MAFB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of interleukin-12 production (GO:0032695)5.18269640
2modulation by symbiont of host defense response (GO:0052031)4.65619934
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.65619934
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.65619934
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.65619934
6modulation by symbiont of host immune response (GO:0052553)4.65619934
7positive regulation by symbiont of host defense response (GO:0052509)4.65619934
8regulation of interferon-beta biosynthetic process (GO:0045357)4.54541190
9regulation of mononuclear cell migration (GO:0071675)4.53678965
10microglial cell activation (GO:0001774)4.45975301
11complement activation, alternative pathway (GO:0006957)4.06820156
12oligosaccharide catabolic process (GO:0009313)4.06161894
13cellular response to thyroid hormone stimulus (GO:0097067)3.98017380
14L-alpha-amino acid transmembrane transport (GO:1902475)3.95773372
15macrophage activation involved in immune response (GO:0002281)3.89610862
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.72728658
17lipopolysaccharide-mediated signaling pathway (GO:0031663)3.72625167
18positive regulation of mast cell activation (GO:0033005)3.71801995
19L-phenylalanine catabolic process (GO:0006559)3.67700490
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.67700490
21positive regulation of mast cell degranulation (GO:0043306)3.66924807
22positive regulation of mast cell activation involved in immune response (GO:0033008)3.66924807
23production of molecular mediator involved in inflammatory response (GO:0002532)3.65807263
24macrophage activation (GO:0042116)3.62583606
25regulation of mast cell degranulation (GO:0043304)3.61580028
26peptidyl-glutamic acid carboxylation (GO:0017187)3.59934860
27protein carboxylation (GO:0018214)3.59934860
28amino sugar catabolic process (GO:0046348)3.58478815
29positive regulation of gamma-delta T cell activation (GO:0046645)3.56532356
30negative regulation of granulocyte differentiation (GO:0030853)3.53804081
31positive regulation of leukocyte degranulation (GO:0043302)3.48890731
32phospholipid efflux (GO:0033700)3.46020653
33glycolipid catabolic process (GO:0019377)3.43574681
34detection of other organism (GO:0098543)3.43443503
35N-acetylneuraminate metabolic process (GO:0006054)3.39043133
36negative regulation of cell killing (GO:0031342)3.38705333
37negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.38705333
38immunoglobulin mediated immune response (GO:0016064)3.37358710
39regulation of mast cell activation involved in immune response (GO:0033006)3.35989490
40positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.35512463
41erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.33405735
42L-phenylalanine metabolic process (GO:0006558)3.33405735
43positive regulation of chemokine biosynthetic process (GO:0045080)3.33059136
44positive regulation of chemokine secretion (GO:0090197)3.29837537
45regulation of leukocyte degranulation (GO:0043300)3.27990977
46T-helper 1 type immune response (GO:0042088)3.26093025
47detection of external biotic stimulus (GO:0098581)3.25379602
48regulation of mast cell activation (GO:0033003)3.21601905
49Golgi transport vesicle coating (GO:0048200)3.20870975
50COPI coating of Golgi vesicle (GO:0048205)3.20870975
51granulocyte activation (GO:0036230)3.18680900
52apoptotic cell clearance (GO:0043277)3.14251242
53positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.13838877
54complement activation (GO:0006956)3.12229970
55regulation of myeloid leukocyte mediated immunity (GO:0002886)3.11166087
56detection of biotic stimulus (GO:0009595)3.10897309
57response to thyroid hormone (GO:0097066)3.10731159
58ceramide catabolic process (GO:0046514)3.08212818
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.07344690
60complement activation, classical pathway (GO:0006958)3.04190752
61regulation of protein activation cascade (GO:2000257)3.02104473
62regulation of complement activation (GO:0030449)3.00583438
63detection of bacterium (GO:0016045)3.00470761
64positive regulation of interferon-alpha production (GO:0032727)2.99888834
65mannose metabolic process (GO:0006013)2.98202831
66membrane lipid catabolic process (GO:0046466)2.98104697
67regulation of vitamin D biosynthetic process (GO:0060556)2.97613237
68regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.97065872
69negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.94922746
70myeloid cell activation involved in immune response (GO:0002275)2.93798008
71neutrophil activation (GO:0042119)2.92339334
72urea metabolic process (GO:0019627)2.92096497
73urea cycle (GO:0000050)2.92096497
74positive regulation of monocyte chemotaxis (GO:0090026)2.90293009
75positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.89778463
76positive regulation of antigen processing and presentation (GO:0002579)2.89250442
77positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.89004037
78regulation of podosome assembly (GO:0071801)2.86996499
79G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.86632893
80hyaluronan catabolic process (GO:0030214)2.85162194
81cellular response to arsenic-containing substance (GO:0071243)2.84911482
82response to host immune response (GO:0052572)2.82875208
83response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.82875208
84sphingolipid catabolic process (GO:0030149)2.82707316
85response to muramyl dipeptide (GO:0032495)2.82098158
86regulation of interferon-alpha production (GO:0032647)2.81734203
87regulation of cholesterol storage (GO:0010885)2.81420820
88phagosome maturation (GO:0090382)2.81242760
89regulation of cholesterol esterification (GO:0010872)2.80023066
90negative regulation of interleukin-1 beta production (GO:0032691)2.79624489
91regulation of gamma-delta T cell activation (GO:0046643)2.79179681
92keratan sulfate catabolic process (GO:0042340)2.78962366
93aromatic amino acid family catabolic process (GO:0009074)2.78778046
94positive regulation of cellular amide metabolic process (GO:0034250)2.77213115
95positive regulation of heat generation (GO:0031652)2.76688260
96reverse cholesterol transport (GO:0043691)2.75532704
97negative regulation of cytokine production involved in immune response (GO:0002719)2.75367494
98regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.73193114
99regulation of chemokine biosynthetic process (GO:0045073)2.72181370
100plasma lipoprotein particle clearance (GO:0034381)2.72170920
101cholesterol efflux (GO:0033344)2.71591839
102basic amino acid transport (GO:0015802)2.71559317
103regulation of regulated secretory pathway (GO:1903305)2.70838883
104regulation of interleukin-8 biosynthetic process (GO:0045414)2.70153777
105peptide hormone processing (GO:0016486)2.69516341
106monocyte chemotaxis (GO:0002548)2.67556151
107germinal center formation (GO:0002467)2.67102603
108neutrophil chemotaxis (GO:0030593)2.66934524
109negative regulation of bone resorption (GO:0045779)2.66912571
110fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.66663141
111protein activation cascade (GO:0072376)2.64747754
112positive regulation of interleukin-6 production (GO:0032755)2.64013532
113nitrogen cycle metabolic process (GO:0071941)2.62409832
114macrophage differentiation (GO:0030225)2.61196788
115positive regulation of regulated secretory pathway (GO:1903307)2.60983544
116detection of molecule of bacterial origin (GO:0032490)2.59948418
117neutrophil migration (GO:1990266)2.59612933
118interferon-gamma-mediated signaling pathway (GO:0060333)2.59231997
119positive regulation of p38MAPK cascade (GO:1900745)2.58708863
120response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.58353583
121response to host (GO:0075136)2.58353583
122response to host defenses (GO:0052200)2.58353583
123high-density lipoprotein particle remodeling (GO:0034375)2.57385436
124neutrophil activation involved in immune response (GO:0002283)2.56908077
125regulation of macrophage chemotaxis (GO:0010758)2.52906960
126adenosine receptor signaling pathway (GO:0001973)2.52670278
127negative regulation of interleukin-17 production (GO:0032700)2.52635060
128maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.52614026
129lysosome organization (GO:0007040)2.52250876
130lytic vacuole organization (GO:0080171)2.52250876
131regulation of membrane protein ectodomain proteolysis (GO:0051043)2.51982555
132regulation of interleukin-6 production (GO:0032675)2.51354444
133negative regulation of digestive system process (GO:0060457)2.50819693
134granulocyte chemotaxis (GO:0071621)2.50202124
135negative regulation of interleukin-1 production (GO:0032692)2.49968479
136regulation of T-helper 2 cell differentiation (GO:0045628)2.49230981
137positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.49119358
138regulation of dendritic cell antigen processing and presentation (GO:0002604)2.48063472
139bile acid and bile salt transport (GO:0015721)2.47839184
140I-kappaB phosphorylation (GO:0007252)2.47485011
141regulation of fever generation (GO:0031620)2.46415768
142response to peptidoglycan (GO:0032494)2.44087682
143hydrogen peroxide biosynthetic process (GO:0050665)2.43803492
144lipoprotein metabolic process (GO:0042157)2.43750598
145regulation of antigen processing and presentation (GO:0002577)2.43701556
146negative regulation of tissue remodeling (GO:0034104)2.42611998
147respiratory burst (GO:0045730)2.41029513
148regulation of chemokine secretion (GO:0090196)2.40735655
149glomerular visceral epithelial cell development (GO:0072015)2.39907583
150alpha-linolenic acid metabolic process (GO:0036109)2.39798051
151plasma lipoprotein particle remodeling (GO:0034369)2.38820441
152protein-lipid complex remodeling (GO:0034368)2.38820441
153macromolecular complex remodeling (GO:0034367)2.38820441
154positive regulation of glycolytic process (GO:0045821)2.38084540
155regulation of B cell receptor signaling pathway (GO:0050855)2.34897778
156plasma lipoprotein particle assembly (GO:0034377)2.34815548
157regulation of apoptotic cell clearance (GO:2000425)2.34774379
158positive regulation of cholesterol efflux (GO:0010875)2.34710415
159endocrine pancreas development (GO:0031018)2.34403301
160phospholipid homeostasis (GO:0055091)2.33649327
161negative regulation of fibrinolysis (GO:0051918)2.32980081
162regulation of triglyceride catabolic process (GO:0010896)2.32942716
163protein-lipid complex assembly (GO:0065005)2.32828823
164positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.32439165
165fibrinolysis (GO:0042730)2.31642221
166positive regulation of sterol transport (GO:0032373)2.31089301
167positive regulation of cholesterol transport (GO:0032376)2.31089301
168protein retention in ER lumen (GO:0006621)2.28433168
169glycosphingolipid catabolic process (GO:0046479)2.27696396
170acylglycerol homeostasis (GO:0055090)2.25873694
171triglyceride homeostasis (GO:0070328)2.25873694
172cellular extravasation (GO:0045123)2.25147389

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.79990570
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.08214743
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.78360869
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.38729290
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.32990098
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.17378907
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.12683704
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.07068792
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.99699261
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.86982559
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.42628898
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.38752556
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.35454010
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35443257
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.08428850
16* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.93431897
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87809285
18ESR1_21235772_ChIP-Seq_MCF-7_Human1.84511900
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84006106
20* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.82753500
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.78788830
22SPI1_23547873_ChIP-Seq_NB4_Human1.78370637
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73923096
24CLOCK_20551151_ChIP-Seq_293T_Human1.73530135
25VDR_21846776_ChIP-Seq_THP-1_Human1.70205167
26GATA1_22025678_ChIP-Seq_K562_Human1.66097630
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57916870
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.54989666
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.53665467
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50451696
31VDR_24787735_ChIP-Seq_THP-1_Human1.46824599
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44576310
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.44316757
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44109470
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.44012328
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43881479
37SPI1_23127762_ChIP-Seq_K562_Human1.43832507
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.37698601
39TFEB_21752829_ChIP-Seq_HELA_Human1.32717842
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32168127
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.31704747
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30968886
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.27225188
44PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26753855
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.26004028
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25606217
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25563327
48LXR_22292898_ChIP-Seq_THP-1_Human1.24713592
49STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23124443
50* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22907887
51PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19494986
52SOX2_20726797_ChIP-Seq_SW620_Human1.18957681
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17770087
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17693143
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17135356
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16167818
57GATA1_19941826_ChIP-Seq_K562_Human1.15270991
58* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14468072
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13970299
60FOXA2_19822575_ChIP-Seq_HepG2_Human1.13881024
61SCL_19346495_ChIP-Seq_HPC-7_Human1.11448732
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11235292
63RUNX_20019798_ChIP-Seq_JUKART_Human1.09954786
64IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07402547
65TRIM28_21343339_ChIP-Seq_HEK293_Human1.07333784
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07105510
67SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06426864
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.06292230
69WT1_19549856_ChIP-ChIP_CCG9911_Human1.05575837
70NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04249893
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04210149
72KDM2B_26808549_Chip-Seq_DND41_Human1.03037359
73MAF_26560356_Chip-Seq_TH1_Human1.02485296
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01649058
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01488939
76SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01399910
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00872694
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00006580
79EGR1_19374776_ChIP-ChIP_THP-1_Human0.98822735
80FOXO3_23340844_ChIP-Seq_DLD1_Human0.98112494
81CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97816861
82* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97795394
83GATA2_19941826_ChIP-Seq_K562_Human0.97657929
84CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97529857
85CDX2_20551321_ChIP-Seq_CACO-2_Human0.95769940
86* PU_27001747_Chip-Seq_BMDM_Mouse0.95476737
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95448446
88IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94382886
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93431234
90NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93101044
91GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93086250
92VDR_24763502_ChIP-Seq_THP-1_Human0.92603656
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92235111
94* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91857353
95STAT1_20625510_ChIP-Seq_HELA_Human0.91819387
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91534726
97* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90648069
98FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87567719
99IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.87396010
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87103850
101GATA4_25053715_ChIP-Seq_YYC3_Human0.86705145
102CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86646050
103KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86628311
104KDM2B_26808549_Chip-Seq_K562_Human0.85091775
105GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84923833
106TCF7_22412390_ChIP-Seq_EML_Mouse0.84573713
107CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84421584
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.84294601
109SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83387390
110GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82736834
111KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82649787
112CJUN_26792858_Chip-Seq_BT549_Human0.82168355
113TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.81833097
114PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81640637
115* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79979565
116MYB_26560356_Chip-Seq_TH2_Human0.79951403
117NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79498393
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79498393
119TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.78368233
120GATA1_19941827_ChIP-Seq_MEL_Mouse0.78139270
121EGR1_19032775_ChIP-ChIP_M12_Human0.78015441
122KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77721805
123UTX_26944678_Chip-Seq_JUKART_Human0.76781029
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75995325
125FOXA1_25552417_ChIP-Seq_VCAP_Human0.75834594
126GATA3_27048872_Chip-Seq_THYMUS_Human0.75237994
127CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.75078322
128GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74789157
129BCOR_27268052_Chip-Seq_Bcells_Human0.74562692
130SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.71933223
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.71920284
132FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.70735165

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.89832854
2MP0009840_abnormal_foam_cell3.56155105
3MP0003191_abnormal_cellular_cholesterol3.41960246
4MP0003183_abnormal_peptide_metabolism3.31764737
5MP0005360_urolithiasis3.14644394
6MP0002139_abnormal_hepatobiliary_system3.13316476
7MP0003195_calcinosis2.99539847
8MP0005365_abnormal_bile_salt2.93724075
9MP0005085_abnormal_gallbladder_physiolo2.56493847
10MP0003252_abnormal_bile_duct2.50989254
11MP0003300_gastrointestinal_ulcer2.47326082
12MP0003172_abnormal_lysosome_physiology2.47012472
13MP0009785_altered_susceptibility_to2.46261739
14MP0006082_CNS_inflammation2.45620312
15MP0003724_increased_susceptibility_to2.44741678
16MP0000013_abnormal_adipose_tissue2.43513930
17MP0003303_peritoneal_inflammation2.37850425
18MP0002138_abnormal_hepatobiliary_system2.30482921
19MP0003436_decreased_susceptibility_to2.21475439
20MP0005670_abnormal_white_adipose2.01700688
21MP0005167_abnormal_blood-brain_barrier2.00381592
22MP0008875_abnormal_xenobiotic_pharmacok1.98795061
23MP0002419_abnormal_innate_immunity1.93787483
24MP0001835_abnormal_antigen_presentation1.93045060
25MP0010329_abnormal_lipoprotein_level1.92714774
26MP0009764_decreased_sensitivity_to1.81757331
27MP0004019_abnormal_vitamin_homeostasis1.81035906
28MP0001533_abnormal_skeleton_physiology1.72659797
29MP0009278_abnormal_bone_marrow1.69547904
30MP0010368_abnormal_lymphatic_system1.69191113
31MP0002837_dystrophic_cardiac_calcinosis1.68404885
32MP0003828_pulmonary_edema1.62659120
33MP0003690_abnormal_glial_cell1.57658388
34MP0003075_altered_response_to1.52659606
35MP0001853_heart_inflammation1.52104910
36MP0005464_abnormal_platelet_physiology1.51867058
37MP0002148_abnormal_hypersensitivity_rea1.50456597
38MP0005257_abnormal_intraocular_pressure1.50112682
39MP0000609_abnormal_liver_physiology1.47661776
40MP0008469_abnormal_protein_level1.45785237
41MP0009643_abnormal_urine_homeostasis1.42561408
42MP0000003_abnormal_adipose_tissue1.42347527
43MP0005000_abnormal_immune_tolerance1.40737475
44MP0002254_reproductive_system_inflammat1.34936909
45MP0002693_abnormal_pancreas_physiology1.34199614
46MP0010234_abnormal_vibrissa_follicle1.33519240
47MP0005387_immune_system_phenotype1.33431102
48MP0001790_abnormal_immune_system1.33431102
49MP0002118_abnormal_lipid_homeostasis1.32119774
50MP0002909_abnormal_adrenal_gland1.30775793
51MP0003705_abnormal_hypodermis_morpholog1.29791410
52MP0005397_hematopoietic_system_phenotyp1.25990751
53MP0001545_abnormal_hematopoietic_system1.25990751
54MP0002998_abnormal_bone_remodeling1.25567194
55MP0000604_amyloidosis1.25369566
56MP0004130_abnormal_muscle_cell1.24572534
57MP0008004_abnormal_stomach_pH1.22423369
58MP0001666_abnormal_nutrient_absorption1.22220005
59MP0001845_abnormal_inflammatory_respons1.20936705
60MP0004947_skin_inflammation1.20034065
61MP0010155_abnormal_intestine_physiology1.19975587
62MP0005025_abnormal_response_to1.19183740
63MP0008438_abnormal_cutaneous_collagen1.18981368
64MP0003448_altered_tumor_morphology1.18498001
65MP0003656_abnormal_erythrocyte_physiolo1.17893703
66* MP0005332_abnormal_amino_acid1.14227144
67MP0000920_abnormal_myelination1.13232547
68MP0005375_adipose_tissue_phenotype1.11779038
69MP0002078_abnormal_glucose_homeostasis1.11332579
70MP0002452_abnormal_antigen_presenting1.10679069
71MP0002928_abnormal_bile_duct1.10450275
72MP0002277_abnormal_respiratory_mucosa1.10036791
73MP0001851_eye_inflammation1.09236350
74MP0005451_abnormal_body_composition1.08507837
75MP0003329_amyloid_beta_deposits1.08440188
76MP0008260_abnormal_autophagy1.08257515
77MP0000343_altered_response_to1.06912245
78MP0000858_altered_metastatic_potential1.05011638
79MP0000465_gastrointestinal_hemorrhage1.03310587
80MP0006054_spinal_hemorrhage1.02745457
81* MP0001756_abnormal_urination1.02520698
82MP0002723_abnormal_immune_serum1.02178686
83MP0004510_myositis1.01200304
84MP0003566_abnormal_cell_adhesion1.00912802
85MP0005164_abnormal_response_to0.99852275
86MP0005220_abnormal_exocrine_pancreas0.99406030
87MP0008961_abnormal_basal_metabolism0.96942230
88MP0005319_abnormal_enzyme/_coenzyme0.96006527
89MP0001800_abnormal_humoral_immune0.94129011
90MP0002090_abnormal_vision0.93671805
91MP0010386_abnormal_urinary_bladder0.93028267
92* MP0001944_abnormal_pancreas_morphology0.92837940
93MP0005166_decreased_susceptibility_to0.92034782
94MP0002933_joint_inflammation0.91961065
95MP0009763_increased_sensitivity_to0.91384113
96MP0002971_abnormal_brown_adipose0.91161324
97MP0005671_abnormal_response_to0.91113695
98MP0005379_endocrine/exocrine_gland_phen0.91053426
99MP0000716_abnormal_immune_system0.90496115
100* MP0002136_abnormal_kidney_physiology0.89986940
101MP0009333_abnormal_splenocyte_physiolog0.89804392
102MP0005334_abnormal_fat_pad0.88646336
103MP0005645_abnormal_hypothalamus_physiol0.88035551
104MP0003795_abnormal_bone_structure0.87776853
105MP0005083_abnormal_biliary_tract0.87179756
106MP0002896_abnormal_bone_mineralization0.85504240
107MP0005390_skeleton_phenotype0.84824650
108MP0002877_abnormal_melanocyte_morpholog0.83794724
109* MP0009642_abnormal_blood_homeostasis0.83509699
110MP0000685_abnormal_immune_system0.82492064
111MP0005084_abnormal_gallbladder_morpholo0.82386575
112MP0003806_abnormal_nucleotide_metabolis0.81251430
113MP0005275_abnormal_skin_tensile0.80962015
114MP0004883_abnormal_blood_vessel0.80251868
115MP0000230_abnormal_systemic_arterial0.79952183
116MP0005310_abnormal_salivary_gland0.78036158
117MP0000598_abnormal_liver_morphology0.77943736
118MP0001819_abnormal_immune_cell0.77882589
119MP0005584_abnormal_enzyme/coenzyme_acti0.77687230
120MP0002420_abnormal_adaptive_immunity0.75956159
121MP0000249_abnormal_blood_vessel0.75878579
122MP0000767_abnormal_smooth_muscle0.75773432
123MP0000678_abnormal_parathyroid_gland0.75705381
124MP0004185_abnormal_adipocyte_glucose0.75610406
125MP0005647_abnormal_sex_gland0.74750706
126MP0002405_respiratory_system_inflammati0.74717648
127MP0003453_abnormal_keratinocyte_physiol0.73997027
128MP0005165_increased_susceptibility_to0.71773805
129MP0005535_abnormal_body_temperature0.70238126
130* MP0003633_abnormal_nervous_system0.67151406
131MP0003879_abnormal_hair_cell0.66723078
132MP0000689_abnormal_spleen_morphology0.66039103
133MP0002332_abnormal_exercise_endurance0.65889553
134MP0003634_abnormal_glial_cell0.65824722
135MP0001542_abnormal_bone_strength0.63483240
136MP0000015_abnormal_ear_pigmentation0.63480398
137MP0002429_abnormal_blood_cell0.60922971
138MP0000371_diluted_coat_color0.56288945

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)8.47129567
2Glomerulonephritis (HP:0000099)7.27769069
3Complement deficiency (HP:0004431)6.69065563
4Abnormality of complement system (HP:0005339)5.58800104
5Dysostosis multiplex (HP:0000943)5.00575981
6Retinal atrophy (HP:0001105)4.42028673
7Vacuolated lymphocytes (HP:0001922)4.19180815
8Urinary glycosaminoglycan excretion (HP:0003541)4.19160162
9Mucopolysacchariduria (HP:0008155)4.19160162
10Abnormality of glycolipid metabolism (HP:0010969)4.13138119
11Abnormality of liposaccharide metabolism (HP:0010968)4.13138119
12Abnormality of glycosphingolipid metabolism (HP:0004343)4.13138119
13Nephritis (HP:0000123)4.11582791
14Abnormality of polysaccharide metabolism (HP:0011012)3.96330460
15Abnormality of glycosaminoglycan metabolism (HP:0004371)3.96330460
16Abnormality of mucopolysaccharide metabolism (HP:0011020)3.96330460
17Recurrent gram-negative bacterial infections (HP:0005420)3.89885859
18Increased cerebral lipofuscin (HP:0011813)3.83665334
19Hypoglycemic seizures (HP:0002173)3.75714018
20Hypoglycemic coma (HP:0001325)3.70768339
21Stomatitis (HP:0010280)3.60091411
22Abnormality of aromatic amino acid family metabolism (HP:0004338)3.52652813
23Xanthomatosis (HP:0000991)3.50257596
24Increased neuronal autofluorescent lipopigment (HP:0002074)3.45975135
25Hyperinsulinemic hypoglycemia (HP:0000825)3.42494175
26Eczematoid dermatitis (HP:0000976)3.30713677
27Deep venous thrombosis (HP:0002625)3.29741810
28Nuclear cataract (HP:0100018)3.24644295
29Orchitis (HP:0100796)3.23276819
30Recurrent abscess formation (HP:0002722)3.18096324
31Recurrent bacterial skin infections (HP:0005406)3.15601516
32Joint hemorrhage (HP:0005261)3.14403074
33Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.12877290
34Myositis (HP:0100614)3.09946202
35Hyperglycemia (HP:0003074)3.06271741
36Axonal loss (HP:0003447)3.05315294
37Symptomatic seizures (HP:0011145)3.04940470
38Retrobulbar optic neuritis (HP:0100654)3.04264295
39Optic neuritis (HP:0100653)3.04264295
40Myocardial infarction (HP:0001658)3.00927159
41Late onset (HP:0003584)2.93246960
42Ketoacidosis (HP:0001993)2.81781416
43Mediastinal lymphadenopathy (HP:0100721)2.79990117
44Abnormality of the vasculature of the conjunctiva (HP:0008054)2.74392818
45Prolonged partial thromboplastin time (HP:0003645)2.73905273
46Abnormality of monocarboxylic acid metabolism (HP:0010996)2.73353047
47Pathologic fracture (HP:0002756)2.69294649
48Increased serum ferritin (HP:0003281)2.58945928
49Purpura (HP:0000979)2.56108530
50Malnutrition (HP:0004395)2.54987491
51Abnormality of the common coagulation pathway (HP:0010990)2.49912308
52Hyperlipoproteinemia (HP:0010980)2.49442192
53Metaphyseal irregularity (HP:0003025)2.48235121
54Striae distensae (HP:0001065)2.46153053
55Ketosis (HP:0001946)2.42781088
56Diminished motivation (HP:0000745)2.42588297
57Autoimmune thrombocytopenia (HP:0001973)2.42479916
58Progressive neurologic deterioration (HP:0002344)2.41884636
59Apathy (HP:0000741)2.40567977
60Cerebral aneurysm (HP:0004944)2.39318192
61Intrahepatic cholestasis (HP:0001406)2.39051517
62Increased CSF protein (HP:0002922)2.39008477
63Conjugated hyperbilirubinemia (HP:0002908)2.36862991
64Cardiomegaly (HP:0001640)2.35850453
65Elevated erythrocyte sedimentation rate (HP:0003565)2.35088579
66Spontaneous hematomas (HP:0007420)2.34084301
67Mitral stenosis (HP:0001718)2.31436944
68Amyloidosis (HP:0011034)2.30801025
69Abnormality of calcium-phosphate metabolism (HP:0100530)2.30633645
70Increased IgE level (HP:0003212)2.27074258
71Asymmetric septal hypertrophy (HP:0001670)2.26426177
72Episodic fever (HP:0001954)2.26302344
73Inappropriate behavior (HP:0000719)2.25598218
74Thick nail (HP:0001805)2.24477487
75Skin nodule (HP:0200036)2.24419791
76Hematochezia (HP:0002573)2.20891613
77Arterial tortuosity (HP:0005116)2.20835036
78Abnormality of iron homeostasis (HP:0011031)2.19903205
79Polyneuropathy (HP:0001271)2.19661054
80Gingivitis (HP:0000230)2.17999122
81Epidermoid cyst (HP:0200040)2.16112556
82Obstructive lung disease (HP:0006536)2.15780139
83Chronic obstructive pulmonary disease (HP:0006510)2.15780139
84Loss of speech (HP:0002371)2.12729877
85Hypercholesterolemia (HP:0003124)2.11292548
86Hemoptysis (HP:0002105)2.09787729
87Petechiae (HP:0000967)2.09621258
88Abnormality of macrophages (HP:0004311)2.09264167
89J-shaped sella turcica (HP:0002680)2.08992819
90Peripheral demyelination (HP:0011096)2.07987054
91Disinhibition (HP:0000734)2.07575183
92Abnormality of the intrinsic pathway (HP:0010989)2.07384230
93Cerebral inclusion bodies (HP:0100314)2.05613225
94Tetany (HP:0001281)2.04572303
95Pulmonary infiltrates (HP:0002113)2.04294206
96Agitation (HP:0000713)2.02947104
97Hypoalphalipoproteinemia (HP:0003233)2.01959903
98Keratoconjunctivitis sicca (HP:0001097)2.00469471
99Dementia (HP:0000726)1.99315971
100Spondylolisthesis (HP:0003302)1.98620034
101Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.98088778
102Urticaria (HP:0001025)1.97132108
103Global brain atrophy (HP:0002283)1.96519851
104Mutism (HP:0002300)1.93981035
105Periodontitis (HP:0000704)1.93315117
106Prolonged neonatal jaundice (HP:0006579)1.93172495
107Abnormality of endocrine pancreas physiology (HP:0012093)1.91965714
108Abnormality of the pancreatic islet cells (HP:0006476)1.91965714
109Recurrent fungal infections (HP:0002841)1.90341812
110Vascular tortuosity (HP:0004948)1.87696589
111Vasculitis (HP:0002633)1.87380137
112Neurofibrillary tangles (HP:0002185)1.87157957
113Keratoconjunctivitis (HP:0001096)1.84911763
114Insulin-resistant diabetes mellitus (HP:0000831)1.84179284
115Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.83541882
116Tetraparesis (HP:0002273)1.82393665
117Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.82336159
118Hypophosphatemia (HP:0002148)1.82297244
119Agnosia (HP:0010524)1.81262596
120Upper motor neuron abnormality (HP:0002127)1.81126009
121Orthostatic hypotension (HP:0001278)1.80919748
122Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.80736491
123Recurrent skin infections (HP:0001581)1.80443121
124Abnormality of transition element cation homeostasis (HP:0011030)1.80425843
125Bone cyst (HP:0012062)1.79968364
126Bone pain (HP:0002653)1.78587282
127Ovoid vertebral bodies (HP:0003300)1.78391041
128Progressive visual loss (HP:0000529)1.77249258
129Thoracic kyphosis (HP:0002942)1.76931488
130Polygenic inheritance (HP:0010982)1.75750344
131Hepatosplenomegaly (HP:0001433)1.75557178
132Abnormality of glutamine family amino acid metabolism (HP:0010902)1.75278254
133Pancreatic islet-cell hyperplasia (HP:0004510)1.74069042
134Gingival bleeding (HP:0000225)1.73838542
135Acne (HP:0001061)1.73246086
136Hypolipoproteinemia (HP:0010981)1.73184078
137Supranuclear gaze palsy (HP:0000605)1.71532386
138Personality changes (HP:0000751)1.70397201
139Esophageal varix (HP:0002040)1.66297333
140Hypobetalipoproteinemia (HP:0003563)1.65006176
141Neuronal loss in central nervous system (HP:0002529)1.64808635
142Pulmonary embolism (HP:0002204)1.64563131
143Vertigo (HP:0002321)1.64496265
144Premature loss of primary teeth (HP:0006323)1.64262127
145Colitis (HP:0002583)1.64128496
146Basal ganglia calcification (HP:0002135)1.64033423
147Abnormality of the basal ganglia (HP:0002134)1.62824106
148Abdominal distention (HP:0003270)1.62113556
149Growth hormone excess (HP:0000845)1.61170468
150Large for gestational age (HP:0001520)1.60654998

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK157.09261799
2TGFBR24.26505983
3ERN13.60190589
4PIK3CG3.42248810
5INSRR2.92289322
6BLK2.79329110
7WNK32.74343399
8TAOK32.16907186
9TYK22.13062086
10GRK72.07504243
11PRPF4B2.06079262
12TAOK12.05154714
13FGR2.02697182
14EPHA31.95338762
15IRAK31.91548270
16EPHB11.90338685
17DDR21.83743119
18CAMK1D1.74781602
19IRAK41.63504881
20FGFR41.56665318
21CSF1R1.55594451
22TBK11.55413332
23NME21.54364499
24CSK1.47831342
25PTK61.44834104
26JAK11.44057177
27FRK1.42277422
28ACVR1B1.40440497
29TRIB31.35869496
30CAMK1G1.32444633
31TAOK21.31871533
32PDK21.31453157
33CDC42BPA1.28054921
34SIK11.26020132
35KDR1.25658017
36TNK21.23603547
37RIPK11.18907585
38MST1R1.17029565
39MAP3K141.14011135
40BMPR21.10465330
41PAK41.10328770
42RIPK41.10119231
43WNK41.09146589
44JAK21.05532971
45DYRK1B1.04492017
46MAP2K61.03337579
47ABL21.02544332
48KIT0.99081838
49IRAK10.99065918
50ZAP700.98929910
51STK240.96296093
52CAMKK20.95242853
53TESK10.92809890
54NEK90.90684900
55MAP4K10.89553760
56MAP3K10.89460839
57MAP3K20.89076831
58MAP3K30.84513223
59HIPK20.84485724
60MAP2K20.83802871
61TXK0.80840059
62HCK0.76532208
63ITK0.73425203
64PRKD20.69538095
65PKN20.66814123
66FGFR30.64412118
67BTK0.64163728
68PDK10.63064627
69PIM20.62536198
70GSK3A0.62267937
71FLT30.62209154
72TGFBR10.61731396
73LYN0.61227198
74TIE10.60744117
75IKBKB0.60460187
76IGF1R0.60448489
77MAP3K100.59972415
78ADRBK20.58681286
79CHUK0.58093128
80PTK20.57681731
81TRPM70.56856091
82SIK30.56194749
83DAPK20.55388211
84MAP2K30.54897957
85MAPK70.54600984
86EPHA20.54098131
87SCYL20.54073449
88MARK20.53056512
89IKBKE0.50604323
90MAP3K110.49912177
91FER0.49319561
92YES10.48174048
93BCKDK0.46997486
94EPHB20.46996818
95CAMK40.46938143
96CAMKK10.46284889
97CDK60.46033024
98JAK30.46029277
99MAP3K50.45332544
100MET0.45037465
101KSR20.44951239
102ARAF0.44735935
103LCK0.43376019
104MAPKAPK20.43212973
105MAPK120.42989806
106RPS6KL10.42431415
107RPS6KC10.42431415
108ABL10.42202297
109MATK0.41847536
110FES0.41748472
111EGFR0.41013532
112PRKCH0.40189778
113PDGFRB0.38510968
114SIK20.36773840
115MAPK40.36596876
116MOS0.35175765
117PRKAA20.35026424
118SYK0.34672844
119PRKD10.33792253
120RPS6KA60.33379717
121TSSK60.33164844
122MAP3K60.32887023
123TEC0.31542252
124PDPK10.30702964
125MAPK110.30689750
126STK100.30647616
127SGK20.30035017
128CDK30.29898388
129NLK0.29635681
130RPS6KA20.29380534
131MAP3K130.28724762
132IRAK20.27872334
133PAK20.27410166
134MARK30.26415580
135SGK30.26183034
136MAP2K40.25964801
137PDGFRA0.25721298
138FYN0.24810772

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.88928847
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.62141421
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.48699202
4Complement and coagulation cascades_Homo sapiens_hsa046103.19841840
5Other glycan degradation_Homo sapiens_hsa005113.13014989
6Lysosome_Homo sapiens_hsa041422.73003127
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.36081196
8Nitrogen metabolism_Homo sapiens_hsa009102.32098880
9Caffeine metabolism_Homo sapiens_hsa002322.06404754
10Prion diseases_Homo sapiens_hsa050202.02267995
11Type I diabetes mellitus_Homo sapiens_hsa049401.96994618
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.78280519
13Pertussis_Homo sapiens_hsa051331.72563823
14Collecting duct acid secretion_Homo sapiens_hsa049661.71327528
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.70325466
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.69625852
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69048904
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.67234859
19Asthma_Homo sapiens_hsa053101.65513942
20ABC transporters_Homo sapiens_hsa020101.63472887
21Arginine biosynthesis_Homo sapiens_hsa002201.63341351
22Graft-versus-host disease_Homo sapiens_hsa053321.61249549
23Allograft rejection_Homo sapiens_hsa053301.58548256
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47617678
25Osteoclast differentiation_Homo sapiens_hsa043801.43756621
26Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.37352073
27Autoimmune thyroid disease_Homo sapiens_hsa053201.35173260
28Leishmaniasis_Homo sapiens_hsa051401.33264482
29Tryptophan metabolism_Homo sapiens_hsa003801.32264253
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.29734895
31PPAR signaling pathway_Homo sapiens_hsa033201.17929916
32Histidine metabolism_Homo sapiens_hsa003401.17203986
33Fatty acid degradation_Homo sapiens_hsa000711.15210140
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13752041
35Legionellosis_Homo sapiens_hsa051341.11092226
36Phagosome_Homo sapiens_hsa041451.06360313
37Tuberculosis_Homo sapiens_hsa051521.04712831
38Starch and sucrose metabolism_Homo sapiens_hsa005001.02739064
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02052734
40Peroxisome_Homo sapiens_hsa041461.02002840
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.96355425
42Antigen processing and presentation_Homo sapiens_hsa046120.96310239
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90519044
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90373576
45Fat digestion and absorption_Homo sapiens_hsa049750.89142946
46Sulfur metabolism_Homo sapiens_hsa009200.87054800
47Malaria_Homo sapiens_hsa051440.86756683
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82501887
49Bile secretion_Homo sapiens_hsa049760.79950666
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79895538
51Type II diabetes mellitus_Homo sapiens_hsa049300.78644811
52Hepatitis C_Homo sapiens_hsa051600.76399804
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75765175
54Sphingolipid signaling pathway_Homo sapiens_hsa040710.74624023
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.74149233
56Folate biosynthesis_Homo sapiens_hsa007900.73921014
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72613400
58Toxoplasmosis_Homo sapiens_hsa051450.71953896
59Butanoate metabolism_Homo sapiens_hsa006500.71611189
60Renin-angiotensin system_Homo sapiens_hsa046140.70213116
61Shigellosis_Homo sapiens_hsa051310.70130142
62African trypanosomiasis_Homo sapiens_hsa051430.69166891
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68757070
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67186260
65Dorso-ventral axis formation_Homo sapiens_hsa043200.66531816
66Amoebiasis_Homo sapiens_hsa051460.65880940
67Herpes simplex infection_Homo sapiens_hsa051680.65746444
68beta-Alanine metabolism_Homo sapiens_hsa004100.65654987
69Lysine degradation_Homo sapiens_hsa003100.64360495
70Bladder cancer_Homo sapiens_hsa052190.64088585
71Phenylalanine metabolism_Homo sapiens_hsa003600.63195965
72Chemical carcinogenesis_Homo sapiens_hsa052040.63015258
73B cell receptor signaling pathway_Homo sapiens_hsa046620.62702904
74Viral myocarditis_Homo sapiens_hsa054160.62696589
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62047317
76Synaptic vesicle cycle_Homo sapiens_hsa047210.62047297
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.61725256
78Protein export_Homo sapiens_hsa030600.61364778
79T cell receptor signaling pathway_Homo sapiens_hsa046600.60388176
80Rheumatoid arthritis_Homo sapiens_hsa053230.59246107
81Fatty acid metabolism_Homo sapiens_hsa012120.59157611
82GnRH signaling pathway_Homo sapiens_hsa049120.58813870
83Insulin resistance_Homo sapiens_hsa049310.58647290
84Hepatitis B_Homo sapiens_hsa051610.58608857
85Retinol metabolism_Homo sapiens_hsa008300.55424623
86Selenocompound metabolism_Homo sapiens_hsa004500.55340999
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54287111
88Insulin secretion_Homo sapiens_hsa049110.54183843
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.54052543
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51237263
91Platelet activation_Homo sapiens_hsa046110.50301949
92Vibrio cholerae infection_Homo sapiens_hsa051100.49486993
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46685591
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46374233
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.46348472
96N-Glycan biosynthesis_Homo sapiens_hsa005100.46334225
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46142062
98Chemokine signaling pathway_Homo sapiens_hsa040620.45304349
99VEGF signaling pathway_Homo sapiens_hsa043700.45037556
100Arachidonic acid metabolism_Homo sapiens_hsa005900.44048112
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42660928
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42597049
103Sphingolipid metabolism_Homo sapiens_hsa006000.42286580
104Linoleic acid metabolism_Homo sapiens_hsa005910.42106519
105Endocytosis_Homo sapiens_hsa041440.41394250
106Vitamin digestion and absorption_Homo sapiens_hsa049770.40502483
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40281822
108Renin secretion_Homo sapiens_hsa049240.39867068
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39673949
110Salmonella infection_Homo sapiens_hsa051320.37957196
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36309857
112Renal cell carcinoma_Homo sapiens_hsa052110.35986414
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.35445528
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.34821038
115Measles_Homo sapiens_hsa051620.34419883
116Tyrosine metabolism_Homo sapiens_hsa003500.33880327
117Mineral absorption_Homo sapiens_hsa049780.33731886
118Apoptosis_Homo sapiens_hsa042100.33554768
119Ether lipid metabolism_Homo sapiens_hsa005650.33465806
120Hematopoietic cell lineage_Homo sapiens_hsa046400.33429163
121HIF-1 signaling pathway_Homo sapiens_hsa040660.32239676
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31644435
123Galactose metabolism_Homo sapiens_hsa000520.31640597
124Influenza A_Homo sapiens_hsa051640.30996729
125Regulation of autophagy_Homo sapiens_hsa041400.30873620
126mTOR signaling pathway_Homo sapiens_hsa041500.30166206
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29919892
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.29734008
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.28765270
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28756844
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28519787
132Pancreatic cancer_Homo sapiens_hsa052120.28051007
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27800029
134TNF signaling pathway_Homo sapiens_hsa046680.27746156
135Acute myeloid leukemia_Homo sapiens_hsa052210.27423125
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.26997118
137Estrogen signaling pathway_Homo sapiens_hsa049150.26425111
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26081882
139Ovarian steroidogenesis_Homo sapiens_hsa049130.25568833
140FoxO signaling pathway_Homo sapiens_hsa040680.24788160
141Prolactin signaling pathway_Homo sapiens_hsa049170.24746871
142Notch signaling pathway_Homo sapiens_hsa043300.24457490
143Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.22328960

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