MAF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)5.45910131
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.81060023
3microglial cell activation (GO:0001774)4.56314638
4regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.55510198
5positive regulation by symbiont of host defense response (GO:0052509)4.51645539
6modulation by symbiont of host defense response (GO:0052031)4.51645539
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.51645539
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.51645539
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.51645539
10modulation by symbiont of host immune response (GO:0052553)4.51645539
11positive regulation of monocyte chemotaxis (GO:0090026)4.16213067
12adhesion of symbiont to host cell (GO:0044650)4.13178159
13virion attachment to host cell (GO:0019062)4.13178159
14macrophage activation involved in immune response (GO:0002281)4.07296177
15regulation of interferon-beta biosynthetic process (GO:0045357)4.05390586
16regulation of interferon-alpha production (GO:0032647)3.85132081
17positive regulation of cellular amide metabolic process (GO:0034250)3.82442675
18regulation of B cell receptor signaling pathway (GO:0050855)3.78837135
19neutrophil activation involved in immune response (GO:0002283)3.75598633
20macrophage activation (GO:0042116)3.70821463
21adhesion of symbiont to host (GO:0044406)3.67439935
22positive regulation of interferon-alpha production (GO:0032727)3.58284810
23G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.51585406
24epoxygenase P450 pathway (GO:0019373)3.41441078
25pinocytosis (GO:0006907)3.38995266
26regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.38142130
27regulation of monocyte chemotaxis (GO:0090025)3.35689257
28positive regulation of antigen processing and presentation (GO:0002579)3.32685689
29lipoprotein transport (GO:0042953)3.30331545
30regulation of guanylate cyclase activity (GO:0031282)3.30130501
31phospholipid efflux (GO:0033700)3.25859748
32fat-soluble vitamin biosynthetic process (GO:0042362)3.25313765
33negative regulation of granulocyte differentiation (GO:0030853)3.25145552
34regulation of mononuclear cell migration (GO:0071675)3.21639708
35positive regulation of macrophage differentiation (GO:0045651)3.19853321
36regulation of MHC class II biosynthetic process (GO:0045346)3.18069857
37regulation of macrophage chemotaxis (GO:0010758)3.15647119
38peptide catabolic process (GO:0043171)3.14745201
39negative regulation of mast cell activation (GO:0033004)3.11267910
40phagocytosis, engulfment (GO:0006911)3.10403292
41regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.09595100
42positive regulation of chemokine secretion (GO:0090197)3.08712384
43detection of molecule of bacterial origin (GO:0032490)3.06534952
44fructose metabolic process (GO:0006000)3.04229470
45I-kappaB phosphorylation (GO:0007252)3.00488851
46eosinophil chemotaxis (GO:0048245)2.99296821
47response to host immune response (GO:0052572)2.95586778
48response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.95586778
49antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.92234582
50regulation of chemokine-mediated signaling pathway (GO:0070099)2.92051625
51antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.91661789
52positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.90851200
53response to peptidoglycan (GO:0032494)2.90492692
54positive regulation of calcium-mediated signaling (GO:0050850)2.88587810
55myeloid cell activation involved in immune response (GO:0002275)2.85595520
56developmental pigmentation (GO:0048066)2.85411525
57positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.85196828
58positive regulation of smooth muscle cell migration (GO:0014911)2.85149686
59regulation of triglyceride catabolic process (GO:0010896)2.83955419
60NADH metabolic process (GO:0006734)2.83071280
61negative regulation of B cell proliferation (GO:0030889)2.81789747
62regulation of antigen processing and presentation (GO:0002577)2.80244951
63regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.78313813
64endocrine process (GO:0050886)2.78313813
65regulation of systemic arterial blood pressure by hormone (GO:0001990)2.78313813
66activated T cell proliferation (GO:0050798)2.77547920
67purinergic nucleotide receptor signaling pathway (GO:0035590)2.73769775
68response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.68677901
69response to host (GO:0075136)2.68677901
70response to host defenses (GO:0052200)2.68677901
71dendritic cell migration (GO:0036336)2.68286966
72dendritic cell chemotaxis (GO:0002407)2.66695704
73respiratory burst (GO:0045730)2.65646351
74monocyte chemotaxis (GO:0002548)2.64816792
75oligosaccharide catabolic process (GO:0009313)2.64611803
76cytidine deamination (GO:0009972)2.64529581
77cytidine metabolic process (GO:0046087)2.64529581
78cytidine catabolic process (GO:0006216)2.64529581
79intestinal epithelial cell development (GO:0060576)2.62336884
80regulation of regulatory T cell differentiation (GO:0045589)2.62215816
81positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.62040516
82positive regulation of lymphocyte migration (GO:2000403)2.62028044
83regulation of cellular extravasation (GO:0002691)2.61265422
84regulation of cholesterol esterification (GO:0010872)2.59398673
85regulation of dendritic cell antigen processing and presentation (GO:0002604)2.59280558
86cellular extravasation (GO:0045123)2.59264891
87hormone catabolic process (GO:0042447)2.58016347
88antigen processing and presentation of endogenous antigen (GO:0019883)2.56783512
89eosinophil migration (GO:0072677)2.56608462
90drug metabolic process (GO:0017144)2.56214261
91peptide hormone processing (GO:0016486)2.55914848
92regulation of systemic arterial blood pressure (GO:0003073)2.54135614
93positive regulation of cAMP-mediated signaling (GO:0043950)2.53976896
94tolerance induction (GO:0002507)2.53852745
95regulation of macrophage derived foam cell differentiation (GO:0010743)2.53764741
96granulocyte activation (GO:0036230)2.52482688
97regulation of T cell tolerance induction (GO:0002664)2.52023168
98macroautophagy (GO:0016236)2.51573261
99cellular response to ethanol (GO:0071361)2.50602482
100positive regulation of guanylate cyclase activity (GO:0031284)2.50342484
101renal system process involved in regulation of blood volume (GO:0001977)2.49972271
102negative regulation of interleukin-12 production (GO:0032695)2.49271638
103lymphocyte chemotaxis (GO:0048247)2.48235190
104regulation of cholesterol storage (GO:0010885)2.47612476
105T cell migration (GO:0072678)2.46874586
106negative T cell selection (GO:0043383)2.46725586
107T-helper cell differentiation (GO:0042093)2.45639098
108CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.45639098
109positive regulation of T cell migration (GO:2000406)2.45543004
110negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.44799317
111regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.43394135
112immunoglobulin mediated immune response (GO:0016064)2.41944121
113positive regulation of cholesterol efflux (GO:0010875)2.41654347
114pyrimidine ribonucleoside catabolic process (GO:0046133)2.41055498
115regulation of chemokine secretion (GO:0090196)2.39926099
116intestinal absorption (GO:0050892)2.39695059
117neutrophil activation (GO:0042119)2.39263647
118complement activation, classical pathway (GO:0006958)2.38959211
119regulation of calcium-mediated signaling (GO:0050848)2.38840816
120phospholipid homeostasis (GO:0055091)2.38276055
121low-density lipoprotein particle remodeling (GO:0034374)2.37399227
122regulation of protein glycosylation (GO:0060049)2.35867442
123regulation of lymphocyte chemotaxis (GO:1901623)2.34898056
124myeloid leukocyte activation (GO:0002274)2.34718152
125phenylpropanoid metabolic process (GO:0009698)2.34544079
126regulation of isotype switching to IgG isotypes (GO:0048302)2.33837110
127triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.33375018
128regulation of bile acid biosynthetic process (GO:0070857)2.33284584
129negative thymic T cell selection (GO:0045060)2.32196090
130positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.31767040
131lipopolysaccharide-mediated signaling pathway (GO:0031663)2.31276796
132regulation of cGMP biosynthetic process (GO:0030826)2.31267924
133positive regulation of glycoprotein biosynthetic process (GO:0010560)2.30801051
134positive T cell selection (GO:0043368)2.29623506
135toxin transport (GO:1901998)2.29567240
136regulation of interleukin-8 biosynthetic process (GO:0045414)2.29232530
137response to nitric oxide (GO:0071731)2.26732036
138positive regulation of heat generation (GO:0031652)2.26307636
139positive regulation of leukocyte chemotaxis (GO:0002690)2.25892204
140reverse cholesterol transport (GO:0043691)2.25493665
141negative regulation of lipid storage (GO:0010888)2.22738052
142protein-lipid complex assembly (GO:0065005)2.22539661
143negative regulation of cell killing (GO:0031342)2.22340430
144negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.22340430
145alpha-beta T cell differentiation involved in immune response (GO:0002293)2.22254909
146alpha-beta T cell activation involved in immune response (GO:0002287)2.22254909
147T cell differentiation involved in immune response (GO:0002292)2.22254909
148regulation of fever generation (GO:0031620)2.22167375
149plasma lipoprotein particle assembly (GO:0034377)2.21305752
150macromolecular complex remodeling (GO:0034367)2.20877958
151plasma lipoprotein particle remodeling (GO:0034369)2.20877958
152protein-lipid complex remodeling (GO:0034368)2.20877958
153positive regulation of cholesterol transport (GO:0032376)2.20456636
154positive regulation of sterol transport (GO:0032373)2.20456636
155high-density lipoprotein particle remodeling (GO:0034375)2.20409366
156negative regulation of bone resorption (GO:0045779)2.20057039
157glomerulus development (GO:0032835)2.20023202
158complement activation (GO:0006956)2.19764723
159keratan sulfate catabolic process (GO:0042340)2.19581795
160regulation of lymphocyte migration (GO:2000401)2.19475450
161lipoprotein metabolic process (GO:0042157)2.19331187
162regulation of macrophage differentiation (GO:0045649)2.18542080
163cholesterol efflux (GO:0033344)2.18540276
164regulation of pigment cell differentiation (GO:0050932)2.13127010
165cellular response to nitric oxide (GO:0071732)2.12894334
166T cell selection (GO:0045058)2.12707118
167cellular response to interleukin-15 (GO:0071350)2.12212150
168positive thymic T cell selection (GO:0045059)2.10666432
169regulation of interleukin-2 biosynthetic process (GO:0045076)2.10489605
170T cell costimulation (GO:0031295)2.09769133
171cellular response to reactive nitrogen species (GO:1902170)2.09681824
172regulation of transforming growth factor beta1 production (GO:0032908)2.09548206
173regulation of gamma-delta T cell differentiation (GO:0045586)2.09191659
174lymphocyte costimulation (GO:0031294)2.07946149
175flavonoid metabolic process (GO:0009812)2.07912812
176fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.07124373
177positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.06508614
178protein-lipid complex subunit organization (GO:0071825)2.04840632
179regulation of cGMP metabolic process (GO:0030823)2.04480423
180cellular glucuronidation (GO:0052695)2.03943724

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.76362304
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.03745382
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.80267556
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.33622048
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.25061533
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.04042194
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.70301353
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.44432365
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.43562987
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.40488899
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39921882
12* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.31330370
13SMAD_19615063_ChIP-ChIP_OVARY_Human1.87906278
14* VDR_24787735_ChIP-Seq_THP-1_Human1.80685427
15CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76695118
16* RUNX_20019798_ChIP-Seq_JUKART_Human1.68408226
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.62787374
18* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55791523
19EGR1_19032775_ChIP-ChIP_M12_Human1.53080461
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52920679
21GATA2_21666600_ChIP-Seq_HMVEC_Human1.49571891
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47601749
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46861892
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46434850
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.40011415
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38345324
27PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34059666
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34051032
29* LXR_22158963_ChIP-Seq_LIVER_Mouse1.28371609
30* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27589362
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.26142720
32* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25748240
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25371255
34PU_27001747_Chip-Seq_BMDM_Mouse1.24851481
35CDX2_20551321_ChIP-Seq_CACO-2_Human1.24770645
36* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21985350
37CJUN_26792858_Chip-Seq_BT549_Human1.21604072
38ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21042278
39GBX2_23144817_ChIP-Seq_PC3_Human1.20391416
40* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18676757
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.18655275
42RXR_22158963_ChIP-Seq_LIVER_Mouse1.14303815
43* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13921364
44* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13399059
45* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11031224
46* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10536868
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.09064358
48* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07981896
49* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07981896
50TCF4_18268006_ChIP-ChIP_LS174T_Human1.07312333
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06238149
52FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05567768
53TAF15_26573619_Chip-Seq_HEK293_Human1.05349416
54* TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04684710
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.04131029
56* SMAD3_21741376_ChIP-Seq_EPCs_Human1.03881557
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03631258
58TP53_18474530_ChIP-ChIP_U2OS_Human1.03607277
59ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03507388
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02865882
61SCL_19346495_ChIP-Seq_HPC-7_Human1.02588412
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02372742
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02023992
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01521915
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.00179015
66EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99970694
67TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99900410
68AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99782184
69FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99533614
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98583791
71AHR_22903824_ChIP-Seq_MCF-7_Human0.97419038
72* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97161579
73PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97143881
74NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96796628
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96072459
76* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96017175
77EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95986465
78* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95415416
79* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95319125
80* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94384100
81NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93540946
82TP53_16413492_ChIP-PET_HCT116_Human0.93435194
83SPI1_23127762_ChIP-Seq_K562_Human0.93117071
84TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92037444
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91789931
86CDX2_22108803_ChIP-Seq_LS180_Human0.91702503
87GATA1_22025678_ChIP-Seq_K562_Human0.91032680
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90588148
89DROSHA_22980978_ChIP-Seq_HELA_Human0.90078965
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90059344
91SOX2_20726797_ChIP-Seq_SW620_Human0.89956918
92IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89745036
93* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89704117
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88723642
95TRIM28_21343339_ChIP-Seq_HEK293_Human0.88718909
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88197150
97* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87397075
98RXR_22108803_ChIP-Seq_LS180_Human0.87295386
99PPARA_22158963_ChIP-Seq_LIVER_Mouse0.87087731
100SMAD4_21799915_ChIP-Seq_A2780_Human0.86749944
101NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86716656
102CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86708731
103SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85700154
104SOX2_27498859_Chip-Seq_STOMACH_Mouse0.85428545
105* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85322140
106* BCAT_22108803_ChIP-Seq_LS180_Human0.84840523
107* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84826430
108EZH2_27294783_Chip-Seq_NPCs_Mouse0.84826367
109* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.84700949
110FLI1_27457419_Chip-Seq_LIVER_Mouse0.83920844
111* GATA2_19941826_ChIP-Seq_K562_Human0.83530740
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83363093
113* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.82543656
114* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.82543656
115* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82449687
116P300_19829295_ChIP-Seq_ESCs_Human0.81829307
117* TP63_23658742_ChIP-Seq_EP156T_Human0.81827512
118PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81660201
119EED_16625203_ChIP-ChIP_MESCs_Mouse0.80949425
120NFE2_27457419_Chip-Seq_LIVER_Mouse0.80697448
121* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.80413494
122* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80308722
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.79861839
124GATA4_25053715_ChIP-Seq_YYC3_Human0.79671840
125PCGF2_27294783_Chip-Seq_NPCs_Mouse0.79615635
126* TCF4_22108803_ChIP-Seq_LS180_Human0.79504565
127* PRDM14_20953172_ChIP-Seq_ESCs_Human0.79333120
128EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.79311042
129EP300_21415370_ChIP-Seq_HL-1_Mouse0.79020193
130* SMAD3_21741376_ChIP-Seq_HESCs_Human0.78765749
131OCT4_21477851_ChIP-Seq_ESCs_Mouse0.78656404
132LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78548605
133AR_21572438_ChIP-Seq_LNCaP_Human0.78051997

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.25218638
2MP0003191_abnormal_cellular_cholesterol3.24458051
3MP0001835_abnormal_antigen_presentation3.23765699
4MP0006082_CNS_inflammation3.18578051
5MP0002148_abnormal_hypersensitivity_rea3.08471420
6MP0003303_peritoneal_inflammation3.08265896
7MP0010234_abnormal_vibrissa_follicle3.06492332
8MP0009840_abnormal_foam_cell2.99935436
9MP0009379_abnormal_foot_pigmentation2.72712984
10MP0003436_decreased_susceptibility_to2.62405576
11MP0005360_urolithiasis2.60765382
12MP0003300_gastrointestinal_ulcer2.56211129
13MP0002419_abnormal_innate_immunity2.46912869
14MP0003724_increased_susceptibility_to2.45112550
15MP0005671_abnormal_response_to2.34407004
16MP0005000_abnormal_immune_tolerance2.24354651
17MP0002009_preneoplasia2.23305825
18MP0001790_abnormal_immune_system2.17968014
19MP0005387_immune_system_phenotype2.17968014
20MP0000343_altered_response_to2.17623926
21MP0008438_abnormal_cutaneous_collagen2.11075391
22MP0002254_reproductive_system_inflammat2.10331663
23MP0001666_abnormal_nutrient_absorption2.08687652
24MP0005365_abnormal_bile_salt2.03376967
25MP0009785_altered_susceptibility_to2.02782635
26MP0001533_abnormal_skeleton_physiology2.01078101
27MP0002998_abnormal_bone_remodeling1.97528381
28MP0002277_abnormal_respiratory_mucosa1.97082415
29MP0005025_abnormal_response_to1.93078322
30MP0005409_darkened_coat_color1.92271600
31MP0002452_abnormal_antigen_presenting1.89675129
32MP0001800_abnormal_humoral_immune1.85418731
33MP0003172_abnormal_lysosome_physiology1.84899939
34MP0000604_amyloidosis1.79990772
35MP0005464_abnormal_platelet_physiology1.74912027
36* MP0002723_abnormal_immune_serum1.70756296
37MP0001501_abnormal_sleep_pattern1.69424130
38MP0003690_abnormal_glial_cell1.69074858
39MP0001188_hyperpigmentation1.67837552
40MP0003252_abnormal_bile_duct1.66500563
41MP0009764_decreased_sensitivity_to1.61633471
42MP0004019_abnormal_vitamin_homeostasis1.61348653
43MP0004510_myositis1.60278148
44MP0004264_abnormal_extraembryonic_tissu1.57526414
45MP0005275_abnormal_skin_tensile1.55870998
46MP0002138_abnormal_hepatobiliary_system1.49584450
47MP0001958_emphysema1.48846075
48MP0002971_abnormal_brown_adipose1.47581249
49MP0002405_respiratory_system_inflammati1.46502507
50MP0001819_abnormal_immune_cell1.45853422
51MP0002796_impaired_skin_barrier1.45158912
52MP0008469_abnormal_protein_level1.44916045
53MP0002420_abnormal_adaptive_immunity1.44004386
54* MP0001845_abnormal_inflammatory_respons1.42089225
55MP0001853_heart_inflammation1.41456591
56MP0003075_altered_response_to1.41247449
57MP0005174_abnormal_tail_pigmentation1.40833510
58MP0002876_abnormal_thyroid_physiology1.39064064
59MP0003866_abnormal_defecation1.38268225
60MP0005310_abnormal_salivary_gland1.34376988
61MP0005166_decreased_susceptibility_to1.33477802
62MP0000538_abnormal_urinary_bladder1.30291378
63MP0000569_abnormal_digit_pigmentation1.29548305
64MP0010155_abnormal_intestine_physiology1.26387211
65MP0004947_skin_inflammation1.25370613
66MP0003448_altered_tumor_morphology1.23373998
67MP0000685_abnormal_immune_system1.22806678
68MP0004782_abnormal_surfactant_physiolog1.21202194
69MP0004270_analgesia1.20907052
70MP0005503_abnormal_tendon_morphology1.20848389
71MP0004043_abnormal_pH_regulation1.20634121
72MP0003279_aneurysm1.19329576
73MP0002933_joint_inflammation1.15753846
74MP0003705_abnormal_hypodermis_morpholog1.12864768
75MP0010678_abnormal_skin_adnexa1.11705153
76MP0005167_abnormal_blood-brain_barrier1.11073875
77MP0003868_abnormal_feces_composition1.08110517
78MP0004147_increased_porphyrin_level1.07059930
79MP0005390_skeleton_phenotype1.06041016
80MP0001542_abnormal_bone_strength1.06031155
81MP0000465_gastrointestinal_hemorrhage1.03053567
82MP0010329_abnormal_lipoprotein_level1.00489360
83MP0003045_fibrosis1.00017740
84MP0001873_stomach_inflammation0.95983950
85MP0003795_abnormal_bone_structure0.95916616
86MP0003828_pulmonary_edema0.93903322
87MP0003195_calcinosis0.93883593
88MP0002139_abnormal_hepatobiliary_system0.91509998
89MP0001756_abnormal_urination0.91407539
90MP0008875_abnormal_xenobiotic_pharmacok0.90445647
91MP0005164_abnormal_response_to0.90021816
92MP0002166_altered_tumor_susceptibility0.87953307
93MP0001765_abnormal_ion_homeostasis0.87886862
94MP0004381_abnormal_hair_follicle0.87631757
95MP0000716_abnormal_immune_system0.87617882
96MP0002136_abnormal_kidney_physiology0.87355635
97MP0001851_eye_inflammation0.86957112
98MP0002332_abnormal_exercise_endurance0.86749613
99MP0002909_abnormal_adrenal_gland0.86667594
100MP0000249_abnormal_blood_vessel0.82316935
101MP0005332_abnormal_amino_acid0.81788981
102MP0005670_abnormal_white_adipose0.81363584
103MP0000230_abnormal_systemic_arterial0.79028193
104MP0004883_abnormal_blood_vessel0.78834110
105MP0004484_altered_response_of0.78515244
106MP0009333_abnormal_splenocyte_physiolog0.78458723
107MP0009763_increased_sensitivity_to0.77469616
108MP0003763_abnormal_thymus_physiology0.77337387
109MP0002896_abnormal_bone_mineralization0.77112702
110MP0003183_abnormal_peptide_metabolism0.76957691
111MP0005085_abnormal_gallbladder_physiolo0.76956014
112MP0000767_abnormal_smooth_muscle0.76589465
113MP0004885_abnormal_endolymph0.74760762
114MP0000609_abnormal_liver_physiology0.74236838
115MP0002060_abnormal_skin_morphology0.74038668
116MP0001664_abnormal_digestion0.73337290
117MP0005535_abnormal_body_temperature0.72811741
118MP0000015_abnormal_ear_pigmentation0.72042194
119MP0005584_abnormal_enzyme/coenzyme_acti0.71935243
120MP0005595_abnormal_vascular_smooth0.71636999
121MP0000462_abnormal_digestive_system0.71531052
122MP0002168_other_aberrant_phenotype0.70607074
123MP0002118_abnormal_lipid_homeostasis0.70224946
124MP0009115_abnormal_fat_cell0.70207324
125* MP0002697_abnormal_eye_size0.70161350
126MP0005451_abnormal_body_composition0.69978463
127MP0000689_abnormal_spleen_morphology0.69635434
128MP0002006_tumorigenesis0.69326989
129MP0002396_abnormal_hematopoietic_system0.68890498
130MP0001663_abnormal_digestive_system0.68697854
131* MP0005193_abnormal_anterior_eye0.67337685
132* MP0005197_abnormal_uvea_morphology0.66476397
133MP0005023_abnormal_wound_healing0.65453596
134* MP0009643_abnormal_urine_homeostasis0.65187913
135MP0005165_increased_susceptibility_to0.64941752
136MP0004130_abnormal_muscle_cell0.64912046

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.43202660
2Glomerulonephritis (HP:0000099)5.94184079
3Complement deficiency (HP:0004431)5.17802356
4Nuclear cataract (HP:0100018)4.68406128
5Recurrent abscess formation (HP:0002722)4.49379392
6Eczematoid dermatitis (HP:0000976)4.42660197
7Recurrent bacterial skin infections (HP:0005406)4.39394025
8Malnutrition (HP:0004395)4.34628744
9Abnormality of complement system (HP:0005339)4.17061001
10* Zonular cataract (HP:0010920)4.15329991
11Vacuolated lymphocytes (HP:0001922)4.01260166
12Thick nail (HP:0001805)3.83345201
13Orchitis (HP:0100796)3.79312391
14Decreased circulating renin level (HP:0003351)3.72404172
15Retrobulbar optic neuritis (HP:0100654)3.69456957
16Optic neuritis (HP:0100653)3.69456957
17Axonal loss (HP:0003447)3.62372999
18Nephritis (HP:0000123)3.59245444
19Amelogenesis imperfecta (HP:0000705)3.44327984
20Myositis (HP:0100614)3.44298402
21Spontaneous hematomas (HP:0007420)3.35097015
22Autoimmune thrombocytopenia (HP:0001973)3.29773772
23Potter facies (HP:0002009)3.24114216
24Facial shape deformation (HP:0011334)3.24114216
25Increased cerebral lipofuscin (HP:0011813)3.17557268
26Prostate neoplasm (HP:0100787)3.17155084
27Joint hemorrhage (HP:0005261)3.11451644
28Increased neuronal autofluorescent lipopigment (HP:0002074)3.11043573
29Recurrent gram-negative bacterial infections (HP:0005420)3.05156202
30Disinhibition (HP:0000734)3.00671952
31Abnormality of T cell number (HP:0011839)2.95043259
32Gingivitis (HP:0000230)2.90160168
33Pustule (HP:0200039)2.84539462
34T lymphocytopenia (HP:0005403)2.83181522
35Abnormality of macrophages (HP:0004311)2.81074039
36Hematochezia (HP:0002573)2.80177903
37Hyperactive renin-angiotensin system (HP:0000841)2.78944922
38Pulmonary infiltrates (HP:0002113)2.75784589
39Myocardial infarction (HP:0001658)2.75614078
40Abnormality of glycolipid metabolism (HP:0010969)2.74896165
41Abnormality of liposaccharide metabolism (HP:0010968)2.74896165
42Abnormality of glycosphingolipid metabolism (HP:0004343)2.74896165
43Widely patent fontanelles and sutures (HP:0004492)2.70910703
44Abnormality of the prostate (HP:0008775)2.68514310
45Dysostosis multiplex (HP:0000943)2.66653242
46Recurrent skin infections (HP:0001581)2.64563237
47Abnormality of vitamin B metabolism (HP:0004340)2.64202743
48Congenital sensorineural hearing impairment (HP:0008527)2.60333927
49Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.59420920
50Abnormality of the vitamin B12 metabolism (HP:0004341)2.56540287
51Chronic obstructive pulmonary disease (HP:0006510)2.55390628
52Obstructive lung disease (HP:0006536)2.55390628
53Chronic diarrhea (HP:0002028)2.54293512
54Keratoconjunctivitis sicca (HP:0001097)2.48770176
55Abnormality of proline metabolism (HP:0010907)2.47848934
56Hydroxyprolinuria (HP:0003080)2.47848934
57Thickened helices (HP:0000391)2.47406859
58Abnormality of glutamine family amino acid metabolism (HP:0010902)2.47142978
59Aplasia cutis congenita (HP:0001057)2.41023174
60Pathologic fracture (HP:0002756)2.39601340
61Arterial tortuosity (HP:0005116)2.33576230
62Abnormality of incisor morphology (HP:0011063)2.31666664
63Increased IgE level (HP:0003212)2.26861261
64Mediastinal lymphadenopathy (HP:0100721)2.26257646
65Keratoconjunctivitis (HP:0001096)2.25407965
66Arterial thrombosis (HP:0004420)2.25068633
67Palmoplantar hyperkeratosis (HP:0000972)2.24953037
68Recurrent fungal infections (HP:0002841)2.24643300
69Bone pain (HP:0002653)2.22929138
70Hemoptysis (HP:0002105)2.22521401
71Eosinophilia (HP:0001880)2.20576774
72Osteolytic defects of the phalanges of the hand (HP:0009771)2.19154022
73Osteolytic defects of the hand bones (HP:0009699)2.19154022
74Protuberant abdomen (HP:0001538)2.18507760
75Hyperkalemia (HP:0002153)2.17956558
76Pulmonary embolism (HP:0002204)2.16033172
77Upper motor neuron abnormality (HP:0002127)2.15186098
78Abnormality of renin-angiotensin system (HP:0000847)2.15119366
79Fat malabsorption (HP:0002630)2.14328939
80Stomatitis (HP:0010280)2.13469343
81Periodontitis (HP:0000704)2.12701801
82Vasculitis (HP:0002633)2.11052228
83Thyroiditis (HP:0100646)2.10342254
84Increased CSF protein (HP:0002922)2.10264613
85Palmar hyperkeratosis (HP:0010765)2.09607392
86Vascular tortuosity (HP:0004948)2.07398056
87Joint swelling (HP:0001386)2.05577574
88Basal ganglia calcification (HP:0002135)2.04585189
89Frequent falls (HP:0002359)2.04117391
90Exercise-induced myalgia (HP:0003738)2.02772923
91Alopecia of scalp (HP:0002293)2.00279168
92Hypobetalipoproteinemia (HP:0003563)1.99932033
93Urethral obstruction (HP:0000796)1.99238090
94Premature loss of primary teeth (HP:0006323)1.97704237
95Retinal atrophy (HP:0001105)1.97372007
96Aortic dissection (HP:0002647)1.95542958
97Xanthomatosis (HP:0000991)1.95235973
98Peripheral demyelination (HP:0011096)1.94244536
99Urinary glycosaminoglycan excretion (HP:0003541)1.94043628
100Mucopolysacchariduria (HP:0008155)1.94043628
101Gangrene (HP:0100758)1.92929433
102Neonatal short-limb short stature (HP:0008921)1.92656806
103* Corneal dystrophy (HP:0001131)1.92077694
104Progressive visual loss (HP:0000529)1.92019611
105Abnormal delayed hypersensitivity skin test (HP:0002963)1.88756699
106Metabolic alkalosis (HP:0200114)1.88130288
107Abnormality of vitamin metabolism (HP:0100508)1.87243605
108Plantar hyperkeratosis (HP:0007556)1.86158343
109Atrophic scars (HP:0001075)1.85996613
110Patchy hypopigmentation of hair (HP:0011365)1.85960276
111Abnormality of polysaccharide metabolism (HP:0011012)1.85916443
112Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85916443
113Abnormality of mucopolysaccharide metabolism (HP:0011020)1.85916443
114Stomach cancer (HP:0012126)1.80802026
115Abnormality of the lumbar spine (HP:0100712)1.80619241
116Arthropathy (HP:0003040)1.80520353
117Conjunctival hamartoma (HP:0100780)1.80284304
118Hypokalemia (HP:0002900)1.79830209
119Abnormality of T cells (HP:0002843)1.79046366
120Inflammation of the large intestine (HP:0002037)1.78868285
121Bone cyst (HP:0012062)1.78856649
122Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.78727253
123Conical tooth (HP:0000698)1.78543298
124Agnosia (HP:0010524)1.78451038
125Meningitis (HP:0001287)1.78180030
126Hypotension (HP:0002615)1.77297484
127Epistaxis (HP:0000421)1.77249648
128Leukocytosis (HP:0001974)1.76564108
129Hyperventilation (HP:0002883)1.76120430
130Osteomyelitis (HP:0002754)1.75386803
131Abdominal distention (HP:0003270)1.74649005
132Gingival bleeding (HP:0000225)1.74645438
133Epidermoid cyst (HP:0200040)1.74362120
134Glomerulopathy (HP:0100820)1.73953383
135Thrombophlebitis (HP:0004418)1.73615576
136Confusion (HP:0001289)1.73584120
137Abnormality of secondary sexual hair (HP:0009888)1.73008540
138Abnormality of the axillary hair (HP:0100134)1.73008540
139Milia (HP:0001056)1.72902390
140Chest pain (HP:0100749)1.72767993
141Abnormality of the pericardium (HP:0001697)1.72615934
142Acanthocytosis (HP:0001927)1.71849306
143Alkalosis (HP:0001948)1.71629132
144Steatorrhea (HP:0002570)1.70432547
145Abnormality of potassium homeostasis (HP:0011042)1.70407590
146Spondylolisthesis (HP:0003302)1.70302290
147Asymmetric septal hypertrophy (HP:0001670)1.70120533
148White forelock (HP:0002211)1.69701836
149Mutism (HP:0002300)1.68703752
150Proximal tubulopathy (HP:0000114)1.68582493
151Hypotrichosis (HP:0001006)1.68537681
152Abnormality of the costochondral junction (HP:0000919)1.66520917
153Autoimmune hemolytic anemia (HP:0001890)1.65132294
154Segmental peripheral demyelination/remyelination (HP:0003481)1.63362433
155Recurrent bronchitis (HP:0002837)1.61474519
156Recurrent cutaneous fungal infections (HP:0011370)1.60632046

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.91657357
2ACVR1B4.46924603
3TGFBR24.30747675
4BLK3.74937040
5MAP3K143.71186342
6TYK23.09111188
7GRK72.66872325
8MST42.61753369
9NEK92.43577556
10IRAK32.32924605
11EPHA32.04995398
12TNIK1.99866252
13JAK11.97504509
14IRAK41.89417878
15STK241.84407867
16RIPK11.82509697
17FGFR21.76022822
18TBK11.69749969
19IKBKE1.60814259
20OBSCN1.57893763
21NLK1.57782936
22MAP3K131.41431483
23PIK3CG1.37781340
24KIT1.34063453
25CSF1R1.33256268
26MAP4K11.32722937
27JAK31.32651641
28IKBKB1.26788861
29STK101.26568652
30ZAP701.25900198
31HCK1.24849797
32NUAK11.21894100
33JAK21.21608974
34FGFR41.17724745
35MAPKAPK31.10724757
36FGFR31.09297770
37MAP3K101.09238073
38RIPK41.08691417
39CLK11.07062538
40ITK1.05344370
41LCK1.05286385
42EPHB11.04120413
43AKT31.03519542
44YES10.98928886
45GRK60.97492824
46CSK0.97197708
47MAP2K60.96854166
48PIM20.96756192
49PINK10.95431357
50CAMK1G0.93953905
51BMPR20.92902412
52DMPK0.92873683
53ERN10.92583330
54LYN0.91314216
55CDK60.91107577
56PRPF4B0.90719587
57STK390.89859046
58SGK2230.88553825
59SGK4940.88553825
60CHUK0.88042586
61CAMKK20.87476931
62TNK20.84910491
63OXSR10.84766447
64MAP3K20.82442493
65FES0.81801300
66EIF2AK20.81678149
67MST1R0.80392943
68MAPK120.79652880
69MAPK110.79035330
70SYK0.78992796
71CAMK1D0.78603084
72MARK10.77870711
73IGF1R0.76536083
74TAOK30.74888697
75TTN0.72563897
76BTK0.72023324
77PHKG10.69116799
78PHKG20.69116799
79TEC0.68074886
80CASK0.67036645
81ERBB20.66972558
82TYRO30.65914774
83MAP3K70.65485691
84NTRK10.65340637
85TGFBR10.64611330
86TRPM70.64022074
87SIK30.62945010
88ADRBK20.62484487
89SGK30.61915313
90PKN10.60910540
91SGK20.59238478
92PRKCQ0.58975203
93MAP3K10.57241330
94MATK0.57100709
95MAPK70.56157364
96MOS0.55840924
97RPS6KA20.55211570
98PDK20.54944453
99PDK10.54759420
100FGR0.54029917
101LATS10.53502257
102PDGFRB0.53327258
103PRKG10.53278189
104WNK30.52642997
105MAPK130.52167781
106GRK50.51670986
107PBK0.51618920
108IRAK10.51277966
109NTRK20.51260117
110MAP3K30.50808231
111BMPR1B0.50493913
112RPS6KC10.50223852
113RPS6KL10.50223852
114BMX0.50085501
115PRKG20.49348007
116BCR0.48930880
117RPS6KA60.48763466
118ERBB30.48583152
119CDK30.48156382
120PRKCE0.47821867
121PTK60.47277926
122PRKCD0.46837512
123EPHA40.46718908
124FGFR10.46606420
125INSR0.46522340
126STK30.46070460
127FYN0.46052485
128PIM10.45483667
129PRKAA20.44893425
130MAPKAPK20.44468317
131PIK3CA0.43403503
132GSK3A0.43263769
133FER0.43073335
134RPS6KB10.42951875
135PRKACG0.42391607
136RET0.42114407
137WNK10.41094363
138FRK0.40604483
139SGK10.40466003
140ROCK10.40421521
141EGFR0.40163244
142STK110.39909813
143MARK30.39881894
144EPHB20.39221442
145CDK80.39137299
146ABL10.38313685

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051505.01214833
2Cyanoamino acid metabolism_Homo sapiens_hsa004602.35693009
3Other glycan degradation_Homo sapiens_hsa005112.23481189
4Leishmaniasis_Homo sapiens_hsa051402.22592427
5Lysosome_Homo sapiens_hsa041422.20344453
6Complement and coagulation cascades_Homo sapiens_hsa046102.10780892
7Glycosaminoglycan degradation_Homo sapiens_hsa005311.99602918
8Osteoclast differentiation_Homo sapiens_hsa043801.99157727
9* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.98967311
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.97287538
11Autoimmune thyroid disease_Homo sapiens_hsa053201.86388485
12Pertussis_Homo sapiens_hsa051331.84611870
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.82909453
14Allograft rejection_Homo sapiens_hsa053301.76449082
15Asthma_Homo sapiens_hsa053101.75792802
16Linoleic acid metabolism_Homo sapiens_hsa005911.64157047
17Rheumatoid arthritis_Homo sapiens_hsa053231.64039252
18Tuberculosis_Homo sapiens_hsa051521.63891606
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.57814464
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55534929
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.53991722
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.51127632
23Measles_Homo sapiens_hsa051621.50194686
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48087417
25Mineral absorption_Homo sapiens_hsa049781.45491375
26Phagosome_Homo sapiens_hsa041451.42254844
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.41618356
28Malaria_Homo sapiens_hsa051441.36814095
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.35300651
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33074707
31Toxoplasmosis_Homo sapiens_hsa051451.32985018
32Chemokine signaling pathway_Homo sapiens_hsa040621.17507217
33Hematopoietic cell lineage_Homo sapiens_hsa046401.16851011
34Starch and sucrose metabolism_Homo sapiens_hsa005001.14426476
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13903849
36Salmonella infection_Homo sapiens_hsa051321.12961274
37Caffeine metabolism_Homo sapiens_hsa002321.12947362
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12509511
39Legionellosis_Homo sapiens_hsa051341.12357450
40Graft-versus-host disease_Homo sapiens_hsa053321.09449090
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.07227467
42Ether lipid metabolism_Homo sapiens_hsa005650.97647152
43Primary immunodeficiency_Homo sapiens_hsa053400.96734803
44Prion diseases_Homo sapiens_hsa050200.96260236
45Circadian rhythm_Homo sapiens_hsa047100.95833253
46Influenza A_Homo sapiens_hsa051640.94694763
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94048605
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93884574
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90905801
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89493661
51NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89206205
52Renin-angiotensin system_Homo sapiens_hsa046140.89161462
53B cell receptor signaling pathway_Homo sapiens_hsa046620.87455968
54T cell receptor signaling pathway_Homo sapiens_hsa046600.86333299
55Amoebiasis_Homo sapiens_hsa051460.84978270
56Vitamin digestion and absorption_Homo sapiens_hsa049770.84762339
57Glycerolipid metabolism_Homo sapiens_hsa005610.82576476
58Antigen processing and presentation_Homo sapiens_hsa046120.82339765
59Dorso-ventral axis formation_Homo sapiens_hsa043200.81056718
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.79941062
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.78972920
62Fructose and mannose metabolism_Homo sapiens_hsa000510.78223532
63ABC transporters_Homo sapiens_hsa020100.74842960
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73435983
65PPAR signaling pathway_Homo sapiens_hsa033200.72553056
66Sphingolipid metabolism_Homo sapiens_hsa006000.72463219
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71706260
68Galactose metabolism_Homo sapiens_hsa000520.69901265
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.68934082
70TNF signaling pathway_Homo sapiens_hsa046680.67929617
71Arginine biosynthesis_Homo sapiens_hsa002200.66991078
72Arginine and proline metabolism_Homo sapiens_hsa003300.66285777
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65626338
74Retinol metabolism_Homo sapiens_hsa008300.65371881
75Arachidonic acid metabolism_Homo sapiens_hsa005900.65244047
76Fatty acid degradation_Homo sapiens_hsa000710.64892734
77Hepatitis C_Homo sapiens_hsa051600.64654975
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64448968
79beta-Alanine metabolism_Homo sapiens_hsa004100.64360202
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64219091
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64189039
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64135168
83African trypanosomiasis_Homo sapiens_hsa051430.64033085
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63893927
85Pancreatic secretion_Homo sapiens_hsa049720.63243522
86Viral myocarditis_Homo sapiens_hsa054160.60322820
87Insulin resistance_Homo sapiens_hsa049310.59249567
88Histidine metabolism_Homo sapiens_hsa003400.58682604
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58461605
90Nitrogen metabolism_Homo sapiens_hsa009100.57727760
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57512238
92Fat digestion and absorption_Homo sapiens_hsa049750.57030672
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.56424091
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.55769936
95ECM-receptor interaction_Homo sapiens_hsa045120.55458827
96Protein digestion and absorption_Homo sapiens_hsa049740.55259332
97Chemical carcinogenesis_Homo sapiens_hsa052040.54550573
98Pancreatic cancer_Homo sapiens_hsa052120.53020719
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52452191
100Platelet activation_Homo sapiens_hsa046110.52242217
101Apoptosis_Homo sapiens_hsa042100.52190994
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51944375
103GnRH signaling pathway_Homo sapiens_hsa049120.51263236
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50631157
105Peroxisome_Homo sapiens_hsa041460.50426453
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50335228
107Collecting duct acid secretion_Homo sapiens_hsa049660.50158663
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.50066737
109Endocytosis_Homo sapiens_hsa041440.49197556
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47306862
111Ovarian steroidogenesis_Homo sapiens_hsa049130.47232690
112Long-term potentiation_Homo sapiens_hsa047200.47146948
113Gastric acid secretion_Homo sapiens_hsa049710.46880692
114Insulin secretion_Homo sapiens_hsa049110.44950329
115Adherens junction_Homo sapiens_hsa045200.44845193
116Hepatitis B_Homo sapiens_hsa051610.44248221
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.42668211
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41481811
119Serotonergic synapse_Homo sapiens_hsa047260.38271044
120FoxO signaling pathway_Homo sapiens_hsa040680.37998312
121Focal adhesion_Homo sapiens_hsa045100.37142807
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36884085
123Herpes simplex infection_Homo sapiens_hsa051680.36468557
124Amphetamine addiction_Homo sapiens_hsa050310.36104722
125Long-term depression_Homo sapiens_hsa047300.35692350
126Shigellosis_Homo sapiens_hsa051310.34534897
127Bile secretion_Homo sapiens_hsa049760.34490668
128Type I diabetes mellitus_Homo sapiens_hsa049400.33525011
129Chronic myeloid leukemia_Homo sapiens_hsa052200.33246942
130Tryptophan metabolism_Homo sapiens_hsa003800.33203928
131Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33114748
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32769539
133Renin secretion_Homo sapiens_hsa049240.32270051
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31684472

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