LZTS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)7.82026906
2melanin metabolic process (GO:0006582)7.03776163
3secondary metabolite biosynthetic process (GO:0044550)6.62166625
4presynaptic membrane assembly (GO:0097105)6.10251726
5presynaptic membrane organization (GO:0097090)5.56200107
6postsynaptic membrane organization (GO:0001941)5.48732001
7neuron cell-cell adhesion (GO:0007158)5.45519160
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.40268057
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.32280692
10neurotransmitter-gated ion channel clustering (GO:0072578)5.05307359
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.97770259
12vocalization behavior (GO:0071625)4.97349026
13protein localization to synapse (GO:0035418)4.94960375
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.71878191
15negative regulation of dendrite morphogenesis (GO:0050774)4.56582694
16synaptic vesicle exocytosis (GO:0016079)4.56104637
17neuronal action potential propagation (GO:0019227)4.48916438
18regulation of glutamate receptor signaling pathway (GO:1900449)4.46235217
19positive regulation of neurotransmitter secretion (GO:0001956)4.45351916
20glutamate secretion (GO:0014047)4.28526135
21negative regulation of dendrite development (GO:2000171)4.20259978
22regulation of synaptic vesicle exocytosis (GO:2000300)4.11420064
23regulation of short-term neuronal synaptic plasticity (GO:0048172)4.04220683
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.03462251
25regulation of glutamate secretion (GO:0014048)3.98435684
26synaptic transmission, glutamatergic (GO:0035249)3.97836014
27neuron-neuron synaptic transmission (GO:0007270)3.92143061
28cerebral cortex radially oriented cell migration (GO:0021799)3.86114340
29glutamate receptor signaling pathway (GO:0007215)3.82191294
30mechanosensory behavior (GO:0007638)3.75512643
31pyrimidine nucleobase catabolic process (GO:0006208)3.70682643
32positive regulation of neurotransmitter transport (GO:0051590)3.69515019
33regulation of excitatory postsynaptic membrane potential (GO:0060079)3.69069086
34regulation of synaptic vesicle transport (GO:1902803)3.67595562
35negative regulation of synaptic transmission, GABAergic (GO:0032229)3.67429128
36dendritic spine morphogenesis (GO:0060997)3.65640030
37neuron recognition (GO:0008038)3.64164447
38enteric nervous system development (GO:0048484)3.62889599
39layer formation in cerebral cortex (GO:0021819)3.58375220
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.57778479
41positive regulation of synapse assembly (GO:0051965)3.55456503
42regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.54555898
43regulation of postsynaptic membrane potential (GO:0060078)3.51209760
44gamma-aminobutyric acid signaling pathway (GO:0007214)3.50124371
45serotonin receptor signaling pathway (GO:0007210)3.48172049
46auditory behavior (GO:0031223)3.45765977
47positive regulation of membrane potential (GO:0045838)3.45231094
48long-term synaptic potentiation (GO:0060291)3.44491604
49regulation of respiratory system process (GO:0044065)3.44098909
50axonal fasciculation (GO:0007413)3.43424384
51limb bud formation (GO:0060174)3.42922707
52startle response (GO:0001964)3.42601124
53regulation of neuronal synaptic plasticity (GO:0048168)3.42326712
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.40932410
55cell migration in hindbrain (GO:0021535)3.40807196
56cerebellar granule cell differentiation (GO:0021707)3.37754401
57neuromuscular synaptic transmission (GO:0007274)3.36501877
58proline transport (GO:0015824)3.35246471
59positive regulation of dendritic spine morphogenesis (GO:0061003)3.32329732
60regulation of synapse structural plasticity (GO:0051823)3.32287095
61regulation of long-term neuronal synaptic plasticity (GO:0048169)3.31793453
62response to histamine (GO:0034776)3.30115297
63melanocyte differentiation (GO:0030318)3.29986301
64sympathetic nervous system development (GO:0048485)3.29007908
65regulation of neurotransmitter secretion (GO:0046928)3.28495714
66regulation of synapse maturation (GO:0090128)3.27334040
67regulation of synaptic transmission, glutamatergic (GO:0051966)3.23977672
68tyrosine metabolic process (GO:0006570)3.19820428
69transmission of nerve impulse (GO:0019226)3.19204209
70positive regulation of synapse maturation (GO:0090129)3.18654813
71G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.17162878
72positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.16993016
73regulation of axon extension involved in axon guidance (GO:0048841)3.15382084
74neurotransmitter secretion (GO:0007269)3.15066482
75positive regulation of synaptic transmission, GABAergic (GO:0032230)3.13340695
76synapse assembly (GO:0007416)3.12101648
77pigment cell differentiation (GO:0050931)3.12069906
78exploration behavior (GO:0035640)3.11698583
79regulation of synapse assembly (GO:0051963)3.11383181
80response to amphetamine (GO:0001975)3.10753849
81regulation of synaptic plasticity (GO:0048167)3.07450055
82positive regulation of neuroblast proliferation (GO:0002052)3.06479232
83regulation of respiratory gaseous exchange (GO:0043576)3.04654611
84phenol-containing compound biosynthetic process (GO:0046189)3.04136125
85ganglion development (GO:0061548)3.04017257
86central nervous system projection neuron axonogenesis (GO:0021952)3.02815332
87synaptic vesicle maturation (GO:0016188)3.02442238
88learning (GO:0007612)3.02118200
89behavioral response to nicotine (GO:0035095)3.01235369
90dendrite development (GO:0016358)2.99928066
91serotonin metabolic process (GO:0042428)2.99590394
92dentate gyrus development (GO:0021542)2.99537249
93sodium ion export (GO:0071436)2.99155373
94regulation of axon guidance (GO:1902667)2.98634570
95positive regulation of dendritic spine development (GO:0060999)2.96376575
96regulation of neurotransmitter transport (GO:0051588)2.95709314
97behavioral response to cocaine (GO:0048148)2.93959036
98membrane depolarization (GO:0051899)2.93237337
99negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.92576820
100negative regulation of neurotransmitter transport (GO:0051589)2.92043677
101establishment of mitochondrion localization (GO:0051654)2.90819567
102dermatan sulfate biosynthetic process (GO:0030208)2.89427612
103regulation of dendritic spine morphogenesis (GO:0061001)2.89250483
104cardiac ventricle formation (GO:0003211)2.88954403
105cornea development in camera-type eye (GO:0061303)2.87589400
106cellular potassium ion homeostasis (GO:0030007)2.87050704
107central nervous system neuron axonogenesis (GO:0021955)2.86236326
108positive regulation of cellular response to oxidative stress (GO:1900409)2.85224237
109positive regulation of response to oxidative stress (GO:1902884)2.85224237
110nucleobase catabolic process (GO:0046113)2.84966013
111negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.84315920
112cAMP catabolic process (GO:0006198)2.83294658
113G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.82378006
114developmental pigmentation (GO:0048066)2.82122268
115positive regulation of synaptic transmission (GO:0050806)2.79658900
116locomotory exploration behavior (GO:0035641)2.79000650
117positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.78743163
118response to auditory stimulus (GO:0010996)2.78332980
119dendrite morphogenesis (GO:0048813)2.77968451
120regulation of synapse organization (GO:0050807)2.77554920
121gamma-aminobutyric acid transport (GO:0015812)2.77120940
122regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.77040467
123long-term memory (GO:0007616)2.76682427
124regulation of dendritic spine development (GO:0060998)2.75373289
125neuronal ion channel clustering (GO:0045161)2.75080457
126regulation of vesicle fusion (GO:0031338)2.74718442
127dendritic spine organization (GO:0097061)2.74534507
128opioid receptor signaling pathway (GO:0038003)2.74218895
129glycosphingolipid biosynthetic process (GO:0006688)2.73870584
130membrane assembly (GO:0071709)2.73706066
131behavioral fear response (GO:0001662)2.73187379
132behavioral defense response (GO:0002209)2.73187379
133regulation of synaptic transmission, GABAergic (GO:0032228)2.72791732
134response to dietary excess (GO:0002021)2.72728814
135neuroepithelial cell differentiation (GO:0060563)2.72285446
136negative regulation of axonogenesis (GO:0050771)2.61382640
137negative regulation of axon extension involved in axon guidance (GO:0048843)2.61139191
138dermatan sulfate metabolic process (GO:0030205)2.58916178
139axon extension (GO:0048675)2.57768128
140neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.57592021
141synaptic vesicle endocytosis (GO:0048488)2.56990811
142negative regulation of axon extension (GO:0030517)2.56697775
143regulation of neuron migration (GO:2001222)2.52296577
144olfactory bulb development (GO:0021772)2.49812974
145negative regulation of axon guidance (GO:1902668)2.45119013
146cerebellar Purkinje cell differentiation (GO:0021702)2.44590109
147cerebral cortex neuron differentiation (GO:0021895)2.42213482
148chondroitin sulfate catabolic process (GO:0030207)2.38575089
149neuron projection extension (GO:1990138)2.37913844

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.68468849
2GBX2_23144817_ChIP-Seq_PC3_Human4.54108041
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02580356
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02525615
5TAF15_26573619_Chip-Seq_HEK293_Human2.85949205
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.78255156
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69417036
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56867038
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54407192
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53486410
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.50829918
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.49707401
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.49707401
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47409293
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39666959
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.28456911
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28246330
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.25405463
19REST_21632747_ChIP-Seq_MESCs_Mouse2.24251911
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.16386659
21* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14453092
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.11672533
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10078496
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07999581
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.04232758
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02862417
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01929773
28* P300_19829295_ChIP-Seq_ESCs_Human1.99325619
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98525681
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96533408
31RNF2_27304074_Chip-Seq_NSC_Mouse1.94932235
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.92547190
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88143072
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83228230
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83211072
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82703717
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.82113212
38* RARB_27405468_Chip-Seq_BRAIN_Mouse1.76622302
39AR_21572438_ChIP-Seq_LNCaP_Human1.75540714
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.73267108
41SMAD4_21799915_ChIP-Seq_A2780_Human1.72327113
42FUS_26573619_Chip-Seq_HEK293_Human1.68108241
43* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67121810
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65485310
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.61919810
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.60666146
47* SMAD3_21741376_ChIP-Seq_EPCs_Human1.57916528
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53252496
49EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.52186748
50* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46832427
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.45062379
52GATA1_26923725_Chip-Seq_HPCs_Mouse1.42487184
53* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42376889
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.42059907
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41685166
56OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.40885471
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39733520
58VDR_22108803_ChIP-Seq_LS180_Human1.36531900
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.35913321
60* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35811766
61IGF1R_20145208_ChIP-Seq_DFB_Human1.35699934
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35535723
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35429255
64DROSHA_22980978_ChIP-Seq_HELA_Human1.35140759
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34964194
66AR_25329375_ChIP-Seq_VCAP_Human1.33508160
67ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30323713
68RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29817409
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28862496
70RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.27643426
71CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27278498
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.26946269
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.26548752
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26443805
75E2F1_18555785_Chip-Seq_ESCs_Mouse1.25588485
76P53_22387025_ChIP-Seq_ESCs_Mouse1.25454644
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25352400
78ER_23166858_ChIP-Seq_MCF-7_Human1.25224052
79EWS_26573619_Chip-Seq_HEK293_Human1.24852368
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24827387
81TCF4_23295773_ChIP-Seq_U87_Human1.19037212
82* RUNX2_22187159_ChIP-Seq_PCA_Human1.18823474
83SOX9_26525672_Chip-Seq_HEART_Mouse1.18284696
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17973134
85* TP53_18474530_ChIP-ChIP_U2OS_Human1.17894086
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17533993
87STAT3_23295773_ChIP-Seq_U87_Human1.16974740
88* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15673955
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.15626521
90ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15617972
91ISL1_27105846_Chip-Seq_CPCs_Mouse1.15560392
92* PRDM14_20953172_ChIP-Seq_ESCs_Human1.15396270
93SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13955386
94* SMAD3_21741376_ChIP-Seq_HESCs_Human1.13699005
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13394481
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13316498
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13316498
98* SMAD4_21741376_ChIP-Seq_HESCs_Human1.12558835
99* SMAD3_21741376_ChIP-Seq_ESCs_Human1.12288374
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.12260896
101SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.11779913
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10188461
103ERG_21242973_ChIP-ChIP_JURKAT_Human1.09411061
104AR_19668381_ChIP-Seq_PC3_Human1.09335297
105RING1B_27294783_Chip-Seq_ESCs_Mouse1.08901978
106EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08858281
107FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08606962
108JUN_21703547_ChIP-Seq_K562_Human1.08483353
109KDM2B_26808549_Chip-Seq_REH_Human1.07739717
110P300_18555785_Chip-Seq_ESCs_Mouse1.07672284
111* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07650238
112YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07435874
113ZNF274_21170338_ChIP-Seq_K562_Hela1.06642130
114MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06310469
115SOX2_21211035_ChIP-Seq_LN229_Gbm1.06165738
116RING1B_27294783_Chip-Seq_NPCs_Mouse1.06015420
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05852122
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05310511
119AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05286333
120STAT3_18555785_Chip-Seq_ESCs_Mouse1.04251115
121SOX2_18555785_Chip-Seq_ESCs_Mouse1.02930201
122AHR_22903824_ChIP-Seq_MCF-7_Human1.02745268
123SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01874838
124RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01475073
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01425561
126* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00761771
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99206994
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96513535
129CTCF_27219007_Chip-Seq_Bcells_Human0.96365652
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96329604
131ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96221788
132DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93492497
133* KDM2B_26808549_Chip-Seq_K562_Human0.92214899
134CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90888806
135* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88662042
136PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88546797
137SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88538502

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.66422881
2MP0004859_abnormal_synaptic_plasticity4.14263049
3MP0001968_abnormal_touch/_nociception3.48716446
4MP0003635_abnormal_synaptic_transmissio3.25919893
5MP0002736_abnormal_nociception_after3.17867595
6MP0004270_analgesia3.15929768
7MP0005257_abnormal_intraocular_pressure3.09026539
8MP0009745_abnormal_behavioral_response3.05910236
9MP0001188_hyperpigmentation3.04921127
10MP0000569_abnormal_digit_pigmentation2.91630068
11MP0002063_abnormal_learning/memory/cond2.80539189
12MP0002064_seizures2.59301648
13MP0002572_abnormal_emotion/affect_behav2.54180821
14MP0006292_abnormal_olfactory_placode2.53903338
15MP0002735_abnormal_chemical_nociception2.52795903
16MP0002734_abnormal_mechanical_nocicepti2.50295615
17MP0005646_abnormal_pituitary_gland2.42226898
18MP0009046_muscle_twitch2.41883692
19MP0005408_hypopigmentation2.30366530
20MP0001486_abnormal_startle_reflex2.29218731
21MP0002272_abnormal_nervous_system2.22999013
22MP0000778_abnormal_nervous_system2.21941711
23MP0005174_abnormal_tail_pigmentation2.12462067
24MP0001984_abnormal_olfaction2.10343066
25MP0002822_catalepsy2.09338028
26MP0005394_taste/olfaction_phenotype2.06352893
27MP0005499_abnormal_olfactory_system2.06352893
28MP0002095_abnormal_skin_pigmentation2.06143894
29MP0002067_abnormal_sensory_capabilities2.01850277
30MP0006276_abnormal_autonomic_nervous2.01381856
31MP0005423_abnormal_somatic_nervous2.00057546
32MP0004381_abnormal_hair_follicle1.94951483
33MP0008789_abnormal_olfactory_epithelium1.90664805
34MP0002184_abnormal_innervation1.87893789
35MP0001529_abnormal_vocalization1.85339142
36MP0003283_abnormal_digestive_organ1.84580815
37MP0005075_abnormal_melanosome_morpholog1.80667326
38MP0003787_abnormal_imprinting1.77909742
39MP0005409_darkened_coat_color1.75403876
40MP0001970_abnormal_pain_threshold1.73607304
41MP0002557_abnormal_social/conspecific_i1.73043579
42MP0003890_abnormal_embryonic-extraembry1.67377140
43MP0001905_abnormal_dopamine_level1.65349676
44MP0002733_abnormal_thermal_nociception1.65177463
45MP0002876_abnormal_thyroid_physiology1.59970720
46MP0000631_abnormal_neuroendocrine_gland1.59647579
47MP0002938_white_spotting1.59146416
48MP0001440_abnormal_grooming_behavior1.59007606
49MP0001501_abnormal_sleep_pattern1.58548297
50MP0005171_absent_coat_pigmentation1.58436377
51MP0003879_abnormal_hair_cell1.54818142
52MP0002751_abnormal_autonomic_nervous1.52996347
53MP0000371_diluted_coat_color1.50758153
54MP0005645_abnormal_hypothalamus_physiol1.50714231
55MP0002638_abnormal_pupillary_reflex1.49181406
56MP0008438_abnormal_cutaneous_collagen1.48037093
57MP0009379_abnormal_foot_pigmentation1.46717261
58MP0004924_abnormal_behavior1.45155695
59MP0005386_behavior/neurological_phenoty1.45155695
60MP0008569_lethality_at_weaning1.43336669
61MP0004811_abnormal_neuron_physiology1.43082496
62MP0002882_abnormal_neuron_morphology1.29738242
63MP0000566_synostosis1.29004834
64MP0001502_abnormal_circadian_rhythm1.26932032
65MP0000955_abnormal_spinal_cord1.26284018
66MP0000015_abnormal_ear_pigmentation1.26101733
67MP0002075_abnormal_coat/hair_pigmentati1.24949241
68MP0002653_abnormal_ependyma_morphology1.24357041
69MP0004742_abnormal_vestibular_system1.23310486
70MP0000534_abnormal_ureter_morphology1.20107266
71MP0004142_abnormal_muscle_tone1.19695691
72MP0009780_abnormal_chondrocyte_physiolo1.16204025
73MP0002066_abnormal_motor_capabilities/c1.14055850
74MP0005253_abnormal_eye_physiology1.13994373
75MP0001963_abnormal_hearing_physiology1.13091363
76MP0010386_abnormal_urinary_bladder1.12768716
77MP0003136_yellow_coat_color1.09611529
78MP0000026_abnormal_inner_ear1.09023581
79MP0002909_abnormal_adrenal_gland1.07038424
80MP0001485_abnormal_pinna_reflex1.05756335
81MP0002152_abnormal_brain_morphology1.03198595
82MP0003119_abnormal_digestive_system1.02076500
83MP0003938_abnormal_ear_development1.01768225
84MP0003385_abnormal_body_wall1.01107037
85MP0002752_abnormal_somatic_nervous1.00464582
86MP0004885_abnormal_endolymph1.00019914
87MP0004858_abnormal_nervous_system0.99796028
88MP0001324_abnormal_eye_pigmentation0.99733365
89MP0005197_abnormal_uvea_morphology0.95997691
90MP0000049_abnormal_middle_ear0.94612352
91MP0001186_pigmentation_phenotype0.93576425
92MP0002102_abnormal_ear_morphology0.91994958
93MP0001177_atelectasis0.88655482
94MP0001299_abnormal_eye_distance/0.85706036
95MP0006072_abnormal_retinal_apoptosis0.81794000
96MP0008260_abnormal_autophagy0.81101829
97MP0005623_abnormal_meninges_morphology0.81081729
98MP0004133_heterotaxia0.80908058
99MP0001664_abnormal_digestion0.79611359
100MP0003329_amyloid_beta_deposits0.79456616
101MP0002877_abnormal_melanocyte_morpholog0.79150136
102MP0005551_abnormal_eye_electrophysiolog0.78893449
103MP0002069_abnormal_eating/drinking_beha0.77886703
104MP0001986_abnormal_taste_sensitivity0.77246063
105MP0003633_abnormal_nervous_system0.77149267
106MP0002177_abnormal_outer_ear0.76713266
107MP0003631_nervous_system_phenotype0.74300021
108MP0009384_cardiac_valve_regurgitation0.73094945
109MP0010030_abnormal_orbit_morphology0.73082468
110MP0003634_abnormal_glial_cell0.73009786
111MP0000462_abnormal_digestive_system0.72289589
112MP0003122_maternal_imprinting0.71507066
113MP0003279_aneurysm0.71406965
114MP0003861_abnormal_nervous_system0.70646012
115MP0002229_neurodegeneration0.70328308
116MP0003937_abnormal_limbs/digits/tail_de0.69349026
117MP0002081_perinatal_lethality0.64592604
118MP0008872_abnormal_physiological_respon0.64040880
119MP0003755_abnormal_palate_morphology0.63989200
120MP0002090_abnormal_vision0.63630457
121MP0004085_abnormal_heartbeat0.63556813
122MP0002116_abnormal_craniofacial_bone0.62530434
123MP0003942_abnormal_urinary_system0.62487861
124MP0002249_abnormal_larynx_morphology0.61979687
125MP0008004_abnormal_stomach_pH0.61967427
126MP0000681_abnormal_thyroid_gland0.61008229
127MP0000751_myopathy0.59121260
128MP0008877_abnormal_DNA_methylation0.58201376
129MP0001943_abnormal_respiration0.58015952
130MP0000372_irregular_coat_pigmentation0.57963075
131MP0003183_abnormal_peptide_metabolism0.57430467
132MP0004145_abnormal_muscle_electrophysio0.56980499
133MP0003315_abnormal_perineum_morphology0.56713196
134MP0001346_abnormal_lacrimal_gland0.55131353
135MP0009250_abnormal_appendicular_skeleto0.54750724
136MP0008874_decreased_physiological_sensi0.53111835
137MP0002160_abnormal_reproductive_system0.52844423
138MP0010770_preweaning_lethality0.52765539
139MP0002082_postnatal_lethality0.52765539

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.52528102
2White forelock (HP:0002211)5.58428713
3Epileptic encephalopathy (HP:0200134)5.07867224
4Patchy hypopigmentation of hair (HP:0011365)5.03577244
5Febrile seizures (HP:0002373)4.89191092
6Hyperventilation (HP:0002883)4.82680017
7Myokymia (HP:0002411)4.59083265
8Atonic seizures (HP:0010819)4.52608215
9Focal seizures (HP:0007359)4.39981146
10Aplasia/Hypoplasia of the fovea (HP:0008060)4.32452817
11Hypoplasia of the fovea (HP:0007750)4.32452817
12Ocular albinism (HP:0001107)4.05695479
13Iris hypopigmentation (HP:0007730)3.86223312
14Broad-based gait (HP:0002136)3.83545097
15Aplasia/Hypoplasia of the macula (HP:0008059)3.81531997
16Abnormality of the fovea (HP:0000493)3.67686439
17Aplasia/Hypoplasia affecting the retina (HP:0008061)3.54860769
18Hypopigmentation of the fundus (HP:0007894)3.51975707
19Abnormal hair whorl (HP:0010721)3.33937121
20Abnormality of the lower motor neuron (HP:0002366)3.31019896
21Peripheral hypomyelination (HP:0007182)3.17887063
22Progressive cerebellar ataxia (HP:0002073)3.17168185
23Gait imbalance (HP:0002141)3.16052694
24Amblyopia (HP:0000646)3.15656426
25Dialeptic seizures (HP:0011146)3.14141136
26Medial flaring of the eyebrow (HP:0010747)3.11750216
27Absence seizures (HP:0002121)3.07606139
28Nephrogenic diabetes insipidus (HP:0009806)2.99914036
29Protruding tongue (HP:0010808)2.99865531
30Hypoplasia of the iris (HP:0007676)2.95168405
31Congenital primary aphakia (HP:0007707)2.93390344
32Gaze-evoked nystagmus (HP:0000640)2.89007049
33Sleep apnea (HP:0010535)2.86037945
34Generalized tonic-clonic seizures (HP:0002069)2.79697020
35Abnormal auditory evoked potentials (HP:0006958)2.79497124
36Hypothermia (HP:0002045)2.76284881
37Visual hallucinations (HP:0002367)2.74836561
38Degeneration of the lateral corticospinal tracts (HP:0002314)2.70292171
39Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.70292171
40Generalized hypopigmentation (HP:0007513)2.51075309
41Absent speech (HP:0001344)2.50415762
42Poor coordination (HP:0002370)2.43085191
43Limb dystonia (HP:0002451)2.40629265
44Akinesia (HP:0002304)2.38735269
45Genital tract atresia (HP:0001827)2.36391331
46Thickened helices (HP:0000391)2.36316870
47Excessive salivation (HP:0003781)2.34489260
48Drooling (HP:0002307)2.34489260
49Cerebral hypomyelination (HP:0006808)2.33629690
50Absent/shortened dynein arms (HP:0200106)2.33062678
51Dynein arm defect of respiratory motile cilia (HP:0012255)2.33062678
52Abnormality of the corticospinal tract (HP:0002492)2.32366674
53Fetal akinesia sequence (HP:0001989)2.32230265
54Vaginal atresia (HP:0000148)2.31730727
55Premature rupture of membranes (HP:0001788)2.28747096
56Abnormal eating behavior (HP:0100738)2.25736131
57Inability to walk (HP:0002540)2.21875879
58Optic nerve hypoplasia (HP:0000609)2.18805273
59Bowel diverticulosis (HP:0005222)2.17791925
60Incomplete penetrance (HP:0003829)2.15617705
61Cerebral aneurysm (HP:0004944)2.15353587
62Polyphagia (HP:0002591)2.15327546
63Epileptiform EEG discharges (HP:0011182)2.15259065
64Premature graying of hair (HP:0002216)2.13556330
65Shawl scrotum (HP:0000049)2.12400459
66Hammertoe (HP:0001765)2.12252816
67Blue irides (HP:0000635)2.11930281
68Stereotypic behavior (HP:0000733)2.11374600
69Impaired vibration sensation in the lower limbs (HP:0002166)2.10721024
70Slow-growing hair (HP:0002217)2.10631802
71Abnormality of hair growth rate (HP:0011363)2.10631802
72Obstructive sleep apnea (HP:0002870)2.08548345
73Hand muscle atrophy (HP:0009130)2.05477453
74Alacrima (HP:0000522)2.05024231
75Hypoventilation (HP:0002791)2.04019980
76Aplasia/Hypoplasia of the lens (HP:0008063)2.03993942
77Poor eye contact (HP:0000817)2.03442301
78Specific learning disability (HP:0001328)2.02955895
79Decreased lacrimation (HP:0000633)2.00323836
80Sensory axonal neuropathy (HP:0003390)2.00280277
81Intestinal atresia (HP:0011100)1.99364854
82Gastroesophageal reflux (HP:0002020)1.99145971
83Bladder diverticulum (HP:0000015)1.97997192
84Abnormal ciliary motility (HP:0012262)1.95783870
85Abnormal respiratory epithelium morphology (HP:0012253)1.95714136
86Abnormal respiratory motile cilium morphology (HP:0005938)1.95714136
87Esotropia (HP:0000565)1.93772185
88Acute necrotizing encephalopathy (HP:0006965)1.92549391
89Lissencephaly (HP:0001339)1.90594939
90Hyperthyroidism (HP:0000836)1.90062207
91Hyperacusis (HP:0010780)1.90014192
92Morphological abnormality of the middle ear (HP:0008609)1.88796155
93Anxiety (HP:0000739)1.85850525
94Absent eyebrow (HP:0002223)1.85721258
95Ankle clonus (HP:0011448)1.84287350
96Shallow orbits (HP:0000586)1.83893990
97Morphological abnormality of the inner ear (HP:0011390)1.83226318
98True hermaphroditism (HP:0010459)1.83163963
99Abnormality of the intervertebral disk (HP:0005108)1.83072917
100Annular pancreas (HP:0001734)1.82121716
101Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.81821921
102Abnormality of the ischium (HP:0003174)1.81726843
103Congenital sensorineural hearing impairment (HP:0008527)1.81609169
104Abnormality of the labia minora (HP:0012880)1.81189150
105Progressive inability to walk (HP:0002505)1.80663719
106Renovascular hypertension (HP:0100817)1.80297193
107Spastic gait (HP:0002064)1.80112205
108Short tibia (HP:0005736)1.79900645
109Abnormality of salivation (HP:0100755)1.78603174
110Heterochromia iridis (HP:0001100)1.78414562
111Failure to thrive in infancy (HP:0001531)1.77917319
112Exotropia (HP:0000577)1.77220489
113Optic disc pallor (HP:0000543)1.77062959
114Insomnia (HP:0100785)1.76906945
115Fair hair (HP:0002286)1.76579069
116Distal upper limb amyotrophy (HP:0007149)1.76269349
117Upper limb amyotrophy (HP:0009129)1.76269349
118Hypoplastic ischia (HP:0003175)1.75968367
119Renal duplication (HP:0000075)1.75635938
120Ulnar claw (HP:0001178)1.75088684
121Aplasia/Hypoplasia of the tibia (HP:0005772)1.74726154
122Cutaneous finger syndactyly (HP:0010554)1.74632117
123EEG with generalized epileptiform discharges (HP:0011198)1.74345761
124Elfin facies (HP:0004428)1.73787255
125Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73272262
126Progressive macrocephaly (HP:0004481)1.73249594
127Septo-optic dysplasia (HP:0100842)1.71902465
128Supranuclear gaze palsy (HP:0000605)1.70577190
129Cutaneous syndactyly (HP:0012725)1.70234587
130Urinary urgency (HP:0000012)1.70214710
131Deeply set eye (HP:0000490)1.68229611
132Retinal dysplasia (HP:0007973)1.68065769
133Poor suck (HP:0002033)1.68012120
134Truncal ataxia (HP:0002078)1.67868540
135Soft skin (HP:0000977)1.67812510
136Thyroid-stimulating hormone excess (HP:0002925)1.67350263
137Pancreatic fibrosis (HP:0100732)1.67256199
138Scanning speech (HP:0002168)1.66447748
139Action tremor (HP:0002345)1.66374081
140Dysphonia (HP:0001618)1.65186593
141Torticollis (HP:0000473)1.64961171
142Rib fusion (HP:0000902)1.64874873
143Narrow nasal bridge (HP:0000446)1.63979802
144Postaxial hand polydactyly (HP:0001162)1.63173081
145Large for gestational age (HP:0001520)1.63007563
146Dysdiadochokinesis (HP:0002075)1.62969859
147Generalized hypopigmentation of hair (HP:0011358)1.62740727
148Vertebral arch anomaly (HP:0008438)1.62375183
149Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.62358537
150Abnormal mitochondria in muscle tissue (HP:0008316)1.61978153
151Bradycardia (HP:0001662)1.61829766
152Abnormality of alanine metabolism (HP:0010916)1.61684076
153Hyperalaninemia (HP:0003348)1.61684076
154Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.61684076
155Spastic tetraplegia (HP:0002510)1.61150511
156Impaired vibratory sensation (HP:0002495)1.61056599
157Depression (HP:0000716)1.61041468
158Urinary bladder sphincter dysfunction (HP:0002839)1.60681282
159Nonprogressive disorder (HP:0003680)1.60171451
160Polymicrogyria (HP:0002126)1.59698731
161Hypoplasia of the brainstem (HP:0002365)1.59519518
162Aplasia/Hypoplasia of the brainstem (HP:0007362)1.59519518
163Infantile muscular hypotonia (HP:0008947)1.57594412
164Amyotrophic lateral sclerosis (HP:0007354)1.55954142
165Mild short stature (HP:0003502)1.54836731
166Freckling (HP:0001480)1.52683778
167Overriding aorta (HP:0002623)1.52098488
168Megalocornea (HP:0000485)1.48701869
169Hypoplastic nipples (HP:0002557)1.48335600
170Neurofibrillary tangles (HP:0002185)1.46237916
171Cortical dysplasia (HP:0002539)1.45756312
172Genu recurvatum (HP:0002816)1.44368283
173Megalencephaly (HP:0001355)1.44315080
174Neoplasm of the heart (HP:0100544)1.44064645
175Hemiparesis (HP:0001269)1.43224270

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK7.14906094
2EPHA43.90333452
3MAP2K73.19336074
4PRPF4B3.07153776
5CDK193.02083775
6DAPK22.71646832
7NTRK12.69874831
8NTRK32.60672690
9AKT32.49502263
10TNIK2.42321425
11TYRO32.26858687
12MARK12.26074693
13DDR22.24392331
14MAP3K42.21695562
15MAP3K122.20427624
16PLK22.11753000
17MAPK132.04540517
18CCNB11.93013732
19SGK21.82850076
20DAPK11.80193387
21SIK31.72624973
22BMPR21.69071718
23LMTK21.67330623
24OXSR11.63990550
25SGK2231.62323947
26SGK4941.62323947
27MINK11.57116576
28LATS21.53622048
29PAK31.51822577
30NTRK21.44358525
31MKNK21.41991077
32RIPK41.35055211
33FGFR21.32254876
34YES11.29179959
35PDGFRA1.27176907
36WEE11.23692641
37TRIM281.23607387
38ADRBK21.17058964
39ERBB31.15774317
40MAP2K41.10640277
41BRAF1.10214329
42PHKG21.08768563
43PHKG11.08768563
44TAOK11.08399061
45GRK51.02887634
46CDK51.02883447
47MKNK11.00836365
48SGK30.98863630
49MUSK0.97924090
50ERBB20.96164628
51MAP3K110.95451446
52MAP3K90.95297119
53PRKCG0.94832553
54CAMK2B0.93699433
55ICK0.90507947
56BCR0.89127038
57CAMK2A0.88925015
58KSR10.88192281
59MAP3K30.86121447
60CAMKK20.84559335
61WNK30.83887113
62CSNK1G30.83580167
63UHMK10.83555234
64DYRK20.80676238
65FES0.79692763
66STK160.78082247
67RIPK10.77574408
68CSNK1A1L0.77404521
69EIF2AK20.76816542
70CDK30.76616791
71TAOK20.75159022
72NME10.74695524
73GRK70.72064236
74PTK2B0.71774971
75EPHB20.71250792
76CSNK1G10.70580929
77CDK180.68282826
78FGR0.67376292
79ERBB40.66343172
80SIK20.65199985
81DYRK1A0.64493912
82LIMK10.62365318
83ARAF0.62315695
84ABL20.61306169
85PRKCE0.61268891
86BMPR1B0.61070759
87NEK60.58822442
88CDK140.58505290
89CDK150.57897098
90SRPK10.57111423
91ROCK10.56027456
92CAMK40.55183102
93SGK10.54736814
94PRKD20.54549518
95ADRBK10.52807110
96CAMK10.52533595
97PLK30.52124154
98CDK11A0.50708859
99MAP3K100.50581212
100PNCK0.49466305
101PAK60.49184033
102CAMKK10.47796839
103VRK10.47578028
104PKN20.46627654
105PDGFRB0.46490942
106PTK20.43261601
107PKN10.42589519
108TNK20.41570489
109BRSK10.41565186
110PAK20.40722929
111MAPK70.40128404
112CDK80.39383389
113TSSK60.39245851
114CSNK1E0.38899800
115CAMK2D0.38722911
116FRK0.38200383
117DAPK30.37276468
118RPS6KA20.36409809
119CSNK1D0.36160113
120PRKD10.36117433
121LATS10.34878084
122MAPK100.34243694
123STK110.34145665
124INSRR0.33443645
125MAP2K10.33252780
126PRKCH0.33212737
127FER0.32744916
128PRKACA0.31456240
129MAP3K60.30915467
130MARK20.30832409
131PINK10.30810431
132PRKD30.30629000
133CAMK2G0.29582510
134AURKA0.28289888
135EPHA30.28245432
136ROCK20.24247550
137PRKCZ0.22952404
138CSNK1G20.22153606
139PRKG10.21593034
140PRKCB0.19851162
141CSNK1A10.19669731
142PRKCA0.18765103

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.38302351
2Synaptic vesicle cycle_Homo sapiens_hsa047213.58676599
3Olfactory transduction_Homo sapiens_hsa047403.25234924
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.88660238
5Morphine addiction_Homo sapiens_hsa050322.79999692
6Circadian entrainment_Homo sapiens_hsa047132.66333726
7Amphetamine addiction_Homo sapiens_hsa050312.61439985
8Collecting duct acid secretion_Homo sapiens_hsa049662.58789915
9Glutamatergic synapse_Homo sapiens_hsa047242.51388268
10Long-term potentiation_Homo sapiens_hsa047202.45679177
11GABAergic synapse_Homo sapiens_hsa047272.35672131
12Taste transduction_Homo sapiens_hsa047422.33817906
13Dopaminergic synapse_Homo sapiens_hsa047282.27179777
14Serotonergic synapse_Homo sapiens_hsa047262.23495414
15Phototransduction_Homo sapiens_hsa047441.88502770
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.84944413
17Salivary secretion_Homo sapiens_hsa049701.81104854
18Insulin secretion_Homo sapiens_hsa049111.75743944
19Cholinergic synapse_Homo sapiens_hsa047251.75482863
20Renin secretion_Homo sapiens_hsa049241.68164953
21Long-term depression_Homo sapiens_hsa047301.67159932
22Axon guidance_Homo sapiens_hsa043601.67079016
23Calcium signaling pathway_Homo sapiens_hsa040201.65218863
24Vibrio cholerae infection_Homo sapiens_hsa051101.55851332
25Cocaine addiction_Homo sapiens_hsa050301.52793133
26Oxidative phosphorylation_Homo sapiens_hsa001901.52019313
27Gastric acid secretion_Homo sapiens_hsa049711.43824352
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40804119
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40567778
30Oxytocin signaling pathway_Homo sapiens_hsa049211.40227665
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.36755063
32Hippo signaling pathway_Homo sapiens_hsa043901.29329682
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29093089
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28730433
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25462481
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25434443
37ECM-receptor interaction_Homo sapiens_hsa045121.20371514
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19119831
39cAMP signaling pathway_Homo sapiens_hsa040241.18297085
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.15026762
41Gap junction_Homo sapiens_hsa045401.14932136
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13121561
43Melanogenesis_Homo sapiens_hsa049161.11775980
44ErbB signaling pathway_Homo sapiens_hsa040121.09382297
45GnRH signaling pathway_Homo sapiens_hsa049121.05828620
46Alzheimers disease_Homo sapiens_hsa050101.05762004
47Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.05269966
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04643777
49Dorso-ventral axis formation_Homo sapiens_hsa043200.99839939
50Rheumatoid arthritis_Homo sapiens_hsa053230.96912039
51Parkinsons disease_Homo sapiens_hsa050120.95723567
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95270994
53Protein digestion and absorption_Homo sapiens_hsa049740.92855071
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92191915
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88458507
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87515586
57Cardiac muscle contraction_Homo sapiens_hsa042600.82720051
58Huntingtons disease_Homo sapiens_hsa050160.81505453
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77846741
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77015042
61Wnt signaling pathway_Homo sapiens_hsa043100.76643104
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75916364
63Lysine degradation_Homo sapiens_hsa003100.75622826
64Circadian rhythm_Homo sapiens_hsa047100.75378990
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74621900
66Oocyte meiosis_Homo sapiens_hsa041140.74195526
67Focal adhesion_Homo sapiens_hsa045100.73992708
68Alcoholism_Homo sapiens_hsa050340.73775210
69Ras signaling pathway_Homo sapiens_hsa040140.72629960
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71735312
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71717866
72Glioma_Homo sapiens_hsa052140.70502654
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.70322536
74Adherens junction_Homo sapiens_hsa045200.66801107
75Tight junction_Homo sapiens_hsa045300.66483570
76Notch signaling pathway_Homo sapiens_hsa043300.65556750
77MAPK signaling pathway_Homo sapiens_hsa040100.64663626
78Phagosome_Homo sapiens_hsa041450.64423823
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64138301
80MicroRNAs in cancer_Homo sapiens_hsa052060.63918219
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61257029
82Estrogen signaling pathway_Homo sapiens_hsa049150.57344528
83Tyrosine metabolism_Homo sapiens_hsa003500.55407121
84Regulation of autophagy_Homo sapiens_hsa041400.54139802
85Bile secretion_Homo sapiens_hsa049760.49381755
86Hedgehog signaling pathway_Homo sapiens_hsa043400.48788387
87Melanoma_Homo sapiens_hsa052180.48733927
88Steroid biosynthesis_Homo sapiens_hsa001000.48704324
89Rap1 signaling pathway_Homo sapiens_hsa040150.46322043
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45815055
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45364321
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45117524
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43155217
94TGF-beta signaling pathway_Homo sapiens_hsa043500.42923897
95Endometrial cancer_Homo sapiens_hsa052130.42857817
96Type II diabetes mellitus_Homo sapiens_hsa049300.42465588
97Butanoate metabolism_Homo sapiens_hsa006500.41210168
98AMPK signaling pathway_Homo sapiens_hsa041520.40962750
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40592678
100Choline metabolism in cancer_Homo sapiens_hsa052310.40542890
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40309902
102African trypanosomiasis_Homo sapiens_hsa051430.40035088
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39907514
104Amoebiasis_Homo sapiens_hsa051460.39079332
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38489801
106Pancreatic secretion_Homo sapiens_hsa049720.37656517
107Autoimmune thyroid disease_Homo sapiens_hsa053200.32829584
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.31158655
109Basal transcription factors_Homo sapiens_hsa030220.29816143
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29584540
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.29491957
112Ether lipid metabolism_Homo sapiens_hsa005650.29017662
113Chemokine signaling pathway_Homo sapiens_hsa040620.28103562
114Prion diseases_Homo sapiens_hsa050200.27906409
115Colorectal cancer_Homo sapiens_hsa052100.27765031
116Ovarian steroidogenesis_Homo sapiens_hsa049130.27704696
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27209217
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.26644274
119Dilated cardiomyopathy_Homo sapiens_hsa054140.26489180
120Basal cell carcinoma_Homo sapiens_hsa052170.24912751
121Type I diabetes mellitus_Homo sapiens_hsa049400.23923672
122Inositol phosphate metabolism_Homo sapiens_hsa005620.23900180
123Fanconi anemia pathway_Homo sapiens_hsa034600.23023256
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.18595649
125Purine metabolism_Homo sapiens_hsa002300.17551097
126Thyroid hormone synthesis_Homo sapiens_hsa049180.16400146
127Prolactin signaling pathway_Homo sapiens_hsa049170.15947189
128Glucagon signaling pathway_Homo sapiens_hsa049220.13059252
129Thyroid cancer_Homo sapiens_hsa052160.11904922

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