MACROD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.41388996
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.17950237
3synaptic vesicle maturation (GO:0016188)5.00664649
4vocalization behavior (GO:0071625)4.97509752
5synaptic vesicle exocytosis (GO:0016079)4.93547168
6locomotory exploration behavior (GO:0035641)4.90984631
7neuron cell-cell adhesion (GO:0007158)4.87783383
8behavioral response to nicotine (GO:0035095)4.86625462
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.85895831
10glutamate secretion (GO:0014047)4.71378252
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.71336315
12regulation of synaptic vesicle exocytosis (GO:2000300)4.60822673
13protein localization to synapse (GO:0035418)4.51045690
14cAMP catabolic process (GO:0006198)4.46475593
15regulation of glutamate receptor signaling pathway (GO:1900449)4.29498768
16cyclic nucleotide catabolic process (GO:0009214)4.26242042
17detection of light stimulus involved in sensory perception (GO:0050962)4.23955490
18detection of light stimulus involved in visual perception (GO:0050908)4.23955490
19exploration behavior (GO:0035640)4.23207410
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.22842767
21regulation of synaptic vesicle transport (GO:1902803)4.20202443
22neuronal action potential propagation (GO:0019227)4.15671482
23fucose catabolic process (GO:0019317)4.02917796
24L-fucose metabolic process (GO:0042354)4.02917796
25L-fucose catabolic process (GO:0042355)4.02917796
26neurotransmitter secretion (GO:0007269)4.01836198
27positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.00393829
28acrosome assembly (GO:0001675)3.98933319
29layer formation in cerebral cortex (GO:0021819)3.98419780
30synaptic vesicle docking involved in exocytosis (GO:0016081)3.97815106
31glutamate receptor signaling pathway (GO:0007215)3.97718963
32synaptic transmission, glutamatergic (GO:0035249)3.92470656
33neuron-neuron synaptic transmission (GO:0007270)3.87487713
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.83207922
35auditory behavior (GO:0031223)3.80262415
36regulation of neuronal synaptic plasticity (GO:0048168)3.78736286
37neurotransmitter-gated ion channel clustering (GO:0072578)3.73102250
38proline transport (GO:0015824)3.72010104
39positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.71135215
40neuron recognition (GO:0008038)3.69757464
41regulation of hippo signaling (GO:0035330)3.68588436
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.67577561
43regulation of synapse structural plasticity (GO:0051823)3.67095774
44positive regulation of membrane potential (GO:0045838)3.63779424
45neuronal action potential (GO:0019228)3.58942904
46neurotransmitter transport (GO:0006836)3.53765877
47dendritic spine morphogenesis (GO:0060997)3.53638683
48positive regulation of uterine smooth muscle contraction (GO:0070474)3.51412217
49protein polyglutamylation (GO:0018095)3.50721511
50gamma-aminobutyric acid transport (GO:0015812)3.47420057
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.41192118
52innervation (GO:0060384)3.40654257
53gamma-aminobutyric acid signaling pathway (GO:0007214)3.40184630
54postsynaptic membrane organization (GO:0001941)3.38612774
55regulation of excitatory postsynaptic membrane potential (GO:0060079)3.38419742
56cellular potassium ion homeostasis (GO:0030007)3.38000399
57long-term memory (GO:0007616)3.35951767
58positive regulation of synapse maturation (GO:0090129)3.33412588
59response to auditory stimulus (GO:0010996)3.31116351
60transmission of nerve impulse (GO:0019226)3.29799298
61negative regulation of Rho protein signal transduction (GO:0035024)3.28357917
62presynaptic membrane assembly (GO:0097105)3.27986267
63axonal fasciculation (GO:0007413)3.27603061
64establishment of protein localization to Golgi (GO:0072600)3.27338349
65auditory receptor cell differentiation (GO:0042491)3.26066879
66behavioral response to ethanol (GO:0048149)3.25545085
67regulation of postsynaptic membrane potential (GO:0060078)3.24941726
68regulation of dendritic spine morphogenesis (GO:0061001)3.23773278
69detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.23411194
70positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.20262608
71startle response (GO:0001964)3.18820746
72regulation of neurotransmitter levels (GO:0001505)3.17508100
73cell migration in hindbrain (GO:0021535)3.17484507
74synaptic vesicle endocytosis (GO:0048488)3.16430882
75dendrite morphogenesis (GO:0048813)3.15819324
76glycosphingolipid biosynthetic process (GO:0006688)3.15397336
77regulation of neurotransmitter secretion (GO:0046928)3.15271152
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.15258394
79regulation of synaptic plasticity (GO:0048167)3.14998042
80axoneme assembly (GO:0035082)3.14410702
81mechanosensory behavior (GO:0007638)3.13906868
82indolalkylamine catabolic process (GO:0046218)3.13039457
83tryptophan catabolic process (GO:0006569)3.13039457
84indole-containing compound catabolic process (GO:0042436)3.13039457
85positive regulation of neurotransmitter secretion (GO:0001956)3.13029181
86positive regulation of synaptic transmission, GABAergic (GO:0032230)3.12453215
87membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.12382655
88synapse assembly (GO:0007416)3.12299427
89regulation of vesicle fusion (GO:0031338)3.11947215
90C4-dicarboxylate transport (GO:0015740)3.09361078
91regulation of synaptic transmission, glutamatergic (GO:0051966)3.08843137
92negative regulation of synaptic transmission, GABAergic (GO:0032229)3.08367394
93kynurenine metabolic process (GO:0070189)3.07142390
94presynaptic membrane organization (GO:0097090)3.05968191
95behavioral defense response (GO:0002209)3.05855366
96behavioral fear response (GO:0001662)3.05855366
97detection of calcium ion (GO:0005513)3.05153967
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.04067947
99long-term synaptic potentiation (GO:0060291)3.03617170
100positive regulation of fatty acid transport (GO:2000193)2.99668872
101prepulse inhibition (GO:0060134)2.99621738
102negative regulation of cytosolic calcium ion concentration (GO:0051481)2.97994056
103regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96818676
104retinal cone cell development (GO:0046549)2.96465426
105regulation of neurotransmitter transport (GO:0051588)2.95510340
106response to histamine (GO:0034776)2.95333393
107positive regulation of neurotransmitter transport (GO:0051590)2.94718555
108glycine transport (GO:0015816)2.94312893
109positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.93431739
110membrane hyperpolarization (GO:0060081)2.93029167
111protein targeting to Golgi (GO:0000042)2.93013479
112indolalkylamine metabolic process (GO:0006586)2.92553973
113cerebellar Purkinje cell differentiation (GO:0021702)2.92508244
114negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91122290
115protein localization to cilium (GO:0061512)2.89963916
116cellular ketone body metabolic process (GO:0046950)2.88843296
117activation of protein kinase A activity (GO:0034199)2.88209135
118cochlea development (GO:0090102)2.87556353
119fear response (GO:0042596)2.87546910
120dendritic spine organization (GO:0097061)2.86255146
121response to pheromone (GO:0019236)2.85225685
122synaptic transmission (GO:0007268)2.85172097
123pyrimidine nucleobase catabolic process (GO:0006208)2.83669721
124central nervous system projection neuron axonogenesis (GO:0021952)2.83406896
125neuromuscular process controlling balance (GO:0050885)2.83183586
126membrane depolarization (GO:0051899)2.82720266
127cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.81892840
128regulation of cilium movement (GO:0003352)2.81303487
129learning (GO:0007612)2.81030234
130behavioral response to cocaine (GO:0048148)2.80886740
131intraspecies interaction between organisms (GO:0051703)2.80519557
132social behavior (GO:0035176)2.80519557
133epithelial cilium movement (GO:0003351)2.80509523
134membrane depolarization during action potential (GO:0086010)2.80261855
135synapse organization (GO:0050808)2.80112009
136positive regulation of dendritic spine development (GO:0060999)2.80016443
137regulation of dendritic spine development (GO:0060998)2.78561653
138DNA deamination (GO:0045006)2.78479371
139regulation of synapse maturation (GO:0090128)2.76435909
140protein localization to Golgi apparatus (GO:0034067)2.75756952
141nucleobase catabolic process (GO:0046113)2.73872779
142cilium morphogenesis (GO:0060271)2.71389607
143sulfation (GO:0051923)2.71240738
144serotonin metabolic process (GO:0042428)2.70758614
145regulation of uterine smooth muscle contraction (GO:0070472)2.70698273
146regulation of gene silencing by RNA (GO:0060966)2.68492177
147regulation of posttranscriptional gene silencing (GO:0060147)2.68492177
148regulation of gene silencing by miRNA (GO:0060964)2.68492177
149protein K11-linked deubiquitination (GO:0035871)2.67181215
150cGMP metabolic process (GO:0046068)2.65813863
151calcium ion import (GO:0070509)2.61455671
152regulation of inositol phosphate biosynthetic process (GO:0010919)2.60916106
153tryptophan metabolic process (GO:0006568)2.60243505
154retrograde transport, vesicle recycling within Golgi (GO:0000301)2.59349404
155regulation of action potential (GO:0098900)2.58225369
156indole-containing compound metabolic process (GO:0042430)2.57302755
157cilium movement (GO:0003341)2.56507773
158positive regulation of icosanoid secretion (GO:0032305)2.54075634
159primary amino compound metabolic process (GO:1901160)2.53746670
160action potential (GO:0001508)2.53621733
161ketone body metabolic process (GO:1902224)2.52882658
162cardiac right ventricle morphogenesis (GO:0003215)2.51024639
163water-soluble vitamin biosynthetic process (GO:0042364)2.50462961
164multicellular organism reproduction (GO:0032504)2.50128778
165neurotransmitter metabolic process (GO:0042133)2.49712517
166regulation of hexokinase activity (GO:1903299)2.48867591
167regulation of glucokinase activity (GO:0033131)2.48867591
168piRNA metabolic process (GO:0034587)2.48492522
169regulation of protein kinase A signaling (GO:0010738)2.47471376
170cilium organization (GO:0044782)2.47088378
171cilium or flagellum-dependent cell motility (GO:0001539)2.46608616
172adaptation of signaling pathway (GO:0023058)2.45704513
173negative regulation of mast cell activation (GO:0033004)2.44453960
174regulation of rhodopsin mediated signaling pathway (GO:0022400)2.42972086
175cilium assembly (GO:0042384)2.42935857
176platelet dense granule organization (GO:0060155)2.41769186
177inner ear receptor stereocilium organization (GO:0060122)2.41656863
178rhodopsin mediated signaling pathway (GO:0016056)2.40171660

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.57234723
2* GBX2_23144817_ChIP-Seq_PC3_Human3.82567804
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99836486
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97676815
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82368559
6REST_21632747_ChIP-Seq_MESCs_Mouse2.61582805
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.50709258
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50605860
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50605860
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50210665
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46717558
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38767584
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36909984
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33526874
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28474027
16* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15395168
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.14601526
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14542941
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.13730137
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.13489393
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11075938
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.07738614
23DROSHA_22980978_ChIP-Seq_HELA_Human2.06145325
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.04068222
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03212237
26TAF15_26573619_Chip-Seq_HEK293_Human2.02645940
27EWS_26573619_Chip-Seq_HEK293_Human1.97456052
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93971450
29* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91639694
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86983927
31AR_21572438_ChIP-Seq_LNCaP_Human1.82172545
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77763950
33* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75705718
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.74701377
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72464117
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62314137
37* P300_19829295_ChIP-Seq_ESCs_Human1.61862229
38IRF1_19129219_ChIP-ChIP_H3396_Human1.61106404
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60358407
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59191464
41IGF1R_20145208_ChIP-Seq_DFB_Human1.57390203
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54124662
43ZNF274_21170338_ChIP-Seq_K562_Hela1.53931106
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52669426
45CBP_20019798_ChIP-Seq_JUKART_Human1.52669426
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.50922896
47* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46201525
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42923050
49RNF2_27304074_Chip-Seq_NSC_Mouse1.40524752
50VDR_22108803_ChIP-Seq_LS180_Human1.40293204
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39697755
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.39681787
53* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38361308
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38159091
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36254860
56STAT3_23295773_ChIP-Seq_U87_Human1.32757088
57* AR_25329375_ChIP-Seq_VCAP_Human1.32497506
58* PIAS1_25552417_ChIP-Seq_VCAP_Human1.32436851
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.29825929
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.28606273
61FUS_26573619_Chip-Seq_HEK293_Human1.28390421
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27882033
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27510475
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27186350
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26609142
66TCF4_22108803_ChIP-Seq_LS180_Human1.26170426
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25012692
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.24596980
69SOX2_19829295_ChIP-Seq_ESCs_Human1.23864044
70NANOG_19829295_ChIP-Seq_ESCs_Human1.23864044
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23511697
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23327408
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22687688
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.21757430
75* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20428904
76* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20222755
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19813213
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18154538
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17678895
80* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17366869
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16817184
82* P53_22387025_ChIP-Seq_ESCs_Mouse1.16661402
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15523648
84AR_19668381_ChIP-Seq_PC3_Human1.15093972
85RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14686034
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14437304
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.13492102
88TP53_16413492_ChIP-PET_HCT116_Human1.13125169
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12194183
90TCF4_23295773_ChIP-Seq_U87_Human1.12160257
91P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12057141
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10806038
93RXR_22108803_ChIP-Seq_LS180_Human1.10581025
94TP53_22573176_ChIP-Seq_HFKS_Human1.10145120
95* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09059609
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.08654443
97PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07849881
98JUN_21703547_ChIP-Seq_K562_Human1.07187197
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.06302116
100CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06238900
101* PRDM14_20953172_ChIP-Seq_ESCs_Human1.05725807
102* E2F1_18555785_Chip-Seq_ESCs_Mouse1.05339108
103YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04542271
104RING1B_27294783_Chip-Seq_NPCs_Mouse1.03906567
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03781857
106* RUNX2_22187159_ChIP-Seq_PCA_Human1.03645724
107* NANOG_18555785_Chip-Seq_ESCs_Mouse1.03488644
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03174911
109ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02651545
110CDX2_22108803_ChIP-Seq_LS180_Human1.02218638
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01809219
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.01425622
113RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00566536
114* ARNT_22903824_ChIP-Seq_MCF-7_Human1.00462133
115FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00215628
116* STAT3_18555785_Chip-Seq_ESCs_Mouse0.99374509
117WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99127017
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97874886
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97874886
120FLI1_27457419_Chip-Seq_LIVER_Mouse0.97354792
121KDM2B_26808549_Chip-Seq_REH_Human0.94999576
122SMAD_19615063_ChIP-ChIP_OVARY_Human0.94965371
123* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94698465
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93862009
125* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93365524
126SMAD4_21741376_ChIP-Seq_HESCs_Human0.92995059
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92899560
128SMAD3_21741376_ChIP-Seq_ESCs_Human0.91710561
129SMAD4_21741376_ChIP-Seq_EPCs_Human0.91710162
130* ER_23166858_ChIP-Seq_MCF-7_Human0.90822484
131* AHR_22903824_ChIP-Seq_MCF-7_Human0.89302411
132BCAT_22108803_ChIP-Seq_LS180_Human0.88433064

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.69417301
2MP0003880_abnormal_central_pattern4.46898643
3MP0003635_abnormal_synaptic_transmissio3.79170191
4MP0004270_analgesia3.72229839
5MP0002063_abnormal_learning/memory/cond3.12652492
6MP0009745_abnormal_behavioral_response3.11102917
7MP0001968_abnormal_touch/_nociception3.11045222
8MP0002064_seizures2.75808092
9MP0002734_abnormal_mechanical_nocicepti2.71426956
10MP0002736_abnormal_nociception_after2.69574820
11MP0009046_muscle_twitch2.68969221
12MP0002572_abnormal_emotion/affect_behav2.62566348
13MP0002735_abnormal_chemical_nociception2.52007840
14MP0001486_abnormal_startle_reflex2.44945965
15MP0008877_abnormal_DNA_methylation2.44324024
16MP0005423_abnormal_somatic_nervous2.41415936
17MP0002272_abnormal_nervous_system2.36175681
18MP0003136_yellow_coat_color2.32593525
19MP0002733_abnormal_thermal_nociception2.17721928
20MP0002822_catalepsy2.09877330
21MP0001440_abnormal_grooming_behavior2.08087863
22MP0006276_abnormal_autonomic_nervous2.07574467
23MP0002067_abnormal_sensory_capabilities2.02796768
24MP0001970_abnormal_pain_threshold1.98281910
25MP0000778_abnormal_nervous_system1.98252846
26MP0004133_heterotaxia1.96970519
27MP0002928_abnormal_bile_duct1.94422626
28MP0002184_abnormal_innervation1.90989100
29MP0004043_abnormal_pH_regulation1.87369812
30MP0001501_abnormal_sleep_pattern1.78737615
31MP0001529_abnormal_vocalization1.75667307
32MP0002557_abnormal_social/conspecific_i1.74892427
33MP0005646_abnormal_pituitary_gland1.74752126
34MP0008875_abnormal_xenobiotic_pharmacok1.72497203
35MP0005386_behavior/neurological_phenoty1.72373880
36MP0004924_abnormal_behavior1.72373880
37MP0004147_increased_porphyrin_level1.68971988
38MP0001984_abnormal_olfaction1.66759812
39MP0003329_amyloid_beta_deposits1.64823790
40MP0009780_abnormal_chondrocyte_physiolo1.64592028
41MP0003879_abnormal_hair_cell1.61177060
42MP0003252_abnormal_bile_duct1.59043665
43MP0004811_abnormal_neuron_physiology1.56573530
44MP0005174_abnormal_tail_pigmentation1.55289314
45MP0005084_abnormal_gallbladder_morpholo1.53472557
46MP0001905_abnormal_dopamine_level1.52632583
47MP0001986_abnormal_taste_sensitivity1.49625540
48MP0004858_abnormal_nervous_system1.48186824
49MP0000955_abnormal_spinal_cord1.47908169
50MP0002909_abnormal_adrenal_gland1.46906798
51MP0004885_abnormal_endolymph1.46348041
52MP0008569_lethality_at_weaning1.43728284
53MP0005253_abnormal_eye_physiology1.43568388
54MP0002066_abnormal_motor_capabilities/c1.41988523
55MP0003787_abnormal_imprinting1.41434090
56MP0002138_abnormal_hepatobiliary_system1.41350217
57MP0002882_abnormal_neuron_morphology1.38807344
58MP0001502_abnormal_circadian_rhythm1.37694032
59MP0001188_hyperpigmentation1.34252116
60MP0004142_abnormal_muscle_tone1.31744908
61MP0000372_irregular_coat_pigmentation1.31222240
62MP0010386_abnormal_urinary_bladder1.28802844
63MP0002163_abnormal_gland_morphology1.26098584
64MP0003646_muscle_fatigue1.25144631
65MP0002938_white_spotting1.24952935
66MP0004742_abnormal_vestibular_system1.24893452
67MP0005645_abnormal_hypothalamus_physiol1.21276715
68MP0005085_abnormal_gallbladder_physiolo1.16774250
69MP0002234_abnormal_pharynx_morphology1.15275821
70MP0000427_abnormal_hair_cycle1.14175418
71MP0003633_abnormal_nervous_system1.10932699
72MP0002152_abnormal_brain_morphology1.07914694
73MP0008789_abnormal_olfactory_epithelium1.06688904
74MP0002837_dystrophic_cardiac_calcinosis1.06297857
75MP0001963_abnormal_hearing_physiology1.05746428
76MP0005195_abnormal_posterior_eye1.04772860
77MP0001765_abnormal_ion_homeostasis1.04586560
78MP0000631_abnormal_neuroendocrine_gland1.02302615
79MP0005332_abnormal_amino_acid1.02101634
80MP0002229_neurodegeneration1.01193822
81MP0002069_abnormal_eating/drinking_beha1.00503063
82MP0005379_endocrine/exocrine_gland_phen0.99683527
83MP0005551_abnormal_eye_electrophysiolog0.99600505
84MP0001485_abnormal_pinna_reflex0.98169418
85MP0002102_abnormal_ear_morphology0.97561478
86MP0002638_abnormal_pupillary_reflex0.96789536
87MP0003121_genomic_imprinting0.96207753
88MP0003631_nervous_system_phenotype0.95165910
89MP0005535_abnormal_body_temperature0.94859110
90MP0000230_abnormal_systemic_arterial0.94777003
91MP0003122_maternal_imprinting0.94146369
92MP0000751_myopathy0.94099955
93MP0008961_abnormal_basal_metabolism0.93982096
94MP0004145_abnormal_muscle_electrophysio0.93322083
95MP0002752_abnormal_somatic_nervous0.92949387
96MP0003950_abnormal_plasma_membrane0.91551784
97MP0008872_abnormal_physiological_respon0.89636400
98MP0003283_abnormal_digestive_organ0.86727334
99MP0004215_abnormal_myocardial_fiber0.85383828
100MP0002095_abnormal_skin_pigmentation0.84624025
101MP0005220_abnormal_exocrine_pancreas0.83917066
102MP0002160_abnormal_reproductive_system0.81728002
103MP0002876_abnormal_thyroid_physiology0.80955377
104MP0008775_abnormal_heart_ventricle0.80141952
105MP0000026_abnormal_inner_ear0.79848756
106MP0003011_delayed_dark_adaptation0.78685783
107MP0004233_abnormal_muscle_weight0.78426232
108MP0005394_taste/olfaction_phenotype0.78407018
109MP0005499_abnormal_olfactory_system0.78407018
110MP0006072_abnormal_retinal_apoptosis0.77998962
111MP0004484_altered_response_of0.77369421
112MP0001177_atelectasis0.77135664
113MP0002693_abnormal_pancreas_physiology0.73782169
114MP0000569_abnormal_digit_pigmentation0.72610618
115MP0001664_abnormal_digestion0.71861744
116MP0008874_decreased_physiological_sensi0.70872475
117MP0005187_abnormal_penis_morphology0.68141540
118MP0004085_abnormal_heartbeat0.67282342
119MP0003195_calcinosis0.66621152
120MP0003634_abnormal_glial_cell0.65702778
121MP0006292_abnormal_olfactory_placode0.63123428
122MP0003861_abnormal_nervous_system0.62968386
123MP0005410_abnormal_fertilization0.59765216
124MP0003632_abnormal_nervous_system0.58762852
125MP0001299_abnormal_eye_distance/0.56554005
126MP0003137_abnormal_impulse_conducting0.56211933
127MP0000920_abnormal_myelination0.55999835
128MP0003956_abnormal_body_size0.52270185
129MP0000538_abnormal_urinary_bladder0.52095193
130MP0005409_darkened_coat_color0.51864184
131MP0003698_abnormal_male_reproductive0.51683801

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.40187976
2Myokymia (HP:0002411)6.14403842
3Congenital stationary night blindness (HP:0007642)5.26033283
4Focal seizures (HP:0007359)4.75572970
5Epileptic encephalopathy (HP:0200134)4.47165886
6Visual hallucinations (HP:0002367)4.27182416
7Pancreatic fibrosis (HP:0100732)4.20148605
8Molar tooth sign on MRI (HP:0002419)4.13117466
9Abnormality of midbrain morphology (HP:0002418)4.13117466
10Increased circulating renin level (HP:0000848)3.99318904
11Febrile seizures (HP:0002373)3.91537022
12Pancreatic cysts (HP:0001737)3.86255626
13Atonic seizures (HP:0010819)3.82862703
14Hyperventilation (HP:0002883)3.59619313
15Progressive cerebellar ataxia (HP:0002073)3.58898634
16Absence seizures (HP:0002121)3.58058955
17Type II lissencephaly (HP:0007260)3.50134005
18Abnormal rod and cone electroretinograms (HP:0008323)3.50004100
19True hermaphroditism (HP:0010459)3.47233715
20Abnormality of macular pigmentation (HP:0008002)3.42644152
21Hypoplasia of the fovea (HP:0007750)3.32944777
22Aplasia/Hypoplasia of the fovea (HP:0008060)3.32944777
23Generalized tonic-clonic seizures (HP:0002069)3.32135610
24Broad-based gait (HP:0002136)3.31900710
25Nephronophthisis (HP:0000090)3.25230618
26Abnormality of the renal medulla (HP:0100957)3.24982685
27Chronic hepatic failure (HP:0100626)3.20439081
28Dialeptic seizures (HP:0011146)3.17972346
29Abnormality of the renal cortex (HP:0011035)3.13148753
30Hypomagnesemia (HP:0002917)3.11613651
31Aplasia/Hypoplasia of the tibia (HP:0005772)3.11157675
32Limb dystonia (HP:0002451)3.06774492
33Metabolic alkalosis (HP:0200114)3.03517708
34Action tremor (HP:0002345)3.02483066
35Abnormal eating behavior (HP:0100738)3.00022704
36Anxiety (HP:0000739)2.94938286
37Chorioretinal atrophy (HP:0000533)2.94912128
38Supranuclear gaze palsy (HP:0000605)2.85120788
39Poor eye contact (HP:0000817)2.83914311
40Severe visual impairment (HP:0001141)2.78176601
41Abolished electroretinogram (ERG) (HP:0000550)2.74589702
42Ankle clonus (HP:0011448)2.73145514
43Albinism (HP:0001022)2.70798883
44Hypokalemic alkalosis (HP:0001949)2.70444450
45Polyuria (HP:0000103)2.70367114
46Mutism (HP:0002300)2.68136026
47Polyphagia (HP:0002591)2.67505689
48Abnormality of the fovea (HP:0000493)2.67285252
49Renal cortical cysts (HP:0000803)2.66148475
50Impaired vibration sensation in the lower limbs (HP:0002166)2.65985707
51Abnormality of magnesium homeostasis (HP:0004921)2.65953707
52Hyperactive renin-angiotensin system (HP:0000841)2.65101066
53Gaze-evoked nystagmus (HP:0000640)2.63805675
54Gout (HP:0001997)2.63044256
55Amblyopia (HP:0000646)2.62172587
56Tubular atrophy (HP:0000092)2.61546723
57Abnormal drinking behavior (HP:0030082)2.60427236
58Polydipsia (HP:0001959)2.60427236
59Pheochromocytoma (HP:0002666)2.56529003
60Epileptiform EEG discharges (HP:0011182)2.54902670
61Attenuation of retinal blood vessels (HP:0007843)2.52300071
62Drooling (HP:0002307)2.52216970
63Excessive salivation (HP:0003781)2.52216970
64Fetal akinesia sequence (HP:0001989)2.49069156
65Torticollis (HP:0000473)2.48811920
66Urinary bladder sphincter dysfunction (HP:0002839)2.48799355
67Abnormal social behavior (HP:0012433)2.48681791
68Impaired social interactions (HP:0000735)2.48681791
69Short tibia (HP:0005736)2.48246616
70Dysmetria (HP:0001310)2.47734936
71Abnormal urine output (HP:0012590)2.46926912
72Central scotoma (HP:0000603)2.45070361
73EEG with generalized epileptiform discharges (HP:0011198)2.44803664
74Depression (HP:0000716)2.42994548
75Dysdiadochokinesis (HP:0002075)2.42804938
76Focal dystonia (HP:0004373)2.41954347
77Urinary urgency (HP:0000012)2.40334011
78Papilledema (HP:0001085)2.38417432
79Genital tract atresia (HP:0001827)2.37081046
80Aplasia/Hypoplasia of the tongue (HP:0010295)2.36982981
81Abnormality of the corticospinal tract (HP:0002492)2.36541864
82Spastic gait (HP:0002064)2.36074638
83Postural instability (HP:0002172)2.32870146
84Gait imbalance (HP:0002141)2.32047712
85Abnormality of renal excretion (HP:0011036)2.32034496
86Lissencephaly (HP:0001339)2.31359740
87Cystic liver disease (HP:0006706)2.31238738
88Hypsarrhythmia (HP:0002521)2.29979478
89Truncal ataxia (HP:0002078)2.29155929
90Pachygyria (HP:0001302)2.27655514
91Fair hair (HP:0002286)2.26168739
92Craniofacial dystonia (HP:0012179)2.24967779
93Hemiparesis (HP:0001269)2.22922300
94Abnormality of renin-angiotensin system (HP:0000847)2.22554932
95Neurofibrillary tangles (HP:0002185)2.21532595
96Progressive inability to walk (HP:0002505)2.20013008
97Decreased electroretinogram (ERG) amplitude (HP:0000654)2.19772687
98Neuroendocrine neoplasm (HP:0100634)2.15524762
99Inability to walk (HP:0002540)2.15523403
100Cerebral inclusion bodies (HP:0100314)2.15410388
101Decreased central vision (HP:0007663)2.15207088
102Cerebellar dysplasia (HP:0007033)2.14863679
103Scanning speech (HP:0002168)2.13940753
104Status epilepticus (HP:0002133)2.12899410
105Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12438550
106Agitation (HP:0000713)2.12001521
107Severe muscular hypotonia (HP:0006829)2.11180603
108Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.10407278
109Termporal pattern (HP:0011008)2.10363553
110Insidious onset (HP:0003587)2.10363553
111Aplasia/Hypoplasia affecting the retina (HP:0008061)2.09345374
112Anterior segment dysgenesis (HP:0007700)2.09173573
113Scotoma (HP:0000575)2.07457229
114Hyperaldosteronism (HP:0000859)2.04631845
115Absent speech (HP:0001344)2.04069309
116Bradykinesia (HP:0002067)2.03442185
117Stomach cancer (HP:0012126)2.01759868
118Protruding tongue (HP:0010808)2.01232204
119Sclerocornea (HP:0000647)2.00618051
120Generalized myoclonic seizures (HP:0002123)1.99620031
121Hypoplasia of the pons (HP:0012110)1.98911521
122Abnormality of chloride homeostasis (HP:0011422)1.98532714
123Congenital sensorineural hearing impairment (HP:0008527)1.98155995
124Pendular nystagmus (HP:0012043)1.97605778
125Retinal dysplasia (HP:0007973)1.97386767
126Furrowed tongue (HP:0000221)1.96895510
127Vaginal atresia (HP:0000148)1.96707543
128Tetany (HP:0001281)1.95825799
129Abnormality of calcium-phosphate metabolism (HP:0100530)1.95019885
130Genetic anticipation (HP:0003743)1.93572435
131Metaphyseal dysplasia (HP:0100255)1.93102534
132Keratoconus (HP:0000563)1.91616743
133Increased corneal curvature (HP:0100692)1.91616743
134Megalencephaly (HP:0001355)1.91538433
135Abnormality of the pons (HP:0007361)1.91026092
136Stereotypic behavior (HP:0000733)1.89060844
137Congenital hepatic fibrosis (HP:0002612)1.87581889
138Impaired smooth pursuit (HP:0007772)1.86765605
139Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86040655
140Abnormality of alanine metabolism (HP:0010916)1.86040655
141Hyperalaninemia (HP:0003348)1.86040655
142Widely spaced teeth (HP:0000687)1.84500605
143Amyotrophic lateral sclerosis (HP:0007354)1.83333304
144Aplasia/Hypoplasia of the macula (HP:0008059)1.82365602
145Median cleft lip (HP:0000161)1.82238458
146Postaxial hand polydactyly (HP:0001162)1.80856379
147Akinesia (HP:0002304)1.79541082
148Psychosis (HP:0000709)1.79332741
149Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.79313530
150Incomplete penetrance (HP:0003829)1.79279007
151Lower limb muscle weakness (HP:0007340)1.79264612
152Abnormality of binocular vision (HP:0011514)1.79139272
153Diplopia (HP:0000651)1.79139272
154Hypothermia (HP:0002045)1.77811293
155Ulnar claw (HP:0001178)1.77517430
156Postaxial foot polydactyly (HP:0001830)1.77383531
157Optic nerve hypoplasia (HP:0000609)1.77139977
158Generalized hypopigmentation of hair (HP:0011358)1.76027765
159Decreased circulating renin level (HP:0003351)1.74052158
160Specific learning disability (HP:0001328)1.73127546
161Impaired vibratory sensation (HP:0002495)1.72608933
162Nephrogenic diabetes insipidus (HP:0009806)1.72248624
163Congenital primary aphakia (HP:0007707)1.71788171
164Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.71668552
165Small hand (HP:0200055)1.71495197
166Dynein arm defect of respiratory motile cilia (HP:0012255)1.71020488
167Absent/shortened dynein arms (HP:0200106)1.71020488
168Medial flaring of the eyebrow (HP:0010747)1.70601746
169Astigmatism (HP:0000483)1.70310058
170Anencephaly (HP:0002323)1.69907987

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.86080335
2MARK13.99415069
3NTRK33.90235537
4EPHA43.73560070
5MAP3K93.49224182
6MAP3K43.00102789
7TAF12.76496562
8MINK12.65388299
9MAP2K72.63068814
10ADRBK22.61993881
11BMPR1B2.39311321
12NTRK22.26397195
13KSR22.20046924
14MAP4K22.15621805
15OXSR12.15144069
16CASK2.14867745
17WNK42.12770723
18WNK32.03169345
19DAPK21.99891925
20MAP3K121.95276691
21GRK11.90204008
22KSR11.88737245
23PAK61.82987568
24MAP2K41.81785875
25TAOK31.81764820
26NTRK11.76152859
27MAPK131.69772807
28ACVR1B1.67210906
29LATS21.66023400
30PRKD31.65267689
31PNCK1.62384704
32ARAF1.57562220
33TNIK1.51220063
34STK381.47205559
35CDK51.38656844
36ZAK1.32530563
37INSRR1.31782197
38PLK21.30247680
39TRIM281.28503954
40DAPK11.26474406
41STK391.25067771
42PHKG21.24200547
43PHKG11.24200547
44GRK51.19308439
45PRKCG1.16666702
46RIPK41.15394548
47CAMKK11.12857672
48SGK2231.12081356
49SGK4941.12081356
50MAP3K61.08175887
51TLK11.04769038
52NUAK11.03168336
53CAMK2A1.02687952
54CDK191.01837911
55CSNK1G21.01708673
56MAP3K20.98220794
57NME10.95009562
58NEK10.94302179
59MUSK0.93659626
60ADRBK10.93334585
61BMPR20.92742697
62MAP3K130.92193269
63MKNK20.90608492
64UHMK10.88087545
65MAPK150.85529325
66STK38L0.85071649
67CDK180.84712434
68PINK10.84258903
69SIK20.82452321
70TAOK10.82372178
71PAK30.81728542
72CDK140.81428915
73DYRK20.81023150
74CDK150.79637600
75BRAF0.78667112
76RAF10.78525169
77PRPF4B0.78183038
78SGK20.76501242
79PRKCQ0.74926088
80CAMKK20.74436776
81STK110.73813404
82DYRK1A0.73314677
83MARK20.72348255
84CAMK2B0.72309898
85RET0.70921598
86PIK3CA0.68536135
87CDK11A0.67815749
88SGK10.67347789
89PDK30.65893620
90PDK40.65893620
91PTK2B0.65779716
92FES0.65299431
93MAPK120.64753683
94TYRO30.63264519
95WNK10.59409180
96MAPKAPK30.59157855
97CCNB10.59001318
98SIK30.57773914
99CAMK10.56607110
100PRKCZ0.55011996
101TIE10.54461506
102PRKG10.52954279
103PRKCI0.51274026
104MARK30.51179498
105FER0.51162530
106CSNK1G30.50769982
107MAPKAPK50.50283963
108TXK0.48867750
109SGK30.47728495
110TRPM70.47302713
111PRKCE0.46233233
112STK30.45264244
113MST40.45071550
114LMTK20.44879813
115BCR0.43483771
116ERBB30.42030670
117CSNK1A10.41434094
118MAP3K10.41231565
119STK240.40953552
120FGFR20.39906004
121PDPK10.39464322
122PRKD10.39456565
123PDK10.39230251
124KIT0.38629199
125IKBKB0.37563088
126MAPK70.37551824
127RPS6KA30.36903514
128CAMK2G0.36361949
129MAP2K10.35966138
130TGFBR10.35765279
131PRKCA0.35377668
132CDK30.35299745
133CAMK2D0.34278705
134MAPK100.34197194
135PRKCH0.33853565
136PRKACA0.33824307
137BCKDK0.32701208
138PKN10.31448884
139IGF1R0.30863931
140RPS6KB10.30810604
141CSNK1G10.29760927
142PRKACB0.29505411
143CSNK1A1L0.29400667
144STK160.29397564
145CSNK1D0.29080871

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.86875437
2Synaptic vesicle cycle_Homo sapiens_hsa047213.34543226
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.66996915
4GABAergic synapse_Homo sapiens_hsa047272.63528335
5Circadian entrainment_Homo sapiens_hsa047132.60472238
6Long-term potentiation_Homo sapiens_hsa047202.54831166
7Nitrogen metabolism_Homo sapiens_hsa009102.53481990
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.52617551
9Glutamatergic synapse_Homo sapiens_hsa047242.51985240
10Olfactory transduction_Homo sapiens_hsa047402.50821800
11Morphine addiction_Homo sapiens_hsa050322.45223283
12Amphetamine addiction_Homo sapiens_hsa050312.38242141
13Dopaminergic synapse_Homo sapiens_hsa047282.17137697
14Collecting duct acid secretion_Homo sapiens_hsa049662.09115239
15Insulin secretion_Homo sapiens_hsa049112.01160318
16Linoleic acid metabolism_Homo sapiens_hsa005911.99343520
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.98378844
18Salivary secretion_Homo sapiens_hsa049701.98090988
19Taste transduction_Homo sapiens_hsa047421.94022763
20Serotonergic synapse_Homo sapiens_hsa047261.93729911
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.81256241
22Cholinergic synapse_Homo sapiens_hsa047251.80798676
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75015176
24Gastric acid secretion_Homo sapiens_hsa049711.74553772
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.68289954
26Long-term depression_Homo sapiens_hsa047301.67705563
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66317394
28Cocaine addiction_Homo sapiens_hsa050301.62831183
29Renin secretion_Homo sapiens_hsa049241.58616131
30ABC transporters_Homo sapiens_hsa020101.57671268
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53751128
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53446183
33Tryptophan metabolism_Homo sapiens_hsa003801.52296868
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.49936780
35Selenocompound metabolism_Homo sapiens_hsa004501.49467374
36Oxytocin signaling pathway_Homo sapiens_hsa049211.45954424
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45207677
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42786227
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41585440
40Calcium signaling pathway_Homo sapiens_hsa040201.41416039
41Caffeine metabolism_Homo sapiens_hsa002321.35092525
42Ether lipid metabolism_Homo sapiens_hsa005651.34802495
43Gap junction_Homo sapiens_hsa045401.34002311
44GnRH signaling pathway_Homo sapiens_hsa049121.30806750
45Cardiac muscle contraction_Homo sapiens_hsa042601.23246365
46Butanoate metabolism_Homo sapiens_hsa006501.22135014
47Basal transcription factors_Homo sapiens_hsa030221.19376213
48cAMP signaling pathway_Homo sapiens_hsa040241.14857306
49Intestinal immune network for IgA production_Homo sapiens_hsa046721.14747540
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13007738
51beta-Alanine metabolism_Homo sapiens_hsa004101.11447185
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10289124
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09834474
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09598641
55Axon guidance_Homo sapiens_hsa043601.08003539
56Oxidative phosphorylation_Homo sapiens_hsa001901.05095990
57Vibrio cholerae infection_Homo sapiens_hsa051101.04383625
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04056759
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.99765817
60Oocyte meiosis_Homo sapiens_hsa041140.99091810
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98806486
62Homologous recombination_Homo sapiens_hsa034400.98506735
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.97911967
64Phototransduction_Homo sapiens_hsa047440.96895518
65Estrogen signaling pathway_Homo sapiens_hsa049150.96083478
66Type II diabetes mellitus_Homo sapiens_hsa049300.94568491
67Alzheimers disease_Homo sapiens_hsa050100.92996590
68Glioma_Homo sapiens_hsa052140.90941323
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90197658
70Histidine metabolism_Homo sapiens_hsa003400.88150394
71ErbB signaling pathway_Homo sapiens_hsa040120.87894271
72Melanogenesis_Homo sapiens_hsa049160.87718580
73Parkinsons disease_Homo sapiens_hsa050120.86468862
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86214065
75Choline metabolism in cancer_Homo sapiens_hsa052310.85392135
76Retinol metabolism_Homo sapiens_hsa008300.84896958
77Chemical carcinogenesis_Homo sapiens_hsa052040.83751754
78Protein export_Homo sapiens_hsa030600.83728028
79Dorso-ventral axis formation_Homo sapiens_hsa043200.82198533
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.80095405
81Peroxisome_Homo sapiens_hsa041460.77311397
82Pancreatic secretion_Homo sapiens_hsa049720.74959278
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73978427
84Thyroid hormone synthesis_Homo sapiens_hsa049180.73656109
85Sphingolipid metabolism_Homo sapiens_hsa006000.71835063
86Glycerolipid metabolism_Homo sapiens_hsa005610.71739079
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71525853
88Circadian rhythm_Homo sapiens_hsa047100.67417275
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65030976
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.63913144
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63186076
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62421847
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62349504
94Type I diabetes mellitus_Homo sapiens_hsa049400.62279469
95Huntingtons disease_Homo sapiens_hsa050160.61716824
96Bile secretion_Homo sapiens_hsa049760.61386042
97Fanconi anemia pathway_Homo sapiens_hsa034600.58502267
98Ovarian steroidogenesis_Homo sapiens_hsa049130.57376518
99Glucagon signaling pathway_Homo sapiens_hsa049220.56521727
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55900206
101Ras signaling pathway_Homo sapiens_hsa040140.53189758
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52340059
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.52271129
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51109079
105Lysine degradation_Homo sapiens_hsa003100.50778706
106Pyruvate metabolism_Homo sapiens_hsa006200.50017848
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49715447
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48933171
109Regulation of autophagy_Homo sapiens_hsa041400.48833598
110Arachidonic acid metabolism_Homo sapiens_hsa005900.47286599
111Alcoholism_Homo sapiens_hsa050340.46897261
112MAPK signaling pathway_Homo sapiens_hsa040100.45974808
113Inositol phosphate metabolism_Homo sapiens_hsa005620.45474257
114Asthma_Homo sapiens_hsa053100.43661135
115VEGF signaling pathway_Homo sapiens_hsa043700.42695994
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42138576
117Endometrial cancer_Homo sapiens_hsa052130.41692674
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41457923
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40772243
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40029743
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38369860
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37964441
123Graft-versus-host disease_Homo sapiens_hsa053320.37317794
124Purine metabolism_Homo sapiens_hsa002300.36668215
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.35847287
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35338145
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35226545
128Rap1 signaling pathway_Homo sapiens_hsa040150.35157489
129Dilated cardiomyopathy_Homo sapiens_hsa054140.34505055
130Fat digestion and absorption_Homo sapiens_hsa049750.33856203
131Mineral absorption_Homo sapiens_hsa049780.33507810
132Primary immunodeficiency_Homo sapiens_hsa053400.32889159
133RNA degradation_Homo sapiens_hsa030180.32840780
134Insulin signaling pathway_Homo sapiens_hsa049100.32544266
135Wnt signaling pathway_Homo sapiens_hsa043100.32383923
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32196416
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32151406
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31437077
139Renal cell carcinoma_Homo sapiens_hsa052110.29612473
140mTOR signaling pathway_Homo sapiens_hsa041500.29262355
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.27185446
142Propanoate metabolism_Homo sapiens_hsa006400.26758992
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25787219
144Endocytosis_Homo sapiens_hsa041440.22589775

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