MAFA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS; MIM 176730) (Olbrot et al., 2002 [PubMed 12011435]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)9.48140700
2Golgi transport vesicle coating (GO:0048200)9.48140700
3type B pancreatic cell development (GO:0003323)8.42449124
4glandular epithelial cell development (GO:0002068)7.29305931
5actin-myosin filament sliding (GO:0033275)6.98638148
6muscle filament sliding (GO:0030049)6.98638148
7endocrine pancreas development (GO:0031018)6.85652410
8protein maturation by protein folding (GO:0022417)6.75321147
9skeletal muscle contraction (GO:0003009)6.01697549
10activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.96810076
11positive regulation of glycolytic process (GO:0045821)5.96657790
12regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.96569188
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.86079845
14actin-mediated cell contraction (GO:0070252)5.74481194
15peptide hormone processing (GO:0016486)5.73017185
16glandular epithelial cell differentiation (GO:0002067)5.71539884
17positive regulation of nuclease activity (GO:0032075)5.69649839
18retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.68880477
19COPII vesicle coating (GO:0048208)5.64717284
20columnar/cuboidal epithelial cell development (GO:0002066)5.43258014
21response to muscle activity (GO:0014850)5.39280651
22plasma membrane repair (GO:0001778)5.36893587
23exocrine pancreas development (GO:0031017)5.29411738
24regulation of nuclease activity (GO:0032069)5.18268619
25myofibril assembly (GO:0030239)5.17442623
26protein retention in ER lumen (GO:0006621)5.15784510
27sarcoplasmic reticulum calcium ion transport (GO:0070296)5.14775504
28L-alpha-amino acid transmembrane transport (GO:1902475)5.10187362
29regulation of type B pancreatic cell apoptotic process (GO:2000674)5.06906661
30fatty acid homeostasis (GO:0055089)5.05198019
31negative regulation of gluconeogenesis (GO:0045721)5.00745243
32regulation of skeletal muscle contraction (GO:0014819)4.97382468
33endoplasmic reticulum unfolded protein response (GO:0030968)4.88485745
34fructose metabolic process (GO:0006000)4.83143815
35regulation of hexokinase activity (GO:1903299)4.74693887
36regulation of glucokinase activity (GO:0033131)4.74693887
37cellular response to unfolded protein (GO:0034620)4.71664797
38cellular response to vitamin D (GO:0071305)4.59789916
39ER-nucleus signaling pathway (GO:0006984)4.58823792
40vesicle coating (GO:0006901)4.58262792
41cellular response to topologically incorrect protein (GO:0035967)4.47804004
42positive regulation of insulin secretion (GO:0032024)4.34706502
43sarcomere organization (GO:0045214)4.29990435
44positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.26465309
45negative regulation of protein oligomerization (GO:0032460)4.26360451
46positive regulation of glycogen biosynthetic process (GO:0045725)4.26303358
47regulation of oxidative phosphorylation (GO:0002082)4.21898804
48actin filament-based movement (GO:0030048)4.19708955
49negative regulation of norepinephrine secretion (GO:0010700)4.16780002
50negative regulation of acute inflammatory response (GO:0002674)4.11355418
51regulation of insulin secretion (GO:0050796)4.09703117
52striated muscle contraction (GO:0006941)4.04807666
53glycogen catabolic process (GO:0005980)3.99048417
54membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.97489087
55regulation of relaxation of muscle (GO:1901077)3.97037403
56positive regulation of respiratory burst (GO:0060267)3.97036677
57cerebellar Purkinje cell layer development (GO:0021680)3.96603928
58cellular response to hepatocyte growth factor stimulus (GO:0035729)3.95465651
59response to hepatocyte growth factor (GO:0035728)3.95465651
60macroautophagy (GO:0016236)3.87698998
61* insulin secretion (GO:0030073)3.82596954
62muscle cell cellular homeostasis (GO:0046716)3.81672073
63intestinal cholesterol absorption (GO:0030299)3.79654950
64lactate metabolic process (GO:0006089)3.78513672
65response to endoplasmic reticulum stress (GO:0034976)3.76006950
66epithelial cell fate commitment (GO:0072148)3.75411028
67intestinal absorption (GO:0050892)3.73356632
68ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.73286096
69astrocyte differentiation (GO:0048708)3.71131071
70glucan catabolic process (GO:0009251)3.69872272
71positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.68868459
72response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.68437056
73regulation of peptide hormone secretion (GO:0090276)3.68034852
74positive regulation of glycogen metabolic process (GO:0070875)3.67781193
754-hydroxyproline metabolic process (GO:0019471)3.64691593
76response to ischemia (GO:0002931)3.63472887
77positive regulation of hormone biosynthetic process (GO:0046886)3.62793507
78chemosensory behavior (GO:0007635)3.62678997
79regulation of peptide secretion (GO:0002791)3.61926470
80glucan biosynthetic process (GO:0009250)3.61257083
81glycogen biosynthetic process (GO:0005978)3.61257083
82negative regulation of catecholamine secretion (GO:0033604)3.58702267
83creatine metabolic process (GO:0006600)3.58116362
84negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.56241716
85response to unfolded protein (GO:0006986)3.55576745
86negative regulation of insulin secretion (GO:0046676)3.52071150
87skeletal muscle fiber development (GO:0048741)3.51647259
88membrane repolarization during action potential (GO:0086011)3.50913250
89detection of calcium ion (GO:0005513)3.50783276
90protein targeting to Golgi (GO:0000042)3.50187039
91glycogen metabolic process (GO:0005977)3.50041415
92regulation of glucocorticoid metabolic process (GO:0031943)3.48147923
93positive regulation of peptide hormone secretion (GO:0090277)3.46530946
94skeletal muscle adaptation (GO:0043501)3.43664212
95sequestering of metal ion (GO:0051238)3.43424236
96regulation of Golgi to plasma membrane protein transport (GO:0042996)3.43106023
97muscle cell fate commitment (GO:0042693)3.42559119
98cellular glucan metabolic process (GO:0006073)3.41619086
99glucan metabolic process (GO:0044042)3.41619086
100positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.40935581
101intra-Golgi vesicle-mediated transport (GO:0006891)3.40482560
102cellular polysaccharide catabolic process (GO:0044247)3.40473679
103muscle contraction (GO:0006936)3.39984233
104ER overload response (GO:0006983)3.39895094
105response to topologically incorrect protein (GO:0035966)3.39874358
106positive regulation of histone deacetylation (GO:0031065)3.38485573
107Golgi organization (GO:0007030)3.38002242
108positive regulation of peptide secretion (GO:0002793)3.35961273
109regulation of energy homeostasis (GO:2000505)3.35777782
110negative regulation of glycogen biosynthetic process (GO:0045719)3.32242551
111peptidyl-asparagine modification (GO:0018196)3.31335689
112actomyosin structure organization (GO:0031032)3.31216070
113protein N-linked glycosylation via asparagine (GO:0018279)3.30424132
114inner ear receptor cell development (GO:0060119)3.23776462
115cellular response to vitamin (GO:0071295)3.20658997
116inositol phosphate catabolic process (GO:0071545)3.20221219
117calcium ion import (GO:0070509)3.18739498
118regulation of transcription involved in cell fate commitment (GO:0060850)3.18676768
119nucleoside diphosphate catabolic process (GO:0009134)3.18410069
120negative regulation of bone resorption (GO:0045779)3.17608083
121negative regulation of hormone biosynthetic process (GO:0032353)3.16670348
122negative regulation of hormone metabolic process (GO:0032351)3.16670348
123cellular response to glucagon stimulus (GO:0071377)3.16605776
124regulation of glycolytic process (GO:0006110)3.16435947
125establishment of protein localization to Golgi (GO:0072600)3.15277251
126toxin metabolic process (GO:0009404)3.14840380
127regulation of glucose import in response to insulin stimulus (GO:2001273)3.12293961
128* nitric oxide mediated signal transduction (GO:0007263)3.11990076
129succinate metabolic process (GO:0006105)3.08902748
130negative regulation of glycoprotein biosynthetic process (GO:0010561)3.08427653
131muscle system process (GO:0003012)3.07863830
132regulation of hormone secretion (GO:0046883)3.07703334
133positive regulation of insulin receptor signaling pathway (GO:0046628)3.06980213
134response to lipoprotein particle (GO:0055094)3.06751820
135intestinal epithelial cell development (GO:0060576)3.06637990
136polysaccharide catabolic process (GO:0000272)3.05370365
137myotube cell development (GO:0014904)3.05156575
138cardiac myofibril assembly (GO:0055003)3.04689945
139UDP-N-acetylglucosamine metabolic process (GO:0006047)3.04379372
140negative regulation of cell size (GO:0045792)3.04370994
141negative regulation of peptide hormone secretion (GO:0090278)3.03366643
142positive regulation of macroautophagy (GO:0016239)3.02428969
143positive regulation of protein autophosphorylation (GO:0031954)3.01955082
144cellular response to zinc ion (GO:0071294)3.00817645
145regulation of peptide transport (GO:0090087)3.00495453
146negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)3.00233799
147protein N-linked glycosylation (GO:0006487)2.99715335
148retrograde transport, vesicle recycling within Golgi (GO:0000301)2.98437619
149phosphorylated carbohydrate dephosphorylation (GO:0046838)2.95334720
150inositol phosphate dephosphorylation (GO:0046855)2.95334720
151ER to Golgi vesicle-mediated transport (GO:0006888)2.94760692
152regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.94699334
153negative regulation of peptide secretion (GO:0002792)2.93610808
154positive regulation of steroid biosynthetic process (GO:0010893)2.93556681
155negative regulation of Ras GTPase activity (GO:0034261)2.93372515
156energy reserve metabolic process (GO:0006112)2.93323284
157* peptide hormone secretion (GO:0030072)2.92193064
158ganglion development (GO:0061548)2.91860490
159endoplasmic reticulum organization (GO:0007029)2.91325782
160* peptide secretion (GO:0002790)2.90173163
161gluconeogenesis (GO:0006094)2.89933728
162response to activity (GO:0014823)2.89627039
163negative regulation of cytosolic calcium ion concentration (GO:0051481)2.89220425
164nodal signaling pathway (GO:0038092)2.85338499
165negative regulation of GTP catabolic process (GO:0033125)2.85074420
166negative regulation of GTPase activity (GO:0034260)2.85074420
167regulation of norepinephrine secretion (GO:0014061)2.84542590
168induction of positive chemotaxis (GO:0050930)2.83591919
169response to inactivity (GO:0014854)2.82435475
170activation of protein kinase B activity (GO:0032148)2.81939074
171* response to glucose (GO:0009749)2.81733566
172regulation of gluconeogenesis (GO:0006111)2.81543659
173positive regulation of hormone secretion (GO:0046887)2.81321219
174* response to hexose (GO:0009746)2.80744901
175negative regulation of glycogen metabolic process (GO:0070874)2.79781064

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.30530056
2GATA1_22025678_ChIP-Seq_K562_Human5.28029246
3STAT6_21828071_ChIP-Seq_BEAS2B_Human2.90960088
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.88777686
5ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.70676245
6DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.48576447
7TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.26290178
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.23524109
9* CBX2_27304074_Chip-Seq_ESCs_Mouse2.20285972
10HTT_18923047_ChIP-ChIP_STHdh_Human2.04071601
11* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.99628033
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99419259
13CDX2_19796622_ChIP-Seq_MESCs_Mouse1.98868761
14SOX2_27498859_Chip-Seq_STOMACH_Mouse1.91866980
15REST_21632747_ChIP-Seq_MESCs_Mouse1.90655976
16ESR1_20079471_ChIP-ChIP_T-47D_Human1.90420243
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.88388316
18IGF1R_20145208_ChIP-Seq_DFB_Human1.86870366
19ZNF274_21170338_ChIP-Seq_K562_Hela1.84008615
20GATA1_19941826_ChIP-Seq_K562_Human1.83857028
21DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.79172892
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75413321
23BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.73270597
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.69594499
25BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.69304869
26FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.65669079
27CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.64814235
28ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.64785102
29NR3C1_23031785_ChIP-Seq_PC12_Mouse1.60753108
30MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.59626388
31* TP53_20018659_ChIP-ChIP_R1E_Mouse1.59598991
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.56853090
33* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.52826318
34KDM2B_26808549_Chip-Seq_K562_Human1.52584889
35* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.52555409
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.51465684
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49815665
38* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.49510569
39* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.48281176
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.47470342
41ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45796186
42* EZH2_27304074_Chip-Seq_ESCs_Mouse1.42249039
43NFIB_24661679_ChIP-Seq_LUNG_Mouse1.40450562
44* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40314438
45CREB1_26743006_Chip-Seq_LNCaP_Human1.40155339
46* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.37746180
47* EZH2_27294783_Chip-Seq_ESCs_Mouse1.37637341
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34638577
49LXR_22158963_ChIP-Seq_LIVER_Mouse1.34060271
50PKCTHETA_26484144_Chip-Seq_BREAST_Human1.32432831
51* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31771818
52TDRD3_21172665_ChIP-Seq_MCF-7_Human1.31717864
53* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.30989617
54* LXR_22292898_ChIP-Seq_THP-1_Human1.29861014
55KDM2B_26808549_Chip-Seq_DND41_Human1.27553238
56ZNF263_19887448_ChIP-Seq_K562_Human1.26119817
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26098910
58FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.25316581
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23756344
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22582786
61* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22207644
62EZH2_22144423_ChIP-Seq_EOC_Human1.20712056
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.18385822
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17600912
65* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17524574
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16556287
67OCT4_20526341_ChIP-Seq_ESCs_Human1.15890813
68FOXA2_19822575_ChIP-Seq_HepG2_Human1.14959781
69AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13441243
70TCF7_22412390_ChIP-Seq_EML_Mouse1.13279106
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12569272
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12528776
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12501635
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12252507
75* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12083415
76* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11969643
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11891691
78CLOCK_20551151_ChIP-Seq_293T_Human1.11812806
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11630590
80P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10896455
81TFEB_21752829_ChIP-Seq_HELA_Human1.10779633
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09214104
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09170112
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09165974
85* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08949477
86DROSHA_22980978_ChIP-Seq_HELA_Human1.08442582
87CBP_21632823_ChIP-Seq_H3396_Human1.08086234
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07529474
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06561204
90RXR_22158963_ChIP-Seq_LIVER_Mouse1.06458852
91* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06083941
92GATA4_21415370_ChIP-Seq_HL-1_Mouse1.05770560
93TBX20_22080862_ChIP-Seq_HEART_Mouse1.05081745
94TBX20_22328084_ChIP-Seq_HEART_Mouse1.05081745
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03562347
96RAC3_21632823_ChIP-Seq_H3396_Human1.03525476
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03452764
98CTCF_27219007_Chip-Seq_Bcells_Human1.03436286
99FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03025665
100YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02865411
101GBX2_23144817_ChIP-Seq_PC3_Human1.02147030
102* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01878953
103ESR1_21235772_ChIP-Seq_MCF-7_Human1.01213236
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00471686
105RACK7_27058665_Chip-Seq_MCF-7_Human0.99861428
106PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99791052
107ER_23166858_ChIP-Seq_MCF-7_Human0.97778340
108* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97270820
109* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97047888
110* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96355296
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96309258
112FOXH1_21741376_ChIP-Seq_ESCs_Human0.95773424
113GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95691662
114ERG_21242973_ChIP-ChIP_JURKAT_Human0.95493186
115SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94653004
116* EED_16625203_ChIP-ChIP_MESCs_Mouse0.94575615
117SOX2_21211035_ChIP-Seq_LN229_Gbm0.91488977
118ISL1_27105846_Chip-Seq_CPCs_Mouse0.91005313
119SPI1_23127762_ChIP-Seq_K562_Human0.90800631
120STAT3_23295773_ChIP-Seq_U87_Human0.90746001
121STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90493222
122* AR_19668381_ChIP-Seq_PC3_Human0.90456896
123GATA3_21867929_ChIP-Seq_CD8_Mouse0.90264668
124FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90071622
125SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89988513
126PHF8_20622853_ChIP-Seq_HELA_Human0.88820138
127THAP11_20581084_ChIP-Seq_MESCs_Mouse0.88638103
128SMAD3_21741376_ChIP-Seq_ESCs_Human0.88346592
129RUNX1_27514584_Chip-Seq_MCF-7_Human0.87945932
130KDM2B_26808549_Chip-Seq_JURKAT_Human0.87219527
131FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87174780
132BP1_19119308_ChIP-ChIP_Hs578T_Human0.86982423
133FOXA1_25552417_ChIP-Seq_VCAP_Human0.86570658
134SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86489023
135* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86389441
136SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86276848
137* RNF2_27304074_Chip-Seq_ESCs_Mouse0.85978302
138EP300_21415370_ChIP-Seq_HL-1_Mouse0.85557377
139* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85359405
140FOXO3_23340844_ChIP-Seq_DLD1_Human0.85333144
141LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84852986
142SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.84562559
143NOTCH1_21737748_ChIP-Seq_TLL_Human0.84561280
144* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83921707
145* RING1B_27294783_Chip-Seq_ESCs_Mouse0.83280686
146NFYB_21822215_ChIP-Seq_K562_Human0.82999550
147CTBP2_25329375_ChIP-Seq_LNCAP_Human0.82981157
148* TET1_21490601_ChIP-Seq_MESCs_Mouse0.82784049
149* TP53_22573176_ChIP-Seq_HFKS_Human0.82022893
150TBL1_22424771_ChIP-Seq_293T_Human0.80749731
151* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.80457645
152* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.80457645
153CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.80290733
154SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.78806417
155TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76056662
156IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.75236131
157CBP_20019798_ChIP-Seq_JUKART_Human0.75236131
158NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.74782655
159E2F1_20622854_ChIP-Seq_HELA_Human0.73928519
160* RING1B_27294783_Chip-Seq_NPCs_Mouse0.73521994
161* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.72296528
162LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.72204414
163TAF2_19829295_ChIP-Seq_ESCs_Human0.71776640
164SMAD4_21741376_ChIP-Seq_ESCs_Human0.71774937
165KLF5_20875108_ChIP-Seq_MESCs_Mouse0.71650947
166* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70965420

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ6.34092112
2MP0002877_abnormal_melanocyte_morpholog5.54648739
3MP0002909_abnormal_adrenal_gland4.94414869
4* MP0002693_abnormal_pancreas_physiology4.41929560
5MP0009780_abnormal_chondrocyte_physiolo3.96098435
6MP0003195_calcinosis3.85575744
7* MP0001944_abnormal_pancreas_morphology3.68660856
8MP0000678_abnormal_parathyroid_gland3.65996873
9MP0003646_muscle_fatigue3.55137353
10MP0004043_abnormal_pH_regulation3.34883789
11MP0000013_abnormal_adipose_tissue2.90832764
12MP0005451_abnormal_body_composition2.88896352
13MP0000751_myopathy2.83327114
14MP0005379_endocrine/exocrine_gland_phen2.81737548
15MP0002234_abnormal_pharynx_morphology2.52886563
16MP0004145_abnormal_muscle_electrophysio2.45702522
17MP0002106_abnormal_muscle_physiology2.36682021
18* MP0002078_abnormal_glucose_homeostasis2.34530786
19MP0001986_abnormal_taste_sensitivity2.31880882
20MP0006036_abnormal_mitochondrial_physio2.22982770
21MP0005220_abnormal_exocrine_pancreas2.21267192
22MP0004087_abnormal_muscle_fiber2.19319928
23MP0003300_gastrointestinal_ulcer2.11001296
24MP0005330_cardiomyopathy2.09267347
25MP0002896_abnormal_bone_mineralization1.94036208
26MP0008961_abnormal_basal_metabolism1.89597062
27MP0002837_dystrophic_cardiac_calcinosis1.86450540
28MP0004264_abnormal_extraembryonic_tissu1.83373263
29MP0002822_catalepsy1.82378754
30MP0003183_abnormal_peptide_metabolism1.80384039
31MP0002163_abnormal_gland_morphology1.79887847
32MP0003172_abnormal_lysosome_physiology1.79342771
33MP0002108_abnormal_muscle_morphology1.78722364
34MP0000750_abnormal_muscle_regeneration1.78258170
35MP0010386_abnormal_urinary_bladder1.77835378
36MP0004270_analgesia1.76308316
37MP0005620_abnormal_muscle_contractility1.73227122
38MP0000003_abnormal_adipose_tissue1.71204690
39MP0000462_abnormal_digestive_system1.70012551
40MP0002332_abnormal_exercise_endurance1.69750515
41MP0003806_abnormal_nucleotide_metabolis1.63090220
42MP0003045_fibrosis1.56425239
43MP0004036_abnormal_muscle_relaxation1.50986064
44MP0003122_maternal_imprinting1.47789526
45MP0003252_abnormal_bile_duct1.46960638
46MP0002928_abnormal_bile_duct1.46555045
47MP0003868_abnormal_feces_composition1.45726725
48MP0001661_extended_life_span1.45500055
49MP0001765_abnormal_ion_homeostasis1.44900853
50MP0005266_abnormal_metabolism1.38025782
51MP0008004_abnormal_stomach_pH1.37636635
52MP0005187_abnormal_penis_morphology1.33866763
53MP0000733_abnormal_muscle_development1.29747048
54* MP0003953_abnormal_hormone_level1.28781022
55MP0000613_abnormal_salivary_gland1.27172216
56MP0003119_abnormal_digestive_system1.26489912
57MP0005076_abnormal_cell_differentiation1.23631709
58MP0003959_abnormal_lean_body1.23465307
59MP0001270_distended_abdomen1.20362844
60MP0006054_spinal_hemorrhage1.17679761
61MP0002638_abnormal_pupillary_reflex1.12029192
62MP0002269_muscular_atrophy1.10392436
63MP0002972_abnormal_cardiac_muscle1.09906094
64MP0005646_abnormal_pituitary_gland1.09904439
65MP0006072_abnormal_retinal_apoptosis1.07969982
66MP0002971_abnormal_brown_adipose1.07348913
67MP0008877_abnormal_DNA_methylation1.06895241
68MP0002876_abnormal_thyroid_physiology1.06736394
69MP0004215_abnormal_myocardial_fiber1.06224786
70MP0005645_abnormal_hypothalamus_physiol1.05826541
71MP0002127_abnormal_cardiovascular_syste1.04280751
72MP0004858_abnormal_nervous_system1.04185206
73MP0000747_muscle_weakness1.03910888
74MP0002277_abnormal_respiratory_mucosa1.03523607
75MP0004185_abnormal_adipocyte_glucose1.02027826
76MP0005375_adipose_tissue_phenotype1.00908445
77MP0001299_abnormal_eye_distance/0.99818028
78MP0005058_abnormal_lysosome_morphology0.99597133
79MP0005535_abnormal_body_temperature0.98206924
80MP0000428_abnormal_craniofacial_morphol0.95521193
81MP0003866_abnormal_defecation0.95396493
82MP0000631_abnormal_neuroendocrine_gland0.93350075
83MP0009840_abnormal_foam_cell0.91365780
84MP0009046_muscle_twitch0.89402936
85MP0010234_abnormal_vibrissa_follicle0.88394395
86MP0005365_abnormal_bile_salt0.88154560
87MP0009672_abnormal_birth_weight0.87742196
88MP0003121_genomic_imprinting0.87617709
89MP0004084_abnormal_cardiac_muscle0.86666469
90MP0005257_abnormal_intraocular_pressure0.85612043
91MP0005332_abnormal_amino_acid0.83313781
92MP0001666_abnormal_nutrient_absorption0.81210883
93MP0005083_abnormal_biliary_tract0.81182699
94MP0002168_other_aberrant_phenotype0.80785295
95MP0000639_abnormal_adrenal_gland0.78311879
96MP0003787_abnormal_imprinting0.77752922
97MP0004510_myositis0.77661373
98* MP0009643_abnormal_urine_homeostasis0.77156733
99MP0000230_abnormal_systemic_arterial0.76752138
100MP0010630_abnormal_cardiac_muscle0.76064350
101MP0005448_abnormal_energy_balance0.75978522
102MP0002160_abnormal_reproductive_system0.74785941
103MP0005310_abnormal_salivary_gland0.74498252
104MP0004484_altered_response_of0.73929543
105MP0005670_abnormal_white_adipose0.73472528
106MP0001727_abnormal_embryo_implantation0.72261998
107MP0000749_muscle_degeneration0.71429159
108MP0001849_ear_inflammation0.70742682
109MP0002090_abnormal_vision0.70604167
110MP0005452_abnormal_adipose_tissue0.70403174
111MP0009703_decreased_birth_body0.70008327
112MP0000516_abnormal_urinary_system0.69755983
113MP0005367_renal/urinary_system_phenotyp0.69755983
114MP0001756_abnormal_urination0.69404495
115MP0000955_abnormal_spinal_cord0.66548813
116MP0000470_abnormal_stomach_morphology0.62742213
117MP0005636_abnormal_mineral_homeostasis0.61237382
118MP0005248_abnormal_Harderian_gland0.59515188
119MP0001984_abnormal_olfaction0.57259443
120MP0004130_abnormal_muscle_cell0.56639445
121MP0005334_abnormal_fat_pad0.56400851
122MP0001348_abnormal_lacrimal_gland0.56361056
123MP0003566_abnormal_cell_adhesion0.55206792
124MP0002069_abnormal_eating/drinking_beha0.54632250
125MP0000759_abnormal_skeletal_muscle0.54334132
126MP0002177_abnormal_outer_ear0.54176250
127MP0004085_abnormal_heartbeat0.53961676
128MP0002733_abnormal_thermal_nociception0.53535459
129MP0003879_abnormal_hair_cell0.53493931
130MP0003329_amyloid_beta_deposits0.53212243
131MP0004233_abnormal_muscle_weight0.52495370
132MP0003123_paternal_imprinting0.51793896
133MP0002118_abnormal_lipid_homeostasis0.50230754
134MP0005666_abnormal_adipose_tissue0.49801756
135MP0002138_abnormal_hepatobiliary_system0.48864743
136MP0003705_abnormal_hypodermis_morpholog0.48703848
137MP0001502_abnormal_circadian_rhythm0.48357124
138MP0000681_abnormal_thyroid_gland0.47597155
139MP0005369_muscle_phenotype0.46731683
140MP0003633_abnormal_nervous_system0.46711725
141MP0004134_abnormal_chest_morphology0.46562937
142MP0010678_abnormal_skin_adnexa0.46332848
143* MP0009642_abnormal_blood_homeostasis0.46311231
144MP0005385_cardiovascular_system_phenoty0.44764723
145MP0001544_abnormal_cardiovascular_syste0.44764723
146MP0005319_abnormal_enzyme/_coenzyme0.44324012
147MP0002970_abnormal_white_adipose0.43460277

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)8.65599995
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.05092891
3Hypoglycemic seizures (HP:0002173)7.00408691
4Muscle fiber inclusion bodies (HP:0100299)6.88227489
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.62768641
6Insulin-resistant diabetes mellitus (HP:0000831)6.41288504
7Nemaline bodies (HP:0003798)6.38632711
8Pancreatic islet-cell hyperplasia (HP:0004510)6.33135624
9Symptomatic seizures (HP:0011145)6.11219196
10Hypoglycemic coma (HP:0001325)5.98812694
11Abnormality of endocrine pancreas physiology (HP:0012093)5.74398403
12Abnormality of the pancreatic islet cells (HP:0006476)5.74398403
13Large for gestational age (HP:0001520)5.65297796
14Hyperglycemia (HP:0003074)5.41809685
15Muscle hypertrophy of the lower extremities (HP:0008968)5.24509435
16Calf muscle hypertrophy (HP:0008981)5.02291599
17Exercise-induced muscle cramps (HP:0003710)4.94601649
18Ketoacidosis (HP:0001993)4.76410320
19Type 1 muscle fiber predominance (HP:0003803)4.40768262
20Abnormality of calcium-phosphate metabolism (HP:0100530)4.28827516
21EMG: myopathic abnormalities (HP:0003458)4.25051892
22Late onset (HP:0003584)4.19464090
23Distal arthrogryposis (HP:0005684)4.16419606
24Unilateral renal agenesis (HP:0000122)4.12054781
25Myopathic facies (HP:0002058)3.99173109
26Abnormality of the calf musculature (HP:0001430)3.87274597
27Mucopolysacchariduria (HP:0008155)3.72010750
28Urinary glycosaminoglycan excretion (HP:0003541)3.72010750
29Abnormal pancreas size (HP:0012094)3.62131099
30Hyporeflexia of lower limbs (HP:0002600)3.61942810
31Papilledema (HP:0001085)3.58744364
32Insulin resistance (HP:0000855)3.51652323
33Hypokalemia (HP:0002900)3.48223447
34Decreased circulating renin level (HP:0003351)3.45746012
35Prominent metopic ridge (HP:0005487)3.41597799
36Abnormality of mucopolysaccharide metabolism (HP:0011020)3.39603721
37Abnormality of polysaccharide metabolism (HP:0011012)3.39603721
38Abnormality of glycosaminoglycan metabolism (HP:0004371)3.39603721
39Round ear (HP:0100830)3.38117492
40Centrally nucleated skeletal muscle fibers (HP:0003687)3.28073156
41Rhabdomyolysis (HP:0003201)3.25367279
42Rimmed vacuoles (HP:0003805)3.24775162
43Difficulty running (HP:0009046)3.22738731
44Frequent falls (HP:0002359)3.17663261
45Dysostosis multiplex (HP:0000943)3.10266915
46Hyperparathyroidism (HP:0000843)3.08040667
47Abnormality of the metopic suture (HP:0005556)2.93766981
48Conjugated hyperbilirubinemia (HP:0002908)2.84291196
49Neck muscle weakness (HP:0000467)2.80165756
50Abnormality of potassium homeostasis (HP:0011042)2.78866291
51Agitation (HP:0000713)2.72519007
52Hypsarrhythmia (HP:0002521)2.70850050
53Retinal atrophy (HP:0001105)2.69165712
54Malignant hyperthermia (HP:0002047)2.68129948
55Abnormality of renin-angiotensin system (HP:0000847)2.67458475
56Subaortic stenosis (HP:0001682)2.66963328
57Abnormality of the left ventricular outflow tract (HP:0011103)2.66963328
58EEG with generalized epileptiform discharges (HP:0011198)2.66448401
59Congenital malformation of the right heart (HP:0011723)2.65288954
60Double outlet right ventricle (HP:0001719)2.65288954
61Ulnar deviation of the wrist (HP:0003049)2.62367294
62Abnormality of skeletal muscle fiber size (HP:0012084)2.62213306
63Ketosis (HP:0001946)2.57694504
64Increased circulating renin level (HP:0000848)2.55335439
65Muscle fiber splitting (HP:0003555)2.53995105
66Epileptiform EEG discharges (HP:0011182)2.53602834
67Osteomalacia (HP:0002749)2.52318866
68Hyperthyroidism (HP:0000836)2.52202116
69Hypomagnesemia (HP:0002917)2.47118999
70Hyperphosphatemia (HP:0002905)2.45832681
71Type I diabetes mellitus (HP:0100651)2.45315894
72Hypercortisolism (HP:0001578)2.43410980
73Abnormality of the intrinsic pathway (HP:0010989)2.43136555
74Hyperkalemia (HP:0002153)2.38622099
75Proximal amyotrophy (HP:0007126)2.35327536
76Missing ribs (HP:0000921)2.34510234
77Exocrine pancreatic insufficiency (HP:0001738)2.32585974
78Sudden death (HP:0001699)2.31445926
79Calcaneovalgus deformity (HP:0001848)2.30715199
80Skin nodule (HP:0200036)2.30665407
81Generalized aminoaciduria (HP:0002909)2.27790742
82Increased variability in muscle fiber diameter (HP:0003557)2.26787637
83Fetal akinesia sequence (HP:0001989)2.26073035
84Thoracolumbar scoliosis (HP:0002944)2.23507204
85Muscle stiffness (HP:0003552)2.19665322
86Scapular winging (HP:0003691)2.19585295
87Enlarged penis (HP:0000040)2.18524963
88Failure to thrive in infancy (HP:0001531)2.16938961
89Severe short stature (HP:0003510)2.14919249
90Global brain atrophy (HP:0002283)2.12595535
91Asymmetric septal hypertrophy (HP:0001670)2.11835844
92Bulbar palsy (HP:0001283)2.09449310
93Absent phalangeal crease (HP:0006109)2.09354112
94Abnormality of magnesium homeostasis (HP:0004921)2.07912284
95Congenital glaucoma (HP:0001087)2.06555502
96Limb-girdle muscle atrophy (HP:0003797)2.05045354
97Abdominal distention (HP:0003270)2.04038897
98Progressive muscle weakness (HP:0003323)2.03472949
99Downturned corners of mouth (HP:0002714)2.01377001
100Hypophosphatemia (HP:0002148)1.99468839
101Distal lower limb muscle weakness (HP:0009053)1.97995851
102Areflexia of lower limbs (HP:0002522)1.96876290
103Visual hallucinations (HP:0002367)1.96429164
104Macroorchidism (HP:0000053)1.96137361
105Abnormality of the shoulder girdle musculature (HP:0001435)1.94806213
106Deformed tarsal bones (HP:0008119)1.94023418
107Mildly elevated creatine phosphokinase (HP:0008180)1.92764637
108Muscular dystrophy (HP:0003560)1.89444635
109Abnormality of the common coagulation pathway (HP:0010990)1.86468670
110Hypotension (HP:0002615)1.84529003
111Hepatic necrosis (HP:0002605)1.83474427
112Stridor (HP:0010307)1.83042772
113EMG: neuropathic changes (HP:0003445)1.82353759
114Myoglobinuria (HP:0002913)1.79701831
115Sex reversal (HP:0012245)1.79305944
116Abnormal sex determination (HP:0012244)1.79305944
117Hypokinesia (HP:0002375)1.77492683
118Protuberant abdomen (HP:0001538)1.76324213
119Dilated cardiomyopathy (HP:0001644)1.74547749
120Restlessness (HP:0000711)1.73187622
121Fatigable weakness (HP:0003473)1.72777735
122Abnormality of the neuromuscular junction (HP:0003398)1.72777735
123Abnormality of small intestinal villus morphology (HP:0011472)1.71019725
124Villous atrophy (HP:0011473)1.71019725
125Hypothermia (HP:0002045)1.69821279
126Dysautonomia (HP:0002459)1.69280567
127Postural tremor (HP:0002174)1.68617969
128Exercise-induced myalgia (HP:0003738)1.68052365
129Pheochromocytoma (HP:0002666)1.67640798
130Bundle branch block (HP:0011710)1.67267265
131Generalized muscle weakness (HP:0003324)1.67242165
132Limb hypertonia (HP:0002509)1.67144749
133Abnormal finger flexion creases (HP:0006143)1.66955227
134Hyperphosphaturia (HP:0003109)1.65795586
135Cerebral inclusion bodies (HP:0100314)1.65117067
136Turricephaly (HP:0000262)1.64609471
137Bronchomalacia (HP:0002780)1.63751473
138Back pain (HP:0003418)1.63454030
139Weak cry (HP:0001612)1.63073447
140Tongue fasciculations (HP:0001308)1.62907002
141Cerebral aneurysm (HP:0004944)1.62771577
142Hyperactive renin-angiotensin system (HP:0000841)1.62619460
143Cortical visual impairment (HP:0100704)1.61197366
144Menstrual irregularities (HP:0000858)1.61150894
145Abnormality of the musculature of the pelvis (HP:0001469)1.59797334
146Abnormality of the hip-girdle musculature (HP:0001445)1.59797334
147Glucose intolerance (HP:0000833)1.59665770
148Thin bony cortex (HP:0002753)1.59410415
149Difficulty climbing stairs (HP:0003551)1.58815172
150Ventricular fibrillation (HP:0001663)1.58708309
151Shoulder girdle muscle weakness (HP:0003547)1.58224564
152Elevated alkaline phosphatase (HP:0003155)1.58164139
153Testicular neoplasm (HP:0010788)1.57937289
154Gowers sign (HP:0003391)1.57144491
155Adrenal overactivity (HP:0002717)1.54713469
156Muscle fibrillation (HP:0010546)1.53190011
157Tetany (HP:0001281)1.52834629
158Muscular hypotonia of the trunk (HP:0008936)1.51028776
159Abnormality of alkaline phosphatase activity (HP:0004379)1.48996588
160Ankyloglossia (HP:0010296)1.48201856
161Generalized hyperpigmentation (HP:0007440)1.48022868
162Progressive neurologic deterioration (HP:0002344)1.46936145
163Insomnia (HP:0100785)1.46700527
164Resting tremor (HP:0002322)1.45264672
165Intrahepatic cholestasis (HP:0001406)1.44973970

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN8.09685786
2INSRR7.42113059
3PASK5.89028090
4TAOK35.15592497
5PINK14.32841442
6HIPK23.32579061
7TTN2.90631019
8PRKD32.84648470
9MAP3K22.69189503
10MAPK152.60365596
11TRIB32.49933493
12SCYL22.29462906
13PDGFRA2.24854293
14FGFR22.20041754
15ERN12.19828867
16FRK1.93003715
17UHMK11.90699261
18MUSK1.86940659
19PRKCH1.74057124
20PTK61.70781852
21NTRK31.69113599
22SIK11.64783718
23DAPK21.60186905
24TRPM71.54711929
25FLT31.53845831
26NTRK11.53425672
27CAMKK21.45455402
28IRAK31.45325609
29MAP3K91.36301079
30CDC42BPA1.34582570
31WNK41.32403159
32STK161.26813736
33PTK21.24539040
34MAP2K61.23720836
35PRKD21.22855004
36DYRK1B1.17205319
37MAP3K71.15039819
38BRSK21.14924759
39STK38L1.13303209
40NME11.09895202
41RET1.05757570
42ALK1.02016271
43JAK20.98776521
44KSR20.97715005
45MAPK120.95152503
46MAP3K100.95077210
47EPHA30.93550474
48LATS10.89233051
49PKN20.88134839
50PRKAA10.86558607
51ICK0.84857155
52MET0.84439715
53CSNK1G10.83631335
54MAPKAPK30.81586490
55LMTK20.81233112
56MARK30.77332440
57JAK10.75743335
58CAMKK10.74341476
59MARK20.73746958
60PRKD10.70673307
61EEF2K0.69355515
62WNK10.68856275
63CSNK1G30.68746298
64CAMK2G0.66240672
65PAK30.65945360
66RIPK10.65271805
67PDGFRB0.63588002
68CAMK1G0.61807808
69IRAK20.61200993
70FER0.61131090
71IRAK10.61045873
72AKT20.61005587
73MTOR0.60884544
74LATS20.59360930
75SGK20.58543585
76MAP2K20.58311612
77NLK0.58301819
78NME20.57243537
79STK30.56815933
80CAMK2D0.52548984
81MAPK110.51898246
82* MAP3K10.51890361
83ITK0.51439135
84GSK3A0.50812124
85CSNK1G20.48015768
86MOS0.47887321
87FGFR30.46786519
88FGFR40.46739341
89PRKACG0.46502814
90MAP2K40.46327655
91CDK120.45567638
92PRKG20.44566515
93ROCK10.44361533
94MAP2K70.43892464
95CCNB10.42967961
96BMPR1B0.42583026
97STK240.42434645
98EPHB10.42375328
99PHKG10.41222316
100PHKG20.41222316
101DMPK0.40592504
102SGK2230.40257286
103SGK4940.40257286
104WNK30.39023274
105PRKCI0.36926491
106ADRBK10.36242986
107ERBB30.36063310
108PRKG10.35966828
109GRK10.35303579
110RPS6KA20.34769764
111PRKDC0.34534910
112BRSK10.34005612
113TAOK10.33867826
114STK110.33286160
115DAPK30.33263621
116CDK50.33152541
117CAMK10.33133708
118AKT30.32830532
119PRKCE0.32601221
120CDK30.32583823
121MAP3K30.32210476
122MAP2K30.32170821
123ADRBK20.32138459
124LIMK10.31476927
125GRK50.31365594
126IGF1R0.31006562
127PIK3CG0.30831577
128RPS6KA30.30652355
129PRKACA0.30198099
130CAMK2B0.30182209
131PNCK0.30013844
132MAP2K10.28972137
133BCKDK0.28616700
134MST40.27852778
135PRKCG0.26440106
136EIF2AK30.26313703
137ABL20.25341694
138CSNK1A1L0.24660389
139RPS6KB10.24657566
140CSNK1A10.24531153
141PAK60.23852484
142* MAPK140.23829382
143SGK30.23126082
144PDK10.22376919
145EGFR0.21206661
146STK40.21051675
147PRKCA0.20242865
148PDPK10.20182444
149SMG10.19740355
150GSK3B0.18790021
151JAK30.18644900
152PRKAA20.18624148
153CAMK2A0.18135997
154BRD40.17761394
155PRKCB0.17474890
156SGK10.17203645
157MAPK90.17162667
158MAPK100.17081715
159ROCK20.16906934
160CHUK0.16689789
161BRAF0.16487541
162CSNK1D0.15921093
163PRKACB0.15844972

Predicted pathways (KEGG)

RankGene SetZ-score
1* Maturity onset diabetes of the young_Homo sapiens_hsa049508.46461434
2Insulin secretion_Homo sapiens_hsa049113.63049666
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.22581843
4Type I diabetes mellitus_Homo sapiens_hsa049403.15230077
5Protein export_Homo sapiens_hsa030603.12253801
6* Type II diabetes mellitus_Homo sapiens_hsa049302.84750586
7Sulfur metabolism_Homo sapiens_hsa009202.43911942
8Regulation of autophagy_Homo sapiens_hsa041402.32399833
9Cardiac muscle contraction_Homo sapiens_hsa042602.11101526
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.05202398
11Pancreatic secretion_Homo sapiens_hsa049721.76074625
12Fatty acid elongation_Homo sapiens_hsa000621.69692060
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61511958
14Cocaine addiction_Homo sapiens_hsa050301.61498035
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60600087
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49226196
17Insulin resistance_Homo sapiens_hsa049311.46103792
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.45321808
19Fructose and mannose metabolism_Homo sapiens_hsa000511.44357655
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43470902
21Selenocompound metabolism_Homo sapiens_hsa004501.40134769
22Fatty acid metabolism_Homo sapiens_hsa012121.35266925
23Lysosome_Homo sapiens_hsa041421.31911140
24N-Glycan biosynthesis_Homo sapiens_hsa005101.31380720
25Glucagon signaling pathway_Homo sapiens_hsa049221.30156837
26Oxidative phosphorylation_Homo sapiens_hsa001901.29882195
27Fatty acid degradation_Homo sapiens_hsa000711.24174016
28Vibrio cholerae infection_Homo sapiens_hsa051101.23768927
29Amphetamine addiction_Homo sapiens_hsa050311.21882497
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15012657
31mTOR signaling pathway_Homo sapiens_hsa041501.14125407
32Folate biosynthesis_Homo sapiens_hsa007901.13883442
33ABC transporters_Homo sapiens_hsa020101.13573856
34Taste transduction_Homo sapiens_hsa047421.12858814
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09449077
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04774530
37Cholinergic synapse_Homo sapiens_hsa047251.03567009
38Long-term potentiation_Homo sapiens_hsa047201.03350250
39beta-Alanine metabolism_Homo sapiens_hsa004101.01624970
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00787120
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00627794
42Prolactin signaling pathway_Homo sapiens_hsa049171.00360476
43Dorso-ventral axis formation_Homo sapiens_hsa043200.99893956
44Thyroid hormone synthesis_Homo sapiens_hsa049180.98452028
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98248362
46Pentose phosphate pathway_Homo sapiens_hsa000300.98056910
47Estrogen signaling pathway_Homo sapiens_hsa049150.96811467
48Collecting duct acid secretion_Homo sapiens_hsa049660.95329863
49Dopaminergic synapse_Homo sapiens_hsa047280.93561808
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92831495
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92253106
52Alzheimers disease_Homo sapiens_hsa050100.92012903
53Insulin signaling pathway_Homo sapiens_hsa049100.87201329
54Parkinsons disease_Homo sapiens_hsa050120.84615504
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84525009
56Arginine and proline metabolism_Homo sapiens_hsa003300.83787520
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83365699
58GABAergic synapse_Homo sapiens_hsa047270.83179801
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82574971
60Renin secretion_Homo sapiens_hsa049240.81608006
61Prion diseases_Homo sapiens_hsa050200.81294156
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79795160
63Carbon metabolism_Homo sapiens_hsa012000.79456083
64Fat digestion and absorption_Homo sapiens_hsa049750.77219930
65Circadian entrainment_Homo sapiens_hsa047130.76551085
66Propanoate metabolism_Homo sapiens_hsa006400.74973590
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.74436457
68FoxO signaling pathway_Homo sapiens_hsa040680.73595226
69Circadian rhythm_Homo sapiens_hsa047100.73172577
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72799364
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69978997
72Mineral absorption_Homo sapiens_hsa049780.69612899
73Peroxisome_Homo sapiens_hsa041460.69102321
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68913401
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68678351
76Gap junction_Homo sapiens_hsa045400.67145191
77Bladder cancer_Homo sapiens_hsa052190.66518402
78Protein digestion and absorption_Homo sapiens_hsa049740.66106006
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65666880
80Arginine biosynthesis_Homo sapiens_hsa002200.64353924
81Synaptic vesicle cycle_Homo sapiens_hsa047210.64127413
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63263609
83Serotonergic synapse_Homo sapiens_hsa047260.62298761
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61925880
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61072115
86Thyroid cancer_Homo sapiens_hsa052160.60400650
87Gastric acid secretion_Homo sapiens_hsa049710.59117526
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58176527
89AMPK signaling pathway_Homo sapiens_hsa041520.57956755
90Starch and sucrose metabolism_Homo sapiens_hsa005000.57919315
91Pyruvate metabolism_Homo sapiens_hsa006200.56678405
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.54394440
93Tryptophan metabolism_Homo sapiens_hsa003800.53472509
94Melanogenesis_Homo sapiens_hsa049160.52940279
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52616634
96cAMP signaling pathway_Homo sapiens_hsa040240.52455780
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51743554
98Morphine addiction_Homo sapiens_hsa050320.51630541
99Dilated cardiomyopathy_Homo sapiens_hsa054140.51436110
100Lysine degradation_Homo sapiens_hsa003100.51287849
101Renal cell carcinoma_Homo sapiens_hsa052110.51142351
102Inositol phosphate metabolism_Homo sapiens_hsa005620.50890810
103GnRH signaling pathway_Homo sapiens_hsa049120.50104415
104Nitrogen metabolism_Homo sapiens_hsa009100.50094294
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48916965
106Chronic myeloid leukemia_Homo sapiens_hsa052200.48816370
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48330341
108Galactose metabolism_Homo sapiens_hsa000520.46683722
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45933755
110Glutamatergic synapse_Homo sapiens_hsa047240.45169678
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.44167345
112Tight junction_Homo sapiens_hsa045300.43968423
113Purine metabolism_Homo sapiens_hsa002300.43482090
114Prostate cancer_Homo sapiens_hsa052150.43343657
115Endometrial cancer_Homo sapiens_hsa052130.42103293
116Glioma_Homo sapiens_hsa052140.41995657
117Other glycan degradation_Homo sapiens_hsa005110.41957636
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41221382
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40747355
120Sulfur relay system_Homo sapiens_hsa041220.39827230
121Sphingolipid metabolism_Homo sapiens_hsa006000.38474922
122Long-term depression_Homo sapiens_hsa047300.37484793
123Alcoholism_Homo sapiens_hsa050340.37465812
124Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37355661
125Ovarian steroidogenesis_Homo sapiens_hsa049130.36956997
126Linoleic acid metabolism_Homo sapiens_hsa005910.36114026
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35893005
128Oocyte meiosis_Homo sapiens_hsa041140.35368886
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.34662538
130Oxytocin signaling pathway_Homo sapiens_hsa049210.34636155
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34425466
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33786805
133Butanoate metabolism_Homo sapiens_hsa006500.33362556
134Metabolic pathways_Homo sapiens_hsa011000.33359619
135Bile secretion_Homo sapiens_hsa049760.32395722
136VEGF signaling pathway_Homo sapiens_hsa043700.31899760
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31739592
138Adherens junction_Homo sapiens_hsa045200.31327277
139Calcium signaling pathway_Homo sapiens_hsa040200.30563335
140Vitamin B6 metabolism_Homo sapiens_hsa007500.28887596
141Salivary secretion_Homo sapiens_hsa049700.27677503

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