MAB21L3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma secretion (GO:0072643)7.22732170
2regulation of activation of Janus kinase activity (GO:0010533)6.73761257
3positive regulation of T-helper cell differentiation (GO:0045624)5.54013042
4regulation of memory T cell differentiation (GO:0043380)5.40132757
5regulation of T-helper 1 cell differentiation (GO:0045625)5.33891425
6regulation of RIG-I signaling pathway (GO:0039535)5.29648731
7regulation of hypersensitivity (GO:0002883)5.12265987
8positive regulation of interleukin-12 production (GO:0032735)5.09777411
9positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)5.04559273
10regulation of dendritic cell antigen processing and presentation (GO:0002604)4.88632046
11T-helper 1 type immune response (GO:0042088)4.87916118
12behavioral response to nicotine (GO:0035095)4.86609251
13positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.61172443
14antigen processing and presentation of endogenous antigen (GO:0019883)4.47385641
15regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.42196127
16positive regulation of alpha-beta T cell proliferation (GO:0046641)4.41882680
17regulation of T-helper 2 cell differentiation (GO:0045628)4.36171819
18positive regulation of type 2 immune response (GO:0002830)4.34802336
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.34346745
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.34346745
21regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.31892325
22NIK/NF-kappaB signaling (GO:0038061)4.26801628
23regulation of T-helper cell differentiation (GO:0045622)4.22914239
24positive regulation of interleukin-17 production (GO:0032740)4.20435624
25regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)4.16552176
26regulation of alpha-beta T cell proliferation (GO:0046640)4.03872418
27keratinization (GO:0031424)3.95899525
28growth hormone receptor signaling pathway (GO:0060396)3.94395016
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.92598584
30neutrophil activation involved in immune response (GO:0002283)3.88511148
31citrulline biosynthetic process (GO:0019240)3.88480197
32positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.88414659
33positive regulation of natural killer cell differentiation (GO:0032825)3.88329911
34positive regulation of pseudopodium assembly (GO:0031274)3.86847511
35central nervous system myelination (GO:0022010)3.86128335
36axon ensheathment in central nervous system (GO:0032291)3.86128335
37response to muramyl dipeptide (GO:0032495)3.84663161
38type I interferon signaling pathway (GO:0060337)3.83545109
39cellular response to type I interferon (GO:0071357)3.83545109
40hemidesmosome assembly (GO:0031581)3.82582419
41positive regulation of humoral immune response (GO:0002922)3.81361495
42positive regulation of antigen processing and presentation (GO:0002579)3.76811325
43positive regulation of response to biotic stimulus (GO:0002833)3.76363399
44response to type I interferon (GO:0034340)3.76348873
45regulation of interleukin-12 biosynthetic process (GO:0045075)3.75237050
46epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.74702353
47regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.74515050
48establishment of protein localization to Golgi (GO:0072600)3.74037468
49positive regulation of activated T cell proliferation (GO:0042104)3.70956076
50positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.68737590
51negative regulation of protein localization to cell surface (GO:2000009)3.65573757
52regulation of interleukin-12 production (GO:0032655)3.64957214
53pyrimidine nucleobase catabolic process (GO:0006208)3.63819303
54negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.62646463
55myeloid dendritic cell differentiation (GO:0043011)3.61791925
56gamma-aminobutyric acid transport (GO:0015812)3.57654444
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.55401326
58regulation of T cell tolerance induction (GO:0002664)3.52329078
59keratinocyte differentiation (GO:0030216)3.50684934
60positive regulation of developmental pigmentation (GO:0048087)3.44614711
61positive regulation of interferon-alpha production (GO:0032727)3.44390498
62positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.42208123
63cytokine secretion (GO:0050663)3.42158315
64neutrophil activation (GO:0042119)3.41358481
65positive regulation of T-helper 1 type immune response (GO:0002827)3.40992966
66regulation of T-helper 1 type immune response (GO:0002825)3.38069510
67regulation of pseudopodium assembly (GO:0031272)3.37360138
68cell proliferation in forebrain (GO:0021846)3.35562842
69positive regulation of interleukin-2 production (GO:0032743)3.35480712
70tyrosine phosphorylation of STAT protein (GO:0007260)3.34535039
71axonal fasciculation (GO:0007413)3.32277732
72cellular response to growth hormone stimulus (GO:0071378)3.30897497
73nonmotile primary cilium assembly (GO:0035058)3.29134137
74postsynaptic membrane organization (GO:0001941)3.28771276
75negative regulation of interleukin-17 production (GO:0032700)3.28397005
76positive regulation of immune response to tumor cell (GO:0002839)3.28292440
77regulation of immune response to tumor cell (GO:0002837)3.28292440
78regulation of response to tumor cell (GO:0002834)3.28292440
79positive regulation of response to tumor cell (GO:0002836)3.28292440
80regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.27399821
81L-fucose catabolic process (GO:0042355)3.26335087
82fucose catabolic process (GO:0019317)3.26335087
83L-fucose metabolic process (GO:0042354)3.26335087
84positive regulation of defense response to virus by host (GO:0002230)3.24458352
85lung lobe morphogenesis (GO:0060463)3.22787622
86negative regulation of sodium ion transport (GO:0010766)3.21428971
87presynaptic membrane organization (GO:0097090)3.20144692
88granulocyte activation (GO:0036230)3.18800124
89regulation of interferon-alpha production (GO:0032647)3.17272510
90regulation of antigen processing and presentation (GO:0002577)3.17128318
91positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.16972368
92regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.14707356
93detection of light stimulus involved in sensory perception (GO:0050962)3.12979657
94detection of light stimulus involved in visual perception (GO:0050908)3.12979657
95regulation of pigment cell differentiation (GO:0050932)3.12609836
96response to interferon-alpha (GO:0035455)3.12264876
97regulation of interleukin-17 production (GO:0032660)3.11535027
98natural killer cell mediated immunity (GO:0002228)3.11500503
99natural killer cell mediated cytotoxicity (GO:0042267)3.11500503
100dendritic cell differentiation (GO:0097028)3.10557373
101retina layer formation (GO:0010842)3.10549681
102membrane depolarization during action potential (GO:0086010)3.10509702
103cellular response to interferon-alpha (GO:0035457)3.08855708
104hepatocyte apoptotic process (GO:0097284)3.08839132
105interferon-gamma-mediated signaling pathway (GO:0060333)3.08022271
106behavioral response to ethanol (GO:0048149)3.08006032
107sexual reproduction (GO:0019953)3.07989584
108natural killer cell differentiation (GO:0001779)3.05631153
109neuronal action potential propagation (GO:0019227)3.05166599
110indole-containing compound catabolic process (GO:0042436)3.05153977
111indolalkylamine catabolic process (GO:0046218)3.05153977
112tryptophan catabolic process (GO:0006569)3.05153977
113nucleobase catabolic process (GO:0046113)3.04757368
114myeloid dendritic cell activation (GO:0001773)3.02992967
115cerebral cortex radially oriented cell migration (GO:0021799)3.02792711
116response to prostaglandin E (GO:0034695)3.02782923
117regulation of immunoglobulin secretion (GO:0051023)3.02738238
118kynurenine metabolic process (GO:0070189)3.02168597
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.01885295
120activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.00447983
121presynaptic membrane assembly (GO:0097105)2.99917893
122substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.99360315
123substrate-independent telencephalic tangential migration (GO:0021826)2.99360315
124positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.97892630
125regulation of natural killer cell differentiation (GO:0032823)2.97524134
126neuron recognition (GO:0008038)2.96976219
127indolalkylamine metabolic process (GO:0006586)2.96937336
128antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.96440165
129startle response (GO:0001964)2.96146568
130negative regulation of systemic arterial blood pressure (GO:0003085)2.95329247
131positive regulation of interleukin-10 production (GO:0032733)2.95100961
132response to interferon-beta (GO:0035456)2.94639576
133protein polyglutamylation (GO:0018095)2.92662351
134response to protozoan (GO:0001562)2.92502383
135negative regulation of viral genome replication (GO:0045071)2.92187179
136positive regulation of toll-like receptor signaling pathway (GO:0034123)2.91204250
137limb development (GO:0060173)2.90262246
138appendage development (GO:0048736)2.90262246
139auditory receptor cell differentiation (GO:0042491)2.90007099
140regulation of inflammatory response to antigenic stimulus (GO:0002861)2.88917176
141snRNA transcription (GO:0009301)2.88020952
142response to interferon-gamma (GO:0034341)2.87882811
143somite development (GO:0061053)2.86565021
144positive regulation of astrocyte differentiation (GO:0048711)2.86364176
145dendritic spine morphogenesis (GO:0060997)2.86151725
146regulation of defense response to virus by host (GO:0050691)2.86104556
147cerebellar Purkinje cell differentiation (GO:0021702)2.85546367
148transmission of nerve impulse (GO:0019226)2.84876284
149CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.84428219
150T-helper cell differentiation (GO:0042093)2.84428219
151histone H3-K4 trimethylation (GO:0080182)2.84299102
152head development (GO:0060322)2.79828515
153negative regulation of translation, ncRNA-mediated (GO:0040033)2.77456417
154regulation of translation, ncRNA-mediated (GO:0045974)2.77456417
155negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.77456417
156regulation of sarcomere organization (GO:0060297)2.76139137
157short-term memory (GO:0007614)2.75886360
158central nervous system projection neuron axonogenesis (GO:0021952)2.75636575
159oxidative demethylation (GO:0070989)2.74938961
160epithelial cilium movement (GO:0003351)2.74502592
161ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.74046430
162negative regulation of astrocyte differentiation (GO:0048712)2.73739747
163regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.73123905
164mechanosensory behavior (GO:0007638)2.72887677
165positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.71995999
166adult walking behavior (GO:0007628)2.71034866
167detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.70971028
168neural tube formation (GO:0001841)2.70801706
169adaptation of signaling pathway (GO:0023058)2.69314739
170monoubiquitinated protein deubiquitination (GO:0035520)2.67668322
171positive regulation of sodium ion transmembrane transport (GO:1902307)2.67629323
172cardiovascular system development (GO:0072358)2.65079175
173neuronal action potential (GO:0019228)2.64879098
174auditory behavior (GO:0031223)2.64063913
175synaptic transmission, glutamatergic (GO:0035249)2.61271090
176intraciliary transport (GO:0042073)2.60652708
177protein localization to synapse (GO:0035418)2.60597127
178regulation of potassium ion transmembrane transporter activity (GO:1901016)2.59779068
179protein targeting to Golgi (GO:0000042)2.56208747
180serotonin metabolic process (GO:0042428)2.55787074
181regulation of action potential (GO:0098900)2.55579963
182response to pheromone (GO:0019236)2.55393228
183cilium organization (GO:0044782)2.53754488
184glutamate receptor signaling pathway (GO:0007215)2.53653501
185cilium movement (GO:0003341)2.53369318
186photoreceptor cell maintenance (GO:0045494)2.52779181
187cilium assembly (GO:0042384)2.49106287
188retinal ganglion cell axon guidance (GO:0031290)2.49042247
189retrograde transport, vesicle recycling within Golgi (GO:0000301)2.48553447
190tryptophan metabolic process (GO:0006568)2.47720727
191negative regulation of cytosolic calcium ion concentration (GO:0051481)2.47226821
192behavioral response to cocaine (GO:0048148)2.47035082
193kidney morphogenesis (GO:0060993)2.46829601
194neuron fate determination (GO:0048664)2.46681484
195cilium morphogenesis (GO:0060271)2.46546300
196regulation of cilium movement (GO:0003352)2.46292637
197positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.46253192
198neuron cell-cell adhesion (GO:0007158)2.45950794
199pattern specification involved in kidney development (GO:0061004)2.45484408
200central nervous system neuron axonogenesis (GO:0021955)2.44923056

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.27443677
2EZH2_22144423_ChIP-Seq_EOC_Human5.77179758
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.70839468
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.51822176
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.25840965
6RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.92921274
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.46538099
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.43675091
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.32989054
10GBX2_23144817_ChIP-Seq_PC3_Human3.32448508
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.11736945
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.04250164
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.97161468
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.77180761
15ESR1_15608294_ChIP-ChIP_MCF-7_Human2.72574284
16VDR_22108803_ChIP-Seq_LS180_Human2.64268252
17ZNF274_21170338_ChIP-Seq_K562_Hela2.52314049
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50852933
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.49055460
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.39003592
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.37513366
22ESR1_21235772_ChIP-Seq_MCF-7_Human2.31853030
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.29728336
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.24803699
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22203122
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.16595269
27TRIM28_21343339_ChIP-Seq_HEK293_Human2.10793387
28ZNF263_19887448_ChIP-Seq_K562_Human2.06379422
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06042054
30CBX2_27304074_Chip-Seq_ESCs_Mouse2.01986522
31REST_21632747_ChIP-Seq_MESCs_Mouse2.00156116
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98426602
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.96798304
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.93783099
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.93540051
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92744247
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91125715
38STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.90527200
39TAF15_26573619_Chip-Seq_HEK293_Human1.90007213
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86655304
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86585770
42IGF1R_20145208_ChIP-Seq_DFB_Human1.85630235
43P300_19829295_ChIP-Seq_ESCs_Human1.83705467
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82890038
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81157607
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.80713897
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.78406835
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76108257
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75660238
50SMAD4_21799915_ChIP-Seq_A2780_Human1.74566082
51DROSHA_22980978_ChIP-Seq_HELA_Human1.72414616
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.71349467
53SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.71349467
54SOX2_20726797_ChIP-Seq_SW620_Human1.69799367
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.67897683
56STAT3_23295773_ChIP-Seq_U87_Human1.67639036
57FUS_26573619_Chip-Seq_HEK293_Human1.66189932
58ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.64181954
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63679486
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.63679486
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.63671272
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.63528855
63EGR1_19032775_ChIP-ChIP_M12_Human1.62285882
64AR_21572438_ChIP-Seq_LNCaP_Human1.61189569
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60670799
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.60244824
67EWS_26573619_Chip-Seq_HEK293_Human1.59779357
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59236493
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56734087
70SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56213751
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56030973
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55980277
73TCF4_23295773_ChIP-Seq_U87_Human1.55235453
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54850433
75RNF2_27304074_Chip-Seq_ESCs_Mouse1.53915681
76EZH2_27294783_Chip-Seq_ESCs_Mouse1.53691936
77ER_23166858_ChIP-Seq_MCF-7_Human1.53195356
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52585968
79BCAT_22108803_ChIP-Seq_LS180_Human1.51497721
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51208055
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50225172
82TCF3_18692474_ChIP-Seq_MEFs_Mouse1.49734781
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47993291
84AR_25329375_ChIP-Seq_VCAP_Human1.47915505
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46778159
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46666521
87EED_16625203_ChIP-ChIP_MESCs_Mouse1.46235497
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.45585212
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44713099
90CBP_20019798_ChIP-Seq_JUKART_Human1.44713099
91TP53_16413492_ChIP-PET_HCT116_Human1.44386491
92RNF2_27304074_Chip-Seq_NSC_Mouse1.43536011
93NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42877847
94FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.41397502
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.40423139
96SALL1_21062744_ChIP-ChIP_HESCs_Human1.40051882
97SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.39241161
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37871133
99SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37188310
100PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37103458
101CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33563863
102RUNX2_22187159_ChIP-Seq_PCA_Human1.30718859
103VDR_24787735_ChIP-Seq_THP-1_Human1.30046158
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29785999
105EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27465996
106RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27465996
107ELK3_25401928_ChIP-Seq_HUVEC_Human1.26113191
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25642870
109IRF1_19129219_ChIP-ChIP_H3396_Human1.25434253
110CLOCK_20551151_ChIP-Seq_293T_Human1.25423383
111GATA4_25053715_ChIP-Seq_YYC3_Human1.25373925
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25283602
113GATA1_22025678_ChIP-Seq_K562_Human1.25032437
114REST_18959480_ChIP-ChIP_MESCs_Mouse1.24862398
115SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24589042
116CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23591610
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23574117
118MAF_26560356_Chip-Seq_TH1_Human1.23315948
119PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22558656
120SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22234328
121SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22118382
122PRDM14_20953172_ChIP-Seq_ESCs_Human1.22109311
123TCF4_22108803_ChIP-Seq_LS180_Human1.21615927
124PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19901678
125MYB_26560356_Chip-Seq_TH2_Human1.19794927
126SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19715157
127P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19641989
128CDX2_20551321_ChIP-Seq_CACO-2_Human1.19000483
129GATA6_25053715_ChIP-Seq_YYC3_Human1.18918519
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18824911
131KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18567326
132GATA2_21666600_ChIP-Seq_HMVEC_Human1.18298821
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17954347
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16772685
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16551953
136SMAD3_21741376_ChIP-Seq_ESCs_Human1.15461644
137ESR1_20079471_ChIP-ChIP_T-47D_Human1.14343657
138STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13760605
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11797958
140RACK7_27058665_Chip-Seq_MCF-7_Human1.11681828
141SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11433766
142MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11358890
143CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11300906
144FLI1_21867929_ChIP-Seq_TH2_Mouse1.11041116
145SOX2_21211035_ChIP-Seq_LN229_Gbm1.10913976
146TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10754574
147KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09404542
148SMAD4_21741376_ChIP-Seq_EPCs_Human1.09404064
149RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09310221
150EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07705716
151ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07513859
152TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07206908
153SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07176577
154NANOG_18555785_Chip-Seq_ESCs_Mouse1.07094169
155GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07028429
156P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06510661
157UBF1/2_26484160_Chip-Seq_HMECs_Human1.06107073
158AR_21909140_ChIP-Seq_LNCAP_Human1.05832441
159MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04941839
160KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04747210
161TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04389348
162ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04073606
163P53_22387025_ChIP-Seq_ESCs_Mouse1.03032175
164ARNT_22903824_ChIP-Seq_MCF-7_Human1.02014314
165TP53_22573176_ChIP-Seq_HFKS_Human1.01905833
166FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00289390
167CJUN_26792858_Chip-Seq_BT549_Human1.00275617
168CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99686867
169SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99420461
170OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98416883
171CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98234794
172MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97527770
173ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97300008
174NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97088247
175ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96001661
176BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95430108
177ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94902886
178JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93479748
179KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.92475684
180KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.92475684
181KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92475684
182ATF3_27146783_Chip-Seq_COLON_Human0.92322105
183* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92018072
184KLF5_25053715_ChIP-Seq_YYC3_Human0.91354380
185NANOG_18692474_ChIP-Seq_MEFs_Mouse0.89237098
186RUNX1_27514584_Chip-Seq_MCF-7_Human0.87672898
187GATA3_27048872_Chip-Seq_THYMUS_Human0.86450179
188RUNX_20019798_ChIP-Seq_JUKART_Human0.85565267
189VDR_24763502_ChIP-Seq_THP-1_Human0.84855067
190SMAD_19615063_ChIP-ChIP_OVARY_Human0.83790094
191ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82611611
192MYB_26560356_Chip-Seq_TH1_Human0.82445800
193VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82425644
194JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82038076
195HIF1A_21447827_ChIP-Seq_MCF-7_Human0.80927284
196SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80680313
197SPI1_23547873_ChIP-Seq_NB4_Human0.80095136
198PU_27001747_Chip-Seq_BMDM_Mouse0.79682684
199POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.77294155

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat5.65108711
2MP0010234_abnormal_vibrissa_follicle5.24185576
3MP0003787_abnormal_imprinting4.06008754
4MP0001348_abnormal_lacrimal_gland3.59478690
5MP0001835_abnormal_antigen_presentation3.58780229
6MP0009785_altered_susceptibility_to3.31974088
7MP0001346_abnormal_lacrimal_gland3.20751249
8MP0006292_abnormal_olfactory_placode3.19387169
9MP0000685_abnormal_immune_system3.12157449
10MP0002163_abnormal_gland_morphology3.03760331
11MP0003436_decreased_susceptibility_to2.90649248
12MP0002148_abnormal_hypersensitivity_rea2.81570795
13MP0002138_abnormal_hepatobiliary_system2.65741724
14MP0003646_muscle_fatigue2.64272265
15MP0008877_abnormal_DNA_methylation2.58098881
16MP0000569_abnormal_digit_pigmentation2.45353047
17MP0001968_abnormal_touch/_nociception2.32416658
18MP0003195_calcinosis2.24789361
19MP0002006_tumorigenesis2.20052944
20MP0006276_abnormal_autonomic_nervous2.16670420
21MP0004142_abnormal_muscle_tone2.16375221
22MP0005551_abnormal_eye_electrophysiolog2.15327294
23MP0000778_abnormal_nervous_system2.13484584
24MP0009046_muscle_twitch2.12908090
25MP0002166_altered_tumor_susceptibility2.10816159
26MP0009745_abnormal_behavioral_response2.10624313
27MP0003880_abnormal_central_pattern2.09992429
28MP0010678_abnormal_skin_adnexa2.09839258
29MP0005423_abnormal_somatic_nervous2.09137576
30MP0002837_dystrophic_cardiac_calcinosis2.08949126
31MP0003121_genomic_imprinting2.08115592
32MP0005310_abnormal_salivary_gland2.07247186
33MP0002653_abnormal_ependyma_morphology2.03746070
34MP0005000_abnormal_immune_tolerance2.00583085
35MP0005387_immune_system_phenotype2.00153464
36MP0001790_abnormal_immune_system2.00153464
37MP0005076_abnormal_cell_differentiation1.98563323
38MP0003136_yellow_coat_color1.96228220
39MP0002272_abnormal_nervous_system1.94575100
40MP0003635_abnormal_synaptic_transmissio1.93223075
41MP0005025_abnormal_response_to1.92539939
42MP0002009_preneoplasia1.90275410
43MP0004859_abnormal_synaptic_plasticity1.89126184
44MP0003453_abnormal_keratinocyte_physiol1.86654867
45MP0001486_abnormal_startle_reflex1.86212847
46MP0004947_skin_inflammation1.84695144
47MP0002736_abnormal_nociception_after1.83577741
48MP0002796_impaired_skin_barrier1.80821243
49MP0004510_myositis1.80527806
50MP0004885_abnormal_endolymph1.76288770
51MP0005671_abnormal_response_to1.72762599
52MP0002572_abnormal_emotion/affect_behav1.71919126
53MP0003122_maternal_imprinting1.71770435
54MP0002735_abnormal_chemical_nociception1.69824501
55MP0001485_abnormal_pinna_reflex1.68220959
56MP0010352_gastrointestinal_tract_polyps1.68131820
57MP0002063_abnormal_learning/memory/cond1.68018363
58MP0003566_abnormal_cell_adhesion1.64626218
59MP0001800_abnormal_humoral_immune1.63956403
60MP0004043_abnormal_pH_regulation1.63746134
61MP0003941_abnormal_skin_development1.63438324
62MP0002064_seizures1.62674661
63MP0006082_CNS_inflammation1.62536873
64MP0000955_abnormal_spinal_cord1.62138891
65MP0000537_abnormal_urethra_morphology1.61586410
66MP0002557_abnormal_social/conspecific_i1.60951991
67MP0002638_abnormal_pupillary_reflex1.60520135
68MP0002452_abnormal_antigen_presenting1.60376359
69MP0002102_abnormal_ear_morphology1.58859590
70MP0002067_abnormal_sensory_capabilities1.58140571
71MP0002733_abnormal_thermal_nociception1.58005095
72MP0001970_abnormal_pain_threshold1.57103189
73MP0003303_peritoneal_inflammation1.56107787
74MP0003890_abnormal_embryonic-extraembry1.55400372
75MP0003705_abnormal_hypodermis_morpholog1.51804106
76MP0001881_abnormal_mammary_gland1.51473418
77MP0002723_abnormal_immune_serum1.49966620
78MP0000627_abnormal_mammary_gland1.48123161
79MP0002184_abnormal_innervation1.48004157
80MP0004742_abnormal_vestibular_system1.47466105
81MP0000383_abnormal_hair_follicle1.46862778
82MP0003448_altered_tumor_morphology1.46188545
83MP0000631_abnormal_neuroendocrine_gland1.45959499
84MP0002419_abnormal_innate_immunity1.44587013
85MP0005646_abnormal_pituitary_gland1.43922350
86MP0005623_abnormal_meninges_morphology1.43431888
87MP0001501_abnormal_sleep_pattern1.43189175
88MP0002734_abnormal_mechanical_nocicepti1.41844740
89MP0010155_abnormal_intestine_physiology1.40289075
90MP0004145_abnormal_muscle_electrophysio1.32626464
91MP0004924_abnormal_behavior1.31489636
92MP0005386_behavior/neurological_phenoty1.31489636
93MP0005275_abnormal_skin_tensile1.31079091
94MP0004133_heterotaxia1.30073596
95MP0001216_abnormal_epidermal_layer1.29833805
96MP0001819_abnormal_immune_cell1.29809199
97MP0005083_abnormal_biliary_tract1.29371635
98MP0000427_abnormal_hair_cycle1.28642728
99MP0001984_abnormal_olfaction1.28290929
100MP0002752_abnormal_somatic_nervous1.28223732
101MP0005195_abnormal_posterior_eye1.27957565
102MP0002882_abnormal_neuron_morphology1.26081052
103MP0003091_abnormal_cell_migration1.24357389
104MP0005379_endocrine/exocrine_gland_phen1.24097677
105MP0008789_abnormal_olfactory_epithelium1.23691926
106MP0001440_abnormal_grooming_behavior1.23691749
107MP0001533_abnormal_skeleton_physiology1.22757310
108MP0003123_paternal_imprinting1.22606490
109MP0002420_abnormal_adaptive_immunity1.22216193
110MP0001188_hyperpigmentation1.21501776
111MP0008872_abnormal_physiological_respon1.20221027
112MP0001853_heart_inflammation1.14768686
113MP0009764_decreased_sensitivity_to1.13728625
114MP0001986_abnormal_taste_sensitivity1.12594536
115MP0005174_abnormal_tail_pigmentation1.11514158
116MP0002098_abnormal_vibrissa_morphology1.11355196
117MP0002876_abnormal_thyroid_physiology1.10966714
118MP0004264_abnormal_extraembryonic_tissu1.10754504
119MP0002928_abnormal_bile_duct1.09352933
120MP0000026_abnormal_inner_ear1.08968055
121MP0005394_taste/olfaction_phenotype1.08026115
122MP0005499_abnormal_olfactory_system1.08026115
123MP0000858_altered_metastatic_potential1.07901181
124MP0005377_hearing/vestibular/ear_phenot1.07304901
125MP0003878_abnormal_ear_physiology1.07304901
126MP0003879_abnormal_hair_cell1.07198532
127MP0004270_analgesia1.06817926
128MP0001845_abnormal_inflammatory_respons1.04884736
129MP0005084_abnormal_gallbladder_morpholo1.04856402
130MP0002152_abnormal_brain_morphology1.04684650
131MP0005645_abnormal_hypothalamus_physiol1.04333636
132MP0002095_abnormal_skin_pigmentation1.04181272
133MP0005397_hematopoietic_system_phenotyp1.03793426
134MP0001545_abnormal_hematopoietic_system1.03793426
135MP0002938_white_spotting1.03600432
136MP0009840_abnormal_foam_cell1.03140960
137MP0004808_abnormal_hematopoietic_stem1.02841631
138MP0001293_anophthalmia1.02713811
139MP0004272_abnormal_basement_membrane1.02480981
140MP0005501_abnormal_skin_physiology1.01981525
141MP0009333_abnormal_splenocyte_physiolog1.00423642
142MP0009278_abnormal_bone_marrow0.99525918
143MP0004130_abnormal_muscle_cell0.97973736
144MP0000716_abnormal_immune_system0.97551149
145MP0001963_abnormal_hearing_physiology0.96931901
146MP0005253_abnormal_eye_physiology0.96846398
147MP0006072_abnormal_retinal_apoptosis0.96405527
148MP0002229_neurodegeneration0.96087201
149MP0002277_abnormal_respiratory_mucosa0.95475290
150MP0001849_ear_inflammation0.94699442
151MP0000613_abnormal_salivary_gland0.94079775
152MP0008469_abnormal_protein_level0.93233425
153MP0000049_abnormal_middle_ear0.92833130
154MP0001324_abnormal_eye_pigmentation0.91697245
155MP0001905_abnormal_dopamine_level0.90954062
156MP0000015_abnormal_ear_pigmentation0.88768859
157MP0000377_abnormal_hair_follicle0.87891114
158MP0003936_abnormal_reproductive_system0.87355882
159MP0003633_abnormal_nervous_system0.86012610
160MP0002877_abnormal_melanocyte_morpholog0.85951307
161MP0003300_gastrointestinal_ulcer0.83418608
162MP0003861_abnormal_nervous_system0.82610658
163MP0002398_abnormal_bone_marrow0.82136981
164MP0002066_abnormal_motor_capabilities/c0.81493493
165MP0002060_abnormal_skin_morphology0.80792121
166MP0004147_increased_porphyrin_level0.80025479
167MP0003866_abnormal_defecation0.79994874
168MP0005248_abnormal_Harderian_gland0.79714563
169MP0002405_respiratory_system_inflammati0.77158301
170MP0009053_abnormal_anal_canal0.76378370
171MP0003045_fibrosis0.74828732
172MP0000230_abnormal_systemic_arterial0.72564977
173MP0001529_abnormal_vocalization0.72480490
174MP0004811_abnormal_neuron_physiology0.72072835
175MP0004019_abnormal_vitamin_homeostasis0.71732767
176MP0003937_abnormal_limbs/digits/tail_de0.70348081
177MP0008775_abnormal_heart_ventricle0.70224550
178MP0002429_abnormal_blood_cell0.69927050
179MP0003011_delayed_dark_adaptation0.69812594
180MP0005367_renal/urinary_system_phenotyp0.67444111
181MP0000516_abnormal_urinary_system0.67444111
182MP0010307_abnormal_tumor_latency0.67233321
183MP0008438_abnormal_cutaneous_collagen0.66909391
184MP0005390_skeleton_phenotype0.63801916
185MP0000733_abnormal_muscle_development0.61376786
186MP0000470_abnormal_stomach_morphology0.61122738
187MP0003075_altered_response_to0.60768800
188MP0002136_abnormal_kidney_physiology0.60131656
189MP0004782_abnormal_surfactant_physiolog0.58922530
190MP0010771_integument_phenotype0.58718418
191MP0000538_abnormal_urinary_bladder0.58253156
192MP0009931_abnormal_skin_appearance0.56668400
193MP0008057_abnormal_DNA_replication0.56411697
194MP0001915_intracranial_hemorrhage0.56180304
195MP0002722_abnormal_immune_system0.56065831

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal infarctions (HP:0005244)6.27316346
2Onycholysis (HP:0001806)5.51008638
3Increased IgM level (HP:0003496)4.70682356
4Pancreatic fibrosis (HP:0100732)4.41903742
5Milia (HP:0001056)4.37293083
6Pancreatic cysts (HP:0001737)4.31103782
7Hyperventilation (HP:0002883)4.29895998
8Molar tooth sign on MRI (HP:0002419)4.16475843
9Abnormality of midbrain morphology (HP:0002418)4.16475843
10Atrophic scars (HP:0001075)4.10836342
11Amelogenesis imperfecta (HP:0000705)3.97623813
12True hermaphroditism (HP:0010459)3.96489553
13Chronic otitis media (HP:0000389)3.86471163
14Nephronophthisis (HP:0000090)3.85269723
15Pili torti (HP:0003777)3.65382483
16Eczematoid dermatitis (HP:0000976)3.64388115
17Genetic anticipation (HP:0003743)3.59498795
18Fragile nails (HP:0001808)3.49754189
19Nasal polyposis (HP:0100582)3.49258338
20Optic neuritis (HP:0100653)3.42935674
21Retrobulbar optic neuritis (HP:0100654)3.42935674
22Osteolytic defects of the phalanges of the hand (HP:0009771)3.41625493
23Osteolytic defects of the hand bones (HP:0009699)3.41625493
24Abnormality of the renal medulla (HP:0100957)3.39347908
25Progressive cerebellar ataxia (HP:0002073)3.38948103
26Autoimmune thrombocytopenia (HP:0001973)3.38087308
27Medial flaring of the eyebrow (HP:0010747)3.37423041
28Orchitis (HP:0100796)3.37087476
29Congenital stationary night blindness (HP:0007642)3.33339002
30Protruding tongue (HP:0010808)3.25362774
31Recurrent bacterial skin infections (HP:0005406)3.24308955
32Alopecia of scalp (HP:0002293)3.19879725
33Plantar hyperkeratosis (HP:0007556)3.19798152
34Gait imbalance (HP:0002141)3.08786391
35Cystic liver disease (HP:0006706)3.05162083
36Pustule (HP:0200039)3.04393311
37Myositis (HP:0100614)2.99562168
38Peritonitis (HP:0002586)2.98373896
39Broad-based gait (HP:0002136)2.96747505
40Chronic hepatic failure (HP:0100626)2.94691681
41Abnormality of the renal cortex (HP:0011035)2.92564923
42Abnormality of macrophages (HP:0004311)2.91865975
43Drooling (HP:0002307)2.90494253
44Abnormality of proline metabolism (HP:0010907)2.87692123
45Hydroxyprolinuria (HP:0003080)2.87692123
46Rectal prolapse (HP:0002035)2.86047857
47Aplasia/Hypoplasia of the tibia (HP:0005772)2.85154224
48Abnormality of the nasal mucosa (HP:0000433)2.84543383
49Porencephaly (HP:0002132)2.83851542
50Focal seizures (HP:0007359)2.83238282
51Anorexia (HP:0002039)2.82799498
52Gaze-evoked nystagmus (HP:0000640)2.80781586
53Arterial thrombosis (HP:0004420)2.80663673
54Congenital primary aphakia (HP:0007707)2.79351774
55Vasculitis (HP:0002633)2.78206728
56Right ventricular cardiomyopathy (HP:0011663)2.73189508
57Esophageal varix (HP:0002040)2.71894153
58Febrile seizures (HP:0002373)2.71486776
59Hypergammaglobulinemia (HP:0010702)2.70416098
60Nephrogenic diabetes insipidus (HP:0009806)2.70347270
61Tetraparesis (HP:0002273)2.68917050
62Micronodular cirrhosis (HP:0001413)2.65935093
63Excessive salivation (HP:0003781)2.63930478
64Oligodactyly (hands) (HP:0001180)2.63448521
65Autoimmune hemolytic anemia (HP:0001890)2.58613718
66Mediastinal lymphadenopathy (HP:0100721)2.56497660
67Sclerocornea (HP:0000647)2.55653274
68Recurrent abscess formation (HP:0002722)2.53950563
69Thrombocytosis (HP:0001894)2.53681247
70Radial bowing (HP:0002986)2.51434295
71Patellar aplasia (HP:0006443)2.49575285
72Hepatoblastoma (HP:0002884)2.47949558
73Genital tract atresia (HP:0001827)2.47760274
74Amaurosis fugax (HP:0100576)2.47634191
75Focal motor seizures (HP:0011153)2.46837507
76Tubular atrophy (HP:0000092)2.46384250
77Aplasia/Hypoplasia of the tongue (HP:0010295)2.45302708
78Abolished electroretinogram (ERG) (HP:0000550)2.44719391
79Anencephaly (HP:0002323)2.44521616
80Ulnar bowing (HP:0003031)2.42780321
81Type II lissencephaly (HP:0007260)2.42511912
82Elevated erythrocyte sedimentation rate (HP:0003565)2.40828150
83Vaginal atresia (HP:0000148)2.40091595
84Poor coordination (HP:0002370)2.39248998
85Myocardial infarction (HP:0001658)2.36687909
86Premature loss of primary teeth (HP:0006323)2.35847109
87Abnormality of cochlea (HP:0000375)2.35279682
88Recurrent fungal infections (HP:0002841)2.34915494
89Vertebral compression fractures (HP:0002953)2.34626307
90Abnormal rod and cone electroretinograms (HP:0008323)2.34622431
91Aplasia/Hypoplasia of the patella (HP:0006498)2.33852748
92Prostate neoplasm (HP:0100787)2.33334359
93Congenital hepatic fibrosis (HP:0002612)2.32097813
94Periodontitis (HP:0000704)2.31961840
95Keratoconjunctivitis sicca (HP:0001097)2.25539099
96Postaxial foot polydactyly (HP:0001830)2.25437951
97Dialeptic seizures (HP:0011146)2.24930605
98Epileptic encephalopathy (HP:0200134)2.24385001
99Stenosis of the external auditory canal (HP:0000402)2.23922375
100Lissencephaly (HP:0001339)2.23051089
101Congenital sensorineural hearing impairment (HP:0008527)2.23041138
102Hematochezia (HP:0002573)2.20874856
103Abnormality of the labia minora (HP:0012880)2.20074862
104Gingival bleeding (HP:0000225)2.19771324
105Woolly hair (HP:0002224)2.19209186
106Fatigue (HP:0012378)2.17643899
107Abnormal drinking behavior (HP:0030082)2.17606799
108Polydipsia (HP:0001959)2.17606799
109Interstitial pulmonary disease (HP:0006530)2.17465249
110Hypochromic anemia (HP:0001931)2.17398495
111Abnormal hair laboratory examination (HP:0003328)2.16492301
112Absent speech (HP:0001344)2.16139707
113Recurrent gram-negative bacterial infections (HP:0005420)2.15455340
114Pachygyria (HP:0001302)2.13286199
115Optic nerve hypoplasia (HP:0000609)2.13190814
116Cleft eyelid (HP:0000625)2.12238711
117Polyphagia (HP:0002591)2.11823721
118Neoplasm of the adrenal cortex (HP:0100641)2.09832232
119Bowing of the arm (HP:0006488)2.09274400
120Bowed forearm bones (HP:0003956)2.09274400
121Attenuation of retinal blood vessels (HP:0007843)2.07882085
122Hyperparathyroidism (HP:0000843)2.07812099
123Thick nail (HP:0001805)2.07381909
124Concave nail (HP:0001598)2.06987044
125Chest pain (HP:0100749)2.06713046
126Skin ulcer (HP:0200042)2.06288649
127Premature rupture of membranes (HP:0001788)2.06060742
128Preaxial hand polydactyly (HP:0001177)2.05802402
129Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05753238
130Anhidrosis (HP:0000970)2.04990645
131Volvulus (HP:0002580)2.04222326
132Basal ganglia calcification (HP:0002135)2.02431093
133Short foot (HP:0001773)2.02323243
134Keratoconjunctivitis (HP:0001096)2.02030431
135Congenital, generalized hypertrichosis (HP:0004540)2.02006572
136Hypoplasia of dental enamel (HP:0006297)2.01835999
137Male pseudohermaphroditism (HP:0000037)2.01310480
138Myokymia (HP:0002411)2.01096029
139Narrow forehead (HP:0000341)2.00814089
140Nail dystrophy (HP:0008404)1.99077087
141Petechiae (HP:0000967)1.98990612
142Vertigo (HP:0002321)1.98927515
143Absence seizures (HP:0002121)1.98042218
144Cerebellar dysplasia (HP:0007033)1.97901708
145Dynein arm defect of respiratory motile cilia (HP:0012255)1.97187155
146Absent/shortened dynein arms (HP:0200106)1.97187155
147Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97128810
148Agitation (HP:0000713)1.96906898
149Lip pit (HP:0100267)1.96567239
150Stomach cancer (HP:0012126)1.95927724
151Inability to walk (HP:0002540)1.95747425
152Decreased central vision (HP:0007663)1.95400697
153Rib fusion (HP:0000902)1.94677675
154Postaxial hand polydactyly (HP:0001162)1.94323915
155Anophthalmia (HP:0000528)1.93664479
156Septo-optic dysplasia (HP:0100842)1.93639736
157Shawl scrotum (HP:0000049)1.92678637
158Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91917281
159Clumsiness (HP:0002312)1.90984768
160Highly arched eyebrow (HP:0002553)1.90913699
161Abnormal pancreas size (HP:0012094)1.90681836
162Hip dysplasia (HP:0001385)1.89376795
163Curly hair (HP:0002212)1.89155208
164Bony spicule pigmentary retinopathy (HP:0007737)1.89151067
165Polycythemia (HP:0001901)1.88971529
166Subacute progressive viral hepatitis (HP:0006572)1.88605205
167Polygenic inheritance (HP:0010982)1.87940398
168Abnormality of nail color (HP:0100643)1.87752317
169Gangrene (HP:0100758)1.87580328
170Thyroid-stimulating hormone excess (HP:0002925)1.87245283
171Atonic seizures (HP:0010819)1.86810868
172Purpura (HP:0000979)1.86168140
173Abnormality of the distal phalanges of the toes (HP:0010182)1.86131536
174Ectopic kidney (HP:0000086)1.85949487
175Abnormality of the fingertips (HP:0001211)1.85845149
176Abnormality of the gastric mucosa (HP:0004295)1.84706162
177Hemiparesis (HP:0001269)1.84656283
178Abnormality of DNA repair (HP:0003254)1.84071203
179Dandy-Walker malformation (HP:0001305)1.83943296
180Abnormality of glutamine family amino acid metabolism (HP:0010902)1.83708553
181Cellulitis (HP:0100658)1.83349868
182Palmar hyperkeratosis (HP:0010765)1.82986746
183Urticaria (HP:0001025)1.81566303
184Chronic sinusitis (HP:0011109)1.81470505
185Broad foot (HP:0001769)1.80894288
186Palmoplantar hyperkeratosis (HP:0000972)1.80644322
187Colon cancer (HP:0003003)1.80315138
188Pendular nystagmus (HP:0012043)1.80168152
189Nephritis (HP:0000123)1.79860328
190Oligodactyly (HP:0012165)1.79626012
191Decreased circulating renin level (HP:0003351)1.79417554
192Recurrent bronchitis (HP:0002837)1.79359957
193Specific learning disability (HP:0001328)1.78299756
194Polyuria (HP:0000103)1.77656756
195Retinal dysplasia (HP:0007973)1.77300655
196Enlarged kidneys (HP:0000105)1.76992901
197Abnormal ciliary motility (HP:0012262)1.76056917
198Preaxial foot polydactyly (HP:0001841)1.75964971
199Growth hormone deficiency (HP:0000824)1.75156237
200Renal cortical cysts (HP:0000803)1.73694670

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.77894656
2MAP3K144.97825461
3MST44.03907291
4CASK3.83629638
5TYK23.64650126
6IKBKB3.23890124
7TBK13.20315875
8IKBKE2.79553939
9FRK2.71320329
10BMPR1B2.70951070
11JAK32.66372920
12CHUK2.65452385
13TNIK2.37900030
14WNK42.25141849
15MAPK132.24959496
16MAP3K132.23504643
17WNK32.16319354
18TESK12.13948567
19MARK12.12226545
20ACVR1B2.06356428
21EPHB12.05708272
22NTRK21.98528164
23MST1R1.96372430
24TAOK31.94468763
25NTRK31.93225585
26ADRBK21.89882028
27PINK11.82414709
28BCR1.80080732
29MAP3K41.75722885
30PTK61.72612210
31STK391.72305740
32GRK11.70433663
33EPHB21.69703357
34JAK11.65259656
35PIM21.64673645
36FER1.62795504
37RPS6KB21.60155774
38FGFR41.59766454
39EPHA31.59686881
40EPHA41.56470741
41PNCK1.45397275
42DYRK21.42621098
43SIK21.38343985
44CAMK1G1.36329106
45MKNK21.35445385
46INSRR1.32605123
47OXSR11.28909167
48MAP3K101.26882450
49MAP2K71.25747922
50LRRK21.24661543
51PRKCG1.22959952
52BMX1.17644720
53MAP3K91.17532315
54PBK1.16477861
55PKN21.14843513
56LMTK21.14689444
57IRAK41.14677620
58CAMK1D1.14380244
59BMPR21.13776546
60STK111.11671089
61PIK3CA1.11357360
62BLK1.09909006
63ADRBK11.09471286
64ZAK1.08568954
65STK31.04815713
66STK161.01828034
67FGFR31.01197405
68ABL20.99623023
69MAP4K20.95887412
70PAK40.95762641
71SGK20.93394569
72SGK2230.92431038
73SGK4940.92431038
74MET0.92325429
75TYRO30.91998553
76RPS6KA40.89720841
77PIM10.88386123
78AKT30.88225280
79PTK20.87060663
80CAMK10.86163529
81JAK20.82635084
82STK100.82493770
83DMPK0.82394490
84LATS10.81989041
85PLK20.80676725
86TXK0.79250355
87TEC0.78966979
88ARAF0.78174088
89EIF2AK20.77802481
90PRKCE0.76928089
91FGFR20.75029899
92PKN10.72834992
93MAP2K20.71840946
94STK40.71236533
95SGK10.70914000
96SIK10.70138002
97PRKCH0.69791142
98DAPK20.69476431
99RIPK40.69365986
100CDK190.69126514
101PTK2B0.68828511
102CDK60.68721260
103WNK10.67723030
104LIMK10.67470379
105MINK10.66727067
106MAP3K80.65982720
107CAMK2A0.64403125
108TRPM70.64342915
109ERBB30.62699108
110RIPK10.61811025
111MARK20.61386162
112TGFBR10.60236045
113PAK30.59372889
114ERN10.58635511
115RPS6KA10.57917715
116ERBB20.57530237
117STK240.57033341
118TTN0.56784750
119MAPKAPK20.56472902
120ZAP700.56075439
121PRKCZ0.55253948
122NEK90.54586164
123CSNK1G20.54356106
124DYRK1A0.53926385
125TRIB30.53529382
126CDC70.51977276
127SIK30.50933808
128PRKACA0.50652227
129KSR20.50635837
130PRKCQ0.50205857
131FLT30.49704795
132CAMK40.49659942
133CSNK1A10.48902833
134ABL10.47568831
135CDK50.47511821
136MAPKAPK30.47316989
137CAMKK20.47297328
138MAP2K40.46872556
139DDR20.46771803
140EGFR0.45388842
141DYRK1B0.45261475
142CSNK1E0.45173043
143CDK30.45142964
144RET0.44702696
145TLK10.44422330
146IRAK30.44082964
147RPS6KA30.43549279
148PRKD30.42853898
149TIE10.42587365
150PLK40.42228740
151NEK20.41632905
152PAK10.41286732
153PHKG10.41203780
154PHKG20.41203780
155PRKG10.40887235
156MAP3K20.40734126
157ALK0.40277361
158CSNK1A1L0.39948340
159PRKCD0.39487883
160CSNK1D0.39237921
161SGK30.39120173
162NUAK10.39033809
163NME10.39002462
164PRKAA20.37301671
165PRKAA10.36905844
166RPS6KA50.36814514
167CSNK1G10.36682855
168CSK0.35637914
169TRIM280.34897054
170MAP2K60.34842800
171MAP2K10.34613976
172MAP3K70.33904408
173CAMKK10.33677399
174PRKCA0.33132248
175MAP3K30.32720202
176OBSCN0.31792949
177LCK0.31571249
178SRC0.28582935
179DAPK30.27499623
180ERBB40.26537591
181MARK30.24895373
182MAP3K10.24572346
183GSK3A0.22609943
184PDGFRA0.22421106
185TSSK60.22379475
186PDGFRB0.22008631
187SCYL20.21394630
188NLK0.21289399
189RPS6KA60.20895795

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.62936457
2Nicotine addiction_Homo sapiens_hsa050333.57521796
3Graft-versus-host disease_Homo sapiens_hsa053323.38292454
4Type I diabetes mellitus_Homo sapiens_hsa049402.63945842
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.61391096
6Leishmaniasis_Homo sapiens_hsa051402.59065713
7Phototransduction_Homo sapiens_hsa047442.51930077
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.45788037
9Autoimmune thyroid disease_Homo sapiens_hsa053202.45611168
10Toxoplasmosis_Homo sapiens_hsa051452.37405583
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.31739496
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.30293238
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.29642594
14Legionellosis_Homo sapiens_hsa051342.26184048
15TNF signaling pathway_Homo sapiens_hsa046682.24195248
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.23667495
17NF-kappa B signaling pathway_Homo sapiens_hsa040642.14748336
18Morphine addiction_Homo sapiens_hsa050322.14633732
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.11210531
20Glutamatergic synapse_Homo sapiens_hsa047242.03412828
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02931542
22Measles_Homo sapiens_hsa051622.00854877
23Circadian entrainment_Homo sapiens_hsa047131.99730408
24Butanoate metabolism_Homo sapiens_hsa006501.98931285
25Viral myocarditis_Homo sapiens_hsa054161.98673926
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.98501019
27Pertussis_Homo sapiens_hsa051331.96866816
28Insulin secretion_Homo sapiens_hsa049111.95396212
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.95112748
30Influenza A_Homo sapiens_hsa051641.94159846
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.91356861
32GABAergic synapse_Homo sapiens_hsa047271.85965914
33Taste transduction_Homo sapiens_hsa047421.80590087
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71616572
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.66287942
36African trypanosomiasis_Homo sapiens_hsa051431.59557458
37Herpes simplex infection_Homo sapiens_hsa051681.59054990
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.58924043
39Small cell lung cancer_Homo sapiens_hsa052221.57992026
40Homologous recombination_Homo sapiens_hsa034401.55243051
41Antigen processing and presentation_Homo sapiens_hsa046121.55159321
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53963491
43Shigellosis_Homo sapiens_hsa051311.53930849
44Apoptosis_Homo sapiens_hsa042101.53356350
45Serotonergic synapse_Homo sapiens_hsa047261.52812018
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.52799780
47Cardiac muscle contraction_Homo sapiens_hsa042601.50569036
48Dopaminergic synapse_Homo sapiens_hsa047281.48935718
49Dorso-ventral axis formation_Homo sapiens_hsa043201.48052896
50Osteoclast differentiation_Homo sapiens_hsa043801.43920297
51Staphylococcus aureus infection_Homo sapiens_hsa051501.43315263
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43298558
53Caffeine metabolism_Homo sapiens_hsa002321.41873912
54Tryptophan metabolism_Homo sapiens_hsa003801.41759769
55Olfactory transduction_Homo sapiens_hsa047401.41715319
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.37877581
57Malaria_Homo sapiens_hsa051441.36782944
58Rheumatoid arthritis_Homo sapiens_hsa053231.35814190
59Cholinergic synapse_Homo sapiens_hsa047251.35801868
60Salivary secretion_Homo sapiens_hsa049701.34680998
61Nitrogen metabolism_Homo sapiens_hsa009101.32108370
62Ether lipid metabolism_Homo sapiens_hsa005651.27708176
63Axon guidance_Homo sapiens_hsa043601.26850131
64Amoebiasis_Homo sapiens_hsa051461.24459520
65Chemokine signaling pathway_Homo sapiens_hsa040621.23849435
66Oxytocin signaling pathway_Homo sapiens_hsa049211.22439523
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.21487491
68Hepatitis C_Homo sapiens_hsa051601.18359246
69Fanconi anemia pathway_Homo sapiens_hsa034601.17766499
70ABC transporters_Homo sapiens_hsa020101.17185658
71Long-term depression_Homo sapiens_hsa047301.15333080
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15066814
73Leukocyte transendothelial migration_Homo sapiens_hsa046701.15023345
74Tuberculosis_Homo sapiens_hsa051521.13895534
75Gastric acid secretion_Homo sapiens_hsa049711.12153543
76Cocaine addiction_Homo sapiens_hsa050301.10315602
77Calcium signaling pathway_Homo sapiens_hsa040201.10085759
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08546322
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07182440
80cAMP signaling pathway_Homo sapiens_hsa040241.06919378
81Salmonella infection_Homo sapiens_hsa051321.05686074
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04746189
83Retinol metabolism_Homo sapiens_hsa008300.99672120
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.99629976
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98927213
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.98689003
87p53 signaling pathway_Homo sapiens_hsa041150.98612810
88Propanoate metabolism_Homo sapiens_hsa006400.97441490
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95500160
90Adherens junction_Homo sapiens_hsa045200.93197900
91Mineral absorption_Homo sapiens_hsa049780.92860407
92Ovarian steroidogenesis_Homo sapiens_hsa049130.92625240
93Amphetamine addiction_Homo sapiens_hsa050310.92552227
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92548508
95Prolactin signaling pathway_Homo sapiens_hsa049170.91435544
96Chemical carcinogenesis_Homo sapiens_hsa052040.91154286
97Proteoglycans in cancer_Homo sapiens_hsa052050.90289249
98Basal cell carcinoma_Homo sapiens_hsa052170.90160263
99Basal transcription factors_Homo sapiens_hsa030220.90143978
100Hepatitis B_Homo sapiens_hsa051610.90060282
101Chronic myeloid leukemia_Homo sapiens_hsa052200.89049429
102Lysine degradation_Homo sapiens_hsa003100.88971408
103Renin secretion_Homo sapiens_hsa049240.88961864
104Asthma_Homo sapiens_hsa053100.88458143
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88132805
106Glycerolipid metabolism_Homo sapiens_hsa005610.87872163
107Regulation of autophagy_Homo sapiens_hsa041400.86238250
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85492162
109ECM-receptor interaction_Homo sapiens_hsa045120.82405846
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82129775
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81310994
112B cell receptor signaling pathway_Homo sapiens_hsa046620.79089971
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77999350
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77391162
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75466710
116beta-Alanine metabolism_Homo sapiens_hsa004100.75384631
117Viral carcinogenesis_Homo sapiens_hsa052030.74143471
118Peroxisome_Homo sapiens_hsa041460.72891706
119Histidine metabolism_Homo sapiens_hsa003400.71869951
120Epstein-Barr virus infection_Homo sapiens_hsa051690.70179798
121Linoleic acid metabolism_Homo sapiens_hsa005910.68328167
122Pancreatic secretion_Homo sapiens_hsa049720.68178079
123MicroRNAs in cancer_Homo sapiens_hsa052060.68116205
124Selenocompound metabolism_Homo sapiens_hsa004500.67945819
125Renin-angiotensin system_Homo sapiens_hsa046140.67673031
126Hematopoietic cell lineage_Homo sapiens_hsa046400.67340036
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.65944189
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62251122
129Focal adhesion_Homo sapiens_hsa045100.61854998
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61418944
131Tight junction_Homo sapiens_hsa045300.60765811
132HTLV-I infection_Homo sapiens_hsa051660.60325220
133Oxidative phosphorylation_Homo sapiens_hsa001900.60026186
134Ras signaling pathway_Homo sapiens_hsa040140.59226771
135Proteasome_Homo sapiens_hsa030500.58474999
136Fatty acid biosynthesis_Homo sapiens_hsa000610.57466945
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57248256
138MAPK signaling pathway_Homo sapiens_hsa040100.57219870
139Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56363882
140Bile secretion_Homo sapiens_hsa049760.54922582
141Dilated cardiomyopathy_Homo sapiens_hsa054140.54537898
142Arachidonic acid metabolism_Homo sapiens_hsa005900.54394648
143RNA degradation_Homo sapiens_hsa030180.54133122
144Synaptic vesicle cycle_Homo sapiens_hsa047210.52357613
145Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52054756
146cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51899599
147T cell receptor signaling pathway_Homo sapiens_hsa046600.51155267
148Pancreatic cancer_Homo sapiens_hsa052120.51070087
149Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50635144
150Pathways in cancer_Homo sapiens_hsa052000.49994057
151Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49921403
152Maturity onset diabetes of the young_Homo sapiens_hsa049500.49106688
153Hippo signaling pathway_Homo sapiens_hsa043900.49100723
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.48920018
155Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47600980
156Sulfur relay system_Homo sapiens_hsa041220.47421116
157Prostate cancer_Homo sapiens_hsa052150.47076083
158Steroid biosynthesis_Homo sapiens_hsa001000.46987307
159Acute myeloid leukemia_Homo sapiens_hsa052210.45515515
160Huntingtons disease_Homo sapiens_hsa050160.44907479
161Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44342619
162Bladder cancer_Homo sapiens_hsa052190.42755676
163HIF-1 signaling pathway_Homo sapiens_hsa040660.42084188
164Type II diabetes mellitus_Homo sapiens_hsa049300.42062384
165Thyroid hormone synthesis_Homo sapiens_hsa049180.41193372
166Prion diseases_Homo sapiens_hsa050200.39967839
167Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39727577
168Long-term potentiation_Homo sapiens_hsa047200.39440828
169Melanogenesis_Homo sapiens_hsa049160.37475081
170Ribosome_Homo sapiens_hsa030100.37397362
171Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37382369
172Wnt signaling pathway_Homo sapiens_hsa043100.36439057
173Fatty acid degradation_Homo sapiens_hsa000710.35276784
174Phagosome_Homo sapiens_hsa041450.34013085
175Lysosome_Homo sapiens_hsa041420.32580612
176Endometrial cancer_Homo sapiens_hsa052130.31814960
177Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31676649
178VEGF signaling pathway_Homo sapiens_hsa043700.31447900
179Notch signaling pathway_Homo sapiens_hsa043300.30009467
180Primary immunodeficiency_Homo sapiens_hsa053400.28544640
181Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27494925
182Platelet activation_Homo sapiens_hsa046110.26975623
183Renal cell carcinoma_Homo sapiens_hsa052110.26883293
184Neurotrophin signaling pathway_Homo sapiens_hsa047220.26638510
185FoxO signaling pathway_Homo sapiens_hsa040680.26586847
186mTOR signaling pathway_Homo sapiens_hsa041500.25261119
187Phenylalanine metabolism_Homo sapiens_hsa003600.24214004
188Hedgehog signaling pathway_Homo sapiens_hsa043400.24142992
189Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22681728

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