LZTR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mannose metabolic process (GO:0006013)5.98883288
2negative regulation of erythrocyte differentiation (GO:0045647)5.19181848
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.12892350
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.05641263
5synaptic vesicle maturation (GO:0016188)4.90456592
6semaphorin-plexin signaling pathway (GO:0071526)4.64498596
7glutamate secretion (GO:0014047)4.61290861
8locomotory exploration behavior (GO:0035641)4.60533626
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.40895071
10synaptic vesicle exocytosis (GO:0016079)4.28366589
11positive regulation of synapse maturation (GO:0090129)4.25500116
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.19193132
13vocalization behavior (GO:0071625)4.18981352
14regulation of synaptic vesicle exocytosis (GO:2000300)4.09034511
15deoxyribonucleoside diphosphate metabolic process (GO:0009186)4.04582262
16regulation of synaptic vesicle transport (GO:1902803)4.03776783
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.01877197
18synaptic transmission, glutamatergic (GO:0035249)3.89418783
19protein retention in ER lumen (GO:0006621)3.78180716
20deoxyribonucleotide biosynthetic process (GO:0009263)3.74819281
21regulation of ARF GTPase activity (GO:0032312)3.74343133
22regulation of glutamate receptor signaling pathway (GO:1900449)3.70746455
23protein localization to synapse (GO:0035418)3.66545083
24regulation of neuronal synaptic plasticity (GO:0048168)3.66507370
25basement membrane organization (GO:0071711)3.60544220
26neurotransmitter secretion (GO:0007269)3.54983750
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.54557287
28regulation of synapse maturation (GO:0090128)3.53138949
29exploration behavior (GO:0035640)3.50249028
30negative regulation of cell size (GO:0045792)3.47530406
31proline transport (GO:0015824)3.47093426
32maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.43742912
33regulation of autophagic vacuole assembly (GO:2000785)3.40471758
34neuron cell-cell adhesion (GO:0007158)3.38096836
35Golgi transport vesicle coating (GO:0048200)3.35989935
36COPI coating of Golgi vesicle (GO:0048205)3.35989935
37regulation of synapse structural plasticity (GO:0051823)3.35601261
38ionotropic glutamate receptor signaling pathway (GO:0035235)3.34345660
39adherens junction assembly (GO:0034333)3.33596306
40planar cell polarity pathway involved in neural tube closure (GO:0090179)3.30112331
41regulation of early endosome to late endosome transport (GO:2000641)3.29196778
42neuronal action potential propagation (GO:0019227)3.28199141
43neuron-neuron synaptic transmission (GO:0007270)3.27397034
44positive regulation of protein kinase C signaling (GO:0090037)3.27123537
45cell-substrate junction assembly (GO:0007044)3.18171872
46cell-substrate adherens junction assembly (GO:0007045)3.16157045
47focal adhesion assembly (GO:0048041)3.16157045
48protein localization to endosome (GO:0036010)3.15432341
49adenosine receptor signaling pathway (GO:0001973)3.13777855
50UV protection (GO:0009650)3.13069807
51positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.11638681
52positive regulation of protein dephosphorylation (GO:0035307)3.06785581
53regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.05870164
54cytoskeletal anchoring at plasma membrane (GO:0007016)3.05566115
55stress fiber assembly (GO:0043149)3.05104009
56positive regulation of membrane potential (GO:0045838)3.03111905
57positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.01619076
58GDP-mannose metabolic process (GO:0019673)3.01564985
59regulation of centriole replication (GO:0046599)3.01356517
60layer formation in cerebral cortex (GO:0021819)3.00706616
61barbed-end actin filament capping (GO:0051016)3.00512188
62negative regulation of microtubule polymerization (GO:0031115)2.99976796
63long-term memory (GO:0007616)2.99111816
64retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.97989264
65cell-cell junction maintenance (GO:0045217)2.96771606
66synaptic vesicle endocytosis (GO:0048488)2.96730055
67regulation of synaptic plasticity (GO:0048167)2.92400491
68activation of JUN kinase activity (GO:0007257)2.92137725
69neurotransmitter transport (GO:0006836)2.90809934
70apoptotic process involved in morphogenesis (GO:0060561)2.88760226
71regulation of histone H3-K27 methylation (GO:0061085)2.88269684
72neuromuscular process controlling balance (GO:0050885)2.86192094
73regulation of protein kinase A signaling (GO:0010738)2.85565117
74negative regulation of fatty acid transport (GO:2000192)2.85382408
75negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.84661910
76regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.84409920
77regulation of extracellular matrix disassembly (GO:0010715)2.82848375
78receptor recycling (GO:0001881)2.82281828
79regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.81806448
80proline biosynthetic process (GO:0006561)2.80359600
81regulation of neurotransmitter secretion (GO:0046928)2.79956545
82glutamate receptor signaling pathway (GO:0007215)2.79459443
83protein carboxylation (GO:0018214)2.78599254
84peptidyl-glutamic acid carboxylation (GO:0017187)2.78599254
85innervation (GO:0060384)2.78442976
86regulation of excitatory postsynaptic membrane potential (GO:0060079)2.78149552
87endocytic recycling (GO:0032456)2.76857911
88endothelial cell chemotaxis (GO:0035767)2.76473804
89axonal fasciculation (GO:0007413)2.75507461
90positive regulation of blood vessel endothelial cell migration (GO:0043536)2.75460481
91negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.75169333
92ribosome assembly (GO:0042255)2.75057997
93transmission of nerve impulse (GO:0019226)2.72448038
94histone H4 deacetylation (GO:0070933)2.71552982
95histone arginine methylation (GO:0034969)2.71427844
96calcium ion-dependent exocytosis (GO:0017156)2.71355549
97peptidyl-arginine omega-N-methylation (GO:0035247)2.71222233
98atrioventricular valve morphogenesis (GO:0003181)2.70919422
99regulation of ARF protein signal transduction (GO:0032012)2.70585016
100protein heterotrimerization (GO:0070208)2.70437459
101negative regulation of dendrite morphogenesis (GO:0050774)2.70083677
102dendritic spine morphogenesis (GO:0060997)2.69688271
103spliceosomal snRNP assembly (GO:0000387)2.69372465
104activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.68779908
105neuron recognition (GO:0008038)2.67773807
106DNA deamination (GO:0045006)2.67685560
107startle response (GO:0001964)2.67453153
108establishment of integrated proviral latency (GO:0075713)2.67414011
109cell volume homeostasis (GO:0006884)2.66548971
110protein complex localization (GO:0031503)2.65492272
111vesicle docking involved in exocytosis (GO:0006904)2.64886616
112vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.64347559
113neuromuscular synaptic transmission (GO:0007274)2.63730957
114ribosome biogenesis (GO:0042254)2.63486572
115activation of Rac GTPase activity (GO:0032863)2.62699172
116response to laminar fluid shear stress (GO:0034616)2.62551201
117hemidesmosome assembly (GO:0031581)2.62058838
118regulation of postsynaptic membrane potential (GO:0060078)2.60719364
119tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.60461800
120RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.60461800
121long-term synaptic potentiation (GO:0060291)2.59963060
122positive regulation of receptor recycling (GO:0001921)2.59804801
123regulation of neurotransmitter levels (GO:0001505)2.58532010
124cell communication by electrical coupling (GO:0010644)2.58517894
125gamma-aminobutyric acid transport (GO:0015812)2.58320069
126mitochondrion transport along microtubule (GO:0047497)2.58259409
127establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.58259409
128negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.56317680
129regulation of vesicle fusion (GO:0031338)2.54938557
130membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.54910528
131positive regulation of muscle cell apoptotic process (GO:0010661)2.54847586
132neurotransmitter-gated ion channel clustering (GO:0072578)2.54696024
133retrograde transport, endosome to Golgi (GO:0042147)2.53833257
134dendritic spine organization (GO:0097061)2.53693718
135regulation of oxidative phosphorylation (GO:0002082)2.52949649
136regulation of mitochondrial translation (GO:0070129)2.52940231
137cellular potassium ion homeostasis (GO:0030007)2.52669060
138dendrite morphogenesis (GO:0048813)2.52569488
139positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.51188672
140regulation of vacuole organization (GO:0044088)2.51026939
141neuromuscular process (GO:0050905)2.50992343
1422-deoxyribonucleotide biosynthetic process (GO:0009265)2.50769268
143deoxyribose phosphate biosynthetic process (GO:0046385)2.50769268
144negative regulation of dendrite development (GO:2000171)2.50638428
145modulation by symbiont of host cellular process (GO:0044068)2.50120844
146regulation of neurotransmitter transport (GO:0051588)2.49758587
147positive regulation of nuclease activity (GO:0032075)2.49518054
148deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.49401774
149forebrain morphogenesis (GO:0048853)2.49035514
150cell migration in hindbrain (GO:0021535)2.48115244
151peptidyl-arginine N-methylation (GO:0035246)2.47667918
152peptidyl-arginine methylation (GO:0018216)2.47667918
153modulation by virus of host process (GO:0019054)2.47298911
154regulation of dendritic spine morphogenesis (GO:0061001)2.47233641
155actin filament bundle organization (GO:0061572)2.46465552
156actin filament bundle assembly (GO:0051017)2.46465552
157establishment of mitochondrion localization (GO:0051654)2.46325837
158vascular endothelial growth factor signaling pathway (GO:0038084)2.45995998
159cell migration involved in gastrulation (GO:0042074)2.45857823
160transcription elongation from RNA polymerase III promoter (GO:0006385)2.45711721
161termination of RNA polymerase III transcription (GO:0006386)2.45711721
162regulation of mammary gland epithelial cell proliferation (GO:0033599)2.45631899
163positive regulation of histone deacetylation (GO:0031065)2.44884271
164response to muramyl dipeptide (GO:0032495)2.41007392
165apoptotic cell clearance (GO:0043277)2.40992473
166insulin-like growth factor receptor signaling pathway (GO:0048009)2.40685718
167protein targeting to plasma membrane (GO:0072661)2.40104192
168regulation of type I interferon-mediated signaling pathway (GO:0060338)2.39724534
169regulation of cholesterol biosynthetic process (GO:0045540)2.39716335
170regulation of hydrogen peroxide metabolic process (GO:0010310)2.38077282
171actin filament depolymerization (GO:0030042)2.37338265
172regulation of glucose import in response to insulin stimulus (GO:2001273)2.36882611
173chondroitin sulfate catabolic process (GO:0030207)2.36461518
174cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.36254844
175regulation of cholesterol metabolic process (GO:0090181)2.33898736
176skin morphogenesis (GO:0043589)2.28934672
177epithelial cell differentiation involved in prostate gland development (GO:0060742)2.27996297
178histone H3 deacetylation (GO:0070932)2.27576942
179regulation of cholesterol homeostasis (GO:2000188)2.26815631
180regulation of NFAT protein import into nucleus (GO:0051532)2.26523730
181activation of MAPKKK activity (GO:0000185)2.26383030
182regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.26228917
183negative regulation of granulocyte differentiation (GO:0030853)2.25496017
184low-density lipoprotein particle clearance (GO:0034383)2.25103746
185cortical actin cytoskeleton organization (GO:0030866)2.23845343
186negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.23382722
187maternal placenta development (GO:0001893)2.22858874
188stress granule assembly (GO:0034063)2.21682989
189regulation of nuclease activity (GO:0032069)2.21157591
190positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.20402607
191cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.20128865
192Rho protein signal transduction (GO:0007266)2.19713266
193regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.18888534
194thymic T cell selection (GO:0045061)2.17981805
195adhesion of symbiont to host (GO:0044406)2.16015740
196response to fluid shear stress (GO:0034405)2.15460101

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.17243312
2LXR_22292898_ChIP-Seq_THP-1_Human3.21524922
3VDR_21846776_ChIP-Seq_THP-1_Human3.19152081
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.95092201
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.92820494
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.73123594
7ELK3_25401928_ChIP-Seq_HUVEC_Human2.64096948
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.61786370
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.58053513
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.54948174
11KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.49395541
12MYC_22102868_ChIP-Seq_BL_Human2.47859776
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.43861083
14REST_21632747_ChIP-Seq_MESCs_Mouse2.43046417
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.37363764
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35622095
17RACK7_27058665_Chip-Seq_MCF-7_Human2.32724046
18* RARB_27405468_Chip-Seq_BRAIN_Mouse2.30488667
19KDM2B_26808549_Chip-Seq_DND41_Human2.30236682
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.30136505
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.28632593
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.19979039
23* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.17354178
24* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11653952
25KDM2B_26808549_Chip-Seq_K562_Human2.10526327
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.10492809
27TCF7_22412390_ChIP-Seq_EML_Mouse2.09054032
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05644674
29* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.04069736
30* ETS1_20019798_ChIP-Seq_JURKAT_Human2.03763955
31STAT6_21828071_ChIP-Seq_BEAS2B_Human2.02682597
32P68_20966046_ChIP-Seq_HELA_Human2.00402851
33* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97370686
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.92464819
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.87548895
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86778635
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.85876034
38DROSHA_22980978_ChIP-Seq_HELA_Human1.83269883
39CTCF_27219007_Chip-Seq_ERYTHROID_Human1.78707281
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.77584281
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.77359655
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.76945112
43SA1_27219007_Chip-Seq_ERYTHROID_Human1.74862223
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.74533818
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74357430
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74178906
47UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.71397608
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.71347454
49SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.70565882
50GBX2_23144817_ChIP-Seq_PC3_Human1.70509101
51RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.69570800
52SMC4_20622854_ChIP-Seq_HELA_Human1.68239920
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.66333016
54MAF_26560356_Chip-Seq_TH2_Human1.65605980
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.65273786
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.65093593
57* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.63462091
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62772244
59RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.62328948
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61855103
61VDR_24763502_ChIP-Seq_THP-1_Human1.61841585
62SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.61063649
63HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60722350
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59931535
65* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59527649
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58602805
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58140260
68RNF2_18974828_ChIP-Seq_MESCs_Mouse1.56581550
69EZH2_18974828_ChIP-Seq_MESCs_Mouse1.56581550
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.55017518
71JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54164334
72CTCF_27219007_Chip-Seq_Bcells_Human1.53688989
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.53563355
74GABP_17652178_ChIP-ChIP_JURKAT_Human1.52775274
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52216256
76MAF_26560356_Chip-Seq_TH1_Human1.51609099
77CREB1_26743006_Chip-Seq_LNCaP_Human1.51139595
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50171751
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49079952
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48404175
81NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48108983
82TP53_22127205_ChIP-Seq_IMR90_Human1.47771603
83MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46891447
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.46095721
85* NCOR1_26117541_ChIP-Seq_K562_Human1.45227972
86* XRN2_22483619_ChIP-Seq_HELA_Human1.44840384
87ELF1_20517297_ChIP-Seq_JURKAT_Human1.44254321
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43310721
89SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43113535
90BCOR_27268052_Chip-Seq_Bcells_Human1.42560752
91CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.41008033
92SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.40344557
93SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39050466
94MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.38937200
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38016543
96RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36725255
97SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36445891
98SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.35121757
99BCL6_27268052_Chip-Seq_Bcells_Human1.34861987
100ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34162320
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33813423
102NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32907826
103MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32504692
104UTX_26944678_Chip-Seq_JUKART_Human1.31373840
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30635997
106E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28025138
107CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.27499061
108IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27165000
109EGR1_19374776_ChIP-ChIP_THP-1_Human1.25907767
110CLOCK_20551151_ChIP-Seq_293T_Human1.25062949
111EZH2_27294783_Chip-Seq_ESCs_Mouse1.24558564
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24528544
113ZNF274_21170338_ChIP-Seq_K562_Hela1.24408739
114SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24370808
115MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23711818
116EED_16625203_ChIP-ChIP_MESCs_Mouse1.23023466
117EZH2_27304074_Chip-Seq_ESCs_Mouse1.22565060
118MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22561883
119SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22021220
120KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20019955
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18776638
122NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18215809
123* RARB_24833708_ChIP-Seq_LIVER_Mouse1.18208281
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17960682
125* RUNX1_22412390_ChIP-Seq_EML_Mouse1.17884857
126SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17575374
127PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17499446
128SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.17297875
129ZNF263_19887448_ChIP-Seq_K562_Human1.16981826
130MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15706375
131ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15518242
132* RARA_24833708_ChIP-Seq_LIVER_Mouse1.15479458
133TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14723416
134PHF8_20622854_ChIP-Seq_HELA_Human1.13998123
135CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13916718
136NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.13206793
137RUNX1_27514584_Chip-Seq_MCF-7_Human1.12751900
138ATF3_27146783_Chip-Seq_COLON_Human1.11625067
139DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10405136
140E2F1_20622854_ChIP-Seq_HELA_Human1.10190466
141RNF2_27304074_Chip-Seq_ESCs_Mouse1.10040211
142E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09985319
143GATA1_19941827_ChIP-Seq_MEL_Mouse1.09794260
144ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09467925
145SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08755885
146CTCF_21964334_Chip-Seq_Bcells_Human1.07845639
147UBF1/2_26484160_Chip-Seq_HMECs_Human1.07601783
148TP63_22573176_ChIP-Seq_HFKS_Human1.07401482
149CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05975019
150CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05693260
151GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05379070
152CTCF_21964334_ChIP-Seq_BJAB-B_Human1.05233788
153RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05007498
154SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04909595
155SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04727743
156SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03899097
157SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03800264
158BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03122925
159ETS1_21867929_ChIP-Seq_TH2_Mouse1.02879667
160POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02809007
161TET1_21490601_ChIP-Seq_MESCs_Mouse1.01830615
162GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01167321
163TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01093948
164TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01058370
165OCT4_19829295_ChIP-Seq_ESCs_Human1.01043811
166SA1_27219007_Chip-Seq_Bcells_Human1.00640263
167GABP_19822575_ChIP-Seq_HepG2_Human1.00195188
168* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99707922
169CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98145715
170PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98123661
171CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.97163074
172KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96827219
173SOX2_16153702_ChIP-ChIP_HESCs_Human0.96302760
174TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95463420
175MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94341214
176FOXP1_21924763_ChIP-Seq_HESCs_Human0.91625009
177SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.90403622
178PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90179392
179NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90172489
180VDR_23849224_ChIP-Seq_CD4+_Human0.89907708
181YY1_22570637_ChIP-Seq_MALME-3M_Human0.89864719
182ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88701731
183TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.88609068
184CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87502171

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.08049810
2MP0003705_abnormal_hypodermis_morpholog5.47949779
3MP0008438_abnormal_cutaneous_collagen4.05877830
4MP0003880_abnormal_central_pattern3.63271455
5MP0004270_analgesia3.62520797
6MP0005058_abnormal_lysosome_morphology3.61397972
7MP0003635_abnormal_synaptic_transmissio3.51710110
8MP0005409_darkened_coat_color3.04842202
9MP0003172_abnormal_lysosome_physiology2.98154547
10MP0001968_abnormal_touch/_nociception2.94615257
11MP0002063_abnormal_learning/memory/cond2.84823927
12MP0009745_abnormal_behavioral_response2.82809277
13MP0003279_aneurysm2.80474516
14MP0001958_emphysema2.71406312
15MP0002734_abnormal_mechanical_nocicepti2.69071919
16MP0000751_myopathy2.68034530
17MP0002736_abnormal_nociception_after2.53931939
18MP0001849_ear_inflammation2.47434584
19MP0002735_abnormal_chemical_nociception2.47159103
20MP0002064_seizures2.46807947
21MP0004858_abnormal_nervous_system2.30300149
22MP0009046_muscle_twitch2.28045039
23MP0009840_abnormal_foam_cell2.26274040
24MP0003566_abnormal_cell_adhesion2.20602157
25MP0002572_abnormal_emotion/affect_behav2.20485503
26MP0002272_abnormal_nervous_system2.17829447
27MP0005423_abnormal_somatic_nervous2.16919309
28MP0003091_abnormal_cell_migration2.11057268
29MP0003123_paternal_imprinting2.07577937
30MP0005451_abnormal_body_composition2.03123055
31MP0002822_catalepsy2.01049315
32MP0000003_abnormal_adipose_tissue1.99390182
33MP0002249_abnormal_larynx_morphology1.98900645
34MP0005503_abnormal_tendon_morphology1.96747555
35MP0003283_abnormal_digestive_organ1.96593100
36MP0009278_abnormal_bone_marrow1.94209273
37MP0003453_abnormal_keratinocyte_physiol1.88793122
38MP0005076_abnormal_cell_differentiation1.86488160
39MP0008260_abnormal_autophagy1.85597276
40MP0001486_abnormal_startle_reflex1.80942184
41MP0004811_abnormal_neuron_physiology1.78604169
42MP0002733_abnormal_thermal_nociception1.78506463
43MP0005257_abnormal_intraocular_pressure1.77447023
44MP0002184_abnormal_innervation1.76666240
45MP0001348_abnormal_lacrimal_gland1.76270007
46MP0000013_abnormal_adipose_tissue1.76193862
47MP0000778_abnormal_nervous_system1.69922085
48MP0001970_abnormal_pain_threshold1.66978795
49MP0004133_heterotaxia1.63370873
50MP0004272_abnormal_basement_membrane1.62521006
51MP0001440_abnormal_grooming_behavior1.60616387
52MP0000955_abnormal_spinal_cord1.60285734
53MP0005386_behavior/neurological_phenoty1.59780410
54MP0004924_abnormal_behavior1.59780410
55MP0009384_cardiac_valve_regurgitation1.59416936
56MP0004381_abnormal_hair_follicle1.58573503
57MP0003303_peritoneal_inflammation1.57489100
58MP0006276_abnormal_autonomic_nervous1.55345028
59MP0003436_decreased_susceptibility_to1.54278956
60MP0008569_lethality_at_weaning1.52136514
61MP0002067_abnormal_sensory_capabilities1.50905025
62MP0005375_adipose_tissue_phenotype1.48956480
63MP0000767_abnormal_smooth_muscle1.48105804
64MP0008877_abnormal_DNA_methylation1.41707104
65MP0009780_abnormal_chondrocyte_physiolo1.41436868
66MP0003329_amyloid_beta_deposits1.41187271
67MP0001905_abnormal_dopamine_level1.40900202
68MP0001501_abnormal_sleep_pattern1.40846529
69MP0003879_abnormal_hair_cell1.39435126
70MP0002060_abnormal_skin_morphology1.38408903
71MP0003191_abnormal_cellular_cholesterol1.38360596
72MP0002877_abnormal_melanocyte_morpholog1.37582901
73MP0005499_abnormal_olfactory_system1.36001432
74MP0005394_taste/olfaction_phenotype1.36001432
75MP0005023_abnormal_wound_healing1.35683166
76MP0000747_muscle_weakness1.34904103
77MP0001177_atelectasis1.33812438
78MP0002557_abnormal_social/conspecific_i1.33515738
79MP0006292_abnormal_olfactory_placode1.33285690
80MP0002160_abnormal_reproductive_system1.32479523
81MP0005275_abnormal_skin_tensile1.32268615
82MP0002933_joint_inflammation1.32183845
83MP0003890_abnormal_embryonic-extraembry1.29610685
84MP0003300_gastrointestinal_ulcer1.28629223
85MP0002882_abnormal_neuron_morphology1.28504416
86MP0002066_abnormal_motor_capabilities/c1.25705698
87MP0005666_abnormal_adipose_tissue1.25636737
88MP0001986_abnormal_taste_sensitivity1.25073097
89MP0005083_abnormal_biliary_tract1.22305203
90MP0001188_hyperpigmentation1.21695194
91MP0004185_abnormal_adipocyte_glucose1.21549755
92MP0004885_abnormal_endolymph1.21522894
93MP0000534_abnormal_ureter_morphology1.19732188
94MP0005174_abnormal_tail_pigmentation1.18483259
95MP0004947_skin_inflammation1.17050365
96MP0003787_abnormal_imprinting1.16358204
97MP0010030_abnormal_orbit_morphology1.15230323
98MP0002909_abnormal_adrenal_gland1.15045901
99MP0004142_abnormal_muscle_tone1.13942255
100MP0002751_abnormal_autonomic_nervous1.13791484
101MP0000733_abnormal_muscle_development1.11698871
102MP0002152_abnormal_brain_morphology1.11651784
103MP0000750_abnormal_muscle_regeneration1.10816850
104MP0000858_altered_metastatic_potential1.09865502
105MP0002653_abnormal_ependyma_morphology1.08607935
106MP0000759_abnormal_skeletal_muscle1.06816763
107MP0000015_abnormal_ear_pigmentation1.05248964
108MP0010386_abnormal_urinary_bladder1.03786699
109MP0003119_abnormal_digestive_system1.02290533
110MP0004043_abnormal_pH_regulation1.01740486
111MP0004130_abnormal_muscle_cell1.01097200
112MP0003111_abnormal_nucleus_morphology1.00784168
113MP0001529_abnormal_vocalization1.00274650
114MP0001502_abnormal_circadian_rhythm1.00156195
115MP0003690_abnormal_glial_cell0.98061757
116MP0002876_abnormal_thyroid_physiology0.95667951
117MP0002998_abnormal_bone_remodeling0.95661870
118MP0000537_abnormal_urethra_morphology0.95413311
119MP0001661_extended_life_span0.94260677
120MP0003861_abnormal_nervous_system0.93139766
121MP0001299_abnormal_eye_distance/0.92207384
122MP0003632_abnormal_nervous_system0.90838324
123MP0005389_reproductive_system_phenotype0.90297129
124MP0005330_cardiomyopathy0.89180157
125MP0005646_abnormal_pituitary_gland0.88801476
126MP0008872_abnormal_physiological_respon0.87815992
127MP0008789_abnormal_olfactory_epithelium0.86860557
128MP0005508_abnormal_skeleton_morphology0.86052493
129MP0004087_abnormal_muscle_fiber0.86027539
130MP0009931_abnormal_skin_appearance0.85514951
131MP0003121_genomic_imprinting0.85278952
132MP0002896_abnormal_bone_mineralization0.85106893
133MP0003136_yellow_coat_color0.84687842
134MP0000678_abnormal_parathyroid_gland0.83275050
135MP0006138_congestive_heart_failure0.83159831
136MP0004510_myositis0.82571547
137MP0003631_nervous_system_phenotype0.81340993
138MP0008932_abnormal_embryonic_tissue0.81075993
139MP0003385_abnormal_body_wall0.81002810
140MP0005621_abnormal_cell_physiology0.80575288
141MP0002069_abnormal_eating/drinking_beha0.80521297
142MP0004233_abnormal_muscle_weight0.79847230
143MP0003122_maternal_imprinting0.79641961
144MP0002752_abnormal_somatic_nervous0.78213607
145MP0001485_abnormal_pinna_reflex0.75872492
146MP0001963_abnormal_hearing_physiology0.75725839
147MP0001243_abnormal_dermal_layer0.74133733
148MP0003942_abnormal_urinary_system0.72260673
149MP0010630_abnormal_cardiac_muscle0.72021471
150MP0003693_abnormal_embryo_hatching0.72014082
151MP0005171_absent_coat_pigmentation0.72000265
152MP0001984_abnormal_olfaction0.71821935
153MP0000604_amyloidosis0.71689186
154MP0005623_abnormal_meninges_morphology0.71333384
155MP0004957_abnormal_blastocyst_morpholog0.70952597
156MP0001614_abnormal_blood_vessel0.70180002
157MP0003315_abnormal_perineum_morphology0.69320124
158MP0005501_abnormal_skin_physiology0.68625084
159MP0002089_abnormal_postnatal_growth/wei0.68569036
160MP0000681_abnormal_thyroid_gland0.68315424
161MP0002229_neurodegeneration0.68216973
162MP0003448_altered_tumor_morphology0.68038187
163MP0005187_abnormal_penis_morphology0.67872457
164MP0002108_abnormal_muscle_morphology0.67446968
165MP0002234_abnormal_pharynx_morphology0.66421454
166MP0003634_abnormal_glial_cell0.65065521
167MP0006035_abnormal_mitochondrial_morpho0.64982686
168MP0003633_abnormal_nervous_system0.64105843
169MP0005390_skeleton_phenotype0.64051926
170MP0003115_abnormal_respiratory_system0.64038333
171MP0003045_fibrosis0.63991918
172MP0002925_abnormal_cardiovascular_devel0.63945335
173MP0000631_abnormal_neuroendocrine_gland0.63519978
174MP0003077_abnormal_cell_cycle0.62205272
175MP0005397_hematopoietic_system_phenotyp0.60600194
176MP0001545_abnormal_hematopoietic_system0.60600194
177MP0001270_distended_abdomen0.60586299
178MP0010769_abnormal_survival0.59763193
179MP0002932_abnormal_joint_morphology0.59244396
180MP0008874_decreased_physiological_sensi0.58861835
181MP0001943_abnormal_respiration0.58438375
182MP0005595_abnormal_vascular_smooth0.58333158
183MP0001533_abnormal_skeleton_physiology0.58060960
184MP0001915_intracranial_hemorrhage0.57984313
185MP0005670_abnormal_white_adipose0.57961936
186MP0010368_abnormal_lymphatic_system0.57014554
187MP0002970_abnormal_white_adipose0.56384223

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.99835883
2Thin bony cortex (HP:0002753)4.46402361
3Progressive external ophthalmoplegia (HP:0000590)4.34260787
4Focal motor seizures (HP:0011153)4.20804910
5Protrusio acetabuli (HP:0003179)4.10993656
6Ulnar bowing (HP:0003031)3.90925404
7Abnormality of the lower motor neuron (HP:0002366)3.88192839
8Premature rupture of membranes (HP:0001788)3.66490155
9Cerebral aneurysm (HP:0004944)3.63920190
10Focal seizures (HP:0007359)3.38434905
11Cervical subluxation (HP:0003308)3.35300205
12Visual hallucinations (HP:0002367)3.24704057
13Cerebral hypomyelination (HP:0006808)3.24359114
14Turricephaly (HP:0000262)3.23515986
15Epileptic encephalopathy (HP:0200134)3.18700930
16Fetal akinesia sequence (HP:0001989)3.17355010
17Obstructive sleep apnea (HP:0002870)3.01818046
18Insomnia (HP:0100785)3.01449921
19Distal upper limb amyotrophy (HP:0007149)3.00287205
20Upper limb amyotrophy (HP:0009129)3.00287205
21Joint stiffness (HP:0001387)2.90103637
22Shallow orbits (HP:0000586)2.88375942
23Progressive cerebellar ataxia (HP:0002073)2.86740447
24Broad face (HP:0000283)2.86467711
25Broad-based gait (HP:0002136)2.81403870
26Ankle clonus (HP:0011448)2.77837235
27Biconcave vertebral bodies (HP:0004586)2.76642968
28Disproportionate tall stature (HP:0001519)2.68807010
29Carpal bone hypoplasia (HP:0001498)2.67311765
30Hemorrhage of the eye (HP:0011885)2.66832214
31Stridor (HP:0010307)2.62859538
32Distal lower limb amyotrophy (HP:0008944)2.60902463
33Atonic seizures (HP:0010819)2.59311168
34Increased connective tissue (HP:0009025)2.57237361
35Delusions (HP:0000746)2.56530281
36Bladder diverticulum (HP:0000015)2.55282965
37Atrophic scars (HP:0001075)2.51177336
38Febrile seizures (HP:0002373)2.49922034
39Action tremor (HP:0002345)2.49541170
40Thin ribs (HP:0000883)2.49149510
41Mitral regurgitation (HP:0001653)2.48866052
42Absence seizures (HP:0002121)2.45495548
43Poor eye contact (HP:0000817)2.44399109
44Supranuclear gaze palsy (HP:0000605)2.42571106
45Impaired vibration sensation in the lower limbs (HP:0002166)2.41741832
46Vertebral compression fractures (HP:0002953)2.41666314
47Atelectasis (HP:0100750)2.41544528
48Dysostosis multiplex (HP:0000943)2.40722698
49Urinary glycosaminoglycan excretion (HP:0003541)2.39046099
50Mucopolysacchariduria (HP:0008155)2.39046099
51Elfin facies (HP:0004428)2.37067507
52Colon cancer (HP:0003003)2.36852281
53Broad metatarsal (HP:0001783)2.36528728
54External ophthalmoplegia (HP:0000544)2.35006076
55Abnormality of polysaccharide metabolism (HP:0011012)2.34573204
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.34573204
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.34573204
58Anxiety (HP:0000739)2.33441822
59Unsteady gait (HP:0002317)2.32861709
60Hand muscle atrophy (HP:0009130)2.32507587
61Fragile skin (HP:0001030)2.32167590
62Dilatation of the ascending aorta (HP:0005111)2.28496855
63Postural instability (HP:0002172)2.28020185
64Genu recurvatum (HP:0002816)2.27708185
65Neoplasm of the adrenal cortex (HP:0100641)2.27274056
66Truncus arteriosus (HP:0001660)2.27127236
67Birth length less than 3rd percentile (HP:0003561)2.23818905
68Amyotrophic lateral sclerosis (HP:0007354)2.23647182
69Spinal rigidity (HP:0003306)2.23027208
70Overriding aorta (HP:0002623)2.22553082
71Bradykinesia (HP:0002067)2.22429071
72Spinal muscular atrophy (HP:0007269)2.22336167
73Dialeptic seizures (HP:0011146)2.21057806
74Increased variability in muscle fiber diameter (HP:0003557)2.20703207
75Aortic aneurysm (HP:0004942)2.20167786
76Epileptiform EEG discharges (HP:0011182)2.18917102
77Hyperacusis (HP:0010780)2.18785926
78Bowel diverticulosis (HP:0005222)2.15645159
79Blue sclerae (HP:0000592)2.15424538
80Renal duplication (HP:0000075)2.15356422
81Abnormality of the labia minora (HP:0012880)2.15310381
82Proximal tubulopathy (HP:0000114)2.15001707
83Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.14854841
84Impaired smooth pursuit (HP:0007772)2.14596512
85Flat cornea (HP:0007720)2.13428199
86Breast hypoplasia (HP:0003187)2.11883037
87EEG with generalized epileptiform discharges (HP:0011198)2.11780652
88Pointed chin (HP:0000307)2.10895778
89Hypsarrhythmia (HP:0002521)2.09627155
90Aneurysm (HP:0002617)2.09354464
91Bowed forearm bones (HP:0003956)2.09014964
92Bowing of the arm (HP:0006488)2.09014964
93Wormian bones (HP:0002645)2.06773030
94Abnormal eating behavior (HP:0100738)2.06747829
95J-shaped sella turcica (HP:0002680)2.05432827
96Urinary urgency (HP:0000012)2.04846102
97Atrophy/Degeneration involving motor neurons (HP:0007373)2.02448956
98Vascular tortuosity (HP:0004948)2.01532931
99Fibular aplasia (HP:0002990)1.99783824
100Gout (HP:0001997)1.98904362
101CNS hypomyelination (HP:0003429)1.98556980
102Achilles tendon contracture (HP:0001771)1.97625097
103Generalized tonic-clonic seizures (HP:0002069)1.97238985
104Impaired social interactions (HP:0000735)1.96933758
105Abnormal social behavior (HP:0012433)1.96933758
106Glioma (HP:0009733)1.96703578
107Myopathic facies (HP:0002058)1.96461266
108Lower limb amyotrophy (HP:0007210)1.95830304
109Increased circulating renin level (HP:0000848)1.95280138
110Mildly elevated creatine phosphokinase (HP:0008180)1.94760510
111Urinary bladder sphincter dysfunction (HP:0002839)1.94481965
112Focal dystonia (HP:0004373)1.93730715
113Arterial tortuosity (HP:0005116)1.92962769
114Coronal craniosynostosis (HP:0004440)1.91174634
115Renovascular hypertension (HP:0100817)1.90849467
116Akinesia (HP:0002304)1.90463914
117Spastic gait (HP:0002064)1.89936845
118Annular pancreas (HP:0001734)1.89219868
119Emphysema (HP:0002097)1.88226639
120Torticollis (HP:0000473)1.87789636
121Hypertensive crisis (HP:0100735)1.87233436
122Hyperthyroidism (HP:0000836)1.87079372
123Gaze-evoked nystagmus (HP:0000640)1.84630827
124Truncal ataxia (HP:0002078)1.84196769
125Shoulder girdle muscle weakness (HP:0003547)1.84152860
126Premature skin wrinkling (HP:0100678)1.84028252
127Mitral valve prolapse (HP:0001634)1.83152846
128Difficulty climbing stairs (HP:0003551)1.82562473
129Aortic dissection (HP:0002647)1.81710180
130Nuclear cataract (HP:0100018)1.80649730
131Mutism (HP:0002300)1.79723790
132Lymphangioma (HP:0100764)1.79471284
133Aortic regurgitation (HP:0001659)1.79294874
134Abnormality of pain sensation (HP:0010832)1.79288386
135Impaired pain sensation (HP:0007328)1.79288386
136Long palpebral fissure (HP:0000637)1.79038639
137Dislocated radial head (HP:0003083)1.78067674
138Abnormality of skeletal muscle fiber size (HP:0012084)1.77076021
139Joint laxity (HP:0001388)1.75630094
140Abnormality of ocular smooth pursuit (HP:0000617)1.75415684
141Easy fatigability (HP:0003388)1.75108945
142Nonimmune hydrops fetalis (HP:0001790)1.74374278
143Limb dystonia (HP:0002451)1.73746154
144Depression (HP:0000716)1.73192930
145Hydroureter (HP:0000072)1.72552261
146Dysmetria (HP:0001310)1.72269430
147Craniofacial dystonia (HP:0012179)1.72247645
148Bowel incontinence (HP:0002607)1.71617139
149Abnormality of the Achilles tendon (HP:0005109)1.71507777
150Colitis (HP:0002583)1.71450759
151Pheochromocytoma (HP:0002666)1.71043512
152Glucose intolerance (HP:0000833)1.69950317
153Venous abnormality (HP:0002624)1.69825723
154Protruding tongue (HP:0010808)1.69787447
155Rectal prolapse (HP:0002035)1.69429350
156Aplasia/Hypoplasia of the brainstem (HP:0007362)1.69134679
157Hypoplasia of the brainstem (HP:0002365)1.69134679
158Hypertriglyceridemia (HP:0002155)1.68765090
159Cerebral inclusion bodies (HP:0100314)1.68003269
160Asymmetric septal hypertrophy (HP:0001670)1.68003031
161Neurofibrillary tangles (HP:0002185)1.67375572
162Hyperventilation (HP:0002883)1.66715710
163Patellar dislocation (HP:0002999)1.66251047
164Elbow flexion contracture (HP:0002987)1.66045143
165Breast aplasia (HP:0100783)1.65810564
166Metaphyseal cupping (HP:0003021)1.64828541
167Ankyloglossia (HP:0010296)1.64260174
168Progressive muscle weakness (HP:0003323)1.63278584
169Ectopia lentis (HP:0001083)1.62682138
170Reticulocytosis (HP:0001923)1.62642699
171Peritonitis (HP:0002586)1.62386433
172Abnormality of the astrocytes (HP:0100707)1.62136748
173Astrocytoma (HP:0009592)1.62136748
174Supernumerary nipples (HP:0002558)1.62056560
175Flat acetabular roof (HP:0003180)1.61876516
176Cholecystitis (HP:0001082)1.61782484
177Abnormal gallbladder physiology (HP:0012438)1.61782484
178Amblyopia (HP:0000646)1.60944746
179Abnormality of the radial head (HP:0003995)1.60748295
180Rib fusion (HP:0000902)1.59928522
181Septo-optic dysplasia (HP:0100842)1.59423332
182Gait ataxia (HP:0002066)1.58574909
183Abnormality of the thoracic spine (HP:0100711)1.58553203
184Abnormality of magnesium homeostasis (HP:0004921)1.57985726
185Abnormality of the aortic arch (HP:0012303)1.57180930
186Abnormality of the corticospinal tract (HP:0002492)1.56691948
187Testicular atrophy (HP:0000029)1.55564154
188Ulnar claw (HP:0001178)1.54793531
189Disproportionate short-trunk short stature (HP:0003521)1.54681943
190Insidious onset (HP:0003587)1.54479588
191Termporal pattern (HP:0011008)1.54479588
192Incomplete penetrance (HP:0003829)1.54292277
193Aplasia/hypoplasia of the uterus (HP:0008684)1.53241020

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.24791238
2TRIB34.98683335
3PLK43.72199869
4NTRK33.15177952
5MAP3K93.09227518
6EPHA43.08997720
7ERN12.89004000
8ICK2.79496477
9IRAK32.72383768
10SIK12.70931825
11PINK12.69276094
12MAPK152.48041487
13BUB12.45769683
14CDK192.43981028
15LATS22.31624471
16MINK12.30530863
17RIPK12.30353142
18EEF2K2.26840146
19PRPF4B2.17918713
20SMG12.13198487
21MAP2K31.95529246
22PDGFRA1.88353236
23MAP3K41.86203271
24FGFR41.85206952
25PNCK1.83515135
26SRPK11.78488855
27CDK121.70931539
28TTN1.68728594
29PKN21.68500224
30NTRK11.60146134
31MARK21.60071714
32PRKD21.58425172
33PAK61.57674212
34PLK21.55645886
35MAP3K131.55368149
36MAP3K61.55168010
37SIK21.54746743
38KSR21.52821504
39DAPK21.49965291
40IRAK21.45753260
41MAP2K71.43941730
42TSSK61.43526839
43PRKD31.39372121
44SCYL21.38169068
45STK381.38124578
46CAMKK11.37971152
47RIPK41.37934557
48DAPK11.37356923
49BRSK11.36518326
50PLK31.34498963
51EPHB11.24543514
52ZAK1.22362079
53ARAF1.22108513
54ZAP701.20153683
55WEE11.19885252
56BLK1.17913253
57PTK21.17149785
58PTK61.16965833
59AKT31.16224206
60CDK51.13835054
61MTOR1.13824366
62RPS6KA21.13580831
63PRKCG1.12421743
64NEK61.09397594
65PDPK11.07523891
66MAPK121.06728907
67TYRO31.03572195
68CASK1.02169410
69NEK10.99287539
70MAP4K10.97575679
71TYK20.94920348
72BMX0.93540185
73MAP3K110.92872519
74PRKCI0.91560230
75MAP3K70.89626988
76KSR10.89540804
77MAP3K100.89282209
78MAP2K40.88277089
79MST1R0.87952062
80NME10.87852540
81NME20.86962525
82IRAK10.86562918
83MAP3K10.86209800
84SGK4940.85419806
85SGK2230.85419806
86STK38L0.85377357
87TNK20.84980447
88MAP3K120.84838163
89NTRK20.83228038
90CAMK2B0.83101945
91TESK20.82267130
92TBK10.81726668
93UHMK10.81394832
94GRK60.78667812
95OXSR10.78401751
96RET0.75504096
97BRAF0.74890473
98MAPK130.74453549
99MAP3K30.74144016
100CAMK1D0.73640025
101BRSK20.73465416
102PAK40.73361320
103CDK180.73205045
104RPS6KC10.73190004
105RPS6KL10.73190004
106CDK150.72675110
107ALK0.72520567
108CAMKK20.71668390
109MAPK110.71160358
110CDK11A0.70814934
111JAK30.70726386
112MAP3K20.68828915
113EPHB20.68416160
114CDK140.68083357
115STK160.67925190
116EIF2AK10.67781057
117EPHA20.66955797
118TAOK20.65764521
119CDK40.65590430
120BMPR20.65217977
121LIMK10.64992587
122CSK0.64965277
123PDGFRB0.64681586
124CAMK1G0.64580203
125VRK10.64479943
126CDC42BPA0.63329655
127WNK10.61483414
128PLK10.61405680
129DYRK1B0.59974305
130MAPK70.58313302
131GRK50.57776962
132PAK20.57756452
133PRKD10.57263116
134ERBB30.57112941
135TTK0.56294192
136RAF10.55405534
137TAOK10.55120960
138WNK40.54881614
139HIPK20.54874227
140DYRK20.53283979
141TESK10.52964819
142FGFR30.52902206
143RPS6KA60.52900022
144MET0.52000456
145CAMK2A0.50594911
146PDK10.50560874
147LRRK20.49899091
148AURKA0.48256985
149CSNK1E0.47645798
150SGK20.46969435
151DDR20.46756507
152SIK30.46511615
153CAMK2G0.45926881
154MAP3K80.45391489
155CSNK1G20.45355635
156MAP2K10.45253226
157ILK0.45070202
158FES0.44749678
159MAP3K140.44431886
160BTK0.42724895
161SGK30.41705835
162WNK30.41600350
163MAPK80.41111965
164MOS0.40707797
165JAK10.40483077
166MAPK100.39113874
167HCK0.38873893
168TGFBR20.38716952
169ATR0.38682258
170DYRK1A0.37583931
171MAP2K60.36173982
172ABL20.35624720
173ROCK20.35549290
174CDC70.35161052
175PRKDC0.33690562
176PTK2B0.33515524
177CAMK2D0.33292874
178PRKCZ0.32260061

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.84981132
2Other glycan degradation_Homo sapiens_hsa005113.48817974
3Nicotine addiction_Homo sapiens_hsa050333.44507885
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.57686118
5RNA polymerase_Homo sapiens_hsa030202.38864178
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.38049886
7Proteasome_Homo sapiens_hsa030502.26527838
8Long-term potentiation_Homo sapiens_hsa047202.25892586
9Olfactory transduction_Homo sapiens_hsa047402.23644403
10Circadian entrainment_Homo sapiens_hsa047132.17230181
11Amphetamine addiction_Homo sapiens_hsa050312.12977507
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.07779502
13Glutamatergic synapse_Homo sapiens_hsa047242.04854584
14GABAergic synapse_Homo sapiens_hsa047271.99624553
15Notch signaling pathway_Homo sapiens_hsa043301.98526688
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.90707655
17VEGF signaling pathway_Homo sapiens_hsa043701.88095703
18Collecting duct acid secretion_Homo sapiens_hsa049661.88046978
19Morphine addiction_Homo sapiens_hsa050321.79778402
20Oocyte meiosis_Homo sapiens_hsa041141.77668700
21Chronic myeloid leukemia_Homo sapiens_hsa052201.76519590
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.75022694
23Dopaminergic synapse_Homo sapiens_hsa047281.74278294
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73885765
25Acute myeloid leukemia_Homo sapiens_hsa052211.73608529
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.73252373
27Fructose and mannose metabolism_Homo sapiens_hsa000511.71904475
28Insulin secretion_Homo sapiens_hsa049111.71703450
29DNA replication_Homo sapiens_hsa030301.68180116
30Sulfur relay system_Homo sapiens_hsa041221.59134570
31Spliceosome_Homo sapiens_hsa030401.53965579
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.50131061
33Non-small cell lung cancer_Homo sapiens_hsa052231.47544096
34Taste transduction_Homo sapiens_hsa047421.46728128
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46414282
36Pyrimidine metabolism_Homo sapiens_hsa002401.45007814
37Gastric acid secretion_Homo sapiens_hsa049711.42835895
38Bladder cancer_Homo sapiens_hsa052191.42573547
39Mismatch repair_Homo sapiens_hsa034301.38676756
40Cholinergic synapse_Homo sapiens_hsa047251.38363025
41Salivary secretion_Homo sapiens_hsa049701.37780149
42mTOR signaling pathway_Homo sapiens_hsa041501.36506263
43Focal adhesion_Homo sapiens_hsa045101.35191840
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27703009
45ECM-receptor interaction_Homo sapiens_hsa045121.27534555
46Vibrio cholerae infection_Homo sapiens_hsa051101.25450240
47Central carbon metabolism in cancer_Homo sapiens_hsa052301.24251170
48RNA transport_Homo sapiens_hsa030131.22953191
49Pancreatic cancer_Homo sapiens_hsa052121.21779857
50Serotonergic synapse_Homo sapiens_hsa047261.20421717
51Long-term depression_Homo sapiens_hsa047301.18660891
52SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17141099
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17070574
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16890772
55Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16465527
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15346505
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.15323197
58Lysosome_Homo sapiens_hsa041421.15098367
59Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15065676
60Cocaine addiction_Homo sapiens_hsa050301.14568929
61GnRH signaling pathway_Homo sapiens_hsa049121.13164838
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13127842
63Inositol phosphate metabolism_Homo sapiens_hsa005621.12500563
64Insulin signaling pathway_Homo sapiens_hsa049101.12090321
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09864767
66Gap junction_Homo sapiens_hsa045401.08278603
67Parkinsons disease_Homo sapiens_hsa050121.08062887
68Oxidative phosphorylation_Homo sapiens_hsa001901.07909235
69Oxytocin signaling pathway_Homo sapiens_hsa049211.05507542
70Cardiac muscle contraction_Homo sapiens_hsa042601.05172942
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04628945
72B cell receptor signaling pathway_Homo sapiens_hsa046621.03192038
73Calcium signaling pathway_Homo sapiens_hsa040201.02075848
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01924099
75Osteoclast differentiation_Homo sapiens_hsa043800.99996134
76Huntingtons disease_Homo sapiens_hsa050160.99643274
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98776386
78Purine metabolism_Homo sapiens_hsa002300.97944366
79Choline metabolism in cancer_Homo sapiens_hsa052310.96586383
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.94382129
81Axon guidance_Homo sapiens_hsa043600.94093014
82Renal cell carcinoma_Homo sapiens_hsa052110.93818990
83Prolactin signaling pathway_Homo sapiens_hsa049170.93146939
84Amoebiasis_Homo sapiens_hsa051460.90900223
85Lysine degradation_Homo sapiens_hsa003100.90892169
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.90370311
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88426011
88Glioma_Homo sapiens_hsa052140.87069046
89Insulin resistance_Homo sapiens_hsa049310.86953743
90AMPK signaling pathway_Homo sapiens_hsa041520.86901801
91Proteoglycans in cancer_Homo sapiens_hsa052050.86262948
92Melanogenesis_Homo sapiens_hsa049160.85263869
93Small cell lung cancer_Homo sapiens_hsa052220.84910673
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82793895
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82094757
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80206778
97TNF signaling pathway_Homo sapiens_hsa046680.79810829
98Hepatitis C_Homo sapiens_hsa051600.78962279
99Toxoplasmosis_Homo sapiens_hsa051450.78670844
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78370463
101Alzheimers disease_Homo sapiens_hsa050100.78225782
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.75304559
103Hepatitis B_Homo sapiens_hsa051610.74211836
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74053150
105One carbon pool by folate_Homo sapiens_hsa006700.73687158
106Type II diabetes mellitus_Homo sapiens_hsa049300.72508711
107Pancreatic secretion_Homo sapiens_hsa049720.72236512
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.71582369
109Estrogen signaling pathway_Homo sapiens_hsa049150.71439552
110Galactose metabolism_Homo sapiens_hsa000520.71313796
111Colorectal cancer_Homo sapiens_hsa052100.71009447
112Renin secretion_Homo sapiens_hsa049240.70784548
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70184679
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.69170320
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69135352
116ErbB signaling pathway_Homo sapiens_hsa040120.68113911
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67759455
118MicroRNAs in cancer_Homo sapiens_hsa052060.67397781
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67204026
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65690223
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65629830
122Platelet activation_Homo sapiens_hsa046110.64821613
123Thyroid hormone synthesis_Homo sapiens_hsa049180.63578991
124Hippo signaling pathway_Homo sapiens_hsa043900.63134223
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63034869
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63016410
127Sphingolipid metabolism_Homo sapiens_hsa006000.62938901
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62536279
129Dilated cardiomyopathy_Homo sapiens_hsa054140.62251670
130Prostate cancer_Homo sapiens_hsa052150.61663187
131Phenylalanine metabolism_Homo sapiens_hsa003600.61295655
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59726305
133Apoptosis_Homo sapiens_hsa042100.58346058
134Pertussis_Homo sapiens_hsa051330.57773532
135HIF-1 signaling pathway_Homo sapiens_hsa040660.57711893
136Alcoholism_Homo sapiens_hsa050340.57485553
137Pentose phosphate pathway_Homo sapiens_hsa000300.56907611
138Salmonella infection_Homo sapiens_hsa051320.56543876
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.56197518
140Fanconi anemia pathway_Homo sapiens_hsa034600.56012550
141Ribosome_Homo sapiens_hsa030100.55040047
142Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53620769
143Thyroid cancer_Homo sapiens_hsa052160.52388630
144mRNA surveillance pathway_Homo sapiens_hsa030150.50601055
145Pathways in cancer_Homo sapiens_hsa052000.50216658
146Shigellosis_Homo sapiens_hsa051310.50176190
147RNA degradation_Homo sapiens_hsa030180.49937689
148HTLV-I infection_Homo sapiens_hsa051660.49068155
149Neurotrophin signaling pathway_Homo sapiens_hsa047220.47941731
150Influenza A_Homo sapiens_hsa051640.47504001
151Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47241622
152Type I diabetes mellitus_Homo sapiens_hsa049400.47225728
153cAMP signaling pathway_Homo sapiens_hsa040240.46899311
154Phospholipase D signaling pathway_Homo sapiens_hsa040720.46883682
155Tuberculosis_Homo sapiens_hsa051520.46231170
156Adherens junction_Homo sapiens_hsa045200.46032670
157T cell receptor signaling pathway_Homo sapiens_hsa046600.45370921
158Prion diseases_Homo sapiens_hsa050200.44888616
159Endometrial cancer_Homo sapiens_hsa052130.44693139
160Wnt signaling pathway_Homo sapiens_hsa043100.44393424
161Base excision repair_Homo sapiens_hsa034100.43203966
162Hedgehog signaling pathway_Homo sapiens_hsa043400.42738288
163Biosynthesis of amino acids_Homo sapiens_hsa012300.40875180
164Melanoma_Homo sapiens_hsa052180.40574648
165Tight junction_Homo sapiens_hsa045300.39235437
166MAPK signaling pathway_Homo sapiens_hsa040100.38926899
167Cell cycle_Homo sapiens_hsa041100.38526982
168Rap1 signaling pathway_Homo sapiens_hsa040150.38405546
169Homologous recombination_Homo sapiens_hsa034400.37591231
170Epstein-Barr virus infection_Homo sapiens_hsa051690.36908416
171Vascular smooth muscle contraction_Homo sapiens_hsa042700.36290625
172Endocytosis_Homo sapiens_hsa041440.35427441

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »