M1AP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is likely to function in progression of meiosis. A similar protein in mouse plays a role in gametogenesis in both sexes. Alternate splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female receptivity (GO:0045924)5.20583011
2male meiosis (GO:0007140)4.99409125
3synapsis (GO:0007129)4.90912044
4female mating behavior (GO:0060180)4.88436955
5DNA methylation involved in gamete generation (GO:0043046)4.83267560
6male meiosis I (GO:0007141)4.82591013
7meiosis I (GO:0007127)4.67937273
8protein neddylation (GO:0045116)4.41409514
9regulation of activation of Janus kinase activity (GO:0010533)4.29487076
10chromosome organization involved in meiosis (GO:0070192)4.15203332
11regulation of T-helper 1 cell differentiation (GO:0045625)3.84547025
12natural killer cell mediated immunity (GO:0002228)3.78621325
13natural killer cell mediated cytotoxicity (GO:0042267)3.78621325
14daunorubicin metabolic process (GO:0044597)3.68600714
15polyketide metabolic process (GO:0030638)3.68600714
16doxorubicin metabolic process (GO:0044598)3.68600714
17pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.57786752
18ribosomal small subunit assembly (GO:0000028)3.47715739
19DNA double-strand break processing (GO:0000729)3.39682085
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.29452645
21neutrophil activation involved in immune response (GO:0002283)3.28452753
22piRNA metabolic process (GO:0034587)3.28404226
23rRNA methylation (GO:0031167)3.28322146
24B cell mediated immunity (GO:0019724)3.28027694
25proteasome assembly (GO:0043248)3.27685465
26deoxyribonucleotide catabolic process (GO:0009264)3.22730845
27positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.21149587
28response to interferon-beta (GO:0035456)3.20942487
29DNA replication-dependent nucleosome assembly (GO:0006335)3.19074681
30DNA replication-dependent nucleosome organization (GO:0034723)3.19074681
31T-helper 1 type immune response (GO:0042088)3.17433767
32positive regulation of T-helper cell differentiation (GO:0045624)3.16291433
33immunoglobulin mediated immune response (GO:0016064)3.16207740
34DNA synthesis involved in DNA repair (GO:0000731)3.15847708
35deoxyribose phosphate catabolic process (GO:0046386)3.13503720
36telomere maintenance via semi-conservative replication (GO:0032201)3.10785370
37DNA strand elongation involved in DNA replication (GO:0006271)3.07456355
38cellular response to interferon-beta (GO:0035458)3.05944966
39multicellular organism reproduction (GO:0032504)3.04045789
40deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.03219624
41positive regulation of interferon-alpha production (GO:0032727)3.02812154
42formation of translation preinitiation complex (GO:0001731)2.99469030
43regulation of histone H3-K9 methylation (GO:0051570)2.98476565
44nuclear pore complex assembly (GO:0051292)2.94220543
45autophagic vacuole fusion (GO:0000046)2.94047987
46DNA strand elongation (GO:0022616)2.92757703
47positive regulation of alpha-beta T cell proliferation (GO:0046641)2.92524391
48positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.91752006
49nuclear pore organization (GO:0006999)2.91329628
50purinergic nucleotide receptor signaling pathway (GO:0035590)2.90536898
51hyperosmotic salinity response (GO:0042538)2.88944604
52dopamine transport (GO:0015872)2.87123293
53negative regulation of thymocyte apoptotic process (GO:0070244)2.86393638
54thrombin receptor signaling pathway (GO:0070493)2.86044137
55* meiotic cell cycle process (GO:1903046)2.85703674
56L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.84502749
57pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.84229668
58DNA replication checkpoint (GO:0000076)2.84001353
59regulation of megakaryocyte differentiation (GO:0045652)2.83753267
60respiratory chain complex IV assembly (GO:0008535)2.82333597
61telomere maintenance via recombination (GO:0000722)2.81857330
62regulation of interferon-alpha production (GO:0032647)2.81522627
63DNA replication initiation (GO:0006270)2.81277044
64reciprocal meiotic recombination (GO:0007131)2.81044056
65reciprocal DNA recombination (GO:0035825)2.81044056
66DNA deamination (GO:0045006)2.78231923
67purine-containing compound salvage (GO:0043101)2.77812368
68fusion of sperm to egg plasma membrane (GO:0007342)2.77018532
69regulation of RIG-I signaling pathway (GO:0039535)2.76578970
70neutrophil activation (GO:0042119)2.75976815
71regulation of memory T cell differentiation (GO:0043380)2.75015088
72adenosine metabolic process (GO:0046085)2.74904196
73gene silencing by RNA (GO:0031047)2.73668671
74positive regulation of defense response to virus by host (GO:0002230)2.73212511
75response to peptidoglycan (GO:0032494)2.72112114
76mismatch repair (GO:0006298)2.71391882
77negative regulation of viral genome replication (GO:0045071)2.71107143
78pseudouridine synthesis (GO:0001522)2.70041645
79organelle membrane fusion (GO:0090174)2.69379108
80negative regulation by host of viral transcription (GO:0043922)2.68805077
81positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.68142555
82regulation of interferon-gamma biosynthetic process (GO:0045072)2.68128460
83regulation of T-helper cell differentiation (GO:0045622)2.67736113
84positive regulation of interleukin-12 production (GO:0032735)2.67636922
85positive regulation of type 2 immune response (GO:0002830)2.67464600
86protein localization to kinetochore (GO:0034501)2.67056233
87lipoxygenase pathway (GO:0019372)2.66243863
88deoxyribose phosphate metabolic process (GO:0019692)2.66171862
89granulocyte activation (GO:0036230)2.65899357
90pyrimidine nucleotide catabolic process (GO:0006244)2.65203054
91ubiquinone biosynthetic process (GO:0006744)2.63796545
92mitochondrial respiratory chain complex I assembly (GO:0032981)2.62450404
93NADH dehydrogenase complex assembly (GO:0010257)2.62450404
94mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.62450404
95DNA catabolic process, exonucleolytic (GO:0000738)2.62379199
96cytochrome complex assembly (GO:0017004)2.62119098
97positive regulation of protein homooligomerization (GO:0032464)2.62064716
98RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.61659173
99tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.61659173
100synaptonemal complex assembly (GO:0007130)2.60468960
101leukocyte mediated cytotoxicity (GO:0001909)2.60151750
102mitotic nuclear envelope disassembly (GO:0007077)2.59179172
103regulation of female gonad development (GO:2000194)2.57983659
104detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.57459345
105regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.57216490
106maturation of SSU-rRNA (GO:0030490)2.56203461
107positive regulation of mast cell activation (GO:0033005)2.56137137
108sperm motility (GO:0030317)2.55810663
109protein localization to chromosome, centromeric region (GO:0071459)2.55224324
110regulation of alpha-beta T cell proliferation (GO:0046640)2.54718296
111positive regulation of natural killer cell differentiation (GO:0032825)2.53870055
112NIK/NF-kappaB signaling (GO:0038061)2.53122906
113mitotic recombination (GO:0006312)2.52468485
114defense response to protozoan (GO:0042832)2.52222969
115regulation of defense response to virus by host (GO:0050691)2.52070406
116regulation of meiosis I (GO:0060631)2.51687422
117double-strand break repair via homologous recombination (GO:0000724)2.51428939
118pore complex assembly (GO:0046931)2.51191657
119negative regulation of interleukin-17 production (GO:0032700)2.51168094
120nucleoside salvage (GO:0043174)2.51081007
121regulation of T-helper 2 cell differentiation (GO:0045628)2.50962410
122positive regulation of uterine smooth muscle contraction (GO:0070474)2.50087825
123recombinational repair (GO:0000725)2.48132451
124positive regulation of protein oligomerization (GO:0032461)2.47904767
125antigen processing and presentation of endogenous antigen (GO:0019883)2.47203350
126ribosomal small subunit biogenesis (GO:0042274)2.46859581
127regulation of response to tumor cell (GO:0002834)2.46858163
128positive regulation of response to tumor cell (GO:0002836)2.46858163
129positive regulation of immune response to tumor cell (GO:0002839)2.46858163
130regulation of immune response to tumor cell (GO:0002837)2.46858163
131response to interferon-alpha (GO:0035455)2.46826167
132single strand break repair (GO:0000012)2.46008062
133regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.45910980
134relaxation of smooth muscle (GO:0044557)2.45430475
135transcription from mitochondrial promoter (GO:0006390)2.44036214
136antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.43600127
137lymphocyte mediated immunity (GO:0002449)2.42685291
138plasma membrane fusion (GO:0045026)2.42673430
139histone mRNA metabolic process (GO:0008334)2.42356783
140negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.40390853
141positive regulation of protein import into nucleus, translocation (GO:0033160)2.40212429
142replication fork processing (GO:0031297)2.39867173
143myeloid dendritic cell differentiation (GO:0043011)2.39673380
144cardiolipin metabolic process (GO:0032048)2.39513854
145methionine metabolic process (GO:0006555)2.38809151
146sperm-egg recognition (GO:0035036)2.38503984
147iron-sulfur cluster assembly (GO:0016226)2.37834521
148metallo-sulfur cluster assembly (GO:0031163)2.37834521
149positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.37692256
150positive regulation of megakaryocyte differentiation (GO:0045654)2.36742576
151synaptonemal complex organization (GO:0070193)2.36737487
152protein complex biogenesis (GO:0070271)2.36567103
153positive regulation of interferon-beta production (GO:0032728)2.36486757
154binding of sperm to zona pellucida (GO:0007339)2.36019723
155ribosome biogenesis (GO:0042254)2.35948191
156centriole replication (GO:0007099)2.35886616
157RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.35832705
158membrane disassembly (GO:0030397)2.35562578
159nuclear envelope disassembly (GO:0051081)2.35562578
160cell-cell recognition (GO:0009988)2.34922460
161cellular response to type I interferon (GO:0071357)2.34476457
162type I interferon signaling pathway (GO:0060337)2.34476457
163spermatid development (GO:0007286)2.33732634
164DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.33594379
165methionine biosynthetic process (GO:0009086)2.33483664
166positive regulation of isotype switching (GO:0045830)2.33397362
167antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.33060735
168negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.33035574
169amine catabolic process (GO:0009310)2.32230799
170cellular biogenic amine catabolic process (GO:0042402)2.32230799
171rRNA modification (GO:0000154)2.32006863
172polyamine biosynthetic process (GO:0006596)2.31655431
173deoxyribonucleotide metabolic process (GO:0009262)2.31524484
174intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.30103563
175signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.30103563
176regulation of double-strand break repair via homologous recombination (GO:0010569)2.29849424
177cellular biogenic amine biosynthetic process (GO:0042401)2.29579245
178response to type I interferon (GO:0034340)2.29516378
179cellular response to virus (GO:0098586)2.29282041
180myeloid dendritic cell activation (GO:0001773)2.29244845
181meiotic nuclear division (GO:0007126)2.28415644
182regulation of cellular amino acid metabolic process (GO:0006521)2.28268065
183negative regulation of appetite (GO:0032099)2.27419031
184negative regulation of response to food (GO:0032096)2.27419031
185positive regulation of mast cell activation involved in immune response (GO:0033008)2.26937796
186positive regulation of mast cell degranulation (GO:0043306)2.26937796

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.28323484
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.53641537
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.64197061
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.47428930
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.00748066
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99258901
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.92412590
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.88920731
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.84572476
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.62948330
11IGF1R_20145208_ChIP-Seq_DFB_Human2.56820053
12GATA1_22025678_ChIP-Seq_K562_Human2.44682398
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.32603003
14VDR_22108803_ChIP-Seq_LS180_Human2.30988260
15LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.26644681
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.08365740
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.07883145
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05549450
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04502348
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.04417915
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.01850251
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01689344
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00717404
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.00110487
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.99942421
26ZNF274_21170338_ChIP-Seq_K562_Hela1.97599419
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.89842166
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83250710
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.81805941
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80294014
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75735372
32VDR_23849224_ChIP-Seq_CD4+_Human1.75218035
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74039961
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.73388325
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73362782
36MYC_18940864_ChIP-ChIP_HL60_Human1.72989287
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.71013130
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.69436640
39SPI1_23547873_ChIP-Seq_NB4_Human1.69018849
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67803556
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.64750765
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.63435968
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63431575
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60223674
45SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.59924838
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59520104
47TP53_22573176_ChIP-Seq_HFKS_Human1.58851764
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58738802
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57087676
50KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.55768170
51XRN2_22483619_ChIP-Seq_HELA_Human1.51875899
52EWS_26573619_Chip-Seq_HEK293_Human1.50197648
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49837821
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49666853
55DCP1A_22483619_ChIP-Seq_HELA_Human1.48510357
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.47451274
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47206164
58KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.42792816
59KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.42792816
60KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.42792816
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42538768
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41847531
63NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38885401
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38877492
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35453354
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.31680281
67ELK1_19687146_ChIP-ChIP_HELA_Human1.31629316
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31029560
69FOXP3_21729870_ChIP-Seq_TREG_Human1.30612675
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29801553
71SCL_19346495_ChIP-Seq_HPC-7_Human1.29490702
72IRF1_19129219_ChIP-ChIP_H3396_Human1.28445291
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28347201
74HTT_18923047_ChIP-ChIP_STHdh_Human1.27889315
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.26039793
76FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25866081
77SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25864789
78MYB_26560356_Chip-Seq_TH2_Human1.25684789
79GATA3_26560356_Chip-Seq_TH2_Human1.25523117
80GATA3_21878914_ChIP-Seq_MCF-7_Human1.25126574
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24565158
82GABP_19822575_ChIP-Seq_HepG2_Human1.23917775
83HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.23124714
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22752097
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22197126
86SRF_21415370_ChIP-Seq_HL-1_Mouse1.21469692
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21092403
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.21092403
89NANOG_20526341_ChIP-Seq_ESCs_Human1.20809571
90TFEB_21752829_ChIP-Seq_HELA_Human1.20541295
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19623479
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18372218
93MYB_26560356_Chip-Seq_TH1_Human1.17162109
94RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17126720
95NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.17008870
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16983198
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16907918
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16850028
99POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16292829
100AR_20517297_ChIP-Seq_VCAP_Human1.15741906
101RUNX1_22412390_ChIP-Seq_EML_Mouse1.15417356
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13983922
103MYC_22102868_ChIP-Seq_BL_Human1.13779842
104VDR_21846776_ChIP-Seq_THP-1_Human1.13114319
105GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12252376
106STAT1_20625510_ChIP-Seq_HELA_Human1.11367513
107BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10969927
108FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10799732
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10326007
110FLI1_27457419_Chip-Seq_LIVER_Mouse1.09412517
111EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08874847
112TTF2_22483619_ChIP-Seq_HELA_Human1.08663275
113STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.07973726
114BCAT_22108803_ChIP-Seq_LS180_Human1.07684003
115CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07532539
116POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06726493
117ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06530201
118ER_23166858_ChIP-Seq_MCF-7_Human1.05086655
119HOXB7_26014856_ChIP-Seq_BT474_Human1.04957392
120MAF_26560356_Chip-Seq_TH1_Human1.04605356
121ERA_21632823_ChIP-Seq_H3396_Human1.04499948
122PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03792880
123FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03787521
124TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03739499
125POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03626224
126FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03094829
127KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02592532
128HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02469028
129KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00046289
130GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99237275
131BCL6_27268052_Chip-Seq_Bcells_Human0.98560175
132CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97803174
133THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97036206
134SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96976345
135FUS_26573619_Chip-Seq_HEK293_Human0.96806858
136CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96793308
137TAF15_26573619_Chip-Seq_HEK293_Human0.96753837
138GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96739151
139TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96650059
140NANOG_19829295_ChIP-Seq_ESCs_Human0.96180196
141SOX2_19829295_ChIP-Seq_ESCs_Human0.96180196
142HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95895046
143ERG_20517297_ChIP-Seq_VCAP_Human0.94265882
144GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93849535
145NCOR_22424771_ChIP-Seq_293T_Human0.93676137
146OCT4_20526341_ChIP-Seq_ESCs_Human0.92423278
147ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92086108
148YY1_22570637_ChIP-Seq_MALME-3M_Human0.91441307
149PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91082130
150KDM5A_27292631_Chip-Seq_BREAST_Human0.90917139
151E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90711310
152GBX2_23144817_ChIP-Seq_PC3_Human0.88848627
153CEBPB_22108803_ChIP-Seq_LS180_Human0.88486098
154EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88256671
155P300_27268052_Chip-Seq_Bcells_Human0.88230885
156SALL4_22934838_ChIP-ChIP_CD34+_Human0.88147903
157EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.88138640
158PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87330649

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.23301864
2MP0008057_abnormal_DNA_replication3.66459856
3MP0003718_maternal_effect3.49567627
4MP0002148_abnormal_hypersensitivity_rea3.09144717
5MP0000685_abnormal_immune_system3.07748705
6MP0010094_abnormal_chromosome_stability2.74612517
7MP0003436_decreased_susceptibility_to2.72525004
8MP0009785_altered_susceptibility_to2.72006582
9MP0005671_abnormal_response_to2.70104653
10MP0008058_abnormal_DNA_repair2.39473515
11MP0003693_abnormal_embryo_hatching2.32755770
12MP0009697_abnormal_copulation2.31131309
13MP0005000_abnormal_immune_tolerance2.29670533
14MP0003077_abnormal_cell_cycle2.28775373
15MP0001545_abnormal_hematopoietic_system2.26536472
16MP0005397_hematopoietic_system_phenotyp2.26536472
17MP0004957_abnormal_blastocyst_morpholog2.22511051
18MP0003111_abnormal_nucleus_morphology2.21200564
19MP0005410_abnormal_fertilization2.18466311
20MP0001800_abnormal_humoral_immune2.10627249
21MP0006082_CNS_inflammation2.10383791
22MP0006035_abnormal_mitochondrial_morpho2.10248552
23MP0006036_abnormal_mitochondrial_physio2.09929862
24MP0005025_abnormal_response_to2.09014438
25MP0001853_heart_inflammation2.08606593
26MP0002452_abnormal_antigen_presenting2.06192759
27MP0001348_abnormal_lacrimal_gland2.02322281
28MP0005387_immune_system_phenotype2.00014666
29MP0001790_abnormal_immune_system2.00014666
30MP0008877_abnormal_DNA_methylation1.96991476
31MP0008004_abnormal_stomach_pH1.95865677
32MP0002723_abnormal_immune_serum1.94936714
33MP0002736_abnormal_nociception_after1.89201349
34MP0008007_abnormal_cellular_replicative1.82905526
35MP0002396_abnormal_hematopoietic_system1.82863401
36MP0001819_abnormal_immune_cell1.81760993
37MP0002398_abnormal_bone_marrow1.78513534
38MP0002420_abnormal_adaptive_immunity1.77555658
39MP0010307_abnormal_tumor_latency1.77346572
40MP0002419_abnormal_innate_immunity1.77324504
41MP0003136_yellow_coat_color1.73800981
42MP0002163_abnormal_gland_morphology1.71971359
43MP0002405_respiratory_system_inflammati1.68458676
44MP0000465_gastrointestinal_hemorrhage1.65972382
45MP0000015_abnormal_ear_pigmentation1.62726369
46MP0000372_irregular_coat_pigmentation1.61230983
47MP0010352_gastrointestinal_tract_polyps1.60641141
48MP0000716_abnormal_immune_system1.58629914
49MP0006276_abnormal_autonomic_nervous1.58210217
50MP0003186_abnormal_redox_activity1.57289202
51MP0004808_abnormal_hematopoietic_stem1.51880679
52MP0000490_abnormal_crypts_of1.50334328
53MP0000689_abnormal_spleen_morphology1.49313280
54MP0003786_premature_aging1.48482542
55MP0005646_abnormal_pituitary_gland1.45915391
56MP0002429_abnormal_blood_cell1.45584351
57MP0003448_altered_tumor_morphology1.44614974
58MP0005645_abnormal_hypothalamus_physiol1.44356295
59MP0009333_abnormal_splenocyte_physiolog1.44235273
60MP0001929_abnormal_gametogenesis1.42066858
61MP0005310_abnormal_salivary_gland1.42053726
62MP0002210_abnormal_sex_determination1.41757832
63MP0005551_abnormal_eye_electrophysiolog1.41028635
64MP0003656_abnormal_erythrocyte_physiolo1.40971890
65MP0001968_abnormal_touch/_nociception1.40852355
66MP0002722_abnormal_immune_system1.40848699
67MP0008875_abnormal_xenobiotic_pharmacok1.37988709
68MP0000350_abnormal_cell_proliferation1.32981544
69MP0008872_abnormal_physiological_respon1.32604342
70MP0002160_abnormal_reproductive_system1.31428776
71MP0005058_abnormal_lysosome_morphology1.31267011
72MP0009278_abnormal_bone_marrow1.28506427
73MP0002006_tumorigenesis1.27086273
74MP0000313_abnormal_cell_death1.25663023
75MP0001845_abnormal_inflammatory_respons1.24967559
76MP0004147_increased_porphyrin_level1.22308149
77MP0001145_abnormal_male_reproductive1.21924382
78MP0005167_abnormal_blood-brain_barrier1.21421589
79MP0002019_abnormal_tumor_incidence1.20941887
80MP0000858_altered_metastatic_potential1.20301305
81MP0002166_altered_tumor_susceptibility1.16932007
82MP0001764_abnormal_homeostasis1.16866757
83MP0005464_abnormal_platelet_physiology1.14725362
84MP0005647_abnormal_sex_gland1.14200137
85MP0003724_increased_susceptibility_to1.14011826
86MP0003763_abnormal_thymus_physiology1.13933145
87MP0010155_abnormal_intestine_physiology1.13258420
88MP0005084_abnormal_gallbladder_morpholo1.10967289
89MP0008469_abnormal_protein_level1.10606029
90MP0005389_reproductive_system_phenotype1.09750910
91MP0003303_peritoneal_inflammation1.09491279
92MP0005395_other_phenotype1.08203388
93MP0005076_abnormal_cell_differentiation1.07764786
94MP0003698_abnormal_male_reproductive1.07178840
95MP0008932_abnormal_embryonic_tissue1.06533127
96MP0003879_abnormal_hair_cell1.06156652
97MP0001533_abnormal_skeleton_physiology1.06066460
98MP0000230_abnormal_systemic_arterial1.05631676
99MP0004510_myositis1.05581730
100MP0002733_abnormal_thermal_nociception1.04606731
101MP0003878_abnormal_ear_physiology1.03659429
102MP0005377_hearing/vestibular/ear_phenot1.03659429
103MP0009764_decreased_sensitivity_to1.03551473
104MP0000343_altered_response_to1.03550767
105MP0002161_abnormal_fertility/fecundity0.98446146
106MP0002735_abnormal_chemical_nociception0.97747920
107MP0000703_abnormal_thymus_morphology0.97740436
108MP0000653_abnormal_sex_gland0.94419232
109MP0008775_abnormal_heart_ventricle0.93888285
110MP0001986_abnormal_taste_sensitivity0.90973646
111MP0004947_skin_inflammation0.90675936
112MP0001661_extended_life_span0.90480958
113MP0003806_abnormal_nucleotide_metabolis0.89805146
114MP0002638_abnormal_pupillary_reflex0.87662512
115MP0005083_abnormal_biliary_tract0.86803765
116MP0002277_abnormal_respiratory_mucosa0.85046452
117MP0003699_abnormal_female_reproductive0.83945031
118MP0001730_embryonic_growth_arrest0.83748007
119MP0003638_abnormal_response/metabolism_0.80651556
120MP0002090_abnormal_vision0.79353005
121MP0001485_abnormal_pinna_reflex0.78510042
122MP0001970_abnormal_pain_threshold0.78353410
123MP0001293_anophthalmia0.78064722
124MP0001346_abnormal_lacrimal_gland0.77974916
125MP0002933_joint_inflammation0.77245486
126MP0003123_paternal_imprinting0.76520352
127MP0009765_abnormal_xenobiotic_induced0.76330525
128MP0003566_abnormal_cell_adhesion0.76252391
129MP0003646_muscle_fatigue0.75834498
130MP0005535_abnormal_body_temperature0.75136992
131MP0002138_abnormal_hepatobiliary_system0.74793328
132MP0003941_abnormal_skin_development0.74792310
133MP0004782_abnormal_surfactant_physiolog0.72897861
134MP0001119_abnormal_female_reproductive0.71678776
135MP0002132_abnormal_respiratory_system0.71442829
136MP0005174_abnormal_tail_pigmentation0.71387474
137MP0006292_abnormal_olfactory_placode0.70534021
138MP0000371_diluted_coat_color0.69738826
139MP0000358_abnormal_cell_content/0.69663093
140MP0002282_abnormal_trachea_morphology0.69547311
141MP0009763_increased_sensitivity_to0.67553139
142MP0001915_intracranial_hemorrhage0.67042672
143MP0005075_abnormal_melanosome_morpholog0.65872488
144MP0008995_early_reproductive_senescence0.65649830
145MP0005621_abnormal_cell_physiology0.64824801

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)4.72995022
2Prolonged bleeding time (HP:0003010)4.21692216
33-Methylglutaconic aciduria (HP:0003535)4.17902257
4Dyschromatopsia (HP:0007641)4.15165760
5Severe visual impairment (HP:0001141)4.15128170
6Irregular epiphyses (HP:0010582)3.96158167
7Autoimmune thrombocytopenia (HP:0001973)3.80219660
8Generalized aminoaciduria (HP:0002909)3.61969756
9Nasal polyposis (HP:0100582)3.48335848
10Recurrent abscess formation (HP:0002722)3.45423048
11Congenital stationary night blindness (HP:0007642)3.32740513
12Purpura (HP:0000979)3.25028040
13Abnormal rod and cone electroretinograms (HP:0008323)3.19826346
14Hepatocellular necrosis (HP:0001404)3.14063176
15Hepatic necrosis (HP:0002605)3.13881019
16Recurrent bacterial skin infections (HP:0005406)3.11055935
17Elevated erythrocyte sedimentation rate (HP:0003565)3.06517269
18Birth length less than 3rd percentile (HP:0003561)3.05114466
19Eczematoid dermatitis (HP:0000976)3.04989440
20Menorrhagia (HP:0000132)3.01908020
21Amaurosis fugax (HP:0100576)2.94852751
22Abnormal number of erythroid precursors (HP:0012131)2.94251369
23Abnormality of the nasal mucosa (HP:0000433)2.94094889
24Thrombocytosis (HP:0001894)2.93604159
25Chromsome breakage (HP:0040012)2.88002436
26Abnormality of cells of the erythroid lineage (HP:0012130)2.84114247
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.82982781
28Recurrent bronchitis (HP:0002837)2.81243257
29Mediastinal lymphadenopathy (HP:0100721)2.78790847
30Agnosia (HP:0010524)2.78695233
31Increased mean platelet volume (HP:0011877)2.72058033
32Epistaxis (HP:0000421)2.68571659
33Vasculitis (HP:0002633)2.68514293
34Myositis (HP:0100614)2.67668783
35Central scotoma (HP:0000603)2.62958090
36Aplasia/Hypoplasia of the fovea (HP:0008060)2.58052395
37Hypoplasia of the fovea (HP:0007750)2.58052395
38Attenuation of retinal blood vessels (HP:0007843)2.57046999
39Abnormal platelet volume (HP:0011876)2.55996020
40Degeneration of anterior horn cells (HP:0002398)2.55533602
41Abnormality of the anterior horn cell (HP:0006802)2.55533602
42Cleft eyelid (HP:0000625)2.55190547
43Decreased central vision (HP:0007663)2.54227956
44Carpal bone hypoplasia (HP:0001498)2.54062035
45Recurrent viral infections (HP:0004429)2.53278126
46Abnormal spermatogenesis (HP:0008669)2.52330393
47Mitochondrial inheritance (HP:0001427)2.52310380
48Poor head control (HP:0002421)2.51736950
49Recurrent fungal infections (HP:0002841)2.51126645
50Hypochromic anemia (HP:0001931)2.48859593
51Gastrointestinal infarctions (HP:0005244)2.48402450
52Acute necrotizing encephalopathy (HP:0006965)2.48078913
53Abnormality of T cell physiology (HP:0011840)2.47284917
54Type I transferrin isoform profile (HP:0003642)2.46195036
55Increased CSF lactate (HP:0002490)2.45109300
56Reticulocytopenia (HP:0001896)2.44662534
57Dynein arm defect of respiratory motile cilia (HP:0012255)2.44259292
58Absent/shortened dynein arms (HP:0200106)2.44259292
59Myelodysplasia (HP:0002863)2.43994807
60True hermaphroditism (HP:0010459)2.41051260
61Orchitis (HP:0100796)2.40653320
62Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.40194276
63Absent epiphyses (HP:0010577)2.40194276
64Abnormal pupillary function (HP:0007686)2.39619817
65Stomatitis (HP:0010280)2.38339554
66Metaphyseal cupping (HP:0003021)2.38098589
67Abnormality of the fovea (HP:0000493)2.37815424
68Abnormality of the heme biosynthetic pathway (HP:0010472)2.36985611
69Hypergammaglobulinemia (HP:0010702)2.36863051
70Recurrent gram-negative bacterial infections (HP:0005420)2.35921139
71Flat capital femoral epiphysis (HP:0003370)2.34711040
72Abnormality of alanine metabolism (HP:0010916)2.32401587
73Hyperalaninemia (HP:0003348)2.32401587
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32401587
75IgA deficiency (HP:0002720)2.31987307
76Aplasia/Hypoplasia of the uvula (HP:0010293)2.31727886
77Retrobulbar optic neuritis (HP:0100654)2.28882526
78Optic neuritis (HP:0100653)2.28882526
79Meckel diverticulum (HP:0002245)2.27460127
80Acute encephalopathy (HP:0006846)2.26249380
81Basal ganglia calcification (HP:0002135)2.24750178
82Abnormality of macular pigmentation (HP:0008002)2.24631180
83Abnormal mitochondria in muscle tissue (HP:0008316)2.22392775
84Abnormality of the ileum (HP:0001549)2.21996545
85Abnormal protein glycosylation (HP:0012346)2.21037184
86Abnormal glycosylation (HP:0012345)2.21037184
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21037184
88Abnormal protein N-linked glycosylation (HP:0012347)2.21037184
89Paralysis (HP:0003470)2.20406135
90Abnormality of chromosome stability (HP:0003220)2.20198592
91Petechiae (HP:0000967)2.18963973
92Molar tooth sign on MRI (HP:0002419)2.16896993
93Abnormality of midbrain morphology (HP:0002418)2.16896993
94Small epiphyses (HP:0010585)2.15771211
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.15201153
96Tongue fasciculations (HP:0001308)2.13975616
97Decreased electroretinogram (ERG) amplitude (HP:0000654)2.13917441
98Supernumerary spleens (HP:0009799)2.13587485
99Abnormality of macrophages (HP:0004311)2.12962256
100Hyperlipoproteinemia (HP:0010980)2.12883639
101Pancreatic cysts (HP:0001737)2.12864426
102Impaired platelet aggregation (HP:0003540)2.12427907
103Abnormal platelet function (HP:0011869)2.12427907
104Increased serum lactate (HP:0002151)2.12319754
105Abnormality of the preputium (HP:0100587)2.10802142
106Bronchitis (HP:0012387)2.10620798
107Albinism (HP:0001022)2.10466510
108Bile duct proliferation (HP:0001408)2.09953877
109Abnormal biliary tract physiology (HP:0012439)2.09953877
11011 pairs of ribs (HP:0000878)2.09149944
111Abnormality of lateral ventricle (HP:0030047)2.09085190
112Microvesicular hepatic steatosis (HP:0001414)2.08098408
113Abolished electroretinogram (ERG) (HP:0000550)2.07545815
114Abnormal ciliary motility (HP:0012262)2.07475467
115Recurrent lower respiratory tract infections (HP:0002783)2.04583601
116Chronic otitis media (HP:0000389)2.04022442
117Hypoplasia of the capital femoral epiphysis (HP:0003090)2.02943901
118Abnormality of T cells (HP:0002843)2.02001187
119Pancreatic fibrosis (HP:0100732)2.01933536
120Autoimmune hemolytic anemia (HP:0001890)2.01488223
121Granulocytopenia (HP:0001913)2.01163848
122Selective tooth agenesis (HP:0001592)1.99863088
123Epiphyseal dysplasia (HP:0002656)1.99824983
124CNS demyelination (HP:0007305)1.99620690
125Abnormal delayed hypersensitivity skin test (HP:0002963)1.98649444
126Spinal muscular atrophy (HP:0007269)1.97647743
127Cellulitis (HP:0100658)1.97355588
128Abnormal respiratory motile cilium physiology (HP:0012261)1.97002927
129Multiple enchondromatosis (HP:0005701)1.96837017
130Male infertility (HP:0003251)1.96705661
131Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96355698
132Vacuolated lymphocytes (HP:0001922)1.94654023
133Vitreoretinal degeneration (HP:0000655)1.94576309
134Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.94080345
135Decreased activity of mitochondrial respiratory chain (HP:0008972)1.94080345
136Abnormal respiratory epithelium morphology (HP:0012253)1.93810345
137Abnormal respiratory motile cilium morphology (HP:0005938)1.93810345
138Progressive macrocephaly (HP:0004481)1.93295867
139Renal Fanconi syndrome (HP:0001994)1.92398099
140Clubbing of toes (HP:0100760)1.92385226
141Pallor (HP:0000980)1.92274827
142IgG deficiency (HP:0004315)1.90863058
143Azoospermia (HP:0000027)1.90332398
144Recurrent pneumonia (HP:0006532)1.90173922
145Mesangial abnormality (HP:0001966)1.88492226
146Ependymoma (HP:0002888)1.88196032
147Lactic acidosis (HP:0003128)1.88118310
148Anorexia (HP:0002039)1.88058173
149Gonadotropin excess (HP:0000837)1.87292513
150Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.86888176
151Abnormality of femoral epiphyses (HP:0006499)1.86888176
152Hypergonadotropic hypogonadism (HP:0000815)1.85589230
153Leukopenia (HP:0001882)1.85339571
154Eosinophilia (HP:0001880)1.84829207
155Nephronophthisis (HP:0000090)1.84575440
156Bone marrow hypocellularity (HP:0005528)1.84415137
157Male pseudohermaphroditism (HP:0000037)1.84144898
158Increased neuronal autofluorescent lipopigment (HP:0002074)1.84021528
159Aplastic anemia (HP:0001915)1.83868369
160Recurrent skin infections (HP:0001581)1.82753929
161Scotoma (HP:0000575)1.82575686
162Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.81550940
163Pustule (HP:0200039)1.80838145
164Abnormality of the epiphysis of the femoral head (HP:0010574)1.80758762
165Nausea (HP:0002018)1.80643808
166Median cleft lip (HP:0000161)1.80190068
167Obstructive lung disease (HP:0006536)1.79878091
168Chronic obstructive pulmonary disease (HP:0006510)1.79878091
169Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.79466513
170Absent thumb (HP:0009777)1.78630161
171Premature ovarian failure (HP:0008209)1.77415628
172Respiratory failure (HP:0002878)1.77404583
173Glossoptosis (HP:0000162)1.77197185
174Chronic sinusitis (HP:0011109)1.76826241
175Porencephaly (HP:0002132)1.76658913
176Delusions (HP:0000746)1.73740833
177Progressive inability to walk (HP:0002505)1.71976863
178Absent rod-and cone-mediated responses on ERG (HP:0007688)1.71973391
179Gingival bleeding (HP:0000225)1.71887130
180Conjunctival telangiectasia (HP:0000524)1.71614618
181Horizontal nystagmus (HP:0000666)1.70664115
182Hyperventilation (HP:0002883)1.70354415
183Abnormality of the renal medulla (HP:0100957)1.69015993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.59695268
2MAP3K143.14809254
3PIM23.13271318
4PBK2.96035498
5NUAK12.73928279
6TAOK32.71380174
7IKBKB2.54048606
8EIF2AK12.41482617
9WEE12.37994528
10CDC72.29459092
11TBK12.28851466
12FRK2.21394881
13MAP4K22.12609336
14TESK12.09044329
15PNCK2.08221889
16IRAK42.08067960
17CDK192.07390015
18MAP4K12.00354664
19VRK21.99496393
20TYK21.90537444
21PIM11.89838925
22STK41.82495175
23NEK21.81138526
24JAK31.80757968
25IRAK31.72387342
26PTK2B1.68753558
27NME21.68509334
28BLK1.65397187
29CHUK1.63953561
30FGR1.59245529
31BUB11.56239057
32MAP3K131.50360419
33IKBKE1.45904514
34CDK71.45744088
35OXSR11.43823195
36RPS6KA41.42555166
37CSF1R1.42354885
38STK101.40759389
39RIPK41.40356190
40PIK3CG1.38200537
41KIT1.37736881
42ATR1.37212975
43STK161.35770767
44PLK11.30201590
45ACVR1B1.29810383
46MATK1.28416591
47WNK31.27959675
48MAP3K111.27478640
49NME11.24145779
50VRK11.17595581
51PLK21.12861634
52TXK1.11249527
53EIF2AK21.11228015
54FLT31.09615153
55PLK41.09559145
56TRIM281.07883775
57STK391.04800390
58BMPR1B1.04144160
59TTK1.03516250
60MAP3K121.01087253
61TLK11.00654769
62CDK40.99792480
63KDR0.99665884
64PDK30.99555326
65PDK40.99555326
66PDK20.98696229
67SYK0.98654589
68MST40.93872976
69EIF2AK30.93699049
70SRPK10.89643072
71PAK40.88341167
72TGFBR20.88101982
73ARAF0.87923661
74TNIK0.85080685
75TNK20.84938557
76TAF10.84628168
77BCKDK0.84394897
78YES10.83495117
79BTK0.83255741
80ABL20.83215537
81ADRBK20.83133389
82CSNK1G30.82158754
83MARK30.82098850
84CHEK10.82018290
85PLK30.81588352
86TESK20.81201334
87DYRK30.80899153
88AURKB0.80543031
89SCYL20.78571581
90CHEK20.77742708
91BRSK20.77716423
92MYLK0.77230433
93CCNB10.77212383
94TRPM70.76855791
95ZAP700.75264650
96PASK0.75255436
97MAP3K80.74725889
98RPS6KB20.74040654
99MET0.73342460
100TGFBR10.72644672
101CSNK1G10.71869393
102LYN0.71697794
103PRKCI0.69868903
104CSK0.69342568
105ICK0.68371177
106ERN10.67976241
107CDK60.67018159
108GRK50.66948142
109MOS0.65083831
110BMPR20.64674126
111MKNK20.64047795
112NEK90.63326608
113ATM0.62550908
114GRK60.62385020
115MAPKAPK30.62370817
116ZAK0.61787186
117DAPK10.61664709
118MKNK10.60271542
119ADRBK10.60249642
120DYRK1B0.59564964
121GRK70.57949927
122PAK10.57864166
123BRD40.57284919
124MAP3K30.56911331
125BMX0.56675014
126JAK10.56579127
127MST1R0.55168244
128TEC0.54607922
129STK30.53150363
130PRKG20.52230390
131IRAK10.52001166
132PRKCD0.50064467
133STK240.49468938
134CSNK1G20.48976959
135RPS6KA50.48444991
136LCK0.47527717
137CDK20.45169626
138CSNK2A10.44250363
139DYRK20.42462732
140BRSK10.41982453
141MAP3K50.41639744
142HCK0.41457642
143GRK10.41435794
144DAPK30.39957010
145PINK10.38996084
146FER0.36632445
147CAMK1G0.36118258
148ITK0.35262319
149AURKA0.35064463
150FES0.34450495
151WNK40.33487345

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.59822714
2Allograft rejection_Homo sapiens_hsa053303.49472863
3Mismatch repair_Homo sapiens_hsa034302.93073450
4Proteasome_Homo sapiens_hsa030502.76531470
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.67983131
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.64649159
7Ribosome_Homo sapiens_hsa030102.38743304
8Base excision repair_Homo sapiens_hsa034102.33813702
9Graft-versus-host disease_Homo sapiens_hsa053322.33643912
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.28072124
11Homologous recombination_Homo sapiens_hsa034402.23214630
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.08022561
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.01902003
14Olfactory transduction_Homo sapiens_hsa047401.98979000
15RNA polymerase_Homo sapiens_hsa030201.87417806
16RNA transport_Homo sapiens_hsa030131.86711031
17Legionellosis_Homo sapiens_hsa051341.86100613
18One carbon pool by folate_Homo sapiens_hsa006701.86028261
19Nucleotide excision repair_Homo sapiens_hsa034201.84854288
20Autoimmune thyroid disease_Homo sapiens_hsa053201.84615567
21Herpes simplex infection_Homo sapiens_hsa051681.84255373
22Type I diabetes mellitus_Homo sapiens_hsa049401.78913702
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.78783167
24Fatty acid elongation_Homo sapiens_hsa000621.76582484
25Oxidative phosphorylation_Homo sapiens_hsa001901.75594970
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.70668749
27Leishmaniasis_Homo sapiens_hsa051401.69504288
28Parkinsons disease_Homo sapiens_hsa050121.69281349
29Spliceosome_Homo sapiens_hsa030401.69145695
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.65309616
31Fanconi anemia pathway_Homo sapiens_hsa034601.61557290
32Basal transcription factors_Homo sapiens_hsa030221.59962101
33Antigen processing and presentation_Homo sapiens_hsa046121.58721693
34Measles_Homo sapiens_hsa051621.56057738
35Non-homologous end-joining_Homo sapiens_hsa034501.53519664
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52614379
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.51744759
38Pyrimidine metabolism_Homo sapiens_hsa002401.49797158
39Cell cycle_Homo sapiens_hsa041101.44860389
40Influenza A_Homo sapiens_hsa051641.42682199
41Platelet activation_Homo sapiens_hsa046111.37782758
42p53 signaling pathway_Homo sapiens_hsa041151.36714568
43Sulfur metabolism_Homo sapiens_hsa009201.36644847
44Asthma_Homo sapiens_hsa053101.29314040
45Collecting duct acid secretion_Homo sapiens_hsa049661.29209249
46Huntingtons disease_Homo sapiens_hsa050161.28841377
47Primary immunodeficiency_Homo sapiens_hsa053401.26933047
48Epstein-Barr virus infection_Homo sapiens_hsa051691.20315070
49Apoptosis_Homo sapiens_hsa042101.19888470
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19324585
51Regulation of autophagy_Homo sapiens_hsa041401.17709851
52Phototransduction_Homo sapiens_hsa047441.16527316
53RNA degradation_Homo sapiens_hsa030181.12126719
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11860371
55Propanoate metabolism_Homo sapiens_hsa006401.10136793
56Sulfur relay system_Homo sapiens_hsa041221.09234821
57Malaria_Homo sapiens_hsa051441.06460483
58Viral myocarditis_Homo sapiens_hsa054161.04392414
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02888924
60Ether lipid metabolism_Homo sapiens_hsa005651.02773606
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02572966
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01864049
63Linoleic acid metabolism_Homo sapiens_hsa005911.01048418
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99317973
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96600309
66Systemic lupus erythematosus_Homo sapiens_hsa053220.96493923
67Toxoplasmosis_Homo sapiens_hsa051450.96209009
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.96076636
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92681863
70TNF signaling pathway_Homo sapiens_hsa046680.91947526
71Shigellosis_Homo sapiens_hsa051310.91925622
72Caffeine metabolism_Homo sapiens_hsa002320.90903737
73Viral carcinogenesis_Homo sapiens_hsa052030.90422883
74Chemical carcinogenesis_Homo sapiens_hsa052040.90369597
75Tryptophan metabolism_Homo sapiens_hsa003800.89829254
76beta-Alanine metabolism_Homo sapiens_hsa004100.89528018
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88886995
78Peroxisome_Homo sapiens_hsa041460.88294207
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87340563
80B cell receptor signaling pathway_Homo sapiens_hsa046620.85293718
81Pertussis_Homo sapiens_hsa051330.84813383
82African trypanosomiasis_Homo sapiens_hsa051430.83329570
83mRNA surveillance pathway_Homo sapiens_hsa030150.80740788
84Osteoclast differentiation_Homo sapiens_hsa043800.79219807
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78981196
86Tuberculosis_Homo sapiens_hsa051520.76666827
87Hematopoietic cell lineage_Homo sapiens_hsa046400.75005640
88Hepatitis B_Homo sapiens_hsa051610.73010995
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.71242263
90Metabolic pathways_Homo sapiens_hsa011000.70497561
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70172629
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69705973
93Rheumatoid arthritis_Homo sapiens_hsa053230.69213251
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69190187
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69039608
96Purine metabolism_Homo sapiens_hsa002300.68133689
97Acute myeloid leukemia_Homo sapiens_hsa052210.67580670
98Staphylococcus aureus infection_Homo sapiens_hsa051500.64921536
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.64777404
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64744593
101Folate biosynthesis_Homo sapiens_hsa007900.63789414
102Other glycan degradation_Homo sapiens_hsa005110.63118510
103Nitrogen metabolism_Homo sapiens_hsa009100.62890909
104HTLV-I infection_Homo sapiens_hsa051660.59317246
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.57169201
106Oocyte meiosis_Homo sapiens_hsa041140.55248974
107Pentose phosphate pathway_Homo sapiens_hsa000300.54232990
108Butanoate metabolism_Homo sapiens_hsa006500.54160994
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54126586
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53117312
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53098234
112Alzheimers disease_Homo sapiens_hsa050100.52932800
113Fructose and mannose metabolism_Homo sapiens_hsa000510.52825731
114Salmonella infection_Homo sapiens_hsa051320.52822782
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51924873
116Retinol metabolism_Homo sapiens_hsa008300.51467498
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.51385308
118Arachidonic acid metabolism_Homo sapiens_hsa005900.51006810
119Chemokine signaling pathway_Homo sapiens_hsa040620.50510672
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47723657
121Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47457631
122Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46985681
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46075823
124Small cell lung cancer_Homo sapiens_hsa052220.45754693
125N-Glycan biosynthesis_Homo sapiens_hsa005100.45050101
126Sphingolipid metabolism_Homo sapiens_hsa006000.44942526
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44108804
128Selenocompound metabolism_Homo sapiens_hsa004500.43827163
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.42625369
130Glycerolipid metabolism_Homo sapiens_hsa005610.42270958
131ABC transporters_Homo sapiens_hsa020100.39643530
132Taste transduction_Homo sapiens_hsa047420.38125672
133Serotonergic synapse_Homo sapiens_hsa047260.37564588
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34807461
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34706674
136Glutathione metabolism_Homo sapiens_hsa004800.33132559
137Glycosaminoglycan degradation_Homo sapiens_hsa005310.32101173
138Phagosome_Homo sapiens_hsa041450.29830355
139Hepatitis C_Homo sapiens_hsa051600.27943472
140Protein export_Homo sapiens_hsa030600.26824621
141HIF-1 signaling pathway_Homo sapiens_hsa040660.26687730
142Lysosome_Homo sapiens_hsa041420.26616259
143Chronic myeloid leukemia_Homo sapiens_hsa052200.24689336
144Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24040812
145Notch signaling pathway_Homo sapiens_hsa043300.21568188
146Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21399966
147Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.19234401
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19212137
149Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18672876

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