MAD1L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.15395455
2DNA unwinding involved in DNA replication (GO:0006268)5.07295213
3DNA strand elongation involved in DNA replication (GO:0006271)5.00190635
4DNA strand elongation (GO:0022616)4.74908726
5DNA replication initiation (GO:0006270)4.72213846
6telomere maintenance via semi-conservative replication (GO:0032201)4.65765629
7NIK/NF-kappaB signaling (GO:0038061)4.39502125
8positive regulation of gamma-delta T cell activation (GO:0046645)4.34849266
9mitotic sister chromatid segregation (GO:0000070)4.32126082
10protein localization to chromosome, centromeric region (GO:0071459)4.26831004
11telomere maintenance via recombination (GO:0000722)4.18030336
12mitotic nuclear envelope disassembly (GO:0007077)4.13870666
13formation of translation preinitiation complex (GO:0001731)4.12333753
14DNA replication-dependent nucleosome assembly (GO:0006335)4.08864121
15DNA replication-dependent nucleosome organization (GO:0034723)4.08864121
16positive thymic T cell selection (GO:0045059)4.07847246
17mitotic recombination (GO:0006312)4.03139992
18folic acid-containing compound biosynthetic process (GO:0009396)3.98421918
19sister chromatid segregation (GO:0000819)3.97478503
20regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.91532541
21mitotic chromosome condensation (GO:0007076)3.91213410
22nucleobase biosynthetic process (GO:0046112)3.85650347
23membrane disassembly (GO:0030397)3.82030881
24nuclear envelope disassembly (GO:0051081)3.82030881
25DNA replication checkpoint (GO:0000076)3.81299008
26mitotic metaphase plate congression (GO:0007080)3.80861223
27nucleotide-excision repair, DNA gap filling (GO:0006297)3.80236604
28nuclear pore organization (GO:0006999)3.73795768
29telomere maintenance via telomere lengthening (GO:0010833)3.69726588
30negative T cell selection (GO:0043383)3.69003426
31IMP biosynthetic process (GO:0006188)3.68266696
32regulation of spindle organization (GO:0090224)3.65809643
33thymic T cell selection (GO:0045061)3.64913993
34DNA duplex unwinding (GO:0032508)3.62185660
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.61567588
36DNA geometric change (GO:0032392)3.60917799
37negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.60187943
38negative thymic T cell selection (GO:0045060)3.60141236
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.59947988
40positive regulation of chromosome segregation (GO:0051984)3.59922279
41antigen processing and presentation of endogenous antigen (GO:0019883)3.59299318
42somatic hypermutation of immunoglobulin genes (GO:0016446)3.58262601
43somatic diversification of immune receptors via somatic mutation (GO:0002566)3.58262601
44Arp2/3 complex-mediated actin nucleation (GO:0034314)3.55765388
45immunoglobulin mediated immune response (GO:0016064)3.55560256
46nuclear pore complex assembly (GO:0051292)3.52031466
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.48062128
48positive T cell selection (GO:0043368)3.47312685
49kinetochore organization (GO:0051383)3.46412093
50DNA deamination (GO:0045006)3.45866816
51regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.41209544
52negative regulation of cell killing (GO:0031342)3.39780637
53negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.39780637
54pinocytosis (GO:0006907)3.38211246
55regulation of gamma-delta T cell differentiation (GO:0045586)3.34967077
56attachment of spindle microtubules to kinetochore (GO:0008608)3.34770472
57IMP metabolic process (GO:0046040)3.33891096
58CENP-A containing nucleosome assembly (GO:0034080)3.32660685
59positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.32570853
60purine nucleobase biosynthetic process (GO:0009113)3.32192405
61base-excision repair (GO:0006284)3.31439178
62regulation of gamma-delta T cell activation (GO:0046643)3.30162608
63T cell selection (GO:0045058)3.29697632
64regulation of defense response to virus by virus (GO:0050690)3.28293725
65metaphase plate congression (GO:0051310)3.27892381
66chromatin remodeling at centromere (GO:0031055)3.26365562
67* negative regulation of chromosome segregation (GO:0051985)3.24543311
68negative regulation of RNA splicing (GO:0033119)3.23289206
69antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.21376934
70ribosome assembly (GO:0042255)3.20257926
71* regulation of chromosome segregation (GO:0051983)3.19768343
72positive regulation by symbiont of host defense response (GO:0052509)3.19674404
73modulation by symbiont of host defense response (GO:0052031)3.19674404
74modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.19674404
75modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.19674404
76positive regulation by organism of defense response of other organism involved in symbiotic interact3.19674404
77modulation by symbiont of host immune response (GO:0052553)3.19674404
78mismatch repair (GO:0006298)3.19405772
79nuclear envelope organization (GO:0006998)3.19063691
80ribosome biogenesis (GO:0042254)3.18867030
81regulation of translational fidelity (GO:0006450)3.17326397
82regulation of type I interferon-mediated signaling pathway (GO:0060338)3.16902644
83DNA replication-independent nucleosome assembly (GO:0006336)3.16059210
84DNA replication-independent nucleosome organization (GO:0034724)3.16059210
85regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.13928014
86positive regulation of B cell differentiation (GO:0045579)3.13059534
87establishment of chromosome localization (GO:0051303)3.13033285
88regulation of double-strand break repair via homologous recombination (GO:0010569)3.12236261
89positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.11407130
90dosage compensation (GO:0007549)3.11119797
91* spindle checkpoint (GO:0031577)3.09682607
92kinetochore assembly (GO:0051382)3.09261937
93response to muramyl dipeptide (GO:0032495)3.09053361
94maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.08975640
95* negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.08115366
96* negative regulation of sister chromatid segregation (GO:0033046)3.08115366
97* negative regulation of mitotic sister chromatid separation (GO:2000816)3.08115366
98* negative regulation of mitotic sister chromatid segregation (GO:0033048)3.08115366
99negative regulation of mRNA processing (GO:0050686)3.07787722
100regulation of centrosome cycle (GO:0046605)3.06241751
101spliceosomal tri-snRNP complex assembly (GO:0000244)3.05870044
102* spindle assembly checkpoint (GO:0071173)3.05247800
103spliceosomal snRNP assembly (GO:0000387)3.04830687
104response to peptidoglycan (GO:0032494)3.03057323
105T cell migration (GO:0072678)3.02979046
106DNA conformation change (GO:0071103)3.02798463
107* mitotic spindle assembly checkpoint (GO:0007094)3.01571535
108negative regulation of erythrocyte differentiation (GO:0045647)3.01215561
109positive regulation of mitotic sister chromatid separation (GO:1901970)3.00133836
110positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.00133836
111positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.00133836
112regulation of mitotic spindle organization (GO:0060236)2.99704014
113* negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.99229311
114telomere organization (GO:0032200)2.98721088
115* regulation of mitotic metaphase/anaphase transition (GO:0030071)2.98000614
116chromatin assembly or disassembly (GO:0006333)2.97476241
117maturation of SSU-rRNA (GO:0030490)2.95947536
118chromosome segregation (GO:0007059)2.95825596
119telomere maintenance (GO:0000723)2.95341764
120GDP-mannose metabolic process (GO:0019673)2.94877468
121type I interferon signaling pathway (GO:0060337)2.94165935
122cellular response to type I interferon (GO:0071357)2.94165935
123protein localization to chromosome (GO:0034502)2.93978291
124regulation of translational termination (GO:0006449)2.93860327
125negative regulation of interleukin-12 production (GO:0032695)2.92952969
126mitotic G1 DNA damage checkpoint (GO:0031571)2.91806399
127* regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.91416310
128* mitotic spindle checkpoint (GO:0071174)2.91404002
129meiotic chromosome segregation (GO:0045132)2.91063282
130replication fork processing (GO:0031297)2.90761751
131response to type I interferon (GO:0034340)2.90758489
132leukocyte aggregation (GO:0070486)2.90740612
133regulation of histone H3-K9 methylation (GO:0051570)2.90623113
134negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.89592079
135translesion synthesis (GO:0019985)2.88699042
136actin nucleation (GO:0045010)2.88096766
137regulation of B cell receptor signaling pathway (GO:0050855)2.86766489
138regulation of sister chromatid cohesion (GO:0007063)2.86592292
139pore complex assembly (GO:0046931)2.86541418
140* regulation of mitotic sister chromatid separation (GO:0010965)2.84745863
141* regulation of mitotic sister chromatid segregation (GO:0033047)2.84745863
142* regulation of sister chromatid segregation (GO:0033045)2.84745863
143chromosome condensation (GO:0030261)2.82925904
144negative regulation of B cell apoptotic process (GO:0002903)2.82333105
145cell cycle G1/S phase transition (GO:0044843)2.81156552
146G1/S transition of mitotic cell cycle (GO:0000082)2.81156552
147B cell receptor signaling pathway (GO:0050853)2.80103132
148positive regulation of antigen processing and presentation (GO:0002579)2.76080849
149regulation of interferon-beta biosynthetic process (GO:0045357)2.74519506
150amino sugar catabolic process (GO:0046348)2.73390102
151neutrophil activation involved in immune response (GO:0002283)2.73115191
152natural killer cell differentiation (GO:0001779)2.69426439
153antigen processing and presentation via MHC class Ib (GO:0002475)2.68131909
154negative regulation of DNA-templated transcription, elongation (GO:0032785)2.67013359
155detection of bacterium (GO:0016045)2.66019446
1563-UTR-mediated mRNA stabilization (GO:0070935)2.65120921
157cellular response to virus (GO:0098586)2.64423851
158negative regulation of myeloid cell apoptotic process (GO:0033033)2.63261108
159detection of other organism (GO:0098543)2.61928549
160interferon-gamma-mediated signaling pathway (GO:0060333)2.61141224
161modulation by virus of host process (GO:0019054)2.57436809
162regulation of interleukin-2 biosynthetic process (GO:0045076)2.57366632
163regulation of antigen processing and presentation (GO:0002577)2.56046658
164pyrimidine nucleoside salvage (GO:0043097)2.55353214
165pyrimidine-containing compound salvage (GO:0008655)2.55353214
166regulation of mast cell degranulation (GO:0043304)2.55206611
167purine deoxyribonucleotide catabolic process (GO:0009155)2.55128224
168B cell mediated immunity (GO:0019724)2.54066831
169mature B cell differentiation involved in immune response (GO:0002313)2.49440090
170macrophage activation involved in immune response (GO:0002281)2.48983329
171peptidyl-arginine omega-N-methylation (GO:0035247)2.48929583
172Peyers patch development (GO:0048541)2.48705161
173mucosal-associated lymphoid tissue development (GO:0048537)2.48705161
174barbed-end actin filament capping (GO:0051016)2.47133575
175regulation of B cell differentiation (GO:0045577)2.46475788
176modulation by symbiont of host cellular process (GO:0044068)2.45931076
177nucleotide salvage (GO:0043173)2.45331243
178regulation of mammary gland epithelial cell proliferation (GO:0033599)2.45157924
179myeloid dendritic cell activation (GO:0001773)2.43726330
180lipopolysaccharide-mediated signaling pathway (GO:0031663)2.43020590
181respiratory burst (GO:0045730)2.42487236
182negative regulation of innate immune response (GO:0045824)2.40695338
183T cell costimulation (GO:0031295)2.40639607
184T cell receptor signaling pathway (GO:0050852)2.40375507
185regulation of B cell apoptotic process (GO:0002902)2.38103576
186myeloid dendritic cell differentiation (GO:0043011)2.37626121
187mannose metabolic process (GO:0006013)2.36452481
188regulation of leukocyte degranulation (GO:0043300)2.36146218
189antigen receptor-mediated signaling pathway (GO:0050851)2.35467633
190lymphocyte costimulation (GO:0031294)2.35456307
191myeloid cell activation involved in immune response (GO:0002275)2.34311666
192protein localization to endosome (GO:0036010)2.34140130
193cellular response to interleukin-4 (GO:0071353)2.33697005
194regulation of mast cell activation involved in immune response (GO:0033006)2.31505817
195intracellular estrogen receptor signaling pathway (GO:0030520)2.30165449
196leukocyte degranulation (GO:0043299)2.30063898
197regulation of dendritic cell antigen processing and presentation (GO:0002604)2.29879351
198negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.29566355
199negative regulation of leukocyte mediated immunity (GO:0002704)2.28892942

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.66753379
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.68060991
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.76369659
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.63112326
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.49324842
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.17023176
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.79295866
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.73876857
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55776014
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54545681
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.48832070
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.34775174
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.33119432
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.30274404
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.27448820
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22709264
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15501461
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14477850
19AR_21909140_ChIP-Seq_LNCAP_Human2.08468699
20* LXR_22292898_ChIP-Seq_THP-1_Human2.08017799
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07904162
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.07708904
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.07023218
24MAF_26560356_Chip-Seq_TH1_Human2.06279504
25* XRN2_22483619_ChIP-Seq_HELA_Human2.05378254
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.00518532
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.98960495
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.98934738
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.97767057
30* MYC_22102868_ChIP-Seq_BL_Human1.97644181
31VDR_24763502_ChIP-Seq_THP-1_Human1.91396910
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.90318038
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88808049
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88608291
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85768756
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83344859
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82976450
38MAF_26560356_Chip-Seq_TH2_Human1.79496715
39VDR_23849224_ChIP-Seq_CD4+_Human1.78867824
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.77793696
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76027712
42KDM2B_26808549_Chip-Seq_DND41_Human1.74228655
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.73296265
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72455642
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72108862
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71771946
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71666055
48TCF7_22412390_ChIP-Seq_EML_Mouse1.70766760
49* GABP_19822575_ChIP-Seq_HepG2_Human1.69530981
50DCP1A_22483619_ChIP-Seq_HELA_Human1.66931244
51FOXP3_21729870_ChIP-Seq_TREG_Human1.66372628
52SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.63647106
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.60909425
54* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60471056
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59461299
56VDR_21846776_ChIP-Seq_THP-1_Human1.58876591
57* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.58835439
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57043759
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56777586
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56726877
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56459883
62CIITA_25753668_ChIP-Seq_RAJI_Human1.55351164
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.53986171
64TTF2_22483619_ChIP-Seq_HELA_Human1.52155066
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50719296
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.50518031
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50314124
68KDM5A_27292631_Chip-Seq_BREAST_Human1.50226569
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.47789245
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47550473
71NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47163456
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42641495
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41957271
74BCL6_27268052_Chip-Seq_Bcells_Human1.41727857
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40845663
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.38262941
77P68_20966046_ChIP-Seq_HELA_Human1.38143347
78TFEB_21752829_ChIP-Seq_HELA_Human1.38087358
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37008311
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36330392
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35778076
82MYB_26560356_Chip-Seq_TH1_Human1.35668986
83MYB_26560356_Chip-Seq_TH2_Human1.35428936
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35203562
85* BCOR_27268052_Chip-Seq_Bcells_Human1.35015936
86RACK7_27058665_Chip-Seq_MCF-7_Human1.33668586
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33176932
88YY1_21170310_ChIP-Seq_MESCs_Mouse1.32074163
89* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31998578
90* SCL_19346495_ChIP-Seq_HPC-7_Human1.30746271
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30480482
92CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30449930
93RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30367154
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28825957
95SPI1_23127762_ChIP-Seq_K562_Human1.27174810
96* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27110275
97NCOR1_26117541_ChIP-Seq_K562_Human1.25836780
98PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25194426
99* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24304337
100* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23508251
101SA1_27219007_Chip-Seq_ERYTHROID_Human1.22413714
102ELK1_19687146_ChIP-ChIP_HELA_Human1.22029286
103PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21910191
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21732475
105SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21204842
106IRF8_27001747_Chip-Seq_BMDM_Mouse1.18729228
107GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17410734
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16904861
109VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16588750
110SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16446988
111FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16144592
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15515852
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15499322
114KDM2B_26808549_Chip-Seq_JURKAT_Human1.14469363
115CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13981490
116* SRF_21415370_ChIP-Seq_HL-1_Mouse1.10451843
117PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09848697
118GATA1_19941827_ChIP-Seq_MEL_Mouse1.09653405
119STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09304756
120SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08198714
121ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08064874
122MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07347577
123* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06013804
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05550982
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04359016
126CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03354103
127* TP53_22127205_ChIP-Seq_IMR90_Human1.03054420
128ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02916448
129RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02873715
130CTCF_26484167_Chip-Seq_Bcells_Mouse1.02749971
131GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02605273
132SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02052514
133FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01959952
134ETS1_21867929_ChIP-Seq_TH2_Mouse1.01334077
135POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01019068
136NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00621092
137NANOG_21062744_ChIP-ChIP_HESCs_Human1.00319294
138UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00199814
139SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97591117
140BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94193557
141HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93980031
142FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90845576
143CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90807802
144TP63_19390658_ChIP-ChIP_HaCaT_Human0.90771228
145NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89876366
146PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89293411
147DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85898776
148* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84621210
149GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84494586
150TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83746369
151SPI1_23547873_ChIP-Seq_NB4_Human0.82802189
152UTX_26944678_Chip-Seq_JUKART_Human0.81930278
153ELK3_25401928_ChIP-Seq_HUVEC_Human0.81851617
154* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80759526
155PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.78055934
156NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.77678669
157* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77062915
158KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.76123848
159KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.76123848
160KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.76123848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.70543081
2MP0010094_abnormal_chromosome_stability4.61706269
3* MP0003111_abnormal_nucleus_morphology4.37758502
4MP0004957_abnormal_blastocyst_morpholog3.96320299
5MP0008057_abnormal_DNA_replication3.88457804
6* MP0003077_abnormal_cell_cycle3.87685346
7MP0005058_abnormal_lysosome_morphology3.60316991
8MP0005451_abnormal_body_composition3.40848595
9MP0005671_abnormal_response_to3.00844091
10MP0003436_decreased_susceptibility_to2.95671025
11MP0008058_abnormal_DNA_repair2.93382331
12MP0010352_gastrointestinal_tract_polyps2.83974898
13MP0001835_abnormal_antigen_presentation2.70052004
14MP0008007_abnormal_cellular_replicative2.63160992
15MP0008932_abnormal_embryonic_tissue2.60028039
16MP0008260_abnormal_autophagy2.47538258
17MP0001730_embryonic_growth_arrest2.45033286
18MP0009840_abnormal_foam_cell2.41993043
19MP0002396_abnormal_hematopoietic_system2.40811522
20MP0005000_abnormal_immune_tolerance2.26598346
21MP0002419_abnormal_innate_immunity2.24518192
22MP0003172_abnormal_lysosome_physiology2.22516700
23MP0003303_peritoneal_inflammation2.20302465
24MP0000685_abnormal_immune_system2.19975549
25MP0005025_abnormal_response_to2.19414002
26MP0000350_abnormal_cell_proliferation2.18889292
27MP0002138_abnormal_hepatobiliary_system2.12264678
28MP0001800_abnormal_humoral_immune2.11228865
29MP0002452_abnormal_antigen_presenting2.09741843
30MP0002420_abnormal_adaptive_immunity2.09181849
31MP0001819_abnormal_immune_cell2.06266477
32MP0010307_abnormal_tumor_latency2.04988119
33MP0003705_abnormal_hypodermis_morpholog2.03573748
34MP0002723_abnormal_immune_serum2.02761338
35MP0002148_abnormal_hypersensitivity_rea1.92329799
36MP0009785_altered_susceptibility_to1.81501011
37MP0005387_immune_system_phenotype1.80683200
38MP0001790_abnormal_immune_system1.80683200
39MP0009278_abnormal_bone_marrow1.80462930
40MP0001697_abnormal_embryo_size1.80425178
41MP0001672_abnormal_embryogenesis/_devel1.77746437
42MP0005380_embryogenesis_phenotype1.77746437
43MP0006082_CNS_inflammation1.76034371
44MP0005464_abnormal_platelet_physiology1.75814738
45MP0004947_skin_inflammation1.71492191
46MP0003786_premature_aging1.71059582
47MP0004381_abnormal_hair_follicle1.68719553
48MP0005076_abnormal_cell_differentiation1.67684414
49* MP0002080_prenatal_lethality1.67511401
50MP0000490_abnormal_crypts_of1.66892974
51MP0008877_abnormal_DNA_methylation1.64139234
52MP0002085_abnormal_embryonic_tissue1.62882466
53MP0010030_abnormal_orbit_morphology1.58351863
54MP0003984_embryonic_growth_retardation1.57649691
55MP0002084_abnormal_developmental_patter1.57428292
56MP0004197_abnormal_fetal_growth/weight/1.56439595
57MP0003806_abnormal_nucleotide_metabolis1.55394604
58MP0002086_abnormal_extraembryonic_tissu1.54220323
59MP0000015_abnormal_ear_pigmentation1.53848651
60MP0002088_abnormal_embryonic_growth/wei1.53002734
61* MP0002019_abnormal_tumor_incidence1.52538393
62MP0003123_paternal_imprinting1.49597644
63MP0001545_abnormal_hematopoietic_system1.49187119
64MP0005397_hematopoietic_system_phenotyp1.49187119
65MP0000604_amyloidosis1.47723807
66MP0001348_abnormal_lacrimal_gland1.39972425
67MP0003300_gastrointestinal_ulcer1.38691906
68MP0000313_abnormal_cell_death1.38293606
69MP0004510_myositis1.37499636
70MP0001533_abnormal_skeleton_physiology1.37166118
71MP0004808_abnormal_hematopoietic_stem1.36872652
72MP0005023_abnormal_wound_healing1.32755284
73MP0001853_heart_inflammation1.31975338
74MP0006054_spinal_hemorrhage1.27122282
75MP0003566_abnormal_cell_adhesion1.26905445
76MP0001845_abnormal_inflammatory_respons1.25476434
77MP0003718_maternal_effect1.23494231
78MP0000703_abnormal_thymus_morphology1.19437061
79MP0009333_abnormal_splenocyte_physiolog1.19068056
80MP0002254_reproductive_system_inflammat1.18586693
81MP0001293_anophthalmia1.17003155
82MP0000537_abnormal_urethra_morphology1.16989434
83MP0003890_abnormal_embryonic-extraembry1.16123264
84MP0003329_amyloid_beta_deposits1.15740597
85MP0003724_increased_susceptibility_to1.15213220
86MP0002998_abnormal_bone_remodeling1.14712276
87MP0003191_abnormal_cellular_cholesterol1.13243984
88MP0003075_altered_response_to1.10408110
89MP0003091_abnormal_cell_migration1.10287170
90MP0008438_abnormal_cutaneous_collagen1.10093582
91MP0003763_abnormal_thymus_physiology1.07798562
92MP0001849_ear_inflammation1.07398889
93MP0008469_abnormal_protein_level1.07049740
94MP0010155_abnormal_intestine_physiology1.06654856
95MP0009053_abnormal_anal_canal1.05878644
96MP0001873_stomach_inflammation1.05746926
97MP0002722_abnormal_immune_system1.02412646
98MP0000358_abnormal_cell_content/1.02175738
99MP0002398_abnormal_bone_marrow1.02066930
100MP0000372_irregular_coat_pigmentation1.01379766
101MP0002089_abnormal_postnatal_growth/wei1.01211000
102MP0005257_abnormal_intraocular_pressure1.00286798
103MP0005171_absent_coat_pigmentation1.00260102
104MP0003866_abnormal_defecation0.98350865
105MP0001915_intracranial_hemorrhage0.98139429
106MP0002111_abnormal_tail_morphology0.98070224
107MP0000858_altered_metastatic_potential0.97977909
108MP0002653_abnormal_ependyma_morphology0.96832610
109MP0003121_genomic_imprinting0.96446534
110MP0000689_abnormal_spleen_morphology0.96390203
111MP0005310_abnormal_salivary_gland0.94411537
112MP0002210_abnormal_sex_determination0.93307913
113* MP0005621_abnormal_cell_physiology0.91373266
114* MP0005384_cellular_phenotype0.90349339
115MP0003567_abnormal_fetal_cardiomyocyte0.88661382
116MP0009764_decreased_sensitivity_to0.88262600
117MP0008961_abnormal_basal_metabolism0.87510760
118MP0001145_abnormal_male_reproductive0.86760527
119MP0000371_diluted_coat_color0.86515868
120MP0003656_abnormal_erythrocyte_physiolo0.85994627
121MP0004233_abnormal_muscle_weight0.82965435
122MP0004185_abnormal_adipocyte_glucose0.82825885
123MP0000733_abnormal_muscle_development0.82149330
124MP0000343_altered_response_to0.79359051
125MP0002429_abnormal_blood_cell0.78933806
126MP0004133_heterotaxia0.78107822
127MP0002092_abnormal_eye_morphology0.78074486
128MP0005075_abnormal_melanosome_morpholog0.77977109
129MP0002269_muscular_atrophy0.76995396
130MP0002332_abnormal_exercise_endurance0.76610442
131MP0002877_abnormal_melanocyte_morpholog0.76372697
132MP0001929_abnormal_gametogenesis0.74054713
133MP0001851_eye_inflammation0.73673999
134MP0003119_abnormal_digestive_system0.73590611
135MP0004858_abnormal_nervous_system0.73388273
136MP0002132_abnormal_respiratory_system0.73360004
137MP0009672_abnormal_birth_weight0.72784659
138MP0009703_decreased_birth_body0.72066700
139MP0001243_abnormal_dermal_layer0.71573712
140MP0000428_abnormal_craniofacial_morphol0.70244733
141MP0003221_abnormal_cardiomyocyte_apopto0.70081586
142MP0000477_abnormal_intestine_morphology0.68348826
143MP0008770_decreased_survivor_rate0.67871525
144MP0000653_abnormal_sex_gland0.66787220
145MP0002075_abnormal_coat/hair_pigmentati0.64399791
146MP0000716_abnormal_immune_system0.63094534
147MP0003453_abnormal_keratinocyte_physiol0.62953845
148MP0003448_altered_tumor_morphology0.60753319
149MP0002405_respiratory_system_inflammati0.59451648
150MP0005501_abnormal_skin_physiology0.57936834
151MP0000750_abnormal_muscle_regeneration0.57651617
152MP0005623_abnormal_meninges_morphology0.56414405
153MP0002925_abnormal_cardiovascular_devel0.56399601
154MP0003950_abnormal_plasma_membrane0.55705878
155MP0002697_abnormal_eye_size0.55512722
156MP0000432_abnormal_head_morphology0.54889465
157MP0000465_gastrointestinal_hemorrhage0.53877058
158MP0001119_abnormal_female_reproductive0.53369611
159MP0003937_abnormal_limbs/digits/tail_de0.52584070

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.08464194
2Increased cerebral lipofuscin (HP:0011813)4.49295418
3Breast hypoplasia (HP:0003187)4.43352301
4Selective tooth agenesis (HP:0001592)4.17479585
5Increased neuronal autofluorescent lipopigment (HP:0002074)4.16906209
6Abnormality of glycolipid metabolism (HP:0010969)3.86527817
7Abnormality of liposaccharide metabolism (HP:0010968)3.86527817
8Abnormality of glycosphingolipid metabolism (HP:0004343)3.86527817
9Eczematoid dermatitis (HP:0000976)3.82709012
10Ependymoma (HP:0002888)3.81580945
11Recurrent bacterial skin infections (HP:0005406)3.73580782
12Recurrent abscess formation (HP:0002722)3.70084803
13Cerebral hypomyelination (HP:0006808)3.69359023
14Abnormality of macrophages (HP:0004311)3.52848493
15Chromsome breakage (HP:0040012)3.36145452
16Patellar aplasia (HP:0006443)3.34448161
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.17587005
18Cellulitis (HP:0100658)3.16825934
19Aplasia/Hypoplasia of the patella (HP:0006498)3.08011102
20Autoimmune thrombocytopenia (HP:0001973)2.98981115
21Centrally nucleated skeletal muscle fibers (HP:0003687)2.97887728
22Reticulocytopenia (HP:0001896)2.95702382
23Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.95470213
24Mediastinal lymphadenopathy (HP:0100721)2.93580938
25Medulloblastoma (HP:0002885)2.92948736
26Loss of speech (HP:0002371)2.91282923
27Abnormality of the astrocytes (HP:0100707)2.87822840
28Astrocytoma (HP:0009592)2.87822840
29Recurrent viral infections (HP:0004429)2.87547594
30Vacuolated lymphocytes (HP:0001922)2.82476599
31Abnormality of the anterior horn cell (HP:0006802)2.82071110
32Degeneration of anterior horn cells (HP:0002398)2.82071110
33Colon cancer (HP:0003003)2.80363865
34Elevated erythrocyte sedimentation rate (HP:0003565)2.79430605
35Agnosia (HP:0010524)2.73019647
36Premature graying of hair (HP:0002216)2.69850829
37Dysostosis multiplex (HP:0000943)2.68812979
38Abnormal number of erythroid precursors (HP:0012131)2.68624601
39Petechiae (HP:0000967)2.67781259
40Obstructive lung disease (HP:0006536)2.66336892
41Chronic obstructive pulmonary disease (HP:0006510)2.66336892
42Abnormality of chromosome stability (HP:0003220)2.66010637
43Abnormality of cells of the erythroid lineage (HP:0012130)2.65856839
44Abnormality of the ileum (HP:0001549)2.64357364
45Impulsivity (HP:0100710)2.63372636
46Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.59607973
47Recurrent fungal infections (HP:0002841)2.59056123
48Entropion (HP:0000621)2.57758720
49Absent radius (HP:0003974)2.56068952
50Pustule (HP:0200039)2.55429177
51Slow saccadic eye movements (HP:0000514)2.55337864
52Hyperacusis (HP:0010780)2.54514261
53High pitched voice (HP:0001620)2.54227857
54Meckel diverticulum (HP:0002245)2.52364024
55Deviation of the thumb (HP:0009603)2.52064314
56Squamous cell carcinoma (HP:0002860)2.51805352
57Rough bone trabeculation (HP:0100670)2.51257794
58Proximal placement of thumb (HP:0009623)2.50758829
59Increased nuchal translucency (HP:0010880)2.50720375
60J-shaped sella turcica (HP:0002680)2.49227573
61Upper motor neuron abnormality (HP:0002127)2.47552439
62Glioma (HP:0009733)2.45455755
63Vertebral compression fractures (HP:0002953)2.45099547
64Rhabdomyosarcoma (HP:0002859)2.44726528
65Trismus (HP:0000211)2.43589339
66Increased serum ferritin (HP:0003281)2.43562501
67Basal cell carcinoma (HP:0002671)2.42072455
68Achilles tendon contracture (HP:0001771)2.41190483
69Ragged-red muscle fibers (HP:0003200)2.40060669
70Small intestinal stenosis (HP:0012848)2.39359614
71Duodenal stenosis (HP:0100867)2.39359614
72Recurrent skin infections (HP:0001581)2.38363178
73Meningitis (HP:0001287)2.37018563
74Colitis (HP:0002583)2.36765498
75Abnormality of the labia minora (HP:0012880)2.35533720
76Neoplasm of the oral cavity (HP:0100649)2.34575143
77Absent thumb (HP:0009777)2.34475308
78Abnormality of the preputium (HP:0100587)2.33791623
79Myelodysplasia (HP:0002863)2.32715187
80Neoplasm of the pancreas (HP:0002894)2.32612422
81Increased connective tissue (HP:0009025)2.32041525
82Aplasia involving forearm bones (HP:0009822)2.31813545
83Absent forearm bone (HP:0003953)2.31813545
84Gastrointestinal inflammation (HP:0004386)2.31077333
85Aplasia/Hypoplasia of the uvula (HP:0010293)2.30179196
86Ulnar bowing (HP:0003031)2.30114043
87Abnormal number of incisors (HP:0011064)2.30080718
88Progressive muscle weakness (HP:0003323)2.29579628
89Oral leukoplakia (HP:0002745)2.29492944
90Cholecystitis (HP:0001082)2.28182821
91Abnormal gallbladder physiology (HP:0012438)2.28182821
92Cafe-au-lait spot (HP:0000957)2.27285254
93Abnormality of the calcaneus (HP:0008364)2.27160257
94Slender long bone (HP:0003100)2.22499995
95Facial hemangioma (HP:0000329)2.22212108
96Sloping forehead (HP:0000340)2.21067299
97Chronic mucocutaneous candidiasis (HP:0002728)2.20680692
98Recurrent cutaneous fungal infections (HP:0011370)2.20680692
99Carpal bone hypoplasia (HP:0001498)2.19510387
100Poikiloderma (HP:0001029)2.16746552
101Hypoplasia of the capital femoral epiphysis (HP:0003090)2.16659088
102Atresia of the external auditory canal (HP:0000413)2.16231848
103Bone marrow hypocellularity (HP:0005528)2.15825747
104T lymphocytopenia (HP:0005403)2.15514006
105Inflammation of the large intestine (HP:0002037)2.15030986
106Panhypogammaglobulinemia (HP:0003139)2.13593168
107Progressive neurologic deterioration (HP:0002344)2.13418746
108Purpura (HP:0000979)2.12984515
109Autoimmune hemolytic anemia (HP:0001890)2.09684937
110Ankle contracture (HP:0006466)2.08072292
111Systemic lupus erythematosus (HP:0002725)2.07727010
112Recurrent gram-negative bacterial infections (HP:0005420)2.06218671
113Abnormality of the umbilical cord (HP:0010881)2.05952997
114Volvulus (HP:0002580)2.05316238
115Abnormality of polysaccharide metabolism (HP:0011012)2.04479669
116Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04479669
117Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04479669
118Prominent nose (HP:0000448)2.03466549
119Gingivitis (HP:0000230)2.02957672
120Abnormality of the Achilles tendon (HP:0005109)2.02730498
121Tongue fasciculations (HP:0001308)2.01932050
122Premature ovarian failure (HP:0008209)1.99629526
123Agammaglobulinemia (HP:0004432)1.98782592
124Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.98391164
125CNS hypomyelination (HP:0003429)1.97818839
126Diminished motivation (HP:0000745)1.97531924
127Muscle fibrillation (HP:0010546)1.97140963
128Multiple enchondromatosis (HP:0005701)1.96873695
129Upper limb amyotrophy (HP:0009129)1.96766355
130Distal upper limb amyotrophy (HP:0007149)1.96766355
131Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96509140
132Apathy (HP:0000741)1.96487401
133Neoplasm of striated muscle (HP:0009728)1.95175990
134Hypertensive crisis (HP:0100735)1.94833891
13511 pairs of ribs (HP:0000878)1.94794567
136IgM deficiency (HP:0002850)1.94670414
137Myositis (HP:0100614)1.94467968
138Lymphopenia (HP:0001888)1.93906807
139Ectopic kidney (HP:0000086)1.92879709
140Neuronal loss in central nervous system (HP:0002529)1.92861964
141Pallor (HP:0000980)1.91490997
142Ocular albinism (HP:0001107)1.90872778
143Microretrognathia (HP:0000308)1.90452089
144Increased IgE level (HP:0003212)1.90075192
145Aplasia/hypoplasia of the humerus (HP:0006507)1.89698841
146Missing ribs (HP:0000921)1.88677761
147Fatigue (HP:0012378)1.88412750
148Spinal muscular atrophy (HP:0007269)1.87902506
149Abnormal lung lobation (HP:0002101)1.87593050
150Prolonged neonatal jaundice (HP:0006579)1.86906708
151Macrocytic anemia (HP:0001972)1.86728763
152Urticaria (HP:0001025)1.86722318
153Premature rupture of membranes (HP:0001788)1.86713018
154Abnormality of the duodenum (HP:0002246)1.85429954
155Rib fusion (HP:0000902)1.84248724
156Duplicated collecting system (HP:0000081)1.84207304
157Tracheoesophageal fistula (HP:0002575)1.83420967
158Mucopolysacchariduria (HP:0008155)1.83088806
159Urinary glycosaminoglycan excretion (HP:0003541)1.83088806
160Long palpebral fissure (HP:0000637)1.82949543
161Short 4th metacarpal (HP:0010044)1.82079739
162Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.82079739
163Atrophy/Degeneration involving motor neurons (HP:0007373)1.81608528
164Abnormality of cells of the lymphoid lineage (HP:0012140)1.81485859
165Abnormality of T cells (HP:0002843)1.80870835
166Hepatosplenomegaly (HP:0001433)1.80657695
167Cellular immunodeficiency (HP:0005374)1.80629548
168Secondary amenorrhea (HP:0000869)1.79948473
169Distal lower limb amyotrophy (HP:0008944)1.79446494
170Cerebral aneurysm (HP:0004944)1.78925776
171Protrusio acetabuli (HP:0003179)1.78921310
172Thoracic kyphosis (HP:0002942)1.78007127
173Stomatitis (HP:0010280)1.77995598
174Hypokinesia (HP:0002375)1.76525474
175Hand muscle atrophy (HP:0009130)1.75873220
176Verrucae (HP:0200043)1.75426870
177Papilloma (HP:0012740)1.75426870
178Abnormal delayed hypersensitivity skin test (HP:0002963)1.74694404
179Short humerus (HP:0005792)1.73902528
180Lymphoma (HP:0002665)1.73770097
181Personality changes (HP:0000751)1.73248152
182Epistaxis (HP:0000421)1.73171060
183Megaloblastic anemia (HP:0001889)1.72367177
184Abnormality of the carotid arteries (HP:0005344)1.72290688
185Abnormality of the periventricular white matter (HP:0002518)1.72176305
186Shallow orbits (HP:0000586)1.71906068
187Abnormality of T cell number (HP:0011839)1.71678395
188Dysautonomia (HP:0002459)1.71626904
189Cutaneous melanoma (HP:0012056)1.71194902
190Abnormal trabecular bone morphology (HP:0100671)1.71058221
191Amaurosis fugax (HP:0100576)1.69794134
192Granulocytopenia (HP:0001913)1.68917059

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.71865876
2CDC73.99108563
3WEE13.32201481
4NEK22.94167694
5TESK22.69409194
6PRPF4B2.57582758
7MAP3K102.44606605
8IRAK32.43297960
9TTK2.38019242
10CDK122.32736802
11EEF2K2.31722345
12SMG12.17484132
13MAP3K32.13452571
14NEK12.12560868
15STK101.97886498
16* PLK11.89216662
17TSSK61.86551765
18TBK11.82875258
19CDK71.76461371
20ACVR1B1.74500848
21MAP2K31.74423573
22RPS6KB21.74338171
23ATR1.70853184
24TAOK21.70206133
25SCYL21.68432524
26EIF2AK11.68432192
27AURKB1.65262358
28RIPK41.63073415
29MAP3K81.62454452
30EPHA21.60346130
31BCKDK1.50064142
32CHEK21.47267320
33PASK1.46604155
34BRSK21.38321682
35PLK41.36800007
36SIK11.36603731
37TLK11.36431491
38CDK41.35993390
39SIK21.35192430
40JAK31.34640575
41DYRK31.31663240
42AURKA1.30790966
43ICK1.29961128
44CHEK11.28708935
45PAK41.28177620
46STK41.24082953
47IKBKE1.22288283
48SRPK11.21431843
49FES1.21309151
50MAP3K141.18746432
51LRRK21.17702515
52TRIB31.17561080
53VRK11.17434137
54TESK11.14379842
55IRAK41.11535462
56RPS6KA41.11196429
57PLK31.10316845
58PIM21.08856072
59BRSK11.05927864
60KIT1.04792832
61NME21.04054633
62TYK21.03318768
63TTN1.02879745
64SYK1.01079343
65MARK30.99873870
66PKN20.95766611
67PIM10.94734274
68HCK0.91810320
69MAP3K110.91677687
70* CDK20.91387905
71LIMK10.91352928
72MAP4K10.90978417
73MAP3K130.90882388
74TGFBR10.90318025
75IKBKB0.90306904
76MTOR0.89547012
77SIK30.89096309
78MKNK10.88685413
79ZAK0.87704503
80LATS20.85489774
81PAK10.85187460
82* ATM0.82926040
83MAPKAPK30.81980578
84BRD40.81131407
85EPHB10.80659830
86CLK10.78081679
87EIF2AK30.77202470
88CDK60.75955217
89LCK0.75491885
90DDR20.74453220
91CAMKK10.73241412
92ALK0.72608515
93LYN0.71688874
94TNK20.70720439
95CDK10.70633651
96ITK0.68059236
97ARAF0.67302165
98KDR0.61056741
99GRK60.60010171
100MAP3K10.59489893
101STK160.59151506
102CCNB10.58379687
103FLT30.58169927
104STK30.58107489
105ABL20.58061481
106MAP3K60.58015333
107BLK0.57659950
108FGFR40.56437089
109BMX0.55496513
110PAK20.54148935
111MELK0.54043735
112RPS6KC10.53487065
113RPS6KL10.53487065
114FGR0.52906552
115CSNK2A20.52749472
116CDC42BPA0.52715454
117RIPK10.52295813
118TXK0.52277075
119RPS6KA20.52205358
120ILK0.51455408
121CSNK2A10.49331596
122CDK90.47740925
123RPS6KA60.47595092
124HIPK20.46998354
125RPS6KA50.46491600
126TRPM70.44039058
127ERN10.42769349
128CSF1R0.42033837
129PDPK10.41137573
130MARK20.40883488
131TAOK10.40771902
132MAPK40.40465487
133CSNK1E0.38682137
134PRKD20.38608917
135PRKCI0.38518209
136MATK0.38364948
137JAK10.38332059
138CSK0.38327656
139CDK80.37880565
140YES10.37420933
141ZAP700.35409761
142BRAF0.35365231
143MAPKAPK20.34853956
144PRKDC0.34397200
145DAPK30.34253402
146UHMK10.34095496
147PDGFRA0.33311355
148BTK0.33282271
149AKT20.33174155
150MAPK110.32574940

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.17680058
2Mismatch repair_Homo sapiens_hsa034304.55246729
3Base excision repair_Homo sapiens_hsa034103.54267399
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.22569553
5Spliceosome_Homo sapiens_hsa030403.13572756
6* Cell cycle_Homo sapiens_hsa041103.01996988
7RNA transport_Homo sapiens_hsa030132.96408065
8Other glycan degradation_Homo sapiens_hsa005112.89961166
9Nucleotide excision repair_Homo sapiens_hsa034202.82290630
10Homologous recombination_Homo sapiens_hsa034402.79324758
11One carbon pool by folate_Homo sapiens_hsa006702.70224781
12Proteasome_Homo sapiens_hsa030502.62738496
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.56361563
14Allograft rejection_Homo sapiens_hsa053302.30566066
15Ribosome_Homo sapiens_hsa030102.26507016
16RNA polymerase_Homo sapiens_hsa030202.25108965
17Fanconi anemia pathway_Homo sapiens_hsa034602.22074287
18Non-homologous end-joining_Homo sapiens_hsa034502.16818927
19Graft-versus-host disease_Homo sapiens_hsa053322.15093655
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.05417596
21Autoimmune thyroid disease_Homo sapiens_hsa053202.05354527
22Leishmaniasis_Homo sapiens_hsa051401.96518355
23Pyrimidine metabolism_Homo sapiens_hsa002401.88869083
24Osteoclast differentiation_Homo sapiens_hsa043801.88376740
25Lysosome_Homo sapiens_hsa041421.79179663
26p53 signaling pathway_Homo sapiens_hsa041151.76121580
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.69834027
28Systemic lupus erythematosus_Homo sapiens_hsa053221.66966278
29Asthma_Homo sapiens_hsa053101.66622857
30mRNA surveillance pathway_Homo sapiens_hsa030151.62699974
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.61438658
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.60789874
33Staphylococcus aureus infection_Homo sapiens_hsa051501.56913151
34RNA degradation_Homo sapiens_hsa030181.52929374
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.47376906
36Tuberculosis_Homo sapiens_hsa051521.40837059
37T cell receptor signaling pathway_Homo sapiens_hsa046601.37875251
38Basal transcription factors_Homo sapiens_hsa030221.36898266
39Type I diabetes mellitus_Homo sapiens_hsa049401.33853865
40* Viral carcinogenesis_Homo sapiens_hsa052031.32613660
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27183751
42Influenza A_Homo sapiens_hsa051641.25560414
43Toxoplasmosis_Homo sapiens_hsa051451.24289945
44Epstein-Barr virus infection_Homo sapiens_hsa051691.18904851
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17971836
46Biosynthesis of amino acids_Homo sapiens_hsa012301.16586189
47Rheumatoid arthritis_Homo sapiens_hsa053231.09533224
48Phagosome_Homo sapiens_hsa041451.07834088
49Salmonella infection_Homo sapiens_hsa051321.07517567
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05140468
51Oocyte meiosis_Homo sapiens_hsa041141.00142229
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98183295
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97525526
54TNF signaling pathway_Homo sapiens_hsa046680.97347171
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96654842
56Selenocompound metabolism_Homo sapiens_hsa004500.96446918
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95637309
58Pentose phosphate pathway_Homo sapiens_hsa000300.95335542
59Folate biosynthesis_Homo sapiens_hsa007900.94921037
60Malaria_Homo sapiens_hsa051440.93243811
61VEGF signaling pathway_Homo sapiens_hsa043700.91100137
62Small cell lung cancer_Homo sapiens_hsa052220.90622554
63HTLV-I infection_Homo sapiens_hsa051660.90057683
64Antigen processing and presentation_Homo sapiens_hsa046120.86572260
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85851970
66Purine metabolism_Homo sapiens_hsa002300.85496280
67MicroRNAs in cancer_Homo sapiens_hsa052060.82496437
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82489267
69Primary immunodeficiency_Homo sapiens_hsa053400.81212934
70Vitamin B6 metabolism_Homo sapiens_hsa007500.81104730
71* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80487403
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.80199612
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75372438
74Endocytosis_Homo sapiens_hsa041440.74490200
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.71556356
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71170817
77Shigellosis_Homo sapiens_hsa051310.70967140
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.70691405
79Herpes simplex infection_Homo sapiens_hsa051680.68775628
80Notch signaling pathway_Homo sapiens_hsa043300.67393171
81Hepatitis C_Homo sapiens_hsa051600.67076200
82Colorectal cancer_Homo sapiens_hsa052100.66520086
83Chronic myeloid leukemia_Homo sapiens_hsa052200.66336217
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.66136745
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65563147
86Pertussis_Homo sapiens_hsa051330.65367459
87Prion diseases_Homo sapiens_hsa050200.65014990
88Hippo signaling pathway_Homo sapiens_hsa043900.64640160
89mTOR signaling pathway_Homo sapiens_hsa041500.62726221
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62080803
91Apoptosis_Homo sapiens_hsa042100.61920405
92Lysine degradation_Homo sapiens_hsa003100.59674341
93Alcoholism_Homo sapiens_hsa050340.58016102
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57576620
95Fructose and mannose metabolism_Homo sapiens_hsa000510.55788054
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55724564
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55016045
98Carbon metabolism_Homo sapiens_hsa012000.54317371
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.53689068
100Legionellosis_Homo sapiens_hsa051340.53688110
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52480282
102Thyroid cancer_Homo sapiens_hsa052160.51580519
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50965891
104Chemokine signaling pathway_Homo sapiens_hsa040620.49501733
105Basal cell carcinoma_Homo sapiens_hsa052170.48707351
106Bladder cancer_Homo sapiens_hsa052190.48171877
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48053917
108Vibrio cholerae infection_Homo sapiens_hsa051100.47878012
109Sulfur relay system_Homo sapiens_hsa041220.47442668
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47192466
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.44367549
112Platelet activation_Homo sapiens_hsa046110.43765584
113Glutathione metabolism_Homo sapiens_hsa004800.43406935
114Hepatitis B_Homo sapiens_hsa051610.42971462
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.42741205
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42689563
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41866752
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40781009
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40778940
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40742506
121Acute myeloid leukemia_Homo sapiens_hsa052210.40364307
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40193553
123Hedgehog signaling pathway_Homo sapiens_hsa043400.40101401
124Adherens junction_Homo sapiens_hsa045200.37779927
125TGF-beta signaling pathway_Homo sapiens_hsa043500.37587098
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.36788681
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34969941
128N-Glycan biosynthesis_Homo sapiens_hsa005100.34695813
129Non-small cell lung cancer_Homo sapiens_hsa052230.33003006
130Pancreatic cancer_Homo sapiens_hsa052120.31766889
131Pathways in cancer_Homo sapiens_hsa052000.31262299
132Arginine and proline metabolism_Homo sapiens_hsa003300.29211200
133Measles_Homo sapiens_hsa051620.28286271
134Viral myocarditis_Homo sapiens_hsa054160.27889672
135Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26665038
136Proteoglycans in cancer_Homo sapiens_hsa052050.26123229
137Tight junction_Homo sapiens_hsa045300.25976287
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25431907
139Prostate cancer_Homo sapiens_hsa052150.25286115
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.23710654
141PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23687526
142HIF-1 signaling pathway_Homo sapiens_hsa040660.23413473
143Endometrial cancer_Homo sapiens_hsa052130.23143811
144Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21388916
145AMPK signaling pathway_Homo sapiens_hsa041520.21359443
146Galactose metabolism_Homo sapiens_hsa000520.20924608
147NF-kappa B signaling pathway_Homo sapiens_hsa040640.19213230
148B cell receptor signaling pathway_Homo sapiens_hsa046620.19179306
149Hematopoietic cell lineage_Homo sapiens_hsa046400.18613621

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