LZIC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)5.21943251
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.18451768
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.14611110
4DNA strand elongation involved in DNA replication (GO:0006271)4.08948525
5ribosomal small subunit assembly (GO:0000028)4.03643574
6organelle disassembly (GO:1903008)4.03349555
7protein localization to kinetochore (GO:0034501)4.01345366
8ribonucleoprotein complex disassembly (GO:0032988)4.01304520
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.97234356
10DNA replication initiation (GO:0006270)3.96530757
11telomere maintenance via semi-conservative replication (GO:0032201)3.92876390
12CENP-A containing nucleosome assembly (GO:0034080)3.91483480
13DNA strand elongation (GO:0022616)3.87591995
14mitotic metaphase plate congression (GO:0007080)3.87296214
15DNA unwinding involved in DNA replication (GO:0006268)3.84945481
16protein complex biogenesis (GO:0070271)3.78733010
17nucleoside salvage (GO:0043174)3.78496403
18chromatin remodeling at centromere (GO:0031055)3.75978461
19formation of translation preinitiation complex (GO:0001731)3.74274656
20single strand break repair (GO:0000012)3.73615176
21mitochondrial respiratory chain complex assembly (GO:0033108)3.72676480
22pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.72079515
23UMP metabolic process (GO:0046049)3.72079515
24pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.72079515
25UMP biosynthetic process (GO:0006222)3.72079515
26resolution of meiotic recombination intermediates (GO:0000712)3.71094386
27mitotic nuclear envelope disassembly (GO:0007077)3.69086624
28protein localization to chromosome, centromeric region (GO:0071459)3.66681656
29respiratory chain complex IV assembly (GO:0008535)3.63103012
30DNA replication-independent nucleosome organization (GO:0034724)3.61938284
31DNA replication-independent nucleosome assembly (GO:0006336)3.61938284
32mitochondrial respiratory chain complex I assembly (GO:0032981)3.59567344
33NADH dehydrogenase complex assembly (GO:0010257)3.59567344
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.59567344
35maturation of SSU-rRNA (GO:0030490)3.56657622
36telomere maintenance via recombination (GO:0000722)3.51224506
37nucleobase biosynthetic process (GO:0046112)3.49818111
38kinetochore organization (GO:0051383)3.48275631
39mitotic recombination (GO:0006312)3.46267903
40purine nucleobase biosynthetic process (GO:0009113)3.43617402
41membrane disassembly (GO:0030397)3.42362309
42nuclear envelope disassembly (GO:0051081)3.42362309
43cullin deneddylation (GO:0010388)3.42221486
44DNA replication checkpoint (GO:0000076)3.36071651
45ribosome biogenesis (GO:0042254)3.34492416
46ATP synthesis coupled proton transport (GO:0015986)3.30958224
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.30958224
48tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.30013528
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.30013528
50ribosome assembly (GO:0042255)3.29905591
51DNA replication-dependent nucleosome assembly (GO:0006335)3.28667561
52DNA replication-dependent nucleosome organization (GO:0034723)3.28667561
53aldehyde catabolic process (GO:0046185)3.27315420
54respiratory electron transport chain (GO:0022904)3.25615878
55IMP biosynthetic process (GO:0006188)3.24633075
56telomere maintenance via telomere lengthening (GO:0010833)3.24556762
57histone exchange (GO:0043486)3.24026971
58metaphase plate congression (GO:0051310)3.22819929
59DNA ligation (GO:0006266)3.22714683
60viral mRNA export from host cell nucleus (GO:0046784)3.19774424
61electron transport chain (GO:0022900)3.19762020
62kinetochore assembly (GO:0051382)3.19180507
63viral transcription (GO:0019083)3.19009605
64translational termination (GO:0006415)3.17321586
65pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.16018874
66nucleotide salvage (GO:0043173)3.15990780
67cytochrome complex assembly (GO:0017004)3.14723625
68ribonucleoprotein complex biogenesis (GO:0022613)3.14108417
69L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.13648372
70pyrimidine-containing compound salvage (GO:0008655)3.13243588
71pyrimidine nucleoside salvage (GO:0043097)3.13243588
72regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.09742970
73establishment of chromosome localization (GO:0051303)3.09341063
74translational initiation (GO:0006413)3.09231112
75transcription from mitochondrial promoter (GO:0006390)3.09165585
76regulation of spindle organization (GO:0090224)3.09044225
77folic acid-containing compound biosynthetic process (GO:0009396)3.07904731
78attachment of spindle microtubules to kinetochore (GO:0008608)3.07439970
79nucleotide-excision repair, DNA gap filling (GO:0006297)3.06307653
80mitotic sister chromatid segregation (GO:0000070)3.05506015
81protein deneddylation (GO:0000338)3.05250846
82spliceosomal snRNP assembly (GO:0000387)3.04007639
83anterograde synaptic vesicle transport (GO:0048490)3.02955138
84mitotic chromosome condensation (GO:0007076)3.02736667
85DNA deamination (GO:0045006)3.02504589
86translational elongation (GO:0006414)3.00380125
87CTP metabolic process (GO:0046036)3.00115801
88CTP biosynthetic process (GO:0006241)3.00115801
89nuclear pore organization (GO:0006999)2.99150746
90water-soluble vitamin biosynthetic process (GO:0042364)2.98813253
91pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.98576301
92regulation of cilium movement (GO:0003352)2.98020495
93ribosomal large subunit biogenesis (GO:0042273)2.97519445
94ribosomal small subunit biogenesis (GO:0042274)2.97023931
95mitochondrial DNA replication (GO:0006264)2.96180378
96negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.92249159
97sister chromatid segregation (GO:0000819)2.90752846
98nuclear pore complex assembly (GO:0051292)2.89998129
99peptidyl-histidine modification (GO:0018202)2.89524030
100IMP metabolic process (GO:0046040)2.89432136
101intraciliary transport (GO:0042073)2.88906706
102replication fork processing (GO:0031297)2.86724603
103nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.84138360
104pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.84070090
105regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.83923681
106negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.83691381
107anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.83479491
108protein K6-linked ubiquitination (GO:0085020)2.82066228
109regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.81115298
110regulation of mitotic spindle checkpoint (GO:1903504)2.81115298
111nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80994996
112proteasome assembly (GO:0043248)2.79706735
113negative regulation of RNA splicing (GO:0033119)2.79429095
114regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.79065181
115exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.78117630
116negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.76807221
117negative regulation of sister chromatid segregation (GO:0033046)2.76807221
118negative regulation of mitotic sister chromatid separation (GO:2000816)2.76807221
119negative regulation of mitotic sister chromatid segregation (GO:0033048)2.76807221
120rRNA processing (GO:0006364)2.75527850
121negative regulation of chromosome segregation (GO:0051985)2.74873600
122ATP-dependent chromatin remodeling (GO:0043044)2.74871407
123chromatin assembly or disassembly (GO:0006333)2.74829406
124spindle checkpoint (GO:0031577)2.73125225
125positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.72938922
126spindle assembly checkpoint (GO:0071173)2.72577527
127L-methionine salvage (GO:0071267)2.72495839
128L-methionine biosynthetic process (GO:0071265)2.72495839
129amino acid salvage (GO:0043102)2.72495839
130mitotic spindle assembly checkpoint (GO:0007094)2.72304160
131nuclear envelope organization (GO:0006998)2.71356826
132cell cycle G1/S phase transition (GO:0044843)2.70515705
133G1/S transition of mitotic cell cycle (GO:0000082)2.70515705
134DNA duplex unwinding (GO:0032508)2.70161354
135DNA double-strand break processing (GO:0000729)2.69861654
136negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.68697478
137DNA geometric change (GO:0032392)2.68406724
138protein K11-linked ubiquitination (GO:0070979)2.65904161
139double-strand break repair via nonhomologous end joining (GO:0006303)2.65431259
140non-recombinational repair (GO:0000726)2.65431259
141intracellular protein transmembrane import (GO:0044743)2.64745978
142keratinocyte development (GO:0003334)2.64709110
143T cell apoptotic process (GO:0070231)2.64629117
144rRNA metabolic process (GO:0016072)2.64550619
145SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.64132391
146regulation of chromosome segregation (GO:0051983)2.62834578
147protein localization to chromosome (GO:0034502)2.62685118
148regulation of mitotic metaphase/anaphase transition (GO:0030071)2.62395424
149protein targeting to mitochondrion (GO:0006626)2.62180315
150transcription-coupled nucleotide-excision repair (GO:0006283)2.62110914
151pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.61954949
152negative regulation of ligase activity (GO:0051352)2.61725135
153negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.61725135
154platelet dense granule organization (GO:0060155)2.61022181
155centriole replication (GO:0007099)2.60779045
156telomere maintenance (GO:0000723)2.60702311
157telomere organization (GO:0032200)2.60386197
158pseudouridine synthesis (GO:0001522)2.59920395
159deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.59655833
160regulation of protein heterodimerization activity (GO:0043497)2.59422367
161postreplication repair (GO:0006301)2.59260377
162mitotic spindle checkpoint (GO:0071174)2.58899254
163pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.58776753
164protein localization to mitochondrion (GO:0070585)2.58475868
165anterograde axon cargo transport (GO:0008089)2.58265937
166pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.57905834
167RNA splicing, via transesterification reactions (GO:0000375)2.57388492
168nucleobase-containing small molecule interconversion (GO:0015949)2.56816815
169regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.56456345
170DNA-dependent DNA replication (GO:0006261)2.54986745
171chaperone-mediated protein transport (GO:0072321)2.53771739
172protein-cofactor linkage (GO:0018065)2.51043918
173termination of RNA polymerase III transcription (GO:0006386)2.49173213
174transcription elongation from RNA polymerase III promoter (GO:0006385)2.49173213
175DNA catabolic process, exonucleolytic (GO:0000738)2.45896460
176regulation of meiosis I (GO:0060631)2.44592573
177pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.43682624
178pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.43445447
179establishment of integrated proviral latency (GO:0075713)2.42926697
180mismatch repair (GO:0006298)2.42631231
181establishment of protein localization to mitochondrion (GO:0072655)2.42296414
182piRNA metabolic process (GO:0034587)2.42074789
183lactate metabolic process (GO:0006089)2.40484286
184regulation of cellular amino acid metabolic process (GO:0006521)2.40045199
185protein heterotetramerization (GO:0051290)2.38337767
186neural tube formation (GO:0001841)2.38218588

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.71722158
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.17818146
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.97201871
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.87573220
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.39542720
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.09387050
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.95296827
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.93865182
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.83983852
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.73293252
11* GABP_17652178_ChIP-ChIP_JURKAT_Human2.72813016
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71668573
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.70421709
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62930557
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60680539
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.59586588
17* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.57787586
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.40516947
19GBX2_23144817_ChIP-Seq_PC3_Human2.38830617
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.35218033
21FUS_26573619_Chip-Seq_HEK293_Human2.31118820
22ZNF274_21170338_ChIP-Seq_K562_Hela2.29932878
23XRN2_22483619_ChIP-Seq_HELA_Human2.26918674
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.24757267
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19502028
26TAF15_26573619_Chip-Seq_HEK293_Human2.15269055
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15000072
28VDR_23849224_ChIP-Seq_CD4+_Human2.12643837
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10979427
30AR_21909140_ChIP-Seq_LNCAP_Human2.06473363
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04591583
32EWS_26573619_Chip-Seq_HEK293_Human2.03504939
33ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03443767
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99353816
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94355044
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.92858491
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91966287
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91302540
39FOXP3_21729870_ChIP-Seq_TREG_Human1.91001760
40DCP1A_22483619_ChIP-Seq_HELA_Human1.89935494
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.87461578
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85320991
43MYC_22102868_ChIP-Seq_BL_Human1.82728735
44* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82512246
45ELK1_19687146_ChIP-ChIP_HELA_Human1.81616028
46* GABP_19822575_ChIP-Seq_HepG2_Human1.80880857
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.79874535
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78276800
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77594901
50P300_19829295_ChIP-Seq_ESCs_Human1.73785796
51CIITA_25753668_ChIP-Seq_RAJI_Human1.72789525
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.72508795
53TTF2_22483619_ChIP-Seq_HELA_Human1.72087888
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70083970
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67882979
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67683449
57IGF1R_20145208_ChIP-Seq_DFB_Human1.67498018
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64369339
59* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61385994
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.61236271
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60060302
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57601616
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57168801
64VDR_22108803_ChIP-Seq_LS180_Human1.55781604
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55303918
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52171689
67* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50470759
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49872469
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.46897691
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46445650
71* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44111903
72* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43369453
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42874834
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.42248900
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41403012
76KDM5A_27292631_Chip-Seq_BREAST_Human1.40260743
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39017890
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.37841018
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36733927
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.36347324
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35442917
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33165105
83* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32874780
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31549973
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.31440666
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29853576
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29572070
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29047093
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28375444
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28121295
91HTT_18923047_ChIP-ChIP_STHdh_Human1.27698846
92TP63_19390658_ChIP-ChIP_HaCaT_Human1.27298137
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27294333
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26850409
95CBP_20019798_ChIP-Seq_JUKART_Human1.26850409
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25971859
97TP53_22573176_ChIP-Seq_HFKS_Human1.25713197
98SMAD4_21799915_ChIP-Seq_A2780_Human1.25283093
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25042731
100IRF1_19129219_ChIP-ChIP_H3396_Human1.24812700
101VDR_21846776_ChIP-Seq_THP-1_Human1.24117976
102* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21594883
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.20730107
104SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20669291
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20084053
106MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19769231
107TFEB_21752829_ChIP-Seq_HELA_Human1.19061379
108PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17557398
109SALL4_22934838_ChIP-ChIP_CD34+_Human1.14054558
110E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13923991
111STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13553722
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13199957
113ER_23166858_ChIP-Seq_MCF-7_Human1.12826892
114BCAT_22108803_ChIP-Seq_LS180_Human1.12340327
115DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12151995
116CRX_20693478_ChIP-Seq_RETINA_Mouse1.10103872
117P53_22387025_ChIP-Seq_ESCs_Mouse1.08906613
118HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08806122
119DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07735366
120MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07349134
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06596991
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06285281
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05306337
124SPI1_23547873_ChIP-Seq_NB4_Human1.04936650
125PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03967244
126E2F1_18555785_Chip-Seq_ESCs_Mouse1.02974242
127FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02853728
128POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02608366
129TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02607313
130PIAS1_25552417_ChIP-Seq_VCAP_Human1.02420979
131SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01825011
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01774468
133NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01687024
134CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01465815
135CMYC_18555785_Chip-Seq_ESCs_Mouse1.01387900
136SOX2_19829295_ChIP-Seq_ESCs_Human1.01143506
137NANOG_19829295_ChIP-Seq_ESCs_Human1.01143506
138SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00780446
139EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00702056
140TCF4_22108803_ChIP-Seq_LS180_Human1.00552158
141POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00291336
142CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99982610
143* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99829518
144SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99516322
145STAT3_18555785_Chip-Seq_ESCs_Mouse0.98680649
146BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98597003
147POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98486040
148* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98437764
149GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98284431
150TCF4_23295773_ChIP-Seq_U87_Human0.98178625
151ELK1_22589737_ChIP-Seq_MCF10A_Human0.96603115
152CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94935192
153CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94931546
154NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94781994
155CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93086355
156KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92495335
157CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92392001
158TP63_17297297_ChIP-ChIP_HaCaT_Human0.92013519
159HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89920743
160NANOG_21062744_ChIP-ChIP_HESCs_Human0.88419343
161CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88363866
162ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88316112
163KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88252336
164MYB_26560356_Chip-Seq_TH2_Human0.83532853
165SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82815896
166IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.82374789
167MAF_26560356_Chip-Seq_TH1_Human0.80022330
168MYC_18940864_ChIP-ChIP_HL60_Human0.79961289

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.17032318
2MP0010094_abnormal_chromosome_stability3.54579836
3MP0003077_abnormal_cell_cycle3.36983318
4MP0004957_abnormal_blastocyst_morpholog3.35173157
5MP0003111_abnormal_nucleus_morphology3.33963927
6MP0000569_abnormal_digit_pigmentation3.29002224
7MP0008007_abnormal_cellular_replicative2.85146799
8MP0002396_abnormal_hematopoietic_system2.78668963
9MP0008057_abnormal_DNA_replication2.60764449
10MP0008058_abnormal_DNA_repair2.53999336
11MP0000372_irregular_coat_pigmentation2.49810159
12MP0003122_maternal_imprinting2.31884258
13MP0005084_abnormal_gallbladder_morpholo2.29544116
14MP0003195_calcinosis2.18539477
15MP0002163_abnormal_gland_morphology2.14250518
16MP0008932_abnormal_embryonic_tissue2.12290511
17MP0009697_abnormal_copulation2.09710059
18MP0001984_abnormal_olfaction2.08787902
19MP0010352_gastrointestinal_tract_polyps2.02643117
20MP0001529_abnormal_vocalization2.02181714
21MP0000350_abnormal_cell_proliferation2.00049351
22MP0002837_dystrophic_cardiac_calcinosis1.99628841
23MP0001730_embryonic_growth_arrest1.98860892
24MP0006072_abnormal_retinal_apoptosis1.83646936
25MP0003787_abnormal_imprinting1.83593308
26MP0000490_abnormal_crypts_of1.77518301
27MP0006276_abnormal_autonomic_nervous1.76741151
28MP0006054_spinal_hemorrhage1.69533969
29MP0005408_hypopigmentation1.68840903
30MP0004808_abnormal_hematopoietic_stem1.68115354
31MP0001672_abnormal_embryogenesis/_devel1.64266967
32MP0005380_embryogenesis_phenotype1.64266967
33MP0003984_embryonic_growth_retardation1.61092445
34MP0008789_abnormal_olfactory_epithelium1.60515690
35MP0010307_abnormal_tumor_latency1.58823356
36MP0001697_abnormal_embryo_size1.56817062
37MP0002088_abnormal_embryonic_growth/wei1.56418871
38MP0005187_abnormal_penis_morphology1.55154244
39MP0006292_abnormal_olfactory_placode1.54225928
40MP0006035_abnormal_mitochondrial_morpho1.52862287
41MP0003567_abnormal_fetal_cardiomyocyte1.50816154
42MP0004142_abnormal_muscle_tone1.49666371
43MP0005253_abnormal_eye_physiology1.48623779
44MP0003763_abnormal_thymus_physiology1.48533580
45MP0002234_abnormal_pharynx_morphology1.48352469
46MP0004084_abnormal_cardiac_muscle1.47754708
47MP0002638_abnormal_pupillary_reflex1.43932208
48MP0002736_abnormal_nociception_after1.43495595
49MP0006036_abnormal_mitochondrial_physio1.43174759
50MP0003705_abnormal_hypodermis_morpholog1.42898599
51MP0005379_endocrine/exocrine_gland_phen1.41612641
52MP0000313_abnormal_cell_death1.40662451
53MP0002080_prenatal_lethality1.38982916
54MP0002090_abnormal_vision1.37710282
55MP0000631_abnormal_neuroendocrine_gland1.35641233
56MP0000516_abnormal_urinary_system1.35039670
57MP0005367_renal/urinary_system_phenotyp1.35039670
58MP0005076_abnormal_cell_differentiation1.33177446
59MP0002019_abnormal_tumor_incidence1.31937918
60MP0005394_taste/olfaction_phenotype1.30425174
61MP0005499_abnormal_olfactory_system1.30425174
62MP0000750_abnormal_muscle_regeneration1.30103349
63MP0009333_abnormal_splenocyte_physiolog1.29842288
64MP0002085_abnormal_embryonic_tissue1.29260891
65MP0008438_abnormal_cutaneous_collagen1.28214859
66MP0005551_abnormal_eye_electrophysiolog1.27234167
67MP0002822_catalepsy1.25765078
68MP0002086_abnormal_extraembryonic_tissu1.25232666
69MP0005397_hematopoietic_system_phenotyp1.25183464
70MP0001545_abnormal_hematopoietic_system1.25183464
71MP0004147_increased_porphyrin_level1.21972195
72MP0002398_abnormal_bone_marrow1.21913809
73MP0003221_abnormal_cardiomyocyte_apopto1.20820527
74MP0002735_abnormal_chemical_nociception1.20691057
75MP0003950_abnormal_plasma_membrane1.20654186
76MP0003136_yellow_coat_color1.20325530
77MP0003011_delayed_dark_adaptation1.19707187
78MP0004197_abnormal_fetal_growth/weight/1.19594968
79MP0005174_abnormal_tail_pigmentation1.17741169
80MP0002084_abnormal_developmental_patter1.17704587
81MP0003786_premature_aging1.14989202
82MP0002233_abnormal_nose_morphology1.14856636
83MP0002095_abnormal_skin_pigmentation1.14194602
84MP0000733_abnormal_muscle_development1.13868853
85MP0000703_abnormal_thymus_morphology1.13705165
86MP0000647_abnormal_sebaceous_gland1.13698420
87MP0008875_abnormal_xenobiotic_pharmacok1.12470904
88MP0003123_paternal_imprinting1.12459239
89MP0003252_abnormal_bile_duct1.11071849
90MP0003279_aneurysm1.10150373
91MP0001849_ear_inflammation1.09903091
92MP0005023_abnormal_wound_healing1.09498726
93MP0001348_abnormal_lacrimal_gland1.09477875
94MP0004885_abnormal_endolymph1.07216736
95MP0003880_abnormal_central_pattern1.06471494
96MP0003646_muscle_fatigue1.05790459
97MP0002722_abnormal_immune_system1.04550073
98MP0010030_abnormal_orbit_morphology1.03849268
99MP0009053_abnormal_anal_canal1.03479419
100MP0001485_abnormal_pinna_reflex1.02297410
101MP0001293_anophthalmia1.00976011
102MP0000858_altered_metastatic_potential1.00366557
103MP0010329_abnormal_lipoprotein_level0.99990087
104MP0003890_abnormal_embryonic-extraembry0.99714962
105MP0005365_abnormal_bile_salt0.99492587
106MP0001853_heart_inflammation0.98449580
107MP0000689_abnormal_spleen_morphology0.98139822
108MP0003566_abnormal_cell_adhesion0.97618222
109MP0000358_abnormal_cell_content/0.97364228
110MP0001324_abnormal_eye_pigmentation0.97028998
111MP0003718_maternal_effect0.97018707
112MP0001929_abnormal_gametogenesis0.96069907
113MP0002160_abnormal_reproductive_system0.96055957
114MP0005389_reproductive_system_phenotype0.95899640
115MP0000685_abnormal_immune_system0.95504492
116MP0008872_abnormal_physiological_respon0.94414458
117MP0009046_muscle_twitch0.92813706
118MP0003186_abnormal_redox_activity0.92463256
119MP0005646_abnormal_pituitary_gland0.92426033
120MP0002429_abnormal_blood_cell0.91831505
121MP0001915_intracranial_hemorrhage0.89436702
122MP0005391_vision/eye_phenotype0.89154551
123MP0002909_abnormal_adrenal_gland0.88266323
124MP0002751_abnormal_autonomic_nervous0.87589465
125MP0002184_abnormal_innervation0.87140313
126MP0005195_abnormal_posterior_eye0.86830593
127MP0010630_abnormal_cardiac_muscle0.86054232
128MP0005671_abnormal_response_to0.85851881
129MP0003868_abnormal_feces_composition0.84340209
130MP0005171_absent_coat_pigmentation0.84261647
131MP0008877_abnormal_DNA_methylation0.82945943
132MP0000716_abnormal_immune_system0.82887982
133MP0000778_abnormal_nervous_system0.82674340
134MP0000427_abnormal_hair_cycle0.82626246
135MP0005645_abnormal_hypothalamus_physiol0.81980444
136MP0005248_abnormal_Harderian_gland0.81290288
137MP0001919_abnormal_reproductive_system0.81050245
138MP0001286_abnormal_eye_development0.81025269
139MP0002938_white_spotting0.80966061
140MP0000653_abnormal_sex_gland0.80371090
141MP0004924_abnormal_behavior0.79911444
142MP0005386_behavior/neurological_phenoty0.79911444
143MP0002405_respiratory_system_inflammati0.78952838
144MP0002102_abnormal_ear_morphology0.78621324
145MP0005332_abnormal_amino_acid0.78429062
146MP0002139_abnormal_hepatobiliary_system0.77496126
147MP0003698_abnormal_male_reproductive0.77307687
148MP0005330_cardiomyopathy0.77199161
149MP0001764_abnormal_homeostasis0.75785657
150MP0001835_abnormal_antigen_presentation0.74556706
151MP0000428_abnormal_craniofacial_morphol0.74137828
152MP0001800_abnormal_humoral_immune0.73915573
153MP0005384_cellular_phenotype0.73378482
154MP0009384_cardiac_valve_regurgitation0.72132494
155MP0000465_gastrointestinal_hemorrhage0.70991789
156MP0001544_abnormal_cardiovascular_syste0.70951432
157MP0005385_cardiovascular_system_phenoty0.70951432
158MP0003448_altered_tumor_morphology0.70929313
159MP0004233_abnormal_muscle_weight0.70584626
160MP0002111_abnormal_tail_morphology0.70076403
161MP0005621_abnormal_cell_physiology0.69926325
162MP0002210_abnormal_sex_determination0.69456896
163MP0004215_abnormal_myocardial_fiber0.69415865
164MP0002925_abnormal_cardiovascular_devel0.69206649
165MP0000266_abnormal_heart_morphology0.68856096
166MP0002420_abnormal_adaptive_immunity0.68586557
167MP0002452_abnormal_antigen_presenting0.68546187
168MP0001819_abnormal_immune_cell0.67666793
169MP0003942_abnormal_urinary_system0.67656906
170MP0000477_abnormal_intestine_morphology0.67156587
171MP0003937_abnormal_limbs/digits/tail_de0.66510380
172MP0002166_altered_tumor_susceptibility0.66215416
173MP0005623_abnormal_meninges_morphology0.65949959
174MP0003806_abnormal_nucleotide_metabolis0.65914920
175MP0002269_muscular_atrophy0.65725883
176MP0003315_abnormal_perineum_morphology0.64097014
177MP0003121_genomic_imprinting0.63874159

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.44499549
2Acute encephalopathy (HP:0006846)4.17205249
3Progressive macrocephaly (HP:0004481)4.14227273
4Increased hepatocellular lipid droplets (HP:0006565)3.92620464
5Mitochondrial inheritance (HP:0001427)3.79787019
6Abnormal mitochondria in muscle tissue (HP:0008316)3.79778621
7Increased CSF lactate (HP:0002490)3.61517064
8Birth length less than 3rd percentile (HP:0003561)3.56316068
9Lipid accumulation in hepatocytes (HP:0006561)3.51361314
10Selective tooth agenesis (HP:0001592)3.47560637
11Degeneration of anterior horn cells (HP:0002398)3.41292573
12Abnormality of the anterior horn cell (HP:0006802)3.41292573
13Renal Fanconi syndrome (HP:0001994)3.23113448
14Pancreatic cysts (HP:0001737)3.18940258
15Reticulocytopenia (HP:0001896)3.16962013
16Aplastic anemia (HP:0001915)3.09799019
17Hepatic necrosis (HP:0002605)3.05665621
18Hepatocellular necrosis (HP:0001404)2.91446128
19Pancreatic fibrosis (HP:0100732)2.90966937
203-Methylglutaconic aciduria (HP:0003535)2.87105074
21Abnormality of the labia minora (HP:0012880)2.85133813
22Medial flaring of the eyebrow (HP:0010747)2.81589215
23Abnormality of cells of the erythroid lineage (HP:0012130)2.80964482
24Multiple enchondromatosis (HP:0005701)2.79466499
25Abnormal number of erythroid precursors (HP:0012131)2.76341459
26Cerebral edema (HP:0002181)2.76214201
27Oral leukoplakia (HP:0002745)2.75625977
28Patellar aplasia (HP:0006443)2.75328496
29Aplasia/Hypoplasia of the patella (HP:0006498)2.71105263
30Glycosuria (HP:0003076)2.69812353
31Abnormality of urine glucose concentration (HP:0011016)2.69812353
32Short 4th metacarpal (HP:0010044)2.67033810
33Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.67033810
34Abnormality of midbrain morphology (HP:0002418)2.62560237
35Molar tooth sign on MRI (HP:0002419)2.62560237
36Breast hypoplasia (HP:0003187)2.61369184
37True hermaphroditism (HP:0010459)2.54235102
38Protrusio acetabuli (HP:0003179)2.50941588
39Poor suck (HP:0002033)2.47762644
40Increased serum lactate (HP:0002151)2.46933815
41Thrombocytosis (HP:0001894)2.40877006
42Hypoglycemic coma (HP:0001325)2.40326152
43Papillary thyroid carcinoma (HP:0002895)2.40197687
44Colon cancer (HP:0003003)2.39107607
45Increased intramyocellular lipid droplets (HP:0012240)2.38896208
46Exertional dyspnea (HP:0002875)2.38757661
47Abnormality of renal resorption (HP:0011038)2.37905247
48Gait imbalance (HP:0002141)2.35229812
49Intestinal atresia (HP:0011100)2.34965504
50Congenital primary aphakia (HP:0007707)2.34893131
51Hyperglycinemia (HP:0002154)2.32318819
52Ankle contracture (HP:0006466)2.31735042
53Hip dysplasia (HP:0001385)2.31385625
54Lactic acidosis (HP:0003128)2.28037023
55Short tibia (HP:0005736)2.25908997
56Congenital, generalized hypertrichosis (HP:0004540)2.24796034
57Nephrogenic diabetes insipidus (HP:0009806)2.23089172
58Renal cortical cysts (HP:0000803)2.20630154
59Chromsome breakage (HP:0040012)2.19205252
6011 pairs of ribs (HP:0000878)2.18435920
61Respiratory failure (HP:0002878)2.17648898
62Proximal tubulopathy (HP:0000114)2.17172131
63Myelodysplasia (HP:0002863)2.16753190
64Cutaneous melanoma (HP:0012056)2.15524396
65Leukodystrophy (HP:0002415)2.14646461
66Hyperphosphaturia (HP:0003109)2.14339865
67Neoplasm of the pancreas (HP:0002894)2.13920631
68Nephronophthisis (HP:0000090)2.11628256
69Meckel diverticulum (HP:0002245)2.10386251
70Medulloblastoma (HP:0002885)2.10234216
71Abnormality of the renal cortex (HP:0011035)2.09819367
72Slender long bone (HP:0003100)2.09802723
73Microretrognathia (HP:0000308)2.09451155
74Abnormality of the pons (HP:0007361)2.08799684
75Neuroendocrine neoplasm (HP:0100634)2.08708264
76Abnormal number of incisors (HP:0011064)2.08686878
77CNS demyelination (HP:0007305)2.08531654
78Abnormality of chromosome stability (HP:0003220)2.07035484
79Trismus (HP:0000211)2.06382899
80Abnormality of the 4th metacarpal (HP:0010012)2.05455827
81Cerebral hypomyelination (HP:0006808)2.05051888
82Aplasia/Hypoplasia of the tibia (HP:0005772)2.04581620
83Squamous cell carcinoma (HP:0002860)2.04368863
84Pheochromocytoma (HP:0002666)2.03601015
85Generalized aminoaciduria (HP:0002909)2.03285856
86Atrophy/Degeneration involving motor neurons (HP:0007373)2.01158677
87Aplasia/Hypoplasia of the tongue (HP:0010295)2.00781305
88Thyroid carcinoma (HP:0002890)1.97901104
89Abnormality of the ileum (HP:0001549)1.97113150
90Hypothermia (HP:0002045)1.96506944
91Exercise intolerance (HP:0003546)1.96037524
92Rhabdomyosarcoma (HP:0002859)1.95959805
93Pallor (HP:0000980)1.95525154
94Rough bone trabeculation (HP:0100670)1.95064636
95IgM deficiency (HP:0002850)1.94034816
96Deviation of the thumb (HP:0009603)1.93275379
97Carpal bone hypoplasia (HP:0001498)1.93218211
98Genital tract atresia (HP:0001827)1.93087903
99Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.90261119
100Abnormality of the preputium (HP:0100587)1.89806551
101Basal cell carcinoma (HP:0002671)1.89614595
102Aplasia/Hypoplasia of the uvula (HP:0010293)1.89454130
103Abnormality of aspartate family amino acid metabolism (HP:0010899)1.88982912
104Premature graying of hair (HP:0002216)1.88773571
105Atresia of the external auditory canal (HP:0000413)1.87690343
106Respiratory difficulties (HP:0002880)1.87469998
107Secondary amenorrhea (HP:0000869)1.86993793
108Optic disc pallor (HP:0000543)1.86702318
109Degeneration of the lateral corticospinal tracts (HP:0002314)1.86483953
110Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.86483953
111Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84766822
112Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.84556195
113Nausea (HP:0002018)1.84437416
114X-linked dominant inheritance (HP:0001423)1.83909677
115Hypomagnesemia (HP:0002917)1.83457487
116Abnormality of methionine metabolism (HP:0010901)1.83095902
117Muscle fiber atrophy (HP:0100295)1.82616379
118Adrenal hypoplasia (HP:0000835)1.82481484
119Metaphyseal cupping (HP:0003021)1.82390779
120Short middle phalanx of the 5th finger (HP:0004220)1.82211806
121Abnormality of the renal medulla (HP:0100957)1.81273967
122Postaxial foot polydactyly (HP:0001830)1.80577157
123Abnormal lung lobation (HP:0002101)1.80471908
124Glioma (HP:0009733)1.80048038
125Bone marrow hypocellularity (HP:0005528)1.79612130
126Lethargy (HP:0001254)1.79139703
127Proximal placement of thumb (HP:0009623)1.78774537
128Chromosomal breakage induced by crosslinking agents (HP:0003221)1.78316799
129Vaginal atresia (HP:0000148)1.77622677
130Lipoatrophy (HP:0100578)1.77515835
131Autoimmune thrombocytopenia (HP:0001973)1.77417496
132Supernumerary spleens (HP:0009799)1.76665861
133Glossoptosis (HP:0000162)1.76511406
134Increased serum pyruvate (HP:0003542)1.76501379
135Bile duct proliferation (HP:0001408)1.76424536
136Abnormal biliary tract physiology (HP:0012439)1.76424536
137Increased density of long bones (HP:0006392)1.75894890
138Optic nerve coloboma (HP:0000588)1.75131218
139Decreased activity of mitochondrial respiratory chain (HP:0008972)1.74968969
140Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.74968969
141Lymphoma (HP:0002665)1.74638922
142Gonadotropin excess (HP:0000837)1.73208099
143Abnormality of the calcaneus (HP:0008364)1.72703924
144Small intestinal stenosis (HP:0012848)1.71465929
145Duodenal stenosis (HP:0100867)1.71465929
146Sloping forehead (HP:0000340)1.71074527
147Astrocytoma (HP:0009592)1.70923934
148Abnormality of the astrocytes (HP:0100707)1.70923934
149Abnormality of glycolysis (HP:0004366)1.70804247
150Bicuspid aortic valve (HP:0001647)1.70440614
151Polyphagia (HP:0002591)1.70107940
152Missing ribs (HP:0000921)1.69487457
153High pitched voice (HP:0001620)1.68686697
154Median cleft lip (HP:0000161)1.68151111
155Ependymoma (HP:0002888)1.67465642
156Biliary tract neoplasm (HP:0100574)1.67167928
157Small hand (HP:0200055)1.67166808
158Increased nuchal translucency (HP:0010880)1.66215905
159Abnormality of the umbilical cord (HP:0010881)1.66108291
160Absent thumb (HP:0009777)1.66103439
161Type 2 muscle fiber atrophy (HP:0003554)1.64474436
162Hypoplasia of the pons (HP:0012110)1.64229552
163Macrocytic anemia (HP:0001972)1.62304195
164Tracheoesophageal fistula (HP:0002575)1.60328699
165Premature ovarian failure (HP:0008209)1.60261283
166Neoplasm of the colon (HP:0100273)1.59521573
167Entropion (HP:0000621)1.59061204
168Melanoma (HP:0002861)1.57862837
169Hypoplasia of the capital femoral epiphysis (HP:0003090)1.57590132
170Ovarian neoplasm (HP:0100615)1.57343917
171Prominent nose (HP:0000448)1.55878155
172Shallow orbits (HP:0000586)1.55841565
173Broad palm (HP:0001169)1.55196297
174Cellular immunodeficiency (HP:0005374)1.54302137
175Prominent metopic ridge (HP:0005487)1.54269040
176Cafe-au-lait spot (HP:0000957)1.53424910
177Rhabdomyolysis (HP:0003201)1.53311930
178Recurrent bronchitis (HP:0002837)1.51720874
179Neoplasm of the adrenal gland (HP:0100631)1.51702783
180Ectopic kidney (HP:0000086)1.51164211
181Pulmonary fibrosis (HP:0002206)1.51046334
182Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.50602037
183Abnormality of alanine metabolism (HP:0010916)1.50602037
184Hyperalaninemia (HP:0003348)1.50602037
185Facial hemangioma (HP:0000329)1.50284213
186Premature rupture of membranes (HP:0001788)1.50160707
187Amaurosis fugax (HP:0100576)1.48914552
188Hypochromic anemia (HP:0001931)1.47903828
189Impulsivity (HP:0100710)1.47535592

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.40752586
2TRIM283.16789648
3WEE13.09594460
4CDC73.00851877
5EIF2AK12.99992574
6MAP4K22.85046401
7BMPR1B2.80719519
8MST42.73491066
9WNK32.69233165
10NEK12.61043030
11NEK22.60534588
12FRK2.28449931
13NME22.27723347
14NUAK12.25218556
15PIM22.22599657
16PBK1.97543265
17SRPK11.94542140
18ACVR1B1.93996441
19EIF2AK31.93797962
20TTK1.79323572
21MKNK11.75218568
22ZAK1.69783416
23TESK21.69466896
24TESK11.67215680
25RPS6KB21.66040702
26TNIK1.64104814
27EEF2K1.63047146
28MAP3K101.56861893
29CASK1.56859195
30RPS6KA41.56237213
31PLK11.54231314
32AURKB1.54081845
33PKN21.53683523
34TSSK61.52529904
35MAP3K41.52223397
36TGFBR11.51267765
37PNCK1.50970320
38BRSK21.46273510
39MAP3K121.45941011
40VRK11.44930369
41PINK11.43079965
42PASK1.42623090
43ATR1.38299369
44DYRK31.38190020
45PLK21.35302603
46STK101.33979352
47PLK41.32763477
48NTRK21.30021633
49MAP4K11.29402657
50STK161.25914307
51PDK21.25554178
52MKNK21.21974385
53CDK71.19234679
54PAK41.19048168
55FLT31.18007887
56CSNK1G11.16083605
57EIF2AK21.15957695
58PLK31.14064652
59MAP3K81.12482211
60KDR1.10969491
61CDK41.10717881
62CDK121.10379206
63TTN1.07791648
64INSRR1.06510196
65SCYL21.05894231
66MARK11.05396280
67VRK21.04128229
68TRIB31.04002330
69MAP2K71.03659876
70CHEK21.02959420
71STK241.00191727
72PIM11.00122087
73LRRK20.96863254
74STK40.95843771
75ADRBK20.95729487
76AURKA0.90846445
77LIMK10.90753616
78EPHA20.90656227
79JAK30.90619059
80CHEK10.89035945
81TAOK20.88089538
82PDK40.87770647
83PDK30.87770647
84CSNK1G30.85454236
85BCR0.84606955
86CAMKK20.84545181
87CSNK1G20.84222123
88MINK10.83985206
89STK38L0.83540845
90ERBB30.82530501
91STK390.80950233
92ZAP700.78668796
93BRAF0.78053201
94NLK0.76231944
95STK30.74485486
96NTRK30.74257997
97NME10.73382033
98MAPK130.73279820
99CDK80.72240123
100CCNB10.72180680
101OXSR10.71553782
102BRSK10.71269609
103PAK10.70284701
104TLK10.69754724
105CSNK1A1L0.69545402
106PRKCG0.69468647
107CDK60.69154540
108PAK20.68980627
109PRKCE0.68766277
110GRK10.68300104
111NEK90.66121677
112ATM0.62646861
113TIE10.61175653
114BTK0.61013107
115ILK0.60392770
116MAPKAPK30.60368339
117PAK30.60278162
118CDK20.59295601
119CSF1R0.58455501
120AKT30.58313173
121TEC0.57752673
122PHKG20.57561537
123PHKG10.57561537
124CHUK0.56222437
125CDK30.55947504
126LATS20.54058220
127TXK0.53197518
128KIT0.51912964
129MAP3K50.51046680
130YES10.49486356
131SIK30.47686240
132FER0.47523257
133DYRK20.46661352
134CSNK1E0.46026075
135PDGFRA0.45113480
136MTOR0.45105779
137MAPKAPK20.45042845
138CSNK2A10.44795025
139RPS6KA50.44395809
140CAMK2A0.43999414
141LATS10.42465804
142CDK10.40417183
143CLK10.40405727
144ERBB40.39196715
145CSNK2A20.39112878
146TYK20.37633217
147AKT20.36972102
148SGK20.36490103
149FGFR10.34474498
150CAMK1G0.33731077
151KSR10.32993956
152PRKG10.32857053
153OBSCN0.32695603
154LMTK20.31467880
155MYLK0.30284348
156CSNK1A10.29756133

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.29221023
2Oxidative phosphorylation_Homo sapiens_hsa001903.42224972
3Mismatch repair_Homo sapiens_hsa034303.24773108
4Proteasome_Homo sapiens_hsa030503.09103169
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97411605
6Ribosome_Homo sapiens_hsa030102.90723352
7Spliceosome_Homo sapiens_hsa030402.90631633
8Base excision repair_Homo sapiens_hsa034102.88066373
9RNA transport_Homo sapiens_hsa030132.80348962
10RNA polymerase_Homo sapiens_hsa030202.62871099
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.60798064
12Cell cycle_Homo sapiens_hsa041102.56550581
13Nucleotide excision repair_Homo sapiens_hsa034202.51100252
14Homologous recombination_Homo sapiens_hsa034402.49246771
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.39351903
16One carbon pool by folate_Homo sapiens_hsa006702.26327230
17Pyrimidine metabolism_Homo sapiens_hsa002402.22705125
18Fatty acid elongation_Homo sapiens_hsa000622.13044501
19Propanoate metabolism_Homo sapiens_hsa006402.05065059
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.04572262
21p53 signaling pathway_Homo sapiens_hsa041151.99991000
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98601141
23Non-homologous end-joining_Homo sapiens_hsa034501.88846310
24Butanoate metabolism_Homo sapiens_hsa006501.86918065
25Steroid biosynthesis_Homo sapiens_hsa001001.83727539
26Alzheimers disease_Homo sapiens_hsa050101.79718375
27RNA degradation_Homo sapiens_hsa030181.77332475
28Fanconi anemia pathway_Homo sapiens_hsa034601.65664206
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.64321496
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56581525
31mRNA surveillance pathway_Homo sapiens_hsa030151.54492093
32Caffeine metabolism_Homo sapiens_hsa002321.54221887
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54134986
34Basal transcription factors_Homo sapiens_hsa030221.51024295
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46483622
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42051574
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.41051400
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.32252097
39Viral myocarditis_Homo sapiens_hsa054161.31212236
40Epstein-Barr virus infection_Homo sapiens_hsa051691.30978535
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16600335
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13631974
43Purine metabolism_Homo sapiens_hsa002301.12445484
44Sulfur metabolism_Homo sapiens_hsa009201.10700248
45Herpes simplex infection_Homo sapiens_hsa051681.10286355
46Small cell lung cancer_Homo sapiens_hsa052221.07867626
47Viral carcinogenesis_Homo sapiens_hsa052031.06500307
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05879356
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.05747011
50Peroxisome_Homo sapiens_hsa041461.04154012
51HTLV-I infection_Homo sapiens_hsa051661.03163966
52Cardiac muscle contraction_Homo sapiens_hsa042601.03082907
53Antigen processing and presentation_Homo sapiens_hsa046121.02086794
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.01930196
55Pyruvate metabolism_Homo sapiens_hsa006201.00667772
56Collecting duct acid secretion_Homo sapiens_hsa049661.00226111
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98018978
58Legionellosis_Homo sapiens_hsa051340.95503341
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94889942
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93740731
61Primary immunodeficiency_Homo sapiens_hsa053400.92801179
62MicroRNAs in cancer_Homo sapiens_hsa052060.88365913
63Systemic lupus erythematosus_Homo sapiens_hsa053220.88210510
64Pentose phosphate pathway_Homo sapiens_hsa000300.88022815
65Regulation of autophagy_Homo sapiens_hsa041400.87770919
66Thyroid cancer_Homo sapiens_hsa052160.86168585
67Metabolic pathways_Homo sapiens_hsa011000.85062470
68Measles_Homo sapiens_hsa051620.83450040
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82607838
70Apoptosis_Homo sapiens_hsa042100.80557011
71Phototransduction_Homo sapiens_hsa047440.79302976
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78745392
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78112351
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77140310
75Tryptophan metabolism_Homo sapiens_hsa003800.76349226
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74796775
77Chronic myeloid leukemia_Homo sapiens_hsa052200.73101552
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.71942595
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71135970
80Allograft rejection_Homo sapiens_hsa053300.70770345
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69331663
82Shigellosis_Homo sapiens_hsa051310.69105679
83Biosynthesis of amino acids_Homo sapiens_hsa012300.68991205
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.68721120
85Hepatitis B_Homo sapiens_hsa051610.67954452
86Chemical carcinogenesis_Homo sapiens_hsa052040.66618194
87Fatty acid metabolism_Homo sapiens_hsa012120.66359135
88Circadian rhythm_Homo sapiens_hsa047100.65846022
89Fat digestion and absorption_Homo sapiens_hsa049750.65807036
90Carbon metabolism_Homo sapiens_hsa012000.65425758
91Oocyte meiosis_Homo sapiens_hsa041140.61727626
92Colorectal cancer_Homo sapiens_hsa052100.61571076
93Selenocompound metabolism_Homo sapiens_hsa004500.60138993
94Fatty acid degradation_Homo sapiens_hsa000710.59978756
95Bladder cancer_Homo sapiens_hsa052190.59730737
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59729020
97Huntingtons disease_Homo sapiens_hsa050160.58596896
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57883334
99Retinol metabolism_Homo sapiens_hsa008300.57722867
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.57186984
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.56732698
102Linoleic acid metabolism_Homo sapiens_hsa005910.56683474
103Hippo signaling pathway_Homo sapiens_hsa043900.55967362
104Acute myeloid leukemia_Homo sapiens_hsa052210.55634241
105Hematopoietic cell lineage_Homo sapiens_hsa046400.55062116
106Ether lipid metabolism_Homo sapiens_hsa005650.54914907
107Nitrogen metabolism_Homo sapiens_hsa009100.54882852
108Nicotine addiction_Homo sapiens_hsa050330.54073846
109Adherens junction_Homo sapiens_hsa045200.53516145
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52198513
111Basal cell carcinoma_Homo sapiens_hsa052170.51827201
112HIF-1 signaling pathway_Homo sapiens_hsa040660.50938134
113beta-Alanine metabolism_Homo sapiens_hsa004100.50713927
114Sulfur relay system_Homo sapiens_hsa041220.50089011
115TGF-beta signaling pathway_Homo sapiens_hsa043500.48323442
116Autoimmune thyroid disease_Homo sapiens_hsa053200.48131339
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47014622
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46732976
119Vitamin B6 metabolism_Homo sapiens_hsa007500.45829358
120Folate biosynthesis_Homo sapiens_hsa007900.45789277
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45326148
122Influenza A_Homo sapiens_hsa051640.45100548
123N-Glycan biosynthesis_Homo sapiens_hsa005100.44545023
124Sphingolipid metabolism_Homo sapiens_hsa006000.44214769
125Pathways in cancer_Homo sapiens_hsa052000.43346485
126Leishmaniasis_Homo sapiens_hsa051400.43112622
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.43041275
128Proteoglycans in cancer_Homo sapiens_hsa052050.42786675
129Notch signaling pathway_Homo sapiens_hsa043300.41295745
130Parkinsons disease_Homo sapiens_hsa050120.41139129
131Pancreatic cancer_Homo sapiens_hsa052120.40771574
132Toxoplasmosis_Homo sapiens_hsa051450.40453271
133Starch and sucrose metabolism_Homo sapiens_hsa005000.40166682
134RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39021642
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.38630919
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.38446226
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37623868
138Vibrio cholerae infection_Homo sapiens_hsa051100.35963682
139Graft-versus-host disease_Homo sapiens_hsa053320.35442612
140Focal adhesion_Homo sapiens_hsa045100.34890476
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34811494
142alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34801294
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34679077
144ECM-receptor interaction_Homo sapiens_hsa045120.34065458
145Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33814514
146Leukocyte transendothelial migration_Homo sapiens_hsa046700.33285720
147Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33225246
148Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31901270
149Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31636685
150T cell receptor signaling pathway_Homo sapiens_hsa046600.31307279
151Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31202256
152Olfactory transduction_Homo sapiens_hsa047400.30669685
153PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30267020
154Protein export_Homo sapiens_hsa030600.30155926
155Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29209452
156B cell receptor signaling pathway_Homo sapiens_hsa046620.29056675
157Glutathione metabolism_Homo sapiens_hsa004800.28980699
158Glycerolipid metabolism_Homo sapiens_hsa005610.27729644
159Alcoholism_Homo sapiens_hsa050340.24764897

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