MAEA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)4.19385271
2formation of translation preinitiation complex (GO:0001731)4.18137715
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.09495743
4negative regulation of cell killing (GO:0031342)4.09495743
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.97002079
6positive regulation by organism of defense response of other organism involved in symbiotic interact3.97002079
7modulation by symbiont of host immune response (GO:0052553)3.97002079
8positive regulation by symbiont of host defense response (GO:0052509)3.97002079
9modulation by symbiont of host defense response (GO:0052031)3.97002079
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.97002079
11positive regulation of Cdc42 GTPase activity (GO:0043089)3.90956311
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.86702502
13DNA unwinding involved in DNA replication (GO:0006268)3.85305642
14pyrimidine-containing compound salvage (GO:0008655)3.73656311
15pyrimidine nucleoside salvage (GO:0043097)3.73656311
16mitotic nuclear envelope disassembly (GO:0007077)3.72085220
17antigen processing and presentation of endogenous antigen (GO:0019883)3.68548958
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.61392467
19protein localization to chromosome, centromeric region (GO:0071459)3.58645204
20GDP-mannose metabolic process (GO:0019673)3.58533919
21IMP biosynthetic process (GO:0006188)3.58404464
22response to peptidoglycan (GO:0032494)3.57925259
23NIK/NF-kappaB signaling (GO:0038061)3.57045252
24ribosomal small subunit assembly (GO:0000028)3.55921907
25neutrophil activation involved in immune response (GO:0002283)3.54793451
26nuclear envelope disassembly (GO:0051081)3.54376362
27membrane disassembly (GO:0030397)3.54376362
28COPI coating of Golgi vesicle (GO:0048205)3.52170649
29Golgi transport vesicle coating (GO:0048200)3.52170649
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.49598392
31negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.42788423
32IMP metabolic process (GO:0046040)3.31632753
33DNA strand elongation involved in DNA replication (GO:0006271)3.30308105
34DNA strand elongation (GO:0022616)3.24762494
35protein localization to endosome (GO:0036010)3.22286319
36mannose metabolic process (GO:0006013)3.20919341
37barbed-end actin filament capping (GO:0051016)3.20044174
38DNA replication-dependent nucleosome assembly (GO:0006335)3.19494669
39DNA replication-dependent nucleosome organization (GO:0034723)3.19494669
40positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.19272113
41negative regulation of erythrocyte differentiation (GO:0045647)3.18713923
42nucleobase biosynthetic process (GO:0046112)3.18706216
43protein maturation by protein folding (GO:0022417)3.18664474
44regulation of superoxide anion generation (GO:0032928)3.18399620
45mitotic chromosome condensation (GO:0007076)3.13065462
46DNA replication initiation (GO:0006270)3.13056605
47regulation of mast cell degranulation (GO:0043304)3.12343444
48folic acid-containing compound biosynthetic process (GO:0009396)3.10930838
49detection of other organism (GO:0098543)3.08592717
50leukocyte aggregation (GO:0070486)3.06464842
51detection of bacterium (GO:0016045)3.05706450
52retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.00727229
53postreplication repair (GO:0006301)2.99721684
54nuclear pore organization (GO:0006999)2.99101446
55regulation of leukocyte degranulation (GO:0043300)2.96467601
56regulation of protein heterodimerization activity (GO:0043497)2.95524313
57regulation of translational termination (GO:0006449)2.94007657
58regulation of interferon-beta biosynthetic process (GO:0045357)2.92095907
59regulation of mammary gland epithelial cell proliferation (GO:0033599)2.91818495
60purine nucleobase biosynthetic process (GO:0009113)2.89865103
61respiratory burst (GO:0045730)2.88637648
62nuclear pore complex assembly (GO:0051292)2.88138370
63regulation of gene silencing by RNA (GO:0060966)2.88114260
64regulation of posttranscriptional gene silencing (GO:0060147)2.88114260
65regulation of gene silencing by miRNA (GO:0060964)2.88114260
66regulation of spindle organization (GO:0090224)2.87126065
67translesion synthesis (GO:0019985)2.86970932
68regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.85111979
69nuclear envelope organization (GO:0006998)2.84700744
70dosage compensation (GO:0007549)2.84134782
71regulation of myeloid leukocyte mediated immunity (GO:0002886)2.84019900
72morphogenesis of an endothelium (GO:0003159)2.83850213
73endothelial tube morphogenesis (GO:0061154)2.83850213
74intracellular estrogen receptor signaling pathway (GO:0030520)2.81814133
75mitotic metaphase plate congression (GO:0007080)2.81676684
76regulation of hippo signaling (GO:0035330)2.81234683
77macrophage activation involved in immune response (GO:0002281)2.80975757
78regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.79074993
79histone H2A acetylation (GO:0043968)2.77401440
80regulation of defense response to virus by virus (GO:0050690)2.76319571
81mitotic sister chromatid segregation (GO:0000070)2.75944185
82negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.75607015
83positive regulation of gamma-delta T cell activation (GO:0046645)2.74222961
84apoptotic process involved in morphogenesis (GO:0060561)2.73699198
85peptidyl-arginine omega-N-methylation (GO:0035247)2.71014951
86negative regulation of interleukin-12 production (GO:0032695)2.70716762
87positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.69887216
88telomere maintenance via semi-conservative replication (GO:0032201)2.66170642
89negative regulation of phagocytosis (GO:0050765)2.64642140
90nodal signaling pathway (GO:0038092)2.64453267
91paraxial mesoderm development (GO:0048339)2.64417552
92deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.64285673
93DNA replication-independent nucleosome organization (GO:0034724)2.63840463
94DNA replication-independent nucleosome assembly (GO:0006336)2.63840463
95protein localization to chromosome (GO:0034502)2.62866438
96sister chromatid segregation (GO:0000819)2.62492961
97amino sugar catabolic process (GO:0046348)2.62423809
98neutrophil activation (GO:0042119)2.59980326
99regulation of SMAD protein import into nucleus (GO:0060390)2.59498649
100maturation of SSU-rRNA (GO:0030490)2.59498646
101pentose-phosphate shunt (GO:0006098)2.59467250
1023-UTR-mediated mRNA stabilization (GO:0070935)2.58042853
103regulation of mast cell activation involved in immune response (GO:0033006)2.57292584
104anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.57173113
105positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.56497450
106heterochromatin organization (GO:0070828)2.56178238
107translational elongation (GO:0006414)2.56111074
108CENP-A containing nucleosome assembly (GO:0034080)2.55644526
109response to muramyl dipeptide (GO:0032495)2.55494361
110regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.53873692
111negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.53527892
112virion assembly (GO:0019068)2.53166955
113epithelial cell-cell adhesion (GO:0090136)2.52341874
114detection of external biotic stimulus (GO:0098581)2.51158845
115regulation of mitotic spindle organization (GO:0060236)2.49941075
116pinocytosis (GO:0006907)2.49317040
117mitotic spindle assembly checkpoint (GO:0007094)2.49240090
118Arp2/3 complex-mediated actin nucleation (GO:0034314)2.48771985
119positive regulation of SMAD protein import into nucleus (GO:0060391)2.48329245
120negative regulation of chromosome segregation (GO:0051985)2.47932472
121translational initiation (GO:0006413)2.47772517
122regulation of chromatin binding (GO:0035561)2.47623874
123regulation of type I interferon-mediated signaling pathway (GO:0060338)2.46971600
124negative regulation of mitotic sister chromatid separation (GO:2000816)2.46722499
125negative regulation of mitotic sister chromatid segregation (GO:0033048)2.46722499
126negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.46722499
127negative regulation of sister chromatid segregation (GO:0033046)2.46722499
128activation of Rac GTPase activity (GO:0032863)2.46497030
129regulation of regulated secretory pathway (GO:1903305)2.46430016
130response to laminar fluid shear stress (GO:0034616)2.46227266
131chromatin remodeling at centromere (GO:0031055)2.45767022
132metaphase plate congression (GO:0051310)2.45481109
133somatic hypermutation of immunoglobulin genes (GO:0016446)2.45214936
134somatic diversification of immune receptors via somatic mutation (GO:0002566)2.45214936
135negative regulation of toll-like receptor signaling pathway (GO:0034122)2.45007849
136positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.44657819
137granulocyte activation (GO:0036230)2.44558607
138proline biosynthetic process (GO:0006561)2.43716952
139epithelial cell differentiation involved in prostate gland development (GO:0060742)2.42398778
140regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.42237998
141negative regulation of RNA splicing (GO:0033119)2.42012960
142regulation of T-helper 2 cell differentiation (GO:0045628)2.41987746
143regulation of sister chromatid cohesion (GO:0007063)2.41819071
144negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.41729657
145establishment of chromosome localization (GO:0051303)2.41502242
146spindle assembly checkpoint (GO:0071173)2.41487383
147spliceosomal snRNP assembly (GO:0000387)2.41186721
148telomere maintenance via recombination (GO:0000722)2.41146714
149antigen processing and presentation via MHC class Ib (GO:0002475)2.40888409
150interferon-gamma secretion (GO:0072643)2.40774817
151chromatin assembly or disassembly (GO:0006333)2.40726589
152DNA duplex unwinding (GO:0032508)2.39469338
153mitotic spindle checkpoint (GO:0071174)2.39456221
154regulation of translational fidelity (GO:0006450)2.37976230
155N-acetylneuraminate metabolic process (GO:0006054)2.37450955
156DNA geometric change (GO:0032392)2.37422885
157spliceosomal tri-snRNP complex assembly (GO:0000244)2.37101455
158ribosome assembly (GO:0042255)2.36530075
159protein retention in ER lumen (GO:0006621)2.36449662
160T cell apoptotic process (GO:0070231)2.36216246
161sequestering of actin monomers (GO:0042989)2.35486456
162negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.35307527
163metallo-sulfur cluster assembly (GO:0031163)2.35083097
164iron-sulfur cluster assembly (GO:0016226)2.35083097
165regulation of chromosome segregation (GO:0051983)2.34731790
166lipopolysaccharide-mediated signaling pathway (GO:0031663)2.34295634
167regulation of necrotic cell death (GO:0010939)2.33370750
168negative regulation of ligase activity (GO:0051352)2.32856539
169negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.32856539
170mitotic recombination (GO:0006312)2.32791053
171nucleoside salvage (GO:0043174)2.32542670
172negative regulation of cell size (GO:0045792)2.32453880
173translational termination (GO:0006415)2.31676305
174histone-serine phosphorylation (GO:0035404)2.30751239
175stress fiber assembly (GO:0043149)2.29907286
176negative regulation of leukocyte mediated immunity (GO:0002704)2.27328828
177maternal placenta development (GO:0001893)2.24416209
178positive regulation of leukocyte degranulation (GO:0043302)2.23054184
179modulation by virus of host process (GO:0019054)2.22783867
180modulation by symbiont of host cellular process (GO:0044068)2.22211010
181NADPH regeneration (GO:0006740)2.22076398
182response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.21487522
183response to host (GO:0075136)2.21487522
184response to host defenses (GO:0052200)2.21487522
185response to host immune response (GO:0052572)2.20880097
186response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.20880097
187negative regulation of innate immune response (GO:0045824)2.20460849
188positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.19183225
189cellular response to virus (GO:0098586)2.17908256
190immunoglobulin mediated immune response (GO:0016064)2.17727090
191pantothenate metabolic process (GO:0015939)2.16742934
192detection of molecule of bacterial origin (GO:0032490)2.16412297
193chaperone mediated protein folding requiring cofactor (GO:0051085)2.16322352

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.70291228
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.04716893
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.32418546
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.21854196
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.00899702
6MYC_22102868_ChIP-Seq_BL_Human2.48125837
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39789382
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28187091
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.27298158
10LXR_22292898_ChIP-Seq_THP-1_Human2.23169816
11NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18129762
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.17109920
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11873803
14XRN2_22483619_ChIP-Seq_HELA_Human2.08979540
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03971175
16* ETS1_20019798_ChIP-Seq_JURKAT_Human1.94752299
17EST1_17652178_ChIP-ChIP_JURKAT_Human1.93577670
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92939615
19RACK7_27058665_Chip-Seq_MCF-7_Human1.87010025
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.86376798
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.85261437
22CIITA_25753668_ChIP-Seq_RAJI_Human1.84272242
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81432356
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80777848
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79484370
26* AR_21909140_ChIP-Seq_LNCAP_Human1.76475794
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75843877
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75073978
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.74359473
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.73048897
31ZFX_18555785_ChIP-Seq_MESCs_Mouse1.71724048
32VDR_21846776_ChIP-Seq_THP-1_Human1.69670932
33SRY_22984422_ChIP-ChIP_TESTIS_Rat1.69486278
34GABP_19822575_ChIP-Seq_HepG2_Human1.67936203
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63317950
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63012614
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.61204175
38* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60923350
39VDR_24763502_ChIP-Seq_THP-1_Human1.60350658
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59273830
41KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.56474117
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53773912
43DCP1A_22483619_ChIP-Seq_HELA_Human1.53753013
44KDM2B_26808549_Chip-Seq_DND41_Human1.53426359
45TET1_21451524_ChIP-Seq_MESCs_Mouse1.52803355
46P68_20966046_ChIP-Seq_HELA_Human1.52609716
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.50336699
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49497124
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46519311
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46042281
51MAF_26560356_Chip-Seq_TH2_Human1.45362219
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44768866
53MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.44676923
54* VDR_23849224_ChIP-Seq_CD4+_Human1.43281677
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42328231
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41633911
57FOXP3_21729870_ChIP-Seq_TREG_Human1.41235659
58* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40547627
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40330101
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39956515
61* RUNX1_22412390_ChIP-Seq_EML_Mouse1.39953431
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39006441
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38344098
64TFEB_21752829_ChIP-Seq_HELA_Human1.37859623
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36490692
66TTF2_22483619_ChIP-Seq_HELA_Human1.36343577
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.35533162
68ATF3_27146783_Chip-Seq_COLON_Human1.35210917
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34132689
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.31892912
71CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30927883
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.30531485
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29600580
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29243145
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28839873
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28806828
77* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28092594
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26225080
79KDM5A_27292631_Chip-Seq_BREAST_Human1.25109367
80* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24923991
81CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23855807
82BCL6_27268052_Chip-Seq_Bcells_Human1.23487111
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23444280
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23368724
85BCOR_27268052_Chip-Seq_Bcells_Human1.22710785
86CLOCK_20551151_ChIP-Seq_293T_Human1.21829985
87* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20432277
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19768878
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19762673
90* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18842953
91STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18839875
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18280338
93NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.17586133
94RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17395013
95NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17224531
96PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16471346
97* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15986742
98* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13127088
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12670421
100SMC4_20622854_ChIP-Seq_HELA_Human1.12600155
101ZNF263_19887448_ChIP-Seq_K562_Human1.11930484
102YY1_21170310_ChIP-Seq_MESCs_Mouse1.11850705
103* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11745231
104SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11194747
105TP63_17297297_ChIP-ChIP_HaCaT_Human1.10312676
106KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09969964
107KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09943243
108TCF7_22412390_ChIP-Seq_EML_Mouse1.09689219
109SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09177766
110STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08249100
111UTX_26944678_Chip-Seq_JUKART_Human1.08098564
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07724333
113* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07675866
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06768571
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06438344
116NCOR1_26117541_ChIP-Seq_K562_Human1.06169251
117MAF_26560356_Chip-Seq_TH1_Human1.06122366
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05752882
119SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04993677
120SRF_21415370_ChIP-Seq_HL-1_Mouse1.04757653
121CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04631469
122EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03708895
123IRF8_21731497_ChIP-ChIP_J774_Mouse1.03032988
124CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02954833
125HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02654398
126KDM2B_26808549_Chip-Seq_K562_Human1.02547511
127* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02406626
128SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02314482
129RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01995165
130ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01304493
131E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01128682
132ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01087322
133* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99049366
134ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98679252
135ELK1_19687146_ChIP-ChIP_HELA_Human0.98364095
136RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98140288
137ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97894379
138SPI1_23547873_ChIP-Seq_NB4_Human0.97702546
139NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97178618
140MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96997594
141GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96565043
142NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94781971
143KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93513205
144TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93510312

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008260_abnormal_autophagy4.10611478
2MP0003303_peritoneal_inflammation3.23077214
3MP0003436_decreased_susceptibility_to3.17064405
4MP0003693_abnormal_embryo_hatching2.92621596
5MP0005451_abnormal_body_composition2.90379540
6MP0003705_abnormal_hypodermis_morpholog2.87330734
7MP0010352_gastrointestinal_tract_polyps2.85585725
8MP0003191_abnormal_cellular_cholesterol2.81700829
9MP0003077_abnormal_cell_cycle2.60385556
10MP0004957_abnormal_blastocyst_morpholog2.56997037
11MP0010094_abnormal_chromosome_stability2.48970031
12MP0003123_paternal_imprinting2.47298820
13MP0003111_abnormal_nucleus_morphology2.41246209
14MP0000678_abnormal_parathyroid_gland2.32580683
15MP0008007_abnormal_cellular_replicative2.28135091
16MP0008438_abnormal_cutaneous_collagen2.20084439
17MP0000537_abnormal_urethra_morphology2.14232656
18MP0006054_spinal_hemorrhage2.06903216
19MP0003724_increased_susceptibility_to2.06625230
20MP0002419_abnormal_innate_immunity1.95931762
21MP0006082_CNS_inflammation1.91275012
22MP0003566_abnormal_cell_adhesion1.90447031
23MP0009840_abnormal_foam_cell1.89814036
24MP0001730_embryonic_growth_arrest1.86966840
25MP0002796_impaired_skin_barrier1.85141185
26MP0005025_abnormal_response_to1.82880392
27MP0004808_abnormal_hematopoietic_stem1.81839613
28MP0004947_skin_inflammation1.81658633
29MP0002396_abnormal_hematopoietic_system1.81555030
30MP0004858_abnormal_nervous_system1.79318700
31MP0004084_abnormal_cardiac_muscle1.77216794
32MP0003806_abnormal_nucleotide_metabolis1.76804106
33MP0003279_aneurysm1.73689521
34MP0003172_abnormal_lysosome_physiology1.72228563
35MP0000350_abnormal_cell_proliferation1.69435957
36MP0003763_abnormal_thymus_physiology1.64672514
37MP0005501_abnormal_skin_physiology1.61452454
38MP0001849_ear_inflammation1.61104111
39MP0010030_abnormal_orbit_morphology1.59938083
40MP0001790_abnormal_immune_system1.55760255
41MP0005387_immune_system_phenotype1.55760255
42MP0008932_abnormal_embryonic_tissue1.55416806
43MP0003453_abnormal_keratinocyte_physiol1.54037112
44MP0003567_abnormal_fetal_cardiomyocyte1.53978724
45MP0005076_abnormal_cell_differentiation1.53900286
46MP0005023_abnormal_wound_healing1.53656476
47MP0000490_abnormal_crypts_of1.50613220
48MP0001819_abnormal_immune_cell1.50520194
49MP0002420_abnormal_adaptive_immunity1.50143748
50MP0002452_abnormal_antigen_presenting1.49692794
51MP0001697_abnormal_embryo_size1.48982047
52MP0005000_abnormal_immune_tolerance1.48200663
53MP0001533_abnormal_skeleton_physiology1.46713956
54MP0000733_abnormal_muscle_development1.46197637
55MP0008058_abnormal_DNA_repair1.45320444
56MP0002132_abnormal_respiratory_system1.43177404
57MP0002723_abnormal_immune_serum1.42303332
58MP0010307_abnormal_tumor_latency1.40990063
59MP0009785_altered_susceptibility_to1.39490164
60MP0001800_abnormal_humoral_immune1.38556847
61MP0000858_altered_metastatic_potential1.38405357
62MP0010155_abnormal_intestine_physiology1.36068888
63MP0001835_abnormal_antigen_presentation1.34462286
64MP0002080_prenatal_lethality1.34168341
65MP0005464_abnormal_platelet_physiology1.34091909
66MP0003984_embryonic_growth_retardation1.33302416
67MP0001672_abnormal_embryogenesis/_devel1.30648061
68MP0005380_embryogenesis_phenotype1.30648061
69MP0003121_genomic_imprinting1.30235940
70MP0002088_abnormal_embryonic_growth/wei1.30008415
71MP0005671_abnormal_response_to1.29601962
72MP0002877_abnormal_melanocyte_morpholog1.28807460
73MP0002653_abnormal_ependyma_morphology1.26852678
74MP0000534_abnormal_ureter_morphology1.26187588
75MP0003300_gastrointestinal_ulcer1.26132260
76MP0005275_abnormal_skin_tensile1.25862213
77MP0002148_abnormal_hypersensitivity_rea1.24999957
78MP0004233_abnormal_muscle_weight1.24421671
79MP0009053_abnormal_anal_canal1.24033977
80* MP0000716_abnormal_immune_system1.20930913
81MP0002085_abnormal_embryonic_tissue1.19990448
82MP0004272_abnormal_basement_membrane1.19529166
83MP0002086_abnormal_extraembryonic_tissu1.19001474
84MP0009278_abnormal_bone_marrow1.18306575
85MP0005623_abnormal_meninges_morphology1.18282489
86MP0000750_abnormal_muscle_regeneration1.17552649
87MP0010630_abnormal_cardiac_muscle1.16445849
88MP0001958_emphysema1.16435229
89MP0002019_abnormal_tumor_incidence1.15119944
90MP0004381_abnormal_hair_follicle1.14592086
91* MP0002429_abnormal_blood_cell1.14391515
92MP0005397_hematopoietic_system_phenotyp1.14158388
93MP0001545_abnormal_hematopoietic_system1.14158388
94* MP0004197_abnormal_fetal_growth/weight/1.13657624
95MP0004087_abnormal_muscle_fiber1.13489837
96MP0001915_intracranial_hemorrhage1.11729721
97MP0000358_abnormal_cell_content/1.10367778
98MP0000313_abnormal_cell_death1.10119101
99MP0002405_respiratory_system_inflammati1.09939086
100MP0002084_abnormal_developmental_patter1.09780882
101MP0004185_abnormal_adipocyte_glucose1.06123520
102MP0003221_abnormal_cardiomyocyte_apopto1.05695395
103MP0001845_abnormal_inflammatory_respons1.02811138
104MP0002269_muscular_atrophy1.01503937
105MP0009333_abnormal_splenocyte_physiolog1.01300288
106MP0005257_abnormal_intraocular_pressure1.00446423
107MP0000689_abnormal_spleen_morphology1.00413704
108MP0001216_abnormal_epidermal_layer0.98463350
109MP0008469_abnormal_protein_level0.97975808
110MP0003942_abnormal_urinary_system0.97678946
111MP0000751_myopathy0.97627933
112MP0001663_abnormal_digestive_system0.96672768
113MP0000604_amyloidosis0.94702943
114MP0000685_abnormal_immune_system0.94548666
115MP0004133_heterotaxia0.92324640
116MP0002060_abnormal_skin_morphology0.92002043
117MP0001853_heart_inflammation0.91799036
118MP0002998_abnormal_bone_remodeling0.91527566
119MP0004510_myositis0.90674847
120MP0003329_amyloid_beta_deposits0.89824390
121MP0010234_abnormal_vibrissa_follicle0.89461624
122MP0000467_abnormal_esophagus_morphology0.88300226
123MP0001544_abnormal_cardiovascular_syste0.88218040
124MP0005385_cardiovascular_system_phenoty0.88218040
125MP0003183_abnormal_peptide_metabolism0.87095884
126MP0003646_muscle_fatigue0.86863844
127MP0003115_abnormal_respiratory_system0.86303551
128MP0003866_abnormal_defecation0.86144640
129MP0001348_abnormal_lacrimal_gland0.85751346
130MP0000266_abnormal_heart_morphology0.84861417
131MP0002254_reproductive_system_inflammat0.84679023
132MP0003091_abnormal_cell_migration0.84353104
133MP0000749_muscle_degeneration0.84255857
134MP0002925_abnormal_cardiovascular_devel0.83769721
135MP0006138_congestive_heart_failure0.83586000
136MP0003075_altered_response_to0.83189551
137MP0002398_abnormal_bone_marrow0.83027713
138MP0005360_urolithiasis0.82992030
139MP0002089_abnormal_postnatal_growth/wei0.82835970
140MP0005390_skeleton_phenotype0.80301187
141MP0000465_gastrointestinal_hemorrhage0.79797598
142MP0005503_abnormal_tendon_morphology0.79650001
143MP0005384_cellular_phenotype0.79539273
144MP0000681_abnormal_thyroid_gland0.79005568
145MP0003283_abnormal_digestive_organ0.78795772
146MP0000759_abnormal_skeletal_muscle0.78637868
147MP0003878_abnormal_ear_physiology0.77956004
148MP0005377_hearing/vestibular/ear_phenot0.77956004
149MP0008057_abnormal_DNA_replication0.77596372
150MP0005621_abnormal_cell_physiology0.77454458
151MP0000343_altered_response_to0.77287100
152MP0002249_abnormal_larynx_morphology0.75797070
153MP0000767_abnormal_smooth_muscle0.75272060
154MP0001873_stomach_inflammation0.74319326
155MP0000703_abnormal_thymus_morphology0.74280890
156MP0002722_abnormal_immune_system0.73884921
157MP0005058_abnormal_lysosome_morphology0.73699860
158MP0000477_abnormal_intestine_morphology0.73253847
159MP0004264_abnormal_extraembryonic_tissu0.72981649
160MP0003119_abnormal_digestive_system0.70499092
161MP0001175_abnormal_lung_morphology0.69786224
162MP0002128_abnormal_blood_circulation0.69381845

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.52901980
2Eczematoid dermatitis (HP:0000976)4.01058798
3Selective tooth agenesis (HP:0001592)3.92309515
4Recurrent abscess formation (HP:0002722)3.44434937
5Abnormality of macrophages (HP:0004311)3.42328573
6Recurrent bacterial skin infections (HP:0005406)3.37454308
7Ankle contracture (HP:0006466)3.14528953
8Abnormality of the anterior horn cell (HP:0006802)2.97660679
9Degeneration of anterior horn cells (HP:0002398)2.97660679
10Abnormality of the calcaneus (HP:0008364)2.94958693
11Cellulitis (HP:0100658)2.89868367
12Colon cancer (HP:0003003)2.74412196
13Cerebral aneurysm (HP:0004944)2.69085912
14Aplastic anemia (HP:0001915)2.63680253
15Cervical subluxation (HP:0003308)2.62807281
16Hyperacusis (HP:0010780)2.62802953
17Wrist flexion contracture (HP:0001239)2.59794411
18Abnormality of the distal phalanges of the toes (HP:0010182)2.57552185
19Increased IgE level (HP:0003212)2.56499117
20Myositis (HP:0100614)2.56316847
21Progressive muscle weakness (HP:0003323)2.54480627
22Shallow orbits (HP:0000586)2.53079299
23Abnormality of liposaccharide metabolism (HP:0010968)2.52153621
24Abnormality of glycosphingolipid metabolism (HP:0004343)2.52153621
25Abnormality of glycolipid metabolism (HP:0010969)2.52153621
26Cutaneous melanoma (HP:0012056)2.52028726
27Increased cerebral lipofuscin (HP:0011813)2.51368500
28Pustule (HP:0200039)2.50462031
29Calcaneovalgus deformity (HP:0001848)2.49391629
30Premature rupture of membranes (HP:0001788)2.48076954
31Distal lower limb amyotrophy (HP:0008944)2.46530452
32Loss of speech (HP:0002371)2.45761430
33Mediastinal lymphadenopathy (HP:0100721)2.45359536
34Rough bone trabeculation (HP:0100670)2.42393733
35Renal duplication (HP:0000075)2.39738523
36Trismus (HP:0000211)2.39334834
37Long palpebral fissure (HP:0000637)2.38932328
38Slow saccadic eye movements (HP:0000514)2.38799559
39Obstructive lung disease (HP:0006536)2.37993625
40Chronic obstructive pulmonary disease (HP:0006510)2.37993625
41Testicular atrophy (HP:0000029)2.36795279
42Bowel diverticulosis (HP:0005222)2.34561721
43Multiple enchondromatosis (HP:0005701)2.34504816
44Short 4th metacarpal (HP:0010044)2.33472871
45Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.33472871
46Exercise-induced muscle cramps (HP:0003710)2.31545505
47Difficulty climbing stairs (HP:0003551)2.31061262
48Aortic aneurysm (HP:0004942)2.30978581
49Increased connective tissue (HP:0009025)2.30384379
50Right ventricular cardiomyopathy (HP:0011663)2.29381032
51Short nail (HP:0001799)2.29377039
52Thin bony cortex (HP:0002753)2.28887436
53Dilatation of the ascending aorta (HP:0005111)2.26573780
54Dysostosis multiplex (HP:0000943)2.24989197
5511 pairs of ribs (HP:0000878)2.23521332
56Increased neuronal autofluorescent lipopigment (HP:0002074)2.21613513
57Thrombocytosis (HP:0001894)2.20548448
58Increased density of long bones (HP:0006392)2.20263528
59Ependymoma (HP:0002888)2.20094007
60Hand muscle atrophy (HP:0009130)2.19628525
61Deformed tarsal bones (HP:0008119)2.18309628
62Distal lower limb muscle weakness (HP:0009053)2.17815209
63Aortic dissection (HP:0002647)2.17768767
64Hepatosplenomegaly (HP:0001433)2.17316249
65Missing ribs (HP:0000921)2.16052920
66Limb-girdle muscle atrophy (HP:0003797)2.15745903
67Slender long bone (HP:0003100)2.15374264
68Obstructive sleep apnea (HP:0002870)2.14300354
69Adenoma sebaceum (HP:0009720)2.13230886
70Angiofibromas (HP:0010615)2.13230886
71Bladder diverticulum (HP:0000015)2.12749036
72Achilles tendon contracture (HP:0001771)2.11922228
73Gingivitis (HP:0000230)2.11297235
74Mesangial abnormality (HP:0001966)2.10934820
75Neuronal loss in central nervous system (HP:0002529)2.10198442
76Premature loss of primary teeth (HP:0006323)2.07435732
77Pelvic girdle muscle weakness (HP:0003749)2.07434545
78Urticaria (HP:0001025)2.07345390
79Distal upper limb amyotrophy (HP:0007149)2.06021209
80Upper limb amyotrophy (HP:0009129)2.06021209
81Ventricular tachycardia (HP:0004756)2.05959415
82Recurrent gram-negative bacterial infections (HP:0005420)2.05647678
83Gastrointestinal inflammation (HP:0004386)2.05325374
84Type 1 muscle fiber predominance (HP:0003803)2.04065178
85Rhabdomyolysis (HP:0003201)2.03940990
86Orchitis (HP:0100796)2.03160485
87Radial bowing (HP:0002986)2.02458104
88Cholecystitis (HP:0001082)2.01751798
89Abnormal gallbladder physiology (HP:0012438)2.01751798
90Microretrognathia (HP:0000308)2.01417708
91Recurrent fungal infections (HP:0002841)2.01282934
92Hypertensive crisis (HP:0100735)2.00209923
93Nail dystrophy (HP:0008404)1.98903094
94Elevated erythrocyte sedimentation rate (HP:0003565)1.97819794
95Enlarged penis (HP:0000040)1.97631685
96Amyloidosis (HP:0011034)1.97323592
97Abnormality of the acetabulum (HP:0003170)1.96967568
98Asymmetric septal hypertrophy (HP:0001670)1.96764966
99Entropion (HP:0000621)1.95338997
100Breech presentation (HP:0001623)1.95161250
101Bicuspid aortic valve (HP:0001647)1.94358804
102Increased serum ferritin (HP:0003281)1.92770589
103Broad face (HP:0000283)1.91422969
104Soft skin (HP:0000977)1.90436185
105Petechiae (HP:0000967)1.90135434
106Vertebral compression fractures (HP:0002953)1.90078025
107Hypertriglyceridemia (HP:0002155)1.89293113
108Atrophy/Degeneration involving motor neurons (HP:0007373)1.89132618
109Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.88659831
110Recurrent viral infections (HP:0004429)1.88482163
111Distal arthrogryposis (HP:0005684)1.88426868
112Stridor (HP:0010307)1.87857928
113Progressive external ophthalmoplegia (HP:0000590)1.87073632
114Ulnar deviation of the wrist (HP:0003049)1.86533956
115Polygenic inheritance (HP:0010982)1.85165820
116Gastrointestinal infarctions (HP:0005244)1.83680361
117Centrally nucleated skeletal muscle fibers (HP:0003687)1.83668883
118Genu recurvatum (HP:0002816)1.83199666
119Abnormality of the 4th metacarpal (HP:0010012)1.82577241
120Recurrent skin infections (HP:0001581)1.81815721
121Microvesicular hepatic steatosis (HP:0001414)1.81663421
122Abnormality of alkaline phosphatase activity (HP:0004379)1.79077717
123Disproportionate tall stature (HP:0001519)1.78761856
124Palpitations (HP:0001962)1.78719028
125Broad palm (HP:0001169)1.78554644
126Generalized amyotrophy (HP:0003700)1.78346362
127Neoplasm of the pancreas (HP:0002894)1.78199171
128Deviation of the thumb (HP:0009603)1.78154424
129Gastrointestinal dysmotility (HP:0002579)1.78072795
130Abnormal trabecular bone morphology (HP:0100671)1.77917612
131Abnormality of polysaccharide metabolism (HP:0011012)1.77585614
132Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77585614
133Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77585614
134Supranuclear gaze palsy (HP:0000605)1.76977422
135Increased nuchal translucency (HP:0010880)1.76923112
136Reduced subcutaneous adipose tissue (HP:0003758)1.75671815
137Intestinal polyp (HP:0005266)1.75419023
138Biconcave vertebral bodies (HP:0004586)1.73414225
139Broad distal phalanx of finger (HP:0009836)1.73191602
140High pitched voice (HP:0001620)1.72497023
141Purpura (HP:0000979)1.72382448
142Easy fatigability (HP:0003388)1.71905959
143Upper motor neuron abnormality (HP:0002127)1.71689592
144Abnormal enzyme/coenzyme activity (HP:0012379)1.71581746
145Inflammation of the large intestine (HP:0002037)1.71357683
146Shoulder girdle muscle weakness (HP:0003547)1.71329813
147Vacuolated lymphocytes (HP:0001922)1.70756499
148Long toe (HP:0010511)1.69700336
149Progressive neurologic deterioration (HP:0002344)1.69200115
150Patellar aplasia (HP:0006443)1.69037296
151Meningitis (HP:0001287)1.68900659
152Fragile nails (HP:0001808)1.68614258
153Bone pain (HP:0002653)1.68353388
154Peritonitis (HP:0002586)1.68146993
155Personality changes (HP:0000751)1.67698261
156Abnormality of the musculature of the pelvis (HP:0001469)1.67595134
157Abnormality of the hip-girdle musculature (HP:0001445)1.67595134
158Abnormality of the Achilles tendon (HP:0005109)1.67183867
159Malnutrition (HP:0004395)1.67104354
160Intestinal polyposis (HP:0200008)1.66977230
161Abnormality of the left ventricular outflow tract (HP:0011103)1.66960493
162Subaortic stenosis (HP:0001682)1.66960493
163Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.66913482
164Freckling (HP:0001480)1.66880406
165Apathy (HP:0000741)1.65865036
166Oral leukoplakia (HP:0002745)1.65463515
167Aneurysm (HP:0002617)1.64902449
168Carpal bone hypoplasia (HP:0001498)1.64016516
169Ragged-red muscle fibers (HP:0003200)1.63415883
170Camptodactyly of toe (HP:0001836)1.62745191
171Fragile skin (HP:0001030)1.62394224
172Nonimmune hydrops fetalis (HP:0001790)1.60913996
173Scapular winging (HP:0003691)1.60770084
174Melanoma (HP:0002861)1.60309113
175Micronodular cirrhosis (HP:0001413)1.57618657
176Lipoatrophy (HP:0100578)1.57245023
177Hypoplasia of the pons (HP:0012110)1.56420070
178Overlapping toe (HP:0001845)1.56276294
179Proximal placement of thumb (HP:0009623)1.56227588
180Abnormality of dentin (HP:0010299)1.55466175
181Myoglobinuria (HP:0002913)1.55420469
182Limb-girdle muscle weakness (HP:0003325)1.54315674
183Aplasia/Hypoplasia of the patella (HP:0006498)1.54165024
184Metaphyseal cupping (HP:0003021)1.52156705

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.98820481
2TRIB33.72567704
3PKN23.53749935
4SMG13.00948739
5NEK12.75214516
6MAPKAPK32.50569999
7PRPF4B2.45389555
8MAP3K102.43247801
9TESK12.34739259
10BUB12.33559926
11SIK12.21351751
12RPS6KB22.18888967
13TTN2.16018989
14PAK42.11138576
15IRAK32.06229116
16SCYL22.04877933
17ERN12.03749930
18TGFBR11.92809370
19TIE11.80471850
20WEE11.76554417
21EPHB11.74008763
22ACVR1B1.73511965
23NEK21.70994771
24LRRK21.64522479
25MAP2K31.62951993
26CDC71.62149547
27FLT31.61022188
28RIPK41.59395866
29EIF2AK11.58874805
30RPS6KA41.58408314
31ICK1.58153183
32STK101.55415794
33IRAK41.52519699
34ARAF1.51721291
35PRKD21.51107868
36TESK21.49707561
37KSR21.40361007
38TYK21.35446777
39MAP3K81.35059298
40SIK31.33153958
41PASK1.30548642
42LIMK11.29827991
43GRK61.29307131
44BLK1.28277362
45TNK21.26872742
46CDK191.25902171
47TSSK61.24624877
48LATS21.22686026
49PLK41.20738103
50EPHA21.16224946
51TTK1.12924161
52MAP3K11.12581135
53ILK1.12023643
54MAP3K111.10863938
55CSK1.10665427
56NME21.06303526
57TBK11.06106914
58PIM21.03054680
59KDR0.98425308
60BRSK20.97631519
61MAP3K130.97288731
62MAP3K60.95683678
63PDK30.94203149
64PDK40.94203149
65ZAP700.91023843
66MAP4K10.88174003
67PTK60.87176244
68MYLK0.86998412
69AURKB0.86106051
70MARK20.85879928
71TAOK20.84214243
72NEK90.81362798
73PLK10.81294475
74CDK40.81251611
75DYRK30.81154395
76BRSK10.79872449
77CDK70.78261521
78ABL20.77554961
79PDGFRA0.76524924
80MAP2K10.74161614
81PAK20.73153109
82CDC42BPA0.72877150
83BMX0.72561382
84FGR0.72415024
85ATR0.72122488
86AURKA0.67448180
87BRAF0.65613468
88MAP3K140.65545040
89DYRK1B0.63990032
90PAK10.62787119
91JAK30.62684783
92PTK20.61677151
93FGFR40.61389230
94RPS6KL10.61285339
95RPS6KC10.61285339
96RAF10.61134067
97MTOR0.60934636
98ALK0.60555893
99CSF1R0.59776622
100LMTK20.58628241
101RIPK10.56740047
102PRKD30.54959447
103CDK80.54593568
104MAP3K30.54466572
105PDPK10.53271593
106SIK20.52102391
107FES0.52088706
108PIM10.51503585
109HCK0.49606070
110ERBB30.48422475
111MST1R0.48017885
112DAPK10.46935641
113TAOK10.46766528
114CDK60.46648809
115KIT0.46135245
116TRPM70.45722281
117STK380.44933119
118FGFR10.44766222
119DMPK0.44285256
120STK240.44060427
121MAP3K50.43698479
122RET0.42534846
123MAPKAPK20.42508487
124CDK120.42024345
125CHEK20.41122728
126VRK20.41048635
127CHEK10.41046296
128BTK0.40060658
129IKBKE0.39944960
130BCKDK0.39700816
131RPS6KA60.39647801
132PLK30.39456238
133PRKG20.38530683
134PRKCI0.37972426
135MAP3K120.37851590
136DAPK30.37213488
137CDK90.36704232
138EPHB20.36682562
139MOS0.36347201
140MAPK110.36344784
141MAP2K20.35838159
142RPS6KA20.35642669
143STK160.35607201
144PIK3CA0.35327393
145AKT20.35291434
146CLK10.35192409
147HIPK20.33580717
148LCK0.32980936
149PRKD10.30525901
150JAK20.28148240
151MAP2K40.27532021

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.42540530
2Base excision repair_Homo sapiens_hsa034102.80104376
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.63899804
4RNA transport_Homo sapiens_hsa030132.59528830
5Mismatch repair_Homo sapiens_hsa034302.54398422
6Cell cycle_Homo sapiens_hsa041102.50796303
7Proteasome_Homo sapiens_hsa030502.36625276
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26329152
9Spliceosome_Homo sapiens_hsa030402.24177729
10Sulfur relay system_Homo sapiens_hsa041222.17367377
11Osteoclast differentiation_Homo sapiens_hsa043802.03895143
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94450016
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.89030193
14Ribosome_Homo sapiens_hsa030101.71851222
15p53 signaling pathway_Homo sapiens_hsa041151.71848814
16Nucleotide excision repair_Homo sapiens_hsa034201.70563944
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.63882464
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62236039
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.61386323
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.58439701
21One carbon pool by folate_Homo sapiens_hsa006701.46227769
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.43434850
23Thyroid cancer_Homo sapiens_hsa052161.42687206
24Chronic myeloid leukemia_Homo sapiens_hsa052201.41308570
25Homologous recombination_Homo sapiens_hsa034401.41262103
26Shigellosis_Homo sapiens_hsa051311.39912563
27Lysosome_Homo sapiens_hsa041421.38355097
28Bladder cancer_Homo sapiens_hsa052191.37742980
29RNA polymerase_Homo sapiens_hsa030201.36689784
30Legionellosis_Homo sapiens_hsa051341.31336870
31Tuberculosis_Homo sapiens_hsa051521.31258782
32Hepatitis C_Homo sapiens_hsa051601.30741990
33Primary immunodeficiency_Homo sapiens_hsa053401.29575199
34RNA degradation_Homo sapiens_hsa030181.27373829
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.26649810
36Pyrimidine metabolism_Homo sapiens_hsa002401.26575813
37Non-homologous end-joining_Homo sapiens_hsa034501.24572669
38Small cell lung cancer_Homo sapiens_hsa052221.24100313
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23441564
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.22789458
41Epstein-Barr virus infection_Homo sapiens_hsa051691.21475628
42Viral myocarditis_Homo sapiens_hsa054161.19913153
43Viral carcinogenesis_Homo sapiens_hsa052031.19149331
44mRNA surveillance pathway_Homo sapiens_hsa030151.19108966
45HTLV-I infection_Homo sapiens_hsa051661.18312613
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13576922
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13267121
48HIF-1 signaling pathway_Homo sapiens_hsa040661.13115193
49Adherens junction_Homo sapiens_hsa045201.11340006
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.10118847
51Colorectal cancer_Homo sapiens_hsa052101.08851582
52Carbon metabolism_Homo sapiens_hsa012001.08829392
53Antigen processing and presentation_Homo sapiens_hsa046121.08230124
54Biosynthesis of amino acids_Homo sapiens_hsa012301.07536643
55Central carbon metabolism in cancer_Homo sapiens_hsa052301.06423833
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05568776
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04351184
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02416709
59Malaria_Homo sapiens_hsa051441.02356129
60Oocyte meiosis_Homo sapiens_hsa041141.00911885
61Apoptosis_Homo sapiens_hsa042101.00169595
62Focal adhesion_Homo sapiens_hsa045101.00133458
63Hippo signaling pathway_Homo sapiens_hsa043900.99762549
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98223526
65Proteoglycans in cancer_Homo sapiens_hsa052050.97826674
66Pancreatic cancer_Homo sapiens_hsa052120.96224193
67Vibrio cholerae infection_Homo sapiens_hsa051100.96151960
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.92913410
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91197745
70Phagosome_Homo sapiens_hsa041450.91043515
71MicroRNAs in cancer_Homo sapiens_hsa052060.91011395
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89268800
73Leishmaniasis_Homo sapiens_hsa051400.89188313
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86683181
75T cell receptor signaling pathway_Homo sapiens_hsa046600.85636425
76Herpes simplex infection_Homo sapiens_hsa051680.84601348
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84289360
78Renal cell carcinoma_Homo sapiens_hsa052110.84094461
79Acute myeloid leukemia_Homo sapiens_hsa052210.82636689
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82316685
81Endometrial cancer_Homo sapiens_hsa052130.80339496
82Pentose phosphate pathway_Homo sapiens_hsa000300.80135418
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78518012
84N-Glycan biosynthesis_Homo sapiens_hsa005100.77930974
85Toxoplasmosis_Homo sapiens_hsa051450.77171312
86Hepatitis B_Homo sapiens_hsa051610.76043495
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.75318774
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74789986
89Chemokine signaling pathway_Homo sapiens_hsa040620.74757552
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73757558
91mTOR signaling pathway_Homo sapiens_hsa041500.73702860
92VEGF signaling pathway_Homo sapiens_hsa043700.72175533
93Non-small cell lung cancer_Homo sapiens_hsa052230.70985989
94TGF-beta signaling pathway_Homo sapiens_hsa043500.70931984
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69873461
96Staphylococcus aureus infection_Homo sapiens_hsa051500.69212384
97Basal transcription factors_Homo sapiens_hsa030220.69053252
98Fructose and mannose metabolism_Homo sapiens_hsa000510.68049527
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.67791232
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.66528398
101Influenza A_Homo sapiens_hsa051640.63768397
102Selenocompound metabolism_Homo sapiens_hsa004500.62523407
103Tight junction_Homo sapiens_hsa045300.60711712
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60394336
105ECM-receptor interaction_Homo sapiens_hsa045120.59981625
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.59285651
107Pathways in cancer_Homo sapiens_hsa052000.59198335
108Choline metabolism in cancer_Homo sapiens_hsa052310.58627922
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58526691
110Fanconi anemia pathway_Homo sapiens_hsa034600.58510283
111Salmonella infection_Homo sapiens_hsa051320.57602725
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57277121
113Notch signaling pathway_Homo sapiens_hsa043300.56489307
114Prion diseases_Homo sapiens_hsa050200.56242288
115Pertussis_Homo sapiens_hsa051330.54435953
116Dilated cardiomyopathy_Homo sapiens_hsa054140.54403667
117Purine metabolism_Homo sapiens_hsa002300.53953702
118Insulin signaling pathway_Homo sapiens_hsa049100.52851798
119Galactose metabolism_Homo sapiens_hsa000520.52427056
120Basal cell carcinoma_Homo sapiens_hsa052170.52210023
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51464278
122Platelet activation_Homo sapiens_hsa046110.51408269
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49738612
124Endocytosis_Homo sapiens_hsa041440.49360506
125ErbB signaling pathway_Homo sapiens_hsa040120.49305365
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49203832
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48422897
128TNF signaling pathway_Homo sapiens_hsa046680.46430011
129Measles_Homo sapiens_hsa051620.46422970
130Prostate cancer_Homo sapiens_hsa052150.45977204
131Other glycan degradation_Homo sapiens_hsa005110.45497539
132Glioma_Homo sapiens_hsa052140.45380010
133Hematopoietic cell lineage_Homo sapiens_hsa046400.44721639
134B cell receptor signaling pathway_Homo sapiens_hsa046620.43770228
135Insulin resistance_Homo sapiens_hsa049310.43317033
136Amoebiasis_Homo sapiens_hsa051460.42587122
137PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42104495

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