MACROD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)5.97467417
2tricarboxylic acid cycle (GO:0006099)5.75231826
3actin-myosin filament sliding (GO:0033275)5.59455268
4muscle filament sliding (GO:0030049)5.59455268
5carnitine shuttle (GO:0006853)5.53977773
6lysine metabolic process (GO:0006553)5.30032432
7lysine catabolic process (GO:0006554)5.30032432
8skeletal muscle adaptation (GO:0043501)5.26425753
92-oxoglutarate metabolic process (GO:0006103)5.24125283
10regulation of skeletal muscle contraction (GO:0014819)5.22026867
11fatty acid transmembrane transport (GO:1902001)5.20039542
12skeletal muscle fiber development (GO:0048741)5.00223268
13response to muscle activity (GO:0014850)4.98789004
14cardiac myofibril assembly (GO:0055003)4.89199991
15myofibril assembly (GO:0030239)4.89111654
16regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.78680171
17fatty acid beta-oxidation (GO:0006635)4.77842977
18negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.74780267
19aspartate family amino acid catabolic process (GO:0009068)4.68604680
20positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.61980741
21gluconeogenesis (GO:0006094)4.57345952
22actin-mediated cell contraction (GO:0070252)4.48972929
23regulation of sequestering of triglyceride (GO:0010889)4.48153716
24valine metabolic process (GO:0006573)4.33092337
25muscle contraction (GO:0006936)4.33037295
26myotube cell development (GO:0014904)4.30702776
27NADH metabolic process (GO:0006734)4.29844637
28carnitine transmembrane transport (GO:1902603)4.29676376
29regulation of acyl-CoA biosynthetic process (GO:0050812)4.29332525
30creatine metabolic process (GO:0006600)4.29071267
31fatty acid catabolic process (GO:0009062)4.23946465
32cardiac muscle contraction (GO:0060048)4.23204058
33negative regulation of potassium ion transmembrane transport (GO:1901380)4.22803633
34fatty acid oxidation (GO:0019395)4.21220520
35plasma membrane repair (GO:0001778)4.20634323
36hexose biosynthetic process (GO:0019319)4.16463192
37negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.14203438
38short-chain fatty acid metabolic process (GO:0046459)4.13955162
39response to inactivity (GO:0014854)4.13901225
40branched-chain amino acid catabolic process (GO:0009083)4.12336321
41erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.12050294
42L-phenylalanine metabolic process (GO:0006558)4.12050294
43lipid oxidation (GO:0034440)4.11972150
44carnitine transport (GO:0015879)4.10493999
45amino-acid betaine transport (GO:0015838)4.10493999
46regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.10220419
47oxaloacetate metabolic process (GO:0006107)4.08822078
48L-phenylalanine catabolic process (GO:0006559)4.04208714
49erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.04208714
50cellular ketone body metabolic process (GO:0046950)4.03731871
51glyoxylate metabolic process (GO:0046487)4.03508679
52fructose metabolic process (GO:0006000)4.03282660
53striated muscle atrophy (GO:0014891)4.01990459
54sarcoplasmic reticulum calcium ion transport (GO:0070296)4.01610634
55regulation of fatty acid oxidation (GO:0046320)4.00474202
56negative regulation of cell size (GO:0045792)3.99880918
57fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.99586663
58acetyl-CoA metabolic process (GO:0006084)3.98810747
59succinate metabolic process (GO:0006105)3.96117961
60tricarboxylic acid metabolic process (GO:0072350)3.95898582
61branched-chain amino acid metabolic process (GO:0009081)3.92693925
62regulation of coenzyme metabolic process (GO:0051196)3.88257270
63regulation of cofactor metabolic process (GO:0051193)3.88257270
64monosaccharide biosynthetic process (GO:0046364)3.85983729
65carnitine metabolic process (GO:0009437)3.83417060
66striated muscle contraction (GO:0006941)3.82508702
67monocarboxylic acid catabolic process (GO:0072329)3.82125675
68muscle system process (GO:0003012)3.82042907
69cellular polysaccharide catabolic process (GO:0044247)3.79519591
70amino-acid betaine metabolic process (GO:0006577)3.78426989
71kynurenine metabolic process (GO:0070189)3.77165024
72cardiac muscle cell development (GO:0055013)3.72974135
73muscle cell fate commitment (GO:0042693)3.70986981
74skeletal muscle contraction (GO:0003009)3.69367225
75muscle atrophy (GO:0014889)3.67267587
76bundle of His cell to Purkinje myocyte communication (GO:0086069)3.64531906
77regulation of triglyceride catabolic process (GO:0010896)3.63638905
78oxidative phosphorylation (GO:0006119)3.63165200
79regulation of actin filament-based movement (GO:1903115)3.62938154
80striated muscle adaptation (GO:0014888)3.60430958
81muscle organ morphogenesis (GO:0048644)3.60243014
82actomyosin structure organization (GO:0031032)3.59670105
83biotin metabolic process (GO:0006768)3.58775401
84regulation of relaxation of muscle (GO:1901077)3.58267892
85ethanol oxidation (GO:0006069)3.55013310
86regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.53839923
87positive regulation of fatty acid oxidation (GO:0046321)3.51249447
88regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.49999422
89response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.49221406
90positive regulation of myotube differentiation (GO:0010831)3.48216310
91positive regulation of fatty acid beta-oxidation (GO:0032000)3.47679913
92cardiac cell development (GO:0055006)3.46476452
93glycogen catabolic process (GO:0005980)3.46081328
94ketone body metabolic process (GO:1902224)3.45993658
95ventricular cardiac muscle cell action potential (GO:0086005)3.45954157
96proline biosynthetic process (GO:0006561)3.45149041
97alpha-linolenic acid metabolic process (GO:0036109)3.43894945
98respiratory electron transport chain (GO:0022904)3.42513842
99triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.41299282
100aromatic amino acid family catabolic process (GO:0009074)3.41163511
101mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.39582598
102quaternary ammonium group transport (GO:0015697)3.38688522
103muscle cell cellular homeostasis (GO:0046716)3.37584346
104mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.37249469
105regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.35658561
106ubiquinone biosynthetic process (GO:0006744)3.34538376
107polysaccharide catabolic process (GO:0000272)3.34084649
108electron transport chain (GO:0022900)3.32936077
109regulation of sulfur metabolic process (GO:0042762)3.32095529
110heart contraction (GO:0060047)3.31659547
111heart process (GO:0003015)3.31659547
112skeletal muscle tissue development (GO:0007519)3.30843678
113positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.30776982
114glycogen metabolic process (GO:0005977)3.29906474
115actin filament-based movement (GO:0030048)3.28316943
116glucan catabolic process (GO:0009251)3.26757517
117muscle fiber development (GO:0048747)3.26461239
118cardiac muscle hypertrophy (GO:0003300)3.25684694
119adult heart development (GO:0007512)3.25486270
120glycolytic process (GO:0006096)3.23542262
121glucan metabolic process (GO:0044042)3.20021752
122cellular glucan metabolic process (GO:0006073)3.20021752
123cardiac muscle tissue morphogenesis (GO:0055008)3.19946077
124IMP metabolic process (GO:0046040)3.19353435
125heart trabecula formation (GO:0060347)3.19200936
126muscle tissue morphogenesis (GO:0060415)3.18021337
127cysteine metabolic process (GO:0006534)3.17079739
128carboxylic acid catabolic process (GO:0046395)3.14967029
129organic acid catabolic process (GO:0016054)3.14967029
130striated muscle hypertrophy (GO:0014897)3.13702228
131glycogen biosynthetic process (GO:0005978)3.13680756
132glucan biosynthetic process (GO:0009250)3.13680756
133regulation of cell communication by electrical coupling (GO:0010649)3.13678376
134muscle adaptation (GO:0043500)3.12613144
135negative regulation of necroptotic process (GO:0060546)3.11111574
136glucose metabolic process (GO:0006006)2.96782992
137muscle hypertrophy (GO:0014896)2.93801515
138positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.90784781
139muscle organ development (GO:0007517)2.88787195
140muscle structure development (GO:0061061)2.84215088
141ubiquinone metabolic process (GO:0006743)2.83031373
142AMP metabolic process (GO:0046033)2.82887958
143purine nucleotide salvage (GO:0032261)2.80379815
144focal adhesion assembly (GO:0048041)2.74539977
145cell-substrate adherens junction assembly (GO:0007045)2.74539977
146quinone biosynthetic process (GO:1901663)2.74519934
147mitochondrial fusion (GO:0008053)2.72853654
148skeletal muscle tissue regeneration (GO:0043403)2.72362019
149regulation of the force of heart contraction (GO:0002026)2.67974647
150peptidyl-arginine omega-N-methylation (GO:0035247)2.67044226
151striated muscle cell development (GO:0055002)2.66474291
152galactose catabolic process (GO:0019388)2.65898561
153regulation of striated muscle contraction (GO:0006942)2.62906256
154nucleotide salvage (GO:0043173)2.59657413
155deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.59330276
156cellular carbohydrate biosynthetic process (GO:0034637)2.57299973

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.89610569
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.75635469
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.40284636
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.03374663
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.19066445
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.17633859
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.57045310
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.20584350
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.97539481
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.91765587
11ZNF263_19887448_ChIP-Seq_K562_Human2.84585292
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.71488005
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.61144617
14TBX20_22080862_ChIP-Seq_HEART_Mouse2.35776026
15TBX20_22328084_ChIP-Seq_HEART_Mouse2.35776026
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28951542
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24614109
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.19603126
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.15000413
20MYC_22102868_ChIP-Seq_BL_Human2.03740669
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92254462
22ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.89188330
23E2F7_22180533_ChIP-Seq_HELA_Human1.84091159
24DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.83738606
25CLOCK_20551151_ChIP-Seq_293T_Human1.79679117
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.78550369
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.76802370
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.75557225
29GATA1_22025678_ChIP-Seq_K562_Human1.74386900
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.73571058
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.72105092
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70540998
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.67343910
34CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.66403735
35XRN2_22483619_ChIP-Seq_HELA_Human1.63583117
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.63195755
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.59664967
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.59327929
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.58353282
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54768926
41TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.53828913
42CTCF_27219007_Chip-Seq_ERYTHROID_Human1.52432699
43PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.48653824
44LXR_22292898_ChIP-Seq_THP-1_Human1.45072176
45HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.44894134
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42934682
47SMC4_20622854_ChIP-Seq_HELA_Human1.40852130
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.37563834
49CREB1_26743006_Chip-Seq_LNCaP_Human1.33983290
50EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33569989
51ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33557454
52MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.32154135
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.28639892
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28474070
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28315766
56GATA4_21415370_ChIP-Seq_HL-1_Mouse1.27860466
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27043265
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26934949
59NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.25962800
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25229156
61* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.24741516
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24628903
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24093928
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21457680
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20697009
66* FOXP1_21924763_ChIP-Seq_HESCs_Human1.20435380
67SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.17229222
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16679976
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16407773
70TP63_17297297_ChIP-ChIP_HaCaT_Human1.15884354
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14065351
72SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14037484
73KDM2B_26808549_Chip-Seq_K562_Human1.12752481
74CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12320203
75* FOXA2_19822575_ChIP-Seq_HepG2_Human1.11939863
76CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11757879
77BCOR_27268052_Chip-Seq_Bcells_Human1.11652624
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.10834515
79NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10459096
80NCOR1_26117541_ChIP-Seq_K562_Human1.10303191
81* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10136053
82P68_20966046_ChIP-Seq_HELA_Human1.10074158
83RACK7_27058665_Chip-Seq_MCF-7_Human1.09620417
84* GATA1_19941827_ChIP-Seq_MEL_Mouse1.09378793
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09062857
86EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08821994
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08771085
88NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08731769
89DCP1A_22483619_ChIP-Seq_HELA_Human1.08034219
90* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08020605
91STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.07947607
92CTCF_21964334_ChIP-Seq_BJAB-B_Human1.07946355
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07850043
94* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.07195746
95* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07160658
96ETS1_20019798_ChIP-Seq_JURKAT_Human1.06831217
97BCL6_27268052_Chip-Seq_Bcells_Human1.06456775
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06347303
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06195940
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05573436
101RUNX1_27514584_Chip-Seq_MCF-7_Human1.05392191
102CTCF_21964334_Chip-Seq_Bcells_Human1.03134024
103SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02542600
104NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01314080
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00731247
106CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00622105
107GATA1_19941826_ChIP-Seq_K562_Human1.00166083
108ATF3_27146783_Chip-Seq_COLON_Human0.94486379
109CTCF_27219007_Chip-Seq_Bcells_Human0.92755729
110SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92658239
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91986649
112* ELK3_25401928_ChIP-Seq_HUVEC_Human0.89538639
113* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89475720
114GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88059376
115ELF1_20517297_ChIP-Seq_JURKAT_Human0.86384060
116VDR_21846776_ChIP-Seq_THP-1_Human0.84178500
117HNF4A_19822575_ChIP-Seq_HepG2_Human0.83370579
118SCL_19346495_ChIP-Seq_HPC-7_Human0.83320382
119GATA2_19941826_ChIP-Seq_K562_Human0.83051925
120CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82852592
121* SPI1_20517297_ChIP-Seq_HL60_Human0.82820510
122RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.82597269
123* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82543295
124* TP63_22573176_ChIP-Seq_HFKS_Human0.82192507
125GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81942202
126SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81814163
127E2F1_20622854_ChIP-Seq_HELA_Human0.81542629
128* OCT4_20526341_ChIP-Seq_ESCs_Human0.80865051
129TCF7_22412390_ChIP-Seq_EML_Mouse0.80500836
130* KDM2B_26808549_Chip-Seq_DND41_Human0.80418892
131CEBPB_22108803_ChIP-Seq_LS180_Human0.79961059
132BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.79930788
133* SA1_27219007_Chip-Seq_Bcells_Human0.79535250
134YY1_22570637_ChIP-Seq_MALME-3M_Human0.78078564
135SMC3_22415368_ChIP-Seq_MEFs_Mouse0.78046333
136SRF_21415370_ChIP-Seq_HL-1_Mouse0.77669025
137AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76732943
138* TET1_21451524_ChIP-Seq_MESCs_Mouse0.76078831
139KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76033091
140P63_26484246_Chip-Seq_KERATINOCYTES_Human0.75263099
141RXRA_24833708_ChIP-Seq_LIVER_Mouse0.75116200
142CTCF_26484167_Chip-Seq_Bcells_Mouse0.73894957
143ESR1_21235772_ChIP-Seq_MCF-7_Human0.73302635
144CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73106949
145NANOG_20526341_ChIP-Seq_ESCs_Human0.72967773
146PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72958238
147SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72900890
148MAF_26560356_Chip-Seq_TH1_Human0.72811880
149* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.72328906
150BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.71188191
151SA1_27219007_Chip-Seq_ERYTHROID_Human0.70866713

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.54129727
2MP0003646_muscle_fatigue5.35751027
3MP0000751_myopathy4.23294820
4MP0004084_abnormal_cardiac_muscle3.65206768
5MP0000749_muscle_degeneration3.64224953
6MP0002139_abnormal_hepatobiliary_system3.60805319
7MP0004036_abnormal_muscle_relaxation3.43616331
8MP0005360_urolithiasis3.20859530
9MP0004215_abnormal_myocardial_fiber3.15574741
10MP0005330_cardiomyopathy3.07440433
11MP0003806_abnormal_nucleotide_metabolis3.06585196
12MP0005085_abnormal_gallbladder_physiolo2.99352659
13MP0004130_abnormal_muscle_cell2.95471030
14MP0005365_abnormal_bile_salt2.90833963
15MP0004087_abnormal_muscle_fiber2.64248699
16MP0004145_abnormal_muscle_electrophysio2.55677123
17MP0006036_abnormal_mitochondrial_physio2.42906673
18MP0002269_muscular_atrophy2.31930353
19MP0002106_abnormal_muscle_physiology2.29109980
20MP0000747_muscle_weakness2.26644105
21MP0000750_abnormal_muscle_regeneration2.21930015
22MP0005620_abnormal_muscle_contractility2.18521448
23MP0008875_abnormal_xenobiotic_pharmacok2.17879259
24MP0002972_abnormal_cardiac_muscle2.11201856
25MP0005083_abnormal_biliary_tract1.96790917
26MP0009840_abnormal_foam_cell1.93994479
27MP0000759_abnormal_skeletal_muscle1.91713789
28MP0010630_abnormal_cardiac_muscle1.89605197
29MP0001544_abnormal_cardiovascular_syste1.88816901
30MP0005385_cardiovascular_system_phenoty1.88816901
31MP0003137_abnormal_impulse_conducting1.88777593
32MP0008775_abnormal_heart_ventricle1.86694343
33MP0005369_muscle_phenotype1.82259746
34MP0003252_abnormal_bile_duct1.78625629
35MP0005666_abnormal_adipose_tissue1.77751097
36MP0005670_abnormal_white_adipose1.73011281
37MP0010329_abnormal_lipoprotein_level1.69392236
38MP0005332_abnormal_amino_acid1.63015670
39MP0003195_calcinosis1.61633920
40MP0006138_congestive_heart_failure1.57914472
41MP0003221_abnormal_cardiomyocyte_apopto1.56991924
42MP0004484_altered_response_of1.56883500
43MP0005319_abnormal_enzyme/_coenzyme1.45629568
44MP0001661_extended_life_span1.43675405
45MP0002118_abnormal_lipid_homeostasis1.37314004
46MP0001666_abnormal_nutrient_absorption1.34931200
47MP0004185_abnormal_adipocyte_glucose1.30292353
48MP0004233_abnormal_muscle_weight1.27815883
49MP0006035_abnormal_mitochondrial_morpho1.27387666
50MP0002332_abnormal_exercise_endurance1.27129195
51MP0004085_abnormal_heartbeat1.23529072
52MP0003656_abnormal_erythrocyte_physiolo1.22337063
53MP0005584_abnormal_enzyme/coenzyme_acti1.20974676
54MP0002971_abnormal_brown_adipose1.19628469
55MP0003191_abnormal_cellular_cholesterol1.18974210
56MP0000609_abnormal_liver_physiology1.17342710
57MP0003828_pulmonary_edema1.16680503
58MP0003123_paternal_imprinting1.16507834
59MP0004858_abnormal_nervous_system1.15419011
60MP0005375_adipose_tissue_phenotype1.14961551
61MP0005266_abnormal_metabolism1.13930647
62MP0005076_abnormal_cell_differentiation1.10166416
63MP0005451_abnormal_body_composition1.10016929
64MP0010030_abnormal_orbit_morphology1.09354378
65MP0000343_altered_response_to1.06396864
66MP0003705_abnormal_hypodermis_morpholog1.06074724
67MP0002249_abnormal_larynx_morphology1.04921260
68MP0001346_abnormal_lacrimal_gland1.01378421
69MP0004510_myositis0.97040302
70MP0004043_abnormal_pH_regulation0.96634005
71MP0002078_abnormal_glucose_homeostasis0.95442405
72MP0000678_abnormal_parathyroid_gland0.95405971
73MP0009643_abnormal_urine_homeostasis0.94602579
74MP0009672_abnormal_birth_weight0.93468437
75MP0002127_abnormal_cardiovascular_syste0.91359036
76MP0010368_abnormal_lymphatic_system0.86241745
77MP0010234_abnormal_vibrissa_follicle0.86090111
78MP0003186_abnormal_redox_activity0.85584071
79MP0000230_abnormal_systemic_arterial0.82080604
80MP0005165_increased_susceptibility_to0.82025033
81MP0004147_increased_porphyrin_level0.79385857
82MP0005535_abnormal_body_temperature0.78728777
83MP0002877_abnormal_melanocyte_morpholog0.77407058
84MP0005334_abnormal_fat_pad0.77194332
85MP0005058_abnormal_lysosome_morphology0.75099379
86MP0002234_abnormal_pharynx_morphology0.73986251
87MP0004270_analgesia0.73751502
88MP0002108_abnormal_muscle_morphology0.72535525
89MP0001764_abnormal_homeostasis0.72028990
90MP0000266_abnormal_heart_morphology0.71808455
91MP0003567_abnormal_fetal_cardiomyocyte0.70446401
92MP0002138_abnormal_hepatobiliary_system0.68351553
93MP0009780_abnormal_chondrocyte_physiolo0.67480904
94MP0003950_abnormal_plasma_membrane0.65603263
95MP0005501_abnormal_skin_physiology0.61899088
96MP0001853_heart_inflammation0.60358868
97MP0000003_abnormal_adipose_tissue0.59640560
98MP0005376_homeostasis/metabolism_phenot0.58934977
99MP0000598_abnormal_liver_morphology0.58605494
100MP0008961_abnormal_basal_metabolism0.57152468
101MP0005636_abnormal_mineral_homeostasis0.56865685
102MP0002128_abnormal_blood_circulation0.55381229
103MP0009642_abnormal_blood_homeostasis0.54516200
104MP0000733_abnormal_muscle_development0.54006626
105MP0003868_abnormal_feces_composition0.53652832
106MP0000537_abnormal_urethra_morphology0.53070210
107MP0003279_aneurysm0.51052366
108MP0008260_abnormal_autophagy0.50749122
109MP0002114_abnormal_axial_skeleton0.50472068
110MP0002970_abnormal_white_adipose0.50404179
111MP0009115_abnormal_fat_cell0.50398361
112MP0002909_abnormal_adrenal_gland0.49952817
113MP0002796_impaired_skin_barrier0.49286945
114MP0001727_abnormal_embryo_implantation0.49121113
115MP0009763_increased_sensitivity_to0.48874839
116MP0001849_ear_inflammation0.48762413
117MP0003879_abnormal_hair_cell0.48727320
118MP0001730_embryonic_growth_arrest0.48566287
119MP0009278_abnormal_bone_marrow0.47698308
120MP0003315_abnormal_perineum_morphology0.47188859
121MP0003111_abnormal_nucleus_morphology0.47022604
122MP0000762_abnormal_tongue_morphology0.46948903
123MP0008469_abnormal_protein_level0.45796165
124MP0005448_abnormal_energy_balance0.45661264
125MP0000467_abnormal_esophagus_morphology0.44935927
126MP0002822_catalepsy0.44109414
127MP0005452_abnormal_adipose_tissue0.43101451
128MP0004019_abnormal_vitamin_homeostasis0.41801064
129MP0000013_abnormal_adipose_tissue0.41645146
130MP0003693_abnormal_embryo_hatching0.40358056
131MP0003948_abnormal_gas_homeostasis0.39251899
132MP0002080_prenatal_lethality0.38896212
133MP0008932_abnormal_embryonic_tissue0.37553827
134MP0010094_abnormal_chromosome_stability0.37336928
135MP0004197_abnormal_fetal_growth/weight/0.36222923
136MP0003959_abnormal_lean_body0.35670957
137MP0003984_embryonic_growth_retardation0.35501791
138MP0009384_cardiac_valve_regurgitation0.35281718
139MP0000372_irregular_coat_pigmentation0.32732580
140MP0002088_abnormal_embryonic_growth/wei0.32216525

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.96966369
2Exercise-induced muscle cramps (HP:0003710)5.52116458
3Myoglobinuria (HP:0002913)5.33009012
4Calf muscle hypertrophy (HP:0008981)5.32412050
5Sudden death (HP:0001699)5.31346375
6Muscle hypertrophy of the lower extremities (HP:0008968)5.23710681
7Centrally nucleated skeletal muscle fibers (HP:0003687)4.94925875
8Ventricular tachycardia (HP:0004756)4.65470129
9Muscle fiber splitting (HP:0003555)4.61613314
10Rhabdomyolysis (HP:0003201)4.29903662
11Ulnar deviation of the wrist (HP:0003049)4.25388150
12Hyporeflexia of lower limbs (HP:0002600)4.17680544
13Abnormality of the calf musculature (HP:0001430)3.89891451
14Calcaneovalgus deformity (HP:0001848)3.83045007
15Subaortic stenosis (HP:0001682)3.78261597
16Abnormality of the left ventricular outflow tract (HP:0011103)3.78261597
17Hypoglycemic coma (HP:0001325)3.77382304
18Muscle fiber inclusion bodies (HP:0100299)3.76986496
19Ketosis (HP:0001946)3.74879606
20Ketoacidosis (HP:0001993)3.74071984
21Palpitations (HP:0001962)3.70550500
22Lipoatrophy (HP:0100578)3.69683277
23Abnormality of fatty-acid metabolism (HP:0004359)3.68565278
24Rimmed vacuoles (HP:0003805)3.66340503
25Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.63150492
26Asymmetric septal hypertrophy (HP:0001670)3.57985484
27EMG: myopathic abnormalities (HP:0003458)3.56094047
28Difficulty running (HP:0009046)3.51686599
29Atrial fibrillation (HP:0005110)3.49127308
30Increased connective tissue (HP:0009025)3.45579568
31Dicarboxylic aciduria (HP:0003215)3.40524718
32Abnormality of dicarboxylic acid metabolism (HP:0010995)3.40524718
33Right ventricular cardiomyopathy (HP:0011663)3.36717820
34Deformed tarsal bones (HP:0008119)3.34944064
35Hyperammonemia (HP:0001987)3.32046392
36Hepatic necrosis (HP:0002605)3.31596276
37Distal lower limb amyotrophy (HP:0008944)3.30702966
38Dilated cardiomyopathy (HP:0001644)3.26700390
39Primary atrial arrhythmia (HP:0001692)3.25199127
40Supraventricular tachycardia (HP:0004755)3.18000849
41Hyperglycinuria (HP:0003108)3.17416762
42Type 1 muscle fiber predominance (HP:0003803)3.13377387
43Supraventricular arrhythmia (HP:0005115)3.10210787
44Bulbar palsy (HP:0001283)3.10144556
45Muscle stiffness (HP:0003552)3.10046758
46Myotonia (HP:0002486)3.08109556
47Mildly elevated creatine phosphokinase (HP:0008180)3.06685119
48Nemaline bodies (HP:0003798)3.06431782
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.04292006
50Bundle branch block (HP:0011710)3.03304507
51Absent phalangeal crease (HP:0006109)2.99789584
52Cerebral edema (HP:0002181)2.98610890
53EMG: neuropathic changes (HP:0003445)2.93274076
54Increased muscle lipid content (HP:0009058)2.92285853
55Syncope (HP:0001279)2.89764338
56Abnormality of serine family amino acid metabolism (HP:0010894)2.88399865
57Abnormality of glycine metabolism (HP:0010895)2.88399865
58Abnormality of aromatic amino acid family metabolism (HP:0004338)2.87803457
59Atrioventricular block (HP:0001678)2.82926466
60Heart block (HP:0012722)2.81501222
61Malignant hyperthermia (HP:0002047)2.81154106
62Acute encephalopathy (HP:0006846)2.75161320
63Hepatocellular necrosis (HP:0001404)2.70517692
64Abnormal mitochondria in muscle tissue (HP:0008316)2.70342950
65Xanthomatosis (HP:0000991)2.64859700
66Generalized aminoaciduria (HP:0002909)2.64383836
67Abnormal atrioventricular conduction (HP:0005150)2.63321378
68Prolonged QT interval (HP:0001657)2.60870139
69Difficulty climbing stairs (HP:0003551)2.60694630
70Ventricular arrhythmia (HP:0004308)2.60525724
71Intrahepatic cholestasis (HP:0001406)2.56256291
72Hypoalphalipoproteinemia (HP:0003233)2.54480031
73Acute necrotizing encephalopathy (HP:0006965)2.53954609
74Hyperlipoproteinemia (HP:0010980)2.53732889
75Hyperglycinemia (HP:0002154)2.52772222
76Frequent falls (HP:0002359)2.52394905
77Deep venous thrombosis (HP:0002625)2.50383007
78Generalized muscle weakness (HP:0003324)2.45597801
79Metabolic acidosis (HP:0001942)2.45479515
80Increased intramyocellular lipid droplets (HP:0012240)2.44977270
81Abnormality of the calcaneus (HP:0008364)2.43546492
82Distal arthrogryposis (HP:0005684)2.41790366
83Ragged-red muscle fibers (HP:0003200)2.41421525
84Achilles tendon contracture (HP:0001771)2.39373318
85Lactic acidosis (HP:0003128)2.38838859
86Myopathic facies (HP:0002058)2.35975460
87Abnormal finger flexion creases (HP:0006143)2.35239286
88Scapular winging (HP:0003691)2.32975272
89Cholelithiasis (HP:0001081)2.32877740
90Spinal rigidity (HP:0003306)2.31200882
91Lethargy (HP:0001254)2.27794750
92Abnormality of the foot musculature (HP:0001436)2.27644191
93Lower limb amyotrophy (HP:0007210)2.26859882
94Increased variability in muscle fiber diameter (HP:0003557)2.26006717
95Abnormality of skeletal muscle fiber size (HP:0012084)2.24945690
96Areflexia of lower limbs (HP:0002522)2.24406958
97Conjunctival hamartoma (HP:0100780)2.23486052
98Mitochondrial inheritance (HP:0001427)2.22753195
99Gout (HP:0001997)2.22125769
100Foot dorsiflexor weakness (HP:0009027)2.22113424
101Hypolipoproteinemia (HP:0010981)2.17339215
102Increased CSF lactate (HP:0002490)2.16295836
103Hyperinsulinemic hypoglycemia (HP:0000825)2.15765665
104Abnormal gallbladder morphology (HP:0012437)2.14812285
105Abnormality of the Achilles tendon (HP:0005109)2.14571411
106Ventricular fibrillation (HP:0001663)2.14239011
107Late onset (HP:0003584)2.14234789
108Gowers sign (HP:0003391)2.11270391
109Neck muscle weakness (HP:0000467)2.09211838
110Progressive macrocephaly (HP:0004481)2.07798932
111Progressive muscle weakness (HP:0003323)2.07309084
112Distal lower limb muscle weakness (HP:0009053)2.05829524
113Abnormality of monocarboxylic acid metabolism (HP:0010996)2.05463306
114Round ear (HP:0100830)2.05065103
115Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.03739439
116Limb-girdle muscle atrophy (HP:0003797)2.02798830
117Exercise intolerance (HP:0003546)2.02346146
118Fetal akinesia sequence (HP:0001989)2.00540258
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99904259
120Abnormality of alanine metabolism (HP:0010916)1.99904259
121Hyperalaninemia (HP:0003348)1.99904259
122Abnormality of serum amino acid levels (HP:0003112)1.99124297
123Testicular atrophy (HP:0000029)1.96846730
124Waddling gait (HP:0002515)1.96808535
125Vomiting (HP:0002013)1.95517985
126Weak cry (HP:0001612)1.93074393
127Stridor (HP:0010307)1.91690066
128Slender build (HP:0001533)1.89228225
129Metatarsus adductus (HP:0001840)1.84811633
130Fatigable weakness (HP:0003473)1.81577982
131Abnormality of the neuromuscular junction (HP:0003398)1.81577982
132Abnormal gallbladder physiology (HP:0012438)1.81205475
133Cholecystitis (HP:0001082)1.81205475
134Easy fatigability (HP:0003388)1.78728142
135Diaphragmatic weakness (HP:0009113)1.75306299
136Generalized amyotrophy (HP:0003700)1.71706735
137Respiratory insufficiency due to muscle weakness (HP:0002747)1.69269526
138Muscular dystrophy (HP:0003560)1.65841495
139Abnormality of the shoulder girdle musculature (HP:0001435)1.65382395
140Reticulocytosis (HP:0001923)1.63044296
141Adducted thumb (HP:0001181)1.59798861
142Hyperkalemia (HP:0002153)1.57424826
143Abnormality of glycolysis (HP:0004366)1.56907960
144Proximal amyotrophy (HP:0007126)1.54664734
145Paralysis (HP:0003470)1.53078634
146Shoulder girdle muscle weakness (HP:0003547)1.51949432
147Hip contracture (HP:0003273)1.51813109
148Breech presentation (HP:0001623)1.49155923
149Pelvic girdle muscle weakness (HP:0003749)1.45564738
150Congenital hip dislocation (HP:0001374)1.44835384
151Muscle fiber atrophy (HP:0100295)1.42438379

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.56664035
2BCKDK5.07618679
3OBSCN4.12688315
4PHKG13.92128787
5PHKG23.92128787
6TRIB33.44126195
7PDK33.08261952
8PDK43.08261952
9PKN22.98915598
10LMTK22.62935942
11MYLK2.40687648
12PINK12.32084805
13MAP2K31.99315063
14MUSK1.93863192
15NEK11.93398258
16DMPK1.91549921
17IRAK31.88808434
18PDK21.76910579
19PIK3CA1.71277971
20ERN11.65221915
21MAP3K71.64286822
22TIE11.62070196
23SIK11.50948437
24SCYL21.50197296
25EPHA21.47754315
26RPS6KB21.47431295
27FLT31.43584698
28SMG11.42769750
29PIK3CG1.42184380
30PRPF4B1.31952252
31MAPK121.31167133
32STK241.26063950
33ARAF1.24989451
34CCNB11.22879729
35MAPKAPK31.20194191
36RIPK11.19312531
37FGFR41.16349618
38TESK11.13175389
39INSRR1.12575809
40NME11.06434418
41NME21.05415335
42ILK1.03121408
43LIMK11.03009700
44VRK21.02639434
45PRKAA21.01065020
46MAP3K30.97656037
47PRKD10.93385405
48KDR0.90711885
49MAPK110.88087475
50PRKAA10.87646666
51NEK90.82692972
52MAP2K60.80536013
53EEF2K0.76841571
54MAP2K40.75951639
55TESK20.75673416
56CAMK2D0.75248869
57MAP3K50.74731742
58TGFBR20.73653754
59BRAF0.72171378
60EIF2AK10.72158192
61MAP3K110.70147889
62EPHB10.69020266
63TBK10.65684164
64PTK60.65438715
65PAK30.64563709
66WNK40.64172239
67MAP3K100.63204834
68KSR20.60859020
69GRK70.56449108
70TRPM70.54390819
71IRAK20.53801858
72CAMK40.53412393
73DAPK30.52425266
74CAMK2B0.52357386
75CAMK2G0.52310325
76ICK0.51770482
77PDPK10.50558649
78CDK80.50356184
79CDK120.50038897
80STK40.49286833
81CDK70.49236066
82TYK20.49043772
83LRRK20.47892394
84RPS6KL10.47540190
85RPS6KC10.47540190
86ROCK10.46590060
87MOS0.46580671
88LATS20.46536953
89CDC70.46129382
90RPS6KA60.46099946
91MAP2K10.43348856
92RAF10.43226988
93AURKA0.42988490
94JAK20.41789702
95PDK10.41690870
96CAMK1D0.41572635
97MAPK40.41174160
98PRKACG0.40797466
99PKN10.40651348
100AKT20.40592548
101MARK20.39824695
102MAP3K130.37759615
103MAP4K10.35716931
104MST1R0.35138187
105PRKG20.35022477
106PRKACB0.34179462
107TAOK10.33149019
108PRKD20.32926493
109MAP3K10.32018945
110JAK10.32000685
111PRKD30.31403986
112PRKCI0.31270754
113CAMK10.31127168
114STK38L0.30343937
115PDGFRA0.29572729
116PIM20.29521119
117RPS6KA10.29222906
118MAP3K60.27833004
119PRKACA0.27480478
120MAPKAPK50.27354973
121TAOK20.25283025
122RPS6KB10.25056840
123KIT0.24804835
124ABL20.24357402
125TAOK30.24182193
126MAP3K80.22882339
127MAPK100.22880563
128DYRK1B0.22341129
129PBK0.21289933
130MTOR0.21244976
131PAK40.19967263
132PRKCH0.19884313
133AURKB0.19661308
134STK380.19575531
135MAP2K20.19320619
136MAPK70.16709013
137RPS6KA20.15672414
138BTK0.15305234
139CDC42BPA0.14899695

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.27729592
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.79891427
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.63848737
4Propanoate metabolism_Homo sapiens_hsa006403.61227630
5Fatty acid degradation_Homo sapiens_hsa000713.49164656
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.22390004
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.77203362
8Fatty acid metabolism_Homo sapiens_hsa012122.55250740
9Carbon metabolism_Homo sapiens_hsa012002.42071489
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.36849107
11Pyruvate metabolism_Homo sapiens_hsa006202.19279327
12Arginine biosynthesis_Homo sapiens_hsa002202.17706966
13Butanoate metabolism_Homo sapiens_hsa006502.17052848
14Tryptophan metabolism_Homo sapiens_hsa003802.14399410
15Cardiac muscle contraction_Homo sapiens_hsa042602.00076847
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.86764825
17PPAR signaling pathway_Homo sapiens_hsa033201.85358332
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.84900787
19Parkinsons disease_Homo sapiens_hsa050121.81555524
20Peroxisome_Homo sapiens_hsa041461.76072979
21Oxidative phosphorylation_Homo sapiens_hsa001901.74498386
22Nitrogen metabolism_Homo sapiens_hsa009101.74367594
23beta-Alanine metabolism_Homo sapiens_hsa004101.70510223
24Fatty acid elongation_Homo sapiens_hsa000621.67597772
25Starch and sucrose metabolism_Homo sapiens_hsa005001.63380885
26Biosynthesis of amino acids_Homo sapiens_hsa012301.58990670
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57967251
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.51240855
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50933014
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49053735
31Dilated cardiomyopathy_Homo sapiens_hsa054141.47641328
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.47005203
33DNA replication_Homo sapiens_hsa030301.45710942
34Ribosome_Homo sapiens_hsa030101.42670593
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34847696
36Base excision repair_Homo sapiens_hsa034101.33945179
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33038499
38Alzheimers disease_Homo sapiens_hsa050101.29354464
39Arginine and proline metabolism_Homo sapiens_hsa003301.18078547
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18004570
41Caffeine metabolism_Homo sapiens_hsa002321.14879332
42Phenylalanine metabolism_Homo sapiens_hsa003601.11354039
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.07025836
44Sulfur metabolism_Homo sapiens_hsa009201.06785859
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05526587
46Complement and coagulation cascades_Homo sapiens_hsa046101.05361554
47Sulfur relay system_Homo sapiens_hsa041221.01470989
48Fat digestion and absorption_Homo sapiens_hsa049750.97957194
49Huntingtons disease_Homo sapiens_hsa050160.93628331
50Chemical carcinogenesis_Homo sapiens_hsa052040.92880899
51Bile secretion_Homo sapiens_hsa049760.89433439
52Histidine metabolism_Homo sapiens_hsa003400.88189255
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87746492
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87535630
55Insulin resistance_Homo sapiens_hsa049310.86531647
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.85507832
57Selenocompound metabolism_Homo sapiens_hsa004500.85438012
58Lysine degradation_Homo sapiens_hsa003100.84946873
59Tyrosine metabolism_Homo sapiens_hsa003500.83645473
60VEGF signaling pathway_Homo sapiens_hsa043700.82731888
61Folate biosynthesis_Homo sapiens_hsa007900.81335181
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81264985
63Pyrimidine metabolism_Homo sapiens_hsa002400.80986980
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.80735119
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77853832
66Glucagon signaling pathway_Homo sapiens_hsa049220.74366678
67ABC transporters_Homo sapiens_hsa020100.72762107
68Pentose phosphate pathway_Homo sapiens_hsa000300.72543636
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72460726
70Other glycan degradation_Homo sapiens_hsa005110.72260624
71Bladder cancer_Homo sapiens_hsa052190.71920379
72Galactose metabolism_Homo sapiens_hsa000520.70460017
73Oxytocin signaling pathway_Homo sapiens_hsa049210.69795915
74Fatty acid biosynthesis_Homo sapiens_hsa000610.68901761
75Purine metabolism_Homo sapiens_hsa002300.67255040
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64979470
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64644653
78Fructose and mannose metabolism_Homo sapiens_hsa000510.62386165
79Glycerolipid metabolism_Homo sapiens_hsa005610.60710248
80Insulin signaling pathway_Homo sapiens_hsa049100.60648206
81mTOR signaling pathway_Homo sapiens_hsa041500.60311474
82Retinol metabolism_Homo sapiens_hsa008300.60080917
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60075791
84Acute myeloid leukemia_Homo sapiens_hsa052210.59746828
85Non-small cell lung cancer_Homo sapiens_hsa052230.59340154
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59203274
87Nucleotide excision repair_Homo sapiens_hsa034200.57644629
88Thyroid cancer_Homo sapiens_hsa052160.55973902
89Metabolic pathways_Homo sapiens_hsa011000.55440104
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.54384085
91AMPK signaling pathway_Homo sapiens_hsa041520.53256209
92Viral myocarditis_Homo sapiens_hsa054160.50764003
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48950345
94Tight junction_Homo sapiens_hsa045300.48530344
95Notch signaling pathway_Homo sapiens_hsa043300.47529584
96Staphylococcus aureus infection_Homo sapiens_hsa051500.47188290
97Glioma_Homo sapiens_hsa052140.43539204
98Chronic myeloid leukemia_Homo sapiens_hsa052200.42977111
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40900102
100Spliceosome_Homo sapiens_hsa030400.40071504
101GnRH signaling pathway_Homo sapiens_hsa049120.39845057
102Endometrial cancer_Homo sapiens_hsa052130.39691444
103Mismatch repair_Homo sapiens_hsa034300.38803193
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.38742617
105Prion diseases_Homo sapiens_hsa050200.37879310
106Glutathione metabolism_Homo sapiens_hsa004800.35989184
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35824300
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35191620
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34525882
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33213760
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31651138
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.28760370
113ErbB signaling pathway_Homo sapiens_hsa040120.20600477
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.19833886
115Long-term potentiation_Homo sapiens_hsa047200.18379435
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17079892
117Pancreatic cancer_Homo sapiens_hsa052120.16323798
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.15820644
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.14604770
120Vitamin digestion and absorption_Homo sapiens_hsa049770.14430347
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14172844
122Linoleic acid metabolism_Homo sapiens_hsa005910.10220479
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.09992711
124Circadian rhythm_Homo sapiens_hsa047100.06072336
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.05695536
126Vitamin B6 metabolism_Homo sapiens_hsa007500.05192121
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.03670704
128Calcium signaling pathway_Homo sapiens_hsa040200.02232645
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.01082735
130HIF-1 signaling pathway_Homo sapiens_hsa040660.00871098
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.00357429
132One carbon pool by folate_Homo sapiens_hsa00670-0.0793520
133Focal adhesion_Homo sapiens_hsa04510-0.0763103
134Pancreatic secretion_Homo sapiens_hsa04972-0.0574429
135Type II diabetes mellitus_Homo sapiens_hsa04930-0.0117688

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