MADD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.24055262
2synaptic vesicle maturation (GO:0016188)5.97219507
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.79631121
4locomotory exploration behavior (GO:0035641)5.09696928
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.08570433
6synaptic vesicle exocytosis (GO:0016079)5.06493419
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.02938147
8regulation of synaptic vesicle exocytosis (GO:2000300)4.98595694
9glutamate secretion (GO:0014047)4.57823434
10regulation of synaptic vesicle transport (GO:1902803)4.46565085
11cellular potassium ion homeostasis (GO:0030007)4.32907655
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.27949496
13negative regulation of erythrocyte differentiation (GO:0045647)4.27463829
14vocalization behavior (GO:0071625)4.21307693
15regulation of glutamate receptor signaling pathway (GO:1900449)4.17267768
16sodium ion export (GO:0071436)4.10949048
17protein localization to synapse (GO:0035418)4.08625249
18neurotransmitter secretion (GO:0007269)4.05660026
19regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.99506767
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.92865337
21regulation of ARF protein signal transduction (GO:0032012)3.86938652
22cerebellar Purkinje cell differentiation (GO:0021702)3.82978674
23response to pheromone (GO:0019236)3.79268940
24L-amino acid import (GO:0043092)3.71191202
25regulation of neuronal synaptic plasticity (GO:0048168)3.70314882
26exploration behavior (GO:0035640)3.67058003
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.65048397
28cerebellar granule cell differentiation (GO:0021707)3.64190958
29synaptic vesicle endocytosis (GO:0048488)3.63028069
30positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.60179464
31retinal cone cell development (GO:0046549)3.54458493
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.52858225
33synaptic transmission, glutamatergic (GO:0035249)3.52654399
34positive regulation of membrane potential (GO:0045838)3.50619552
35long-term memory (GO:0007616)3.49079116
36cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.46399503
37layer formation in cerebral cortex (GO:0021819)3.46344391
38activation of protein kinase A activity (GO:0034199)3.45240188
39neurotransmitter-gated ion channel clustering (GO:0072578)3.41163179
40neuronal action potential propagation (GO:0019227)3.38859111
41regulation of synapse structural plasticity (GO:0051823)3.37695714
42chemosensory behavior (GO:0007635)3.34887601
43regulation of neurotransmitter secretion (GO:0046928)3.34656572
44positive regulation of Rap GTPase activity (GO:0032854)3.34576757
45neuron-neuron synaptic transmission (GO:0007270)3.30481347
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.30018726
47neurotransmitter transport (GO:0006836)3.29590505
48cytoskeletal anchoring at plasma membrane (GO:0007016)3.28352143
49regulation of postsynaptic membrane potential (GO:0060078)3.26079166
50glutamate receptor signaling pathway (GO:0007215)3.24448827
51neuron cell-cell adhesion (GO:0007158)3.24015729
52positive regulation of synapse maturation (GO:0090129)3.23146576
53proline transport (GO:0015824)3.22876170
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.21558485
55neuromuscular process controlling posture (GO:0050884)3.20573741
56amino acid import (GO:0043090)3.13590360
57regulation of clathrin-mediated endocytosis (GO:2000369)3.11889860
58regulation of rhodopsin mediated signaling pathway (GO:0022400)3.10184587
59membrane hyperpolarization (GO:0060081)3.10111852
60regulation of ARF GTPase activity (GO:0032312)3.09668641
61gamma-aminobutyric acid transport (GO:0015812)3.09580924
62long-term synaptic potentiation (GO:0060291)3.09504273
63photoreceptor cell development (GO:0042461)3.08361899
64rhodopsin mediated signaling pathway (GO:0016056)3.06451805
65regulation of vesicle fusion (GO:0031338)3.04868821
66cell communication by electrical coupling (GO:0010644)3.04581870
67potassium ion import (GO:0010107)3.02261514
68regulation of calcium ion-dependent exocytosis (GO:0017158)3.02085843
69negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.00524797
70negative regulation of cell killing (GO:0031342)3.00524797
71G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.00096903
72membrane depolarization during action potential (GO:0086010)3.00035948
73regulation of neurotransmitter transport (GO:0051588)2.99557889
74innervation (GO:0060384)2.99247105
75regulation of synaptic plasticity (GO:0048167)2.99199679
76eye photoreceptor cell development (GO:0042462)2.99135552
77positive regulation of neurotransmitter transport (GO:0051590)2.98939925
78retinal rod cell development (GO:0046548)2.97704971
79positive regulation of synaptic transmission, GABAergic (GO:0032230)2.95675311
80vesicle transport along microtubule (GO:0047496)2.95477937
81regulation of Rap GTPase activity (GO:0032317)2.95319404
82gamma-aminobutyric acid signaling pathway (GO:0007214)2.95162262
83potassium ion homeostasis (GO:0055075)2.94924649
84neuronal ion channel clustering (GO:0045161)2.91816501
85positive regulation of gamma-delta T cell activation (GO:0046645)2.91237139
86negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.91188553
87regulation of neurotransmitter levels (GO:0001505)2.90978585
88positive regulation of neurotransmitter secretion (GO:0001956)2.90701782
89signal complex assembly (GO:0007172)2.89177817
90detection of light stimulus involved in visual perception (GO:0050908)2.87519121
91detection of light stimulus involved in sensory perception (GO:0050962)2.87519121
92dendritic spine morphogenesis (GO:0060997)2.86663257
93insulin secretion (GO:0030073)2.85780325
94positive regulation of exocytosis (GO:0045921)2.84007203
95positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.80185824
96membrane depolarization (GO:0051899)2.78536020
97response to histamine (GO:0034776)2.78453462
98regulation of voltage-gated calcium channel activity (GO:1901385)2.76048135
99neuromuscular process controlling balance (GO:0050885)2.75516428
100positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.74786461
101regulation of synaptic transmission, glutamatergic (GO:0051966)2.74372828
102prepulse inhibition (GO:0060134)2.72935739
103G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72363741
104regulation of exocytosis (GO:0017157)2.71887147
105dendrite morphogenesis (GO:0048813)2.70267699
106detection of calcium ion (GO:0005513)2.69249814
107regulation of synapse maturation (GO:0090128)2.69082769
108transmission of nerve impulse (GO:0019226)2.67976905
109positive regulation of synaptic transmission (GO:0050806)2.66883816
110synaptic vesicle transport (GO:0048489)2.65805420
111establishment of synaptic vesicle localization (GO:0097480)2.65805420
112protein localization to endosome (GO:0036010)2.65601714
113cellular sodium ion homeostasis (GO:0006883)2.64789474
114regulation of regulated secretory pathway (GO:1903305)2.58766896
115mannose metabolic process (GO:0006013)2.55223090
116negative regulation of dendrite morphogenesis (GO:0050774)2.51700025
117regulation of T-helper 2 cell differentiation (GO:0045628)2.50356124
118adenosine receptor signaling pathway (GO:0001973)2.43388285
119regulation of beta-amyloid formation (GO:1902003)2.41998067
120regulation of gamma-delta T cell differentiation (GO:0045586)2.38553602
121regulation of gamma-delta T cell activation (GO:0046643)2.36326999
122cellular response to catecholamine stimulus (GO:0071870)2.34988025
123cellular response to monoamine stimulus (GO:0071868)2.34988025
124positive regulation of protein dephosphorylation (GO:0035307)2.34552581
125positive regulation of dendritic spine development (GO:0060999)2.34365520
126regulation of leukocyte degranulation (GO:0043300)2.31994216
127dopamine receptor signaling pathway (GO:0007212)2.29064760
128cell differentiation in hindbrain (GO:0021533)2.27298425
129regulation of amyloid precursor protein catabolic process (GO:1902991)2.26411752
130negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.26198854
131response to muramyl dipeptide (GO:0032495)2.24687654
132peptidyl-tyrosine autophosphorylation (GO:0038083)2.24191124
133regulation of early endosome to late endosome transport (GO:2000641)2.23791766
134positive regulation of fibroblast migration (GO:0010763)2.18920078
135regulation of NFAT protein import into nucleus (GO:0051532)2.17230039
136positive regulation of regulated secretory pathway (GO:1903307)2.15851165
137regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.15487255

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.56927495
2DROSHA_22980978_ChIP-Seq_HELA_Human2.94470926
3GBX2_23144817_ChIP-Seq_PC3_Human2.93401636
4REST_21632747_ChIP-Seq_MESCs_Mouse2.85739987
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.72030378
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46385078
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.36561774
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.30943071
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.30924712
10* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30388643
11LXR_22292898_ChIP-Seq_THP-1_Human2.29606730
12* REST_18959480_ChIP-ChIP_MESCs_Mouse2.29459340
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.21219550
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.20208817
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17127301
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.12062068
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08338563
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07332677
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03863121
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03863121
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98072639
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96221087
23VDR_21846776_ChIP-Seq_THP-1_Human1.95440138
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.93489248
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.91430852
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.91268321
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86203910
28MYC_22102868_ChIP-Seq_BL_Human1.82528229
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80349715
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.80146451
31SCL_19346495_ChIP-Seq_HPC-7_Human1.75416195
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73865803
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73468697
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.71104337
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.66579562
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65834762
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.65132413
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57235292
39TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.51796643
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51601188
41SMAD4_21799915_ChIP-Seq_A2780_Human1.50634675
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.50432047
43VDR_24763502_ChIP-Seq_THP-1_Human1.50108928
44GATA1_19941826_ChIP-Seq_K562_Human1.49229145
45* SMC4_20622854_ChIP-Seq_HELA_Human1.46572214
46* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45587105
47KDM2B_26808549_Chip-Seq_K562_Human1.44418437
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.43854739
49GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43774841
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42819804
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.42749763
52AR_21572438_ChIP-Seq_LNCaP_Human1.41353077
53IGF1R_20145208_ChIP-Seq_DFB_Human1.39170392
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37731711
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36651779
56AR_19668381_ChIP-Seq_PC3_Human1.34493229
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.34309397
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33262089
59CREB1_26743006_Chip-Seq_LNCaP_Human1.31799106
60RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31556707
61RACK7_27058665_Chip-Seq_MCF-7_Human1.31203199
62P68_20966046_ChIP-Seq_HELA_Human1.30090086
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29664728
64STAT3_23295773_ChIP-Seq_U87_Human1.27905752
65MAF_26560356_Chip-Seq_TH1_Human1.26380851
66* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25690903
67CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24971935
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24671763
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24465904
70* RUNX1_22412390_ChIP-Seq_EML_Mouse1.23339153
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22713273
72DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22326227
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.20942118
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19959629
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19574645
76NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19467460
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.19226847
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18816295
79UTX_26944678_Chip-Seq_JUKART_Human1.18631020
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17477262
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17428158
82KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16774895
83RUNX_20019798_ChIP-Seq_JUKART_Human1.12556039
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10367667
85TCF4_23295773_ChIP-Seq_U87_Human1.10217260
86OCT4_19829295_ChIP-Seq_ESCs_Human1.10183711
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09918926
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.09887031
89STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09876007
90RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09725345
91ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09539049
92KDM2B_26808549_Chip-Seq_DND41_Human1.08780949
93CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08602949
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05890813
95* CTCF_27219007_Chip-Seq_Bcells_Human1.05772155
96AR_25329375_ChIP-Seq_VCAP_Human1.05472155
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05392247
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05163059
99MAF_26560356_Chip-Seq_TH2_Human1.04737161
100KDM2B_26808549_Chip-Seq_JURKAT_Human1.04620562
101YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03828183
102GATA2_19941826_ChIP-Seq_K562_Human1.03804351
103SA1_27219007_Chip-Seq_ERYTHROID_Human1.03169742
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02778106
105EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02374792
106SMAD3_21741376_ChIP-Seq_ESCs_Human1.01962426
107SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01238521
108ARNT_22903824_ChIP-Seq_MCF-7_Human1.00170798
109AHR_22903824_ChIP-Seq_MCF-7_Human1.00088546
110P300_19829295_ChIP-Seq_ESCs_Human0.98212262
111* IRF8_27001747_Chip-Seq_BMDM_Mouse0.97528065
112RING1B_27294783_Chip-Seq_ESCs_Mouse0.96614605
113FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95894438
114BCOR_27268052_Chip-Seq_Bcells_Human0.95231247
115ZNF274_21170338_ChIP-Seq_K562_Hela0.94874077
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94380857
117RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94223747
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93543030
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93410628
120SPI1_23127762_ChIP-Seq_K562_Human0.93374927
121GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92535061
122KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92521380
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92209323
124* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90937870
125* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90924507
126ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90463872
127* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90176420
128ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89898597
129* SMAD4_21741376_ChIP-Seq_HESCs_Human0.88973112
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86831952
131SMAD3_21741376_ChIP-Seq_EPCs_Human0.86814344
132WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86772008
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86466127
134CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86325701
135RXR_22108803_ChIP-Seq_LS180_Human0.85641959
136* TET1_21490601_ChIP-Seq_MESCs_Mouse0.85467127
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85359904
138TCF7_22412390_ChIP-Seq_EML_Mouse0.85019961
139* SMAD3_21741376_ChIP-Seq_HESCs_Human0.84763821
140FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.83614008
141THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83347171
142PRDM14_20953172_ChIP-Seq_ESCs_Human0.83313004
143GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83198818
144TAF15_26573619_Chip-Seq_HEK293_Human0.83101534
145RING1B_27294783_Chip-Seq_NPCs_Mouse0.83025898
146* GATA1_19941827_ChIP-Seq_MEL_Mouse0.82825448
147BCAT_22108803_ChIP-Seq_LS180_Human0.82324155

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.73569093
2* MP0003635_abnormal_synaptic_transmissio3.65802428
3MP0003880_abnormal_central_pattern3.30274483
4MP0005551_abnormal_eye_electrophysiolog3.28611338
5MP0004270_analgesia3.18501120
6MP0005423_abnormal_somatic_nervous2.99635187
7MP0009745_abnormal_behavioral_response2.82735280
8MP0002063_abnormal_learning/memory/cond2.81794710
9MP0002064_seizures2.73178866
10MP0002909_abnormal_adrenal_gland2.69936043
11MP0009046_muscle_twitch2.64984626
12MP0001968_abnormal_touch/_nociception2.46976043
13MP0006072_abnormal_retinal_apoptosis2.45757298
14MP0002572_abnormal_emotion/affect_behav2.43720230
15MP0009780_abnormal_chondrocyte_physiolo2.43566031
16MP0000569_abnormal_digit_pigmentation2.35223525
17MP0003690_abnormal_glial_cell2.29109300
18MP0001486_abnormal_startle_reflex2.24608772
19* MP0002272_abnormal_nervous_system2.19865997
20MP0005058_abnormal_lysosome_morphology2.19410069
21MP0001501_abnormal_sleep_pattern2.11152935
22MP0005253_abnormal_eye_physiology2.10699867
23MP0008569_lethality_at_weaning2.02080014
24* MP0002734_abnormal_mechanical_nocicepti2.01786681
25MP0001984_abnormal_olfaction2.00037720
26MP0002822_catalepsy1.96372076
27MP0005646_abnormal_pituitary_gland1.93271549
28MP0003787_abnormal_imprinting1.85677373
29MP0001502_abnormal_circadian_rhythm1.85378903
30MP0003436_decreased_susceptibility_to1.83508722
31MP0003172_abnormal_lysosome_physiology1.83443886
32MP0008961_abnormal_basal_metabolism1.81948148
33MP0003183_abnormal_peptide_metabolism1.80095772
34MP0005409_darkened_coat_color1.79958039
35MP0000920_abnormal_myelination1.76923220
36MP0002067_abnormal_sensory_capabilities1.75880553
37MP0005464_abnormal_platelet_physiology1.74364998
38MP0002735_abnormal_chemical_nociception1.70230534
39MP0004811_abnormal_neuron_physiology1.66833627
40MP0002733_abnormal_thermal_nociception1.66388677
41MP0002736_abnormal_nociception_after1.62996873
42MP0003283_abnormal_digestive_organ1.62360645
43MP0003879_abnormal_hair_cell1.61476382
44MP0002229_neurodegeneration1.58759875
45MP0008260_abnormal_autophagy1.58305520
46* MP0001970_abnormal_pain_threshold1.55705939
47MP0004885_abnormal_endolymph1.55410177
48MP0004924_abnormal_behavior1.55096337
49MP0005386_behavior/neurological_phenoty1.55096337
50MP0002557_abnormal_social/conspecific_i1.54599948
51MP0003123_paternal_imprinting1.54061953
52MP0001348_abnormal_lacrimal_gland1.53994612
53MP0002638_abnormal_pupillary_reflex1.52078683
54MP0002090_abnormal_vision1.49996569
55MP0005645_abnormal_hypothalamus_physiol1.47669595
56MP0002184_abnormal_innervation1.47396506
57MP0004130_abnormal_muscle_cell1.46677718
58MP0009278_abnormal_bone_marrow1.45527818
59MP0010386_abnormal_urinary_bladder1.44623641
60MP0001440_abnormal_grooming_behavior1.42580919
61* MP0002882_abnormal_neuron_morphology1.41748580
62MP0003633_abnormal_nervous_system1.39140319
63MP0002693_abnormal_pancreas_physiology1.33173669
64MP0003191_abnormal_cellular_cholesterol1.26753785
65MP0000955_abnormal_spinal_cord1.26708975
66MP0003011_delayed_dark_adaptation1.26376136
67MP0005451_abnormal_body_composition1.24254980
68MP0004510_myositis1.24247638
69MP0001986_abnormal_taste_sensitivity1.20577770
70MP0003329_amyloid_beta_deposits1.20074327
71MP0004858_abnormal_nervous_system1.18026286
72MP0002066_abnormal_motor_capabilities/c1.15828523
73MP0003122_maternal_imprinting1.14394183
74MP0003763_abnormal_thymus_physiology1.13703517
75MP0004947_skin_inflammation1.09792550
76MP0005000_abnormal_immune_tolerance1.09187431
77MP0005499_abnormal_olfactory_system1.07773387
78MP0005394_taste/olfaction_phenotype1.07773387
79MP0000015_abnormal_ear_pigmentation1.07587654
80MP0004043_abnormal_pH_regulation1.07101591
81MP0006276_abnormal_autonomic_nervous1.06995903
82MP0002877_abnormal_melanocyte_morpholog1.06485501
83MP0005195_abnormal_posterior_eye1.05088721
84MP0002419_abnormal_innate_immunity1.03793644
85MP0001944_abnormal_pancreas_morphology1.03783055
86MP0009840_abnormal_foam_cell1.03540096
87MP0000778_abnormal_nervous_system1.02931236
88MP0005535_abnormal_body_temperature1.00516675
89MP0003632_abnormal_nervous_system0.98169085
90MP0002998_abnormal_bone_remodeling0.97885736
91MP0000013_abnormal_adipose_tissue0.96920748
92MP0003631_nervous_system_phenotype0.94763260
93MP0002069_abnormal_eating/drinking_beha0.94007934
94MP0005310_abnormal_salivary_gland0.93720309
95MP0005025_abnormal_response_to0.90244775
96MP0001851_eye_inflammation0.89786808
97MP0001835_abnormal_antigen_presentation0.88537939
98MP0003045_fibrosis0.88127929
99MP0003075_altered_response_to0.85913869
100MP0005076_abnormal_cell_differentiation0.85413315
101MP0003724_increased_susceptibility_to0.83834663
102MP0002152_abnormal_brain_morphology0.83184652
103MP0004742_abnormal_vestibular_system0.83041969
104* MP0002752_abnormal_somatic_nervous0.82585456
105MP0002420_abnormal_adaptive_immunity0.81725723
106MP0005397_hematopoietic_system_phenotyp0.81410527
107MP0001545_abnormal_hematopoietic_system0.81410527
108MP0003705_abnormal_hypodermis_morpholog0.81262892
109MP0008872_abnormal_physiological_respon0.80544425
110MP0000631_abnormal_neuroendocrine_gland0.80504619
111MP0001800_abnormal_humoral_immune0.80464814
112MP0005166_decreased_susceptibility_to0.80029347
113MP0003866_abnormal_defecation0.79687712
114MP0001819_abnormal_immune_cell0.79551192
115MP0003091_abnormal_cell_migration0.79381980
116MP0002723_abnormal_immune_serum0.79363082
117MP0005671_abnormal_response_to0.77790990
118MP0003300_gastrointestinal_ulcer0.77298302
119MP0008874_decreased_physiological_sensi0.77067647
120MP0006082_CNS_inflammation0.75835189
121MP0001324_abnormal_eye_pigmentation0.75415022
122MP0002078_abnormal_glucose_homeostasis0.74642726
123MP0005379_endocrine/exocrine_gland_phen0.74056984
124MP0002398_abnormal_bone_marrow0.73318848
125MP0002234_abnormal_pharynx_morphology0.73026830
126MP0003828_pulmonary_edema0.72751631
127MP0006292_abnormal_olfactory_placode0.72390652
128MP0001188_hyperpigmentation0.72083380
129MP0005167_abnormal_blood-brain_barrier0.71857174
130MP0005666_abnormal_adipose_tissue0.69744998
131MP0004085_abnormal_heartbeat0.69660770
132MP0003634_abnormal_glial_cell0.69239084
133MP0002452_abnormal_antigen_presenting0.68601483
134MP0001790_abnormal_immune_system0.67913673
135MP0005387_immune_system_phenotype0.67913673
136MP0001765_abnormal_ion_homeostasis0.67563166
137MP0004142_abnormal_muscle_tone0.66670762
138MP0001963_abnormal_hearing_physiology0.64707926
139MP0004145_abnormal_muscle_electrophysio0.64606874
140MP0002928_abnormal_bile_duct0.64410931
141MP0005391_vision/eye_phenotype0.63178771
142MP0003868_abnormal_feces_composition0.62106262
143MP0000604_amyloidosis0.60385501
144MP0003953_abnormal_hormone_level0.59343483
145MP0003303_peritoneal_inflammation0.58825553

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.64102210
2Visual hallucinations (HP:0002367)5.10426531
3Focal motor seizures (HP:0011153)5.06660912
4Central scotoma (HP:0000603)4.42645119
5Bony spicule pigmentary retinopathy (HP:0007737)4.37390135
6Abnormal rod and cone electroretinograms (HP:0008323)4.31691564
7Absent rod-and cone-mediated responses on ERG (HP:0007688)4.31295049
8Epileptic encephalopathy (HP:0200134)4.18034782
9Focal seizures (HP:0007359)4.13141065
10Myokymia (HP:0002411)4.12024072
11Febrile seizures (HP:0002373)4.08079450
12Neurofibrillary tangles (HP:0002185)3.89986349
13Obstructive sleep apnea (HP:0002870)3.83449136
14Abnormality of macular pigmentation (HP:0008002)3.78641370
15Progressive cerebellar ataxia (HP:0002073)3.73365457
16Atonic seizures (HP:0010819)3.45718921
17Absence seizures (HP:0002121)3.43074036
18Cerebral inclusion bodies (HP:0100314)3.42291834
19Dyschromatopsia (HP:0007641)3.32332137
20Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.28870619
21Decreased central vision (HP:0007663)3.22077714
22Scotoma (HP:0000575)3.17928184
23Supranuclear gaze palsy (HP:0000605)3.16452258
24Action tremor (HP:0002345)3.12182753
25Annular pancreas (HP:0001734)3.11464851
26Truncal ataxia (HP:0002078)3.08253540
27Papilledema (HP:0001085)3.05953953
28Genetic anticipation (HP:0003743)3.03251582
29Depression (HP:0000716)3.02623669
30Dialeptic seizures (HP:0011146)2.98211262
31Impaired smooth pursuit (HP:0007772)2.90346024
32Gaze-evoked nystagmus (HP:0000640)2.86984695
33Severe visual impairment (HP:0001141)2.84207484
34Generalized tonic-clonic seizures (HP:0002069)2.80012055
35Type II diabetes mellitus (HP:0005978)2.71852169
36Apathy (HP:0000741)2.68046703
37Ankle clonus (HP:0011448)2.66188487
38Agitation (HP:0000713)2.64396657
39Peripheral hypomyelination (HP:0007182)2.64018644
40Postural instability (HP:0002172)2.63687630
41Abnormality of ocular smooth pursuit (HP:0000617)2.61002537
42Dysdiadochokinesis (HP:0002075)2.59369891
43Urinary bladder sphincter dysfunction (HP:0002839)2.57847586
44Abolished electroretinogram (ERG) (HP:0000550)2.56588984
45Broad-based gait (HP:0002136)2.56347984
46Attenuation of retinal blood vessels (HP:0007843)2.55921959
47Poor eye contact (HP:0000817)2.54998107
48Pendular nystagmus (HP:0012043)2.52700906
49Abnormal social behavior (HP:0012433)2.51788445
50Impaired social interactions (HP:0000735)2.51788445
51Diplopia (HP:0000651)2.50911297
52Abnormality of binocular vision (HP:0011514)2.50911297
53Slow saccadic eye movements (HP:0000514)2.48713659
54Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.45185194
55Pigmentary retinal degeneration (HP:0001146)2.42203393
56Diminished motivation (HP:0000745)2.41897318
57Hemiplegia (HP:0002301)2.41533624
58Dysostosis multiplex (HP:0000943)2.40090976
59Eczematoid dermatitis (HP:0000976)2.39984739
60Mutism (HP:0002300)2.38401192
61Macroorchidism (HP:0000053)2.38152402
62Anxiety (HP:0000739)2.37032517
63Epileptiform EEG discharges (HP:0011182)2.37024863
64EEG with generalized epileptiform discharges (HP:0011198)2.36996307
65Tetraplegia (HP:0002445)2.34266336
66Dysmetric saccades (HP:0000641)2.33329184
67Photophobia (HP:0000613)2.32304097
68Prolonged bleeding time (HP:0003010)2.31867374
69Impaired vibration sensation in the lower limbs (HP:0002166)2.28472595
70Distal upper limb amyotrophy (HP:0007149)2.27224469
71Upper limb amyotrophy (HP:0009129)2.27224469
72Abnormality of the lower motor neuron (HP:0002366)2.25707941
73Dysmetria (HP:0001310)2.22786090
74Rapidly progressive (HP:0003678)2.20681300
75Hypsarrhythmia (HP:0002521)2.18923908
76Excessive salivation (HP:0003781)2.16817135
77Drooling (HP:0002307)2.16817135
78Scanning speech (HP:0002168)2.15274779
79Bradykinesia (HP:0002067)2.14750593
80Hand muscle atrophy (HP:0009130)2.12437952
81Constricted visual fields (HP:0001133)2.12384485
82Rigidity (HP:0002063)2.11904920
83Macular degeneration (HP:0000608)2.11734841
84Cerebral aneurysm (HP:0004944)2.11411949
85Abnormality of the fingertips (HP:0001211)2.10475133
86Insomnia (HP:0100785)2.09622673
87Hemiparesis (HP:0001269)2.09273967
88Abnormality of saccadic eye movements (HP:0000570)2.07095273
89Lower limb amyotrophy (HP:0007210)2.06829085
90Stereotypic behavior (HP:0000733)2.06594413
91Posterior subcapsular cataract (HP:0007787)2.04196544
92Retinal atrophy (HP:0001105)2.00416183
93Spastic gait (HP:0002064)2.00084794
94Lower limb muscle weakness (HP:0007340)1.99829360
95Abnormality of macrophages (HP:0004311)1.97855294
96Spinal canal stenosis (HP:0003416)1.97451562
97Bundle branch block (HP:0011710)1.94741942
98Abnormal eating behavior (HP:0100738)1.92760661
99Akinesia (HP:0002304)1.91299050
100Decreased circulating renin level (HP:0003351)1.89988583
101Abnormality of calcium-phosphate metabolism (HP:0100530)1.89747079
102Chorioretinal atrophy (HP:0000533)1.88557360
103Abnormality of liposaccharide metabolism (HP:0010968)1.88407010
104Abnormality of glycosphingolipid metabolism (HP:0004343)1.88407010
105Abnormality of glycolipid metabolism (HP:0010969)1.88407010
106Ventricular fibrillation (HP:0001663)1.88274916
107Ocular albinism (HP:0001107)1.87655343
108Progressive visual loss (HP:0000529)1.87467228
109Intention tremor (HP:0002080)1.86556858
110Hyperacusis (HP:0010780)1.85266722
111Urinary urgency (HP:0000012)1.83938217
112Purpura (HP:0000979)1.83797680
113Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.83741543
114Decreased motor nerve conduction velocity (HP:0003431)1.83517323
115Menstrual irregularities (HP:0000858)1.83097372
116Abnormality of the corticospinal tract (HP:0002492)1.82072651
117Lower limb asymmetry (HP:0100559)1.81982302
118Pointed chin (HP:0000307)1.79574365
119Mucopolysacchariduria (HP:0008155)1.79482151
120Urinary glycosaminoglycan excretion (HP:0003541)1.79482151
121Bowel incontinence (HP:0002607)1.79416084
122Hyperventilation (HP:0002883)1.79009420
123Amblyopia (HP:0000646)1.78737238
124Growth hormone excess (HP:0000845)1.77341469
125Recurrent bacterial skin infections (HP:0005406)1.76124725
126Abnormal delayed hypersensitivity skin test (HP:0002963)1.76043097
127Retinitis pigmentosa (HP:0000510)1.75763759
128Cellulitis (HP:0100658)1.75546330
129Increased neuronal autofluorescent lipopigment (HP:0002074)1.74805727
130Inappropriate behavior (HP:0000719)1.74603037
131Torticollis (HP:0000473)1.74534362
132J-shaped sella turcica (HP:0002680)1.74384569
133Epistaxis (HP:0000421)1.73458845
134Distal lower limb amyotrophy (HP:0008944)1.73289861
135Loss of speech (HP:0002371)1.73124516
136Postural tremor (HP:0002174)1.72984269
137Absent speech (HP:0001344)1.72853244
138Abnormality of mucopolysaccharide metabolism (HP:0011020)1.72831527
139Abnormality of polysaccharide metabolism (HP:0011012)1.72831527
140Abnormality of glycosaminoglycan metabolism (HP:0004371)1.72831527
141Spontaneous hematomas (HP:0007420)1.72555739
142Abnormality of the periventricular white matter (HP:0002518)1.72017555
143Neuronal loss in central nervous system (HP:0002529)1.71775310
144Recurrent abscess formation (HP:0002722)1.71750565
145Onion bulb formation (HP:0003383)1.71545292
146Increased cerebral lipofuscin (HP:0011813)1.71135484
147Gait imbalance (HP:0002141)1.70909834
148Status epilepticus (HP:0002133)1.70271011
149Impaired vibratory sensation (HP:0002495)1.68281796
150Choroideremia (HP:0001139)1.68070996
151Hypercortisolism (HP:0001578)1.67827778
152Psychosis (HP:0000709)1.67022375
153Clonus (HP:0002169)1.65289729

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.95989331
2MAP3K93.28845929
3MAP3K42.52648761
4MARK12.49166933
5EPHA42.44766684
6INSRR2.38138297
7SIK22.35003717
8TRIB32.32404666
9DAPK22.20970459
10CAMKK12.16322211
11PRKD32.12866535
12MINK12.01748873
13MAP2K71.98623303
14PAK61.94180045
15CDK121.78755314
16CAMKK21.77613083
17RIPK41.74998021
18PRKCH1.69928882
19NTRK21.69301108
20KSR21.69062306
21FES1.67606954
22TAOK31.65542602
23ICK1.63227234
24MAP3K131.60800359
25STK381.58798249
26HIPK21.57216114
27MAP3K21.53970881
28CAMK1G1.46422315
29SGK31.45852536
30SGK21.43759449
31NTRK11.42512017
32ERN11.42003974
33CDK51.40938242
34MAP2K41.36175095
35MAP3K121.32848993
36TNK21.26531290
37DAPK11.25629145
38RIPK11.24217327
39TAOK11.21462789
40PRPF4B1.19890095
41SGK4941.19272897
42SGK2231.19272897
43EEF2K1.18256343
44CAMK11.10798987
45ZAP701.10698555
46MAP3K11.10628478
47MARK21.07326207
48RET1.07204903
49PRKD21.06805185
50MAP2K31.05148680
51SIK11.02472512
52UHMK11.01970965
53GRK51.01193067
54ALK1.01132895
55ARAF0.95147979
56CDC42BPA0.95006746
57STK110.94871990
58TNIK0.94598975
59KSR10.93141357
60SIK30.92670151
61NEK60.92245185
62PRKCG0.91347317
63PNCK0.90215598
64MAP3K70.90175916
65JAK10.87289355
66GRK10.87244506
67MAP3K110.84634541
68FGFR40.83859396
69SCYL20.82879636
70BLK0.82788361
71TYK20.79568418
72PDK10.78949600
73MAPK130.78388636
74SGK10.76897118
75CAMK40.75824106
76PKN20.75042745
77IRAK20.75040679
78PINK10.73423405
79TYRO30.71494100
80DYRK1A0.69452267
81MAP4K10.67565787
82MAP3K60.66456640
83BTK0.66407277
84SYK0.65771577
85CAMK1D0.65612671
86CDK190.64736267
87SMG10.64505298
88MAP3K140.61403270
89PLK20.60610944
90WNK10.60025506
91FGFR30.58925141
92ITK0.58293891
93TXK0.57706510
94RPS6KA20.56477737
95JAK20.56136715
96BMX0.56062070
97BMPR20.55699395
98MAPK100.55270822
99CAMK2A0.55023460
100PASK0.54025479
101RPS6KA30.53820416
102MAPK70.53704390
103MTOR0.53313062
104PDPK10.53059072
105CSK0.52897566
106CASK0.52821498
107IRAK30.50692034
108MAPK110.50615886
109TTN0.50321103
110FYN0.50117489
111TBK10.49956331
112TESK10.49805938
113LATS20.48961637
114EPHB10.48877533
115GRK60.47393175
116CAMK2B0.46919092
117HCK0.46847915
118CSNK1G20.46129477
119PRKCB0.44936630
120PAK30.42537943
121BRD40.41839234
122PHKG20.41439333
123PHKG10.41439333
124RAF10.39892224
125CDK180.37909916
126MAPK120.37737691
127CDK150.37676675
128PRKCZ0.37575610
129PRKAA10.37019295
130MAPK80.34308377
131MAPK150.34137770

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.44015279
2Synaptic vesicle cycle_Homo sapiens_hsa047213.05825063
3Nicotine addiction_Homo sapiens_hsa050332.73816040
4Olfactory transduction_Homo sapiens_hsa047402.63668307
5Insulin secretion_Homo sapiens_hsa049112.44037789
6GABAergic synapse_Homo sapiens_hsa047272.37960027
7Circadian entrainment_Homo sapiens_hsa047132.36991712
8Morphine addiction_Homo sapiens_hsa050322.30581469
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22866205
10Long-term potentiation_Homo sapiens_hsa047202.19202656
11Glutamatergic synapse_Homo sapiens_hsa047242.11445742
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.05378794
13Amphetamine addiction_Homo sapiens_hsa050311.96618132
14Cholinergic synapse_Homo sapiens_hsa047251.90417976
15Type II diabetes mellitus_Homo sapiens_hsa049301.90059494
16Dopaminergic synapse_Homo sapiens_hsa047281.86768357
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84354514
18Salivary secretion_Homo sapiens_hsa049701.79114916
19Taste transduction_Homo sapiens_hsa047421.63471523
20Gastric acid secretion_Homo sapiens_hsa049711.57453073
21Cocaine addiction_Homo sapiens_hsa050301.49616016
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49586034
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48361991
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.46750782
25Renin secretion_Homo sapiens_hsa049241.45333375
26Oxytocin signaling pathway_Homo sapiens_hsa049211.40175458
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39118161
28Serotonergic synapse_Homo sapiens_hsa047261.37904305
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.32309061
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29338330
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.27629030
32Long-term depression_Homo sapiens_hsa047301.26461562
33Acute myeloid leukemia_Homo sapiens_hsa052211.23878290
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23148600
35Calcium signaling pathway_Homo sapiens_hsa040201.20893588
36Other glycan degradation_Homo sapiens_hsa005111.20662031
37GnRH signaling pathway_Homo sapiens_hsa049121.20633218
38Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.19496183
39cAMP signaling pathway_Homo sapiens_hsa040241.14623578
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14245788
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09440228
42Estrogen signaling pathway_Homo sapiens_hsa049151.05410231
43Type I diabetes mellitus_Homo sapiens_hsa049401.03266527
44Glioma_Homo sapiens_hsa052141.02160978
45Circadian rhythm_Homo sapiens_hsa047101.00616163
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98054965
47Pancreatic secretion_Homo sapiens_hsa049720.97487325
48Gap junction_Homo sapiens_hsa045400.95088119
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94708823
50mTOR signaling pathway_Homo sapiens_hsa041500.90738357
51Collecting duct acid secretion_Homo sapiens_hsa049660.89396704
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.88669524
53Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88251885
54ErbB signaling pathway_Homo sapiens_hsa040120.87619047
55Inositol phosphate metabolism_Homo sapiens_hsa005620.83944791
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80783419
57Tuberculosis_Homo sapiens_hsa051520.80096428
58MAPK signaling pathway_Homo sapiens_hsa040100.79312525
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79036855
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.79031690
61Thyroid hormone synthesis_Homo sapiens_hsa049180.78531922
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.77638860
63Dorso-ventral axis formation_Homo sapiens_hsa043200.77302448
64Chemokine signaling pathway_Homo sapiens_hsa040620.77032477
65Prolactin signaling pathway_Homo sapiens_hsa049170.75511813
66Notch signaling pathway_Homo sapiens_hsa043300.73823194
67Leishmaniasis_Homo sapiens_hsa051400.73177914
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72733105
69Pancreatic cancer_Homo sapiens_hsa052120.71912162
70Lysosome_Homo sapiens_hsa041420.71275860
71Vibrio cholerae infection_Homo sapiens_hsa051100.71186591
72Endometrial cancer_Homo sapiens_hsa052130.70368090
73Choline metabolism in cancer_Homo sapiens_hsa052310.69570935
74T cell receptor signaling pathway_Homo sapiens_hsa046600.69316684
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68950120
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.68902246
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66892170
78Melanogenesis_Homo sapiens_hsa049160.66756491
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66584832
80Glucagon signaling pathway_Homo sapiens_hsa049220.65186361
81Non-small cell lung cancer_Homo sapiens_hsa052230.64983289
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.64849317
83VEGF signaling pathway_Homo sapiens_hsa043700.62719296
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61277824
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60242810
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.59036283
87Endocytosis_Homo sapiens_hsa041440.58581572
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57425539
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.55353935
90HIF-1 signaling pathway_Homo sapiens_hsa040660.55102102
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54038383
92Hepatitis B_Homo sapiens_hsa051610.53983817
93AMPK signaling pathway_Homo sapiens_hsa041520.53495868
94Salmonella infection_Homo sapiens_hsa051320.52889018
95TNF signaling pathway_Homo sapiens_hsa046680.52297821
96B cell receptor signaling pathway_Homo sapiens_hsa046620.52269019
97Insulin signaling pathway_Homo sapiens_hsa049100.51824666
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51636836
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51266411
100Dilated cardiomyopathy_Homo sapiens_hsa054140.50857255
101Osteoclast differentiation_Homo sapiens_hsa043800.49316643
102Axon guidance_Homo sapiens_hsa043600.48179463
103Ras signaling pathway_Homo sapiens_hsa040140.48172395
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47890481
105Oocyte meiosis_Homo sapiens_hsa041140.47454906
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47331572
107Colorectal cancer_Homo sapiens_hsa052100.46677823
108Platelet activation_Homo sapiens_hsa046110.45074753
109ABC transporters_Homo sapiens_hsa020100.43557365
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.42487709
111Insulin resistance_Homo sapiens_hsa049310.42393534
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42086198
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42032825
114Rap1 signaling pathway_Homo sapiens_hsa040150.40744466
115Renal cell carcinoma_Homo sapiens_hsa052110.39873944
116Nitrogen metabolism_Homo sapiens_hsa009100.39761318
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38638164
118Alcoholism_Homo sapiens_hsa050340.38556934
119Chronic myeloid leukemia_Homo sapiens_hsa052200.37624418
120Primary immunodeficiency_Homo sapiens_hsa053400.36094312
121Prion diseases_Homo sapiens_hsa050200.34726475

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