LZTFL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right axis specification (GO:0070986)5.67725285
2left/right pattern formation (GO:0060972)5.39634947
3cilium or flagellum-dependent cell motility (GO:0001539)5.24187042
4centriole replication (GO:0007099)4.69668739
5centriole assembly (GO:0098534)4.52205159
6microtubule bundle formation (GO:0001578)4.49813797
7protein localization to cilium (GO:0061512)4.35519169
8intraciliary transport (GO:0042073)4.18190390
9axonemal dynein complex assembly (GO:0070286)4.11007409
10presynaptic membrane assembly (GO:0097105)4.10235523
11protein polyglutamylation (GO:0018095)3.96981846
12cilium movement (GO:0003341)3.92044520
13regulation of synaptic vesicle exocytosis (GO:2000300)3.91496939
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.80181800
15epithelial cilium movement (GO:0003351)3.79460904
16synaptic vesicle exocytosis (GO:0016079)3.69111206
17microtubule-based movement (GO:0007018)3.68899746
18presynaptic membrane organization (GO:0097090)3.67462062
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.66843505
20microtubule depolymerization (GO:0007019)3.58490823
21motile cilium assembly (GO:0044458)3.56903100
22transferrin transport (GO:0033572)3.54948919
23neuron cell-cell adhesion (GO:0007158)3.53822403
24axoneme assembly (GO:0035082)3.52437527
25diterpenoid biosynthetic process (GO:0016102)3.46572419
26regulation of synaptic vesicle transport (GO:1902803)3.45795484
27nucleoside diphosphate phosphorylation (GO:0006165)3.43135748
28piRNA metabolic process (GO:0034587)3.42012107
29regulation of microtubule-based movement (GO:0060632)3.41672043
30retinal rod cell development (GO:0046548)3.41135627
31protein localization to synapse (GO:0035418)3.38912555
32cell projection assembly (GO:0030031)3.36680059
33retinal cone cell development (GO:0046549)3.35065808
34long-term synaptic potentiation (GO:0060291)3.34399654
35photoreceptor cell maintenance (GO:0045494)3.33841534
36phagosome maturation (GO:0090382)3.33813245
37trivalent inorganic cation transport (GO:0072512)3.31218240
38ferric iron transport (GO:0015682)3.31218240
39energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.28216284
40ATP hydrolysis coupled proton transport (GO:0015991)3.28216284
41synaptic vesicle docking involved in exocytosis (GO:0016081)3.22384064
42startle response (GO:0001964)3.17853481
43negative regulation of neurotransmitter transport (GO:0051589)3.17851723
44multicellular organism reproduction (GO:0032504)3.15112029
45glutamate secretion (GO:0014047)3.13525697
46negative regulation of neurotransmitter secretion (GO:0046929)3.13013729
47neurotransmitter-gated ion channel clustering (GO:0072578)3.10881553
48nonmotile primary cilium assembly (GO:0035058)3.09168272
49fusion of sperm to egg plasma membrane (GO:0007342)3.06898593
50microtubule polymerization or depolymerization (GO:0031109)3.06447643
51vitamin transmembrane transport (GO:0035461)3.05317170
52gamma-aminobutyric acid signaling pathway (GO:0007214)3.04415003
53calcium ion-dependent exocytosis (GO:0017156)3.03757781
54regulation of cilium movement (GO:0003352)3.02905252
55negative regulation of synaptic transmission, GABAergic (GO:0032229)3.01375260
56neuron-neuron synaptic transmission (GO:0007270)3.00183880
57smoothened signaling pathway (GO:0007224)3.00122257
58positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.99817425
59neuronal action potential propagation (GO:0019227)2.98733155
60acrosome assembly (GO:0001675)2.98444903
61DNA ligation (GO:0006266)2.98356385
62ER overload response (GO:0006983)2.98125305
63negative regulation of dendrite morphogenesis (GO:0050774)2.96421435
64synapsis (GO:0007129)2.94985859
65regulation of DNA endoreduplication (GO:0032875)2.94967600
66protein neddylation (GO:0045116)2.93513820
67lateral ventricle development (GO:0021670)2.92837853
68synaptic transmission, glutamatergic (GO:0035249)2.91009409
69cilium assembly (GO:0042384)2.90856829
70ionotropic glutamate receptor signaling pathway (GO:0035235)2.90230437
71inositol phosphate catabolic process (GO:0071545)2.90002458
72regulation of short-term neuronal synaptic plasticity (GO:0048172)2.89020624
73glutamate receptor signaling pathway (GO:0007215)2.88053694
74reciprocal DNA recombination (GO:0035825)2.87802476
75reciprocal meiotic recombination (GO:0007131)2.87802476
76serotonin receptor signaling pathway (GO:0007210)2.82962073
77sperm motility (GO:0030317)2.82746333
78postsynaptic membrane organization (GO:0001941)2.82120805
79cilium organization (GO:0044782)2.81493624
80acrosome reaction (GO:0007340)2.78800571
81vocalization behavior (GO:0071625)2.78543962
82terpenoid biosynthetic process (GO:0016114)2.77701608
83regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.76369791
84regulation of glutamate receptor signaling pathway (GO:1900449)2.75743372
85primary alcohol catabolic process (GO:0034310)2.74294203
86DNA double-strand break processing (GO:0000729)2.74233199
87regulation of neurotransmitter secretion (GO:0046928)2.73984982
88one-carbon compound transport (GO:0019755)2.71350204
89cell wall macromolecule metabolic process (GO:0044036)2.69284959
90cell wall macromolecule catabolic process (GO:0016998)2.69284959
91lactate metabolic process (GO:0006089)2.68050801
92mechanosensory behavior (GO:0007638)2.67776140
93tongue development (GO:0043586)2.67557017
94cullin deneddylation (GO:0010388)2.66690896
95determination of left/right symmetry (GO:0007368)2.66667866
96organelle assembly (GO:0070925)2.65571967
97striatum development (GO:0021756)2.65019740
98membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.64541542
99determination of bilateral symmetry (GO:0009855)2.62616994
100G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.62334473
101specification of symmetry (GO:0009799)2.61340541
102long-chain fatty acid biosynthetic process (GO:0042759)2.59110826
103cilium morphogenesis (GO:0060271)2.58807961
104retina layer formation (GO:0010842)2.58105520
105aldehyde catabolic process (GO:0046185)2.57219630
106inositol phosphate dephosphorylation (GO:0046855)2.56668780
107phosphorylated carbohydrate dephosphorylation (GO:0046838)2.56668780
108detection of calcium ion (GO:0005513)2.55906326
109regulation of vesicle fusion (GO:0031338)2.55355230
110negative regulation of DNA recombination (GO:0045910)2.54783785
111plasma membrane fusion (GO:0045026)2.54354250
112ribonucleoprotein complex disassembly (GO:0032988)2.53072289
113GPI anchor biosynthetic process (GO:0006506)2.51454615
114regulation of synaptic transmission, glutamatergic (GO:0051966)2.49592582
115negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.49484707
116intra-S DNA damage checkpoint (GO:0031573)2.49182966
117negative regulation of homotypic cell-cell adhesion (GO:0034111)2.48996125
118L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.48695219
119sperm capacitation (GO:0048240)2.48159433
120male meiosis (GO:0007140)2.47854772
121GTP biosynthetic process (GO:0006183)2.47623056
122GPI anchor metabolic process (GO:0006505)2.46864559
123oligosaccharide biosynthetic process (GO:0009312)2.46567539
124regulation of neurotransmitter transport (GO:0051588)2.46504274
125dendrite development (GO:0016358)2.46117286
126limb bud formation (GO:0060174)2.45859862
127photoreceptor cell differentiation (GO:0046530)2.45556308
128eye photoreceptor cell differentiation (GO:0001754)2.45556308
129resolution of meiotic recombination intermediates (GO:0000712)2.45410446
130cerebellar granule cell differentiation (GO:0021707)2.45118493
131positive regulation of synaptic transmission, GABAergic (GO:0032230)2.44914163
132organelle disassembly (GO:1903008)2.44684110
133negative regulation of amino acid transport (GO:0051956)2.43642772
134positive regulation of mitochondrial fission (GO:0090141)2.42508897
135mismatch repair (GO:0006298)2.42135357
136neuronal stem cell maintenance (GO:0097150)2.42099250
137cellular component assembly involved in morphogenesis (GO:0010927)2.41971096
138ventricular system development (GO:0021591)2.41478666
139regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.40234333
140regulation of female gonad development (GO:2000194)2.39725079
141negative regulation of T cell differentiation in thymus (GO:0033085)2.39698446
142regulation of glutamate secretion (GO:0014048)2.38891179
143protein deneddylation (GO:0000338)2.38519799
144regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.38262929
145microtubule-based process (GO:0007017)2.36173163
146signal peptide processing (GO:0006465)2.36031809
147neurotransmitter secretion (GO:0007269)2.35373872
148DNA methylation involved in gamete generation (GO:0043046)2.35171183
149regulation of excitatory postsynaptic membrane potential (GO:0060079)2.35158915
150regulation of synaptic transmission, GABAergic (GO:0032228)2.35130149
151positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.35043491
152positive regulation of cellular amide metabolic process (GO:0034250)2.35036247
153estrogen biosynthetic process (GO:0006703)2.34409078
154RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.33580253
155neural tube formation (GO:0001841)2.30983696
156limb development (GO:0060173)2.30488093
157appendage development (GO:0048736)2.30488093
158forebrain morphogenesis (GO:0048853)2.28885155
159androgen biosynthetic process (GO:0006702)2.28537833
160epithelial cell differentiation involved in kidney development (GO:0035850)2.27686913
161response to pheromone (GO:0019236)2.27544633
162generation of neurons (GO:0048699)2.25409268
163lateral sprouting from an epithelium (GO:0060601)2.24957384
164L-methionine salvage (GO:0071267)2.24688035
165L-methionine biosynthetic process (GO:0071265)2.24688035
166amino acid salvage (GO:0043102)2.24688035
167base-excision repair, AP site formation (GO:0006285)2.23798163
168proteasome assembly (GO:0043248)2.22380973
169regulation of interleukin-13 production (GO:0032656)2.22170205
170radial glial cell differentiation (GO:0060019)2.21790094
171V(D)J recombination (GO:0033151)2.20049293
172establishment of planar polarity (GO:0001736)2.19814186
173establishment of tissue polarity (GO:0007164)2.19814186
174negative regulation of sodium ion transport (GO:0010766)2.18967482
175interkinetic nuclear migration (GO:0022027)2.18168794
176regulation of germinal center formation (GO:0002634)2.17978405
177negative regulation of JUN kinase activity (GO:0043508)2.16816812
178regulation of protein polyubiquitination (GO:1902914)2.16551223
179meiotic cell cycle (GO:0051321)2.16029928
180chromosome organization involved in meiosis (GO:0070192)2.15669143
181retinoic acid metabolic process (GO:0042573)2.14618313
182apical protein localization (GO:0045176)2.14550071

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.92232209
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.76179171
3EZH2_22144423_ChIP-Seq_EOC_Human3.54023506
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.34280295
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.19279113
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.16699054
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.87452053
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.85981330
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.69684987
10TAF15_26573619_Chip-Seq_HEK293_Human2.69260428
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.68376881
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42162327
13VDR_22108803_ChIP-Seq_LS180_Human2.35209984
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25104214
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22927742
16P300_19829295_ChIP-Seq_ESCs_Human2.18781830
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.14525597
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12048288
19FUS_26573619_Chip-Seq_HEK293_Human2.03926785
20SMAD4_21799915_ChIP-Seq_A2780_Human2.00976206
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.94740932
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94563715
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.92547930
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.88410363
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87468543
26AR_21572438_ChIP-Seq_LNCaP_Human1.86877046
27ZNF274_21170338_ChIP-Seq_K562_Hela1.85853068
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.84934396
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83534941
30ER_23166858_ChIP-Seq_MCF-7_Human1.83533892
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81300422
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78557492
33IGF1R_20145208_ChIP-Seq_DFB_Human1.76427912
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.76386455
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.73054105
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72949183
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71714368
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71279182
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.70484053
40RNF2_27304074_Chip-Seq_NSC_Mouse1.70086154
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.67798507
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.67373812
43NANOG_18555785_Chip-Seq_ESCs_Mouse1.65817382
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63837025
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62765005
46REST_21632747_ChIP-Seq_MESCs_Mouse1.61375173
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.60935787
48* GABP_17652178_ChIP-ChIP_JURKAT_Human1.59504887
49EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.55900188
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55114277
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54506209
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50946234
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.50401457
54* ELK1_19687146_ChIP-ChIP_HELA_Human1.50382250
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49606357
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49028136
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48992099
58P53_22387025_ChIP-Seq_ESCs_Mouse1.48746151
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47767121
60* AR_25329375_ChIP-Seq_VCAP_Human1.47501775
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47260669
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46916654
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46280113
64FOXM1_26456572_ChIP-Seq_MCF-7_Human1.46177158
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45022420
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.44526199
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.43108400
68CMYC_18555785_Chip-Seq_ESCs_Mouse1.39545698
69STAT3_23295773_ChIP-Seq_U87_Human1.38448662
70EWS_26573619_Chip-Seq_HEK293_Human1.38355230
71SUZ12_18555785_Chip-Seq_ESCs_Mouse1.38063994
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37275356
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36883947
74E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36777387
75STAT3_18555785_Chip-Seq_ESCs_Mouse1.36279207
76JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35980265
77MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35934326
78* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33992565
79TCF4_23295773_ChIP-Seq_U87_Human1.33388747
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.32924217
81TP53_18474530_ChIP-ChIP_U2OS_Human1.31841735
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31665857
83SOX2_18555785_Chip-Seq_ESCs_Mouse1.31305701
84EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.29761950
85FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29068342
86BP1_19119308_ChIP-ChIP_Hs578T_Human1.29040416
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.28178714
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.27573455
89KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27121598
90RUNX2_22187159_ChIP-Seq_PCA_Human1.25436092
91EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25246936
92RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25246936
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25220572
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24720477
95P300_18555785_Chip-Seq_ESCs_Mouse1.23749315
96KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.22881031
97EST1_17652178_ChIP-ChIP_JURKAT_Human1.21893113
98RNF2_27304074_Chip-Seq_ESCs_Mouse1.21073267
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20740174
100TCF4_22108803_ChIP-Seq_LS180_Human1.20367927
101JUN_21703547_ChIP-Seq_K562_Human1.20319475
102* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18496340
103SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18191248
104RUNX1_27457419_Chip-Seq_LIVER_Mouse1.17916636
105EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17589848
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16411742
107VDR_23849224_ChIP-Seq_CD4+_Human1.16385202
108TBL1_22424771_ChIP-Seq_293T_Human1.15922535
109POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15874907
110NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15799619
111NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15799619
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15746793
113NMYC_18555785_Chip-Seq_ESCs_Mouse1.15488693
114CBP_20019798_ChIP-Seq_JUKART_Human1.15406550
115IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15406550
116EZH2_27294783_Chip-Seq_ESCs_Mouse1.14661192
117* PRDM14_20953172_ChIP-Seq_ESCs_Human1.14084540
118PHF8_20622853_ChIP-Seq_HELA_Human1.13530615
119CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13492455
120BCAT_22108803_ChIP-Seq_LS180_Human1.12941654
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11906649
122* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10898381
123* FOXA1_25329375_ChIP-Seq_VCAP_Human1.10898381
124* KDM2B_26808549_Chip-Seq_REH_Human1.10493413
125RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10253058
126PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.09982309
127NFYB_21822215_ChIP-Seq_K562_Human1.09874418
128PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09516756
129FLI1_21867929_ChIP-Seq_TH2_Mouse1.09495526
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09048037
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09048037
132SOX2_21211035_ChIP-Seq_LN229_Gbm1.09030645
133MYC_18940864_ChIP-ChIP_HL60_Human1.07983375
134ETV1_20927104_ChIP-Seq_GIST48_Human1.07714329
135GATA1_22025678_ChIP-Seq_K562_Human1.07134322
136* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06921916
137HNFA_21074721_ChIP-Seq_CACO-2_Human1.03679937
138IRF1_19129219_ChIP-ChIP_H3396_Human1.03363988
139TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03243061
140CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00609224
141NFYA_21822215_ChIP-Seq_K562_Human0.98281421

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.57205669
2MP0002653_abnormal_ependyma_morphology3.65681780
3MP0009046_muscle_twitch3.14896418
4MP0004859_abnormal_synaptic_plasticity2.97165920
5MP0008875_abnormal_xenobiotic_pharmacok2.90212265
6MP0001968_abnormal_touch/_nociception2.72673604
7MP0002736_abnormal_nociception_after2.68944978
8MP0003635_abnormal_synaptic_transmissio2.67195659
9MP0005646_abnormal_pituitary_gland2.58702570
10MP0004270_analgesia2.55699862
11MP0001986_abnormal_taste_sensitivity2.53302561
12MP0009745_abnormal_behavioral_response2.52809881
13MP0001984_abnormal_olfaction2.51633537
14MP0002064_seizures2.41600347
15MP0002063_abnormal_learning/memory/cond2.36721548
16MP0003787_abnormal_imprinting2.36568401
17MP0005410_abnormal_fertilization2.34777233
18MP0002735_abnormal_chemical_nociception2.34263260
19MP0002734_abnormal_mechanical_nocicepti2.28043492
20MP0008877_abnormal_DNA_methylation2.25877341
21MP0001501_abnormal_sleep_pattern2.22338391
22MP0002572_abnormal_emotion/affect_behav2.21202479
23MP0002272_abnormal_nervous_system2.18223344
24MP0004147_increased_porphyrin_level2.17927925
25MP0003122_maternal_imprinting2.16456298
26MP0006276_abnormal_autonomic_nervous2.16303801
27MP0002876_abnormal_thyroid_physiology2.11909552
28MP0003183_abnormal_peptide_metabolism2.05175562
29MP0009780_abnormal_chondrocyte_physiolo2.02216563
30MP0005645_abnormal_hypothalamus_physiol1.98059731
31MP0001188_hyperpigmentation1.91548730
32MP0001486_abnormal_startle_reflex1.91264563
33MP0002132_abnormal_respiratory_system1.91124030
34MP0008058_abnormal_DNA_repair1.86841642
35MP0001293_anophthalmia1.82049482
36MP0010386_abnormal_urinary_bladder1.80295481
37MP0000383_abnormal_hair_follicle1.80014467
38MP0002067_abnormal_sensory_capabilities1.74295581
39MP0001529_abnormal_vocalization1.71400029
40MP0004133_heterotaxia1.70365497
41MP0005551_abnormal_eye_electrophysiolog1.62103154
42MP0001440_abnormal_grooming_behavior1.58530651
43MP0001905_abnormal_dopamine_level1.56544045
44MP0000778_abnormal_nervous_system1.55610930
45MP0002233_abnormal_nose_morphology1.52988720
46MP0001970_abnormal_pain_threshold1.50791845
47MP0004924_abnormal_behavior1.49800894
48MP0005386_behavior/neurological_phenoty1.49800894
49MP0001502_abnormal_circadian_rhythm1.44385779
50MP0003718_maternal_effect1.43817000
51MP0005389_reproductive_system_phenotype1.43050192
52MP0003879_abnormal_hair_cell1.40807485
53MP0002733_abnormal_thermal_nociception1.40664709
54MP0004142_abnormal_muscle_tone1.40471375
55MP0001346_abnormal_lacrimal_gland1.35560191
56MP0004742_abnormal_vestibular_system1.35556409
57MP0002638_abnormal_pupillary_reflex1.35475563
58MP0002928_abnormal_bile_duct1.33700359
59MP0009697_abnormal_copulation1.33506594
60MP0002184_abnormal_innervation1.31781607
61MP0010094_abnormal_chromosome_stability1.30862097
62MP0002557_abnormal_social/conspecific_i1.30234506
63MP0008057_abnormal_DNA_replication1.30152309
64MP0002938_white_spotting1.28217131
65MP0003937_abnormal_limbs/digits/tail_de1.27504781
66MP0004043_abnormal_pH_regulation1.27435823
67MP0005075_abnormal_melanosome_morpholog1.26112872
68MP0005171_absent_coat_pigmentation1.25934324
69MP0005084_abnormal_gallbladder_morpholo1.24427225
70MP0002822_catalepsy1.21492548
71MP0003938_abnormal_ear_development1.21208222
72MP0002163_abnormal_gland_morphology1.20010207
73MP0005623_abnormal_meninges_morphology1.19937899
74MP0003646_muscle_fatigue1.18773914
75MP0002210_abnormal_sex_determination1.18770473
76MP0010678_abnormal_skin_adnexa1.15724920
77MP0001145_abnormal_male_reproductive1.14984510
78MP0002282_abnormal_trachea_morphology1.14044807
79MP0005391_vision/eye_phenotype1.13883105
80MP0008004_abnormal_stomach_pH1.13662102
81MP0001963_abnormal_hearing_physiology1.11522533
82MP0003890_abnormal_embryonic-extraembry1.09922889
83MP0000653_abnormal_sex_gland1.09917912
84MP0003943_abnormal_hepatobiliary_system1.09497281
85MP0001177_atelectasis1.08870955
86MP0008995_early_reproductive_senescence1.08632758
87MP0003698_abnormal_male_reproductive1.08506712
88MP0005423_abnormal_somatic_nervous1.07880082
89MP0008569_lethality_at_weaning1.04739872
90MP0003121_genomic_imprinting1.04641399
91MP0000372_irregular_coat_pigmentation1.03877389
92MP0006292_abnormal_olfactory_placode1.02050375
93MP0005379_endocrine/exocrine_gland_phen1.01269549
94MP0003136_yellow_coat_color1.00953056
95MP0002882_abnormal_neuron_morphology0.99389749
96MP0005195_abnormal_posterior_eye0.98510976
97MP0000631_abnormal_neuroendocrine_gland0.96761427
98MP0002066_abnormal_motor_capabilities/c0.96432197
99MP0005253_abnormal_eye_physiology0.96157185
100MP0008260_abnormal_autophagy0.95920374
101MP0000569_abnormal_digit_pigmentation0.94983282
102MP0001286_abnormal_eye_development0.93957822
103MP0000566_synostosis0.93153661
104MP0002277_abnormal_respiratory_mucosa0.92172754
105MP0005248_abnormal_Harderian_gland0.91708621
106MP0003633_abnormal_nervous_system0.91655037
107MP0002229_neurodegeneration0.90455402
108MP0000026_abnormal_inner_ear0.89487579
109MP0002148_abnormal_hypersensitivity_rea0.89323965
110MP0009703_decreased_birth_body0.89242212
111MP0001324_abnormal_eye_pigmentation0.87732022
112MP0001485_abnormal_pinna_reflex0.85790070
113MP0000427_abnormal_hair_cycle0.85743825
114MP0004134_abnormal_chest_morphology0.83930357
115MP0002009_preneoplasia0.83822662
116MP0005535_abnormal_body_temperature0.83733235
117MP0000681_abnormal_thyroid_gland0.83227556
118MP0004811_abnormal_neuron_physiology0.80600203
119MP0004782_abnormal_surfactant_physiolog0.80404268
120MP0003861_abnormal_nervous_system0.79393256
121MP0002102_abnormal_ear_morphology0.78819700
122MP0000955_abnormal_spinal_cord0.78338033
123MP0001299_abnormal_eye_distance/0.78227007
124MP0005409_darkened_coat_color0.76809985
125MP0005310_abnormal_salivary_gland0.75489018
126MP0006072_abnormal_retinal_apoptosis0.74866709
127MP0002160_abnormal_reproductive_system0.74811676
128MP0002837_dystrophic_cardiac_calcinosis0.73871144
129MP0002752_abnormal_somatic_nervous0.72623170
130MP0001929_abnormal_gametogenesis0.72451222
131MP0003631_nervous_system_phenotype0.72084606
132MP0005395_other_phenotype0.71683660
133MP0005394_taste/olfaction_phenotype0.69417771
134MP0005499_abnormal_olfactory_system0.69417771
135MP0008872_abnormal_physiological_respon0.69278101
136MP0002234_abnormal_pharynx_morphology0.69234607
137MP0003786_premature_aging0.68966879
138MP0002152_abnormal_brain_morphology0.67825165
139MP0001764_abnormal_homeostasis0.67676795
140MP0002084_abnormal_developmental_patter0.67294846
141MP0002693_abnormal_pancreas_physiology0.67079094
142MP0002249_abnormal_larynx_morphology0.66677769
143MP0002090_abnormal_vision0.63525827
144MP0008789_abnormal_olfactory_epithelium0.63346018
145MP0009250_abnormal_appendicular_skeleto0.63152372
146MP0003195_calcinosis0.62886955
147MP0000920_abnormal_myelination0.62287954
148MP0004885_abnormal_endolymph0.60208767
149MP0004484_altered_response_of0.58487665

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.84001511
2Absent/shortened dynein arms (HP:0200106)5.32908744
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.32908744
4Focal motor seizures (HP:0011153)5.08877176
5Abnormal respiratory motile cilium physiology (HP:0012261)5.00613084
6Abnormal ciliary motility (HP:0012262)4.92435862
7* Medial flaring of the eyebrow (HP:0010747)4.62900100
8Abnormal respiratory epithelium morphology (HP:0012253)4.42502979
9Abnormal respiratory motile cilium morphology (HP:0005938)4.42502979
10* Gait imbalance (HP:0002141)4.35534926
11* Congenital primary aphakia (HP:0007707)4.27207721
12Rhinitis (HP:0012384)4.06873082
13* Nephrogenic diabetes insipidus (HP:0009806)4.01016228
14Abnormal hair whorl (HP:0010721)3.88962337
15Epileptic encephalopathy (HP:0200134)3.68807744
16True hermaphroditism (HP:0010459)3.66859646
17Pancreatic fibrosis (HP:0100732)3.54529781
18* Genital tract atresia (HP:0001827)3.51912304
19Nasal polyposis (HP:0100582)3.48320029
20Febrile seizures (HP:0002373)3.43290517
21* Vaginal atresia (HP:0000148)3.38066076
22Atonic seizures (HP:0010819)3.36853470
23* Poor coordination (HP:0002370)3.32310842
24Hyperventilation (HP:0002883)3.07066612
25Recurrent sinusitis (HP:0011108)2.81405481
26Hypothermia (HP:0002045)2.76973012
27* Aplasia/Hypoplasia of the lens (HP:0008063)2.76593614
28Bronchitis (HP:0012387)2.73541838
29Irregular epiphyses (HP:0010582)2.58044297
30Focal seizures (HP:0007359)2.55980337
31Abnormality of the nasal mucosa (HP:0000433)2.54896529
32Chronic bronchitis (HP:0004469)2.54182685
33Progressive cerebellar ataxia (HP:0002073)2.52718071
34Absence seizures (HP:0002121)2.49384063
35Abnormality of midbrain morphology (HP:0002418)2.48542624
36Molar tooth sign on MRI (HP:0002419)2.48542624
37Pancreatic cysts (HP:0001737)2.47229757
38Nephronophthisis (HP:0000090)2.45115679
39Gaze-evoked nystagmus (HP:0000640)2.45041012
40Sclerocornea (HP:0000647)2.33309595
41Epiphyseal dysplasia (HP:0002656)2.32331777
42Anencephaly (HP:0002323)2.32054396
43Acute necrotizing encephalopathy (HP:0006965)2.30650876
44Recurrent otitis media (HP:0000403)2.27538524
45Dialeptic seizures (HP:0011146)2.27336945
46Abnormality of incisor morphology (HP:0011063)2.24805252
47* Specific learning disability (HP:0001328)2.16536706
48Metaphyseal dysplasia (HP:0100255)2.16043877
49Progressive macrocephaly (HP:0004481)2.15046333
50Aplasia/Hypoplasia of the tongue (HP:0010295)2.14764407
51Vitreoretinal degeneration (HP:0000655)2.14611146
52Pheochromocytoma (HP:0002666)2.14191516
53Male pseudohermaphroditism (HP:0000037)2.13316099
54Central scotoma (HP:0000603)2.11191236
55Broad-based gait (HP:0002136)2.10004189
56Tubulointerstitial nephritis (HP:0001970)2.08729029
57Fibular hypoplasia (HP:0003038)2.07276451
58* Postaxial hand polydactyly (HP:0001162)2.05481797
59Neuroendocrine neoplasm (HP:0100634)2.05113230
60Abnormality of the renal medulla (HP:0100957)2.04414232
61Chronic hepatic failure (HP:0100626)2.03188972
62Postaxial foot polydactyly (HP:0001830)2.02495055
63Abnormal mitochondria in muscle tissue (HP:0008316)2.01731990
64Absent eyebrow (HP:0002223)2.01612752
65Hypokalemic alkalosis (HP:0001949)1.99950703
66Papillary thyroid carcinoma (HP:0002895)1.98983441
67Median cleft lip (HP:0000161)1.97835305
68Decreased central vision (HP:0007663)1.97512394
69Infertility (HP:0000789)1.96756973
70Hyperactive renin-angiotensin system (HP:0000841)1.96741820
71Generalized tonic-clonic seizures (HP:0002069)1.96360694
72Abnormality of the phalanges of the 2nd finger (HP:0009541)1.95453519
73Bronchiectasis (HP:0002110)1.95033107
74Visual hallucinations (HP:0002367)1.94947932
75Protruding tongue (HP:0010808)1.92210274
76Myokymia (HP:0002411)1.90140514
77Aplasia/Hypoplasia of the tibia (HP:0005772)1.89199277
78* Broad foot (HP:0001769)1.89168010
79Retinal dysplasia (HP:0007973)1.89060780
80Furrowed tongue (HP:0000221)1.88533575
81Choroideremia (HP:0001139)1.84149231
82Preaxial hand polydactyly (HP:0001177)1.83298799
83Occipital encephalocele (HP:0002085)1.82605786
84Facial hemangioma (HP:0000329)1.82048020
85Chronic sinusitis (HP:0011109)1.81542305
86Male infertility (HP:0003251)1.76544160
87Fetal akinesia sequence (HP:0001989)1.76312774
88Cone-rod dystrophy (HP:0000548)1.74715908
89Polyphagia (HP:0002591)1.74523633
90Abnormal rod and cone electroretinograms (HP:0008323)1.73126352
91Epileptiform EEG discharges (HP:0011182)1.72651942
92Tubular atrophy (HP:0000092)1.71719960
93Abnormal biliary tract physiology (HP:0012439)1.71518184
94Bile duct proliferation (HP:0001408)1.71518184
95* Short foot (HP:0001773)1.70215843
96Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.69954491
97Blue irides (HP:0000635)1.69832507
98Supernumerary spleens (HP:0009799)1.69460457
99* Asthma (HP:0002099)1.67389241
100Volvulus (HP:0002580)1.66872602
101Esotropia (HP:0000565)1.66310198
102Renal salt wasting (HP:0000127)1.65787980
103Abnormality of the renal cortex (HP:0011035)1.65508450
104Narrow forehead (HP:0000341)1.65124803
105* Multicystic kidney dysplasia (HP:0000003)1.64694868
106* Astigmatism (HP:0000483)1.63998147
107Excessive salivation (HP:0003781)1.62572144
108Drooling (HP:0002307)1.62572144
109Absent speech (HP:0001344)1.62527307
110Abolished electroretinogram (ERG) (HP:0000550)1.62460416
111Poor suck (HP:0002033)1.62379301
112Absent frontal sinuses (HP:0002688)1.60931262
113Bifid tongue (HP:0010297)1.60668879
114Optic disc pallor (HP:0000543)1.60384560
115* Prominent nasal bridge (HP:0000426)1.60351917
116Chronic otitis media (HP:0000389)1.60309363
117Abnormality of macular pigmentation (HP:0008002)1.60149940
118Cystic liver disease (HP:0006706)1.59390437
119Mitochondrial inheritance (HP:0001427)1.58349029
120Small epiphyses (HP:0010585)1.57652862
121Congenital hepatic fibrosis (HP:0002612)1.57186931
122Highly arched eyebrow (HP:0002553)1.55730905
123Thyroid carcinoma (HP:0002890)1.54895432
124Renal dysplasia (HP:0000110)1.54421478
125Limb dystonia (HP:0002451)1.54113159
126Abnormality of the femoral head (HP:0003368)1.53715836
127* Retinitis pigmentosa (HP:0000510)1.53434206
128Reduced antithrombin III activity (HP:0001976)1.52833070
129Oculomotor apraxia (HP:0000657)1.52625480
130Short tibia (HP:0005736)1.52562482
131Dyschromatopsia (HP:0007641)1.52460813
132* Dental crowding (HP:0000678)1.50373463
133* Left ventricular hypertrophy (HP:0001712)1.50139475
134Absent rod-and cone-mediated responses on ERG (HP:0007688)1.48295649
135Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.47051388
136Scotoma (HP:0000575)1.46962690
137* Aganglionic megacolon (HP:0002251)1.44601983
138Hyperinsulinemic hypoglycemia (HP:0000825)1.44408380
139Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.42331123
140Gonadotropin excess (HP:0000837)1.42315037
141Aplasia/Hypoplasia of the spleen (HP:0010451)1.41898010
142Hyperaldosteronism (HP:0000859)1.41776402
143Asplenia (HP:0001746)1.40103513
144Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.39588731
145Tubulointerstitial abnormality (HP:0001969)1.39143812
146Abnormal drinking behavior (HP:0030082)1.37346106
147Polydipsia (HP:0001959)1.37346106
148Large for gestational age (HP:0001520)1.35475546
149Holoprosencephaly (HP:0001360)1.34534030
150Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.34436962
151Overlapping toe (HP:0001845)1.32851712
152Sloping forehead (HP:0000340)1.32153355
153Abnormal glycosylation (HP:0012345)1.31540663
154Abnormal protein N-linked glycosylation (HP:0012347)1.31540663

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.56337338
2RIPK43.15691519
3NTRK32.76492909
4AKT32.53333309
5MAP3K122.47429160
6MAP2K72.46706126
7BMPR22.39673008
8PLK22.36831641
9BMPR1B2.15230173
10WEE12.12636957
11PRPF4B2.10657642
12ERBB32.03514497
13SIK32.00086882
14BCR1.98451801
15EPHA41.96404615
16DAPK21.85201486
17PDK21.85042956
18CDC71.85004697
19PDK41.83179423
20PDK31.83179423
21MKNK11.81531254
22OXSR11.64239751
23SGK21.55877341
24BRSK21.55592517
25MAPK131.55057206
26NEK61.50155223
27TNIK1.49555291
28MAP3K41.48023805
29MAP3K141.46979583
30NLK1.46911241
31PLK41.45939403
32YES11.41021626
33ZAK1.31206073
34TTK1.30563296
35CDK191.27856580
36TAOK31.25480134
37SGK4941.25176786
38SGK2231.25176786
39ADRBK21.23374239
40LATS11.20569578
41MINK11.19434660
42TXK1.19036665
43CCNB11.18504944
44MAP4K21.18053289
45STK38L1.14261608
46MST41.10094502
47STK391.07091365
48PINK11.05131260
49STK241.02975804
50STK31.02872122
51NME11.01191987
52CDK31.01099120
53GRK70.98916297
54PRKCE0.98852473
55PBK0.98042897
56CAMK2A0.97878458
57DAPK10.96296859
58KSR10.95871074
59PTK2B0.95203448
60MAPKAPK50.94792033
61GRK50.93068930
62FGFR20.92448295
63GRK10.91616591
64PLK10.86269466
65NEK20.86175295
66CAMK2B0.85529953
67MARK10.84835523
68PRKD30.84672431
69TLK10.84668071
70BRAF0.82741313
71MAP3K20.81124983
72TRIM280.80740722
73ARAF0.80419857
74ATR0.77829620
75BCKDK0.76266741
76EIF2AK30.76239638
77TAF10.75887320
78DYRK1A0.75835456
79IRAK10.75051897
80PRKCG0.74135499
81MAP3K60.74032113
82PIK3CA0.73263477
83FRK0.71825053
84CAMKK20.71257154
85MAP2K40.70765348
86ATM0.70663516
87CAMK2D0.70054029
88IRAK20.69554207
89NUAK10.68898788
90INSRR0.66794213
91PASK0.65580346
92WNK30.63910868
93IRAK40.63099255
94WNK40.62715438
95CAMK1G0.62653631
96PNCK0.61881946
97CDK50.61360108
98MUSK0.60967412
99NEK10.60883235
100TRPM70.59851873
101SGK30.59507141
102TEC0.58830302
103CHEK20.58161893
104NTRK20.56933092
105FLT30.51714041
106VRK20.50297577
107PLK30.50215808
108MAPK150.49113650
109SGK10.47117779
110MAPK70.45636792
111ADRBK10.44363145
112MAPK100.43527923
113WNK10.43384021
114CSNK1G10.43004779
115CHEK10.41715894
116RPS6KB10.41653081
117TSSK60.41579178
118PRKG10.40782730
119MKNK20.40160755
120TIE10.39289012
121RPS6KA50.38982574
122CAMK2G0.38667549
123PRKACA0.38615257
124SRPK10.37984037
125RPS6KA20.37960025
126AURKB0.37738007
127UHMK10.37676935
128EIF2AK20.37323808
129PKN10.36911441
130MAP3K70.36222552
131CDK60.36100919
132PIK3CG0.35460888
133ERBB40.35080183
134TGFBR10.34725378
135PDK10.34489434
136PAK30.33765090
137CSNK1G20.33434792
138MYLK0.33334648
139VRK10.32775130
140PRKCH0.32589715
141BRSK10.32547619
142CDK80.30609497
143CSNK1A10.29863844

Predicted pathways (KEGG)

RankGene SetZ-score
1Collecting duct acid secretion_Homo sapiens_hsa049663.37258566
2Nicotine addiction_Homo sapiens_hsa050333.22226339
3Synaptic vesicle cycle_Homo sapiens_hsa047213.17975282
4Homologous recombination_Homo sapiens_hsa034402.50205375
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.42264930
6Vibrio cholerae infection_Homo sapiens_hsa051102.39196407
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.33081078
8Non-homologous end-joining_Homo sapiens_hsa034502.28676641
9Rheumatoid arthritis_Homo sapiens_hsa053232.22330655
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.20830677
11Olfactory transduction_Homo sapiens_hsa047402.20142454
12Fanconi anemia pathway_Homo sapiens_hsa034602.10796910
13Taste transduction_Homo sapiens_hsa047422.08982526
14Morphine addiction_Homo sapiens_hsa050322.03381023
15GABAergic synapse_Homo sapiens_hsa047272.02375287
16Oxidative phosphorylation_Homo sapiens_hsa001902.01405489
17Circadian entrainment_Homo sapiens_hsa047131.97957418
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.97498675
19Type I diabetes mellitus_Homo sapiens_hsa049401.97282841
20Amphetamine addiction_Homo sapiens_hsa050311.95607351
21Chemical carcinogenesis_Homo sapiens_hsa052041.94776111
22Phototransduction_Homo sapiens_hsa047441.94474724
23Serotonergic synapse_Homo sapiens_hsa047261.91468229
24Butanoate metabolism_Homo sapiens_hsa006501.91416790
25Protein export_Homo sapiens_hsa030601.84197820
26Nucleotide excision repair_Homo sapiens_hsa034201.80215593
27Long-term potentiation_Homo sapiens_hsa047201.75525972
28Glutamatergic synapse_Homo sapiens_hsa047241.74509269
29Insulin secretion_Homo sapiens_hsa049111.71562808
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.69841370
31Base excision repair_Homo sapiens_hsa034101.69493304
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.63533308
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61298763
34Selenocompound metabolism_Homo sapiens_hsa004501.58173686
35Linoleic acid metabolism_Homo sapiens_hsa005911.58106956
36RNA degradation_Homo sapiens_hsa030181.53872736
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53026868
38Dopaminergic synapse_Homo sapiens_hsa047281.52377021
39Phagosome_Homo sapiens_hsa041451.48948434
40Propanoate metabolism_Homo sapiens_hsa006401.48499324
41beta-Alanine metabolism_Homo sapiens_hsa004101.46836192
42Peroxisome_Homo sapiens_hsa041461.44883755
43Nitrogen metabolism_Homo sapiens_hsa009101.42613679
44Mismatch repair_Homo sapiens_hsa034301.38992706
45Graft-versus-host disease_Homo sapiens_hsa053321.30327169
46Phenylalanine metabolism_Homo sapiens_hsa003601.30027043
47Tyrosine metabolism_Homo sapiens_hsa003501.27874420
48Salivary secretion_Homo sapiens_hsa049701.27839949
49Alzheimers disease_Homo sapiens_hsa050101.27580221
50Renin secretion_Homo sapiens_hsa049241.26661548
51Long-term depression_Homo sapiens_hsa047301.25864387
52Calcium signaling pathway_Homo sapiens_hsa040201.23802488
53Huntingtons disease_Homo sapiens_hsa050161.23020817
54Hedgehog signaling pathway_Homo sapiens_hsa043401.21286114
55Caffeine metabolism_Homo sapiens_hsa002321.18618817
56Cocaine addiction_Homo sapiens_hsa050301.18368534
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17308753
58Steroid hormone biosynthesis_Homo sapiens_hsa001401.16119251
59Cholinergic synapse_Homo sapiens_hsa047251.13914967
60Fatty acid elongation_Homo sapiens_hsa000621.12121682
61Parkinsons disease_Homo sapiens_hsa050121.11150463
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11066712
63Histidine metabolism_Homo sapiens_hsa003401.10238395
64Cysteine and methionine metabolism_Homo sapiens_hsa002701.10022897
65Basal cell carcinoma_Homo sapiens_hsa052171.09863088
66p53 signaling pathway_Homo sapiens_hsa041151.07519109
67Retinol metabolism_Homo sapiens_hsa008301.05476481
68African trypanosomiasis_Homo sapiens_hsa051431.04453414
69Regulation of autophagy_Homo sapiens_hsa041401.03708681
70Allograft rejection_Homo sapiens_hsa053301.03489086
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01306188
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01119804
73RNA transport_Homo sapiens_hsa030130.99833329
74Circadian rhythm_Homo sapiens_hsa047100.94548626
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93971246
76Purine metabolism_Homo sapiens_hsa002300.92855348
77cAMP signaling pathway_Homo sapiens_hsa040240.91334413
78Gastric acid secretion_Homo sapiens_hsa049710.91038065
79Spliceosome_Homo sapiens_hsa030400.90595712
80Steroid biosynthesis_Homo sapiens_hsa001000.90175112
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.89229244
82mRNA surveillance pathway_Homo sapiens_hsa030150.88047853
83DNA replication_Homo sapiens_hsa030300.87980940
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87398982
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87395332
86Oxytocin signaling pathway_Homo sapiens_hsa049210.86289522
87Glutathione metabolism_Homo sapiens_hsa004800.86267228
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85351610
89Basal transcription factors_Homo sapiens_hsa030220.84363351
90Cell cycle_Homo sapiens_hsa041100.82907884
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80254711
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79737166
93Alcoholism_Homo sapiens_hsa050340.79056027
94Autoimmune thyroid disease_Homo sapiens_hsa053200.78165858
95Tryptophan metabolism_Homo sapiens_hsa003800.77301320
96Sphingolipid metabolism_Homo sapiens_hsa006000.76175009
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.75722358
98Ribosome_Homo sapiens_hsa030100.73706301
99Type II diabetes mellitus_Homo sapiens_hsa049300.72195408
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71301557
101Fatty acid degradation_Homo sapiens_hsa000710.70798597
102Dorso-ventral axis formation_Homo sapiens_hsa043200.70512224
103Asthma_Homo sapiens_hsa053100.69445125
104Ether lipid metabolism_Homo sapiens_hsa005650.69243908
105Cardiac muscle contraction_Homo sapiens_hsa042600.68635948
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67935389
107Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67853220
108Tuberculosis_Homo sapiens_hsa051520.66602008
109Legionellosis_Homo sapiens_hsa051340.64820874
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64600281
111Metabolic pathways_Homo sapiens_hsa011000.64485183
112Pyrimidine metabolism_Homo sapiens_hsa002400.63238526
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63117318
114Hippo signaling pathway_Homo sapiens_hsa043900.62152761
115Axon guidance_Homo sapiens_hsa043600.61893069
116RNA polymerase_Homo sapiens_hsa030200.61869405
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61221920
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61064933
119ErbB signaling pathway_Homo sapiens_hsa040120.60349193
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59458675
121MAPK signaling pathway_Homo sapiens_hsa040100.58951811
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58840377
123Sulfur metabolism_Homo sapiens_hsa009200.58132113
124ABC transporters_Homo sapiens_hsa020100.56769329
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55741295
126Pancreatic secretion_Homo sapiens_hsa049720.54744772
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54471116
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54024218
129Mineral absorption_Homo sapiens_hsa049780.53707991
130Salmonella infection_Homo sapiens_hsa051320.53315584
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.53112537
132Gap junction_Homo sapiens_hsa045400.52658501
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52555301
134Inositol phosphate metabolism_Homo sapiens_hsa005620.52508261
135Maturity onset diabetes of the young_Homo sapiens_hsa049500.52131408
136GnRH signaling pathway_Homo sapiens_hsa049120.50849069
137Ras signaling pathway_Homo sapiens_hsa040140.50260265
138Wnt signaling pathway_Homo sapiens_hsa043100.50233728
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48725872
140Malaria_Homo sapiens_hsa051440.47816566
141Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47503902
142Intestinal immune network for IgA production_Homo sapiens_hsa046720.47331884
143N-Glycan biosynthesis_Homo sapiens_hsa005100.46884860
144Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46392587
145Fatty acid metabolism_Homo sapiens_hsa012120.44736724
146Melanogenesis_Homo sapiens_hsa049160.41096587
147Estrogen signaling pathway_Homo sapiens_hsa049150.40296158
148Thyroid hormone synthesis_Homo sapiens_hsa049180.39857968
149Chemokine signaling pathway_Homo sapiens_hsa040620.37636045
150Leishmaniasis_Homo sapiens_hsa051400.37596713
151Ovarian steroidogenesis_Homo sapiens_hsa049130.37187242
152Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36418856
153Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34371330
154Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34144401
155Pertussis_Homo sapiens_hsa051330.32846490
156Arachidonic acid metabolism_Homo sapiens_hsa005900.32551997
157Choline metabolism in cancer_Homo sapiens_hsa052310.32533477
158Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32118130
159Toll-like receptor signaling pathway_Homo sapiens_hsa046200.31839736
160Proteasome_Homo sapiens_hsa030500.30117168
161Oocyte meiosis_Homo sapiens_hsa041140.29387284
162Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29335569
163Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28686521

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