MADCAM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of antigen processing and presentation (GO:0002579)9.58549744
2cellular protein complex localization (GO:0034629)8.91639468
3positive regulation of Cdc42 GTPase activity (GO:0043089)8.70746609
4positive regulation of glycoprotein biosynthetic process (GO:0010560)8.10571455
5regulation of antigen processing and presentation (GO:0002577)7.93369964
6response to nitric oxide (GO:0071731)7.55168066
7positive regulation of granulocyte chemotaxis (GO:0071624)7.23604194
8positive regulation of glycoprotein metabolic process (GO:1903020)7.23166810
9positive regulation of T-helper 1 type immune response (GO:0002827)7.07936850
10synapsis (GO:0007129)6.91789430
11imidazole-containing compound metabolic process (GO:0052803)6.85495795
12positive regulation of T-helper cell differentiation (GO:0045624)6.79592843
13positive regulation of neutrophil chemotaxis (GO:0090023)6.75056027
14positive regulation of neutrophil migration (GO:1902624)6.75056027
15regulation of guanylate cyclase activity (GO:0031282)6.42046336
16response to prostaglandin E (GO:0034695)6.39012861
17positive regulation of guanylate cyclase activity (GO:0031284)6.27208628
18protein complex localization (GO:0031503)6.07853924
19single strand break repair (GO:0000012)6.00032288
20DNA strand renaturation (GO:0000733)5.84086295
21regulation of cellular extravasation (GO:0002691)5.62434475
22synaptic vesicle maturation (GO:0016188)5.57099483
23striated muscle atrophy (GO:0014891)5.54569550
24protein kinase C signaling (GO:0070528)5.35318353
25skeletal muscle tissue regeneration (GO:0043403)5.34244680
26regulation of helicase activity (GO:0051095)5.25816019
27muscle atrophy (GO:0014889)5.22864395
28positive regulation of interleukin-1 beta secretion (GO:0050718)5.19671194
29ovulation from ovarian follicle (GO:0001542)5.11351786
30positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)5.10582087
31response to gravity (GO:0009629)5.05227778
32dendritic cell chemotaxis (GO:0002407)4.97251269
33regulation of T-helper 1 type immune response (GO:0002825)4.96767863
34skeletal muscle adaptation (GO:0043501)4.95010488
35positive regulation of pseudopodium assembly (GO:0031274)4.94473351
36regulation of neutrophil migration (GO:1902622)4.83863626
37regulation of neutrophil chemotaxis (GO:0090022)4.83863626
38positive regulation of interleukin-1 secretion (GO:0050716)4.82765143
39negative regulation of muscle hypertrophy (GO:0014741)4.79112940
40response to prostaglandin (GO:0034694)4.70682332
41regulation of T-helper cell differentiation (GO:0045622)4.66386255
42receptor guanylyl cyclase signaling pathway (GO:0007168)4.65990320
43positive regulation of NF-kappaB import into nucleus (GO:0042346)4.54866739
44collecting duct development (GO:0072044)4.53340428
45regulation of Cdc42 GTPase activity (GO:0043088)4.53259841
46regulation of interleukin-1 beta secretion (GO:0050706)4.53013274
47regulation of bile acid biosynthetic process (GO:0070857)4.50736203
48regulation of pseudopodium assembly (GO:0031272)4.40599657
49dendritic cell differentiation (GO:0097028)4.35839170
50positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.30946371
51aorta morphogenesis (GO:0035909)4.29631006
52positive regulation of interleukin-1 beta production (GO:0032731)4.28521938
53synaptic vesicle endocytosis (GO:0048488)4.26804868
54mature B cell differentiation involved in immune response (GO:0002313)4.25231545
55cytokine secretion (GO:0050663)4.18133247
56oogenesis (GO:0048477)4.15181651
57regulation of granulocyte chemotaxis (GO:0071622)4.13182385
58trivalent inorganic anion homeostasis (GO:0072506)4.12977676
59phosphate ion homeostasis (GO:0055062)4.12977676
60establishment of mitochondrion localization (GO:0051654)4.12462279
61regulation of interleukin-1 secretion (GO:0050704)4.00832882
62positive regulation of insulin receptor signaling pathway (GO:0046628)3.99095697
63negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.98564923
64positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)3.98215186
65positive regulation of urine volume (GO:0035810)3.96765378
66negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.93354663
67cellular anion homeostasis (GO:0030002)3.92249433
68regulation of cGMP biosynthetic process (GO:0030826)3.91962757
69positive regulation of lipid kinase activity (GO:0090218)3.87745265
70negative regulation of androgen receptor signaling pathway (GO:0060766)3.87521867
71response to muscle activity (GO:0014850)3.80962361
72detection of bacterium (GO:0016045)3.77586141
73vitamin catabolic process (GO:0009111)3.74060601
74fat-soluble vitamin catabolic process (GO:0042363)3.74060601
75endothelial tube morphogenesis (GO:0061154)3.73790483
76morphogenesis of an endothelium (GO:0003159)3.73790483
77positive regulation of interleukin-1 production (GO:0032732)3.72715165
78negative regulation of skeletal muscle tissue development (GO:0048642)3.70687427
79negative regulation of fatty acid biosynthetic process (GO:0045717)3.69469071
80positive regulation of cGMP biosynthetic process (GO:0030828)3.69001736
81positive regulation of interleukin-12 production (GO:0032735)3.65961812
82long term synaptic depression (GO:0060292)3.60412203
83regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.58927534
84fatty acid homeostasis (GO:0055089)3.58452563
85regulation of histone H3-K9 methylation (GO:0051570)3.55709732
86pyrimidine dimer repair (GO:0006290)3.52863699
87NIK/NF-kappaB signaling (GO:0038061)3.52519566
88dendritic cell migration (GO:0036336)3.49430836
89protein targeting to vacuole (GO:0006623)3.47790758
90protein targeting to lysosome (GO:0006622)3.47790758
91establishment of protein localization to vacuole (GO:0072666)3.47790758
92protein insertion into membrane (GO:0051205)3.47671809
93regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.45807743
94renal absorption (GO:0070293)3.45370322
95blood vessel maturation (GO:0001955)3.44295043
96protein localization to synapse (GO:0035418)3.44274168
97positive regulation of synapse maturation (GO:0090129)3.43107501
98detection of light stimulus involved in visual perception (GO:0050908)3.42398942
99detection of light stimulus involved in sensory perception (GO:0050962)3.42398942
100substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.40863553
101substrate-independent telencephalic tangential migration (GO:0021826)3.40863553
102positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.40350423
103ventricular trabecula myocardium morphogenesis (GO:0003222)3.39166554
104sympathetic nervous system development (GO:0048485)3.35480349
105peptidyl-tyrosine autophosphorylation (GO:0038083)3.32076231
106endothelial cell morphogenesis (GO:0001886)3.30879117
107regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.29197442
108detection of other organism (GO:0098543)3.29088415
109lateral ventricle development (GO:0021670)3.26492171
110negative regulation of cell aging (GO:0090344)3.24879227
111positive regulation of cholesterol efflux (GO:0010875)3.24535583
112negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.23567472
113regulation of MHC class II biosynthetic process (GO:0045346)3.21110890
114establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.20409178
115mitochondrion transport along microtubule (GO:0047497)3.20409178
116positive regulation of DNA-templated transcription, initiation (GO:2000144)3.19394051
117positive regulation of transcription factor import into nucleus (GO:0042993)3.19341342
118synaptic vesicle exocytosis (GO:0016079)3.18845158
119regulation of cGMP metabolic process (GO:0030823)3.18271345
120phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.17381404
121positive regulation of cGMP metabolic process (GO:0030825)3.16444799
122epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.15641836
123regulation of cellular senescence (GO:2000772)3.14785864
124positive regulation of release of cytochrome c from mitochondria (GO:0090200)3.13857526
125regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.13038941
126fat-soluble vitamin biosynthetic process (GO:0042362)3.12394263
127protein retention in ER lumen (GO:0006621)3.11422594
128trabecula morphogenesis (GO:0061383)3.11368022
129neuronal action potential (GO:0019228)3.09697619
130antigen processing and presentation of endogenous antigen (GO:0019883)3.08944491
131cellular potassium ion homeostasis (GO:0030007)3.03253664
132heart trabecula morphogenesis (GO:0061384)2.99171359
133potassium ion homeostasis (GO:0055075)2.98245658
134positive regulation of alpha-beta T cell differentiation (GO:0046638)2.97315622
135regulation of glycoprotein biosynthetic process (GO:0010559)2.95993852
136cellular response to dexamethasone stimulus (GO:0071549)2.95826857
137sulfur amino acid catabolic process (GO:0000098)2.95379146
138skin development (GO:0043588)2.92462914
139neuron cell-cell adhesion (GO:0007158)2.88839690
140alkaloid metabolic process (GO:0009820)2.88062158
141regulation of synapse maturation (GO:0090128)2.86870133
142mature B cell differentiation (GO:0002335)2.86598405
143fucose catabolic process (GO:0019317)2.86364252
144L-fucose metabolic process (GO:0042354)2.86364252
145L-fucose catabolic process (GO:0042355)2.86364252
146positive regulation of respiratory burst (GO:0060267)2.84460272
147postsynaptic membrane organization (GO:0001941)2.80472084
148regulation of systemic arterial blood pressure by hormone (GO:0001990)2.79866065
149regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.79866065
150endocrine process (GO:0050886)2.79866065
151regulation of female receptivity (GO:0045924)2.79696526
152regulation of glycogen (starch) synthase activity (GO:2000465)2.75123148
153diacylglycerol metabolic process (GO:0046339)2.74701840
154negative regulation of telomere maintenance (GO:0032205)2.72418735
155membrane depolarization during action potential (GO:0086010)2.70476070
156layer formation in cerebral cortex (GO:0021819)2.69683097
157regulation of respiratory burst (GO:0060263)2.69305488
158barbed-end actin filament capping (GO:0051016)2.67563039
159positive regulation of actin cytoskeleton reorganization (GO:2000251)2.66953496
160lung morphogenesis (GO:0060425)2.64525730
161growth hormone secretion (GO:0030252)2.63377554
162arginine metabolic process (GO:0006525)2.63336289
163regulation of systemic arterial blood pressure (GO:0003073)2.62281681
164membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.61155143
165otic vesicle formation (GO:0030916)2.59033060
166neuronal stem cell maintenance (GO:0097150)2.58496853
167transmission of nerve impulse (GO:0019226)2.58009364
168cell-cell junction maintenance (GO:0045217)2.54087448
169synaptic transmission, dopaminergic (GO:0001963)2.52375115
170chromatin silencing (GO:0006342)2.51965450
171lymphangiogenesis (GO:0001946)2.49587579
172maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.46645956
173low-density lipoprotein particle remodeling (GO:0034374)2.46142086
174vitamin biosynthetic process (GO:0009110)2.44315156
175regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.44240757
176arginine catabolic process (GO:0006527)2.43892228
177positive regulation of potassium ion transmembrane transport (GO:1901381)2.43035317
178angiotensin maturation (GO:0002003)2.42743394
179positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.42140459
180regulation of synapse structural plasticity (GO:0051823)2.41321602
181glycerophospholipid catabolic process (GO:0046475)2.39380670
182GDP-mannose metabolic process (GO:0019673)2.38503810
183calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.37456930
184primary amino compound metabolic process (GO:1901160)2.36887059
185positive regulation of male gonad development (GO:2000020)2.36291882
186negative regulation of glycoprotein biosynthetic process (GO:0010561)2.35472060
187regulation of protein heterodimerization activity (GO:0043497)2.33525110
188head development (GO:0060322)2.32788846
189negative regulation of mast cell activation (GO:0033004)2.31906729
190adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.30387110
191autophagic vacuole assembly (GO:0000045)2.29877238
192regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.29700632
193locomotory exploration behavior (GO:0035641)2.29183452
194positive regulation of mitochondrial fission (GO:0090141)2.28600510
195potassium ion import (GO:0010107)2.28569980
196regulation of dendritic cell antigen processing and presentation (GO:0002604)14.0645201
197regulation of T-helper 1 cell differentiation (GO:0045625)10.5679508

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse8.04453099
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human5.58003149
3TP63_17297297_ChIP-ChIP_HaCaT_Human5.35325803
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.36378013
5NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.66938521
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.33668306
7E2F7_22180533_ChIP-Seq_HELA_Human3.28302375
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.26607594
9* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.95181014
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.90333889
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.68790594
12VDR_22108803_ChIP-Seq_LS180_Human2.56610399
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.52874881
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.50443053
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.45392918
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.44421076
17LXR_22292898_ChIP-Seq_THP-1_Human2.41074736
18CLOCK_20551151_ChIP-Seq_293T_Human2.28896217
19BCL6_27268052_Chip-Seq_Bcells_Human2.27307102
20* P68_20966046_ChIP-Seq_HELA_Human2.23126780
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.22410322
22TCF3_18692474_ChIP-Seq_MEFs_Mouse2.15107948
23ELF1_20517297_ChIP-Seq_JURKAT_Human2.09479821
24TET1_21451524_ChIP-Seq_MESCs_Mouse2.04532347
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.02757592
26CTCF_27219007_Chip-Seq_Bcells_Human2.01894049
27DNAJC2_21179169_ChIP-ChIP_NT2_Human1.98256457
28PHF8_20622854_ChIP-Seq_HELA_Human1.92874863
29NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.86251349
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.84950553
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83809370
32SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.81781871
33VDR_21846776_ChIP-Seq_THP-1_Human1.77401673
34GATA1_19941826_ChIP-Seq_K562_Human1.75936971
35* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75529574
36DROSHA_22980978_ChIP-Seq_HELA_Human1.74907540
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.73774292
38KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.70981719
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70938039
40SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.69476807
41TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.68361447
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.67885251
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.67706062
44GATA1_26923725_Chip-Seq_HPCs_Mouse1.66028936
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64845129
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64663045
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.61974069
48* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61949804
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.61732514
50REST_21632747_ChIP-Seq_MESCs_Mouse1.61669013
51CTCF_20526341_ChIP-Seq_ESCs_Human1.61316533
52STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.60592793
53TCF3_18692474_ChIP-Seq_MESCs_Mouse1.60128137
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.59796619
55ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59395777
56SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.57770316
57NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.57550338
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.57378631
59PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.56725902
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.54509121
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.53261263
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.51803466
63NANOG_18692474_ChIP-Seq_MEFs_Mouse1.51579011
64SOX2_20726797_ChIP-Seq_SW620_Human1.51016814
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.50922128
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50405633
67SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.49732886
68EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.48660042
69E2F1_20622854_ChIP-Seq_HELA_Human1.46696238
70TCF4_18268006_ChIP-ChIP_LS174T_Human1.46685782
71SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46000960
72SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44842464
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.42150473
74SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.41487107
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41464791
76* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40469511
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39883154
78SA1_27219007_Chip-Seq_ERYTHROID_Human1.39412792
79SMC4_20622854_ChIP-Seq_HELA_Human1.38212914
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.36360779
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.35117308
82* KDM2B_26808549_Chip-Seq_DND41_Human1.33673218
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33049245
84YY1_22570637_ChIP-Seq_MALME-3M_Human1.32843003
85RAC3_21632823_ChIP-Seq_H3396_Human1.32525418
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32353261
87OCT4_19829295_ChIP-Seq_ESCs_Human1.32050789
88SA1_27219007_Chip-Seq_Bcells_Human1.31996756
89TP53_18474530_ChIP-ChIP_U2OS_Human1.31792189
90JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31679187
91GATA2_21666600_ChIP-Seq_HMVEC_Human1.29077962
92REST_18959480_ChIP-ChIP_MESCs_Mouse1.29002574
93POU5F1_16518401_ChIP-PET_MESCs_Mouse1.28558394
94BCOR_27268052_Chip-Seq_Bcells_Human1.27680789
95* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.27362901
96ELK3_25401928_ChIP-Seq_HUVEC_Human1.27293523
97RNF2_18974828_ChIP-Seq_MESCs_Mouse1.26436459
98EZH2_18974828_ChIP-Seq_MESCs_Mouse1.26436459
99KLF4_19829295_ChIP-Seq_ESCs_Human1.25007467
100ZNF274_21170338_ChIP-Seq_K562_Hela1.24647578
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23510282
102TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.23298463
103RAD21_21589869_ChIP-Seq_MESCs_Mouse1.22822622
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22498790
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22498790
106KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22498790
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22405234
108SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22055455
109GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21437698
110EGR1_19032775_ChIP-ChIP_M12_Human1.19361332
111SCL_19346495_ChIP-Seq_HPC-7_Human1.19265552
112MYC_19079543_ChIP-ChIP_MESCs_Mouse1.19145727
113MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18595219
114STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17552157
115TP53_22127205_ChIP-Seq_IMR90_Human1.16795627
116NANOG_18692474_ChIP-Seq_MESCs_Mouse1.16733501
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16637192
118ELK4_26923725_Chip-Seq_MESODERM_Mouse1.16306011
119CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15274050
120JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.14767629
121RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.13508441
122RUNX1_27514584_Chip-Seq_MCF-7_Human1.12771430
123EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12599259
124KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12214131
125SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11628315
126RARA_24833708_ChIP-Seq_LIVER_Mouse1.11266723
127RARB_27405468_Chip-Seq_BRAIN_Mouse1.10905569
128TAF2_19829295_ChIP-Seq_ESCs_Human1.10563746
129SOX2_18692474_ChIP-Seq_MEFs_Mouse1.10403434
130SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09927070
131EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09544628
132SPI1_20517297_ChIP-Seq_HL60_Human1.08919759
133AR_21909140_ChIP-Seq_LNCAP_Human1.08578414
134LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08434150
135CREB1_26743006_Chip-Seq_LNCaP_Human1.07434566
136NOTCH1_21737748_ChIP-Seq_TLL_Human1.06701471
137CIITA_25753668_ChIP-Seq_RAJI_Human1.06572021
138GATA2_19941826_ChIP-Seq_K562_Human1.06369021
139ERA_21632823_ChIP-Seq_H3396_Human1.06347082
140* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03640810
141IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03516481
142SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02854231
143SALL1_21062744_ChIP-ChIP_HESCs_Human1.02197736
144GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.02167120
145CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01278361
146RUNX1_26923725_Chip-Seq_HPCs_Mouse1.01143225
147FOXO3_23340844_ChIP-Seq_DLD1_Human1.00968013
148FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00878977
149TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.00451281
150FOXM1_23109430_ChIP-Seq_U2OS_Human1.00449311
151MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00378644
152OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00179526
153* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00002610
154TET1_21490601_ChIP-Seq_MESCs_Mouse0.99834205
155CDX2_22108803_ChIP-Seq_LS180_Human0.99518061
156CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99319710
157OCT4_20526341_ChIP-Seq_ESCs_Human0.98727391
158P53_21459846_ChIP-Seq_SAOS-2_Human0.98495663
159NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97634432
160SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96849431
161HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94935106
162TBX20_22080862_ChIP-Seq_HEART_Mouse0.93686719
163TBX20_22328084_ChIP-Seq_HEART_Mouse0.93686719
164RING1B_27294783_Chip-Seq_NPCs_Mouse0.92821612
165ISL1_27105846_Chip-Seq_CPCs_Mouse0.92502723
166STAT3_18555785_ChIP-Seq_MESCs_Mouse0.92173376
167BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92030385
168POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90317206
169THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87882083
170* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85380329
171SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85224167
172EED_16625203_ChIP-ChIP_MESCs_Mouse0.85077127
173PIAS1_25552417_ChIP-Seq_VCAP_Human0.84166221
174P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.84135207
175KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83427244
176SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83187297
177IRF8_22096565_ChIP-ChIP_GC-B_Human0.82904464
178ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81863875
179ESR2_21235772_ChIP-Seq_MCF-7_Human0.80762152
180GATA3_21878914_ChIP-Seq_MCF-7_Human0.79070135
181ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78369975
182KDM2B_26808549_Chip-Seq_K562_Human0.77079619
183EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.76880771
184P300_27268052_Chip-Seq_Bcells_Human0.76159935
185ATF3_27146783_Chip-Seq_COLON_Human0.76133659
186VDR_24787735_ChIP-Seq_THP-1_Human0.76074831

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat6.19262295
2MP0000685_abnormal_immune_system5.83130129
3MP0002653_abnormal_ependyma_morphology5.24208092
4MP0002138_abnormal_hepatobiliary_system4.58988927
5MP0008057_abnormal_DNA_replication4.57542552
6MP0005647_abnormal_sex_gland4.53082891
7MP0002876_abnormal_thyroid_physiology4.32450470
8MP0002160_abnormal_reproductive_system3.83960075
9MP0005360_urolithiasis3.63808686
10MP0006054_spinal_hemorrhage3.55970153
11MP0000678_abnormal_parathyroid_gland3.54718218
12MP0003172_abnormal_lysosome_physiology3.51891328
13MP0001348_abnormal_lacrimal_gland3.48086439
14MP0001873_stomach_inflammation3.09923632
15MP0004510_myositis2.96638215
16MP0001346_abnormal_lacrimal_gland2.65582822
17MP0005503_abnormal_tendon_morphology2.58581287
18MP0004270_analgesia2.40929531
19MP0009278_abnormal_bone_marrow2.36388326
20MP0003303_peritoneal_inflammation2.33716374
21MP0004859_abnormal_synaptic_plasticity2.33581535
22MP0009333_abnormal_splenocyte_physiolog2.28933785
23MP0004858_abnormal_nervous_system2.22420325
24MP0003828_pulmonary_edema2.21122639
25MP0002089_abnormal_postnatal_growth/wei2.20327758
26MP0001188_hyperpigmentation2.09852547
27MP0002733_abnormal_thermal_nociception2.08811045
28MP0008004_abnormal_stomach_pH2.05524834
29MP0006276_abnormal_autonomic_nervous2.01773656
30MP0000751_myopathy1.96272551
31MP0004272_abnormal_basement_membrane1.92765656
32MP0005389_reproductive_system_phenotype1.89317423
33MP0003300_gastrointestinal_ulcer1.82556585
34MP0005310_abnormal_salivary_gland1.81215111
35MP0001970_abnormal_pain_threshold1.75781289
36MP0002735_abnormal_chemical_nociception1.69674773
37MP0009379_abnormal_foot_pigmentation1.69646612
38MP0003787_abnormal_imprinting1.67709217
39MP0005409_darkened_coat_color1.67272847
40MP0001881_abnormal_mammary_gland1.66586528
41MP0001664_abnormal_digestion1.66433693
42MP0002909_abnormal_adrenal_gland1.65849219
43MP0001968_abnormal_touch/_nociception1.64834905
44MP0002108_abnormal_muscle_morphology1.61225126
45MP0006292_abnormal_olfactory_placode1.60388251
46MP0002822_catalepsy1.60082922
47MP0001485_abnormal_pinna_reflex1.57404780
48MP0001835_abnormal_antigen_presentation1.53927203
49MP0003635_abnormal_synaptic_transmissio1.52162776
50MP0002736_abnormal_nociception_after1.51790242
51MP0003329_amyloid_beta_deposits1.48610390
52MP0010352_gastrointestinal_tract_polyps1.45790297
53MP0009840_abnormal_foam_cell1.42241799
54MP0000049_abnormal_middle_ear1.38672948
55MP0003122_maternal_imprinting1.35999256
56MP0005645_abnormal_hypothalamus_physiol1.35654965
57MP0005058_abnormal_lysosome_morphology1.33609433
58MP0002064_seizures1.32355460
59MP0001879_abnormal_lymphatic_vessel1.29936185
60MP0002063_abnormal_learning/memory/cond1.28257746
61MP0003638_abnormal_response/metabolism_1.28176991
62MP0001486_abnormal_startle_reflex1.28116215
63MP0003879_abnormal_hair_cell1.24882200
64MP0002249_abnormal_larynx_morphology1.22915315
65MP0005365_abnormal_bile_salt1.22159883
66MP0000470_abnormal_stomach_morphology1.21781258
67MP0006082_CNS_inflammation1.21330634
68MP0005076_abnormal_cell_differentiation1.20849292
69MP0001502_abnormal_circadian_rhythm1.19838344
70MP0009046_muscle_twitch1.17883438
71MP0000681_abnormal_thyroid_gland1.15893518
72MP0010368_abnormal_lymphatic_system1.15723859
73MP0002127_abnormal_cardiovascular_syste1.15203911
74MP0001986_abnormal_taste_sensitivity1.14908977
75MP0000383_abnormal_hair_follicle1.12703005
76MP0003453_abnormal_keratinocyte_physiol1.12065116
77MP0000467_abnormal_esophagus_morphology1.11836083
78MP0003724_increased_susceptibility_to1.11361494
79MP0003880_abnormal_central_pattern1.08577717
80MP0002572_abnormal_emotion/affect_behav1.08089675
81MP0001545_abnormal_hematopoietic_system1.06465965
82MP0005397_hematopoietic_system_phenotyp1.06465965
83MP0009745_abnormal_behavioral_response1.06229868
84MP0004782_abnormal_surfactant_physiolog1.06155644
85MP0001501_abnormal_sleep_pattern1.05014580
86MP0003566_abnormal_cell_adhesion1.04224351
87MP0003633_abnormal_nervous_system1.04067804
88MP0004885_abnormal_endolymph1.03897730
89MP0003045_fibrosis1.03518845
90MP0004019_abnormal_vitamin_homeostasis1.02500902
91MP0005670_abnormal_white_adipose1.02259483
92MP0000013_abnormal_adipose_tissue1.00442448
93MP0005671_abnormal_response_to1.00201560
94MP0005275_abnormal_skin_tensile0.99844475
95MP0004264_abnormal_extraembryonic_tissu0.99821805
96MP0002928_abnormal_bile_duct0.97988220
97MP0010678_abnormal_skin_adnexa0.97888297
98MP0005381_digestive/alimentary_phenotyp0.97435993
99MP0003890_abnormal_embryonic-extraembry0.97038332
100MP0005448_abnormal_energy_balance0.96511335
101MP0000604_amyloidosis0.95041358
102MP0000767_abnormal_smooth_muscle0.95001831
103MP0008775_abnormal_heart_ventricle0.94989564
104MP0002796_impaired_skin_barrier0.93572235
105MP0003436_decreased_susceptibility_to0.93513131
106MP0002971_abnormal_brown_adipose0.92666858
107MP0003567_abnormal_fetal_cardiomyocyte0.91660070
108MP0002405_respiratory_system_inflammati0.88887265
109MP0000003_abnormal_adipose_tissue0.88382265
110MP0000465_gastrointestinal_hemorrhage0.87829859
111MP0002148_abnormal_hypersensitivity_rea0.86976917
112MP0010234_abnormal_vibrissa_follicle0.86887750
113MP0000230_abnormal_systemic_arterial0.85004132
114MP0005551_abnormal_eye_electrophysiolog0.82961012
115MP0000026_abnormal_inner_ear0.81718212
116MP0003866_abnormal_defecation0.80568756
117MP0001853_heart_inflammation0.80011087
118MP0002272_abnormal_nervous_system0.79535977
119MP0001851_eye_inflammation0.78533900
120MP0009764_decreased_sensitivity_to0.77289520
121MP0009384_cardiac_valve_regurgitation0.76575816
122MP0000490_abnormal_crypts_of0.76061918
123MP0001963_abnormal_hearing_physiology0.75575096
124MP0006138_congestive_heart_failure0.74984031
125MP0004924_abnormal_behavior0.74464166
126MP0005386_behavior/neurological_phenoty0.74464166
127MP0005167_abnormal_blood-brain_barrier0.73765884
128MP0003693_abnormal_embryo_hatching0.73066802
129MP0005220_abnormal_exocrine_pancreas0.72504164
130MP0002295_abnormal_pulmonary_circulatio0.72442517
131MP0001529_abnormal_vocalization0.72354713
132MP0005334_abnormal_fat_pad0.72291923
133MP0003183_abnormal_peptide_metabolism0.72056734
134MP0003959_abnormal_lean_body0.71483374
135MP0000778_abnormal_nervous_system0.70355086
136MP0001764_abnormal_homeostasis0.70309137
137MP0002139_abnormal_hepatobiliary_system0.69069832
138MP0001800_abnormal_humoral_immune0.67162675
139MP0005387_immune_system_phenotype0.66587676
140MP0001790_abnormal_immune_system0.66587676
141MP0001533_abnormal_skeleton_physiology0.65675395
142MP0003448_altered_tumor_morphology0.65337880
143MP0001666_abnormal_nutrient_absorption0.64876013
144MP0000613_abnormal_salivary_gland0.64654489
145MP0002877_abnormal_melanocyte_morpholog0.63216038
146MP0003121_genomic_imprinting0.62876314
147MP0002067_abnormal_sensory_capabilities0.62723750
148MP0000631_abnormal_neuroendocrine_gland0.61993917
149MP0000566_synostosis0.61942703
150MP0002396_abnormal_hematopoietic_system0.61932688
151MP0003938_abnormal_ear_development0.61894142
152MP0005164_abnormal_response_to0.61049641
153MP0003119_abnormal_digestive_system0.58513959
154MP0005501_abnormal_skin_physiology0.57777561
155MP0009115_abnormal_fat_cell0.57371944
156MP0001663_abnormal_digestive_system0.56475223
157MP0004957_abnormal_blastocyst_morpholog0.55661156
158MP0000343_altered_response_to0.54195637
159MP0002896_abnormal_bone_mineralization0.53157427
160MP0002970_abnormal_white_adipose0.52887529
161MP0005388_respiratory_system_phenotype0.52669402
162MP0002133_abnormal_respiratory_system0.52669402
163MP0001845_abnormal_inflammatory_respons0.52456224
164MP0002734_abnormal_mechanical_nocicepti0.52033175
165MP0002277_abnormal_respiratory_mucosa0.51298507
166MP0003705_abnormal_hypodermis_morpholog0.50761752
167MP0005025_abnormal_response_to0.50749459
168MP0003868_abnormal_feces_composition0.48366336
169MP0002925_abnormal_cardiovascular_devel0.47066693
170MP0010155_abnormal_intestine_physiology0.45600340
171MP0004185_abnormal_adipocyte_glucose0.45361468
172MP0000627_abnormal_mammary_gland0.44974503
173MP0003279_aneurysm0.44362030
174MP0003763_abnormal_thymus_physiology0.44083258
175MP0004133_heterotaxia0.43023815
176MP0002932_abnormal_joint_morphology0.41914852
177MP0009643_abnormal_urine_homeostasis0.41550435
178MP0008469_abnormal_protein_level0.40533756
179MP0008058_abnormal_DNA_repair0.39524690
180MP0005380_embryogenesis_phenotype0.39273477
181MP0001672_abnormal_embryogenesis/_devel0.39273477

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)6.46571583
2Abnormality of the middle phalanx of the 5th finger (HP:0004219)6.15050285
3Abnormality of the phalanges of the 5th finger (HP:0004213)5.61702337
4Short 5th finger (HP:0009237)5.14034002
5Aplasia/Hypoplasia of the 5th finger (HP:0006262)4.70826592
6Supernumerary nipples (HP:0002558)4.62000512
7Symphalangism affecting the phalanges of the hand (HP:0009773)4.60030451
8Muscle fibrillation (HP:0010546)4.35693755
9Type I diabetes mellitus (HP:0100651)4.30272825
10Tongue fasciculations (HP:0001308)4.26800442
11Asplenia (HP:0001746)3.98182927
12Aplasia/Hypoplasia of the spleen (HP:0010451)3.87502991
13Enlarged kidneys (HP:0000105)3.86402712
14Eczematoid dermatitis (HP:0000976)3.83898925
15Amblyopia (HP:0000646)3.76881406
16Failure to thrive in infancy (HP:0001531)3.69047169
17Hyperglycemia (HP:0003074)3.68718747
18Decreased circulating renin level (HP:0003351)3.56382885
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.54691934
20Absent speech (HP:0001344)3.45952369
21Mesangial abnormality (HP:0001966)3.36702205
22Esophageal varix (HP:0002040)3.35703432
23Keratoconjunctivitis (HP:0001096)3.34630300
24Polyphagia (HP:0002591)3.32795336
25Palmoplantar hyperkeratosis (HP:0000972)3.27590906
26Plantar hyperkeratosis (HP:0007556)3.22823341
27Hypercortisolism (HP:0001578)3.21802461
28Hyperactive renin-angiotensin system (HP:0000841)3.12536048
29Potter facies (HP:0002009)3.12477848
30Facial shape deformation (HP:0011334)3.12477848
31Epileptic encephalopathy (HP:0200134)3.11536547
32True hermaphroditism (HP:0010459)3.08820068
33Abnormal eating behavior (HP:0100738)3.08412251
34Generalized aminoaciduria (HP:0002909)3.07450590
35Short 1st metacarpal (HP:0010034)3.06267854
36Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.06267854
37Palmar hyperkeratosis (HP:0010765)3.03632854
38Hypergammaglobulinemia (HP:0010702)3.01289263
39Trismus (HP:0000211)2.96647764
40Tubulointerstitial fibrosis (HP:0005576)2.96073823
41Myokymia (HP:0002411)2.96030801
42Abnormality of the 1st metacarpal (HP:0010009)2.95161789
43Tetraparesis (HP:0002273)2.91434095
44Metabolic alkalosis (HP:0200114)2.90009990
45Synostosis involving the elbow (HP:0003938)2.89498391
46Humeroradial synostosis (HP:0003041)2.89498391
47Abolished electroretinogram (ERG) (HP:0000550)2.88344718
48Confusion (HP:0001289)2.87861371
49Onycholysis (HP:0001806)2.83407014
50Protruding ear (HP:0000411)2.82245196
51Intellectual disability, mild (HP:0001256)2.81774639
52Hematochezia (HP:0002573)2.81195917
53Broad nasal tip (HP:0000455)2.79585840
54Dysautonomia (HP:0002459)2.74264744
55Chronic mucocutaneous candidiasis (HP:0002728)2.71481898
56Recurrent cutaneous fungal infections (HP:0011370)2.71481898
57Synostosis involving bones of the hand (HP:0004278)2.71051655
58Clumsiness (HP:0002312)2.68352374
59Small hand (HP:0200055)2.65118114
60Abnormality of the phalanges of the hallux (HP:0010057)2.64993443
61Thin bony cortex (HP:0002753)2.64831270
62Abnormality of the middle phalanges of the toes (HP:0010183)2.63256468
63Congenital sensorineural hearing impairment (HP:0008527)2.62987104
64Gangrene (HP:0100758)2.61888812
65Abnormality of renin-angiotensin system (HP:0000847)2.58686849
66Neonatal death (HP:0003811)2.58135060
67Abnormality of the gastric mucosa (HP:0004295)2.57567174
68Absent/shortened dynein arms (HP:0200106)2.57233623
69Dynein arm defect of respiratory motile cilia (HP:0012255)2.57233623
70Alkalosis (HP:0001948)2.54294946
71Urticaria (HP:0001025)2.54114073
72Progressive microcephaly (HP:0000253)2.54060861
73Poikilocytosis (HP:0004447)2.53920066
74Reticulocytosis (HP:0001923)2.50840354
75Short phalanx of the thumb (HP:0009660)2.50360801
76Lymphangioma (HP:0100764)2.44720273
77Rib fusion (HP:0000902)2.42143060
78Right ventricular cardiomyopathy (HP:0011663)2.37621200
79Vaginal fistula (HP:0004320)2.34807138
80Gingivitis (HP:0000230)2.34612168
81Abnormality of reticulocytes (HP:0004312)2.34341672
82Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.34137362
83Short 4th metacarpal (HP:0010044)2.34137362
84Persistence of primary teeth (HP:0006335)2.33955127
85Widely patent fontanelles and sutures (HP:0004492)2.32794700
86Ankle clonus (HP:0011448)2.32162730
87Fused cervical vertebrae (HP:0002949)2.32022502
88Bony spicule pigmentary retinopathy (HP:0007737)2.31256487
89Premature loss of primary teeth (HP:0006323)2.28934570
90Wrist flexion contracture (HP:0001239)2.27016806
91Abnormality of placental membranes (HP:0011409)2.26221642
92Amniotic constriction ring (HP:0009775)2.26221642
93Milia (HP:0001056)2.26016039
94Abnormality of the costochondral junction (HP:0000919)2.25768727
95Bronchomalacia (HP:0002780)2.25736002
96Fragile skin (HP:0001030)2.25008724
97Hyperaldosteronism (HP:0000859)2.24950403
98Maternal diabetes (HP:0009800)2.23690382
99Gait imbalance (HP:0002141)2.23286153
100Round ear (HP:0100830)2.20114307
101Pustule (HP:0200039)2.19687426
102Sepsis (HP:0100806)2.18658540
103Systemic lupus erythematosus (HP:0002725)2.18521341
104Supernumerary spleens (HP:0009799)2.18031944
105Upper limb muscle weakness (HP:0003484)2.17964477
106Portal hypertension (HP:0001409)2.17210276
107Nephronophthisis (HP:0000090)2.15924680
108Lack of skin elasticity (HP:0100679)2.14417141
109Increased IgM level (HP:0003496)2.14006501
110Renal salt wasting (HP:0000127)2.13788196
111Selective tooth agenesis (HP:0001592)2.13066832
112Abnormality of B cell number (HP:0010975)2.12158966
113Hypokalemic alkalosis (HP:0001949)2.12158682
114Hemorrhage of the eye (HP:0011885)2.11686091
115Flat occiput (HP:0005469)2.10795617
116Recurrent gram-negative bacterial infections (HP:0005420)2.10560267
117Abnormal respiratory epithelium morphology (HP:0012253)2.10343498
118Abnormal respiratory motile cilium morphology (HP:0005938)2.10343498
119Cellulitis (HP:0100658)2.10265494
120Congenital primary aphakia (HP:0007707)2.09636998
121Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.08680315
122Short tibia (HP:0005736)2.08611652
123Enlarged epiphyses (HP:0010580)2.07440586
124Orchitis (HP:0100796)2.07271126
125Abnormality of midbrain morphology (HP:0002418)2.07135463
126Molar tooth sign on MRI (HP:0002419)2.07135463
127Attenuation of retinal blood vessels (HP:0007843)2.06221122
128Episodic fever (HP:0001954)2.05847072
129Hydroxyprolinuria (HP:0003080)2.05503802
130Abnormality of proline metabolism (HP:0010907)2.05503802
131Ventricular tachycardia (HP:0004756)2.05448784
132Reticulocytopenia (HP:0001896)2.05010681
133Morphological abnormality of the middle ear (HP:0008609)2.04887710
134Ankyloglossia (HP:0010296)2.04655891
135Recurrent fungal infections (HP:0002841)2.02666447
136Rectal prolapse (HP:0002035)2.02580208
137Prolonged neonatal jaundice (HP:0006579)2.02067427
138Preauricular pit (HP:0004467)2.01954105
139Periauricular skin pits (HP:0100277)2.01954105
140Ridged nail (HP:0001807)2.01305945
141Abnormality of cells of the erythroid lineage (HP:0012130)2.00684698
142Abnormality of the hepatic vasculature (HP:0006707)2.00346289
143Pancreatic fibrosis (HP:0100732)1.99631082
144Fibular aplasia (HP:0002990)1.99623620
145Increased corneal curvature (HP:0100692)1.99439728
146Keratoconus (HP:0000563)1.99439728
147Severe visual impairment (HP:0001141)1.99286559
148Stridor (HP:0010307)1.97747613
149Action tremor (HP:0002345)1.97740195
150Recurrent skin infections (HP:0001581)1.96858946
151Emotional lability (HP:0000712)1.96702442
152Neoplasm of the heart (HP:0100544)1.95818906
153Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.94704620
154Hyperventilation (HP:0002883)1.93906146
155Aplasia/Hypoplasia of the tibia (HP:0005772)1.93229656
156Fasciculations (HP:0002380)1.90783145
157Severe muscular hypotonia (HP:0006829)1.89313965
158Recurrent abscess formation (HP:0002722)1.88962387
159Hypokalemia (HP:0002900)1.87759366
160Rectovaginal fistula (HP:0000143)1.86293204
161Rectal fistula (HP:0100590)1.86293204
162Optic nerve hypoplasia (HP:0000609)1.86204064
163Delayed epiphyseal ossification (HP:0002663)1.84281468
164Sex reversal (HP:0012245)1.83306275
165Abnormal sex determination (HP:0012244)1.83306275
166Abnormality of the 4th metacarpal (HP:0010012)1.82453104
167Hypocalcemia (HP:0002901)1.82005162
168Autoimmune thrombocytopenia (HP:0001973)1.81324839
169Abnormality of the nasal mucosa (HP:0000433)1.80338893
170Intestinal fistula (HP:0100819)1.80152852
171Abnormality of the aortic arch (HP:0012303)1.78102657
172Methylmalonic aciduria (HP:0012120)1.78034448
173Loss of speech (HP:0002371)1.77579320
174Poikiloderma (HP:0001029)1.76924489
175Cerebral palsy (HP:0100021)1.76481446
176Respiratory distress (HP:0002098)1.76343101
177Malnutrition (HP:0004395)1.76058206
178Cone-rod dystrophy (HP:0000548)1.75553022
179Abnormality of the peritoneum (HP:0002585)1.75104327
180Neoplasm of the liver (HP:0002896)1.74764227
181Short femoral neck (HP:0100864)1.74127198
182Hand muscle atrophy (HP:0009130)1.73765345
183Abnormality of oral frenula (HP:0000190)1.73578414
184Coronal craniosynostosis (HP:0004440)1.73461038
185Status epilepticus (HP:0002133)1.72791422
186Decreased central vision (HP:0007663)1.72738532
187Vertebral arch anomaly (HP:0008438)1.72666591
188Ileus (HP:0002595)1.72609232
189Low posterior hairline (HP:0002162)1.71764122
190Epidermoid cyst (HP:0200040)1.71224205
191Cerebral hemorrhage (HP:0001342)1.69589290
192Myositis (HP:0100614)1.69511326

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DYRK36.54493173
2CDK194.48967853
3DYRK1B4.24052558
4MAP3K144.14821412
5KDR3.37058576
6BCR3.07340528
7ERN13.06309384
8TIE12.98400888
9MAP4K22.62327158
10SIK22.49341927
11MAP3K112.41619237
12GRK12.40957017
13NEK22.34976914
14STK102.34204529
15MST42.26129613
16TGFBR12.24933468
17SCYL21.94111763
18PRKG21.93740370
19TSSK61.90376397
20EPHA31.87213306
21LRRK21.81058135
22NEK91.65730836
23TLK11.65601349
24MAPK151.61637319
25DYRK1A1.61182144
26ERBB31.60790954
27SIK31.55914131
28MAP4K11.55639977
29TNK21.49038883
30PINK11.46989369
31PRKD21.44811381
32EPHA21.41025170
33FES1.39883492
34EPHB11.39471327
35IRAK41.36152441
36ERBB41.35524706
37GRK71.33695810
38CDK81.32593643
39MARK11.31185980
40TGFBR21.26578242
41LATS21.25755845
42FER1.22435749
43BMPR21.21528885
44TESK11.19091190
45CSNK1G31.16098574
46TESK21.11514406
47RIPK11.09706600
48VRK11.08999985
49BCKDK1.08687683
50MARK31.07175920
51MARK21.06662703
52NTRK11.05548304
53TEC1.04049081
54CHUK1.02434324
55LATS11.01471503
56PRKCQ0.97832778
57CSNK1A1L0.94664755
58CDC42BPA0.93045947
59RPS6KB20.92614533
60CDK11A0.91830614
61MAP3K80.91275646
62EPHA40.90142895
63PTK20.89333838
64STK380.88380965
65SYK0.87494763
66PRKCZ0.85943999
67FGFR40.85646670
68GRK50.83562874
69CAMKK10.83232644
70CSNK1G20.82300285
71PLK20.82016395
72ILK0.80676672
73MAP2K20.80325072
74DAPK20.78365339
75TXK0.76804670
76CAMKK20.75823501
77DYRK20.73892947
78MKNK10.72823688
79BLK0.72527160
80BMPR1B0.71233993
81CDK180.71077750
82CDK150.70445373
83TYK20.68994677
84PAK40.68604851
85EPHB20.67905626
86GRK60.67803521
87NTRK20.67609137
88CSNK1G10.66786897
89SMG10.66703738
90PLK30.66079398
91PTK60.65786964
92CAMK40.65562143
93PRKCD0.65096956
94PAK60.63735418
95MATK0.63514585
96OXSR10.63436630
97CDK70.63127059
98STK38L0.62533465
99ERBB20.62276756
100NTRK30.62200814
101DAPK10.62004564
102MYLK0.61822514
103MAP3K60.61462583
104PDPK10.61450840
105PDGFRA0.61342138
106TTK0.61083776
107BUB10.59521607
108CDK50.57743237
109IKBKB0.55523304
110ALK0.55006604
111CDK140.54597437
112CSK0.53999439
113SIK10.51471901
114MAP2K60.51253464
115NEK10.50933477
116HCK0.50688277
117STK240.50211217
118PASK0.49656552
119BRSK10.48442021
120KSR10.45059988
121CDK90.44526512
122ROCK20.44471664
123EIF2AK20.44396733
124KSR20.43631447
125EGFR0.43462030
126FGFR30.43193586
127PTK2B0.42901177
128MAP3K70.42795789
129MAP3K10.42747948
130MAPK70.42716907
131TAOK10.42524803
132KIT0.42000804
133WEE10.41785472
134WNK30.41537244
135ABL20.41275834
136UHMK10.40390058
137MAPK110.40284634
138MAPK130.39926900
139STK110.39897088
140MKNK20.37948689
141SRC0.37740548
142TBK10.37459248
143LIMK10.37260880
144JAK20.35687276
145MAPK120.35231021
146PAK10.35087607
147PRKCG0.34586954
148PIM20.34333382
149MAPK80.33864512
150MAPKAPK20.33417992
151BTK0.33359694
152MAP3K30.33012078
153IKBKE0.32075079
154MAPKAPK30.31807739
155MAP2K40.31607002
156GSK3A0.31601472
157PRKD30.31282240
158LMTK20.31089918
159WNK40.31028344
160CAMK10.30962392
161DDR20.30670463
162MELK0.30591832
163MTOR0.30330792
164PRKDC0.30008522
165PRKAA10.29901414
166PRKACG0.29740352
167FGFR20.28434481
168PDK20.26757918
169CSNK2A20.25456763
170PAK20.25355734
171MAP3K100.24389806
172MAP2K10.23123243

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.80463046
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004005.54055610
3Histidine metabolism_Homo sapiens_hsa003404.76307735
4Sulfur relay system_Homo sapiens_hsa041223.53837718
5Antigen processing and presentation_Homo sapiens_hsa046123.01372844
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.68914093
7Linoleic acid metabolism_Homo sapiens_hsa005912.65669441
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.60194690
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.58440850
10Renin-angiotensin system_Homo sapiens_hsa046142.52985654
11Phenylalanine metabolism_Homo sapiens_hsa003602.39508994
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.18656149
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.10206469
14Other glycan degradation_Homo sapiens_hsa005111.95892549
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82304688
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.77274729
17Arginine biosynthesis_Homo sapiens_hsa002201.75042954
18Collecting duct acid secretion_Homo sapiens_hsa049661.72347014
19Fat digestion and absorption_Homo sapiens_hsa049751.69757533
20Nicotine addiction_Homo sapiens_hsa050331.65397872
21Morphine addiction_Homo sapiens_hsa050321.59930804
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.59755886
23p53 signaling pathway_Homo sapiens_hsa041151.57426096
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.56464153
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.53427721
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.48291982
27Synaptic vesicle cycle_Homo sapiens_hsa047211.47132669
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.46939064
29Sulfur metabolism_Homo sapiens_hsa009201.45454176
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.45371974
31Proteasome_Homo sapiens_hsa030501.39666929
32Adherens junction_Homo sapiens_hsa045201.35201068
33Cocaine addiction_Homo sapiens_hsa050301.34839208
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.31356014
35Chemokine signaling pathway_Homo sapiens_hsa040621.25284286
36GABAergic synapse_Homo sapiens_hsa047271.24127298
37Ribosome_Homo sapiens_hsa030101.23429084
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22854457
39Circadian entrainment_Homo sapiens_hsa047131.22576818
40Staphylococcus aureus infection_Homo sapiens_hsa051501.22438521
41Folate biosynthesis_Homo sapiens_hsa007901.21696244
42Dopaminergic synapse_Homo sapiens_hsa047281.18751233
43Lysosome_Homo sapiens_hsa041421.16945503
44Leishmaniasis_Homo sapiens_hsa051401.13671922
45Regulation of autophagy_Homo sapiens_hsa041401.13622212
46African trypanosomiasis_Homo sapiens_hsa051431.13607148
47Basal cell carcinoma_Homo sapiens_hsa052171.11886966
48Mineral absorption_Homo sapiens_hsa049781.09493859
49Starch and sucrose metabolism_Homo sapiens_hsa005001.09141700
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08712349
51Taste transduction_Homo sapiens_hsa047421.08200851
52Gastric acid secretion_Homo sapiens_hsa049711.07448835
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05991965
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04972908
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04813014
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04276471
57Hippo signaling pathway_Homo sapiens_hsa043901.03514717
58Insulin secretion_Homo sapiens_hsa049111.02659444
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02433037
60Olfactory transduction_Homo sapiens_hsa047401.01904274
61Primary immunodeficiency_Homo sapiens_hsa053400.97214704
62Retinol metabolism_Homo sapiens_hsa008300.92733360
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92671091
64Focal adhesion_Homo sapiens_hsa045100.90583854
65Arachidonic acid metabolism_Homo sapiens_hsa005900.90551622
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90337420
67ECM-receptor interaction_Homo sapiens_hsa045120.85574786
68Cholinergic synapse_Homo sapiens_hsa047250.84472721
69Osteoclast differentiation_Homo sapiens_hsa043800.84203268
70Chemical carcinogenesis_Homo sapiens_hsa052040.84039682
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84037928
72Asthma_Homo sapiens_hsa053100.82266522
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81257914
74Legionellosis_Homo sapiens_hsa051340.80365020
75HTLV-I infection_Homo sapiens_hsa051660.80229487
76Tight junction_Homo sapiens_hsa045300.79147438
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.78389188
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77907501
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77766615
80Fructose and mannose metabolism_Homo sapiens_hsa000510.77516778
81DNA replication_Homo sapiens_hsa030300.76832367
82Tyrosine metabolism_Homo sapiens_hsa003500.76778610
83Salivary secretion_Homo sapiens_hsa049700.75296492
84Cell cycle_Homo sapiens_hsa041100.74860758
85Glutamatergic synapse_Homo sapiens_hsa047240.73062482
86ABC transporters_Homo sapiens_hsa020100.72319699
87Vitamin digestion and absorption_Homo sapiens_hsa049770.70949085
88MicroRNAs in cancer_Homo sapiens_hsa052060.70879623
89Apoptosis_Homo sapiens_hsa042100.70466634
90Amphetamine addiction_Homo sapiens_hsa050310.70005853
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69727825
92Small cell lung cancer_Homo sapiens_hsa052220.69403875
93Hedgehog signaling pathway_Homo sapiens_hsa043400.69110995
94Serotonergic synapse_Homo sapiens_hsa047260.68533647
95Proteoglycans in cancer_Homo sapiens_hsa052050.67943493
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66575894
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65170777
98* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64858475
99Tuberculosis_Homo sapiens_hsa051520.64237497
100Nitrogen metabolism_Homo sapiens_hsa009100.63871161
101Renin secretion_Homo sapiens_hsa049240.63173739
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62889951
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61719733
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61262680
105Rheumatoid arthritis_Homo sapiens_hsa053230.59116715
106Rap1 signaling pathway_Homo sapiens_hsa040150.58665028
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58317401
108Pathways in cancer_Homo sapiens_hsa052000.57379491
109Homologous recombination_Homo sapiens_hsa034400.56949716
110Prion diseases_Homo sapiens_hsa050200.56729279
111Bile secretion_Homo sapiens_hsa049760.56520295
112Ras signaling pathway_Homo sapiens_hsa040140.56412805
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56355085
114Viral carcinogenesis_Homo sapiens_hsa052030.56276642
115PPAR signaling pathway_Homo sapiens_hsa033200.55469943
116Vibrio cholerae infection_Homo sapiens_hsa051100.52831303
117AMPK signaling pathway_Homo sapiens_hsa041520.52758724
118Calcium signaling pathway_Homo sapiens_hsa040200.51736237
119Pertussis_Homo sapiens_hsa051330.51062306
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50141770
121* Intestinal immune network for IgA production_Homo sapiens_hsa046720.50056656
122Ether lipid metabolism_Homo sapiens_hsa005650.49968356
123Mismatch repair_Homo sapiens_hsa034300.49932164
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49121845
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.49089928
126cAMP signaling pathway_Homo sapiens_hsa040240.48560184
127Thyroid hormone synthesis_Homo sapiens_hsa049180.48254388
128Phagosome_Homo sapiens_hsa041450.48172590
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46826040
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46670767
131Toxoplasmosis_Homo sapiens_hsa051450.46603679
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45922176
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45807959
134Glycerolipid metabolism_Homo sapiens_hsa005610.45701750
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.45477304
136Fatty acid biosynthesis_Homo sapiens_hsa000610.44514960
137NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44260800
138Amoebiasis_Homo sapiens_hsa051460.43212473
139Galactose metabolism_Homo sapiens_hsa000520.41876275
140Phototransduction_Homo sapiens_hsa047440.41733255
141Biosynthesis of amino acids_Homo sapiens_hsa012300.41302098
142Endometrial cancer_Homo sapiens_hsa052130.41243114
143FoxO signaling pathway_Homo sapiens_hsa040680.40560063
1442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38409236
145RNA transport_Homo sapiens_hsa030130.38280897
146VEGF signaling pathway_Homo sapiens_hsa043700.38167865
147Gap junction_Homo sapiens_hsa045400.37686066
148Alcoholism_Homo sapiens_hsa050340.37082677
149Pancreatic secretion_Homo sapiens_hsa049720.37065704
150Endocytosis_Homo sapiens_hsa041440.36989400
151Bladder cancer_Homo sapiens_hsa052190.36736617
152TNF signaling pathway_Homo sapiens_hsa046680.34675676
153Thyroid cancer_Homo sapiens_hsa052160.33957323
154Choline metabolism in cancer_Homo sapiens_hsa052310.32105208
155Epstein-Barr virus infection_Homo sapiens_hsa051690.31695909
156Allograft rejection_Homo sapiens_hsa053300.31412129
157Spliceosome_Homo sapiens_hsa030400.31409621
158Type I diabetes mellitus_Homo sapiens_hsa049400.30485282
159Melanoma_Homo sapiens_hsa052180.30333647
160Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29248479
161TGF-beta signaling pathway_Homo sapiens_hsa043500.29168863
162Glycerophospholipid metabolism_Homo sapiens_hsa005640.29023469
163Arginine and proline metabolism_Homo sapiens_hsa003300.28200375
164Inositol phosphate metabolism_Homo sapiens_hsa005620.26820807
165Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26610977
166MAPK signaling pathway_Homo sapiens_hsa040100.24952350
167Protein digestion and absorption_Homo sapiens_hsa049740.24889005

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