90Bulbar palsy (HP:0001283)1.25927984
91Specific learning disability (HP:0001328)1.25724595
92Constricted visual fields (HP:0001133)1.25643142
93Supernumerary spleens (HP:0009799)1.25607023
94Postaxial foot polydactyly (HP:0001830)1.23812579
95Polycystic ovaries (HP:0000147)1.23742548
96Cerebral inclusion bodies (HP:0100314)1.22422091
97Nonprogressive disorder (HP:0003680)1.22196472
98Choroideremia (HP:0001139)1.21802769
99Hemiparesis (HP:0001269)1.20255966
100Hypercholesterolemia (HP:0003124)1.19508045

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.37510333
2PDK48.37510333
3TESK16.03280311
4PDK25.45518569
5PRKD33.85723710
6ICK3.78243212
7PTK2B2.27475725
8WNK42.12792787
9STK392.08759343
10STK381.70878187
11IRAK11.44066780
12PNCK1.37261718
13NEK21.36912122
14RIPK41.35313683
15CDK121.30162165
16PDK11.27272734
17DYRK1B1.25632256
18PLK41.12060229
19TESK21.02939243
20LMTK20.87952503
21PDPK10.77384170
22WNK10.76322037
23CCNB10.75590429
24MAPK150.73554000
25CHEK20.70318218
26TYRO30.68832200
27STK30.68235546
28ERN10.65065858
29RIPK10.60770878
30BRSK20.55982871
31IRAK20.51726301
32GRK70.50284559
33MARK30.49215092
34MAP2K60.48075597
35CLK10.46832072
36PBK0.44746982
37PRKCG0.43630553
38YES10.42369893
39CSF1R0.42243884
40CAMK1G0.42205984
41TBK10.41242049
42CASK0.39052468
43CAMKK10.37402332
44PKN10.34566654
45PAK10.30495493
46EGFR0.30265686
47PAK40.28564825
48ZAP700.27685323
49EPHB10.27347125
50WEE10.25253750
51DYRK30.23204286
52MST1R0.23182429
53PASK0.22691100
54PINK10.22227972
55BRSK10.21846842
56CDK60.21496359
57AKT30.20857576
58TTK0.20624023
59PLK20.20428923
60KIT0.19117040
61STK38L0.18678413
62CHEK10.18618266
63MAP3K10.16598946
64PRKG10.16369466
65PAK20.16209639
66TGFBR20.15852267
67PRKCD0.13403217
68CDK150.12056125
69PRKG20.11822979
70PDGFRB0.11692921
71TYK20.10897671
72HCK0.10690828
73PRKCQ0.10619384
74ATM0.09864425
75CDK180.08896544
76PRKACG0.08803849
77CDK140.08711788
78MAP3K40.08001310
79ADRBK20.07565098
80SYK0.07099504
81EEF2K0.07009067
82MTOR0.06806912
83RPS6KA10.06751169
84CSK0.06707377
85PRKAA10.06150095
86PTK60.06083344
87BMX0.05737918
88MAPKAPK50.05706665
89BRAF0.05630123
90CAMK2A0.05534020
91CDK11A0.05347166
92TTN0.05051056
93STK100.05030217
94PRKCA0.04095328
95MAP2K70.03653804
96MAP3K20.03206290
97NEK60.03049800
98MAP3K50.03024970
99CSNK2A10.02710926
100LCK0.02646986

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.93650354
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.86590581
3Fatty acid biosynthesis_Homo sapiens_hsa000613.49656450
4Pyruvate metabolism_Homo sapiens_hsa006203.12991781
5Vitamin B6 metabolism_Homo sapiens_hsa007503.01286342
6Collecting duct acid secretion_Homo sapiens_hsa049662.62171052
7Propanoate metabolism_Homo sapiens_hsa006402.41934335
8Selenocompound metabolism_Homo sapiens_hsa004502.31420767
9Pentose phosphate pathway_Homo sapiens_hsa000302.27500298
10Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.25585900
11Glucagon signaling pathway_Homo sapiens_hsa049222.17676356
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.17352668
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.12807246
14Basal transcription factors_Homo sapiens_hsa030222.08152294
15Linoleic acid metabolism_Homo sapiens_hsa005912.01501807
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.00691942
17Synaptic vesicle cycle_Homo sapiens_hsa047211.92045980
18Glycerolipid metabolism_Homo sapiens_hsa005611.90769741
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.84527385
20Mineral absorption_Homo sapiens_hsa049781.79349458
21PPAR signaling pathway_Homo sapiens_hsa033201.76863088
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.51501172
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43605449
24Amphetamine addiction_Homo sapiens_hsa050311.39990364
25Oocyte meiosis_Homo sapiens_hsa041141.39519024
26Fructose and mannose metabolism_Homo sapiens_hsa000511.36806879
27N-Glycan biosynthesis_Homo sapiens_hsa005101.32726038
28Carbon metabolism_Homo sapiens_hsa012001.31853065
29Renin-angiotensin system_Homo sapiens_hsa046141.30673474
30Antigen processing and presentation_Homo sapiens_hsa046121.22955198
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.22041041
32Dorso-ventral axis formation_Homo sapiens_hsa043201.19489039
33Ether lipid metabolism_Homo sapiens_hsa005651.17215373
34Renin secretion_Homo sapiens_hsa049241.15581339
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08792355
36Cardiac muscle contraction_Homo sapiens_hsa042601.06687166
37Fat digestion and absorption_Homo sapiens_hsa049751.06617381
38Rheumatoid arthritis_Homo sapiens_hsa053231.05704968
39Huntingtons disease_Homo sapiens_hsa050161.04494082
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03051896
41Phagosome_Homo sapiens_hsa041451.02838100
42Staphylococcus aureus infection_Homo sapiens_hsa051500.99714445
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93072607
44Vibrio cholerae infection_Homo sapiens_hsa051100.91898155
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.88050741
46Fatty acid metabolism_Homo sapiens_hsa012120.83348429
47Fatty acid degradation_Homo sapiens_hsa000710.82843603
48Insulin secretion_Homo sapiens_hsa049110.80788634
49Systemic lupus erythematosus_Homo sapiens_hsa053220.78439516
50Fanconi anemia pathway_Homo sapiens_hsa034600.77471714
51Legionellosis_Homo sapiens_hsa051340.77048672
52Glutathione metabolism_Homo sapiens_hsa004800.76476645
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74691045
54Biosynthesis of amino acids_Homo sapiens_hsa012300.74426984
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74349504
56Long-term potentiation_Homo sapiens_hsa047200.72802144
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69141896
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67578594
59Other glycan degradation_Homo sapiens_hsa005110.67301996
60Inositol phosphate metabolism_Homo sapiens_hsa005620.67165476
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65903553
62Estrogen signaling pathway_Homo sapiens_hsa049150.64314563
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63079591
64Endocytosis_Homo sapiens_hsa041440.62894738
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.62801685
66Lysosome_Homo sapiens_hsa041420.59675926
67Salmonella infection_Homo sapiens_hsa051320.58675552
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55850746
69Calcium signaling pathway_Homo sapiens_hsa040200.55736427
70Purine metabolism_Homo sapiens_hsa002300.55423660
71Bile secretion_Homo sapiens_hsa049760.54312972
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53661679
73Thyroid hormone synthesis_Homo sapiens_hsa049180.52915804
74B cell receptor signaling pathway_Homo sapiens_hsa046620.52077311
75Salivary secretion_Homo sapiens_hsa049700.48917197
76Chemical carcinogenesis_Homo sapiens_hsa052040.47248512
77Osteoclast differentiation_Homo sapiens_hsa043800.44373150
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43234336
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42422658
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42298815
81Protein digestion and absorption_Homo sapiens_hsa049740.42058445
82Pancreatic secretion_Homo sapiens_hsa049720.42031719
83Olfactory transduction_Homo sapiens_hsa047400.41890636
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41874958
85Complement and coagulation cascades_Homo sapiens_hsa046100.40669642
86Gastric acid secretion_Homo sapiens_hsa049710.40049637
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.39768821
88Circadian entrainment_Homo sapiens_hsa047130.37271236
89ABC transporters_Homo sapiens_hsa020100.35441516
90Metabolic pathways_Homo sapiens_hsa011000.32428716
91Toxoplasmosis_Homo sapiens_hsa051450.31667435
92VEGF signaling pathway_Homo sapiens_hsa043700.30740800
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30088747
94Tuberculosis_Homo sapiens_hsa051520.29137386
95HIF-1 signaling pathway_Homo sapiens_hsa040660.29131619
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28004882
97Taste transduction_Homo sapiens_hsa047420.27940292
98Type II diabetes mellitus_Homo sapiens_hsa049300.26546782
99cAMP signaling pathway_Homo sapiens_hsa040240.26146312
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.24720182

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