MACF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. The encoded protein is a member of a family of proteins that form bridges between different cytoskeletal elements. This protein facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.58487498
2negative regulation of cell killing (GO:0031342)5.58487498
3positive regulation of gamma-delta T cell activation (GO:0046645)5.00781853
4positive thymic T cell selection (GO:0045059)4.70508953
5histone H3-K4 trimethylation (GO:0080182)4.66626571
6positive T cell selection (GO:0043368)4.10332284
7nucleus localization (GO:0051647)3.83416787
8regulation of gamma-delta T cell differentiation (GO:0045586)3.81671058
9interkinetic nuclear migration (GO:0022027)3.73518740
10regulation of gamma-delta T cell activation (GO:0046643)3.68360911
11cytoplasmic mRNA processing body assembly (GO:0033962)3.63054335
12negative thymic T cell selection (GO:0045060)3.61216865
13negative T cell selection (GO:0043383)3.57881722
14histone H3-K4 methylation (GO:0051568)3.56079609
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.54477818
16thymic T cell selection (GO:0045061)3.48641473
17negative regulation of translation, ncRNA-mediated (GO:0040033)3.35409761
18regulation of translation, ncRNA-mediated (GO:0045974)3.35409761
19negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.35409761
20B cell receptor signaling pathway (GO:0050853)3.35060719
21T cell selection (GO:0045058)3.31469825
22phospholipid translocation (GO:0045332)3.28555142
23lipid translocation (GO:0034204)3.28555142
24cellular response to ethanol (GO:0071361)3.27472164
25regulation of B cell receptor signaling pathway (GO:0050855)3.20558087
26peptidyl-lysine trimethylation (GO:0018023)3.15227942
27I-kappaB phosphorylation (GO:0007252)3.11231499
28pericardium development (GO:0060039)3.10580613
29regulation of ARF protein signal transduction (GO:0032012)3.03775612
30positive regulation of histone deacetylation (GO:0031065)3.00477537
31hemidesmosome assembly (GO:0031581)2.98349011
32regulation of interferon-beta biosynthetic process (GO:0045357)2.98068481
33regulation of interleukin-12 biosynthetic process (GO:0045075)2.92874388
34positive regulation of Rap GTPase activity (GO:0032854)2.89828096
35regulation of pigment cell differentiation (GO:0050932)2.89435544
36monoubiquitinated protein deubiquitination (GO:0035520)2.84659484
37retrograde transport, vesicle recycling within Golgi (GO:0000301)2.83504963
38regulation of T cell tolerance induction (GO:0002664)2.82983886
39cytoskeletal anchoring at plasma membrane (GO:0007016)2.79979939
40B cell homeostasis (GO:0001782)2.78798633
41establishment of protein localization to Golgi (GO:0072600)2.76111414
42coronary vasculature morphogenesis (GO:0060977)2.75208532
43histone lysine methylation (GO:0034968)2.73094294
44phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.67734855
45pre-miRNA processing (GO:0031054)2.65008166
46nuclear pore complex assembly (GO:0051292)2.64014302
47regulation of ARF GTPase activity (GO:0032312)2.63836242
48B cell proliferation (GO:0042100)2.62844116
49cell-substrate junction assembly (GO:0007044)2.62592159
50histone H3-K36 demethylation (GO:0070544)2.62585514
51negative regulation of DNA repair (GO:0045738)2.62569541
52cerebellar Purkinje cell differentiation (GO:0021702)2.61273893
53activation of JUN kinase activity (GO:0007257)2.59339174
54negative regulation of myotube differentiation (GO:0010832)2.58827891
55germinal center formation (GO:0002467)2.58705329
56regulation of skeletal muscle cell differentiation (GO:2001014)2.58069207
57regulation of Rap GTPase activity (GO:0032317)2.57088110
58positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.56855620
59NLS-bearing protein import into nucleus (GO:0006607)2.54302686
60regulation of transforming growth factor beta2 production (GO:0032909)2.53828139
61cardiac myofibril assembly (GO:0055003)2.53142633
62fibroblast migration (GO:0010761)2.53114185
63locomotory exploration behavior (GO:0035641)2.52787562
64protein targeting to Golgi (GO:0000042)2.51275336
65regulation of B cell differentiation (GO:0045577)2.49875816
66cortical actin cytoskeleton organization (GO:0030866)2.48489290
67hypotonic response (GO:0006971)2.48459060
68regulation of protein polyubiquitination (GO:1902914)2.48119207
69positive regulation of developmental pigmentation (GO:0048087)2.46412034
70centrosome localization (GO:0051642)2.45871805
71positive regulation by symbiont of host defense response (GO:0052509)2.45732446
72modulation by symbiont of host defense response (GO:0052031)2.45732446
73modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.45732446
74modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.45732446
75positive regulation by organism of defense response of other organism involved in symbiotic interact2.45732446
76modulation by symbiont of host immune response (GO:0052553)2.45732446
77peptidyl-lysine methylation (GO:0018022)2.44457167
78positive regulation of B cell differentiation (GO:0045579)2.44253456
79myofibril assembly (GO:0030239)2.44189773
80positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.43716307
81histone H3-K9 demethylation (GO:0033169)2.39153884
82positive regulation of tolerance induction (GO:0002645)2.38774870
83activated T cell proliferation (GO:0050798)2.38025867
84interferon-gamma production (GO:0032609)2.38020664
85nerve growth factor signaling pathway (GO:0038180)2.36785631
86SMAD protein complex assembly (GO:0007183)2.35906505
87heart morphogenesis (GO:0003007)2.34645949
88regulation of RNA export from nucleus (GO:0046831)2.34567526
89heterotypic cell-cell adhesion (GO:0034113)2.33664553
90negative regulation of histone methylation (GO:0031061)2.33247051
91protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.33240980
92peptidyl-threonine phosphorylation (GO:0018107)2.32948170
93establishment of nucleus localization (GO:0040023)2.32815485
94cellular response to epinephrine stimulus (GO:0071872)2.32475939
95antigen receptor-mediated signaling pathway (GO:0050851)2.31871714
96response to interleukin-15 (GO:0070672)2.31739349
97regulation of nucleobase-containing compound transport (GO:0032239)2.31501568
98sodium ion export (GO:0071436)2.31069500
99negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.30646917
100modulation by symbiont of host cellular process (GO:0044068)2.29243086
101embryonic retina morphogenesis in camera-type eye (GO:0060059)2.28984677
102positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.28289481
103tolerance induction (GO:0002507)2.27668454
104platelet-derived growth factor receptor signaling pathway (GO:0048008)2.27624967
105regulation of NFAT protein import into nucleus (GO:0051532)2.26285099
106regulation of alkaline phosphatase activity (GO:0010692)2.25864419
107regulation of histone deacetylation (GO:0031063)2.24118367
108positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.23638190
109antigen processing and presentation of endogenous antigen (GO:0019883)2.23568155
110regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.23019906
111Golgi to endosome transport (GO:0006895)2.22315697
112insulin-like growth factor receptor signaling pathway (GO:0048009)2.22300105
113embryonic camera-type eye morphogenesis (GO:0048596)2.21210527
114peptidyl-threonine modification (GO:0018210)2.20995598
115protein K48-linked deubiquitination (GO:0071108)2.20934669
116interleukin-6-mediated signaling pathway (GO:0070102)2.20818400
117macrophage activation involved in immune response (GO:0002281)2.20556016
118regulation of small GTPase mediated signal transduction (GO:0051056)2.20063049
119histone lysine demethylation (GO:0070076)2.19905421
120regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.19745626
121morphogenesis of an epithelial sheet (GO:0002011)2.19316169
122negative regulation of stress fiber assembly (GO:0051497)2.18702109
123positive regulation of Rac GTPase activity (GO:0032855)2.18324019
124macroautophagy (GO:0016236)2.17661401
125lamellipodium organization (GO:0097581)2.17539552
126negative regulation of T cell mediated immunity (GO:0002710)2.17011338
127negative regulation of granulocyte differentiation (GO:0030853)2.16142814
128retina vasculature morphogenesis in camera-type eye (GO:0061299)2.16125671
129T cell migration (GO:0072678)2.14937717
130filopodium assembly (GO:0046847)2.14248556
131substrate-dependent cell migration (GO:0006929)2.14242790
132response to fluid shear stress (GO:0034405)2.14069774
133negative regulation of fatty acid transport (GO:2000192)2.12349216
134growth hormone receptor signaling pathway (GO:0060396)2.12331745
135positive regulation of Rho GTPase activity (GO:0032321)2.12259114
136regulation of histone H3-K27 methylation (GO:0061085)2.12191842
137positive regulation of JUN kinase activity (GO:0043507)2.11587184
138regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.11505643
139T cell receptor signaling pathway (GO:0050852)2.11421714
140histone H4-K16 acetylation (GO:0043984)2.11217142
141positive regulation of Ras GTPase activity (GO:0032320)2.10959565
142regulation of cardiac muscle hypertrophy (GO:0010611)2.10590591
143response to laminar fluid shear stress (GO:0034616)2.10305493
144import into cell (GO:0098657)2.09614874
145cortical cytoskeleton organization (GO:0030865)2.09579297
146cell adhesion mediated by integrin (GO:0033627)2.09326119
147clathrin coat assembly (GO:0048268)2.09250750
148regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.09015051
149regulation of muscle hypertrophy (GO:0014743)2.08779317
150regulation of establishment of cell polarity (GO:2000114)2.08662357
151negative regulation of anoikis (GO:2000811)2.08652727
152membrane assembly (GO:0071709)2.07952756
153definitive hemopoiesis (GO:0060216)2.07402473
154negative regulation of neurotransmitter secretion (GO:0046929)2.06599903
155neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.06421630
156histone demethylation (GO:0016577)2.05248927
157nuclear pore organization (GO:0006999)2.05012590
158peptidyl-serine phosphorylation (GO:0018105)2.04708328
159peripheral nervous system axon ensheathment (GO:0032292)2.02968544
160myelination in peripheral nervous system (GO:0022011)2.02968544
161negative regulation of inclusion body assembly (GO:0090084)2.02112532
162labyrinthine layer development (GO:0060711)1.99574870
163adherens junction assembly (GO:0034333)1.99151543
164embryonic viscerocranium morphogenesis (GO:0048703)1.99139313
165Notch signaling involved in heart development (GO:0061314)1.99122601
166lymphangiogenesis (GO:0001946)1.98910865
167artery development (GO:0060840)1.98441438
168regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.96397919
169cellular response to growth hormone stimulus (GO:0071378)1.95194773
170cell-substrate adherens junction assembly (GO:0007045)1.95191875
171focal adhesion assembly (GO:0048041)1.95191875

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.22013932
2* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.88769305
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.20680022
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.88253557
5VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.61146981
6* RUNX_20019798_ChIP-Seq_JUKART_Human2.41515319
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.38916138
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.33467400
9FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.31431137
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.30298653
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.28290858
12GBX2_23144817_ChIP-Seq_PC3_Human2.18273764
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04880158
14KDM2B_26808549_Chip-Seq_SUP-B15_Human1.93083733
15IRF8_27001747_Chip-Seq_BMDM_Mouse1.90955766
16MYC_22102868_ChIP-Seq_BL_Human1.89658499
17DROSHA_22980978_ChIP-Seq_HELA_Human1.89538368
18KDM2B_26808549_Chip-Seq_DND41_Human1.86432884
19KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85328066
20TCF7_22412390_ChIP-Seq_EML_Mouse1.84639724
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.83511608
22EP300_21415370_ChIP-Seq_HL-1_Mouse1.83309964
23* SPI1_23127762_ChIP-Seq_K562_Human1.79991977
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.79344641
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71231056
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.66780072
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58462136
28GATA1_22025678_ChIP-Seq_K562_Human1.57947944
29TP53_16413492_ChIP-PET_HCT116_Human1.57130927
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.56322448
31SCL_19346495_ChIP-Seq_HPC-7_Human1.56034357
32DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.54420999
33SMAD4_21799915_ChIP-Seq_A2780_Human1.54265199
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52160066
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51611102
36* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50227811
37AHR_22903824_ChIP-Seq_MCF-7_Human1.50011567
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49430534
39VDR_21846776_ChIP-Seq_THP-1_Human1.48368956
40KDM2B_26808549_Chip-Seq_JURKAT_Human1.47276458
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45877572
42CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.44892049
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43653452
44SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42923316
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.42399889
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40772515
47MAF_26560356_Chip-Seq_TH1_Human1.38788128
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.37595622
49* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37297940
50* MYB_26560356_Chip-Seq_TH1_Human1.36431417
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.35395585
52* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.34316554
53* MYB_26560356_Chip-Seq_TH2_Human1.33360274
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33130267
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33127369
56* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32589045
57* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32589045
58* UTX_26944678_Chip-Seq_JUKART_Human1.31039075
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30699593
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.30615575
61* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.30232467
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29631676
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29121734
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28767635
65* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27550799
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26593929
67* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26406929
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26151394
69SMAD3_21741376_ChIP-Seq_HESCs_Human1.25158637
70CJUN_26792858_Chip-Seq_BT549_Human1.23507821
71IRF8_21731497_ChIP-ChIP_J774_Mouse1.23371311
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22850796
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21880264
74KDM2B_26808549_Chip-Seq_K562_Human1.19844908
75VDR_24787735_ChIP-Seq_THP-1_Human1.19209204
76AR_21572438_ChIP-Seq_LNCaP_Human1.18860642
77VDR_24763502_ChIP-Seq_THP-1_Human1.18834753
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.18653597
79GATA3_27048872_Chip-Seq_THYMUS_Human1.17527497
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.17137904
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.16373711
82* ISL1_27105846_Chip-Seq_CPCs_Mouse1.16034924
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15895024
84* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15838839
85PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.14828829
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14753721
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14315144
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12807089
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12568762
90* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11911252
91BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10312244
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10181306
93TAF15_26573619_Chip-Seq_HEK293_Human1.08671030
94STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07427869
95MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07278662
96PU_27001747_Chip-Seq_BMDM_Mouse1.06945309
97EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06782005
98* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06770306
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06456859
100RARB_27405468_Chip-Seq_BRAIN_Mouse1.06382126
101* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06318781
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05952815
103KDM2B_26808549_Chip-Seq_REH_Human1.05776203
104IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05568392
105NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04512701
106* FOXA2_19822575_ChIP-Seq_HepG2_Human1.04441732
107* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04420467
108RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03995752
109TP53_18474530_ChIP-ChIP_U2OS_Human1.03591597
110NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03307522
111FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03265488
112RXR_22108803_ChIP-Seq_LS180_Human1.03129400
113* NANOG_18555785_Chip-Seq_ESCs_Mouse1.01159132
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00983288
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00983288
116STAT3_23295773_ChIP-Seq_U87_Human1.00430478
117GATA1_19941826_ChIP-Seq_K562_Human0.99480408
118* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99333696
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98946666
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98557156
121CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98185311
122NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98162643
123TCF4_18268006_ChIP-ChIP_LS174T_Human0.97249678
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97212195
125* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97149995
126* TP63_23658742_ChIP-Seq_EP156T_Human0.96819265
127EZH2_22144423_ChIP-Seq_EOC_Human0.96749411
128FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96182096
129PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95890532
130SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95556920
131SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95556920
132FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94686575
133SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94643826
134* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93939216
135* AR_19668381_ChIP-Seq_PC3_Human0.92302636
136PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92273810
137* BRD4_25478319_ChIP-Seq_HGPS_Human0.91852522
138TBX20_22328084_ChIP-Seq_HEART_Mouse0.90856721
139TBX20_22080862_ChIP-Seq_HEART_Mouse0.90856721
140PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90578248
141ELK3_25401928_ChIP-Seq_HUVEC_Human0.90518390
142* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88411801
143RUNX1_22412390_ChIP-Seq_EML_Mouse0.87051665
144SOX2_21211035_ChIP-Seq_LN229_Gbm0.86882243
145* GATA2_19941826_ChIP-Seq_K562_Human0.86385337
146* TCF4_23295773_ChIP-Seq_U87_Human0.85263670

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation8.22850540
2MP0008057_abnormal_DNA_replication3.09266217
3MP0003300_gastrointestinal_ulcer2.97662094
4MP0010368_abnormal_lymphatic_system2.67338063
5MP0004510_myositis2.59789588
6MP0002166_altered_tumor_susceptibility2.54297869
7MP0003172_abnormal_lysosome_physiology2.53846133
8MP0003787_abnormal_imprinting2.47912486
9MP0008438_abnormal_cutaneous_collagen2.45219320
10MP0003045_fibrosis2.35481202
11MP0004272_abnormal_basement_membrane2.35402997
12MP0005275_abnormal_skin_tensile2.31628501
13MP0005409_darkened_coat_color2.31383852
14MP0003303_peritoneal_inflammation2.30099009
15MP0005174_abnormal_tail_pigmentation2.28899703
16MP0001800_abnormal_humoral_immune2.22327636
17MP0009278_abnormal_bone_marrow2.22169248
18MP0003763_abnormal_thymus_physiology2.17805806
19MP0001835_abnormal_antigen_presentation2.14800100
20MP0001790_abnormal_immune_system2.10451284
21MP0005387_immune_system_phenotype2.10451284
22MP0005076_abnormal_cell_differentiation1.95349261
23MP0001873_stomach_inflammation1.93795264
24MP0003183_abnormal_peptide_metabolism1.90252658
25MP0002006_tumorigenesis1.86633408
26MP0003091_abnormal_cell_migration1.84544336
27MP0000015_abnormal_ear_pigmentation1.83250326
28MP0002396_abnormal_hematopoietic_system1.83150851
29MP0003566_abnormal_cell_adhesion1.82541503
30MP0008961_abnormal_basal_metabolism1.80513572
31MP0004036_abnormal_muscle_relaxation1.79464896
32MP0000685_abnormal_immune_system1.79164127
33MP0002452_abnormal_antigen_presenting1.71324863
34MP0005671_abnormal_response_to1.67952987
35MP0002420_abnormal_adaptive_immunity1.53684539
36MP0001958_emphysema1.53419544
37MP0004808_abnormal_hematopoietic_stem1.52595047
38MP0002723_abnormal_immune_serum1.52535154
39MP0004859_abnormal_synaptic_plasticity1.51291572
40MP0001819_abnormal_immune_cell1.50427585
41MP0002398_abnormal_bone_marrow1.49902165
42MP0000371_diluted_coat_color1.46118706
43MP0000733_abnormal_muscle_development1.43637147
44MP0009780_abnormal_chondrocyte_physiolo1.41017337
45MP0004947_skin_inflammation1.39832466
46MP0005000_abnormal_immune_tolerance1.36189849
47MP0010352_gastrointestinal_tract_polyps1.35832472
48MP0000703_abnormal_thymus_morphology1.34283822
49MP0000428_abnormal_craniofacial_morphol1.31909251
50MP0003705_abnormal_hypodermis_morpholog1.29621327
51MP0000716_abnormal_immune_system1.26715519
52MP0002108_abnormal_muscle_morphology1.25632332
53MP0005464_abnormal_platelet_physiology1.23457162
54MP0002928_abnormal_bile_duct1.22729482
55MP0002133_abnormal_respiratory_system1.22528180
56MP0005388_respiratory_system_phenotype1.22528180
57MP0003632_abnormal_nervous_system1.21663680
58MP0010307_abnormal_tumor_latency1.21282894
59MP0004145_abnormal_muscle_electrophysio1.20940872
60MP0002009_preneoplasia1.18671663
61MP0001177_atelectasis1.17613968
62MP0006054_spinal_hemorrhage1.17609445
63MP0000689_abnormal_spleen_morphology1.16054754
64MP0002419_abnormal_innate_immunity1.14862830
65MP0005595_abnormal_vascular_smooth1.14244171
66MP0003890_abnormal_embryonic-extraembry1.13831057
67MP0005503_abnormal_tendon_morphology1.11445606
68MP0000465_gastrointestinal_hemorrhage1.11422706
69MP0000462_abnormal_digestive_system1.10004006
70MP0010630_abnormal_cardiac_muscle1.09719163
71* MP0005023_abnormal_wound_healing1.08783779
72MP0004130_abnormal_muscle_cell1.07551376
73MP0005058_abnormal_lysosome_morphology1.07456413
74MP0003279_aneurysm1.07189166
75MP0002722_abnormal_immune_system1.06783513
76MP0000749_muscle_degeneration1.06626714
77MP0003828_pulmonary_edema1.06207194
78MP0006138_congestive_heart_failure1.05947266
79MP0002332_abnormal_exercise_endurance1.05153380
80MP0003941_abnormal_skin_development1.04181845
81MP0004484_altered_response_of1.03871377
82MP0003866_abnormal_defecation1.03399978
83MP0005623_abnormal_meninges_morphology1.00867704
84MP0003868_abnormal_feces_composition0.99911190
85MP0001879_abnormal_lymphatic_vessel0.97606532
86MP0002405_respiratory_system_inflammati0.96895176
87* MP0002168_other_aberrant_phenotype0.95980005
88MP0003935_abnormal_craniofacial_develop0.94944932
89MP0000767_abnormal_smooth_muscle0.92551679
90MP0005397_hematopoietic_system_phenotyp0.92507178
91MP0001545_abnormal_hematopoietic_system0.92507178
92MP0003690_abnormal_glial_cell0.91236740
93MP0002429_abnormal_blood_cell0.90769412
94MP0002877_abnormal_melanocyte_morpholog0.90121972
95MP0005187_abnormal_penis_morphology0.89839315
96MP0003385_abnormal_body_wall0.89654508
97MP0008569_lethality_at_weaning0.89049945
98MP0002925_abnormal_cardiovascular_devel0.87724229
99MP0000534_abnormal_ureter_morphology0.86500708
100MP0001614_abnormal_blood_vessel0.86433969
101MP0003634_abnormal_glial_cell0.86356569
102MP0005620_abnormal_muscle_contractility0.85391905
103MP0001851_eye_inflammation0.85079590
104MP0001661_extended_life_span0.84409996
105MP0002127_abnormal_cardiovascular_syste0.84213265
106MP0003329_amyloid_beta_deposits0.83447491
107MP0004134_abnormal_chest_morphology0.83205161
108MP0004270_analgesia0.82749929
109MP0004883_abnormal_blood_vessel0.82270655
110MP0003448_altered_tumor_morphology0.82262581
111MP0000920_abnormal_myelination0.80903507
112MP0000759_abnormal_skeletal_muscle0.79871555
113MP0004087_abnormal_muscle_fiber0.79425683
114MP0005167_abnormal_blood-brain_barrier0.79345253
115MP0003984_embryonic_growth_retardation0.78450177
116MP0000432_abnormal_head_morphology0.78331558
117MP0002088_abnormal_embryonic_growth/wei0.77718478
118MP0003631_nervous_system_phenotype0.77677141
119MP0002896_abnormal_bone_mineralization0.77652038
120MP0005621_abnormal_cell_physiology0.77179500
121MP0000751_myopathy0.76755278
122MP0010234_abnormal_vibrissa_follicle0.76456506
123MP0010155_abnormal_intestine_physiology0.76432059
124MP0002095_abnormal_skin_pigmentation0.76297278
125MP0002086_abnormal_extraembryonic_tissu0.76148007
126MP0000013_abnormal_adipose_tissue0.75777261
127MP0009703_decreased_birth_body0.75404891
128MP0005025_abnormal_response_to0.74920897
129MP0004185_abnormal_adipocyte_glucose0.74165305
130MP0004084_abnormal_cardiac_muscle0.73478156
131MP0001784_abnormal_fluid_regulation0.73097658
132MP0002933_joint_inflammation0.73024801
133MP0001299_abnormal_eye_distance/0.72259766
134MP0002998_abnormal_bone_remodeling0.72207795
135MP0001175_abnormal_lung_morphology0.71987939
136MP0002269_muscular_atrophy0.71838650
137* MP0000778_abnormal_nervous_system0.71691024
138MP0009046_muscle_twitch0.71438689
139MP0003121_genomic_imprinting0.70308363
140MP0002909_abnormal_adrenal_gland0.68898165
141MP0002075_abnormal_coat/hair_pigmentati0.67509321
142MP0005670_abnormal_white_adipose0.67274258
143MP0000266_abnormal_heart_morphology0.67154236
144MP0003436_decreased_susceptibility_to0.65438828
145MP0003633_abnormal_nervous_system0.64492058
146MP0001915_intracranial_hemorrhage0.61976830
147MP0008770_decreased_survivor_rate0.61612272
148MP0002254_reproductive_system_inflammat0.60559297
149MP0001845_abnormal_inflammatory_respons0.60229090
150MP0000003_abnormal_adipose_tissue0.59208923
151MP0001853_heart_inflammation0.58091252
152MP0003115_abnormal_respiratory_system0.57396677
153MP0002128_abnormal_blood_circulation0.56660578
154MP0010678_abnormal_skin_adnexa0.55503329
155MP0000383_abnormal_hair_follicle0.53845993
156MP0003950_abnormal_plasma_membrane0.53561470

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.60703439
2Cerebral aneurysm (HP:0004944)3.54815290
3Macroorchidism (HP:0000053)3.20023781
4Aortic dissection (HP:0002647)3.12981090
5Absent frontal sinuses (HP:0002688)3.08751321
6Narrow palate (HP:0000189)3.00828739
7Overgrowth (HP:0001548)2.98299918
8Urethral obstruction (HP:0000796)2.87300574
9Hematochezia (HP:0002573)2.80280504
10Heterotopia (HP:0002282)2.75011745
11Aortic aneurysm (HP:0004942)2.72660492
12Colitis (HP:0002583)2.68631951
13Papillary thyroid carcinoma (HP:0002895)2.63084531
14Hemiplegia (HP:0002301)2.54946785
15Short chin (HP:0000331)2.44519017
16T lymphocytopenia (HP:0005403)2.39237577
17Frequent falls (HP:0002359)2.36767368
18Anal stenosis (HP:0002025)2.36681446
19Scanning speech (HP:0002168)2.33705707
20Autoimmune thrombocytopenia (HP:0001973)2.33064185
21Recurrent viral infections (HP:0004429)2.32283161
22Osteolytic defects of the phalanges of the hand (HP:0009771)2.30259198
23Osteolytic defects of the hand bones (HP:0009699)2.30259198
24Agammaglobulinemia (HP:0004432)2.26346438
25Atrophic scars (HP:0001075)2.25625182
26Lower limb amyotrophy (HP:0007210)2.21569352
27Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.19733997
28Abnormality of T cell number (HP:0011839)2.18779475
29Long eyelashes (HP:0000527)2.18181385
30Spondylolisthesis (HP:0003302)2.16210231
31Limited hip movement (HP:0008800)2.14906691
32Inflammation of the large intestine (HP:0002037)2.14732389
33Hyperacusis (HP:0010780)2.14646322
34Broad face (HP:0000283)2.14209009
35Recurrent fungal infections (HP:0002841)2.14031581
36Aqueductal stenosis (HP:0002410)2.13570653
37Genetic anticipation (HP:0003743)2.12759169
38Chronic mucocutaneous candidiasis (HP:0002728)2.11339144
39Recurrent cutaneous fungal infections (HP:0011370)2.11339144
40Recurrent abscess formation (HP:0002722)2.11121696
41Abnormality of the ischium (HP:0003174)2.09968403
42Acute myeloid leukemia (HP:0004808)2.07679145
43Distal lower limb amyotrophy (HP:0008944)2.06375535
44Recurrent bacterial skin infections (HP:0005406)2.06366512
45Mitral valve prolapse (HP:0001634)2.02852678
46Periodontitis (HP:0000704)2.01929851
47Protrusio acetabuli (HP:0003179)2.01648116
48Gastrointestinal inflammation (HP:0004386)1.99645195
49Vertebral arch anomaly (HP:0008438)1.99564622
50Abnormality of the radial head (HP:0003995)1.99453766
51Hypoplasia of the iris (HP:0007676)1.99303081
52Persistence of primary teeth (HP:0006335)1.95456992
53Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.93729959
54Short 4th metacarpal (HP:0010044)1.93690891
55Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.93690891
56Volvulus (HP:0002580)1.93352899
57Depressed nasal tip (HP:0000437)1.92651338
58Subacute progressive viral hepatitis (HP:0006572)1.92257866
59Stomatitis (HP:0010280)1.90983848
60Abnormal delayed hypersensitivity skin test (HP:0002963)1.89969465
61Lip pit (HP:0100267)1.86777600
62Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.85721683
63Spontaneous hematomas (HP:0007420)1.84645539
64Limited elbow extension (HP:0001377)1.82838279
65Abnormality of incisor morphology (HP:0011063)1.82198609
66Abnormality of the epiphyses of the hand (HP:0005924)1.80466820
67Hyporeflexia of lower limbs (HP:0002600)1.80302300
68Gastrointestinal stroma tumor (HP:0100723)1.80155062
69Aneurysm (HP:0002617)1.79785486
70Urinary bladder sphincter dysfunction (HP:0002839)1.79568292
71Prominent nose (HP:0000448)1.79458597
72Long toe (HP:0010511)1.79141748
73Wide anterior fontanel (HP:0000260)1.79074527
74Arterial tortuosity (HP:0005116)1.78628356
75Abnormality of the distal phalanx of the thumb (HP:0009617)1.78470660
76Trigonocephaly (HP:0000243)1.78377644
77Neonatal hypoglycemia (HP:0001998)1.78294412
78Shallow orbits (HP:0000586)1.77584378
79Sandal gap (HP:0001852)1.77575711
80Pulmonic stenosis (HP:0001642)1.77471190
81Abnormality of the frontal sinuses (HP:0002687)1.76806837
82Cubitus valgus (HP:0002967)1.76624878
83Thick nail (HP:0001805)1.75308537
84Elfin facies (HP:0004428)1.75278797
85Interstitial pulmonary disease (HP:0006530)1.75025116
86Obsessive-compulsive behavior (HP:0000722)1.74867742
87Wormian bones (HP:0002645)1.74589451
88Increased density of long bones (HP:0006392)1.74338472
89Submucous cleft hard palate (HP:0000176)1.73679415
90Broad metatarsal (HP:0001783)1.73614082
91Emphysema (HP:0002097)1.73206745
92Bicuspid aortic valve (HP:0001647)1.72434436
93Laryngomalacia (HP:0001601)1.71978948
94Hyperventilation (HP:0002883)1.71811992
95Restrictive lung disease (HP:0002091)1.71767894
96Hypoplastic ischia (HP:0003175)1.71639907
97Mask-like facies (HP:0000298)1.71630656
98Intestinal fistula (HP:0100819)1.70958040
99Panhypogammaglobulinemia (HP:0003139)1.70115930
100Large earlobe (HP:0009748)1.69484755
101Dislocated radial head (HP:0003083)1.69100924
102Thyroiditis (HP:0100646)1.68745550
103Pointed chin (HP:0000307)1.68572568
104Syringomyelia (HP:0003396)1.68033018
105Spinal cord lesions (HP:0100561)1.68033018
106Recurrent bronchitis (HP:0002837)1.67765945
107Difficulty running (HP:0009046)1.67693401
108Truncal obesity (HP:0001956)1.67441998
109Conjunctival telangiectasia (HP:0000524)1.67351810
110Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.66727671
111Neonatal short-limb short stature (HP:0008921)1.65920266
112Ureteral obstruction (HP:0006000)1.65494479
113Abnormality of the nasal septum (HP:0000419)1.65245621
114Dilatation of the ascending aorta (HP:0005111)1.64666262
115Progressive hearing impairment (HP:0001730)1.64128340
116Thoracolumbar scoliosis (HP:0002944)1.63228690
117Ureteral stenosis (HP:0000071)1.63191074
118Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.63141340
119Cutaneous finger syndactyly (HP:0010554)1.63084642
120Chronic diarrhea (HP:0002028)1.62599166
121Dysmetric saccades (HP:0000641)1.62581674
122Low anterior hairline (HP:0000294)1.61833775
123Thick eyebrow (HP:0000574)1.60657950
124Mitral regurgitation (HP:0001653)1.60577528
125Broad ribs (HP:0000885)1.60299086
126Abnormality of the astrocytes (HP:0100707)1.59874325
127Astrocytoma (HP:0009592)1.59874325
128Urinary urgency (HP:0000012)1.59375487
129Increased CSF protein (HP:0002922)1.58983677
130Drooling (HP:0002307)1.58910520
131Excessive salivation (HP:0003781)1.58910520
132Disproportionate tall stature (HP:0001519)1.58363709
133Tapered finger (HP:0001182)1.58325837
134Abnormality of binocular vision (HP:0011514)1.58051800
135Diplopia (HP:0000651)1.58051800
136Widely spaced teeth (HP:0000687)1.58016832
137Deeply set eye (HP:0000490)1.57950794
138Hypoplasia of the maxilla (HP:0000327)1.57941820
139Verrucae (HP:0200043)1.57467545
140Papilloma (HP:0012740)1.57467545
141Ulnar bowing (HP:0003031)1.57306478
142Oligodontia (HP:0000677)1.57199178
143Vascular tortuosity (HP:0004948)1.57119905
144Ankyloglossia (HP:0010296)1.56725982
145Progressive sensorineural hearing impairment (HP:0000408)1.56721373
146Protruding tongue (HP:0010808)1.56698330
147Skull defect (HP:0001362)1.56322144
148Abnormality of oral frenula (HP:0000190)1.53515129
149Abnormal glucose tolerance (HP:0001952)1.51132889
150Blue irides (HP:0000635)1.49693361
151Vitreoretinal degeneration (HP:0000655)1.49680279
152Mild short stature (HP:0003502)1.48918351
153Bronchomalacia (HP:0002780)1.48048355
154Obstructive sleep apnea (HP:0002870)1.46747775
155Joint laxity (HP:0001388)1.46558104
156Relative macrocephaly (HP:0004482)1.46214355
157Subaortic stenosis (HP:0001682)1.45724898
158Abnormality of the left ventricular outflow tract (HP:0011103)1.45724898
159Tracheomalacia (HP:0002779)1.45637853
160Glucose intolerance (HP:0000833)1.45571364
161Hepatoblastoma (HP:0002884)1.44334676
162Decreased lacrimation (HP:0000633)1.44159741
163Germ cell neoplasia (HP:0100728)1.43992802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.32464622
2CAMK1G3.02282200
3MAP4K12.91139946
4SIK22.73674293
5CAMK1D2.73080426
6AKT32.50422026
7MAP3K132.46067009
8TTN2.36755349
9JAK12.13020243
10FRK1.95904120
11BRD41.94674624
12FGFR31.84661404
13MAP3K101.78167911
14TYK21.78099462
15TGFBR21.74402566
16RIPK11.65650596
17ITK1.65475851
18NLK1.58137017
19JAK31.54345939
20SGK31.53388626
21RIPK41.50124643
22TIE11.44205417
23HCK1.41825940
24MAP3K141.41560470
25TXK1.40443789
26FGFR41.39549363
27SGK21.35687768
28STK101.35613136
29PRKCH1.31539534
30CASK1.30287355
31FGFR21.28909793
32PIK3CG1.24411389
33EPHA31.22453427
34MAP3K71.21582430
35PDGFRB1.21358643
36PTK61.19683937
37NEK91.18136510
38OBSCN1.17407701
39MARK21.15491422
40MAP3K61.15259316
41KIT1.15228781
42CDC42BPA1.14190363
43SIK11.13971115
44DMPK1.12910877
45EEF2K1.11930992
46CSF1R1.11500781
47MARK31.08420302
48PKN21.08066385
49WNK11.06941719
50IKBKE1.03626718
51FES1.02667694
52NTRK21.02517062
53MET1.02421464
54MTOR1.02318893
55MAPK71.01254657
56MAP3K20.98001159
57CSK0.97126036
58LCK0.94475363
59NTRK30.93525936
60PDGFRA0.93262048
61GRK60.92989423
62MAPK120.89087554
63MAP3K90.88394820
64NTRK10.87833017
65CDK60.82767908
66FER0.81408665
67STK380.80503425
68SGK10.79115391
69PIK3CA0.78708435
70STK38L0.76945653
71TRIB30.76771225
72ZAP700.75351903
73SYK0.74727547
74PNCK0.74076386
75JAK20.73722610
76TYRO30.72797733
77PTK2B0.72366896
78BLK0.71942753
79KSR10.70851532
80PDK10.70204686
81MYLK0.69871535
82PRKCQ0.69765779
83CHUK0.69108263
84ALK0.69100464
85CAMK40.68986512
86TNIK0.68911838
87PAK20.68608783
88STK110.67277874
89ICK0.67189265
90TAOK30.65583889
91FGFR10.64951296
92HIPK20.64772005
93TRPM70.64595864
94LATS10.64046129
95ERBB20.63698884
96PRKD20.63012315
97SGK2230.62137366
98SGK4940.62137366
99INSRR0.61608196
100EGFR0.61394131
101CDK90.61201451
102MELK0.60211672
103MAPK100.60100715
104DAPK20.59694593
105PRPF4B0.59345723
106FLT30.58159304
107PRKD10.58144780
108FYN0.57682183
109BTK0.56952523
110RET0.56256157
111MKNK20.53556152
112TEC0.52803709
113NEK60.51398803
114CAMKK20.50833006
115INSR0.49975104
116PRKAA20.49655094
117KSR20.49311328
118PKN10.49269867
119RPS6KA20.48696524
120IRAK30.47699434
121EPHB10.47697775
122PAK30.47342890
123MAPK80.46888892
124CAMKK10.46469739
125EPHA40.45842390
126YES10.45818648
127ROCK10.45802420
128NUAK10.45730567
129PTK20.45194180
130LRRK20.44015275
131IKBKB0.43984252
132PRKDC0.43784778
133SCYL20.43391767
134MARK10.42869615
135CAMK10.41322785
136ROCK20.40718489
137SRC0.40319090
138MAP3K40.40242100
139BMX0.38195262

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.15912615
2ECM-receptor interaction_Homo sapiens_hsa045121.73639482
3Phosphatidylinositol signaling system_Homo sapiens_hsa040701.70410061
4Primary immunodeficiency_Homo sapiens_hsa053401.68320299
5T cell receptor signaling pathway_Homo sapiens_hsa046601.62125049
6Osteoclast differentiation_Homo sapiens_hsa043801.59093881
7Type II diabetes mellitus_Homo sapiens_hsa049301.58729758
8Lysine degradation_Homo sapiens_hsa003101.51523542
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.42433928
10Dorso-ventral axis formation_Homo sapiens_hsa043201.35864994
11mTOR signaling pathway_Homo sapiens_hsa041501.34175545
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.32148219
13Chronic myeloid leukemia_Homo sapiens_hsa052201.30493262
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27577118
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27475541
16Thyroid hormone signaling pathway_Homo sapiens_hsa049191.24486518
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22483529
18Vascular smooth muscle contraction_Homo sapiens_hsa042701.17606940
19Platelet activation_Homo sapiens_hsa046111.15636254
20Dilated cardiomyopathy_Homo sapiens_hsa054141.14205453
21Viral myocarditis_Homo sapiens_hsa054161.13196455
22Amoebiasis_Homo sapiens_hsa051461.13170153
23Neurotrophin signaling pathway_Homo sapiens_hsa047221.12112490
24Inositol phosphate metabolism_Homo sapiens_hsa005621.11499713
25Chemokine signaling pathway_Homo sapiens_hsa040621.11101959
26Pancreatic cancer_Homo sapiens_hsa052121.10487660
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09905637
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.07670014
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06399956
30Phospholipase D signaling pathway_Homo sapiens_hsa040721.05784900
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05647616
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04351070
33Glioma_Homo sapiens_hsa052141.03659347
34Hematopoietic cell lineage_Homo sapiens_hsa046401.03579111
35Toxoplasmosis_Homo sapiens_hsa051451.03443587
36Measles_Homo sapiens_hsa051621.02052732
37Proteoglycans in cancer_Homo sapiens_hsa052051.01387393
38Circadian rhythm_Homo sapiens_hsa047100.99957308
39Non-small cell lung cancer_Homo sapiens_hsa052230.99697953
40Long-term potentiation_Homo sapiens_hsa047200.99167349
41Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98786238
42Insulin resistance_Homo sapiens_hsa049310.98752777
43Gastric acid secretion_Homo sapiens_hsa049710.98458787
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97978110
45Leishmaniasis_Homo sapiens_hsa051400.96799023
46Colorectal cancer_Homo sapiens_hsa052100.95579756
47Small cell lung cancer_Homo sapiens_hsa052220.95362483
48Renin secretion_Homo sapiens_hsa049240.94983309
49Endometrial cancer_Homo sapiens_hsa052130.94952841
50Salivary secretion_Homo sapiens_hsa049700.94946118
51Focal adhesion_Homo sapiens_hsa045100.94401552
52GnRH signaling pathway_Homo sapiens_hsa049120.93339765
53MicroRNAs in cancer_Homo sapiens_hsa052060.92741376
54Notch signaling pathway_Homo sapiens_hsa043300.92373746
55Tight junction_Homo sapiens_hsa045300.91683192
56Estrogen signaling pathway_Homo sapiens_hsa049150.91470352
57Choline metabolism in cancer_Homo sapiens_hsa052310.91152848
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90540724
59Oxytocin signaling pathway_Homo sapiens_hsa049210.90163767
60Acute myeloid leukemia_Homo sapiens_hsa052210.90029055
61Adherens junction_Homo sapiens_hsa045200.89999529
62Olfactory transduction_Homo sapiens_hsa047400.89663795
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88953310
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.88917501
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88500453
66Influenza A_Homo sapiens_hsa051640.88495944
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88410845
68Long-term depression_Homo sapiens_hsa047300.88349756
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88345475
70Axon guidance_Homo sapiens_hsa043600.88239037
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88021716
72Circadian entrainment_Homo sapiens_hsa047130.86722221
73Gap junction_Homo sapiens_hsa045400.86485682
74Rap1 signaling pathway_Homo sapiens_hsa040150.86420221
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86224656
76Cholinergic synapse_Homo sapiens_hsa047250.86139852
77MAPK signaling pathway_Homo sapiens_hsa040100.85630732
78Morphine addiction_Homo sapiens_hsa050320.85250773
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85131434
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85118083
81TNF signaling pathway_Homo sapiens_hsa046680.84971408
82Pathways in cancer_Homo sapiens_hsa052000.84429139
83Renal cell carcinoma_Homo sapiens_hsa052110.84294525
84Ras signaling pathway_Homo sapiens_hsa040140.82875518
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.82594484
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82415322
87Hepatitis B_Homo sapiens_hsa051610.81693970
88ErbB signaling pathway_Homo sapiens_hsa040120.79742864
89VEGF signaling pathway_Homo sapiens_hsa043700.79566038
90Insulin secretion_Homo sapiens_hsa049110.79192131
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79062870
92TGF-beta signaling pathway_Homo sapiens_hsa043500.78123934
93FoxO signaling pathway_Homo sapiens_hsa040680.78061905
94Glutamatergic synapse_Homo sapiens_hsa047240.78030686
95cAMP signaling pathway_Homo sapiens_hsa040240.77642825
96Thyroid hormone synthesis_Homo sapiens_hsa049180.77541009
97Tuberculosis_Homo sapiens_hsa051520.76725100
98Melanoma_Homo sapiens_hsa052180.76053943
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75773702
100Thyroid cancer_Homo sapiens_hsa052160.74623983
101Prolactin signaling pathway_Homo sapiens_hsa049170.73867698
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70421758
103Prostate cancer_Homo sapiens_hsa052150.70383358
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70208805
105Insulin signaling pathway_Homo sapiens_hsa049100.69834534
106Calcium signaling pathway_Homo sapiens_hsa040200.69445129
107Hippo signaling pathway_Homo sapiens_hsa043900.69332209
108Apoptosis_Homo sapiens_hsa042100.68939353
109HTLV-I infection_Homo sapiens_hsa051660.68296428
110Melanogenesis_Homo sapiens_hsa049160.68079413
111Endocytosis_Homo sapiens_hsa041440.67429727
112Hepatitis C_Homo sapiens_hsa051600.67307761
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67178206
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66977797
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66387333
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64404992
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64185530
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.63596674
119Pancreatic secretion_Homo sapiens_hsa049720.62828235
120HIF-1 signaling pathway_Homo sapiens_hsa040660.62524339
121Protein digestion and absorption_Homo sapiens_hsa049740.62213014
122Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60793316
123ABC transporters_Homo sapiens_hsa020100.60203399
124Wnt signaling pathway_Homo sapiens_hsa043100.57573212
125Taste transduction_Homo sapiens_hsa047420.56660359

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