LZTS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)4.75149903
2plasma membrane repair (GO:0001778)4.17725429
3polarized epithelial cell differentiation (GO:0030859)4.05554675
4semaphorin-plexin signaling pathway (GO:0071526)3.85358568
5epithelial cell-cell adhesion (GO:0090136)3.72435982
6cardiac myofibril assembly (GO:0055003)3.67731687
7hemidesmosome assembly (GO:0031581)3.63852972
8convergent extension (GO:0060026)3.55330868
9cytoskeletal anchoring at plasma membrane (GO:0007016)3.51488789
10sarcomere organization (GO:0045214)3.48641335
11endothelial cell chemotaxis (GO:0035767)3.48542564
12barbed-end actin filament capping (GO:0051016)3.43631244
13collagen fibril organization (GO:0030199)3.41945815
14planar cell polarity pathway involved in neural tube closure (GO:0090179)3.41250394
15regulation of early endosome to late endosome transport (GO:2000641)3.36559092
16basement membrane organization (GO:0071711)3.34405601
17paraxial mesoderm development (GO:0048339)3.33358418
18branching involved in salivary gland morphogenesis (GO:0060445)3.29893182
19regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.23757099
20establishment of apical/basal cell polarity (GO:0035089)3.22186756
21regulation of cardioblast differentiation (GO:0051890)3.20788945
22endodermal cell differentiation (GO:0035987)3.20474539
23cell-substrate junction assembly (GO:0007044)3.18771087
24stress fiber assembly (GO:0043149)3.18592963
25protein localization to endosome (GO:0036010)3.17387150
26regulation of hippo signaling (GO:0035330)3.15687614
27bone trabecula formation (GO:0060346)3.15570072
28hippo signaling (GO:0035329)3.15559695
29endocardial cushion development (GO:0003197)3.14318795
30skin morphogenesis (GO:0043589)3.13853419
31renal filtration (GO:0097205)3.12500260
32negative regulation of catenin import into nucleus (GO:0035414)3.09939027
33adherens junction assembly (GO:0034333)3.06747594
34retina vasculature morphogenesis in camera-type eye (GO:0061299)3.06337751
35regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.06105618
36negative regulation of fatty acid transport (GO:2000192)3.05849533
37negative regulation of cell size (GO:0045792)3.02834152
38peptidyl-proline hydroxylation (GO:0019511)2.98991230
39cell-cell junction maintenance (GO:0045217)2.98479326
40cochlea morphogenesis (GO:0090103)2.95915631
41chondrocyte proliferation (GO:0035988)2.95589682
42regulation of glucose import in response to insulin stimulus (GO:2001273)2.92120008
43glomerular basement membrane development (GO:0032836)2.91855914
44myofibril assembly (GO:0030239)2.89108708
45outer ear morphogenesis (GO:0042473)2.88624388
46glomerular filtration (GO:0003094)2.85732977
47protein hydroxylation (GO:0018126)2.85316118
48actomyosin structure organization (GO:0031032)2.84697041
49regulation of mammary gland epithelial cell proliferation (GO:0033599)2.83212849
50myelin maintenance (GO:0043217)2.79735961
51regulation of extracellular matrix disassembly (GO:0010715)2.78055303
52heart trabecula formation (GO:0060347)2.76781377
53apoptotic cell clearance (GO:0043277)2.75656199
54vascular endothelial growth factor signaling pathway (GO:0038084)2.75542522
55regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.75157473
56desmosome organization (GO:0002934)2.74647538
57cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.73246807
58vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.73162834
59collagen metabolic process (GO:0032963)2.72522554
60negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.72095935
61pattern specification involved in kidney development (GO:0061004)2.71885202
62dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.71601163
63regulation of tight junction assembly (GO:2000810)2.71467916
64insulin-like growth factor receptor signaling pathway (GO:0048009)2.70374117
65trabecula formation (GO:0060343)2.69122934
66negative regulation of potassium ion transmembrane transport (GO:1901380)2.68715481
67positive regulation of blood vessel endothelial cell migration (GO:0043536)2.67667156
68axon extension involved in axon guidance (GO:0048846)2.67245286
69neuron projection extension involved in neuron projection guidance (GO:1902284)2.67245286
70activation of Rac GTPase activity (GO:0032863)2.66806465
71maternal placenta development (GO:0001893)2.66274413
72creatine metabolic process (GO:0006600)2.65959631
73negative regulation of erythrocyte differentiation (GO:0045647)2.65157183
74bundle of His cell to Purkinje myocyte communication (GO:0086069)2.65075069
75proline biosynthetic process (GO:0006561)2.64649392
76collagen catabolic process (GO:0030574)2.63800490
77lung-associated mesenchyme development (GO:0060484)2.63237512
78regulation of p38MAPK cascade (GO:1900744)2.62140013
79multicellular organismal macromolecule metabolic process (GO:0044259)2.60137238
80cardiac muscle cell proliferation (GO:0060038)2.57809827
81negative regulation of chondrocyte differentiation (GO:0032331)2.56435338
82mannose metabolic process (GO:0006013)2.55761307
83protein targeting to plasma membrane (GO:0072661)2.55759211
84focal adhesion assembly (GO:0048041)2.54811502
85cell-substrate adherens junction assembly (GO:0007045)2.54811502
86negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.54613474
87peripheral nervous system axon ensheathment (GO:0032292)2.54486435
88myelination in peripheral nervous system (GO:0022011)2.54486435
89positive regulation of receptor recycling (GO:0001921)2.54037811
90extracellular matrix disassembly (GO:0022617)2.53856836
91retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.53546206
92non-canonical Wnt signaling pathway (GO:0035567)2.51833559
93adhesion of symbiont to host (GO:0044406)2.51768537
94actin-myosin filament sliding (GO:0033275)2.51757059
95muscle filament sliding (GO:0030049)2.51757059
96apoptotic process involved in morphogenesis (GO:0060561)2.51731577
97cell volume homeostasis (GO:0006884)2.50883076
98establishment or maintenance of monopolar cell polarity (GO:0061339)2.50808545
99establishment of monopolar cell polarity (GO:0061162)2.50808545
100Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.50741237
101cellular response to vitamin (GO:0071295)2.50599572
102endothelial cell morphogenesis (GO:0001886)2.49800755
103cardiac muscle cell development (GO:0055013)2.49633229
104cell migration involved in sprouting angiogenesis (GO:0002042)2.49379839
105multicellular organismal catabolic process (GO:0044243)2.49252467
106Golgi transport vesicle coating (GO:0048200)2.49063449
107COPI coating of Golgi vesicle (GO:0048205)2.49063449
108establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.48278494
109multicellular organismal metabolic process (GO:0044236)2.47781058
110anatomical structure regression (GO:0060033)2.47087694
111extracellular matrix assembly (GO:0085029)2.45491414
112cell migration involved in heart development (GO:0060973)2.44798532
113regulation of establishment of planar polarity (GO:0090175)2.44028326
114camera-type eye morphogenesis (GO:0048593)2.43962167
115notochord development (GO:0030903)2.41540068
116neural tube development (GO:0021915)2.41394801
117maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.41054189
118negative regulation of cartilage development (GO:0061037)2.40966694
119protein retention in ER lumen (GO:0006621)2.40414752
120tooth mineralization (GO:0034505)2.38458632
121mesenchyme development (GO:0060485)2.38085797
122regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.38045641
123kidney mesenchyme development (GO:0072074)2.38022093
124craniofacial suture morphogenesis (GO:0097094)2.37759147
125embryo implantation (GO:0007566)2.37335738
126positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.36891765
127cardiac cell development (GO:0055006)2.36806418
128outflow tract septum morphogenesis (GO:0003148)2.36510010
129atrioventricular valve morphogenesis (GO:0003181)2.36424085
130cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.36034295
131substrate adhesion-dependent cell spreading (GO:0034446)2.35395966
132cortical actin cytoskeleton organization (GO:0030866)2.35183152
133positive regulation of glycogen biosynthetic process (GO:0045725)2.34961933
134G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.34915937
135eye morphogenesis (GO:0048592)2.33238619
136embryonic eye morphogenesis (GO:0048048)2.30725184
137UV protection (GO:0009650)2.30073603
138positive regulation of odontogenesis (GO:0042482)2.29279353
139blood vessel endothelial cell migration (GO:0043534)2.28940041
140extracellular fibril organization (GO:0043206)2.28864851
141adhesion of symbiont to host cell (GO:0044650)2.28080529
142virion attachment to host cell (GO:0019062)2.28080529
143negative regulation of focal adhesion assembly (GO:0051895)2.26711941
144negative regulation of cell junction assembly (GO:1901889)2.26711941
145negative regulation of adherens junction organization (GO:1903392)2.26711941

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.86305014
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.57541642
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.54205707
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.08927174
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.05242523
6CLOCK_20551151_ChIP-Seq_293T_Human2.80374962
7ZNF263_19887448_ChIP-Seq_K562_Human2.38584220
8* ELK3_25401928_ChIP-Seq_HUVEC_Human2.26676001
9* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.24991651
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.23872314
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20483348
12* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.14670758
13* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.12662809
14* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.10771527
15* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.09152342
16* RACK7_27058665_Chip-Seq_MCF-7_Human2.07469624
17* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01624093
18KDM2B_26808549_Chip-Seq_SUP-B15_Human1.95274823
19LXR_22292898_ChIP-Seq_THP-1_Human1.90802483
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.84805856
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83628599
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.77655190
23* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74072896
24HIF1A_21447827_ChIP-Seq_MCF-7_Human1.73900541
25* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.73408353
26KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.73283650
27* KDM2B_26808549_Chip-Seq_DND41_Human1.72961591
28* ATF3_27146783_Chip-Seq_COLON_Human1.71968887
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.70669388
30TBX20_22328084_ChIP-Seq_HEART_Mouse1.69538798
31TBX20_22080862_ChIP-Seq_HEART_Mouse1.69538798
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.67089946
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66806043
34KDM2B_26808549_Chip-Seq_K562_Human1.65786681
35MYC_22102868_ChIP-Seq_BL_Human1.64791674
36SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.62441703
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59095265
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55765543
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.54317873
40* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.54227958
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54143502
42* TET1_21451524_ChIP-Seq_MESCs_Mouse1.53501037
43TP53_22127205_ChIP-Seq_IMR90_Human1.53244777
44SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.52388897
45CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.51199568
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51006487
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.50987868
48* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48542859
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.47087121
50* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.46088588
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.42465926
52* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38730371
53* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37512235
54TP53_20018659_ChIP-ChIP_R1E_Mouse1.37122425
55CREB1_26743006_Chip-Seq_LNCaP_Human1.34942999
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.31723189
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30858878
58TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28323134
59* RUNX1_27514584_Chip-Seq_MCF-7_Human1.27497158
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26775348
61SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26353926
62* KDM2B_26808549_Chip-Seq_JURKAT_Human1.25650853
63FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.25430426
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23253100
65TP53_23651856_ChIP-Seq_MEFs_Mouse1.22335208
66* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22306425
67* UBF1/2_26484160_Chip-Seq_HMECs_Human1.21349862
68NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21226421
69SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20060040
70MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.19920443
71ISL1_27105846_Chip-Seq_CPCs_Mouse1.19477631
72SMC1_22415368_ChIP-Seq_MEFs_Mouse1.19369722
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18943836
74* TET1_21490601_ChIP-Seq_MESCs_Mouse1.18277104
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17134908
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17118927
77* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15852830
78* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15132180
79* P68_20966046_ChIP-Seq_HELA_Human1.14813607
80FOXO3_23340844_ChIP-Seq_DLD1_Human1.14445083
81* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.14102028
82* TP63_22573176_ChIP-Seq_HFKS_Human1.12515307
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11904672
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.11801831
85* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11160050
86* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09940270
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09115611
88ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08440652
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07800028
90RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06838537
91* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04925754
92VDR_21846776_ChIP-Seq_THP-1_Human1.04296240
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03415090
94* SA1_27219007_Chip-Seq_ERYTHROID_Human1.03103103
95* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.02727351
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01886543
97SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01862079
98RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01148465
99EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01148465
100TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01106026
101TCF7_22412390_ChIP-Seq_EML_Mouse1.01033195
102CTCF_27219007_Chip-Seq_Bcells_Human1.00481310
103ELF1_20517297_ChIP-Seq_JURKAT_Human0.99487528
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99112546
105* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97708385
106EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97324949
107STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.97261844
108ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96958210
109* NCOR1_26117541_ChIP-Seq_K562_Human0.96915758
110* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96321562
111SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95672837
112KLF5_25053715_ChIP-Seq_YYC3_Human0.95397339
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95248286
114* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94819627
115ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94751959
116* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94531583
117SMC4_20622854_ChIP-Seq_HELA_Human0.94182724
118* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94163830
119EGR1_19374776_ChIP-ChIP_THP-1_Human0.93742143
120* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93535543
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93280910
122NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93123853

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.94743156
2MP0003705_abnormal_hypodermis_morpholog3.64289947
3MP0005275_abnormal_skin_tensile3.16836264
4MP0004272_abnormal_basement_membrane2.94079824
5MP0005623_abnormal_meninges_morphology2.88509882
6MP0000751_myopathy2.64948718
7MP0004858_abnormal_nervous_system2.60383503
8MP0010030_abnormal_orbit_morphology2.47017953
9MP0003283_abnormal_digestive_organ2.43049783
10MP0004084_abnormal_cardiac_muscle2.32530440
11MP0002837_dystrophic_cardiac_calcinosis2.31527214
12MP0005503_abnormal_tendon_morphology2.23306778
13MP0005058_abnormal_lysosome_morphology2.07401049
14MP0000537_abnormal_urethra_morphology2.00371506
15MP0003279_aneurysm1.97910667
16MP0001958_emphysema1.96666188
17MP0003566_abnormal_cell_adhesion1.85678852
18MP0000013_abnormal_adipose_tissue1.84937252
19MP0000750_abnormal_muscle_regeneration1.84485449
20MP0000733_abnormal_muscle_development1.79582883
21MP0005409_darkened_coat_color1.79429394
22MP0004185_abnormal_adipocyte_glucose1.75965235
23MP0000566_synostosis1.71159891
24MP0000003_abnormal_adipose_tissue1.70567141
25MP0006054_spinal_hemorrhage1.69535932
26MP0005330_cardiomyopathy1.67885066
27MP0004087_abnormal_muscle_fiber1.67841219
28MP0002234_abnormal_pharynx_morphology1.65622181
29MP0004233_abnormal_muscle_weight1.64293708
30MP0003385_abnormal_body_wall1.59751743
31MP0005375_adipose_tissue_phenotype1.59288543
32MP0005666_abnormal_adipose_tissue1.57265080
33MP0000749_muscle_degeneration1.56512525
34MP0004036_abnormal_muscle_relaxation1.53848988
35MP0002089_abnormal_postnatal_growth/wei1.53501294
36MP0009384_cardiac_valve_regurgitation1.48738776
37MP0002254_reproductive_system_inflammat1.46930694
38MP0006138_congestive_heart_failure1.46712156
39MP0001849_ear_inflammation1.43668113
40MP0000747_muscle_weakness1.42956286
41MP0005670_abnormal_white_adipose1.40769034
42MP0005508_abnormal_skeleton_morphology1.39658882
43MP0000534_abnormal_ureter_morphology1.38290406
44MP0010630_abnormal_cardiac_muscle1.36895856
45MP0002060_abnormal_skin_morphology1.35771755
46MP0002877_abnormal_melanocyte_morpholog1.35141700
47MP0000462_abnormal_digestive_system1.34825405
48MP0000759_abnormal_skeletal_muscle1.32614185
49MP0003453_abnormal_keratinocyte_physiol1.31529307
50MP0010234_abnormal_vibrissa_follicle1.27732026
51MP0005451_abnormal_body_composition1.27149506
52MP0002108_abnormal_muscle_morphology1.26890848
53MP0000428_abnormal_craniofacial_morphol1.25943585
54MP0004130_abnormal_muscle_cell1.24357715
55MP0003950_abnormal_plasma_membrane1.23966713
56MP0002269_muscular_atrophy1.23883685
57MP0000762_abnormal_tongue_morphology1.23082068
58MP0003942_abnormal_urinary_system1.22760445
59MP0010368_abnormal_lymphatic_system1.22501358
60MP0003115_abnormal_respiratory_system1.22315064
61MP0001348_abnormal_lacrimal_gland1.21884154
62MP0009250_abnormal_appendicular_skeleto1.19936156
63MP0002896_abnormal_bone_mineralization1.18333259
64MP0003091_abnormal_cell_migration1.17140975
65MP0004145_abnormal_muscle_electrophysio1.15775545
66MP0001299_abnormal_eye_distance/1.14721347
67MP0005023_abnormal_wound_healing1.08451022
68MP0008775_abnormal_heart_ventricle1.07947395
69MP0002106_abnormal_muscle_physiology1.07660969
70MP0004215_abnormal_myocardial_fiber1.07568607
71MP0002932_abnormal_joint_morphology1.07312335
72MP0003172_abnormal_lysosome_physiology1.07108957
73MP0002249_abnormal_larynx_morphology1.06979609
74MP0002972_abnormal_cardiac_muscle1.06891330
75MP0005620_abnormal_muscle_contractility1.06149089
76MP0005369_muscle_phenotype1.06067132
77MP0010352_gastrointestinal_tract_polyps1.06022687
78MP0005385_cardiovascular_system_phenoty1.04865926
79MP0001544_abnormal_cardiovascular_syste1.04865926
80MP0003119_abnormal_digestive_system1.04449563
81MP0002295_abnormal_pulmonary_circulatio1.01719456
82MP0009780_abnormal_chondrocyte_physiolo1.01123798
83MP0003935_abnormal_craniofacial_develop0.99283651
84MP0003137_abnormal_impulse_conducting0.99145818
85MP0009053_abnormal_anal_canal0.99126939
86MP0000049_abnormal_middle_ear0.98057853
87MP0005171_absent_coat_pigmentation0.96207552
88MP0003045_fibrosis0.96178039
89MP0005076_abnormal_cell_differentiation0.96069260
90MP0003941_abnormal_skin_development0.95035385
91MP0000467_abnormal_esophagus_morphology0.94757973
92MP0009840_abnormal_foam_cell0.93914284
93MP0000767_abnormal_smooth_muscle0.93855671
94MP0002653_abnormal_ependyma_morphology0.93606414
95MP0005595_abnormal_vascular_smooth0.93193953
96MP0003937_abnormal_limbs/digits/tail_de0.93169999
97MP0004197_abnormal_fetal_growth/weight/0.90891807
98MP0003755_abnormal_palate_morphology0.89673745
99MP0005501_abnormal_skin_physiology0.89628123
100MP0003329_amyloid_beta_deposits0.89422611
101MP0003567_abnormal_fetal_cardiomyocyte0.88369146
102MP0002111_abnormal_tail_morphology0.86615502
103MP0002282_abnormal_trachea_morphology0.86460019
104MP0002925_abnormal_cardiovascular_devel0.86399769
105MP0000266_abnormal_heart_morphology0.84801182
106MP0005257_abnormal_intraocular_pressure0.83799935
107MP0000579_abnormal_nail_morphology0.83455907
108MP0000678_abnormal_parathyroid_gland0.82895354
109MP0003634_abnormal_glial_cell0.82172971
110MP0009672_abnormal_birth_weight0.81791182
111MP0000163_abnormal_cartilage_morphology0.81353487
112MP0002796_impaired_skin_barrier0.81271095
113MP0009278_abnormal_bone_marrow0.81071818
114MP0008260_abnormal_autophagy0.80989421
115MP0002114_abnormal_axial_skeleton0.80968983
116MP0003123_paternal_imprinting0.80704785
117MP0002128_abnormal_blood_circulation0.80604631
118MP0002697_abnormal_eye_size0.80094375
119MP0005377_hearing/vestibular/ear_phenot0.79978921
120MP0003878_abnormal_ear_physiology0.79978921
121MP0002084_abnormal_developmental_patter0.79749141
122MP0001614_abnormal_blood_vessel0.79670073
123MP0000432_abnormal_head_morphology0.78824506
124MP0009379_abnormal_foot_pigmentation0.78367195
125MP0002116_abnormal_craniofacial_bone0.76709791
126MP0001542_abnormal_bone_strength0.76527663
127MP0004133_heterotaxia0.75322167
128MP0004510_myositis0.75274749
129MP0001243_abnormal_dermal_layer0.74507701
130MP0002113_abnormal_skeleton_development0.73320352
131MP0005390_skeleton_phenotype0.72603277
132MP0001661_extended_life_span0.72602973

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.53175718
2Protrusio acetabuli (HP:0003179)5.41163173
3Shallow orbits (HP:0000586)4.26674363
4Ankle contracture (HP:0006466)4.23388206
5Broad metatarsal (HP:0001783)3.89760164
6Muscle fiber splitting (HP:0003555)3.75208195
7Atrophic scars (HP:0001075)3.69388593
8Cerebral aneurysm (HP:0004944)3.62546240
9Increased connective tissue (HP:0009025)3.57971426
10Type 1 muscle fiber predominance (HP:0003803)3.48557931
11Fragile skin (HP:0001030)3.32763180
12Bladder diverticulum (HP:0000015)3.31690357
13Right ventricular cardiomyopathy (HP:0011663)3.13815410
14Increased variability in muscle fiber diameter (HP:0003557)3.12534084
15Hyporeflexia of lower limbs (HP:0002600)3.10184119
16Aortic dissection (HP:0002647)3.05498275
17Spinal rigidity (HP:0003306)3.03548879
18Mildly elevated creatine phosphokinase (HP:0008180)2.84953670
19Obstructive sleep apnea (HP:0002870)2.75275782
20Difficulty climbing stairs (HP:0003551)2.73352720
21Soft skin (HP:0000977)2.70831309
22Abnormality of skeletal muscle fiber size (HP:0012084)2.66051164
23Biconcave vertebral bodies (HP:0004586)2.61916640
24Difficulty running (HP:0009046)2.59625299
25Sudden death (HP:0001699)2.59234549
26Scapular winging (HP:0003691)2.59011266
27Distal lower limb amyotrophy (HP:0008944)2.56781062
28Ulnar bowing (HP:0003031)2.47162345
29Vascular tortuosity (HP:0004948)2.46923445
30Broad face (HP:0000283)2.45759702
31Abnormality of dentin (HP:0010299)2.42391250
32Ventricular tachycardia (HP:0004756)2.42305945
33Distal lower limb muscle weakness (HP:0009053)2.39151265
34Turricephaly (HP:0000262)2.36347062
35Buphthalmos (HP:0000557)2.36010447
36Arterial tortuosity (HP:0005116)2.34845077
37Mitral valve prolapse (HP:0001634)2.34657114
38Distal upper limb amyotrophy (HP:0007149)2.31745770
39Upper limb amyotrophy (HP:0009129)2.31745770
40Peritonitis (HP:0002586)2.29464398
41Hyperextensible skin (HP:0000974)2.28845032
42Disproportionate tall stature (HP:0001519)2.28368465
43Aortic aneurysm (HP:0004942)2.27835125
44Blue sclerae (HP:0000592)2.24970569
45Aneurysm (HP:0002617)2.24869356
46Genu recurvatum (HP:0002816)2.21001819
47Cervical subluxation (HP:0003308)2.19406484
48Insomnia (HP:0100785)2.18640584
49Follicular hyperkeratosis (HP:0007502)2.18637433
50Abnormality of the Achilles tendon (HP:0005109)2.17974359
51Renal duplication (HP:0000075)2.15620351
52Bowel diverticulosis (HP:0005222)2.15444662
53Round ear (HP:0100830)2.14358260
54Thin ribs (HP:0000883)2.13287252
55Wormian bones (HP:0002645)2.12910710
56Coronal craniosynostosis (HP:0004440)2.12572485
57Neonatal short-limb short stature (HP:0008921)2.11895873
58Deviation of the hallux (HP:0010051)2.11583387
59Dilatation of the ascending aorta (HP:0005111)2.10844818
60Hyperacusis (HP:0010780)2.10538154
61Abnormality of the calf musculature (HP:0001430)2.08026414
62Lipoatrophy (HP:0100578)2.06905240
63Bronchomalacia (HP:0002780)2.06552872
64Lymphangioma (HP:0100764)2.06247528
65Lower limb amyotrophy (HP:0007210)2.04395980
66Hallux valgus (HP:0001822)2.03197381
67Natal tooth (HP:0000695)2.01163150
68Thin bony cortex (HP:0002753)2.00775630
69Exercise-induced muscle cramps (HP:0003710)1.99128553
70Limb-girdle muscle weakness (HP:0003325)1.98768107
71Joint stiffness (HP:0001387)1.97757131
72Congenital glaucoma (HP:0001087)1.97536322
73Hypoventilation (HP:0002791)1.96391425
74Aplasia involving bones of the upper limbs (HP:0009823)1.94772003
75Abnormality of the acetabulum (HP:0003170)1.94743029
76Short nail (HP:0001799)1.94432478
77Bowing of the arm (HP:0006488)1.92771045
78Bowed forearm bones (HP:0003956)1.92771045
79Milia (HP:0001056)1.92013790
80Overriding aorta (HP:0002623)1.91892420
81Wrist flexion contracture (HP:0001239)1.91050252
82Stridor (HP:0010307)1.90951135
83Flat cornea (HP:0007720)1.90286804
84EMG: myopathic abnormalities (HP:0003458)1.89360357
85Elbow flexion contracture (HP:0002987)1.88929348
86Hypoplasia of the iris (HP:0007676)1.88322878
87Advanced eruption of teeth (HP:0006288)1.87328265
88Myoglobinuria (HP:0002913)1.86126436
89Flat acetabular roof (HP:0003180)1.85379703
90Pterygium (HP:0001059)1.85188407
91Arnold-Chiari malformation (HP:0002308)1.84414049
92Aortic regurgitation (HP:0001659)1.84191298
93Achilles tendon contracture (HP:0001771)1.83989786
94Long palpebral fissure (HP:0000637)1.83215777
95Exercise-induced myalgia (HP:0003738)1.83016290
96Abnormality of the 4th metacarpal (HP:0010012)1.81237581
97Mesangial abnormality (HP:0001966)1.80588013
98Premature skin wrinkling (HP:0100678)1.80364785
99Asymmetry of the thorax (HP:0001555)1.79921808
100Wide anterior fontanel (HP:0000260)1.78909174
101Centrally nucleated skeletal muscle fibers (HP:0003687)1.77323818
102Overgrowth (HP:0001548)1.76133765
103Nuclear cataract (HP:0100018)1.75848114
104Abnormality of the thoracic spine (HP:0100711)1.75839762
105Generalized amyotrophy (HP:0003700)1.74713562
106Mitral regurgitation (HP:0001653)1.74108633
107Myotonia (HP:0002486)1.73295801
108Atrial fibrillation (HP:0005110)1.73251221
109Ectopia lentis (HP:0001083)1.73074850
110Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72557413
111Short 4th metacarpal (HP:0010044)1.72557413
112Slender build (HP:0001533)1.71770747
113Myopathic facies (HP:0002058)1.71199256
114Renovascular hypertension (HP:0100817)1.70898742
115Abnormality of the calcaneus (HP:0008364)1.70337334
116Limb-girdle muscle atrophy (HP:0003797)1.70102342
117Rectal prolapse (HP:0002035)1.69992446
118Partial duplication of the phalanx of hand (HP:0009999)1.68546625
119Enlarged penis (HP:0000040)1.68318993
120J-shaped sella turcica (HP:0002680)1.67275566
121Bell-shaped thorax (HP:0001591)1.67088450
122Coxa vara (HP:0002812)1.66833857
123Elfin facies (HP:0004428)1.66494621
124Abnormal ossification of hand bones (HP:0005921)1.66003458
125Abnormality of the left ventricular outflow tract (HP:0011103)1.64486675
126Subaortic stenosis (HP:0001682)1.64486675
127Partial duplication of thumb phalanx (HP:0009944)1.64312499
128Asymmetric septal hypertrophy (HP:0001670)1.63254614
129Joint laxity (HP:0001388)1.62711984
130Vertebral compression fractures (HP:0002953)1.62023519
131Supraventricular arrhythmia (HP:0005115)1.61879891
132Bundle branch block (HP:0011710)1.59933130
133Hand muscle atrophy (HP:0009130)1.59661808
134Midface retrusion (HP:0011800)1.59633607
135Venous abnormality (HP:0002624)1.59021873
136Primary atrial arrhythmia (HP:0001692)1.58484723
137Aplasia of the phalanges of the hand (HP:0009802)1.57651056
138Aplasia involving bones of the extremities (HP:0009825)1.57651056

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.02904841
2TTN3.60828114
3PKN23.19678267
4DDR22.82390416
5PDGFRA2.63897774
6SMG12.51212693
7LATS22.37229541
8LATS12.34706751
9EEF2K2.27285253
10RIPK12.16755239
11EPHB22.12275270
12PRKD32.02734182
13SIK12.01364327
14ICK1.88897864
15NME21.87215388
16PRPF4B1.85056849
17EPHB11.74128375
18FGFR41.74123966
19ERN11.73500506
20PTK61.73275506
21MET1.65396462
22CDK121.60977894
23PAK21.59678534
24DMPK1.58887556
25PTK21.51214715
26PAK41.50908425
27ILK1.50668745
28LMTK21.50359738
29IRAK31.46325032
30BMX1.41743253
31FER1.39781149
32WNK41.38807002
33MAP3K101.35211114
34PAK31.35099462
35LRRK21.32987340
36STK391.28210517
37EPHA21.27419185
38TYRO31.26957472
39RPS6KA21.25731340
40BCKDK1.19396722
41MYLK1.16674548
42MTOR1.15930391
43ARAF1.15271859
44PHKG11.15036805
45PHKG21.15036805
46MAP3K61.14297410
47PRKD11.10006284
48LIMK11.02979322
49PDGFRB0.99195799
50FGFR20.99123846
51PAK60.97662258
52TIE10.97576026
53DAPK30.96403040
54KSR20.94318219
55FGFR10.93058972
56PRKD20.92449348
57MAP2K20.91069556
58ROCK20.90112004
59RPS6KC10.86243714
60RPS6KL10.86243714
61MAPK150.86015781
62NTRK10.84305595
63TAOK20.83417166
64MAPKAPK30.81198738
65RPS6KB20.79843684
66NEK10.78910080
67DYRK1B0.77600135
68CDC42BPA0.77578553
69RET0.77575637
70TRPM70.77464892
71ROCK10.74845989
72MARK20.72520136
73CAMK1D0.72175489
74STK38L0.71728963
75WNK10.71491507
76PDK30.71330460
77PDK40.71330460
78MAP3K130.71054252
79UHMK10.69916526
80MAP2K30.68446101
81TESK10.68377972
82FLT30.67520992
83BRAF0.66187939
84PAK10.65881627
85PIM20.65309956
86MAP2K10.64914592
87CDK70.64690879
88MAP3K70.62848076
89MAP3K110.62412722
90TAOK10.62021890
91RPS6KA60.60595566
92PRKG20.58300829
93PIK3CA0.57415507
94ABL20.57354881
95PTK2B0.56365744
96CAMK1G0.55240481
97MAP3K80.53810536
98MAP3K10.53617714
99MAP3K90.53352415
100TGFBR10.52304934
101STK30.51405384
102CAMK2D0.50808795
103MAPKAPK50.50129528
104HIPK20.49831236
105TGFBR20.49758100
106MAPK70.46936055
107MOS0.43958097
108ALK0.43480597
109TESK20.42097901
110GSK3A0.41771450
111CAMK2G0.41706443
112AKT20.41656544
113PDK20.39582228
114STK380.38593209
115NEK20.38450749
116CDK11A0.38428266
117MAPK120.37875601
118MAP3K30.37692452
119ERBB20.37017427
120CDK150.35509536
121PDPK10.34771234
122MUSK0.33722112
123PRKCH0.33630852
124KDR0.32931590
125MAP3K20.32272631
126RPS6KA10.31632254
127OBSCN0.31214985
128SRC0.30874322
129OXSR10.30819459
130MAPK100.29310223
131MST1R0.28094262
132MAPK40.27891576
133CDK190.27169026
134PRKAA20.26994647

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.17998098
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.67758806
3Focal adhesion_Homo sapiens_hsa045102.49095542
4Dilated cardiomyopathy_Homo sapiens_hsa054142.34077118
5Other glycan degradation_Homo sapiens_hsa005112.31807167
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.25967375
7Basal cell carcinoma_Homo sapiens_hsa052172.24415690
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.17278694
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.13503622
10Hippo signaling pathway_Homo sapiens_hsa043902.10494454
11Hedgehog signaling pathway_Homo sapiens_hsa043402.08501994
12Tight junction_Homo sapiens_hsa045302.04094462
13Protein digestion and absorption_Homo sapiens_hsa049741.98229466
14Bladder cancer_Homo sapiens_hsa052191.95415769
15Proteoglycans in cancer_Homo sapiens_hsa052051.91708275
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.90451581
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.81788796
18Adherens junction_Homo sapiens_hsa045201.62184101
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.59650448
20Small cell lung cancer_Homo sapiens_hsa052221.55256354
21Amoebiasis_Homo sapiens_hsa051461.54698626
22Prion diseases_Homo sapiens_hsa050201.45813976
23Notch signaling pathway_Homo sapiens_hsa043301.40892506
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.33085170
25Renal cell carcinoma_Homo sapiens_hsa052111.28607459
26Sulfur relay system_Homo sapiens_hsa041221.28401683
27Chronic myeloid leukemia_Homo sapiens_hsa052201.25767539
28AMPK signaling pathway_Homo sapiens_hsa041521.24165759
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.22208509
30Fatty acid metabolism_Homo sapiens_hsa012121.21716831
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19499101
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17467594
33Fatty acid biosynthesis_Homo sapiens_hsa000611.16628707
34PI3K-Akt signaling pathway_Homo sapiens_hsa041511.16346330
35Melanogenesis_Homo sapiens_hsa049161.16028074
36TGF-beta signaling pathway_Homo sapiens_hsa043501.15976249
37Axon guidance_Homo sapiens_hsa043601.15077609
38MicroRNAs in cancer_Homo sapiens_hsa052061.14422072
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.12338620
40Propanoate metabolism_Homo sapiens_hsa006401.09832744
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09033916
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08879112
43mTOR signaling pathway_Homo sapiens_hsa041501.04821578
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04466224
45Cardiac muscle contraction_Homo sapiens_hsa042601.03428591
46Galactose metabolism_Homo sapiens_hsa000521.02332609
47Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02098932
48Insulin resistance_Homo sapiens_hsa049311.02014631
49Adipocytokine signaling pathway_Homo sapiens_hsa049201.01974257
50Pentose phosphate pathway_Homo sapiens_hsa000301.01958202
51Carbon metabolism_Homo sapiens_hsa012001.00861113
52Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00004047
53Fructose and mannose metabolism_Homo sapiens_hsa000510.99211000
54Wnt signaling pathway_Homo sapiens_hsa043100.98917080
55Pathways in cancer_Homo sapiens_hsa052000.98836646
56Gap junction_Homo sapiens_hsa045400.97761731
57VEGF signaling pathway_Homo sapiens_hsa043700.97272621
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95401914
59Estrogen signaling pathway_Homo sapiens_hsa049150.94148530
60Insulin signaling pathway_Homo sapiens_hsa049100.93410968
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93167368
62Melanoma_Homo sapiens_hsa052180.92835624
63Thyroid cancer_Homo sapiens_hsa052160.92727918
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.91760709
65Fatty acid degradation_Homo sapiens_hsa000710.91507560
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.87119456
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86517358
68Rap1 signaling pathway_Homo sapiens_hsa040150.85730105
69Endometrial cancer_Homo sapiens_hsa052130.84005470
70Glioma_Homo sapiens_hsa052140.83667904
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82365156
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80631084
73PPAR signaling pathway_Homo sapiens_hsa033200.80192496
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79395674
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79255004
76Biosynthesis of amino acids_Homo sapiens_hsa012300.76955255
77Pyruvate metabolism_Homo sapiens_hsa006200.76917200
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75960231
79Endocytosis_Homo sapiens_hsa041440.75052034
80HIF-1 signaling pathway_Homo sapiens_hsa040660.74679329
81Viral myocarditis_Homo sapiens_hsa054160.74549888
82Lysine degradation_Homo sapiens_hsa003100.71979921
83Inositol phosphate metabolism_Homo sapiens_hsa005620.71657347
84Fatty acid elongation_Homo sapiens_hsa000620.70291233
85Choline metabolism in cancer_Homo sapiens_hsa052310.69061992
86Long-term potentiation_Homo sapiens_hsa047200.68381777
87Lysosome_Homo sapiens_hsa041420.67999074
88Prostate cancer_Homo sapiens_hsa052150.66786222
89Vitamin B6 metabolism_Homo sapiens_hsa007500.65960380
90Fat digestion and absorption_Homo sapiens_hsa049750.64739487
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.64700503
92Glucagon signaling pathway_Homo sapiens_hsa049220.62820612
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62435080
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61353207
95Pancreatic cancer_Homo sapiens_hsa052120.60649396
96Platelet activation_Homo sapiens_hsa046110.60235124
97Nitrogen metabolism_Homo sapiens_hsa009100.59229214
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59167910
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58536222
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58394804
101GnRH signaling pathway_Homo sapiens_hsa049120.57646762
102Gastric acid secretion_Homo sapiens_hsa049710.57530121
103Dorso-ventral axis formation_Homo sapiens_hsa043200.56208459
104Ovarian steroidogenesis_Homo sapiens_hsa049130.55889101
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54900100
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54130185
107Colorectal cancer_Homo sapiens_hsa052100.54048761
108MAPK signaling pathway_Homo sapiens_hsa040100.53993155
109Vibrio cholerae infection_Homo sapiens_hsa051100.53942337
110Thyroid hormone synthesis_Homo sapiens_hsa049180.53497953
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.53283700
112Non-small cell lung cancer_Homo sapiens_hsa052230.52824960
113Prolactin signaling pathway_Homo sapiens_hsa049170.52394768
114Ras signaling pathway_Homo sapiens_hsa040140.50272005
115Phenylalanine metabolism_Homo sapiens_hsa003600.49727253
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49551811
117ErbB signaling pathway_Homo sapiens_hsa040120.49307283
118Pancreatic secretion_Homo sapiens_hsa049720.49038279
119Arginine and proline metabolism_Homo sapiens_hsa003300.47647258
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47407317
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.47262479
122Acute myeloid leukemia_Homo sapiens_hsa052210.47094209
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46948403
124Oxytocin signaling pathway_Homo sapiens_hsa049210.46163778
125Arginine biosynthesis_Homo sapiens_hsa002200.45719927

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