MAF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.79637972
2DNA deamination (GO:0045006)5.91378110
3viral transcription (GO:0019083)5.70405102
4translational termination (GO:0006415)5.41461634
5translational elongation (GO:0006414)4.93127462
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.92280988
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.92280988
8positive regulation of gamma-delta T cell activation (GO:0046645)4.68310414
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.65794948
10antigen processing and presentation via MHC class Ib (GO:0002475)4.63743678
11protein targeting to ER (GO:0045047)4.55434022
12cotranslational protein targeting to membrane (GO:0006613)4.50377784
13viral life cycle (GO:0019058)4.39496992
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.33898734
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.32041149
16protein localization to endoplasmic reticulum (GO:0070972)4.30929689
17ribosomal small subunit biogenesis (GO:0042274)4.21368158
18antigen processing and presentation of endogenous antigen (GO:0019883)4.21046190
19negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.17684934
20cellular protein complex disassembly (GO:0043624)4.14684032
21translational initiation (GO:0006413)4.13239369
22regulation of gamma-delta T cell differentiation (GO:0045586)4.03539236
23Golgi transport vesicle coating (GO:0048200)3.99622044
24COPI coating of Golgi vesicle (GO:0048205)3.99622044
25negative regulation of erythrocyte differentiation (GO:0045647)3.98615473
26protein complex disassembly (GO:0043241)3.88815128
27maturation of SSU-rRNA (GO:0030490)3.87109250
28negative regulation of cell size (GO:0045792)3.83864051
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.80616659
30deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.78815740
31negative regulation of necroptotic process (GO:0060546)3.71635358
32cellular response to zinc ion (GO:0071294)3.65564563
33NADH metabolic process (GO:0006734)3.65056843
34macromolecular complex disassembly (GO:0032984)3.62348913
35regulation of gamma-delta T cell activation (GO:0046643)3.55683381
36pinocytosis (GO:0006907)3.51480760
37regulation of necrotic cell death (GO:0010939)3.45608550
38formation of translation preinitiation complex (GO:0001731)3.32855519
39negative regulation of necrotic cell death (GO:0060547)3.30444582
40glucose catabolic process (GO:0006007)3.30029697
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.29899241
42nuclear-transcribed mRNA catabolic process (GO:0000956)3.27200345
43protein localization to endosome (GO:0036010)3.25963969
44regulation of necroptotic process (GO:0060544)3.25357114
45DNA strand elongation involved in DNA replication (GO:0006271)3.24886884
46modulation by virus of host process (GO:0019054)3.24664875
47negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.21813977
48positive regulation of B cell differentiation (GO:0045579)3.19611381
49modulation by symbiont of host cellular process (GO:0044068)3.19549124
50negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.17953454
51proline biosynthetic process (GO:0006561)3.16183197
52NADPH regeneration (GO:0006740)3.16065576
53protein retention in ER lumen (GO:0006621)3.15040724
54protein targeting to membrane (GO:0006612)3.13847023
55mRNA catabolic process (GO:0006402)3.13810910
56telomere maintenance via semi-conservative replication (GO:0032201)3.12921051
57DNA unwinding involved in DNA replication (GO:0006268)3.09805002
58retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.08991102
59protein maturation by protein folding (GO:0022417)3.08200649
60DNA strand elongation (GO:0022616)3.07654125
61GDP-mannose metabolic process (GO:0019673)3.04274935
62ribosomal large subunit biogenesis (GO:0042273)3.03900571
63barbed-end actin filament capping (GO:0051016)3.00469387
64RNA catabolic process (GO:0006401)2.96700594
65positive regulation of Cdc42 GTPase activity (GO:0043089)2.95472152
66translation (GO:0006412)2.94032576
67maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.93309721
68cellular hyperosmotic response (GO:0071474)2.91559027
69B cell receptor signaling pathway (GO:0050853)2.89903193
70response to interferon-beta (GO:0035456)2.89095352
71peptidyl-arginine omega-N-methylation (GO:0035247)2.87421488
72regulation of mammary gland epithelial cell proliferation (GO:0033599)2.87047281
73Arp2/3 complex-mediated actin nucleation (GO:0034314)2.85011259
74embryonic process involved in female pregnancy (GO:0060136)2.84599392
75regulation of B cell differentiation (GO:0045577)2.84404695
76endosome to pigment granule transport (GO:0043485)2.84149146
77endosome to melanosome transport (GO:0035646)2.84149146
78response to peptidoglycan (GO:0032494)2.82652611
79viral mRNA export from host cell nucleus (GO:0046784)2.81598193
80purine-containing compound salvage (GO:0043101)2.81248386
81negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.80595701
82ncRNA 3-end processing (GO:0043628)2.78941673
83protoporphyrinogen IX metabolic process (GO:0046501)2.78915733
84T cell homeostasis (GO:0043029)2.78553683
85regulation of B cell receptor signaling pathway (GO:0050855)2.78296365
86negative regulation of RNA splicing (GO:0033119)2.78058803
87UV protection (GO:0009650)2.76507228
88sequestering of actin monomers (GO:0042989)2.75675444
89positive regulation of lamellipodium assembly (GO:0010592)2.75076872
90cellular response to virus (GO:0098586)2.73289089
91apoptotic process involved in morphogenesis (GO:0060561)2.69786717
92positive regulation of granulocyte differentiation (GO:0030854)2.69108110
93platelet dense granule organization (GO:0060155)2.66272778
94intracellular estrogen receptor signaling pathway (GO:0030520)2.64976383
95negative regulation of skeletal muscle tissue development (GO:0048642)2.63033233
96pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.62824532
97ribonucleoprotein complex biogenesis (GO:0022613)2.59977900
98iron-sulfur cluster assembly (GO:0016226)2.58415575
99metallo-sulfur cluster assembly (GO:0031163)2.58415575
100regulation of regulatory T cell differentiation (GO:0045589)2.58132519
101pentose-phosphate shunt (GO:0006098)2.55803424
102negative regulation of innate immune response (GO:0045824)2.54832840
103tricarboxylic acid metabolic process (GO:0072350)2.53775730
104regulation of type I interferon-mediated signaling pathway (GO:0060338)2.53569898
105oxidative phosphorylation (GO:0006119)2.52653640
106pentose metabolic process (GO:0019321)2.51279685
107telomere maintenance via recombination (GO:0000722)2.50751125
108nuclear envelope reassembly (GO:0031468)2.50575876
109mitotic nuclear envelope reassembly (GO:0007084)2.50575876
110endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.50247203
111stress fiber assembly (GO:0043149)2.49900737
112regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.49638771
113regulation of erythrocyte differentiation (GO:0045646)2.48497287
114creatine metabolic process (GO:0006600)2.48355751
115cell-substrate adherens junction assembly (GO:0007045)2.48297530
116focal adhesion assembly (GO:0048041)2.48297530
117regulation of response to osmotic stress (GO:0047484)2.47140641
118heme biosynthetic process (GO:0006783)2.46530715
1193-UTR-mediated mRNA stabilization (GO:0070935)2.46158826
120negative regulation of cell killing (GO:0031342)2.46103158
121negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.46103158
122regulation of defense response to virus by virus (GO:0050690)2.42982673
123protein-DNA complex disassembly (GO:0032986)2.41409524
124nucleosome disassembly (GO:0006337)2.41409524
125modulation by virus of host morphology or physiology (GO:0019048)2.41388061
126negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.41175339
127positive thymic T cell selection (GO:0045059)2.41088275
128positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.41054853
129positive regulation of lamellipodium organization (GO:1902745)2.40908442
130regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.40664070
131regulation of superoxide anion generation (GO:0032928)2.40367462
132regulation of leukocyte degranulation (GO:0043300)2.39732719
133virion assembly (GO:0019068)2.39373406
134neutrophil activation involved in immune response (GO:0002283)2.38869484
135negative regulation of glycoprotein biosynthetic process (GO:0010561)2.38515295
136pyrimidine nucleotide catabolic process (GO:0006244)2.38339414
137modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.37908481
138modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.37908481
139positive regulation by organism of defense response of other organism involved in symbiotic interact2.37908481
140modulation by symbiont of host immune response (GO:0052553)2.37908481
141positive regulation by symbiont of host defense response (GO:0052509)2.37908481
142modulation by symbiont of host defense response (GO:0052031)2.37908481
143cellular response to thyroid hormone stimulus (GO:0097067)2.36865043
144secretory granule organization (GO:0033363)2.36583170
145defense response to protozoan (GO:0042832)2.36358425
146immunoglobulin mediated immune response (GO:0016064)2.36320566
147positive regulation of myotube differentiation (GO:0010831)2.36227051
148response to laminar fluid shear stress (GO:0034616)2.35776468
149mitochondrial calcium ion transport (GO:0006851)2.34994979
150adherens junction assembly (GO:0034333)2.33535890
151regulation of protein heterodimerization activity (GO:0043497)2.33407831
152response to muramyl dipeptide (GO:0032495)2.32436031
153regulation of interleukin-12 biosynthetic process (GO:0045075)2.32210313
154granulocyte differentiation (GO:0030851)2.31634016
155NIK/NF-kappaB signaling (GO:0038061)2.31335270
156mannose metabolic process (GO:0006013)2.30977106
157mitochondrial fusion (GO:0008053)2.30431674
158regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.30081233
159positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.29954294
160negative regulation of myotube differentiation (GO:0010832)2.29843169
161porphyrin-containing compound biosynthetic process (GO:0006779)2.29599959
162regulation of mast cell degranulation (GO:0043304)2.28970480
163megakaryocyte development (GO:0035855)2.28558052
164regulation of T cell receptor signaling pathway (GO:0050856)2.28132280
165protein targeting to plasma membrane (GO:0072661)2.27625813
166nucleotide-excision repair, DNA gap filling (GO:0006297)2.27476498
167response to protozoan (GO:0001562)2.27395128
168thymic T cell selection (GO:0045061)2.27045193
169spliceosomal snRNP assembly (GO:0000387)2.26576499
170cellular response to interleukin-4 (GO:0071353)2.26558085
171regulation of response to interferon-gamma (GO:0060330)2.26521870
172rRNA processing (GO:0006364)2.26348029
173negative regulation of myeloid cell apoptotic process (GO:0033033)2.25470095
174morphogenesis of an endothelium (GO:0003159)2.24662854
175protoporphyrinogen IX biosynthetic process (GO:0006782)2.24437564
176muscle filament sliding (GO:0030049)2.24403128
177actin-myosin filament sliding (GO:0033275)2.24403128
178negative regulation of stress fiber assembly (GO:0051497)2.22330427
179epithelial cell differentiation involved in prostate gland development (GO:0060742)2.22015212
180response to thyroid hormone (GO:0097066)2.21519419
181regulation of myeloid leukocyte mediated immunity (GO:0002886)2.21170635
182spliceosomal tri-snRNP complex assembly (GO:0000244)2.20764966
183negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.19215343
184amyloid precursor protein catabolic process (GO:0042987)2.19019567

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.69882035
2E2F7_22180533_ChIP-Seq_HELA_Human3.23043002
3MYC_22102868_ChIP-Seq_BL_Human2.89096319
4MYC_18555785_ChIP-Seq_MESCs_Mouse2.66414675
5* VDR_21846776_ChIP-Seq_THP-1_Human2.63129905
6SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.39783345
7* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.39318068
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39235997
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.23516343
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.19723424
11FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.18951602
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.17595200
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15793660
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.12775206
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.12227770
16* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11254014
17CIITA_25753668_ChIP-Seq_RAJI_Human2.10693375
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09205887
19* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.09108591
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07136526
21* ETS1_20019798_ChIP-Seq_JURKAT_Human2.07036730
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.04105825
23* XRN2_22483619_ChIP-Seq_HELA_Human1.98407753
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98029749
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.94335782
26SCL_19346495_ChIP-Seq_HPC-7_Human1.94296690
27RACK7_27058665_Chip-Seq_MCF-7_Human1.93211924
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.92797291
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.85621445
30VDR_23849224_ChIP-Seq_CD4+_Human1.83970145
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81320238
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79592785
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.79523588
34MAF_26560356_Chip-Seq_TH1_Human1.78635826
35* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.75626916
36* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.75045713
37UTX_26944678_Chip-Seq_JUKART_Human1.73871905
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.72392125
39ERG_20887958_ChIP-Seq_HPC-7_Mouse1.68444003
40* FOXP3_21729870_ChIP-Seq_TREG_Human1.64844108
41SPI1_23547873_ChIP-Seq_NB4_Human1.62269033
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61508212
43* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58160858
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.56102913
45GABP_19822575_ChIP-Seq_HepG2_Human1.55700102
46TCF7_22412390_ChIP-Seq_EML_Mouse1.54719656
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.54137474
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.54010885
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.53852553
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52825701
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50872622
52KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.50567253
53TP63_17297297_ChIP-ChIP_HaCaT_Human1.50489556
54GATA1_22383799_ChIP-Seq_G1ME_Mouse1.50399879
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48818160
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48252928
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.47602198
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47445760
59* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45997565
60VDR_24763502_ChIP-Seq_THP-1_Human1.45602847
61* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44466512
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44361080
63DCP1A_22483619_ChIP-Seq_HELA_Human1.43705766
64* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.43546343
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43203544
66MAF_26560356_Chip-Seq_TH2_Human1.41509865
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.40687665
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38758918
69* RUNX1_22412390_ChIP-Seq_EML_Mouse1.38726223
70MYB_26560356_Chip-Seq_TH2_Human1.38418284
71* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.38302347
72CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38077451
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.36493780
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.33656211
75STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32926098
76STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.32799873
77* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32782711
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32000083
79NCOR1_26117541_ChIP-Seq_K562_Human1.30067889
80E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29723583
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28186394
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27848231
83LXR_22292898_ChIP-Seq_THP-1_Human1.27558171
84BCL6_27268052_Chip-Seq_Bcells_Human1.27488032
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26139204
86YY1_21170310_ChIP-Seq_MESCs_Mouse1.25895823
87ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24736942
88* TTF2_22483619_ChIP-Seq_HELA_Human1.24246714
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24108862
90* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23516534
91MYB_26560356_Chip-Seq_TH1_Human1.22863472
92BCOR_27268052_Chip-Seq_Bcells_Human1.22182182
93MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21833133
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.21744596
95* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21171968
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20836557
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20609625
98PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20195823
99KDM2B_26808549_Chip-Seq_DND41_Human1.20053621
100LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19322339
101GATA1_19941827_ChIP-Seq_MEL_Mouse1.18910868
102UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17970584
103* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17489238
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17189362
105GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16706398
106ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16229768
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15624894
108KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15367836
109TFEB_21752829_ChIP-Seq_HELA_Human1.13654087
110* ATF3_27146783_Chip-Seq_COLON_Human1.13448455
111* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12621677
112HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12405375
113SMC4_20622854_ChIP-Seq_HELA_Human1.12008518
114KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11992653
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11516562
116KDM2B_26808549_Chip-Seq_JURKAT_Human1.11192732
117PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10810404
118NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10743819
119TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10646229
120ELF1_20517297_ChIP-Seq_JURKAT_Human1.10458529
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09933270
122KDM2B_26808549_Chip-Seq_K562_Human1.09810118
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09655848
124YY1_22570637_ChIP-Seq_MALME-3M_Human1.09299963
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09290404
126ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08884482
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08662903
128CTCF_26484167_Chip-Seq_Bcells_Mouse1.08580340
129STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08423773
130MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08360025
131CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08281698
132GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08201876
133EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07854128
134SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07791927
135LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07685856
136DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07443449
137P68_20966046_ChIP-Seq_HELA_Human1.07393060
138BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07265205
139* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07051876
140* CLOCK_20551151_ChIP-Seq_293T_Human1.06649626
141NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06321274
142ESR2_21235772_ChIP-Seq_MCF-7_Human1.06154719
143CTCF_21964334_Chip-Seq_Bcells_Human1.06142386
144ZNF263_19887448_ChIP-Seq_K562_Human1.02495651

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.37638340
2MP0003763_abnormal_thymus_physiology3.18110775
3MP0000685_abnormal_immune_system3.10785309
4MP0001835_abnormal_antigen_presentation2.86073999
5MP0002396_abnormal_hematopoietic_system2.83379791
6MP0008260_abnormal_autophagy2.80410460
7MP0005671_abnormal_response_to2.61740616
8MP0004808_abnormal_hematopoietic_stem2.49872861
9MP0003705_abnormal_hypodermis_morpholog2.45964810
10MP0002398_abnormal_bone_marrow2.44337803
11MP0001545_abnormal_hematopoietic_system2.36153670
12MP0005397_hematopoietic_system_phenotyp2.36153670
13MP0003693_abnormal_embryo_hatching2.25328319
14MP0000490_abnormal_crypts_of2.22346671
15MP0001800_abnormal_humoral_immune2.19470617
16MP0002420_abnormal_adaptive_immunity2.15418584
17MP0009785_altered_susceptibility_to2.12907395
18MP0001819_abnormal_immune_cell2.12348170
19MP0004185_abnormal_adipocyte_glucose2.11815708
20MP0009333_abnormal_splenocyte_physiolog2.09094138
21MP0002722_abnormal_immune_system2.08282597
22MP0000689_abnormal_spleen_morphology2.07962565
23MP0000465_gastrointestinal_hemorrhage2.05817022
24MP0002452_abnormal_antigen_presenting2.02764601
25MP0009278_abnormal_bone_marrow2.02515944
26MP0000716_abnormal_immune_system2.01291632
27MP0003866_abnormal_defecation1.99205573
28MP0002723_abnormal_immune_serum1.97819692
29MP0000703_abnormal_thymus_morphology1.97162463
30MP0005025_abnormal_response_to1.95073218
31MP0002429_abnormal_blood_cell1.93338363
32MP0005000_abnormal_immune_tolerance1.86868623
33MP0003077_abnormal_cell_cycle1.83536640
34MP0001873_stomach_inflammation1.80388039
35MP0002877_abnormal_melanocyte_morpholog1.80043085
36MP0010155_abnormal_intestine_physiology1.79676759
37MP0008007_abnormal_cellular_replicative1.72719593
38MP0005387_immune_system_phenotype1.71736442
39MP0001790_abnormal_immune_system1.71736442
40MP0003436_decreased_susceptibility_to1.71350046
41MP0001853_heart_inflammation1.71140328
42MP0005076_abnormal_cell_differentiation1.70449761
43MP0002405_respiratory_system_inflammati1.70123343
44MP0004233_abnormal_muscle_weight1.69836373
45MP0002166_altered_tumor_susceptibility1.69644444
46MP0005075_abnormal_melanosome_morpholog1.67315928
47MP0005464_abnormal_platelet_physiology1.66610224
48MP0010094_abnormal_chromosome_stability1.64271892
49MP0000747_muscle_weakness1.62136627
50MP0005666_abnormal_adipose_tissue1.61297375
51MP0003566_abnormal_cell_adhesion1.59571346
52MP0006054_spinal_hemorrhage1.59053335
53MP0003656_abnormal_erythrocyte_physiolo1.56801794
54MP0004957_abnormal_blastocyst_morpholog1.56520271
55MP0000759_abnormal_skeletal_muscle1.52478472
56MP0004858_abnormal_nervous_system1.48880388
57MP0002148_abnormal_hypersensitivity_rea1.47253294
58MP0005083_abnormal_biliary_tract1.41097458
59MP0004087_abnormal_muscle_fiber1.38507205
60MP0005174_abnormal_tail_pigmentation1.37496463
61MP0002019_abnormal_tumor_incidence1.37479229
62MP0003111_abnormal_nucleus_morphology1.36679728
63MP0003453_abnormal_keratinocyte_physiol1.34425471
64MP0002419_abnormal_innate_immunity1.33160795
65MP0005375_adipose_tissue_phenotype1.33050944
66MP0001849_ear_inflammation1.28884167
67MP0003724_increased_susceptibility_to1.28351576
68MP0002132_abnormal_respiratory_system1.28333835
69MP0003567_abnormal_fetal_cardiomyocyte1.28123191
70MP0002332_abnormal_exercise_endurance1.27743911
71MP0000313_abnormal_cell_death1.25827399
72MP0001845_abnormal_inflammatory_respons1.24831854
73MP0006036_abnormal_mitochondrial_physio1.20892526
74MP0005501_abnormal_skin_physiology1.20181453
75MP0003075_altered_response_to1.15310461
76MP0004147_increased_porphyrin_level1.15029040
77MP0003806_abnormal_nucleotide_metabolis1.15007638
78MP0008058_abnormal_DNA_repair1.13627924
79MP0005670_abnormal_white_adipose1.12593742
80MP0002796_impaired_skin_barrier1.11862749
81MP0002269_muscular_atrophy1.07605064
82MP0003329_amyloid_beta_deposits1.06070498
83MP0000003_abnormal_adipose_tissue1.05955003
84MP0005058_abnormal_lysosome_morphology1.05834236
85MP0003300_gastrointestinal_ulcer1.05155448
86MP0003943_abnormal_hepatobiliary_system1.04946519
87MP0003221_abnormal_cardiomyocyte_apopto1.04073017
88MP0004947_skin_inflammation1.03706041
89MP0000858_altered_metastatic_potential1.02258986
90MP0004036_abnormal_muscle_relaxation1.01562376
91MP0003828_pulmonary_edema1.01363215
92MP0000733_abnormal_muscle_development1.01072173
93MP0000358_abnormal_cell_content/0.96800576
94MP0002998_abnormal_bone_remodeling0.95857374
95MP0002933_joint_inflammation0.95790969
96MP0008438_abnormal_cutaneous_collagen0.95732345
97MP0000477_abnormal_intestine_morphology0.95305969
98MP0002006_tumorigenesis0.93902034
99MP0001730_embryonic_growth_arrest0.93335048
100MP0003183_abnormal_peptide_metabolism0.93285348
101MP0002095_abnormal_skin_pigmentation0.92808876
102MP0005165_increased_susceptibility_to0.92480964
103MP0009840_abnormal_foam_cell0.92039955
104MP0003091_abnormal_cell_migration0.90102331
105MP0000350_abnormal_cell_proliferation0.89166328
106MP0001851_eye_inflammation0.87095281
107MP0006082_CNS_inflammation0.86375682
108MP0003646_muscle_fatigue0.85284053
109MP0008469_abnormal_protein_level0.85252135
110MP0005621_abnormal_cell_physiology0.84046188
111MP0001879_abnormal_lymphatic_vessel0.83455602
112MP0004084_abnormal_cardiac_muscle0.83452583
113MP0009931_abnormal_skin_appearance0.82867334
114MP0002080_prenatal_lethality0.82613893
115MP0003191_abnormal_cellular_cholesterol0.82443494
116MP0003279_aneurysm0.81203333
117MP0002106_abnormal_muscle_physiology0.80650050
118MP0000749_muscle_degeneration0.80635859
119MP0000678_abnormal_parathyroid_gland0.80574896
120MP0004145_abnormal_muscle_electrophysio0.78432216
121MP0000751_myopathy0.78356958
122MP0010630_abnormal_cardiac_muscle0.77910725
123MP0004510_myositis0.77724955
124MP0003303_peritoneal_inflammation0.75216722
125MP0001697_abnormal_embryo_size0.75058451
126MP0002653_abnormal_ependyma_morphology0.74685035
127MP0001663_abnormal_digestive_system0.72443691
128MP0000750_abnormal_muscle_regeneration0.71082682
129MP0002089_abnormal_postnatal_growth/wei0.70448348
130MP0000343_altered_response_to0.69676191
131MP0000371_diluted_coat_color0.68863847
132MP0004130_abnormal_muscle_cell0.68181107
133MP0008961_abnormal_basal_metabolism0.67776538
134MP0005330_cardiomyopathy0.66644192
135MP0010368_abnormal_lymphatic_system0.65340819
136MP0010352_gastrointestinal_tract_polyps0.64335138
137MP0003172_abnormal_lysosome_physiology0.62809438
138MP0001533_abnormal_skeleton_physiology0.62493969

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.81614318
2Chronic otitis media (HP:0000389)4.48604376
3IgM deficiency (HP:0002850)4.45137397
4Reticulocytopenia (HP:0001896)4.20392748
5Abnormality of cells of the erythroid lineage (HP:0012130)4.12265173
6Abnormal number of erythroid precursors (HP:0012131)3.97772609
7Thrombocytosis (HP:0001894)3.90167137
8Distal lower limb muscle weakness (HP:0009053)3.77960188
9Abnormality of the nasal mucosa (HP:0000433)3.74460591
10Increased connective tissue (HP:0009025)3.59412910
11Recurrent bronchitis (HP:0002837)3.56514220
12Nemaline bodies (HP:0003798)3.50422853
13Muscle fiber inclusion bodies (HP:0100299)3.46634533
14Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.42129017
15Aplastic anemia (HP:0001915)3.37566190
16Distal lower limb amyotrophy (HP:0008944)3.31082764
17Abnormality of the heme biosynthetic pathway (HP:0010472)3.29694555
18Panhypogammaglobulinemia (HP:0003139)3.25897533
19Vertebral compression fractures (HP:0002953)3.19623198
20Nasal polyposis (HP:0100582)3.14225678
21Type 1 muscle fiber predominance (HP:0003803)3.06467563
22Abnormality of skeletal muscle fiber size (HP:0012084)3.05831455
23Large eyes (HP:0001090)3.04532089
24Ragged-red muscle fibers (HP:0003200)3.00952951
25Petechiae (HP:0000967)2.96703090
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.92803358
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.92803358
28Fatigue (HP:0012378)2.83279710
29Achilles tendon contracture (HP:0001771)2.82797881
30Pallor (HP:0000980)2.80637169
31Poikiloderma (HP:0001029)2.76830897
32Increased variability in muscle fiber diameter (HP:0003557)2.74929803
33Gastrointestinal inflammation (HP:0004386)2.72423077
34Gastrointestinal stroma tumor (HP:0100723)2.71656391
35Agammaglobulinemia (HP:0004432)2.71517900
36Cellulitis (HP:0100658)2.70880334
37Recurrent viral infections (HP:0004429)2.65678183
38Abnormality of T cell physiology (HP:0011840)2.65021688
39Hepatocellular necrosis (HP:0001404)2.65008414
40Abnormality of T cells (HP:0002843)2.63324691
41Reticulocytosis (HP:0001923)2.62322775
42Eczematoid dermatitis (HP:0000976)2.57794913
43Difficulty climbing stairs (HP:0003551)2.51794461
44Abnormality of the Achilles tendon (HP:0005109)2.50721595
45Asymmetric septal hypertrophy (HP:0001670)2.48738897
46Inflammation of the large intestine (HP:0002037)2.46497031
47Myositis (HP:0100614)2.45285462
48Abnormal gallbladder physiology (HP:0012438)2.45280061
49Cholecystitis (HP:0001082)2.45280061
50Neck muscle weakness (HP:0000467)2.44400262
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.43793629
52Increased serum ferritin (HP:0003281)2.42269606
53Colitis (HP:0002583)2.42022453
54Hepatic necrosis (HP:0002605)2.39226943
55Microretrognathia (HP:0000308)2.38316181
56Abnormality of B cell number (HP:0010975)2.38101104
57B lymphocytopenia (HP:0010976)2.38101104
58Polycythemia (HP:0001901)2.36428308
59Abnormality of cells of the lymphoid lineage (HP:0012140)2.36052556
60EMG: myopathic abnormalities (HP:0003458)2.36024164
61Bulbar palsy (HP:0001283)2.35159649
62Lymphopenia (HP:0001888)2.34835947
63Chronic sinusitis (HP:0011109)2.32734169
64Prolonged bleeding time (HP:0003010)2.32269720
65Muscle fiber atrophy (HP:0100295)2.28445071
66Interstitial pulmonary disease (HP:0006530)2.28179786
67Recurrent fungal infections (HP:0002841)2.27746003
68Absent rod-and cone-mediated responses on ERG (HP:0007688)2.26081913
69Spontaneous hematomas (HP:0007420)2.26058004
70Macrocytic anemia (HP:0001972)2.25773266
71Muscle stiffness (HP:0003552)2.23450378
72IgG deficiency (HP:0004315)2.23365872
73Muscle fiber splitting (HP:0003555)2.22878387
74Increased muscle lipid content (HP:0009058)2.22197576
75Bronchitis (HP:0012387)2.20808012
76Albinism (HP:0001022)2.19802017
77Centrally nucleated skeletal muscle fibers (HP:0003687)2.17854900
78Lymphoma (HP:0002665)2.16104667
79Mildly elevated creatine phosphokinase (HP:0008180)2.15909359
80Cholelithiasis (HP:0001081)2.13965916
81Increased intramyocellular lipid droplets (HP:0012240)2.13677521
82Recurrent abscess formation (HP:0002722)2.13628711
83Hyporeflexia of lower limbs (HP:0002600)2.12860999
84Type I transferrin isoform profile (HP:0003642)2.12093019
85Hyperacusis (HP:0010780)2.10909649
86Dysostosis multiplex (HP:0000943)2.09921775
87Meningitis (HP:0001287)2.09233303
88Hypertensive crisis (HP:0100735)2.08656297
89Microcytic anemia (HP:0001935)2.08364928
90Abnormality of glycolipid metabolism (HP:0010969)2.08072927
91Abnormality of liposaccharide metabolism (HP:0010968)2.08072927
92Abnormality of glycosphingolipid metabolism (HP:0004343)2.08072927
93Hypertriglyceridemia (HP:0002155)2.05941703
94Verrucae (HP:0200043)2.05704388
95Papilloma (HP:0012740)2.05704388
96Round ear (HP:0100830)2.05511608
97Type 2 muscle fiber atrophy (HP:0003554)2.04797087
98Protrusio acetabuli (HP:0003179)2.04744497
99T lymphocytopenia (HP:0005403)2.02035817
100Emphysema (HP:0002097)2.01935729
101Pustule (HP:0200039)2.01442816
102Abnormal protein glycosylation (HP:0012346)2.01331211
103Abnormal glycosylation (HP:0012345)2.01331211
104Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01331211
105Abnormal protein N-linked glycosylation (HP:0012347)2.01331211
106Hepatosplenomegaly (HP:0001433)2.00799159
107Spinal rigidity (HP:0003306)1.99946761
108Obstructive lung disease (HP:0006536)1.99769270
109Chronic obstructive pulmonary disease (HP:0006510)1.99769270
110Easy fatigability (HP:0003388)1.98247767
111Lower limb amyotrophy (HP:0007210)1.96958635
112Impaired platelet aggregation (HP:0003540)1.96848716
113Abnormal platelet function (HP:0011869)1.96848716
114Annular pancreas (HP:0001734)1.95792639
115Ulnar deviation of the wrist (HP:0003049)1.95605156
116Basal cell carcinoma (HP:0002671)1.94911023
117Abnormal rod and cone electroretinograms (HP:0008323)1.93718676
118Purpura (HP:0000979)1.93345800
119Generalized amyotrophy (HP:0003700)1.93318664
120Myopathic facies (HP:0002058)1.89183234
121Growth hormone excess (HP:0000845)1.88743673
122Increased cerebral lipofuscin (HP:0011813)1.87479031
123Abnormality of iron homeostasis (HP:0011031)1.86789532
124J-shaped sella turcica (HP:0002680)1.85579644
125Abnormality of macrophages (HP:0004311)1.84759154
126Abnormality of the thoracic spine (HP:0100711)1.83010077
127Abnormality of T cell number (HP:0011839)1.82833127
128Recurrent bacterial skin infections (HP:0005406)1.82619845
129Ventricular tachycardia (HP:0004756)1.82123553
130Pancytopenia (HP:0001876)1.81198421
131Broad face (HP:0000283)1.80425737
132Distal upper limb amyotrophy (HP:0007149)1.80292971
133Upper limb amyotrophy (HP:0009129)1.80292971
134Hypergammaglobulinemia (HP:0010702)1.80142752
135Difficulty running (HP:0009046)1.80127262
136Asplenia (HP:0001746)1.79828886
137Thoracic kyphosis (HP:0002942)1.77857678
138Rhabdomyolysis (HP:0003201)1.77824651
139Epistaxis (HP:0000421)1.77746065
140Amyloidosis (HP:0011034)1.77464581
141Calcaneovalgus deformity (HP:0001848)1.77088534
142Colon cancer (HP:0003003)1.75967624
143Back pain (HP:0003418)1.75418023
144Exertional dyspnea (HP:0002875)1.74960084
145Foot dorsiflexor weakness (HP:0009027)1.74731406
146Exercise-induced muscle cramps (HP:0003710)1.74694563
147Mediastinal lymphadenopathy (HP:0100721)1.74562945
148Limb-girdle muscle atrophy (HP:0003797)1.72813243
149Neutropenia (HP:0001875)1.72120048
150Granulocytopenia (HP:0001913)1.71919875
151Posterior subcapsular cataract (HP:0007787)1.71562775
152Axonal loss (HP:0003447)1.71158780
153Abnormal gallbladder morphology (HP:0012437)1.70386372
154Premature rupture of membranes (HP:0001788)1.70268787
155Myoglobinuria (HP:0002913)1.69189525
156Loss of speech (HP:0002371)1.69084410
157Leukocytosis (HP:0001974)1.68456729
158Amaurosis fugax (HP:0100576)1.68400154
159Scapular winging (HP:0003691)1.68378795
160Central scotoma (HP:0000603)1.67943028
161Poor head control (HP:0002421)1.67706214
162Progressive muscle weakness (HP:0003323)1.67555133
163Abnormality of the anterior horn cell (HP:0006802)1.66643549
164Degeneration of anterior horn cells (HP:0002398)1.66643549
165Stridor (HP:0010307)1.65983501
166Trismus (HP:0000211)1.65524462
167Exercise-induced myalgia (HP:0003738)1.65195993
168Vacuolated lymphocytes (HP:0001922)1.64741673
169Increased serum lactate (HP:0002151)1.64725560
170Hemorrhage of the eye (HP:0011885)1.64224590
171Increased IgE level (HP:0003212)1.62845391
172Gastrointestinal dysmotility (HP:0002579)1.62439147
173Polygenic inheritance (HP:0010982)1.62192489
174Abnormality of reticulocytes (HP:0004312)1.61763757
175Hypercortisolism (HP:0001578)1.61057518
176Increased neuronal autofluorescent lipopigment (HP:0002074)1.60547841
177Upper motor neuron abnormality (HP:0002127)1.58895986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.54813905
2EEF2K3.15320361
3PRPF4B3.01540872
4NME22.94767525
5MAP3K102.90845957
6SMG12.64586504
7IRAK32.56236721
8DYRK32.45951560
9FLT32.14667785
10TGFBR12.11704654
11MAP3K112.10886868
12SIK12.08328955
13PKN22.07809347
14BCKDK2.07593386
15TGFBR22.01009296
16KDR1.90995803
17BUB11.88269841
18BTK1.87607765
19RPS6KA41.86250957
20TRIB31.85078159
21ICK1.84067451
22KIT1.82472730
23ZAP701.73935707
24LRRK21.66890786
25EPHA21.65391814
26TESK21.64011210
27STK161.62842176
28TIE11.61745692
29ERN11.58738989
30ARAF1.54589061
31TBK11.51016664
32JAK31.46201676
33SCYL21.46108415
34MAPKAPK31.44772592
35MAP2K31.41992253
36RPS6KB21.40870190
37TLK11.38240095
38NEK21.37884290
39TXK1.37340718
40WEE11.36009227
41GRK61.35634260
42BLK1.32835078
43RIPK11.28989996
44FGFR41.28634943
45VRK21.28497562
46ACVR1B1.27702572
47SYK1.25328363
48CDK191.24222105
49STK101.19955255
50TEC1.17161482
51EPHB11.14886343
52ITK1.11882610
53PIM21.11313653
54MAP3K11.10353994
55CSF1R1.09859463
56EIF2AK11.04529162
57TYK20.97318619
58TAOK30.96928534
59OBSCN0.96799199
60BMX0.95358154
61PAK40.94768662
62DYRK1B0.92622841
63RIPK40.88868298
64ILK0.88212926
65IKBKE0.87258197
66MAPK110.85080709
67CCNB10.85050054
68TTN0.82916291
69MATK0.81037228
70PASK0.80660408
71LIMK10.78338380
72IRAK20.77710747
73CDK40.74498525
74PIM10.74183778
75ABL20.73982682
76MAP3K60.73603816
77MARK20.73446112
78BRAF0.71081882
79PRKD20.70028959
80LCK0.69569966
81MAP3K80.69297077
82LYN0.69171790
83RAF10.67148334
84NLK0.66850880
85CDK120.66737210
86PDPK10.66647544
87MAPK120.62704874
88TAOK20.62641560
89KSR20.61272537
90MST1R0.60198117
91HIPK20.60048389
92IRAK40.59967866
93MAP3K70.59663835
94TNK20.59451985
95FES0.58778640
96IKBKB0.58012779
97MOS0.55746817
98TAOK10.54197991
99MAP3K130.53983522
100CSK0.53960090
101RPS6KA20.53703488
102DAPK10.53447814
103CDK70.53313748
104MAP3K140.52897695
105CLK10.52684445
106HCK0.51792659
107AURKB0.50107810
108PHKG10.49874424
109PHKG20.49874424
110* MTOR0.49570104
111CAMKK20.49119507
112MYLK0.48500725
113MAPK150.48500695
114LMTK20.47794165
115VRK10.47592957
116MAP2K20.47052385
117RPS6KA60.46543163
118PRKG20.45277316
119CDC42BPA0.45037354
120RPS6KA50.44280160
121STK40.43910827
122TESK10.43353928
123MAP3K30.42886492
124ATR0.42802074
125MUSK0.42552375
126AURKA0.41058766
127PTK60.40854958
128MAPK40.39815442
129BRSK10.39769125
130MAP2K60.38760886
131PDK10.38436295
132PTK20.38214911
133MAPKAPK20.37593750
134SIK30.35845058
135RPS6KL10.34523618
136RPS6KC10.34523618
137NEK10.33248568

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.45010413
2DNA replication_Homo sapiens_hsa030303.54000944
3Primary immunodeficiency_Homo sapiens_hsa053403.04148884
4Mismatch repair_Homo sapiens_hsa034302.74887464
5Base excision repair_Homo sapiens_hsa034102.70891520
6Spliceosome_Homo sapiens_hsa030402.62029763
7Proteasome_Homo sapiens_hsa030502.08398241
8B cell receptor signaling pathway_Homo sapiens_hsa046622.05552801
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01942298
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.81476229
11Pyrimidine metabolism_Homo sapiens_hsa002401.69046433
12Sulfur relay system_Homo sapiens_hsa041221.68860463
13Bladder cancer_Homo sapiens_hsa052191.65419261
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.60438640
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.60389616
16Antigen processing and presentation_Homo sapiens_hsa046121.53823737
17Nucleotide excision repair_Homo sapiens_hsa034201.53567915
18RNA polymerase_Homo sapiens_hsa030201.45043337
19Pentose phosphate pathway_Homo sapiens_hsa000301.42876113
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41077673
21Acute myeloid leukemia_Homo sapiens_hsa052211.39476958
22Shigellosis_Homo sapiens_hsa051311.37869207
23RNA transport_Homo sapiens_hsa030131.36207314
24Cell cycle_Homo sapiens_hsa041101.34744366
25Herpes simplex infection_Homo sapiens_hsa051681.34225031
26Measles_Homo sapiens_hsa051621.31509988
27Leishmaniasis_Homo sapiens_hsa051401.31252283
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.29800108
29Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.29488710
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27882453
31T cell receptor signaling pathway_Homo sapiens_hsa046601.26428747
32Homologous recombination_Homo sapiens_hsa034401.26338761
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25607474
34Insulin signaling pathway_Homo sapiens_hsa049101.23570808
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23282082
36Epstein-Barr virus infection_Homo sapiens_hsa051691.21199032
37N-Glycan biosynthesis_Homo sapiens_hsa005101.18727596
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.17899864
39Chronic myeloid leukemia_Homo sapiens_hsa052201.17125560
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15674695
41Apoptosis_Homo sapiens_hsa042101.15214515
42Lysosome_Homo sapiens_hsa041421.12758982
43Legionellosis_Homo sapiens_hsa051341.11468668
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09404740
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.07596255
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.07229598
47Endometrial cancer_Homo sapiens_hsa052131.05888323
48RNA degradation_Homo sapiens_hsa030181.05216021
49p53 signaling pathway_Homo sapiens_hsa041151.04571014
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04290324
51Other glycan degradation_Homo sapiens_hsa005111.04260319
52Adipocytokine signaling pathway_Homo sapiens_hsa049201.03977409
53Hepatitis C_Homo sapiens_hsa051601.01103712
54Notch signaling pathway_Homo sapiens_hsa043300.99753457
55Osteoclast differentiation_Homo sapiens_hsa043800.97957165
56AMPK signaling pathway_Homo sapiens_hsa041520.97883446
57Viral carcinogenesis_Homo sapiens_hsa052030.97660743
58Endocytosis_Homo sapiens_hsa041440.97348162
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96271908
60Hematopoietic cell lineage_Homo sapiens_hsa046400.96117869
61Systemic lupus erythematosus_Homo sapiens_hsa053220.94975101
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94846285
63Viral myocarditis_Homo sapiens_hsa054160.92037261
64Colorectal cancer_Homo sapiens_hsa052100.91651264
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89904728
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89113021
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.88567343
68Hepatitis B_Homo sapiens_hsa051610.87871628
69HTLV-I infection_Homo sapiens_hsa051660.87732257
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.87357974
71Folate biosynthesis_Homo sapiens_hsa007900.87202615
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85977705
73VEGF signaling pathway_Homo sapiens_hsa043700.85766423
74Malaria_Homo sapiens_hsa051440.84309812
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83019792
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80984954
77Thyroid cancer_Homo sapiens_hsa052160.79796777
78Renal cell carcinoma_Homo sapiens_hsa052110.79722022
79Insulin resistance_Homo sapiens_hsa049310.79624551
80Prion diseases_Homo sapiens_hsa050200.78341221
81Non-homologous end-joining_Homo sapiens_hsa034500.77735207
82Non-small cell lung cancer_Homo sapiens_hsa052230.77442399
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.77387338
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76172023
85mTOR signaling pathway_Homo sapiens_hsa041500.75956880
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75679210
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75555463
88Platelet activation_Homo sapiens_hsa046110.75262272
89Purine metabolism_Homo sapiens_hsa002300.75023092
90Parkinsons disease_Homo sapiens_hsa050120.72775698
91Toxoplasmosis_Homo sapiens_hsa051450.72658789
92Pancreatic cancer_Homo sapiens_hsa052120.70354971
93Galactose metabolism_Homo sapiens_hsa000520.69721236
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69436476
95Influenza A_Homo sapiens_hsa051640.68323663
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67724774
97Glioma_Homo sapiens_hsa052140.67121748
98mRNA surveillance pathway_Homo sapiens_hsa030150.66720554
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.65494323
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63718727
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62788748
102Vibrio cholerae infection_Homo sapiens_hsa051100.62124192
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.61642115
104Fatty acid elongation_Homo sapiens_hsa000620.60541267
105Small cell lung cancer_Homo sapiens_hsa052220.59942990
106Alcoholism_Homo sapiens_hsa050340.59557078
107ErbB signaling pathway_Homo sapiens_hsa040120.59447551
108Focal adhesion_Homo sapiens_hsa045100.58995898
109Fructose and mannose metabolism_Homo sapiens_hsa000510.58937646
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58441184
111Biosynthesis of amino acids_Homo sapiens_hsa012300.57037071
112Basal transcription factors_Homo sapiens_hsa030220.56444528
113Phenylalanine metabolism_Homo sapiens_hsa003600.55627078
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55172121
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.54797726
116Carbon metabolism_Homo sapiens_hsa012000.54160901
117Fanconi anemia pathway_Homo sapiens_hsa034600.54135634
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53792659
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53702911
120Dilated cardiomyopathy_Homo sapiens_hsa054140.53521850
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52012201
122Amoebiasis_Homo sapiens_hsa051460.51818997
123Inositol phosphate metabolism_Homo sapiens_hsa005620.49891401
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49383116
125Salmonella infection_Homo sapiens_hsa051320.48136712
126Tuberculosis_Homo sapiens_hsa051520.47206565
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46905582
128Protein export_Homo sapiens_hsa030600.46334018
129HIF-1 signaling pathway_Homo sapiens_hsa040660.46029317
130TNF signaling pathway_Homo sapiens_hsa046680.41419965
131Pertussis_Homo sapiens_hsa051330.41045391
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40628665
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40019199
134Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39997100
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39389741
136Regulation of autophagy_Homo sapiens_hsa041400.38448166
137Chemokine signaling pathway_Homo sapiens_hsa040620.38100155

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