MACC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.39429398
2hemidesmosome assembly (GO:0031581)8.43947424
3behavioral response to nicotine (GO:0035095)7.70530574
4regulation of water loss via skin (GO:0033561)6.87219800
5interferon-gamma secretion (GO:0072643)6.79453862
6establishment of skin barrier (GO:0061436)6.47029891
7bundle of His cell to Purkinje myocyte communication (GO:0086069)5.90331980
8multicellular organismal water homeostasis (GO:0050891)5.05799326
9keratinocyte differentiation (GO:0030216)5.05282862
10keratinization (GO:0031424)4.86879137
11skin morphogenesis (GO:0043589)4.81812143
12tachykinin receptor signaling pathway (GO:0007217)4.61725064
13intestinal epithelial cell development (GO:0060576)4.54842794
14molting cycle (GO:0042303)4.50018205
15hair cycle (GO:0042633)4.50018205
16keratinocyte proliferation (GO:0043616)4.49409348
17surfactant homeostasis (GO:0043129)4.40602199
18water homeostasis (GO:0030104)4.22588767
19L-fucose catabolic process (GO:0042355)4.13618783
20fucose catabolic process (GO:0019317)4.13618783
21L-fucose metabolic process (GO:0042354)4.13618783
22water-soluble vitamin biosynthetic process (GO:0042364)4.08149398
23ectoderm development (GO:0007398)4.07398093
24wound healing, spreading of epidermal cells (GO:0035313)4.00209907
25chemical homeostasis within a tissue (GO:0048875)3.93766957
26positive regulation of digestive system process (GO:0060456)3.92215566
27lung lobe morphogenesis (GO:0060463)3.90712146
28epidermal cell differentiation (GO:0009913)3.88372882
29response to xenobiotic stimulus (GO:0009410)3.83249142
30mesodermal cell differentiation (GO:0048333)3.80643004
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.77119348
32sphingoid metabolic process (GO:0046519)3.76809079
33epithelial cell differentiation involved in prostate gland development (GO:0060742)3.75633876
34positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.71944144
35hepatocyte apoptotic process (GO:0097284)3.65093602
36branching involved in salivary gland morphogenesis (GO:0060445)3.56908089
37regulation of chemokine secretion (GO:0090196)3.55661959
38positive regulation of protein homooligomerization (GO:0032464)3.53837406
39membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.50732352
40intermediate filament organization (GO:0045109)3.50584427
41regulation of T cell tolerance induction (GO:0002664)3.50256356
42sphingosine metabolic process (GO:0006670)3.49577244
43cellular response to exogenous dsRNA (GO:0071360)3.48960869
44regulation of glomerular filtration (GO:0003093)3.45251349
45negative regulation of keratinocyte proliferation (GO:0010839)3.44607177
46membrane repolarization during action potential (GO:0086011)3.40798920
47epidermis development (GO:0008544)3.40526165
48pattern specification involved in kidney development (GO:0061004)3.39408824
49epithelial cell-cell adhesion (GO:0090136)3.39038032
50DNA deamination (GO:0045006)3.38148405
51indolalkylamine metabolic process (GO:0006586)3.37941269
52parturition (GO:0007567)3.37320080
53regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.36661138
54endoderm formation (GO:0001706)3.33681865
55cellular response to interferon-alpha (GO:0035457)3.33465624
56negative regulation of cell fate specification (GO:0009996)3.32037074
57diol metabolic process (GO:0034311)3.31550815
58magnesium ion transport (GO:0015693)3.30543574
59cell adhesion mediated by integrin (GO:0033627)3.28936098
60cell-substrate junction assembly (GO:0007044)3.28742560
61regulation of interleukin-8 secretion (GO:2000482)3.23995114
62cell proliferation in forebrain (GO:0021846)3.23335498
63regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.22063081
64tight junction assembly (GO:0070830)3.21085778
65sulfation (GO:0051923)3.18835255
66adaptation of signaling pathway (GO:0023058)3.16563182
67regulation of phospholipase A2 activity (GO:0032429)3.16070025
68negative regulation of T cell differentiation in thymus (GO:0033085)3.14259215
69peptide cross-linking (GO:0018149)3.13987707
70negative regulation of systemic arterial blood pressure (GO:0003085)3.08685047
71positive regulation of glomerulus development (GO:0090193)3.08287886
72detection of light stimulus involved in visual perception (GO:0050908)3.08141051
73detection of light stimulus involved in sensory perception (GO:0050962)3.08141051
74epithelial cilium movement (GO:0003351)3.06010421
75glomerular visceral epithelial cell development (GO:0072015)3.05455547
76regulation of cell proliferation involved in kidney development (GO:1901722)3.05300896
77regulation of glomerulus development (GO:0090192)3.05207391
78dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.03969256
79response to pheromone (GO:0019236)3.03456654
80cornea development in camera-type eye (GO:0061303)3.02671906
81serotonin metabolic process (GO:0042428)3.02288441
82regulation of ruffle assembly (GO:1900027)3.00549363
83axoneme assembly (GO:0035082)3.00356402
84kidney morphogenesis (GO:0060993)2.99757319
85negative regulation of transcription regulatory region DNA binding (GO:2000678)2.99546544
86regulation of posttranscriptional gene silencing (GO:0060147)2.96328350
87regulation of gene silencing by miRNA (GO:0060964)2.96328350
88regulation of gene silencing by RNA (GO:0060966)2.96328350
89mammary gland epithelial cell differentiation (GO:0060644)2.94900128
90keratinocyte development (GO:0003334)2.94248229
91wound healing, spreading of cells (GO:0044319)2.92259235
92gland morphogenesis (GO:0022612)2.92033212
93regulation of interleukin-12 biosynthetic process (GO:0045075)2.90275850
94rRNA catabolic process (GO:0016075)2.90178703
95lung-associated mesenchyme development (GO:0060484)2.89866746
96axonemal dynein complex assembly (GO:0070286)2.88856237
97thyroid hormone metabolic process (GO:0042403)2.88366178
98viral transcription (GO:0019083)2.88031552
99atrioventricular valve morphogenesis (GO:0003181)2.88013502
100regulation of tolerance induction (GO:0002643)2.86921511
101regulation of cell fate specification (GO:0042659)2.86714325
102lung vasculature development (GO:0060426)2.86498735
103primary amino compound metabolic process (GO:1901160)2.86151733
104regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.85046684
105cilium movement (GO:0003341)2.84445710
106renal system process involved in regulation of blood volume (GO:0001977)2.83674383
107negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.82032730
108protein polyglutamylation (GO:0018095)2.81693457
109auditory receptor cell differentiation (GO:0042491)2.81025650
110hypotonic response (GO:0006971)2.80486640
111glomerular epithelial cell development (GO:0072310)2.80082885
112regulation of germinal center formation (GO:0002634)2.79921247
113cellular response to ATP (GO:0071318)2.77579486
114somite development (GO:0061053)2.77243369
115positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.76907787
116positive regulation of fatty acid transport (GO:2000193)2.75468724
117respiratory tube development (GO:0030323)2.74824646
118translational termination (GO:0006415)2.74467948
119regulation of hippo signaling (GO:0035330)2.73519170
120kynurenine metabolic process (GO:0070189)2.73247596
121cochlea development (GO:0090102)2.72960299
122flavonoid metabolic process (GO:0009812)2.72867036
123tryptophan catabolic process (GO:0006569)2.72556533
124indole-containing compound catabolic process (GO:0042436)2.72556533
125indolalkylamine catabolic process (GO:0046218)2.72556533
126epithelial structure maintenance (GO:0010669)2.72016083
127hippo signaling (GO:0035329)2.71836084
128DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.70303613
129embryonic epithelial tube formation (GO:0001838)2.69987980
130preassembly of GPI anchor in ER membrane (GO:0016254)2.69950093
131establishment of protein localization to Golgi (GO:0072600)2.69587374
132maintenance of gastrointestinal epithelium (GO:0030277)2.69036954
133negative regulation of metanephros development (GO:0072217)2.67073972
134cytoskeletal anchoring at plasma membrane (GO:0007016)2.65689079
135regulation of rhodopsin mediated signaling pathway (GO:0022400)2.64969183
136positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.63483290
137transepithelial transport (GO:0070633)2.61135472
138indole-containing compound metabolic process (GO:0042430)2.60796012
139membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.60059113
140negative regulation of cell fate commitment (GO:0010454)2.60024860
141cilium or flagellum-dependent cell motility (GO:0001539)2.59219607
142positive regulation of organelle assembly (GO:1902117)2.59032662
143regulation of natural killer cell differentiation (GO:0032823)2.58777009
144establishment of protein localization to mitochondrial membrane (GO:0090151)2.58403284
145positive regulation of icosanoid secretion (GO:0032305)2.58086440
146rhodopsin mediated signaling pathway (GO:0016056)2.58063623
147response to histamine (GO:0034776)2.57061779
148regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.56854769
149cellular response to nicotine (GO:0071316)2.56649361
150spinal cord motor neuron differentiation (GO:0021522)2.55547011
151ribosomal small subunit biogenesis (GO:0042274)2.55324934
152antigen processing and presentation of endogenous antigen (GO:0019883)2.55115803
153substrate-dependent cell migration (GO:0006929)2.55001673
154nephron tubule formation (GO:0072079)2.54822833
155regulation of transforming growth factor beta1 production (GO:0032908)2.53706337
156synaptic transmission, cholinergic (GO:0007271)2.53671580
157RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.53468444
158positive regulation of actin filament depolymerization (GO:0030836)2.53227048
159epithelial tube formation (GO:0072175)2.51787724
160dentate gyrus development (GO:0021542)2.50199341
161regulation of cardioblast differentiation (GO:0051890)2.50062673
162regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.49629414
163regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.49539448
164protein complex biogenesis (GO:0070271)2.49135737
165detection of bacterium (GO:0016045)2.48750897
166regulation of cilium movement (GO:0003352)2.47935532
167positive regulation of fatty acid oxidation (GO:0046321)2.47837451
168DNA methylation involved in gamete generation (GO:0043046)2.47824045
169regulation of mesoderm development (GO:2000380)2.47618386
170protein localization to Golgi apparatus (GO:0034067)2.47275070
171hepatocyte differentiation (GO:0070365)2.45846863
172cytidine metabolic process (GO:0046087)2.45543383
173cytidine catabolic process (GO:0006216)2.45543383
174cytidine deamination (GO:0009972)2.45543383
175positive regulation of interleukin-8 secretion (GO:2000484)2.44129211
176regulation of action potential (GO:0098900)2.42795605
177negative regulation of appetite (GO:0032099)2.42720861
178negative regulation of response to food (GO:0032096)2.42720861
179multicellular organism reproduction (GO:0032504)2.41251097
180ncRNA catabolic process (GO:0034661)2.39879363
181negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.39634904
182positive regulation of defense response to virus by host (GO:0002230)2.38878023
183regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.38397427
184substrate-independent telencephalic tangential migration (GO:0021826)2.38223273
185substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.38223273
186regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.37728370
187adhesion of symbiont to host cell (GO:0044650)2.36706688
188virion attachment to host cell (GO:0019062)2.36706688
189regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.35132680
190positive regulation of pseudopodium assembly (GO:0031274)2.34915290
191retinal metabolic process (GO:0042574)2.34563436
192branching involved in mammary gland duct morphogenesis (GO:0060444)2.32051608
193positive regulation of vesicle fusion (GO:0031340)2.31861913
194phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.30156012
195cell-cell junction assembly (GO:0007043)2.29363679
196calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.29238912
197cellular response to fluid shear stress (GO:0071498)2.28921358
198positive regulation of type 2 immune response (GO:0002830)2.28335256
199detection of other organism (GO:0098543)2.27519398
200positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.26509601

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.44108569
2EZH2_22144423_ChIP-Seq_EOC_Human4.37811399
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.33138593
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.59052021
5VDR_22108803_ChIP-Seq_LS180_Human3.52210526
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.19052856
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.02764098
8ZNF263_19887448_ChIP-Seq_K562_Human2.70578080
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.65351798
10ZNF274_21170338_ChIP-Seq_K562_Hela2.65034154
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46555631
12SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.44423241
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.44423241
14SOX9_24532713_ChIP-Seq_HFSC_Mouse2.42334336
15FOXO3_23340844_ChIP-Seq_DLD1_Human2.37418704
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.35808674
17ESR1_20079471_ChIP-ChIP_T-47D_Human2.28434968
18ZNF217_24962896_ChIP-Seq_MCF-7_Human2.28205108
19P63_26484246_Chip-Seq_KERATINOCYTES_Human2.26741164
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25919224
21SOX2_20726797_ChIP-Seq_SW620_Human2.20047431
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.14707593
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11325781
24IRF1_19129219_ChIP-ChIP_H3396_Human2.11296287
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.10750969
26GBX2_23144817_ChIP-Seq_PC3_Human2.09777085
27STAT6_21828071_ChIP-Seq_BEAS2B_Human2.09110009
28HIF1A_21447827_ChIP-Seq_MCF-7_Human2.02627036
29SOX2_27498859_Chip-Seq_STOMACH_Mouse2.01796315
30TP63_17297297_ChIP-ChIP_HaCaT_Human12.2811191
31FUS_26573619_Chip-Seq_HEK293_Human1.94520011
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92528320
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.92081913
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.88456813
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.88167300
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85187025
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.82428273
38CJUN_26792858_Chip-Seq_BT549_Human1.80463968
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78051229
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.76756192
41ER_23166858_ChIP-Seq_MCF-7_Human1.76246492
42* GATA4_25053715_ChIP-Seq_YYC3_Human1.75093142
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74053939
44* P300_19829295_ChIP-Seq_ESCs_Human1.73845247
45EWS_26573619_Chip-Seq_HEK293_Human1.73580393
46CDX2_20551321_ChIP-Seq_CACO-2_Human1.71234854
47* GATA6_25053715_ChIP-Seq_YYC3_Human1.70875286
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70872169
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70790221
50AHR_22903824_ChIP-Seq_MCF-7_Human1.67109439
51* RUNX1_27514584_Chip-Seq_MCF-7_Human1.66602898
52REST_21632747_ChIP-Seq_MESCs_Mouse1.64458352
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64272126
54NR3C1_21868756_ChIP-Seq_MCF10A_Human1.62444875
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.62300315
56SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.62118062
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60513182
58STAT3_23295773_ChIP-Seq_U87_Human1.59760982
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58704378
60CBP_20019798_ChIP-Seq_JUKART_Human1.58704378
61CLOCK_20551151_ChIP-Seq_293T_Human1.58597369
62FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.58308579
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57497785
64* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56434340
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55335016
66ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.54486374
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54234741
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53977658
69FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53146318
70KLF5_25053715_ChIP-Seq_YYC3_Human1.51997948
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51973012
72* TCF4_23295773_ChIP-Seq_U87_Human1.45742032
73TAF15_26573619_Chip-Seq_HEK293_Human1.43683276
74RNF2_27304074_Chip-Seq_NSC_Mouse1.42472116
75ATF3_27146783_Chip-Seq_COLON_Human1.40666985
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40624271
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40624271
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40406427
79* GATA3_24758297_ChIP-Seq_MCF-7_Human1.39678832
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39318250
81GATA1_22025678_ChIP-Seq_K562_Human1.38450649
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38358656
83SMAD4_21799915_ChIP-Seq_A2780_Human1.37349634
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36805084
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36149224
86RACK7_27058665_Chip-Seq_MCF-7_Human1.35362738
87TP63_23658742_ChIP-Seq_EP156T_Human1.34109094
88TP53_18474530_ChIP-ChIP_U2OS_Human1.32326568
89TCF4_18268006_ChIP-ChIP_LS174T_Human1.31959984
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.31344833
91* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31207084
92BCAT_22108803_ChIP-Seq_LS180_Human1.29917292
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29807799
94IGF1R_20145208_ChIP-Seq_DFB_Human1.29773942
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29432739
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28103733
97JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26571428
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24788310
99TCF4_22108803_ChIP-Seq_LS180_Human1.24749206
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.23202622
101FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22706620
102FOXA1_25329375_ChIP-Seq_VCAP_Human1.22706620
103PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22689135
104* NCOR_22424771_ChIP-Seq_293T_Human1.22237873
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.21664927
106EGR1_19374776_ChIP-ChIP_THP-1_Human1.21095916
107BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20591953
108EZH2_27304074_Chip-Seq_ESCs_Mouse1.19170483
109* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17739621
110* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17638447
111JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17483118
112EZH2_27294783_Chip-Seq_ESCs_Mouse1.17250713
113UBF1/2_26484160_Chip-Seq_HMECs_Human1.17127967
114NANOG_19829295_ChIP-Seq_ESCs_Human1.17039703
115SOX2_19829295_ChIP-Seq_ESCs_Human1.17039703
116MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17018112
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16836053
118AR_25329375_ChIP-Seq_VCAP_Human1.16441989
119* CDX2_22108803_ChIP-Seq_LS180_Human1.15150929
120TP53_22573176_ChIP-Seq_HFKS_Human1.14463802
121SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14063771
122FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13348102
123RUNX2_22187159_ChIP-Seq_PCA_Human1.12750672
124NANOG_18555785_Chip-Seq_ESCs_Mouse1.12027582
125HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11246005
126GATA3_21878914_ChIP-Seq_MCF-7_Human1.11230492
127STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10786425
128SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10240940
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09978674
130IRF8_22096565_ChIP-ChIP_GC-B_Human1.09748669
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09459069
132GATA2_21666600_ChIP-Seq_HMVEC_Human1.08880522
133EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.08308692
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07773408
135NFE2_27457419_Chip-Seq_LIVER_Mouse1.07550249
136HOXB7_26014856_ChIP-Seq_BT474_Human1.06803820
137* SMAD3_21741376_ChIP-Seq_EPCs_Human1.05887037
138* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05081976
139PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05029999
140TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04244804
141* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04227681
142EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03525168
143FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03277865
144JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02313869
145RXR_22108803_ChIP-Seq_LS180_Human1.01605861
146AR_20517297_ChIP-Seq_VCAP_Human1.00963455
147SALL1_21062744_ChIP-ChIP_HESCs_Human1.00697066
148P53_22387025_ChIP-Seq_ESCs_Mouse1.00321989
149SMAD4_21741376_ChIP-Seq_EPCs_Human0.99787147
150JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99763564
151P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99427680
152TAL1_26923725_Chip-Seq_HPCs_Mouse0.99107638
153NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98720919
154NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98720919
155ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98693560
156BRD4_25478319_ChIP-Seq_HGPS_Human0.98416617
157STAT3_18555785_Chip-Seq_ESCs_Mouse0.97944324
158AR_21572438_ChIP-Seq_LNCaP_Human0.97840259
159EGR1_19032775_ChIP-ChIP_M12_Human0.97552440
160CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96520467
161* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96192197
162CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96189392
163SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95503360
164FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95008612
165ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94385153
166AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89433195
167SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87186577
168ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86156466
169P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84178243
170EP300_21415370_ChIP-Seq_HL-1_Mouse0.83691056
171PIAS1_25552417_ChIP-Seq_VCAP_Human0.82947423
172* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.82413309
173RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82291571
174CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.79635370
175TP53_16413492_ChIP-PET_HCT116_Human0.79587840
176BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78043169
177CHD1_26751641_Chip-Seq_LNCaP_Human0.77468307
178UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.77247234
179ELF5_23300383_ChIP-Seq_T47D_Human0.73494331
180CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.73413503
181STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.70176976
182* TP63_22573176_ChIP-Seq_HFKS_Human0.70128659
183BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69219216
184NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.67342625
185EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.67249221
186PPARA_22158963_ChIP-Seq_LIVER_Mouse0.64327704
187ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.63750549
188FOXA1_25552417_ChIP-Seq_VCAP_Human0.63611185
189TBX20_22328084_ChIP-Seq_HEART_Mouse0.63264215
190TBX20_22080862_ChIP-Seq_HEART_Mouse0.63264215
191IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.62569219

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.98880855
2MP0002796_impaired_skin_barrier4.61996316
3MP0008004_abnormal_stomach_pH3.91818229
4MP0010678_abnormal_skin_adnexa3.81229538
5MP0000383_abnormal_hair_follicle3.74361364
6MP0005275_abnormal_skin_tensile3.74264488
7MP0003646_muscle_fatigue3.69989594
8MP0002254_reproductive_system_inflammat3.49884071
9MP0003941_abnormal_skin_development3.18699828
10MP0002098_abnormal_vibrissa_morphology2.96976393
11MP0000579_abnormal_nail_morphology2.96922229
12MP0003453_abnormal_keratinocyte_physiol2.95881862
13MP0005501_abnormal_skin_physiology2.92084646
14MP0000566_synostosis2.90587329
15MP0006292_abnormal_olfactory_placode2.86804652
16MP0002060_abnormal_skin_morphology2.81196572
17MP0003195_calcinosis2.68900550
18MP0003787_abnormal_imprinting2.67612470
19MP0001216_abnormal_epidermal_layer2.66105650
20MP0008877_abnormal_DNA_methylation2.60117617
21MP0002837_dystrophic_cardiac_calcinosis2.58049972
22MP0002163_abnormal_gland_morphology2.53422170
23MP0004381_abnormal_hair_follicle2.38566331
24MP0000537_abnormal_urethra_morphology2.32497147
25MP0003566_abnormal_cell_adhesion2.25499772
26MP0000647_abnormal_sebaceous_gland2.23148965
27MP0003705_abnormal_hypodermis_morpholog2.22648419
28MP0000377_abnormal_hair_follicle2.19646254
29MP0005646_abnormal_pituitary_gland2.19595593
30MP0010771_integument_phenotype2.13436762
31MP0004947_skin_inflammation2.12937701
32MP0004782_abnormal_surfactant_physiolog2.10709139
33MP0002876_abnormal_thyroid_physiology2.10496558
34MP0001346_abnormal_lacrimal_gland2.08998988
35MP0008875_abnormal_xenobiotic_pharmacok2.02976681
36MP0008872_abnormal_physiological_respon1.99079482
37MP0010352_gastrointestinal_tract_polyps1.90844525
38MP0003300_gastrointestinal_ulcer1.90748385
39MP0000427_abnormal_hair_cycle1.83654978
40MP0004264_abnormal_extraembryonic_tissu1.83395757
41MP0005379_endocrine/exocrine_gland_phen1.81970528
42MP0001485_abnormal_pinna_reflex1.81442360
43MP0006276_abnormal_autonomic_nervous1.81170466
44MP0002160_abnormal_reproductive_system1.78161007
45MP0005551_abnormal_eye_electrophysiolog1.76947251
46MP0002928_abnormal_bile_duct1.72173602
47MP0005084_abnormal_gallbladder_morpholo1.68400226
48MP0005645_abnormal_hypothalamus_physiol1.67372125
49MP0003252_abnormal_bile_duct1.67005931
50MP0000762_abnormal_tongue_morphology1.65049156
51MP0000467_abnormal_esophagus_morphology1.61150543
52MP0004043_abnormal_pH_regulation1.59065453
53MP0002638_abnormal_pupillary_reflex1.58709491
54MP0002009_preneoplasia1.57788489
55MP0006054_spinal_hemorrhage1.55024298
56MP0010386_abnormal_urinary_bladder1.49934119
57MP0000631_abnormal_neuroendocrine_gland1.49336269
58MP0003890_abnormal_embryonic-extraembry1.49138222
59MP0005389_reproductive_system_phenotype1.49073709
60MP0001188_hyperpigmentation1.48248308
61MP0004885_abnormal_endolymph1.46664814
62MP0000627_abnormal_mammary_gland1.39880916
63MP0001348_abnormal_lacrimal_gland1.35811524
64MP0004145_abnormal_muscle_electrophysio1.34144898
65MP0009053_abnormal_anal_canal1.32836711
66MP0005248_abnormal_Harderian_gland1.32680993
67MP0001191_abnormal_skin_condition1.32259502
68MP0002653_abnormal_ependyma_morphology1.31036804
69MP0003866_abnormal_defecation1.29658650
70MP0002234_abnormal_pharynx_morphology1.29538754
71MP0005076_abnormal_cell_differentiation1.27707168
72MP0001881_abnormal_mammary_gland1.26119979
73MP0005083_abnormal_biliary_tract1.25177488
74MP0003011_delayed_dark_adaptation1.24759207
75MP0001849_ear_inflammation1.24265807
76MP0000470_abnormal_stomach_morphology1.24087542
77MP0010030_abnormal_orbit_morphology1.22554937
78MP0000372_irregular_coat_pigmentation1.21335003
79MP0002877_abnormal_melanocyte_morpholog1.20570175
80MP0004019_abnormal_vitamin_homeostasis1.20375705
81MP0005023_abnormal_wound_healing1.19275759
82MP0009931_abnormal_skin_appearance1.18742390
83MP0008789_abnormal_olfactory_epithelium1.17023649
84MP0004133_heterotaxia1.16215771
85MP0001440_abnormal_grooming_behavior1.15196629
86MP0004142_abnormal_muscle_tone1.15064427
87MP0001243_abnormal_dermal_layer1.14657202
88MP0001765_abnormal_ion_homeostasis1.14012922
89MP0002272_abnormal_nervous_system1.13479996
90MP0001984_abnormal_olfaction1.13321288
91MP0003718_maternal_effect1.12483268
92MP0001919_abnormal_reproductive_system1.11473284
93MP0000367_abnormal_coat/_hair1.11357066
94MP0008057_abnormal_DNA_replication1.11100163
95MP0002693_abnormal_pancreas_physiology1.10731671
96MP0001958_emphysema1.10057210
97MP0004147_increased_porphyrin_level1.09493715
98MP0009745_abnormal_behavioral_response1.08605861
99MP0001501_abnormal_sleep_pattern1.08214112
100MP0004185_abnormal_adipocyte_glucose1.07435039
101MP0004272_abnormal_basement_membrane1.07128521
102MP0003123_paternal_imprinting1.07082391
103MP0002282_abnormal_trachea_morphology1.07011508
104MP0003879_abnormal_hair_cell1.06924626
105MP0006072_abnormal_retinal_apoptosis1.06812972
106MP0001666_abnormal_nutrient_absorption1.06117204
107MP0002166_altered_tumor_susceptibility1.05752027
108MP0005220_abnormal_exocrine_pancreas1.04680542
109MP0002102_abnormal_ear_morphology1.04035240
110MP0005671_abnormal_response_to1.03573957
111MP0002006_tumorigenesis1.03529595
112MP0005499_abnormal_olfactory_system1.02846763
113MP0005394_taste/olfaction_phenotype1.02846763
114MP0009046_muscle_twitch1.02739280
115MP0002295_abnormal_pulmonary_circulatio1.00238225
116MP0002557_abnormal_social/conspecific_i0.98608993
117MP0001851_eye_inflammation0.97951254
118MP0002184_abnormal_innervation0.96099868
119MP0008775_abnormal_heart_ventricle0.95310284
120MP0001944_abnormal_pancreas_morphology0.94888703
121MP0001968_abnormal_touch/_nociception0.94732021
122MP0000230_abnormal_systemic_arterial0.93597178
123MP0001873_stomach_inflammation0.91605606
124MP0001986_abnormal_taste_sensitivity0.91537033
125MP0000026_abnormal_inner_ear0.90928961
126MP0002733_abnormal_thermal_nociception0.90606452
127MP0002909_abnormal_adrenal_gland0.90526959
128MP0004130_abnormal_muscle_cell0.89570944
129MP0003880_abnormal_central_pattern0.89226726
130MP0005195_abnormal_posterior_eye0.88882419
131MP0005377_hearing/vestibular/ear_phenot0.88132223
132MP0003878_abnormal_ear_physiology0.88132223
133MP0009384_cardiac_valve_regurgitation0.87866858
134MP0005332_abnormal_amino_acid0.87270310
135MP0005360_urolithiasis0.86981338
136MP0008995_early_reproductive_senescence0.85358193
137MP0003567_abnormal_fetal_cardiomyocyte0.84959793
138MP0001177_atelectasis0.84358172
139MP0002752_abnormal_somatic_nervous0.82557902
140MP0000538_abnormal_urinary_bladder0.81833673
141MP0002136_abnormal_kidney_physiology0.79855696
142MP0005423_abnormal_somatic_nervous0.79777077
143MP0003121_genomic_imprinting0.78753676
144MP0001664_abnormal_digestion0.78609111
145MP0005410_abnormal_fertilization0.78529430
146MP0003191_abnormal_cellular_cholesterol0.78219964
147MP0001790_abnormal_immune_system0.77958426
148MP0005387_immune_system_phenotype0.77958426
149MP0002138_abnormal_hepatobiliary_system0.77567120
150MP0001340_abnormal_eyelid_morphology0.77452422
151MP0001970_abnormal_pain_threshold0.77086833
152MP0003938_abnormal_ear_development0.77043223
153MP0009764_decreased_sensitivity_to0.76758686
154MP0005388_respiratory_system_phenotype0.75040708
155MP0002133_abnormal_respiratory_system0.75040708
156MP0000462_abnormal_digestive_system0.72721044
157MP0000858_altered_metastatic_potential0.70983500
158MP0005408_hypopigmentation0.70678094
159MP0010155_abnormal_intestine_physiology0.69627368
160MP0005187_abnormal_penis_morphology0.69529499
161MP0000516_abnormal_urinary_system0.68240090
162MP0005367_renal/urinary_system_phenotyp0.68240090
163MP0005508_abnormal_skeleton_morphology0.61727325
164MP0002896_abnormal_bone_mineralization0.61460788
165MP0002277_abnormal_respiratory_mucosa0.55901490
166MP0003136_yellow_coat_color0.54722722
167MP0009379_abnormal_foot_pigmentation0.54358345
168MP0003091_abnormal_cell_migration0.54103767
169MP0005623_abnormal_meninges_morphology0.53886859
170MP0000477_abnormal_intestine_morphology0.53886515
171MP0003045_fibrosis0.53118595
172MP0003448_altered_tumor_morphology0.52679163
173MP0003115_abnormal_respiratory_system0.51970978
174MP0003936_abnormal_reproductive_system0.51747412
175MP0000767_abnormal_smooth_muscle0.49376131
176MP0008961_abnormal_basal_metabolism0.47966015
177MP0005165_increased_susceptibility_to0.47940050
178MP0002177_abnormal_outer_ear0.46784984
179MP0001533_abnormal_skeleton_physiology0.45896280
180MP0001853_heart_inflammation0.45817015
181MP0008438_abnormal_cutaneous_collagen0.45457765
182MP0000613_abnormal_salivary_gland0.45217843
183MP0002233_abnormal_nose_morphology0.45084974
184MP0003436_decreased_susceptibility_to0.44603266
185MP0003755_abnormal_palate_morphology0.44142996
186MP0001784_abnormal_fluid_regulation0.43687886
187MP0000432_abnormal_head_morphology0.42785425

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)7.09331617
2Milia (HP:0001056)6.78206540
3Right ventricular cardiomyopathy (HP:0011663)6.18971359
4Fragile nails (HP:0001808)5.69213099
5Plantar hyperkeratosis (HP:0007556)5.44773925
6Pili torti (HP:0003777)4.83419961
7Woolly hair (HP:0002224)4.68986555
8Hypotrichosis (HP:0001006)4.62866144
9Atrophic scars (HP:0001075)4.56689966
10Thick nail (HP:0001805)4.04742510
11Lip pit (HP:0100267)4.00025761
12Interstitial pulmonary disease (HP:0006530)3.99907817
13Palmoplantar hyperkeratosis (HP:0000972)3.98404624
14Congenital ichthyosiform erythroderma (HP:0007431)3.94802924
15Pancreatic cysts (HP:0001737)3.92266512
16Palmar hyperkeratosis (HP:0010765)3.76796184
17Nail dystrophy (HP:0008404)3.68929771
18Curly hair (HP:0002212)3.49957194
19Abnormality of nail color (HP:0100643)3.45998133
20Congenital stationary night blindness (HP:0007642)3.43720962
21Pancreatic fibrosis (HP:0100732)3.42397433
22True hermaphroditism (HP:0010459)3.34564230
23Decreased circulating renin level (HP:0003351)3.29031825
24Stenosis of the external auditory canal (HP:0000402)3.26152245
25Nephronophthisis (HP:0000090)3.23609771
26Alopecia of scalp (HP:0002293)3.21440355
27Natal tooth (HP:0000695)3.11633000
28Molar tooth sign on MRI (HP:0002419)3.11610373
29Abnormality of midbrain morphology (HP:0002418)3.11610373
30Parakeratosis (HP:0001036)3.11512352
31Abnormal blistering of the skin (HP:0008066)3.10316960
32Abnormal pancreas size (HP:0012094)3.07879673
33Abnormality of the renal medulla (HP:0100957)2.97825828
34Hypoplastic labia majora (HP:0000059)2.96739359
35Advanced eruption of teeth (HP:0006288)2.95707557
36Abnormality of the renal cortex (HP:0011035)2.93868995
37Abnormal rod and cone electroretinograms (HP:0008323)2.92057233
38Tubular atrophy (HP:0000092)2.91298151
39Popliteal pterygium (HP:0009756)2.88829628
40Increased IgE level (HP:0003212)2.77522944
41Absent rod-and cone-mediated responses on ERG (HP:0007688)2.77127641
42Aplasia cutis congenita (HP:0001057)2.75231572
43Abnormality of cells of the erythroid lineage (HP:0012130)2.74502076
44Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.73865205
45Ridged nail (HP:0001807)2.73484720
46Rectal prolapse (HP:0002035)2.70639631
47Hypoplasia of dental enamel (HP:0006297)2.70139738
48Dynein arm defect of respiratory motile cilia (HP:0012255)2.69366873
49Absent/shortened dynein arms (HP:0200106)2.69366873
50Decreased central vision (HP:0007663)2.69257165
51Abnormality of the labia majora (HP:0012881)2.69071495
52Asplenia (HP:0001746)2.57787681
53Aplasia/Hypoplasia of the spleen (HP:0010451)2.57559149
54Abnormal hair laboratory examination (HP:0003328)2.55991499
55Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.54513693
56Chronic hepatic failure (HP:0100626)2.52569805
57Chronic bronchitis (HP:0004469)2.51585063
58Abnormality of macular pigmentation (HP:0008002)2.50917606
59Abnormality of the gastric mucosa (HP:0004295)2.50146785
60Pustule (HP:0200039)2.49995350
61Abolished electroretinogram (ERG) (HP:0000550)2.48802091
62Abnormal respiratory motile cilium physiology (HP:0012261)2.47379983
63Abnormality of the nasal septum (HP:0000419)2.46864989
64Cystic liver disease (HP:0006706)2.46788163
65Pterygium (HP:0001059)2.46638921
66Abnormal hemoglobin (HP:0011902)2.46017660
67Hypoplasia of the uterus (HP:0000013)2.45654916
68Abnormal drinking behavior (HP:0030082)2.43080422
69Polydipsia (HP:0001959)2.43080422
70Pendular nystagmus (HP:0012043)2.40941662
71Medial flaring of the eyebrow (HP:0010747)2.40748840
72Fragile skin (HP:0001030)2.40410087
73Concave nail (HP:0001598)2.40197344
74Abnormal respiratory motile cilium morphology (HP:0005938)2.36156726
75Abnormal respiratory epithelium morphology (HP:0012253)2.36156726
76Aplasia involving bones of the upper limbs (HP:0009823)2.33860318
77Aplasia of the phalanges of the hand (HP:0009802)2.33860318
78Aplasia involving bones of the extremities (HP:0009825)2.33860318
79Distal lower limb muscle weakness (HP:0009053)2.33494289
80Genetic anticipation (HP:0003743)2.33416778
81Acanthosis nigricans (HP:0000956)2.33168308
82Abnormal ciliary motility (HP:0012262)2.32891849
83Ventricular tachycardia (HP:0004756)2.32037649
84Chorioretinal atrophy (HP:0000533)2.30310001
85Progressive cerebellar ataxia (HP:0002073)2.29066530
86Conical tooth (HP:0000698)2.28240667
87Blepharitis (HP:0000498)2.28016259
88Rhinitis (HP:0012384)2.27421864
89Decreased electroretinogram (ERG) amplitude (HP:0000654)2.27156169
90Attenuation of retinal blood vessels (HP:0007843)2.26167001
91Aplasia/hypoplasia of the uterus (HP:0008684)2.25980672
92Osteolytic defects of the hand bones (HP:0009699)2.25487622
93Osteolytic defects of the phalanges of the hand (HP:0009771)2.25487622
94Sparse eyelashes (HP:0000653)2.24764768
95Corneal erosion (HP:0200020)2.23894808
96Short nail (HP:0001799)2.23567182
97Adrenal hypoplasia (HP:0000835)2.22107852
98Ectropion (HP:0000656)2.18431302
99Agitation (HP:0000713)2.16402906
100Bronchiectasis (HP:0002110)2.16148538
101Erythema (HP:0010783)2.15917603
102Erythroderma (HP:0001019)2.15139800
103Sparse scalp hair (HP:0002209)2.14804361
104Anhidrosis (HP:0000970)2.14461904
105Stomach cancer (HP:0012126)2.13500498
106Abnormality of renin-angiotensin system (HP:0000847)2.12954093
107Humeroradial synostosis (HP:0003041)2.12596787
108Synostosis involving the elbow (HP:0003938)2.12596787
109Abnormality of the distal phalanges of the toes (HP:0010182)2.10560126
110Type II lissencephaly (HP:0007260)2.09937987
111Furrowed tongue (HP:0000221)2.09822029
112Oligodontia (HP:0000677)2.08020047
113Abnormal number of erythroid precursors (HP:0012131)2.06765211
114Hypohidrosis (HP:0000966)2.06528963
115Micronodular cirrhosis (HP:0001413)2.06392001
116Hypodontia (HP:0000668)2.05481687
117Absent eyebrow (HP:0002223)2.04360735
118Congenital, generalized hypertrichosis (HP:0004540)2.01880040
119Polyuria (HP:0000103)2.00186110
120Hyporeflexia of lower limbs (HP:0002600)1.99654166
121Aplasia/Hypoplasia of the tibia (HP:0005772)1.99404124
122Abnormality of the renal collecting system (HP:0004742)1.97874012
123Methylmalonic aciduria (HP:0012120)1.95742431
124Recurrent sinusitis (HP:0011108)1.95372518
125Esophageal atresia (HP:0002032)1.94273026
126Broad-based gait (HP:0002136)1.92426908
127Abnormality of renal excretion (HP:0011036)1.92011384
128Gaze-evoked nystagmus (HP:0000640)1.91856668
129Abnormality of the pons (HP:0007361)1.91434786
130Severe visual impairment (HP:0001141)1.90213510
131Sclerocornea (HP:0000647)1.89868447
132Biliary tract neoplasm (HP:0100574)1.89725117
133Premature skin wrinkling (HP:0100678)1.88986573
134Enlarged kidneys (HP:0000105)1.88525412
135Methylmalonic acidemia (HP:0002912)1.87928864
136Male pseudohermaphroditism (HP:0000037)1.87902238
137Chronic otitis media (HP:0000389)1.87346251
138Bronchomalacia (HP:0002780)1.87296571
139IgG deficiency (HP:0004315)1.86873004
140Bony spicule pigmentary retinopathy (HP:0007737)1.86654850
141Pruritus (HP:0000989)1.86598301
142Genital tract atresia (HP:0001827)1.86371601
143Gait imbalance (HP:0002141)1.85735805
144Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.84566118
145Abnormality of the salivary glands (HP:0010286)1.84379301
146Vaginal atresia (HP:0000148)1.83454197
147Subacute progressive viral hepatitis (HP:0006572)1.82697104
148Renal cortical cysts (HP:0000803)1.81733249
149Germ cell neoplasia (HP:0100728)1.81603654
150Metabolic alkalosis (HP:0200114)1.81480813
151Abnormality of the proximal phalanges of the hand (HP:0009834)1.81125513
152Congenital primary aphakia (HP:0007707)1.80703621
153Palmoplantar keratoderma (HP:0000982)1.80658400
154Anencephaly (HP:0002323)1.80471165
155Increased corneal curvature (HP:0100692)1.79311424
156Keratoconus (HP:0000563)1.79311424
157Nephrogenic diabetes insipidus (HP:0009806)1.77975983
158Congenital hepatic fibrosis (HP:0002612)1.77573104
159Thyroid-stimulating hormone excess (HP:0002925)1.77301747
160Fatigable weakness (HP:0003473)1.77217806
161Abnormality of the neuromuscular junction (HP:0003398)1.77217806
162Shallow orbits (HP:0000586)1.76437992
163Potter facies (HP:0002009)1.76419376
164Facial shape deformation (HP:0011334)1.76419376
165Abnormality of the phalanges of the 5th finger (HP:0004213)1.75449276
166Alveolar cell carcinoma (HP:0006519)1.74606364
167Conjunctival hamartoma (HP:0100780)1.74144040
168Premature rupture of membranes (HP:0001788)1.74022452
169Congenital sensorineural hearing impairment (HP:0008527)1.72451903
170Focal segmental glomerulosclerosis (HP:0000097)1.72399806
171Aplasia/Hypoplasia of the patella (HP:0006498)1.70882445
172Glomerulosclerosis (HP:0000096)1.70054049
173Labial hypoplasia (HP:0000066)1.69785526
174Skin ulcer (HP:0200042)1.69711226
175Aplasia/Hypoplasia of the tongue (HP:0010295)1.69431117
176Hyperactive renin-angiotensin system (HP:0000841)1.68204736
177Symphalangism affecting the phalanges of the hand (HP:0009773)1.67972285
178Hypoplasia of the pons (HP:0012110)1.67661096
179Absent thumb (HP:0009777)1.67575860
180Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.67545511
181Esophageal varix (HP:0002040)1.66195028
182Submucous cleft hard palate (HP:0000176)1.64503384
183Neoplasm of the adrenal cortex (HP:0100641)1.64290985
184Optic nerve hypoplasia (HP:0000609)1.63863531
185Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63595244
186Neoplasm of the tracheobronchial system (HP:0100552)1.63417648
187Abnormal urine output (HP:0012590)1.62692865
188Abnormality of vitamin B metabolism (HP:0004340)1.62682357
189Down-sloping shoulders (HP:0200021)1.62474813
190Patellar aplasia (HP:0006443)1.62293492
191Dehydration (HP:0001944)1.61788276
192Abnormality of the 2nd finger (HP:0004100)1.61037410
193Follicular hyperkeratosis (HP:0007502)1.60934750
194Coronal craniosynostosis (HP:0004440)1.59085266
195Nasolacrimal duct obstruction (HP:0000579)1.58130641
196Abnormality of permanent molar morphology (HP:0011071)1.57757638
197Taurodontia (HP:0000679)1.57757638

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.57356435
2RIPK14.43862850
3MST1R3.80228541
4MST43.79705762
5LATS13.05751605
6GRK12.90774616
7FER2.77245986
8TAOK32.64128096
9ADRBK22.42712117
10CASK2.38566384
11RPS6KB22.34342685
12ACVR1B2.33506669
13EPHA32.12936524
14TLK12.12788734
15FGFR22.07504349
16MAP3K31.98159114
17EPHB21.87841657
18FRK1.86651123
19TRPM71.84910137
20LRRK21.82343415
21MET1.79069570
22MAP3K21.73394086
23PTK61.72796380
24MAPKAPK31.68297079
25EPHB11.64553036
26MKNK21.64031379
27STK101.63435452
28WNK31.61186852
29STK241.59605384
30ZAK1.57760280
31MAP3K91.56906273
32TXK1.50677821
33ERBB31.40313561
34ERBB41.38371881
35MAP3K41.37729306
36PTK21.36887390
37STK31.36733671
38TNIK1.36476682
39STK391.34874961
40SGK21.33317662
41PBK1.32595469
42ERN11.28286641
43TGFBR21.28161811
44TRIB31.27042274
45PINK11.26131350
46MAPK131.21951433
47INSRR1.21272351
48NTRK31.20921799
49SGK2231.15529474
50SGK4941.15529474
51TESK11.13677559
52PRKCQ1.11668259
53CDK61.11664743
54MAP4K21.10049234
55STK38L1.08887394
56FGFR41.08505129
57AKT31.03893710
58DYRK21.01305927
59SIK10.99005918
60RPS6KA40.97070589
61FGFR30.95463218
62MAP3K100.93240323
63MAP2K60.92212332
64FGFR10.89264115
65TEC0.88471758
66BMX0.87051839
67CSNK1A1L0.86862200
68NEK90.83337119
69LMTK20.83250197
70DAPK20.77919389
71BLK0.76040076
72DMPK0.75769454
73PIM20.75331920
74PRKCG0.74806665
75TTN0.74314245
76CSNK1G20.74207167
77EEF2K0.74071243
78ADRBK10.73804989
79IKBKE0.73477916
80MAP2K20.71620014
81JAK30.70813748
82LIMK10.69194033
83SGK10.69072371
84MKNK10.68316873
85TIE10.68285626
86ERBB20.67979775
87MAP3K140.67943412
88BTK0.67927183
89MAP3K10.67530827
90BCR0.66490297
91STK160.66363847
92PAK40.65068023
93KIT0.64311418
94ITK0.64246858
95MAP3K120.62875041
96IRAK30.62599869
97CHUK0.60895705
98MAP2K70.60616582
99SGK30.59731175
100PKN20.58685864
101LATS20.58039068
102PDGFRB0.57464407
103MAPKAPK20.57315197
104CSNK1A10.57082725
105TBK10.56554638
106PRKCH0.56515261
107ILK0.56266203
108NME10.55034021
109STK110.54565541
110NEK60.53995421
111MATK0.53635264
112WNK10.52674428
113PRKACA0.51550717
114PLK20.51448215
115WNK40.51058552
116DYRK30.51039353
117IKBKB0.50171204
118PRKCA0.49863710
119TAF10.49679924
120MAP2K10.49426363
121PASK0.49162487
122ICK0.48423563
123JAK10.47597922
124BMPR1B0.47157142
125MAPK150.46728884
126TRIM280.45877907
127EIF2AK30.44673823
128TAOK10.44452189
129DDR20.44290004
130DYRK1B0.43316410
131JAK20.42903680
132PIK3CA0.42489856
133LCK0.42080274
134EGFR0.40608439
135TGFBR10.40451331
136RPS6KA20.40262067
137RPS6KA60.37949445
138PIK3CG0.37944218
139NME20.37122910
140BCKDK0.37001393
141PDGFRA0.36394775
142NLK0.35212230
143CAMK1D0.34860449
144MUSK0.34738571
145PAK20.34663830
146PRKCE0.34623676
147IGF1R0.34173241
148PRKCI0.34166442
149RPS6KA50.33901312
150BRSK20.33830925
151SYK0.33632440
152CSNK1E0.33618805
153CSNK1G30.33409468
154PAK30.32743853
155PRKAA10.32487106
156IRAK10.32234815
157GSK3A0.31161016
158MAPKAPK50.30702782
159PRKCZ0.30405367
160ABL10.30239067
161ROCK20.26624984
162MAP3K110.26203612
163OXSR10.25974285
164TYK20.24904248
165SRC0.24896097
166NUAK10.24747874
167ALK0.23655965
168RPS6KA10.23382608
169ZAP700.23124975

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.18213741
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.94610064
3Phototransduction_Homo sapiens_hsa047442.87372014
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.48740633
5ECM-receptor interaction_Homo sapiens_hsa045122.45689374
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.45562621
7Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.39499423
8Adherens junction_Homo sapiens_hsa045202.36487355
9Nicotine addiction_Homo sapiens_hsa050332.33670292
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.29168994
11Caffeine metabolism_Homo sapiens_hsa002322.11232327
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.06477056
13Tight junction_Homo sapiens_hsa045301.98945535
14Hippo signaling pathway_Homo sapiens_hsa043901.87474149
15Amoebiasis_Homo sapiens_hsa051461.85018086
16Small cell lung cancer_Homo sapiens_hsa052221.83582860
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.83541891
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.83020412
19Proteoglycans in cancer_Homo sapiens_hsa052051.79197813
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.78772317
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.78755023
22Nitrogen metabolism_Homo sapiens_hsa009101.76842193
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.76090800
24Phenylalanine metabolism_Homo sapiens_hsa003601.72335391
25Bladder cancer_Homo sapiens_hsa052191.71558758
26Toxoplasmosis_Homo sapiens_hsa051451.68546290
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.66174429
28Mineral absorption_Homo sapiens_hsa049781.64714453
29Thyroid cancer_Homo sapiens_hsa052161.57405928
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55119709
31Oxidative phosphorylation_Homo sapiens_hsa001901.54360534
32Ribosome_Homo sapiens_hsa030101.54197167
33Tryptophan metabolism_Homo sapiens_hsa003801.53179175
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48962762
35Linoleic acid metabolism_Homo sapiens_hsa005911.47651971
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47454971
37Glycerolipid metabolism_Homo sapiens_hsa005611.46017414
38Focal adhesion_Homo sapiens_hsa045101.44329537
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.40016554
40RNA degradation_Homo sapiens_hsa030181.39352301
41Basal cell carcinoma_Homo sapiens_hsa052171.37216157
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.37173006
43Olfactory transduction_Homo sapiens_hsa047401.35550765
44Chemical carcinogenesis_Homo sapiens_hsa052041.34968560
45Pertussis_Homo sapiens_hsa051331.34349760
46Selenocompound metabolism_Homo sapiens_hsa004501.30418864
47Serotonergic synapse_Homo sapiens_hsa047261.29391530
48Hepatitis C_Homo sapiens_hsa051601.28010392
49TNF signaling pathway_Homo sapiens_hsa046681.25169020
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22827934
51Vitamin digestion and absorption_Homo sapiens_hsa049771.22660123
52Basal transcription factors_Homo sapiens_hsa030221.21861180
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.21591566
54Ether lipid metabolism_Homo sapiens_hsa005651.20148543
55Morphine addiction_Homo sapiens_hsa050321.18821769
56Glutathione metabolism_Homo sapiens_hsa004801.18115878
57Histidine metabolism_Homo sapiens_hsa003401.16699300
58Viral myocarditis_Homo sapiens_hsa054161.15763319
59Malaria_Homo sapiens_hsa051441.15007670
60RNA polymerase_Homo sapiens_hsa030201.13928594
61Salmonella infection_Homo sapiens_hsa051321.13349615
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13043964
63Primary immunodeficiency_Homo sapiens_hsa053401.12988553
64Sphingolipid metabolism_Homo sapiens_hsa006001.12742033
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11496015
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10586596
67MicroRNAs in cancer_Homo sapiens_hsa052061.10217117
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10008986
69Taste transduction_Homo sapiens_hsa047421.09571777
70Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09218745
71Butanoate metabolism_Homo sapiens_hsa006501.08978675
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08337460
73Asthma_Homo sapiens_hsa053101.06291126
74Homologous recombination_Homo sapiens_hsa034401.06086724
75Leishmaniasis_Homo sapiens_hsa051401.05588598
76Pancreatic secretion_Homo sapiens_hsa049721.05519757
77Gastric acid secretion_Homo sapiens_hsa049711.05124928
78TGF-beta signaling pathway_Homo sapiens_hsa043501.02200126
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01825106
80Parkinsons disease_Homo sapiens_hsa050121.01686293
81Arachidonic acid metabolism_Homo sapiens_hsa005901.01299264
82Protein export_Homo sapiens_hsa030601.00740489
83Fatty acid biosynthesis_Homo sapiens_hsa000611.00360648
84Renal cell carcinoma_Homo sapiens_hsa052110.99625912
85Insulin secretion_Homo sapiens_hsa049110.99366402
86Dorso-ventral axis formation_Homo sapiens_hsa043200.99076801
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95100533
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94827284
89Endometrial cancer_Homo sapiens_hsa052130.93895467
90Fat digestion and absorption_Homo sapiens_hsa049750.93517406
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92255690
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92135349
93Prostate cancer_Homo sapiens_hsa052150.91623361
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91307535
95Type I diabetes mellitus_Homo sapiens_hsa049400.90717404
96Melanoma_Homo sapiens_hsa052180.90046889
97Pancreatic cancer_Homo sapiens_hsa052120.89901573
98VEGF signaling pathway_Homo sapiens_hsa043700.85971822
99Cardiac muscle contraction_Homo sapiens_hsa042600.85669635
100Huntingtons disease_Homo sapiens_hsa050160.85247718
101Pathways in cancer_Homo sapiens_hsa052000.85040270
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83444397
103Autoimmune thyroid disease_Homo sapiens_hsa053200.81796399
104Acute myeloid leukemia_Homo sapiens_hsa052210.81179479
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80432049
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.79757926
107Hedgehog signaling pathway_Homo sapiens_hsa043400.79666112
108Chronic myeloid leukemia_Homo sapiens_hsa052200.78917582
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77918262
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77261821
111Sulfur metabolism_Homo sapiens_hsa009200.76625120
112Legionellosis_Homo sapiens_hsa051340.75863692
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74986095
114Starch and sucrose metabolism_Homo sapiens_hsa005000.74968335
115ABC transporters_Homo sapiens_hsa020100.73626727
116Allograft rejection_Homo sapiens_hsa053300.73262300
117Type II diabetes mellitus_Homo sapiens_hsa049300.72583144
118GABAergic synapse_Homo sapiens_hsa047270.72508788
119Protein digestion and absorption_Homo sapiens_hsa049740.72298173
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.72240429
121Hematopoietic cell lineage_Homo sapiens_hsa046400.71966911
122Alzheimers disease_Homo sapiens_hsa050100.71306122
123Rap1 signaling pathway_Homo sapiens_hsa040150.70901646
124Osteoclast differentiation_Homo sapiens_hsa043800.69347104
125Axon guidance_Homo sapiens_hsa043600.68834630
126Peroxisome_Homo sapiens_hsa041460.67003274
127Phagosome_Homo sapiens_hsa041450.67002885
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66739193
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65647795
130Apoptosis_Homo sapiens_hsa042100.64943157
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64562212
132Shigellosis_Homo sapiens_hsa051310.64524825
133Platelet activation_Homo sapiens_hsa046110.64470828
134Antigen processing and presentation_Homo sapiens_hsa046120.63664533
135Tyrosine metabolism_Homo sapiens_hsa003500.63365226
136Graft-versus-host disease_Homo sapiens_hsa053320.63015847
137Collecting duct acid secretion_Homo sapiens_hsa049660.62092056
138Rheumatoid arthritis_Homo sapiens_hsa053230.61808848
139Vibrio cholerae infection_Homo sapiens_hsa051100.61675194
140Glutamatergic synapse_Homo sapiens_hsa047240.61286940
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60389643
142Melanogenesis_Homo sapiens_hsa049160.60101665
143Tuberculosis_Homo sapiens_hsa051520.59320545
144Glioma_Homo sapiens_hsa052140.59284089
145Cyanoamino acid metabolism_Homo sapiens_hsa004600.58558948
146NF-kappa B signaling pathway_Homo sapiens_hsa040640.58415210
147Fanconi anemia pathway_Homo sapiens_hsa034600.58217594
148Influenza A_Homo sapiens_hsa051640.57987103
149HTLV-I infection_Homo sapiens_hsa051660.57984446
150Ras signaling pathway_Homo sapiens_hsa040140.57959812
151p53 signaling pathway_Homo sapiens_hsa041150.57378747
152Retinol metabolism_Homo sapiens_hsa008300.56737300
153Cholinergic synapse_Homo sapiens_hsa047250.56094189
154Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56031411
155Prolactin signaling pathway_Homo sapiens_hsa049170.55723878
156ErbB signaling pathway_Homo sapiens_hsa040120.54526632
157Staphylococcus aureus infection_Homo sapiens_hsa051500.52883605
158Renin-angiotensin system_Homo sapiens_hsa046140.52427105
159Ovarian steroidogenesis_Homo sapiens_hsa049130.52284641
160Salivary secretion_Homo sapiens_hsa049700.51621529
161Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50098378
162Circadian entrainment_Homo sapiens_hsa047130.49061901
163Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48639200
164Long-term depression_Homo sapiens_hsa047300.46294823
165Glycerophospholipid metabolism_Homo sapiens_hsa005640.46192982
166Dopaminergic synapse_Homo sapiens_hsa047280.45162441
167beta-Alanine metabolism_Homo sapiens_hsa004100.42597417
168Propanoate metabolism_Homo sapiens_hsa006400.40395924
169Cocaine addiction_Homo sapiens_hsa050300.38196859
170Metabolic pathways_Homo sapiens_hsa011000.37200700
171Regulation of autophagy_Homo sapiens_hsa041400.36078466
172One carbon pool by folate_Homo sapiens_hsa006700.35480179

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