MAEL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptonemal complex organization (GO:0070193)9.95055044
2multicellular organism reproduction (GO:0032504)9.87611047
3cell wall macromolecule metabolic process (GO:0044036)9.86784857
4cell wall macromolecule catabolic process (GO:0016998)9.86784857
5synaptonemal complex assembly (GO:0007130)9.83656978
6binding of sperm to zona pellucida (GO:0007339)9.61267146
7* synapsis (GO:0007129)9.48314016
8acrosome reaction (GO:0007340)9.47380383
9axonemal dynein complex assembly (GO:0070286)9.43452102
10* male meiosis (GO:0007140)9.31325097
11cell-cell recognition (GO:0009988)9.26186656
12plasma membrane fusion (GO:0045026)9.25658190
13spermatid development (GO:0007286)8.89355494
14epithelial cilium movement (GO:0003351)8.67010832
15motile cilium assembly (GO:0044458)8.36873210
16reproduction (GO:0000003)8.16847887
17* DNA methylation involved in gamete generation (GO:0043046)7.64317901
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.40641823
19cilium movement (GO:0003341)7.37759109
20regulation of cilium movement (GO:0003352)7.12367937
21male meiosis I (GO:0007141)7.05076012
22single fertilization (GO:0007338)6.64639125
23* meiotic nuclear division (GO:0007126)6.18625080
24* chromosome organization involved in meiosis (GO:0070192)6.18375707
25* spermatogenesis (GO:0007283)6.12987086
26* male gamete generation (GO:0048232)6.11127964
27negative regulation of inclusion body assembly (GO:0090084)5.97937082
28* fertilization (GO:0009566)5.84748082
29sperm capacitation (GO:0048240)5.81929805
30meiosis I (GO:0007127)5.78327328
31* gamete generation (GO:0007276)5.64542834
32germ cell development (GO:0007281)5.59363538
33female gamete generation (GO:0007292)5.53703052
34microtubule depolymerization (GO:0007019)5.48781223
35resolution of meiotic recombination intermediates (GO:0000712)5.43140662
36positive regulation of meiosis (GO:0045836)5.42464156
37meiotic chromosome segregation (GO:0045132)5.40085893
38cellular process involved in reproduction in multicellular organism (GO:0022412)5.38950998
39DNA synthesis involved in DNA repair (GO:0000731)5.30158402
40regulation of meiosis I (GO:0060631)5.19842465
41positive regulation of meiotic cell cycle (GO:0051446)5.06078194
42meiotic cell cycle (GO:0051321)4.87033477
43regulation of inclusion body assembly (GO:0090083)4.85490080
44ventricular system development (GO:0021591)4.73109849
45organic cation transport (GO:0015695)4.69764004
46seminiferous tubule development (GO:0072520)4.66005284
47* multicellular organismal reproductive process (GO:0048609)4.41057299
48cell recognition (GO:0008037)4.36406977
49microtubule severing (GO:0051013)4.35605449
50monoubiquitinated protein deubiquitination (GO:0035520)4.29375061
51* gene silencing by RNA (GO:0031047)4.26920483
52regulation of microtubule-based movement (GO:0060632)4.25084622
53calcium ion-dependent exocytosis (GO:0017156)4.24538209
54regulation of meiotic cell cycle (GO:0051445)4.20351735
55negative regulation of meiosis (GO:0045835)4.12093306
56* meiotic cell cycle process (GO:1903046)4.07971710
57regulation of meiosis (GO:0040020)4.02552832
58DNA packaging (GO:0006323)4.01229594
59chromosome condensation (GO:0030261)4.00828526
60regulation of female gonad development (GO:2000194)3.90155324
61genitalia morphogenesis (GO:0035112)3.88098660
62spermatid nucleus differentiation (GO:0007289)3.87032176
63chaperone-mediated protein complex assembly (GO:0051131)3.83895680
64histone H3-K9 demethylation (GO:0033169)3.75710467
65oocyte development (GO:0048599)3.72874103
66nuclear pore complex assembly (GO:0051292)3.72017427
67protein localization to cilium (GO:0061512)3.71406039
68negative regulation of gene silencing (GO:0060969)3.61959175
69left/right pattern formation (GO:0060972)3.61597313
70attachment of spindle microtubules to kinetochore (GO:0008608)3.61496447
71proteasome assembly (GO:0043248)3.59985475
72regulation of acrosome reaction (GO:0060046)3.53234802
73* multicellular organismal development (GO:0007275)3.48864461
74glycerol ether metabolic process (GO:0006662)3.48542494
75mitotic sister chromatid cohesion (GO:0007064)3.42113880
76CENP-A containing nucleosome assembly (GO:0034080)3.40628950
77protein polyglutamylation (GO:0018095)3.39608771
78regulation of spindle checkpoint (GO:0090231)3.37007265
79intraciliary transport (GO:0042073)3.34956321
80chromatin remodeling at centromere (GO:0031055)3.33661177
81regulation of centriole replication (GO:0046599)3.27945049
82mitotic chromosome condensation (GO:0007076)3.26350361
83retinal cone cell development (GO:0046549)3.25960082
84regulation of DNA methylation (GO:0044030)3.25194012
85nuclear pore organization (GO:0006999)3.22228549
86* gene silencing (GO:0016458)3.21937248
87ether metabolic process (GO:0018904)3.21114692
88sister chromatid cohesion (GO:0007062)3.21086852
89protein K6-linked ubiquitination (GO:0085020)3.16581186
90negative regulation of organelle assembly (GO:1902116)3.14898279
91somatic diversification of immune receptors via somatic mutation (GO:0002566)3.14170359
92somatic hypermutation of immunoglobulin genes (GO:0016446)3.14170359
93* DNA alkylation (GO:0006305)3.13084013
94* DNA methylation (GO:0006306)3.13084013
95nucleus organization (GO:0006997)3.09662069
96protein K11-linked deubiquitination (GO:0035871)3.09346776
97negative regulation of meiotic cell cycle (GO:0051447)3.06938270
98single strand break repair (GO:0000012)3.00895707
99regulation of DNA endoreduplication (GO:0032875)3.00432120
100axoneme assembly (GO:0035082)3.00387939
101mitotic metaphase plate congression (GO:0007080)2.95156673
102protein refolding (GO:0042026)2.93924191
103protein localization to chromosome (GO:0034502)2.92616806
104* DNA methylation or demethylation (GO:0044728)2.89207008
105microtubule polymerization or depolymerization (GO:0031109)2.88363444
106DNA replication checkpoint (GO:0000076)2.88292795
107amino-acid betaine transport (GO:0015838)2.87946649
108carnitine transport (GO:0015879)2.87946649
109regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.86417634
110regulation of mitotic spindle checkpoint (GO:1903504)2.86417634
111histone exchange (GO:0043486)2.86194944
112microtubule-based movement (GO:0007018)2.86063435
113pore complex assembly (GO:0046931)2.84768985
114carnitine transmembrane transport (GO:1902603)2.84006590
115sex differentiation (GO:0007548)2.82510347
116interkinetic nuclear migration (GO:0022027)2.82061819
117regulation of protein polyubiquitination (GO:1902914)2.81761964
118regulation of histone H3-K9 methylation (GO:0051570)2.81231367
119centriole replication (GO:0007099)2.79612318
120reciprocal meiotic recombination (GO:0007131)2.79116091
121reciprocal DNA recombination (GO:0035825)2.79116091
122histone H2A acetylation (GO:0043968)2.78071948
123positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.77560517
124positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.77560517
125positive regulation of mitotic sister chromatid separation (GO:1901970)2.77560517
126lactate metabolic process (GO:0006089)2.76417638
127DNA replication-dependent nucleosome assembly (GO:0006335)2.75245707
128DNA replication-dependent nucleosome organization (GO:0034723)2.75245707
129oogenesis (GO:0048477)2.75219328
130cilium organization (GO:0044782)2.73641655
131centriole assembly (GO:0098534)2.70126580
132metaphase plate congression (GO:0051310)2.68505979
133heterochromatin organization (GO:0070828)2.68161834
134* chromosome organization (GO:0051276)2.67947950
135* nuclear division (GO:0000280)2.66785131
136* DNA modification (GO:0006304)2.60741504
137oocyte maturation (GO:0001556)2.58475322
138DNA biosynthetic process (GO:0071897)2.57149106
139* organelle fission (GO:0048285)2.51312833
140regulation of double-strand break repair via homologous recombination (GO:0010569)2.50760566
141fusion of sperm to egg plasma membrane (GO:0007342)12.2268359
142cilium or flagellum-dependent cell motility (GO:0001539)11.4523490
143sperm motility (GO:0030317)11.3807684
144* piRNA metabolic process (GO:0034587)11.3361953
145acrosome assembly (GO:0001675)10.6246866
146sperm-egg recognition (GO:0035036)10.3602978

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.34621433
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.31005875
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.45654572
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.44173154
5* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.65604393
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.52617828
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.43026419
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38523975
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.31000609
10GATA1_26923725_Chip-Seq_HPCs_Mouse2.30537964
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.25013313
12IGF1R_20145208_ChIP-Seq_DFB_Human2.08977621
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.07533761
14E2F7_22180533_ChIP-Seq_HELA_Human2.06048567
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00842835
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.8181372
17PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97255735
18ZNF274_21170338_ChIP-Seq_K562_Hela1.96249485
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94109256
20E2F4_17652178_ChIP-ChIP_JURKAT_Human1.87978631
21FUS_26573619_Chip-Seq_HEK293_Human1.85165849
22ELK4_26923725_Chip-Seq_MESODERM_Mouse1.84284681
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.81461930
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.80219096
25VDR_22108803_ChIP-Seq_LS180_Human1.77829721
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.75422275
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.71834612
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70245691
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69645357
30KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.69324405
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67065981
32RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.66833936
33KAP1_22055183_ChIP-Seq_ESCs_Mouse1.65382812
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63625785
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.61479285
36FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61377660
37STAT1_17558387_ChIP-Seq_HELA_Human1.60523513
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59239936
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.58228542
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.58228542
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.58228542
42TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.57908606
43EWS_26573619_Chip-Seq_HEK293_Human1.55427083
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54986086
45ER_23166858_ChIP-Seq_MCF-7_Human1.54649650
46GBX2_23144817_ChIP-Seq_PC3_Human1.54395290
47WDR5_24793694_ChIP-Seq_LNCAP_Human1.52270265
48MYC_18940864_ChIP-ChIP_HL60_Human1.46930571
49* TP53_22573176_ChIP-Seq_HFKS_Human1.46385106
50SMAD4_21741376_ChIP-Seq_EPCs_Human1.45930993
51GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.45456093
52BCAT_22108803_ChIP-Seq_LS180_Human1.44190966
53P300_19829295_ChIP-Seq_ESCs_Human1.43867876
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39113494
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38445888
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37688761
57SOX2_22085726_ChIP-Seq_NPCs_Mouse1.37405876
58AR_25329375_ChIP-Seq_VCAP_Human1.36488502
59* GATA3_21867929_ChIP-Seq_CD8_Mouse1.35547651
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34858086
61RUNX2_22187159_ChIP-Seq_PCA_Human1.34138683
62VDR_23849224_ChIP-Seq_CD4+_Human1.33930099
63IRF1_19129219_ChIP-ChIP_H3396_Human1.32792016
64MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32373121
65RUNX1_26923725_Chip-Seq_HPCs_Mouse1.31773617
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31583616
67TAL1_26923725_Chip-Seq_HPCs_Mouse1.31515450
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30050524
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.30050524
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29962534
71RNF2_27304074_Chip-Seq_NSC_Mouse1.29566521
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29415438
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.28963379
74GATA3_21867929_ChIP-Seq_TH1_Mouse1.27624845
75* NFE2_27457419_Chip-Seq_LIVER_Mouse1.27423168
76FOXH1_21741376_ChIP-Seq_EPCs_Human1.27415976
77STAT3_23295773_ChIP-Seq_U87_Human1.26760501
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25955084
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24225887
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24012039
81TCF4_23295773_ChIP-Seq_U87_Human1.23758587
82NANOG_19829295_ChIP-Seq_ESCs_Human1.21896763
83SOX2_19829295_ChIP-Seq_ESCs_Human1.21896763
84* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.21675774
85CBP_20019798_ChIP-Seq_JUKART_Human1.21628815
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21628815
87KDM2B_26808549_Chip-Seq_REH_Human1.21507338
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20844429
89TAF15_26573619_Chip-Seq_HEK293_Human1.20580165
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20080432
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.19920173
92SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19511163
93FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19130402
94HTT_18923047_ChIP-ChIP_STHdh_Human1.18230003
95FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17873802
96LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.17531578
97HOXB7_26014856_ChIP-Seq_BT474_Human1.17481423
98AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14897366
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14401467
100CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13628518
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12897718
102SMAD4_21799915_ChIP-Seq_A2780_Human1.12876270
103ERA_21632823_ChIP-Seq_H3396_Human1.12237386
104P53_21459846_ChIP-Seq_SAOS-2_Human1.11953309
105AR_20517297_ChIP-Seq_VCAP_Human1.11924950
106CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11609602
107* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10623000
108FOXM1_23109430_ChIP-Seq_U2OS_Human1.10296172
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10170759
110FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09867709
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.09731358
112* GATA3_21878914_ChIP-Seq_MCF-7_Human1.08344365
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05838339
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05838339
115PRDM14_20953172_ChIP-Seq_ESCs_Human1.05463761
116MYC_19829295_ChIP-Seq_ESCs_Human1.05323032
117ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05183488
118PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04343133
119ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04238026
120GF1_26923725_Chip-Seq_HPCs_Mouse1.03988069
121CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03512692
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02311655
123SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01582541
124JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.00901685
125TCF4_22108803_ChIP-Seq_LS180_Human1.00883948
126NCOR_22424771_ChIP-Seq_293T_Human1.00831866
127GATA3_26560356_Chip-Seq_TH1_Human0.99769976
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99385440
129SPI1_26923725_Chip-Seq_HPCs_Mouse0.99221930
130* CRX_20693478_ChIP-Seq_RETINA_Mouse0.99052380
131CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97980698
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96055945
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95864955
134YY1_22570637_ChIP-Seq_MALME-3M_Human0.95827316
135NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95128027
136* OCT4_18555785_Chip-Seq_ESCs_Mouse0.95033906
137ERG_20517297_ChIP-Seq_VCAP_Human0.94905556
138RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94259577
139CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94000268
140* NANOG_18555785_Chip-Seq_ESCs_Mouse0.93794231
141* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93623713
142RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93451411
143PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93384770
144ESET_19884257_ChIP-Seq_ESCs_Mouse0.92908314
145FOXP3_21729870_ChIP-Seq_TREG_Human0.92744223
146SMAD3_21741376_ChIP-Seq_EPCs_Human0.92349280
147* LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92325139
148AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91920853
149REST_21632747_ChIP-Seq_MESCs_Mouse0.91625132
150TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90390962
151PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90145336
152CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90028395
153EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89329105
154RARA_24833708_ChIP-Seq_LIVER_Mouse0.89284628
155TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87604788
156* KLF4_18555785_Chip-Seq_ESCs_Mouse0.87129997
157FLI1_21867929_ChIP-Seq_CD8_Mouse0.86911641
158* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86653797
159CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86112405
160* EZH2_27294783_Chip-Seq_NPCs_Mouse0.85161598
161PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84997760
162* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.84222448
163RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84004823
164* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.83688431
165NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.82840016
166* P53_22387025_ChIP-Seq_ESCs_Mouse0.82545812
167SOX9_26525672_Chip-Seq_HEART_Mouse0.82027066
168* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81658658
169GF1B_26923725_Chip-Seq_HPCs_Mouse0.80906633
170* P300_18555785_Chip-Seq_ESCs_Mouse0.80400310
171* SOX2_21211035_ChIP-Seq_LN229_Human0.80394003
172* NFYB_21822215_ChIP-Seq_K562_Human0.80344058
173SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78154787
174MYC_27129775_Chip-Seq_CORNEA_Mouse0.78091890

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive6.01991647
2* MP0001929_abnormal_gametogenesis5.88372672
3* MP0008877_abnormal_DNA_methylation5.26185368
4* MP0002210_abnormal_sex_determination4.45935558
5* MP0001145_abnormal_male_reproductive3.70112660
6* MP0002161_abnormal_fertility/fecundity3.34027080
7* MP0000653_abnormal_sex_gland3.27352296
8MP0002653_abnormal_ependyma_morphology2.93894201
9MP0006292_abnormal_olfactory_placode2.77147078
10MP0008789_abnormal_olfactory_epithelium2.36890510
11MP0008995_early_reproductive_senescence2.35069466
12MP0008057_abnormal_DNA_replication2.34075489
13MP0008058_abnormal_DNA_repair2.11981946
14MP0002160_abnormal_reproductive_system2.08302879
15MP0010094_abnormal_chromosome_stability2.03317841
16MP0005410_abnormal_fertilization13.8930465
17MP0009379_abnormal_foot_pigmentation1.94544345
18MP0003646_muscle_fatigue1.84035319
19MP0005394_taste/olfaction_phenotype1.80809868
20MP0005499_abnormal_olfactory_system1.80809868
21MP0005623_abnormal_meninges_morphology1.80251605
22MP0005670_abnormal_white_adipose1.77196315
23MP0003786_premature_aging1.75474199
24MP0010368_abnormal_lymphatic_system1.59531310
25MP0005395_other_phenotype1.56474760
26MP0003136_yellow_coat_color1.51016858
27MP0000383_abnormal_hair_follicle1.47905328
28MP0001986_abnormal_taste_sensitivity1.38594542
29MP0005174_abnormal_tail_pigmentation1.33164614
30MP0003111_abnormal_nucleus_morphology1.33069371
31MP0010030_abnormal_orbit_morphology1.33048330
32MP0004233_abnormal_muscle_weight1.32092797
33MP0003119_abnormal_digestive_system1.24666548
34MP0005647_abnormal_sex_gland1.24169789
35MP0008007_abnormal_cellular_replicative1.21929879
36MP0000631_abnormal_neuroendocrine_gland1.21496596
37MP0003183_abnormal_peptide_metabolism1.17900071
38MP0000566_synostosis1.17688387
39MP0002282_abnormal_trachea_morphology1.13998522
40MP0000678_abnormal_parathyroid_gland1.12533174
41MP0001485_abnormal_pinna_reflex1.12413078
42MP0005389_reproductive_system_phenotype1.10837034
43MP0010678_abnormal_skin_adnexa1.06025809
44MP0003077_abnormal_cell_cycle1.01912238
45MP0001919_abnormal_reproductive_system1.00448242
46MP0002638_abnormal_pupillary_reflex0.98841766
47MP0002272_abnormal_nervous_system0.97853540
48MP0004142_abnormal_muscle_tone0.97299031
49MP0001730_embryonic_growth_arrest0.89220948
50MP0001119_abnormal_female_reproductive0.88882737
51MP0001486_abnormal_startle_reflex0.88781240
52MP0006035_abnormal_mitochondrial_morpho0.88566985
53MP0004215_abnormal_myocardial_fiber0.88549613
54MP0003878_abnormal_ear_physiology0.86901019
55MP0005377_hearing/vestibular/ear_phenot0.86901019
56MP0003699_abnormal_female_reproductive0.86453613
57MP0002735_abnormal_chemical_nociception0.86072441
58MP0002095_abnormal_skin_pigmentation0.84787340
59MP0010307_abnormal_tumor_latency0.83598655
60MP0004885_abnormal_endolymph0.82779596
61MP0002139_abnormal_hepatobiliary_system0.82099070
62MP0009745_abnormal_behavioral_response0.81601823
63MP0001984_abnormal_olfaction0.80627004
64MP0001963_abnormal_hearing_physiology0.80146412
65MP0002138_abnormal_hepatobiliary_system0.78638935
66MP0000026_abnormal_inner_ear0.78487490
67MP0002233_abnormal_nose_morphology0.76902971
68MP0003693_abnormal_embryo_hatching0.75403804
69MP0000647_abnormal_sebaceous_gland0.75386768
70MP0004808_abnormal_hematopoietic_stem0.74346967
71MP0001529_abnormal_vocalization0.73983052
72MP0005360_urolithiasis0.73799694
73MP0004957_abnormal_blastocyst_morpholog0.73442976
74MP0009046_muscle_twitch0.70890313
75MP0001765_abnormal_ion_homeostasis0.70861616
76MP0000569_abnormal_digit_pigmentation0.70626338
77MP0003937_abnormal_limbs/digits/tail_de0.70254442
78MP0006276_abnormal_autonomic_nervous0.69412331
79MP0003115_abnormal_respiratory_system0.69103648
80MP0000049_abnormal_middle_ear0.67145497
81MP0001502_abnormal_circadian_rhythm0.65724873
82MP0005645_abnormal_hypothalamus_physiol0.63065453
83MP0005646_abnormal_pituitary_gland0.61257077
84MP0005397_hematopoietic_system_phenotyp0.59938177
85MP0001545_abnormal_hematopoietic_system0.59938177
86MP0001968_abnormal_touch/_nociception0.59904864
87MP0000358_abnormal_cell_content/0.59766768
88MP0008875_abnormal_xenobiotic_pharmacok0.58579287
89MP0003011_delayed_dark_adaptation0.58473379
90MP0002234_abnormal_pharynx_morphology0.58417008
91MP0005386_behavior/neurological_phenoty0.57999480
92MP0004924_abnormal_behavior0.57999480
93MP0002067_abnormal_sensory_capabilities0.57407618
94MP0004742_abnormal_vestibular_system0.57043309
95MP0001293_anophthalmia0.56863463
96MP0009278_abnormal_bone_marrow0.55690719
97MP0002084_abnormal_developmental_patter0.53833408
98MP0000313_abnormal_cell_death0.50825918
99MP0005380_embryogenesis_phenotype0.49619669
100MP0001672_abnormal_embryogenesis/_devel0.49619669
101MP0008932_abnormal_embryonic_tissue0.49448773
102MP0001697_abnormal_embryo_size0.48488446
103MP0003123_paternal_imprinting0.47557954
104MP0003787_abnormal_imprinting0.46830425
105MP0005666_abnormal_adipose_tissue0.45790213
106MP0004036_abnormal_muscle_relaxation0.45082978
107MP0002102_abnormal_ear_morphology0.44312882
108MP0002085_abnormal_embryonic_tissue0.44271824
109MP0003950_abnormal_plasma_membrane0.42297364
110MP0004134_abnormal_chest_morphology0.41068360
111MP0003984_embryonic_growth_retardation0.41049876
112MP0002269_muscular_atrophy0.40457988
113MP0003861_abnormal_nervous_system0.40196669
114MP0001661_extended_life_span0.39544104
115MP0000427_abnormal_hair_cycle0.38487998
116MP0002080_prenatal_lethality0.37950551
117MP0002088_abnormal_embryonic_growth/wei0.37219248
118MP0001727_abnormal_embryo_implantation0.36576055
119MP0004197_abnormal_fetal_growth/weight/0.35690624
120MP0002928_abnormal_bile_duct0.35399235
121MP0005391_vision/eye_phenotype0.35363546
122MP0003936_abnormal_reproductive_system0.34776569
123MP0005253_abnormal_eye_physiology0.34750388
124MP0000350_abnormal_cell_proliferation0.33508781
125MP0003718_maternal_effect0.32594692
126MP0006036_abnormal_mitochondrial_physio0.31680553
127MP0003890_abnormal_embryonic-extraembry0.30472369
128MP0001324_abnormal_eye_pigmentation0.30205922
129MP0000534_abnormal_ureter_morphology0.28321695
130MP0002092_abnormal_eye_morphology0.28185249
131MP0009672_abnormal_birth_weight0.27407333
132MP0005636_abnormal_mineral_homeostasis0.25863500
133MP0009115_abnormal_fat_cell0.25577568
134MP0005551_abnormal_eye_electrophysiolog0.25406173
135MP0003942_abnormal_urinary_system0.24770345
136MP0003315_abnormal_perineum_morphology0.24612397
137MP0002971_abnormal_brown_adipose0.23816336
138MP0000432_abnormal_head_morphology0.23645828
139MP0002152_abnormal_brain_morphology0.23206194
140MP0001764_abnormal_homeostasis0.22812261
141MP0003879_abnormal_hair_cell0.21690113
142MP0002019_abnormal_tumor_incidence0.21638543
143MP0005076_abnormal_cell_differentiation0.21399795
144MP0002086_abnormal_extraembryonic_tissu0.20248687
145MP0001915_intracranial_hemorrhage0.19963397
146MP0001849_ear_inflammation0.19521164
147MP0004133_heterotaxia0.18899596
148MP0009703_decreased_birth_body0.18439660
149MP0006072_abnormal_retinal_apoptosis0.18282131
150MP0003121_genomic_imprinting0.17943872

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.05922496
2Abnormal respiratory motile cilium morphology (HP:0005938)8.48639919
3Abnormal respiratory epithelium morphology (HP:0012253)8.48639919
4Rhinitis (HP:0012384)7.61576412
5Abnormal ciliary motility (HP:0012262)7.19297129
6Chronic bronchitis (HP:0004469)7.16072651
7Infertility (HP:0000789)6.43344205
8Nasal polyposis (HP:0100582)6.05634162
9Abnormality of the nasal mucosa (HP:0000433)4.92734278
10Oligodactyly (hands) (HP:0001180)4.55758091
11Bronchiectasis (HP:0002110)4.43768247
12Nephronophthisis (HP:0000090)4.43719898
13Abnormal spermatogenesis (HP:0008669)4.37062662
14Bronchitis (HP:0012387)4.31363253
15Male infertility (HP:0003251)4.10054543
16Abnormality of the lower motor neuron (HP:0002366)3.85192372
17Azoospermia (HP:0000027)3.78642967
18Volvulus (HP:0002580)3.78634912
19Gonadotropin excess (HP:0000837)3.68503212
20Abnormality of the renal medulla (HP:0100957)3.35034605
21Osteomalacia (HP:0002749)3.17957437
22Oligodactyly (HP:0012165)3.15536381
23Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.15248979
24Degeneration of the lateral corticospinal tracts (HP:0002314)3.15248979
25Recurrent sinusitis (HP:0011108)3.14418146
26Recurrent otitis media (HP:0000403)3.13392842
27Chromsome breakage (HP:0040012)3.12994921
28Chromosomal breakage induced by crosslinking agents (HP:0003221)3.11016660
29Tubulointerstitial nephritis (HP:0001970)2.92104838
30Amyotrophic lateral sclerosis (HP:0007354)2.86009584
31Abnormality of the labia minora (HP:0012880)2.83955419
32Pancreatic cysts (HP:0001737)2.81623197
33Impulsivity (HP:0100710)2.78333870
34Fibular hypoplasia (HP:0003038)2.72524581
35Tubular atrophy (HP:0000092)2.68879604
36Molar tooth sign on MRI (HP:0002419)2.67924462
37Abnormality of midbrain morphology (HP:0002418)2.67924462
38Type II lissencephaly (HP:0007260)2.66271233
39Anterior segment dysgenesis (HP:0007700)2.63424140
40Medial flaring of the eyebrow (HP:0010747)2.59180035
41Small intestinal stenosis (HP:0012848)2.53580255
42Duodenal stenosis (HP:0100867)2.53580255
43Short tibia (HP:0005736)2.49202733
44Abdominal situs inversus (HP:0003363)2.48132035
45Abnormality of abdominal situs (HP:0011620)2.48132035
46Tubulointerstitial abnormality (HP:0001969)2.46536614
47True hermaphroditism (HP:0010459)2.44462190
48Abnormality of the corticospinal tract (HP:0002492)2.43035425
49Recurrent bronchitis (HP:0002837)2.41556987
50Chronic hepatic failure (HP:0100626)2.38963322
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.38770032
52Horizontal nystagmus (HP:0000666)2.37675260
53Abnormality of the ileum (HP:0001549)2.35374128
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.34649989
55Meckel diverticulum (HP:0002245)2.31677198
56Abnormality of DNA repair (HP:0003254)2.26196671
57Absent thumb (HP:0009777)2.25351006
58Facial hemangioma (HP:0000329)2.21228845
59Abnormal lung lobation (HP:0002101)2.19655313
60Abnormality of the duodenum (HP:0002246)2.18457638
61Preaxial hand polydactyly (HP:0001177)2.18382208
62Upper motor neuron abnormality (HP:0002127)2.17330324
63Fair hair (HP:0002286)2.16998000
64Scotoma (HP:0000575)2.16670974
65Postaxial foot polydactyly (HP:0001830)2.15629615
66Colon cancer (HP:0003003)2.15322350
67Severe visual impairment (HP:0001141)2.14274359
68Abnormality of chromosome stability (HP:0003220)2.12879453
69Hypoplasia of the fovea (HP:0007750)2.10888816
70Aplasia/Hypoplasia of the fovea (HP:0008060)2.10888816
71Abnormality of the renal collecting system (HP:0004742)2.06872216
72Abnormality of the fovea (HP:0000493)2.05098945
73Absent septum pellucidum (HP:0001331)2.04133424
74Sclerocornea (HP:0000647)2.03652443
75Stage 5 chronic kidney disease (HP:0003774)2.03184341
76Impaired proprioception (HP:0010831)2.02109045
77Aplasia/Hypoplasia involving the musculature (HP:0001460)2.02032602
78Abnormality of the preputium (HP:0100587)2.00301463
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0408998
80Dynein arm defect of respiratory motile cilia (HP:0012255)12.1986341
81Absent/shortened dynein arms (HP:0200106)12.1986341
82Abnormality of the anterior horn cell (HP:0006802)1.98283933
83Degeneration of anterior horn cells (HP:0002398)1.98283933
84Facial cleft (HP:0002006)1.97957681
85Supernumerary spleens (HP:0009799)1.97931980
86Birth length less than 3rd percentile (HP:0003561)1.97832739
87Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96156795
88Anencephaly (HP:0002323)1.95966217
89Optic nerve hypoplasia (HP:0000609)1.95556478
90Male pseudohermaphroditism (HP:0000037)1.94371721
91Tubulointerstitial fibrosis (HP:0005576)1.94053486
92Short ribs (HP:0000773)1.93055476
9311 pairs of ribs (HP:0000878)1.91570678
94Spontaneous abortion (HP:0005268)1.91176482
95Non-midline cleft lip (HP:0100335)1.91088202
96Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89958007
97Retinal dysplasia (HP:0007973)1.89727209
98Premature ovarian failure (HP:0008209)1.88961658
99Absent radius (HP:0003974)1.88403666
100Pendular nystagmus (HP:0012043)1.88067175
101Attenuation of retinal blood vessels (HP:0007843)1.86977667
102Congenital hepatic fibrosis (HP:0002612)1.85859651
103Hypoplasia of the uterus (HP:0000013)1.85150070
104Congenital stationary night blindness (HP:0007642)1.82980785
105Aplasia/Hypoplasia of the sternum (HP:0006714)1.81213072
106Abnormality of alanine metabolism (HP:0010916)1.81041241
107Hyperalaninemia (HP:0003348)1.81041241
108Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81041241
109Microglossia (HP:0000171)1.80156946
110Shoulder girdle muscle weakness (HP:0003547)1.79858259
111Aplasia involving forearm bones (HP:0009822)1.78674329
112Absent forearm bone (HP:0003953)1.78674329
113Oculomotor apraxia (HP:0000657)1.78613241
114Heterotopia (HP:0002282)1.78142366
115Renal dysplasia (HP:0000110)1.77694922
116Aplasia/Hypoplasia of the fibula (HP:0006492)1.74558602
117Abnormality of the renal cortex (HP:0011035)1.74180838
118Abnormal drinking behavior (HP:0030082)1.73576573
119Polydipsia (HP:0001959)1.73576573
120Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.64120785
121Median cleft lip (HP:0000161)1.63265432
122Postaxial hand polydactyly (HP:0001162)1.62129307
123Spastic tetraparesis (HP:0001285)1.58911715
124Abnormality of dentin (HP:0010299)1.58878284
125Absent frontal sinuses (HP:0002688)1.58123858
126Selective tooth agenesis (HP:0001592)1.57219596
127Abnormality of the dental root (HP:0006486)1.56236557
128Taurodontia (HP:0000679)1.56236557
129Abnormality of permanent molar morphology (HP:0011071)1.56236557
130Absent epiphyses (HP:0010577)1.51753973
131Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.51753973
132Short thorax (HP:0010306)1.48144661
133Breast carcinoma (HP:0003002)1.48055637
134Congenital primary aphakia (HP:0007707)1.47889838
135Abnormality of renal excretion (HP:0011036)1.45507857
136Gait imbalance (HP:0002141)1.45242120
137Abnormality of ocular smooth pursuit (HP:0000617)1.45061271
138Abnormality of molar morphology (HP:0011070)1.44433129
139Abnormality of molar (HP:0011077)1.44433129
140Pancreatic fibrosis (HP:0100732)1.43954455
141Cystic liver disease (HP:0006706)1.42197532
142Aplasia/Hypoplasia of the tongue (HP:0010295)1.41701585
143Abnormality of the dental pulp (HP:0006479)1.40344030
144Bell-shaped thorax (HP:0001591)1.38600991
145Chronic sinusitis (HP:0011109)1.37884853
146J-shaped sella turcica (HP:0002680)1.35201446
147Bile duct proliferation (HP:0001408)1.34522314
148Abnormal biliary tract physiology (HP:0012439)1.34522314
149Dyschromatopsia (HP:0007641)1.34277518
150Deformed sella turcica (HP:0002681)1.34149530
151Poor coordination (HP:0002370)1.33963063
152Aplasia/Hypoplasia of the lens (HP:0008063)1.29124865
153Sloping forehead (HP:0000340)1.27978331
154Abnormal gallbladder physiology (HP:0012438)1.27117201
155Cholecystitis (HP:0001082)1.27117201
156Truncal obesity (HP:0001956)1.25476760
157Nephrogenic diabetes insipidus (HP:0009806)1.24506995
158Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.23199985
159Atrophy/Degeneration involving motor neurons (HP:0007373)1.22785291
160Cerebellar dysplasia (HP:0007033)1.20397041
161Papillary thyroid carcinoma (HP:0002895)1.20262528
162Nephroblastoma (Wilms tumor) (HP:0002667)1.20209362
163Broad distal phalanx of finger (HP:0009836)1.19830408
164Ectopic kidney (HP:0000086)1.18840035
165Nephropathy (HP:0000112)1.17975962

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.69021235
2PDK38.69021235
3PDK25.59704982
4TESK14.69405741
5PRKD34.18340513
6CDK194.09959901
7ICK3.53070369
8MET2.96075087
9MAP3K92.91751092
10PTK2B2.27590519
11INSRR2.27362423
12NEK22.24393473
13WNK42.09950008
14ZAK2.05810980
15PNCK2.01512134
16STK391.97181262
17OXSR11.81050941
18CDC71.72882806
19MAP3K131.64777657
20STK381.42196391
21ARAF1.42087130
22FRK1.36712861
23CDK121.30559822
24ADRBK21.25375741
25TRIM281.23766705
26MST1R1.19928399
27PLK21.15335726
28TAOK31.14620037
29NTRK31.14329011
30TTK1.12281243
31WEE11.08515733
32TYRO31.06737794
33STK31.05572357
34STK161.04633679
35TLK11.02270473
36ACVR1B1.01312190
37CDK81.00438795
38NUAK11.00333310
39STK241.00031852
40DYRK1B0.98603707
41VRK10.93502562
42WNK10.93269141
43PASK0.90780325
44DYRK30.90572662
45KSR10.89279779
46CCNB10.88961918
47NEK90.87562370
48KSR20.87418374
49PDK10.87142602
50GRK10.86183858
51NEK10.85843178
52STK38L0.85196262
53PRKCI0.83897889
54MST40.81734962
55PLK40.81646122
56CHEK20.80564668
57EIF2AK30.77891832
58CHEK10.75456210
59ATR0.74772399
60PBK0.73545110
61MAPK150.69624064
62CASK0.66873839
63CSF1R0.66315570
64TIE10.64657438
65MAPK130.61876800
66PLK10.61198441
67IRAK10.60569299
68MAP3K20.58960255
69MAP4K20.58870635
70ATM0.56867758
71PINK10.53261002
72RAF10.52602703
73EEF2K0.51901827
74TGFBR10.51281491
75BRSK20.50829875
76MKNK20.49240738
77CSNK1G10.46369485
78PRKG10.44306840
79CAMK1G0.43911904
80LMTK20.43016629
81CAMK10.40893540
82MTOR0.40567493
83MOS0.39963309
84TESK20.37146665
85MAP3K40.34119396
86BUB10.33522909
87PDPK10.33326969
88PKN10.33124440
89IGF1R0.32320206
90EGFR0.31255070
91TSSK60.31103290
92CSNK1G20.30327450
93BMX0.30216174
94PAK10.30192129
95EPHA40.29168222
96BMPR1B0.27755371
97BRSK10.26949859
98WNK30.24268907
99PRKAA10.23742367
100BRAF0.22555882
101CDK20.22335690
102MUSK0.22247810
103RPS6KB10.22107757
104NTRK20.21165220
105MAP2K60.20416655
106CDK10.19957080
107IRAK20.16567941
108CDK40.16047724
109AURKB0.14897942
110MARK30.14553280
111PAK20.14246047
112PAK40.14244110
113CDK70.13861893
114PRKCG0.13512944
115AURKA0.12341573
116GSK3B0.11813569
117CSNK1D0.11659231
118CSNK2A10.11613222
119PRKDC0.10848795
120BRD40.09965509
121CSNK2A20.09280233
122STK110.08600441
123MAPK80.08438506
124SRPK10.07433116
125RPS6KA10.07383342
126MAP3K100.06263038
127CDK90.06064089
128LATS10.04812502
129MARK20.04754496
130NEK60.04000244
131PLK30.03986767
132RIPK40.03864821
133EIF2AK10.03644037
134PRKCZ0.03259601
135PIM10.03221056
136PDGFRB0.02914092
137CDK30.02606470
138CAMKK10.02584086
139TAOK10.02551358
140MELK0.02438209
141STK100.02176613
142MAPK100.01825735
143CSNK1E0.00362154
144MAPKAPK50.00183395
145MAPK14-0.0134396
146CDK6-0.0119481
147RPS6KA3-0.0108598
148CDK15-0.0060236
149PRKACB-0.0025720
150MAPK1-0.0008117

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.50228634
2Basal transcription factors_Homo sapiens_hsa030224.07700879
3Pyruvate metabolism_Homo sapiens_hsa006203.70750992
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.67105014
5Fatty acid biosynthesis_Homo sapiens_hsa000613.13120993
6Fanconi anemia pathway_Homo sapiens_hsa034602.95597685
7Dorso-ventral axis formation_Homo sapiens_hsa043202.77759555
8Selenocompound metabolism_Homo sapiens_hsa004502.73982123
9Propanoate metabolism_Homo sapiens_hsa006402.69734392
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.59548160
11Linoleic acid metabolism_Homo sapiens_hsa005912.54667735
12Glucagon signaling pathway_Homo sapiens_hsa049222.51904204
13Oocyte meiosis_Homo sapiens_hsa041142.39212818
14Pentose phosphate pathway_Homo sapiens_hsa000302.29434017
15RNA transport_Homo sapiens_hsa030132.28632741
16mRNA surveillance pathway_Homo sapiens_hsa030152.11136061
17RNA polymerase_Homo sapiens_hsa030202.03032609
18Phototransduction_Homo sapiens_hsa047441.89801512
19Glycerolipid metabolism_Homo sapiens_hsa005611.85212776
20Regulation of autophagy_Homo sapiens_hsa041401.79922400
21Caffeine metabolism_Homo sapiens_hsa002321.73218786
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73020814
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.72569953
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70937710
25Homologous recombination_Homo sapiens_hsa034401.66312550
26Ribosome_Homo sapiens_hsa030101.63553130
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.60890462
28Folate biosynthesis_Homo sapiens_hsa007901.57868562
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.56165472
30Olfactory transduction_Homo sapiens_hsa047401.51187094
31Huntingtons disease_Homo sapiens_hsa050161.49960818
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.49798387
33Glycerophospholipid metabolism_Homo sapiens_hsa005641.41999528
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.41366296
35Cell cycle_Homo sapiens_hsa041101.39627604
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37469325
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.29309454
38PPAR signaling pathway_Homo sapiens_hsa033201.23912720
39Purine metabolism_Homo sapiens_hsa002301.23078208
40Nicotine addiction_Homo sapiens_hsa050331.21656094
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20926679
42Carbon metabolism_Homo sapiens_hsa012001.19534956
43Amphetamine addiction_Homo sapiens_hsa050311.17647056
44Parkinsons disease_Homo sapiens_hsa050121.15516108
45Circadian rhythm_Homo sapiens_hsa047101.15111236
46Ether lipid metabolism_Homo sapiens_hsa005651.14138600
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14123017
48DNA replication_Homo sapiens_hsa030301.13307318
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12946787
50Ovarian steroidogenesis_Homo sapiens_hsa049131.12437820
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.12261453
52Antigen processing and presentation_Homo sapiens_hsa046121.11467065
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10767120
54RNA degradation_Homo sapiens_hsa030181.08670794
55Butanoate metabolism_Homo sapiens_hsa006501.08153227
56Fat digestion and absorption_Homo sapiens_hsa049751.07894696
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04499792
58Sulfur relay system_Homo sapiens_hsa041221.04439650
59Fructose and mannose metabolism_Homo sapiens_hsa000511.02119149
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.94477800
61Biosynthesis of amino acids_Homo sapiens_hsa012300.92787503
62Protein export_Homo sapiens_hsa030600.92642857
63Nitrogen metabolism_Homo sapiens_hsa009100.88754005
64Oxidative phosphorylation_Homo sapiens_hsa001900.88250053
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86607932
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86197298
67Renin secretion_Homo sapiens_hsa049240.83886332
68Non-homologous end-joining_Homo sapiens_hsa034500.83396292
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83049859
70Mineral absorption_Homo sapiens_hsa049780.82704131
71Cardiac muscle contraction_Homo sapiens_hsa042600.81991075
72Fatty acid elongation_Homo sapiens_hsa000620.81529712
73Spliceosome_Homo sapiens_hsa030400.81432916
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80782899
75Pyrimidine metabolism_Homo sapiens_hsa002400.78503442
76Nucleotide excision repair_Homo sapiens_hsa034200.78377854
77Fatty acid metabolism_Homo sapiens_hsa012120.78219886
78Retinol metabolism_Homo sapiens_hsa008300.77542083
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75458121
80One carbon pool by folate_Homo sapiens_hsa006700.75130722
81Taste transduction_Homo sapiens_hsa047420.74902683
82Mismatch repair_Homo sapiens_hsa034300.72638322
83Proteasome_Homo sapiens_hsa030500.69543986
84Long-term potentiation_Homo sapiens_hsa047200.67374212
85Base excision repair_Homo sapiens_hsa034100.67270836
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65733106
87Glutathione metabolism_Homo sapiens_hsa004800.64968820
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.64811507
89Systemic lupus erythematosus_Homo sapiens_hsa053220.63537222
90Fatty acid degradation_Homo sapiens_hsa000710.62765832
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.62688368
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.62648469
93Hedgehog signaling pathway_Homo sapiens_hsa043400.61721719
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61472677
95beta-Alanine metabolism_Homo sapiens_hsa004100.58694641
96TGF-beta signaling pathway_Homo sapiens_hsa043500.57727739
97Estrogen signaling pathway_Homo sapiens_hsa049150.56198726
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55732734
99Peroxisome_Homo sapiens_hsa041460.53569676
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53109118
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52873327
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.52842474
103Arachidonic acid metabolism_Homo sapiens_hsa005900.52733113
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52721108
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52641761
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52213108
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49706332
108ABC transporters_Homo sapiens_hsa020100.48391274
109Morphine addiction_Homo sapiens_hsa050320.46597830
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45468597
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45123461
112Epstein-Barr virus infection_Homo sapiens_hsa051690.44236918
113VEGF signaling pathway_Homo sapiens_hsa043700.43657513
114Viral carcinogenesis_Homo sapiens_hsa052030.43160562
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42596588
116Arginine and proline metabolism_Homo sapiens_hsa003300.42501633
117Steroid biosynthesis_Homo sapiens_hsa001000.42195423
118AMPK signaling pathway_Homo sapiens_hsa041520.42102840
119Chemical carcinogenesis_Homo sapiens_hsa052040.41870852
120Renin-angiotensin system_Homo sapiens_hsa046140.41402106
121Inositol phosphate metabolism_Homo sapiens_hsa005620.40809162
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40791122
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40464343
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39106872
125Legionellosis_Homo sapiens_hsa051340.38974303
126p53 signaling pathway_Homo sapiens_hsa041150.36594044
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.35638926
128Tryptophan metabolism_Homo sapiens_hsa003800.35202211
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34840966
130Serotonergic synapse_Homo sapiens_hsa047260.33847549
131Calcium signaling pathway_Homo sapiens_hsa040200.32997034
132Endocytosis_Homo sapiens_hsa041440.32378473
133Metabolic pathways_Homo sapiens_hsa011000.28511388
134N-Glycan biosynthesis_Homo sapiens_hsa005100.27804861
135HTLV-I infection_Homo sapiens_hsa051660.27246613
136Vitamin digestion and absorption_Homo sapiens_hsa049770.25469394
137Wnt signaling pathway_Homo sapiens_hsa043100.24112218
138Herpes simplex infection_Homo sapiens_hsa051680.23970897
139Alcoholism_Homo sapiens_hsa050340.23807734
140Insulin secretion_Homo sapiens_hsa049110.23088965
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21595324
142Influenza A_Homo sapiens_hsa051640.20412974
143Thyroid hormone synthesis_Homo sapiens_hsa049180.20242010
144Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19132821
145Collecting duct acid secretion_Homo sapiens_hsa049660.18521234
146Alzheimers disease_Homo sapiens_hsa050100.18472374
147Vascular smooth muscle contraction_Homo sapiens_hsa042700.18194123
148Lysine degradation_Homo sapiens_hsa003100.15941759
149Synaptic vesicle cycle_Homo sapiens_hsa047210.15933523
150Protein digestion and absorption_Homo sapiens_hsa049740.15289666
151Bile secretion_Homo sapiens_hsa049760.12975106
152Basal cell carcinoma_Homo sapiens_hsa052170.12789325
153GABAergic synapse_Homo sapiens_hsa047270.12139045
154Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.09905169

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