MAFG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.16964159
2proline metabolic process (GO:0006560)7.31606623
3regulation of integrin activation (GO:0033623)6.81529357
4embryonic process involved in female pregnancy (GO:0060136)6.67060242
5transcription from mitochondrial promoter (GO:0006390)6.49832344
6positive regulation of protein homooligomerization (GO:0032464)6.40313978
7replication fork processing (GO:0031297)5.72302363
8regulation of protein homooligomerization (GO:0032462)5.72059052
9oxidative demethylation (GO:0070989)5.57297736
10negative regulation of erythrocyte differentiation (GO:0045647)5.36795710
11establishment of apical/basal cell polarity (GO:0035089)4.99429062
12embryonic placenta development (GO:0001892)4.91104070
13negative regulation of fatty acid biosynthetic process (GO:0045717)4.83972465
14cellular response to ATP (GO:0071318)4.82412831
15response to peptidoglycan (GO:0032494)4.77111714
16poly(A)+ mRNA export from nucleus (GO:0016973)4.70451099
17establishment of monopolar cell polarity (GO:0061162)4.61125997
18establishment or maintenance of monopolar cell polarity (GO:0061339)4.61125997
19glutamine family amino acid biosynthetic process (GO:0009084)4.55749276
20sulfur amino acid catabolic process (GO:0000098)4.50807544
21DNA strand renaturation (GO:0000733)4.43880880
22maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.30798073
23very-low-density lipoprotein particle assembly (GO:0034379)4.27067051
24mitochondrial DNA metabolic process (GO:0032042)4.21215410
25regulation of vitamin D biosynthetic process (GO:0060556)4.20913507
26negative regulation of protein oligomerization (GO:0032460)4.15611336
27negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.00444442
28lipopolysaccharide-mediated signaling pathway (GO:0031663)3.96151270
29protein localization to endosome (GO:0036010)3.91002450
30alkaloid metabolic process (GO:0009820)3.89266067
31negative regulation of Ras GTPase activity (GO:0034261)3.87110717
32cellular response to thyroid hormone stimulus (GO:0097067)3.84257781
33regulation of translational fidelity (GO:0006450)3.72415987
34mitotic G1 DNA damage checkpoint (GO:0031571)3.70125914
35regulation of cholesterol homeostasis (GO:2000188)3.66622188
36negative regulation of JAK-STAT cascade (GO:0046426)3.65619984
37somatic diversification of immune receptors via somatic mutation (GO:0002566)3.63897883
38somatic hypermutation of immunoglobulin genes (GO:0016446)3.63897883
39positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.62317073
40regulation of protein oligomerization (GO:0032459)3.62199399
41response to muramyl dipeptide (GO:0032495)3.61954587
42positive regulation of protein oligomerization (GO:0032461)3.61654976
43stress fiber assembly (GO:0043149)3.61466350
44cell migration in hindbrain (GO:0021535)3.54223975
45mitotic G1/S transition checkpoint (GO:0044819)3.51804854
46cellular response to arsenic-containing substance (GO:0071243)3.50395596
47negative regulation of cell cycle arrest (GO:0071157)3.48933589
48convergent extension (GO:0060026)3.47705747
49glycosphingolipid catabolic process (GO:0046479)3.47420481
50activation of MAPKKK activity (GO:0000185)3.47059255
51regulation of vitamin metabolic process (GO:0030656)3.39263874
52embryonic camera-type eye development (GO:0031076)3.39257341
53anatomical structure regression (GO:0060033)3.39053491
54regulation of protein polyubiquitination (GO:1902914)3.37452862
55mannose metabolic process (GO:0006013)3.36055740
56positive regulation of developmental pigmentation (GO:0048087)3.35886532
57G1 DNA damage checkpoint (GO:0044783)3.35480369
58mRNA cleavage (GO:0006379)3.34178005
59regulation of cAMP-dependent protein kinase activity (GO:2000479)3.32269543
60L-ascorbic acid metabolic process (GO:0019852)3.31381899
61response to thyroid hormone (GO:0097066)3.31167243
62apoptotic process involved in morphogenesis (GO:0060561)3.27705622
63negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.24583386
64modulation by symbiont of host cellular process (GO:0044068)3.22477242
65positive regulation of receptor recycling (GO:0001921)3.21683176
66heme transport (GO:0015886)3.21234264
67regulation of NFAT protein import into nucleus (GO:0051532)3.12350409
68NIK/NF-kappaB signaling (GO:0038061)3.10312855
69synaptic vesicle endocytosis (GO:0048488)3.09075959
70regulation of hippo signaling (GO:0035330)3.07470079
71germinal center formation (GO:0002467)3.07098237
72negative regulation of fatty acid metabolic process (GO:0045922)3.06605241
73regulation of cell size (GO:0008361)3.05036683
74intestinal cholesterol absorption (GO:0030299)3.04452029
75pinocytosis (GO:0006907)3.04164351
76positive regulation of chemokine biosynthetic process (GO:0045080)3.03905366
77glycolipid catabolic process (GO:0019377)3.03857560
78regulation of podosome assembly (GO:0071801)3.03318562
79glial cell migration (GO:0008347)3.01125842
80face development (GO:0060324)3.00702161
81L-phenylalanine metabolic process (GO:0006558)2.98634686
82erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.98634686
83negative regulation of heart rate (GO:0010459)2.96641762
84response to laminar fluid shear stress (GO:0034616)2.94834965
85regulation of membrane protein ectodomain proteolysis (GO:0051043)2.94026670
86oligosaccharide catabolic process (GO:0009313)2.91893245
87positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.91848973
88mitochondrion transport along microtubule (GO:0047497)2.90838565
89establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.90838565
90regulation of leukocyte degranulation (GO:0043300)2.89848687
91regulation of T-helper 2 cell differentiation (GO:0045628)2.87711064
92acylglycerol homeostasis (GO:0055090)2.85097292
93triglyceride homeostasis (GO:0070328)2.85097292
94histone H4-K12 acetylation (GO:0043983)2.84989345
95low-density lipoprotein particle clearance (GO:0034383)2.84664859
96spliceosomal tri-snRNP complex assembly (GO:0000244)2.84565834
97neuromuscular process controlling posture (GO:0050884)2.84437089
98activation of Rac GTPase activity (GO:0032863)2.83725616
99nodal signaling pathway (GO:0038092)2.83414511
100cellular response to zinc ion (GO:0071294)2.83172724
101plasma lipoprotein particle assembly (GO:0034377)2.82600768
102cholesterol efflux (GO:0033344)2.81941597
103positive regulation of cellular amide metabolic process (GO:0034250)2.81086105
104DNA deamination (GO:0045006)2.80523415
105regulation of mitochondrial depolarization (GO:0051900)2.78937772
106negative regulation of interleukin-12 production (GO:0032695)2.77863679
107regulation of response to reactive oxygen species (GO:1901031)2.75757973
108decidualization (GO:0046697)2.75461567
109L-alpha-amino acid transmembrane transport (GO:1902475)2.75364262
110positive regulation by host of viral transcription (GO:0043923)2.75242451
111hypotonic response (GO:0006971)2.75183543
112regulation of mast cell degranulation (GO:0043304)2.72526257
113membrane tubulation (GO:0097320)2.72156540
114macrophage activation involved in immune response (GO:0002281)2.69057739
115positive regulation of T cell apoptotic process (GO:0070234)2.67921538
116modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.67481021
117positive regulation by organism of defense response of other organism involved in symbiotic interact2.67481021
118modulation by symbiont of host immune response (GO:0052553)2.67481021
119positive regulation by symbiont of host defense response (GO:0052509)2.67481021
120modulation by symbiont of host defense response (GO:0052031)2.67481021
121modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.67481021
122regulation of chemokine biosynthetic process (GO:0045073)2.67169887
123regulation of early endosome to late endosome transport (GO:2000641)2.66145220
124labyrinthine layer development (GO:0060711)2.65464784
125regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.65422801
126trophectodermal cell differentiation (GO:0001829)2.64752158
127anterior/posterior axis specification, embryo (GO:0008595)2.64077836
128signal complex assembly (GO:0007172)2.62966301
129neutrophil activation involved in immune response (GO:0002283)2.62887969
130regulation of macrophage chemotaxis (GO:0010758)2.62852647
131regulation of posttranscriptional gene silencing (GO:0060147)2.62574180
132regulation of gene silencing by miRNA (GO:0060964)2.62574180
133regulation of gene silencing by RNA (GO:0060966)2.62574180
134glycogen catabolic process (GO:0005980)2.62270951
135cytoskeletal anchoring at plasma membrane (GO:0007016)2.62194110
136protein targeting to vacuole (GO:0006623)2.62185277
137protein targeting to lysosome (GO:0006622)2.62185277
138establishment of protein localization to vacuole (GO:0072666)2.62185277
1393-UTR-mediated mRNA stabilization (GO:0070935)2.61279290
140barbed-end actin filament capping (GO:0051016)2.61033114
141auditory receptor cell stereocilium organization (GO:0060088)2.60649847
142viral mRNA export from host cell nucleus (GO:0046784)2.60032444
143cellular protein complex localization (GO:0034629)2.59889021
144mRNA transcription (GO:0009299)2.59154685
145glucose 6-phosphate metabolic process (GO:0051156)2.59099807
146negative regulation of appetite (GO:0032099)2.58636906
147negative regulation of response to food (GO:0032096)2.58636906
148modulation by virus of host process (GO:0019054)2.57688724
149Golgi transport vesicle coating (GO:0048200)2.56888751
150COPI coating of Golgi vesicle (GO:0048205)2.56888751
151response to arsenic-containing substance (GO:0046685)2.55165491
152activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.51197845
153adherens junction assembly (GO:0034333)2.50601248
154positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.49981225
155pentose-phosphate shunt (GO:0006098)2.49208338
156regulation of nucleobase-containing compound transport (GO:0032239)2.49040668
157positive regulation of p38MAPK cascade (GO:1900745)2.45984644
158positive regulation of nuclease activity (GO:0032075)2.44551481
159ceramide catabolic process (GO:0046514)2.44382889
160positive regulation of protein dephosphorylation (GO:0035307)2.42474154
161regulation of myeloid leukocyte mediated immunity (GO:0002886)2.42361017
162positive regulation of leukocyte degranulation (GO:0043302)2.42142849
163T-helper 1 type immune response (GO:0042088)2.41315877
164mitotic chromosome condensation (GO:0007076)2.40470128
165regulation of type I interferon-mediated signaling pathway (GO:0060338)2.40253419
166adenosine receptor signaling pathway (GO:0001973)2.39343409
167hyaluronan catabolic process (GO:0030214)2.38980778
168focal adhesion assembly (GO:0048041)2.38379792
169cell-substrate adherens junction assembly (GO:0007045)2.38379792
170regulation of response to osmotic stress (GO:0047484)2.38153094
171regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.36551577
172skin morphogenesis (GO:0043589)2.36230712
173negative regulation of adherens junction organization (GO:1903392)2.35070910
174negative regulation of focal adhesion assembly (GO:0051895)2.35070910
175negative regulation of cell junction assembly (GO:1901889)2.35070910
176epithelial cell-cell adhesion (GO:0090136)2.34228007
177regulation of mast cell activation involved in immune response (GO:0033006)2.33864276
178endoplasmic reticulum unfolded protein response (GO:0030968)2.32518828
179mRNA transcription from RNA polymerase II promoter (GO:0042789)2.30348454
180cellular response to lipopolysaccharide (GO:0071222)2.29232610
181cortical actin cytoskeleton organization (GO:0030866)2.29062449
182toll-like receptor 3 signaling pathway (GO:0034138)2.28142127
183myeloid dendritic cell differentiation (GO:0043011)2.28103779
184TRIF-dependent toll-like receptor signaling pathway (GO:0035666)2.26969110
185ER-nucleus signaling pathway (GO:0006984)2.26325058
186negative regulation of toll-like receptor signaling pathway (GO:0034122)2.26207791
187regulation of cholesterol storage (GO:0010885)2.26091802
188regulation of regulated secretory pathway (GO:1903305)2.25314039
189positive regulation of Cdc42 GTPase activity (GO:0043089)2.24995127
190regulation of RNA export from nucleus (GO:0046831)2.24970401
191regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.23448187

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human3.68379171
2SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.31704427
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.31638594
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.31638594
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.31638594
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.18557964
7* RXR_22158963_ChIP-Seq_LIVER_Mouse2.79423487
8* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.67223856
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.54605179
10SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.49798094
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.48716410
12LXR_22292898_ChIP-Seq_THP-1_Human2.43055260
13* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.40711798
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.30665236
15* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.29026358
16NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.27867245
17VDR_21846776_ChIP-Seq_THP-1_Human2.27359950
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.24662313
19* ERG_21242973_ChIP-ChIP_JURKAT_Human2.22386131
20LXR_22158963_ChIP-Seq_LIVER_Mouse2.16724032
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.16703079
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.15763681
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12282275
24POU5F1_16518401_ChIP-PET_MESCs_Mouse2.08759510
25CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.02369405
26VDR_24763502_ChIP-Seq_THP-1_Human2.02050519
27NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.99772528
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.99335618
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.95587703
30* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.95114557
31TCF3_18692474_ChIP-Seq_MESCs_Mouse1.93988952
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90693118
33RACK7_27058665_Chip-Seq_MCF-7_Human1.90616661
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.87837843
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83538401
36KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.81970694
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.80545559
38* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.79220394
39* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78526480
40ZFP281_27345836_Chip-Seq_ESCs_Mouse1.76182243
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.75325973
42KDM2B_26808549_Chip-Seq_K562_Human1.73264330
43* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.73099022
44CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.71733315
45* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.68201705
46CLOCK_20551151_ChIP-Seq_293T_Human1.67926746
47TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.67211028
48RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.66212346
49NCOR1_26117541_ChIP-Seq_K562_Human1.64973227
50GATA1_19941826_ChIP-Seq_K562_Human1.63739498
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.62613587
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59953665
53TCF3_18692474_ChIP-Seq_MEFs_Mouse1.59595676
54NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.57599735
55E2F7_22180533_ChIP-Seq_HELA_Human1.56566351
56RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.55567584
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54998628
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54924718
59* KDM2B_26808549_Chip-Seq_DND41_Human1.54720530
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.54683725
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53512095
62* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52511407
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51938359
64ZNF263_19887448_ChIP-Seq_K562_Human1.51617188
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50647697
66MAF_26560356_Chip-Seq_TH1_Human1.50258282
67* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.49550460
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.48705839
69* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48025291
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.47667757
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.45922289
72PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44435750
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43988465
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.42158084
75* ATF3_27146783_Chip-Seq_COLON_Human1.37839231
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37599897
77PU.1_20513432_ChIP-Seq_Bcells_Mouse1.36298604
78FOXM1_23109430_ChIP-Seq_U2OS_Human1.35965359
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35062915
80* TET1_21451524_ChIP-Seq_MESCs_Mouse1.34744775
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33620903
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31494564
83MYC_22102868_ChIP-Seq_BL_Human1.31472174
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29073918
85* SPI1_23127762_ChIP-Seq_K562_Human1.28902085
86SCL_19346495_ChIP-Seq_HPC-7_Human1.28868017
87TFEB_21752829_ChIP-Seq_HELA_Human1.28724531
88RXRA_24833708_ChIP-Seq_LIVER_Mouse1.28154833
89CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27936320
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.26248416
91STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24885997
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24793709
93IRF8_27001747_Chip-Seq_BMDM_Mouse1.24548755
94PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.23832933
95CTCF_21964334_ChIP-Seq_BJAB-B_Human1.23698416
96TCF7_22412390_ChIP-Seq_EML_Mouse1.23544822
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22431652
98* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22039383
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21222454
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21085761
101GATA1_19941827_ChIP-Seq_MEL_Mouse1.20903324
102NANOG_18692474_ChIP-Seq_MESCs_Mouse1.20206371
103UTX_26944678_Chip-Seq_JUKART_Human1.19103818
104MAF_26560356_Chip-Seq_TH2_Human1.18772412
105WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17964629
106VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17447998
107BP1_19119308_ChIP-ChIP_Hs578T_Human1.17076342
108TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15944499
109* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15758470
110CREB1_26743006_Chip-Seq_LNCaP_Human1.15550843
111BCOR_27268052_Chip-Seq_Bcells_Human1.15519745
112NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.14504952
113UBF1/2_26484160_Chip-Seq_HMECs_Human1.14456654
114POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.14157567
115RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13806435
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12249561
117CDX2_20551321_ChIP-Seq_CACO-2_Human1.10826509
118NANOG_16518401_ChIP-PET_MESCs_Mouse1.09577928
119ELF1_20517297_ChIP-Seq_JURKAT_Human1.09026692
120SOX2_18692474_ChIP-Seq_MESCs_Mouse1.08545952
121SPI1_26923725_Chip-Seq_HPCs_Mouse1.08042736
122SMC4_20622854_ChIP-Seq_HELA_Human1.07385821
123RARA_24833708_ChIP-Seq_LIVER_Mouse1.06916949
124KDM2B_26808549_Chip-Seq_JURKAT_Human1.06787214
125CTCF_27219007_Chip-Seq_Bcells_Human1.06719610
126RARB_24833708_ChIP-Seq_LIVER_Mouse1.04982038
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04419667
128HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03242926
129SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03177454
130CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02027831
131TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01992196
132TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.01899846
133E2F1_20622854_ChIP-Seq_HELA_Human1.01628003
134CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01239309
135GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.01212605
136PHF8_20622854_ChIP-Seq_HELA_Human1.00789789
137TET1_21490601_ChIP-Seq_MESCs_Mouse1.00065557
138MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00022341
139* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99840765
140GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99489790
141UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98963367
142TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98885164
143GATA2_19941826_ChIP-Seq_K562_Human0.98747435
144ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98463838
145E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97876604
146P68_20966046_ChIP-Seq_HELA_Human0.96515161
147* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96154446
148TP53_22127205_ChIP-Seq_IMR90_Human0.96064122
149SA1_27219007_Chip-Seq_ERYTHROID_Human0.95803672
150ETS1_21867929_ChIP-Seq_TH2_Mouse0.95535312
151NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95417880
152TP53_20018659_ChIP-ChIP_R1E_Mouse0.95128797
153SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94836591
154RING1B_27294783_Chip-Seq_NPCs_Mouse0.94512995
155CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93463177
156CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93401632
157KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92561545
158SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90503180

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.82057448
2MP0009278_abnormal_bone_marrow4.68707791
3MP0005171_absent_coat_pigmentation3.62218749
4MP0005451_abnormal_body_composition3.57413436
5MP0005085_abnormal_gallbladder_physiolo3.43415758
6MP0005365_abnormal_bile_salt3.14853949
7MP0003172_abnormal_lysosome_physiology3.01838945
8MP0003436_decreased_susceptibility_to2.81390123
9MP0005058_abnormal_lysosome_morphology2.61334475
10MP0002139_abnormal_hepatobiliary_system2.56632366
11MP0010030_abnormal_orbit_morphology2.53214935
12MP0003453_abnormal_keratinocyte_physiol2.44678021
13MP0004233_abnormal_muscle_weight2.42243716
14MP0003890_abnormal_embryonic-extraembry2.31137002
15MP0003283_abnormal_digestive_organ2.27533092
16MP0003300_gastrointestinal_ulcer2.24168797
17MP0005360_urolithiasis2.19674935
18MP0002653_abnormal_ependyma_morphology2.06455919
19MP0004947_skin_inflammation2.04788893
20MP0008260_abnormal_autophagy2.02026010
21MP0010352_gastrointestinal_tract_polyps2.01210760
22MP0005076_abnormal_cell_differentiation1.99383275
23MP0004133_heterotaxia1.95117936
24MP0005397_hematopoietic_system_phenotyp1.94274499
25MP0001545_abnormal_hematopoietic_system1.94274499
26MP0005174_abnormal_tail_pigmentation1.93106393
27* MP0003656_abnormal_erythrocyte_physiolo1.88474797
28MP0003091_abnormal_cell_migration1.84731163
29MP0002009_preneoplasia1.82060989
30MP0000858_altered_metastatic_potential1.76397433
31MP0002419_abnormal_innate_immunity1.76009793
32MP0002269_muscular_atrophy1.71795624
33MP0002998_abnormal_bone_remodeling1.70740591
34MP0002148_abnormal_hypersensitivity_rea1.63985267
35MP0003705_abnormal_hypodermis_morpholog1.62412410
36MP0004808_abnormal_hematopoietic_stem1.60933163
37MP0009840_abnormal_foam_cell1.58667667
38MP0002332_abnormal_exercise_endurance1.57618359
39MP0003045_fibrosis1.53331817
40MP0000579_abnormal_nail_morphology1.51275125
41MP0004264_abnormal_extraembryonic_tissu1.51138098
42MP0003191_abnormal_cellular_cholesterol1.50104545
43MP0000639_abnormal_adrenal_gland1.49368585
44MP0005000_abnormal_immune_tolerance1.48679781
45MP0002249_abnormal_larynx_morphology1.47407453
46MP0001849_ear_inflammation1.47264764
47MP0001853_heart_inflammation1.44115114
48MP0000371_diluted_coat_color1.43238093
49MP0003119_abnormal_digestive_system1.41018355
50MP0009785_altered_susceptibility_to1.38967645
51MP0003075_altered_response_to1.36535669
52MP0001533_abnormal_skeleton_physiology1.33073257
53MP0008438_abnormal_cutaneous_collagen1.33072707
54MP0005025_abnormal_response_to1.32158821
55MP0005409_darkened_coat_color1.30522987
56MP0000604_amyloidosis1.30511771
57MP0005666_abnormal_adipose_tissue1.30377559
58MP0004858_abnormal_nervous_system1.29556420
59MP0002086_abnormal_extraembryonic_tissu1.28984325
60MP0000015_abnormal_ear_pigmentation1.28560541
61MP0003448_altered_tumor_morphology1.26817800
62MP0010234_abnormal_vibrissa_follicle1.26336634
63MP0006082_CNS_inflammation1.26174581
64MP0009333_abnormal_splenocyte_physiolog1.24888046
65MP0004019_abnormal_vitamin_homeostasis1.23295904
66MP0008875_abnormal_xenobiotic_pharmacok1.23072184
67MP0003566_abnormal_cell_adhesion1.21758814
68MP0005083_abnormal_biliary_tract1.21531023
69MP0004197_abnormal_fetal_growth/weight/1.20979943
70MP0003329_amyloid_beta_deposits1.20604284
71MP0008995_early_reproductive_senescence1.18970938
72MP0002282_abnormal_trachea_morphology1.16410595
73MP0000685_abnormal_immune_system1.14440630
74MP0003806_abnormal_nucleotide_metabolis1.14312802
75MP0005266_abnormal_metabolism1.14112905
76MP0010329_abnormal_lipoprotein_level1.14091758
77MP0000609_abnormal_liver_physiology1.13971905
78MP0005257_abnormal_intraocular_pressure1.13920265
79MP0002796_impaired_skin_barrier1.13250409
80MP0001835_abnormal_antigen_presentation1.11115932
81MP0000678_abnormal_parathyroid_gland1.08967758
82MP0005375_adipose_tissue_phenotype1.08917572
83MP0002452_abnormal_antigen_presenting1.08815113
84MP0008004_abnormal_stomach_pH1.08503973
85MP0009764_decreased_sensitivity_to1.07393690
86MP0009115_abnormal_fat_cell1.07370684
87MP0000747_muscle_weakness1.06510180
88MP0005387_immune_system_phenotype1.06403472
89MP0001790_abnormal_immune_system1.06403472
90MP0002733_abnormal_thermal_nociception1.02884170
91MP0000733_abnormal_muscle_development1.01021061
92MP0002723_abnormal_immune_serum0.99871712
93MP0002118_abnormal_lipid_homeostasis0.99523302
94MP0005621_abnormal_cell_physiology0.99422904
95MP0005332_abnormal_amino_acid0.98885876
96MP0004130_abnormal_muscle_cell0.98239469
97MP0001293_anophthalmia0.96089604
98MP0001340_abnormal_eyelid_morphology0.95984963
99MP0003303_peritoneal_inflammation0.95362103
100MP0000751_myopathy0.95239134
101MP0001915_intracranial_hemorrhage0.95130878
102MP0002084_abnormal_developmental_patter0.94194957
103MP0001348_abnormal_lacrimal_gland0.94030254
104MP0005319_abnormal_enzyme/_coenzyme0.93677294
105MP0008874_decreased_physiological_sensi0.92201923
106MP0005166_decreased_susceptibility_to0.92117228
107MP0001324_abnormal_eye_pigmentation0.91694643
108MP0005167_abnormal_blood-brain_barrier0.91308052
109MP0002254_reproductive_system_inflammat0.90136065
110MP0002735_abnormal_chemical_nociception0.89675719
111MP0001819_abnormal_immune_cell0.88203913
112MP0001845_abnormal_inflammatory_respons0.87944262
113MP0002420_abnormal_adaptive_immunity0.87819374
114MP0008469_abnormal_protein_level0.87166790
115MP0000470_abnormal_stomach_morphology0.87130559
116MP0010155_abnormal_intestine_physiology0.86702421
117MP0003828_pulmonary_edema0.85720471
118MP0001697_abnormal_embryo_size0.84920262
119MP0005075_abnormal_melanosome_morpholog0.84843153
120MP0002971_abnormal_brown_adipose0.84237562
121* MP0002398_abnormal_bone_marrow0.82945821
122MP0002111_abnormal_tail_morphology0.82538156
123MP0002060_abnormal_skin_morphology0.82326535
124MP0000598_abnormal_liver_morphology0.82023421
125MP0003252_abnormal_bile_duct0.81622098
126MP0004510_myositis0.81434212
127MP0003690_abnormal_glial_cell0.80786149
128MP0001672_abnormal_embryogenesis/_devel0.80414571
129MP0005380_embryogenesis_phenotype0.80414571
130MP0001730_embryonic_growth_arrest0.79899608
131MP0010630_abnormal_cardiac_muscle0.79497985
132MP0006072_abnormal_retinal_apoptosis0.79492578
133MP0002089_abnormal_postnatal_growth/wei0.79289849
134MP0005376_homeostasis/metabolism_phenot0.79056231
135MP0002085_abnormal_embryonic_tissue0.78236125
136MP0005464_abnormal_platelet_physiology0.78165109
137MP0001970_abnormal_pain_threshold0.77712253
138MP0003221_abnormal_cardiomyocyte_apopto0.76857821
139MP0000955_abnormal_spinal_cord0.76228557
140MP0000759_abnormal_skeletal_muscle0.75852858
141MP0005310_abnormal_salivary_gland0.74720613
142* MP0002429_abnormal_blood_cell0.74389034
143MP0002168_other_aberrant_phenotype0.73471815
144MP0002970_abnormal_white_adipose0.73393797
145MP0005390_skeleton_phenotype0.73137405
146MP0005165_increased_susceptibility_to0.73005797
147MP0003795_abnormal_bone_structure0.72798912
148MP0000716_abnormal_immune_system0.72689292
149MP0000350_abnormal_cell_proliferation0.71997545
150MP0003279_aneurysm0.71607478
151MP0003111_abnormal_nucleus_morphology0.71581567
152MP0005164_abnormal_response_to0.70764528
153MP0000920_abnormal_myelination0.69946462
154MP0003567_abnormal_fetal_cardiomyocyte0.69701098
155MP0005384_cellular_phenotype0.68625280
156MP0002697_abnormal_eye_size0.68514895
157MP0009931_abnormal_skin_appearance0.68469148
158MP0003755_abnormal_palate_morphology0.68464066
159MP0002877_abnormal_melanocyte_morpholog0.67888318
160MP0003633_abnormal_nervous_system0.67286688
161MP0003634_abnormal_glial_cell0.66786755
162MP0002405_respiratory_system_inflammati0.66561962
163MP0000762_abnormal_tongue_morphology0.65989817
164MP0003137_abnormal_impulse_conducting0.65306948
165MP0003935_abnormal_craniofacial_develop0.64899361
166MP0000343_altered_response_to0.64454695
167MP0005023_abnormal_wound_healing0.64029626
168MP0004185_abnormal_adipocyte_glucose0.64021834
169MP0010307_abnormal_tumor_latency0.63962080

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)5.86869982
2Turricephaly (HP:0000262)5.79449907
3Rib fusion (HP:0000902)4.97743217
4Pustule (HP:0200039)4.49422884
5Alopecia of scalp (HP:0002293)4.43464586
6Abnormality of liposaccharide metabolism (HP:0010968)4.19049484
7Abnormality of glycosphingolipid metabolism (HP:0004343)4.19049484
8Abnormality of glycolipid metabolism (HP:0010969)4.19049484
9Ulnar bowing (HP:0003031)4.17734818
10Annular pancreas (HP:0001734)4.08614100
11Rectovaginal fistula (HP:0000143)4.00304386
12Rectal fistula (HP:0100590)4.00304386
13Intestinal fistula (HP:0100819)3.97570409
14Vaginal fistula (HP:0004320)3.91345221
15Concave nail (HP:0001598)3.77106677
16Increased IgM level (HP:0003496)3.74947183
17Increased cerebral lipofuscin (HP:0011813)3.46633211
18Facial hemangioma (HP:0000329)3.45953772
19Coronal craniosynostosis (HP:0004440)3.35063719
20Mucopolysacchariduria (HP:0008155)3.29497677
21Urinary glycosaminoglycan excretion (HP:0003541)3.29497677
22Orthostatic hypotension (HP:0001278)3.26741998
23Tongue fasciculations (HP:0001308)3.12819328
24Abnormality of polysaccharide metabolism (HP:0011012)3.05193204
25Abnormality of glycosaminoglycan metabolism (HP:0004371)3.05193204
26Abnormality of mucopolysaccharide metabolism (HP:0011020)3.05193204
27Dysautonomia (HP:0002459)3.02263223
28Short humerus (HP:0005792)3.01720885
29Muscle fibrillation (HP:0010546)3.00693967
30Myocardial infarction (HP:0001658)3.00297942
31Neurofibrillary tangles (HP:0002185)2.99832971
32Nuclear cataract (HP:0100018)2.99499735
33Dysostosis multiplex (HP:0000943)2.94908908
34Distal lower limb amyotrophy (HP:0008944)2.91224422
35Cerebral inclusion bodies (HP:0100314)2.89463751
36Poikiloderma (HP:0001029)2.88003857
37Increased neuronal autofluorescent lipopigment (HP:0002074)2.86859178
38Abnormality of macrophages (HP:0004311)2.82758669
39Diaphragmatic weakness (HP:0009113)2.79229185
40Abnormality of the aortic arch (HP:0012303)2.77513343
41Vertebral compression fractures (HP:0002953)2.76549629
42Hyperacusis (HP:0010780)2.76073088
43Achilles tendon contracture (HP:0001771)2.75720842
44Aplasia/hypoplasia of the humerus (HP:0006507)2.74083597
45Abnormality of the lower motor neuron (HP:0002366)2.73803197
46Pancreatic islet-cell hyperplasia (HP:0004510)2.71162175
47Clumsiness (HP:0002312)2.70335495
48Male infertility (HP:0003251)2.65951843
49Loss of speech (HP:0002371)2.65275724
50Hypochromic anemia (HP:0001931)2.64219404
51Abnormal hemoglobin (HP:0011902)2.60658743
52Hypokinesia (HP:0002375)2.59910897
53Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.57372188
54Alacrima (HP:0000522)2.57025689
55Vacuolated lymphocytes (HP:0001922)2.56000814
56Congenital hip dislocation (HP:0001374)2.54766403
57Cerebral aneurysm (HP:0004944)2.54719733
58Increased connective tissue (HP:0009025)2.54433158
59Large for gestational age (HP:0001520)2.54333700
60Abnormality of the Achilles tendon (HP:0005109)2.52379569
61Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.50649468
62Vertebral hypoplasia (HP:0008417)2.50649468
63Lower limb hyperreflexia (HP:0002395)2.48109859
64Hamartoma (HP:0010566)2.46008893
65Polycythemia (HP:0001901)2.45621775
66Reticulocytosis (HP:0001923)2.40891421
67Asymmetric septal hypertrophy (HP:0001670)2.40555467
68Abnormality of aromatic amino acid family metabolism (HP:0004338)2.39141210
69Neuronal loss in central nervous system (HP:0002529)2.37445668
70Bowing of the arm (HP:0006488)2.37081127
71Bowed forearm bones (HP:0003956)2.37081127
72Short chin (HP:0000331)2.34278134
73Anteriorly placed anus (HP:0001545)2.34224257
74Growth hormone excess (HP:0000845)2.32043517
75Albinism (HP:0001022)2.30572238
76Distal lower limb muscle weakness (HP:0009053)2.30428270
77Upper limb amyotrophy (HP:0009129)2.28662546
78Distal upper limb amyotrophy (HP:0007149)2.28662546
79Deep venous thrombosis (HP:0002625)2.28481206
80Choanal stenosis (HP:0000452)2.26625172
81Intestinal atresia (HP:0011100)2.25873467
82Insomnia (HP:0100785)2.25176107
83Protrusio acetabuli (HP:0003179)2.24904262
84Abnormality of male internal genitalia (HP:0000022)2.24727956
85Diminished movement (HP:0002374)2.24538718
86Thin bony cortex (HP:0002753)2.23597231
87Broad face (HP:0000283)2.23131431
88Premature rupture of membranes (HP:0001788)2.23010428
89Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22062258
90Apathy (HP:0000741)2.21366742
91Hypobetalipoproteinemia (HP:0003563)2.20822172
92Centrally nucleated skeletal muscle fibers (HP:0003687)2.18872750
93Lower limb amyotrophy (HP:0007210)2.17652370
94Bilateral sensorineural hearing impairment (HP:0008619)2.14741676
95Supranuclear gaze palsy (HP:0000605)2.13939614
96Intrahepatic cholestasis (HP:0001406)2.12617376
97Hypertensive crisis (HP:0100735)2.12340105
98Increased serum ferritin (HP:0003281)2.12192853
99Xanthomatosis (HP:0000991)2.10249068
100Vertebral fusion (HP:0002948)2.09974307
101Obstructive sleep apnea (HP:0002870)2.09206945
102Diminished motivation (HP:0000745)2.09033612
103Broad alveolar ridges (HP:0000187)2.08699459
104Hypotrichosis (HP:0001006)2.05099834
105Coarse hair (HP:0002208)2.03686395
106Joint stiffness (HP:0001387)2.03149635
107Abnormality of monocarboxylic acid metabolism (HP:0010996)2.02351254
108Slow saccadic eye movements (HP:0000514)2.00702106
109Thoracic kyphosis (HP:0002942)1.97359112
110Hyperparathyroidism (HP:0000843)1.96569154
111Abnormality of the thoracic spine (HP:0100711)1.96263632
112Eczematoid dermatitis (HP:0000976)1.96076042
113Ankyloglossia (HP:0010296)1.95908105
114Disinhibition (HP:0000734)1.95688263
115Aplasia of the musculature (HP:0100854)1.95560444
116Segmental peripheral demyelination/remyelination (HP:0003481)1.94388556
117Fatigue (HP:0012378)1.93832988
118Abnormality of complement system (HP:0005339)1.93458981
119Increased CSF protein (HP:0002922)1.92129039
120Abnormality of the periventricular white matter (HP:0002518)1.91911787
121Difficulty climbing stairs (HP:0003551)1.91647921
122Premature skin wrinkling (HP:0100678)1.91502633
123Complement deficiency (HP:0004431)1.91488752
124Abnormality of the astrocytes (HP:0100707)1.91391780
125Astrocytoma (HP:0009592)1.91391780
126Generalized amyotrophy (HP:0003700)1.91206966
127Bifid uvula (HP:0000193)1.90283368
128Long palpebral fissure (HP:0000637)1.90178540
129Atonic seizures (HP:0010819)1.89348786
130Decreased lacrimation (HP:0000633)1.87905084
131Squamous cell carcinoma (HP:0002860)1.87615727
132Upper motor neuron abnormality (HP:0002127)1.86253869
133Recurrent bacterial skin infections (HP:0005406)1.85976642
134Tetraparesis (HP:0002273)1.85043353
135Status epilepticus (HP:0002133)1.84429807
136Fetal akinesia sequence (HP:0001989)1.83764797
137Interstitial pulmonary disease (HP:0006530)1.83659838
138Abnormal gallbladder physiology (HP:0012438)1.83442266
139Cholecystitis (HP:0001082)1.83442266
140Recurrent abscess formation (HP:0002722)1.83028133
141Axonal loss (HP:0003447)1.82674770
142Bone pain (HP:0002653)1.82627746
143Cheilitis (HP:0100825)1.81858948
144Peripheral hypomyelination (HP:0007182)1.81705163
145Popliteal pterygium (HP:0009756)1.81550167
146Amyloidosis (HP:0011034)1.81466144
147Abnormal large intestine physiology (HP:0012700)1.81223766
148Narrow nasal bridge (HP:0000446)1.79714871
149Generalized hyperpigmentation (HP:0007440)1.78987231
150Abnormality of endocrine pancreas physiology (HP:0012093)1.78551559
151Abnormality of the pancreatic islet cells (HP:0006476)1.78551559
152Purpura (HP:0000979)1.77710120
153Joint hemorrhage (HP:0005261)1.76912798
154Hypercortisolism (HP:0001578)1.76903579
155Split hand (HP:0001171)1.76811266
156Upper limb muscle weakness (HP:0003484)1.76475563
157Abnormal enzyme/coenzyme activity (HP:0012379)1.76081085
158Decreased motor nerve conduction velocity (HP:0003431)1.75669538
159Ketoacidosis (HP:0001993)1.75232132
160Petechiae (HP:0000967)1.75213092
161Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74711433
162Spondylolisthesis (HP:0003302)1.74588680
163Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.74453497
164Exercise-induced myalgia (HP:0003738)1.74432615
165Cellulitis (HP:0100658)1.72607144
166Hand muscle atrophy (HP:0009130)1.71773883
167Spinal rigidity (HP:0003306)1.71732489
168Disproportionate tall stature (HP:0001519)1.71654872
169Bowel incontinence (HP:0002607)1.71426226
170Systemic lupus erythematosus (HP:0002725)1.68749258
171Abnormality of skeletal muscle fiber size (HP:0012084)1.68588574
172Increased variability in muscle fiber diameter (HP:0003557)1.65619967
173Genu recurvatum (HP:0002816)1.63566425
174J-shaped sella turcica (HP:0002680)1.62220628
175Pathologic fracture (HP:0002756)1.59955352
176Dysmetric saccades (HP:0000641)1.59249477
177Abnormality of oral frenula (HP:0000190)1.58973873
178Mitral regurgitation (HP:0001653)1.58104042
179Impaired platelet aggregation (HP:0003540)1.58056630
180Abnormal platelet function (HP:0011869)1.58056630
181Cervical subluxation (HP:0003308)1.57412895
182Hemorrhage of the eye (HP:0011885)1.53801458
183Personality changes (HP:0000751)1.52388045
184Mutism (HP:0002300)1.52297029
185Truncus arteriosus (HP:0001660)1.50896299
186Polygenic inheritance (HP:0010982)1.49995616

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.03384947
2DDR24.44670106
3MAPK154.17132634
4MAP3K64.15793703
5MAP3K113.18173835
6FGR3.04006111
7TYRO32.97083862
8MATK2.87379490
9PINK12.86130039
10BMX2.47487893
11DAPK12.42677707
12NME22.38536979
13PDGFRA2.19358442
14PIM22.08358158
15UHMK12.06507116
16RIPK42.05254249
17YES12.03887991
18MAP3K141.99642021
19PRKD21.95789303
20CSK1.95039323
21EEF2K1.94666757
22AKT31.87221627
23MAP3K131.78672388
24SMG11.78508916
25PRPF4B1.76024981
26LATS21.57996737
27DYRK1B1.51015343
28MAP3K31.49780844
29TRPM71.47357990
30TBK11.46404496
31CDK121.44554004
32MAP3K11.35732775
33RPS6KC11.33836355
34RPS6KL11.33836355
35GSK3A1.30725386
36PHKG11.30624360
37PHKG21.30624360
38MOS1.25943381
39ARAF1.25179891
40IRAK21.24156450
41IRAK41.21575979
42CDK61.19668843
43RPS6KA61.17656410
44ERN11.15121622
45PIM11.13943543
46MAP3K91.11952836
47DAPK21.11723425
48TRIB31.06638734
49CDK71.06608530
50BRAF1.05155241
51CDC42BPA1.02856370
52PAK41.00303073
53SIK20.98313775
54ZAP700.92760904
55MAP3K80.91272129
56RIPK10.91046383
57HIPK20.89023379
58EPHA20.88327432
59MST1R0.86961714
60PDPK10.84123505
61ABL20.82675874
62MAPK110.82408137
63MTOR0.82323659
64TAOK20.81339473
65CAMK1D0.80144698
66ALK0.77874305
67EPHB10.76276476
68PRKAA10.72242177
69ERBB40.71896363
70RPS6KA10.69747890
71TYK20.69531119
72TESK10.68919293
73TAOK10.67098239
74CDK40.66369314
75BRD40.65539222
76CLK10.64771574
77CAMK1G0.64329467
78MAP3K100.63183941
79PDGFRB0.62932215
80BMPR20.61697625
81SIK10.61648985
82RAF10.60469232
83BLK0.59412696
84PTK20.58869154
85EGFR0.56203285
86MAP2K40.53935948
87NTRK10.53876113
88SGK10.53647592
89MAP3K20.53427244
90MAPK120.51982948
91PRKG20.48939822
92PAK20.48710683
93GRK50.48639107
94SIK30.48631709
95MAP4K10.48062486
96PAK60.47896672
97STK240.47554305
98MAPK100.47548691
99SGK30.47441752
100IRAK10.47347515
101PDK10.45712914
102STK30.44488223
103JAK30.43992818
104KSR10.43231003
105PTK60.41146880
106RPS6KB10.40564188
107PRKAA20.40187828
108JAK20.39354626
109MAPK40.38262395
110IKBKB0.36648099
111PRKCZ0.36634694
112MAPK10.36144497
113STK380.34693667
114NEK90.34044022
115DYRK20.33840278
116MAP3K50.33800054
117IKBKE0.33245963
118GRK70.33238459
119MAPK30.31977866
120ERBB30.31928741
121RPS6KA30.31851483
122TGFBR20.31102036
123TAOK30.30868186
124DMPK0.30645740
125CHUK0.29768575
126CAMK2G0.29609838
127MAP2K30.28256782
128MAPK140.27580979
129CHEK20.26980769
130IRAK30.26695633
131MARK20.26306244
132NTRK20.25162213
133PRKACG0.24964581
134MAPKAPK20.24660342
135CDK20.24367937
136RPS6KA20.23807399
137INSR0.22974030
138KSR20.22406297
139FGFR40.21517080
140CAMK40.21328576
141ABL10.21226742
142TNK20.20228286
143LYN0.19942915
144CAMK2A0.19096159
145MET0.18883382
146TTN0.18080776

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.10976896
2Other glycan degradation_Homo sapiens_hsa005113.19793240
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.98275537
4Arginine biosynthesis_Homo sapiens_hsa002202.96237893
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.47986176
6mTOR signaling pathway_Homo sapiens_hsa041502.27982342
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.21162800
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19990929
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.09158111
10Fatty acid metabolism_Homo sapiens_hsa012122.04833560
11Arginine and proline metabolism_Homo sapiens_hsa003302.02339612
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.96296506
13Osteoclast differentiation_Homo sapiens_hsa043801.95582070
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.90811211
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.86563432
16Staphylococcus aureus infection_Homo sapiens_hsa051501.82793837
17Lysine degradation_Homo sapiens_hsa003101.76851323
18TNF signaling pathway_Homo sapiens_hsa046681.74534366
19Sulfur relay system_Homo sapiens_hsa041221.69727048
20Complement and coagulation cascades_Homo sapiens_hsa046101.63025221
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63011555
22Biosynthesis of amino acids_Homo sapiens_hsa012301.61302291
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.58611087
24Base excision repair_Homo sapiens_hsa034101.56136302
25Leishmaniasis_Homo sapiens_hsa051401.56045570
26B cell receptor signaling pathway_Homo sapiens_hsa046621.54826339
27Bladder cancer_Homo sapiens_hsa052191.54154826
28Malaria_Homo sapiens_hsa051441.53412287
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.53394259
30Longevity regulating pathway - mammal_Homo sapiens_hsa042111.53076671
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.51687209
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40335898
33Renal cell carcinoma_Homo sapiens_hsa052111.40260927
34Circadian rhythm_Homo sapiens_hsa047101.39440231
35Nitrogen metabolism_Homo sapiens_hsa009101.38739559
36Salmonella infection_Homo sapiens_hsa051321.38129528
37Influenza A_Homo sapiens_hsa051641.37336952
38Notch signaling pathway_Homo sapiens_hsa043301.37210049
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.32676147
40Tuberculosis_Homo sapiens_hsa051521.32271996
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31789215
42Fructose and mannose metabolism_Homo sapiens_hsa000511.31155164
43Non-small cell lung cancer_Homo sapiens_hsa052231.30758910
44Hepatitis B_Homo sapiens_hsa051611.27621681
45Toxoplasmosis_Homo sapiens_hsa051451.26775301
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25647293
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22985318
48Tryptophan metabolism_Homo sapiens_hsa003801.22128015
49Pertussis_Homo sapiens_hsa051331.18008593
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15935049
51Amoebiasis_Homo sapiens_hsa051461.15920095
52Hippo signaling pathway_Homo sapiens_hsa043901.14553974
53Hedgehog signaling pathway_Homo sapiens_hsa043401.13276778
54Apoptosis_Homo sapiens_hsa042101.10537672
55Hepatitis C_Homo sapiens_hsa051601.09042111
56Steroid biosynthesis_Homo sapiens_hsa001001.08641403
57Dorso-ventral axis formation_Homo sapiens_hsa043201.07455965
58Rheumatoid arthritis_Homo sapiens_hsa053231.06361803
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04946973
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03657632
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03210176
62Maturity onset diabetes of the young_Homo sapiens_hsa049501.02629250
63Adherens junction_Homo sapiens_hsa045201.02614989
64Glioma_Homo sapiens_hsa052141.00846137
65Starch and sucrose metabolism_Homo sapiens_hsa005001.00270572
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00265026
67ABC transporters_Homo sapiens_hsa020100.99557119
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.96635348
69ErbB signaling pathway_Homo sapiens_hsa040120.94864370
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.93751392
71African trypanosomiasis_Homo sapiens_hsa051430.93102941
72Pentose phosphate pathway_Homo sapiens_hsa000300.92666174
73Small cell lung cancer_Homo sapiens_hsa052220.92064088
74HIF-1 signaling pathway_Homo sapiens_hsa040660.90881874
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90625110
76Insulin signaling pathway_Homo sapiens_hsa049100.90110822
77VEGF signaling pathway_Homo sapiens_hsa043700.89929442
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88818691
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.88534275
80Acute myeloid leukemia_Homo sapiens_hsa052210.88225180
81Galactose metabolism_Homo sapiens_hsa000520.83550601
82Herpes simplex infection_Homo sapiens_hsa051680.83448628
83Measles_Homo sapiens_hsa051620.83019637
84Prostate cancer_Homo sapiens_hsa052150.83018800
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81916015
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.81606569
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81389197
88Chemokine signaling pathway_Homo sapiens_hsa040620.80478350
89Mismatch repair_Homo sapiens_hsa034300.79915151
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79178950
91Chronic myeloid leukemia_Homo sapiens_hsa052200.78986513
92Lysosome_Homo sapiens_hsa041420.77070082
93Folate biosynthesis_Homo sapiens_hsa007900.76072075
94PPAR signaling pathway_Homo sapiens_hsa033200.73962124
95Thyroid cancer_Homo sapiens_hsa052160.73829000
96Shigellosis_Homo sapiens_hsa051310.73807344
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73182433
98Choline metabolism in cancer_Homo sapiens_hsa052310.73111365
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73022105
100Bile secretion_Homo sapiens_hsa049760.71975690
101Endocytosis_Homo sapiens_hsa041440.71763336
102AMPK signaling pathway_Homo sapiens_hsa041520.71718564
103T cell receptor signaling pathway_Homo sapiens_hsa046600.71582582
104Focal adhesion_Homo sapiens_hsa045100.71552210
105Estrogen signaling pathway_Homo sapiens_hsa049150.70197754
106TGF-beta signaling pathway_Homo sapiens_hsa043500.70185842
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70130742
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.69113101
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69103199
110Viral carcinogenesis_Homo sapiens_hsa052030.68667588
111Prion diseases_Homo sapiens_hsa050200.67950487
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67874745
113HTLV-I infection_Homo sapiens_hsa051660.66357039
114Histidine metabolism_Homo sapiens_hsa003400.66224588
115Vibrio cholerae infection_Homo sapiens_hsa051100.65835246
116Phenylalanine metabolism_Homo sapiens_hsa003600.65511126
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.65354368
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.62750924
119beta-Alanine metabolism_Homo sapiens_hsa004100.62527904
120Epstein-Barr virus infection_Homo sapiens_hsa051690.62516365
121Synaptic vesicle cycle_Homo sapiens_hsa047210.60393967
122Legionellosis_Homo sapiens_hsa051340.59889977
123mRNA surveillance pathway_Homo sapiens_hsa030150.59735791
124FoxO signaling pathway_Homo sapiens_hsa040680.58666687
125Butanoate metabolism_Homo sapiens_hsa006500.57737129
126Selenocompound metabolism_Homo sapiens_hsa004500.57609856
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.56097845
128Sphingolipid metabolism_Homo sapiens_hsa006000.55826122
129Long-term potentiation_Homo sapiens_hsa047200.54295952
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53500981
131Wnt signaling pathway_Homo sapiens_hsa043100.53489731
132Peroxisome_Homo sapiens_hsa041460.52605832
133Insulin resistance_Homo sapiens_hsa049310.52295304
134Platelet activation_Homo sapiens_hsa046110.51599332
135Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51082578
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50896117
137Cyanoamino acid metabolism_Homo sapiens_hsa004600.50855587
138Phagosome_Homo sapiens_hsa041450.49923582
139MAPK signaling pathway_Homo sapiens_hsa040100.48093076
140Inositol phosphate metabolism_Homo sapiens_hsa005620.47694003
141Type II diabetes mellitus_Homo sapiens_hsa049300.45600363
142Viral myocarditis_Homo sapiens_hsa054160.44667177
143Fatty acid degradation_Homo sapiens_hsa000710.43238478
144Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41989050
145Endometrial cancer_Homo sapiens_hsa052130.41434957
146MicroRNAs in cancer_Homo sapiens_hsa052060.40733586
147Glycerolipid metabolism_Homo sapiens_hsa005610.39480151
148Fatty acid elongation_Homo sapiens_hsa000620.38804180
149Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38636959
150Proteoglycans in cancer_Homo sapiens_hsa052050.38280684
151Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38121822
152Collecting duct acid secretion_Homo sapiens_hsa049660.37916847
153GnRH signaling pathway_Homo sapiens_hsa049120.36204351
154Caffeine metabolism_Homo sapiens_hsa002320.35983006
155Basal cell carcinoma_Homo sapiens_hsa052170.34612327
156Prolactin signaling pathway_Homo sapiens_hsa049170.34426132
157Gap junction_Homo sapiens_hsa045400.33666442
158Chemical carcinogenesis_Homo sapiens_hsa052040.32937890
159Colorectal cancer_Homo sapiens_hsa052100.32256841
160One carbon pool by folate_Homo sapiens_hsa006700.32022474
161Pancreatic cancer_Homo sapiens_hsa052120.31333855
162Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29712344

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »