MAG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.47433757
2synaptic vesicle maturation (GO:0016188)7.40506675
3synaptic vesicle docking involved in exocytosis (GO:0016081)7.28910229
4axon ensheathment (GO:0008366)7.25538345
5ensheathment of neurons (GO:0007272)7.25538345
6myelination (GO:0042552)7.21225195
7glutamate secretion (GO:0014047)6.90858511
8synaptic vesicle exocytosis (GO:0016079)6.28114565
9cellular potassium ion homeostasis (GO:0030007)6.00400278
10long-chain fatty acid biosynthetic process (GO:0042759)5.88568920
11regulation of synaptic vesicle exocytosis (GO:2000300)5.87178368
12regulation of short-term neuronal synaptic plasticity (GO:0048172)5.75857416
13sodium ion export (GO:0071436)5.58605977
14membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.36739409
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.32869082
16negative regulation of neurotransmitter secretion (GO:0046929)5.18361136
17myelin maintenance (GO:0043217)5.08410395
18neurotransmitter secretion (GO:0007269)5.02524326
19regulation of synaptic vesicle transport (GO:1902803)5.00959965
20oligodendrocyte differentiation (GO:0048709)4.94333897
21regulation of neuronal synaptic plasticity (GO:0048168)4.91461017
22locomotory exploration behavior (GO:0035641)4.69752515
23potassium ion homeostasis (GO:0055075)4.58364754
24negative regulation of neurotransmitter transport (GO:0051589)4.57421075
25peptidyl-tyrosine autophosphorylation (GO:0038083)4.54918689
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.47556955
27potassium ion import (GO:0010107)4.46392204
28cholesterol biosynthetic process (GO:0006695)4.41225457
29negative regulation of synaptic transmission, GABAergic (GO:0032229)4.38267842
30glycerophospholipid catabolic process (GO:0046475)4.36122989
31creatine metabolic process (GO:0006600)4.29017152
32positive regulation of synapse maturation (GO:0090129)4.27859388
33postsynaptic membrane organization (GO:0001941)4.26579130
34L-amino acid import (GO:0043092)4.24760998
35regulation of collateral sprouting (GO:0048670)4.24576655
36vocalization behavior (GO:0071625)4.23694056
37regulation of long-term neuronal synaptic plasticity (GO:0048169)4.22200027
38ionotropic glutamate receptor signaling pathway (GO:0035235)4.20676593
39neurotransmitter transport (GO:0006836)4.15309262
40presynaptic membrane organization (GO:0097090)4.14004762
41astrocyte development (GO:0014002)4.13353245
42cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.09734783
43negative regulation of protein localization to cell surface (GO:2000009)4.06291516
44establishment of mitochondrion localization (GO:0051654)4.05349330
45photoreceptor cell differentiation (GO:0046530)4.03318917
46eye photoreceptor cell differentiation (GO:0001754)4.03318917
47presynaptic membrane assembly (GO:0097105)3.93562418
48regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.92853140
49peripheral nervous system axon ensheathment (GO:0032292)3.91888517
50myelination in peripheral nervous system (GO:0022011)3.91888517
51regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.90475065
52regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.89714997
53exploration behavior (GO:0035640)3.85750166
54negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.85088434
55sterol biosynthetic process (GO:0016126)3.84231001
56asymmetric protein localization (GO:0008105)3.81052429
57apical protein localization (GO:0045176)3.80329990
58regulation of synaptic plasticity (GO:0048167)3.80020490
59adhesion of symbiont to host cell (GO:0044650)3.76774481
60virion attachment to host cell (GO:0019062)3.76774481
61response to methylmercury (GO:0051597)3.76228609
62regulation of neurotransmitter levels (GO:0001505)3.75981227
63long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.75724957
64neuromuscular process controlling balance (GO:0050885)3.73359017
65acidic amino acid transport (GO:0015800)3.71245641
66amyloid precursor protein metabolic process (GO:0042982)3.68430483
67regulation of glutamate receptor signaling pathway (GO:1900449)3.68085746
68transmission of nerve impulse (GO:0019226)3.66462624
69* substantia nigra development (GO:0021762)3.66013646
70response to redox state (GO:0051775)3.65880139
71regulation of neurotransmitter secretion (GO:0046928)3.62073510
72positive regulation of membrane potential (GO:0045838)3.61925841
73synaptic transmission, glutamatergic (GO:0035249)3.61730012
74adult walking behavior (GO:0007628)3.57810229
75import into cell (GO:0098657)3.57146535
76positive regulation of dendritic spine development (GO:0060999)3.57100436
77cellular sodium ion homeostasis (GO:0006883)3.54689476
78regulation of excitatory postsynaptic membrane potential (GO:0060079)3.53893468
79neurotransmitter-gated ion channel clustering (GO:0072578)3.53104735
80regulation of ARF protein signal transduction (GO:0032012)3.50723620
81long-term synaptic potentiation (GO:0060291)3.50352215
82cerebellar Purkinje cell differentiation (GO:0021702)3.49421239
83cell communication by electrical coupling (GO:0010644)3.48605261
84positive regulation of oligodendrocyte differentiation (GO:0048714)3.47119286
85long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.44845629
86regulation of voltage-gated calcium channel activity (GO:1901385)3.44718718
87neuronal ion channel clustering (GO:0045161)3.40750491
88regulation of neurotransmitter transport (GO:0051588)3.40202248
89isoprenoid biosynthetic process (GO:0008299)3.39202825
90glutamate receptor signaling pathway (GO:0007215)3.33727772
91regulation of synapse maturation (GO:0090128)3.33557484
92synaptic vesicle endocytosis (GO:0048488)3.33476536
93gamma-aminobutyric acid signaling pathway (GO:0007214)3.32485985
94membrane tubulation (GO:0097320)3.31322433
95L-glutamate transport (GO:0015813)3.30666199
96neuronal action potential propagation (GO:0019227)3.30567278
97protein localization to synapse (GO:0035418)3.29960290
98regulation of synapse structural plasticity (GO:0051823)3.29785199
99gamma-aminobutyric acid transport (GO:0015812)3.28712280
100negative regulation of inclusion body assembly (GO:0090084)3.27077729
101long-term memory (GO:0007616)3.26734886
102positive regulation of action potential (GO:0045760)3.26679194
103neuron-neuron synaptic transmission (GO:0007270)3.25919503
104response to lipoprotein particle (GO:0055094)3.24318131
105regulation of dendritic spine morphogenesis (GO:0061001)3.23473968
106fatty-acyl-CoA biosynthetic process (GO:0046949)3.23031403
107regulation of postsynaptic membrane potential (GO:0060078)3.21641234
108cellular response to epinephrine stimulus (GO:0071872)3.20305161
109protein palmitoylation (GO:0018345)3.18770229
110magnesium ion transport (GO:0015693)3.16940432
111regulation of dendritic spine development (GO:0060998)3.16895980
112amino acid import (GO:0043090)3.13793247
113neuron cell-cell adhesion (GO:0007158)3.12587029
114regulation of vesicle fusion (GO:0031338)3.12151472
115regulation of synaptic transmission (GO:0050804)3.11424225
116negative regulation of dendrite morphogenesis (GO:0050774)3.10686089
117cytoskeletal anchoring at plasma membrane (GO:0007016)3.10354349
118cerebral cortex radially oriented cell migration (GO:0021799)3.09540009
119peripheral nervous system development (GO:0007422)3.07214802
120negative regulation of JUN kinase activity (GO:0043508)3.06340801
121positive regulation of neurotransmitter secretion (GO:0001956)3.03971266
122positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.03857570
123regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.02624577
124positive regulation of neurotransmitter transport (GO:0051590)3.02499186
125glycosylceramide metabolic process (GO:0006677)3.02268836
126positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.01018773
127negative regulation of axon extension (GO:0030517)3.00544301
128cerebellar Purkinje cell layer development (GO:0021680)2.98424026
129fatty-acyl-CoA metabolic process (GO:0035337)2.98164057
130astrocyte differentiation (GO:0048708)2.97785690
131neuromuscular process controlling posture (GO:0050884)2.96484160
132auditory behavior (GO:0031223)2.95748751
133* negative regulation of axonogenesis (GO:0050771)2.95559715
134detection of calcium ion (GO:0005513)2.91715573
135layer formation in cerebral cortex (GO:0021819)2.89869454
136regulation of synaptic transmission, glutamatergic (GO:0051966)2.89809833
137limb bud formation (GO:0060174)2.88280703
138cerebellar granule cell differentiation (GO:0021707)2.88081514
139neuron remodeling (GO:0016322)2.86632004
140response to epinephrine (GO:0071871)2.84674871
141glycine transport (GO:0015816)2.81129624
142axon development (GO:0061564)2.80337288
143glial cell development (GO:0021782)2.78399481
144very long-chain fatty acid metabolic process (GO:0000038)2.78344248
145GPI anchor biosynthetic process (GO:0006506)2.72818345
146adhesion of symbiont to host (GO:0044406)2.72403879
147cellular response to monoamine stimulus (GO:0071868)2.71618063
148cellular response to catecholamine stimulus (GO:0071870)2.71618063
149peptidyl-cysteine modification (GO:0018198)2.71151758
150neurotransmitter catabolic process (GO:0042135)2.69874579
151GPI anchor metabolic process (GO:0006505)2.68093282
152negative regulation of execution phase of apoptosis (GO:1900118)2.63793190
153leukocyte migration involved in inflammatory response (GO:0002523)2.63018927
154nerve growth factor signaling pathway (GO:0038180)2.62400410
155cyclic nucleotide catabolic process (GO:0009214)2.60703052
156amyloid precursor protein catabolic process (GO:0042987)2.59466208
157nucleotide transmembrane transport (GO:1901679)2.56746954
158membrane assembly (GO:0071709)2.56195260
159glial cell differentiation (GO:0010001)2.56167382
160dendritic spine morphogenesis (GO:0060997)2.56121808
161thioester biosynthetic process (GO:0035384)2.55344189
162acyl-CoA biosynthetic process (GO:0071616)2.55344189
163response to hepatocyte growth factor (GO:0035728)2.55127074
164cellular response to hepatocyte growth factor stimulus (GO:0035729)2.55127074
165enteric nervous system development (GO:0048484)2.54957746
166positive regulation of glial cell differentiation (GO:0045687)2.52527564
167response to monoamine (GO:0071867)2.50277043
168response to catecholamine (GO:0071869)2.50277043
169preassembly of GPI anchor in ER membrane (GO:0016254)2.49710140
170organ growth (GO:0035265)2.49619552
171interleukin-6-mediated signaling pathway (GO:0070102)2.49130750
172neurotransmitter uptake (GO:0001504)2.47862353
173positive regulation of gliogenesis (GO:0014015)2.47146471
174regulation of dopamine metabolic process (GO:0042053)2.45430427
175regulation of catecholamine metabolic process (GO:0042069)2.45430427
176axon ensheathment in central nervous system (GO:0032291)11.2613532
177central nervous system myelination (GO:0022010)11.2613532

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.27940042
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.02936074
3SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.61256237
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52517812
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.51082663
6EZH2_22144423_ChIP-Seq_EOC_Human2.50102848
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.44760647
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.42792793
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.20434688
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.20183471
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.20183471
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19140480
13TAF15_26573619_Chip-Seq_HEK293_Human2.16421197
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10337233
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.08676854
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.05989018
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.04791019
18* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.04507560
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.03538184
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01001094
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.97451989
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.97411733
23OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.95227202
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.95174207
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.90025279
26AR_21572438_ChIP-Seq_LNCaP_Human1.89909478
27RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.85671662
28KDM2B_26808549_Chip-Seq_K562_Human1.83874803
29* DROSHA_22980978_ChIP-Seq_HELA_Human1.82033397
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.81188868
31RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.80677057
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.74282941
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.74078421
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73691219
35* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.68130655
36ER_23166858_ChIP-Seq_MCF-7_Human1.67433153
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.67415681
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64377840
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60236529
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59661412
41* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55041943
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.53463460
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52125552
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48058105
45VDR_22108803_ChIP-Seq_LS180_Human1.47779708
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.47454327
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47276080
48REST_21632747_ChIP-Seq_MESCs_Mouse1.46183973
49* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45462744
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.44147472
51* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36857367
52STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.35631742
53TET1_21490601_ChIP-Seq_MESCs_Mouse1.34148075
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33384587
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33096137
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33068361
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32947620
58OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.30816790
59WT1_19549856_ChIP-ChIP_CCG9911_Human1.30718971
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30664620
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30307240
62* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29858661
63LXR_22292898_ChIP-Seq_THP-1_Human1.26775440
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26206730
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25737350
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.24425224
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.23457463
68CTCF_27219007_Chip-Seq_Bcells_Human1.22292255
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22039293
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19549007
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19518136
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17486975
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16872378
74P300_19829295_ChIP-Seq_ESCs_Human1.15374530
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15032159
76STAT3_23295773_ChIP-Seq_U87_Human1.14515697
77SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.14430680
78SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13922634
79OCT4_19829295_ChIP-Seq_ESCs_Human1.11758300
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11529956
81WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09461086
82AR_19668381_ChIP-Seq_PC3_Human1.09114859
83LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08133135
84CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07328468
85GATA1_26923725_Chip-Seq_HPCs_Mouse1.07290069
86EOMES_21245162_ChIP-Seq_HESCs_Human1.06230253
87FUS_26573619_Chip-Seq_HEK293_Human1.06089933
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04717496
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04717496
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02818208
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02316843
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02310743
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.00459016
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00227012
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.00039567
96EP300_21415370_ChIP-Seq_HL-1_Mouse0.99854740
97TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98148897
98RNF2_27304074_Chip-Seq_NSC_Mouse0.98115482
99* TCF4_23295773_ChIP-Seq_U87_Human0.98005695
100SMAD4_21799915_ChIP-Seq_A2780_Human0.97518907
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97107251
102NANOG_18555785_Chip-Seq_ESCs_Mouse0.96563744
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96437147
104DPY_21335234_ChIP-Seq_ESCs_Mouse0.95690028
105NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95514268
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95104695
107SMC4_20622854_ChIP-Seq_HELA_Human0.94731205
108RING1B_27294783_Chip-Seq_ESCs_Mouse0.94706122
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94562786
110RING1B_27294783_Chip-Seq_NPCs_Mouse0.94173593
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93725549
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91814154
113P300_18555785_Chip-Seq_ESCs_Mouse0.91809597
114MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91603786
115CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91261256
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91146579
117YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91020323
118SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90565188
119EGR1_19032775_ChIP-ChIP_M12_Human0.90015480
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89514692
121PRDM14_20953172_ChIP-Seq_ESCs_Human0.89467468
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89157623
123TBL1_22424771_ChIP-Seq_293T_Human0.87815968
124MYC_19915707_ChIP-ChIP_AK7_Human0.87612504
125SOX2_21211035_ChIP-Seq_LN229_Gbm0.86898574
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85970183
127ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85900226
128NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85540413
129ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85157992
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84952385
131* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84828385
132SMAD4_21741376_ChIP-Seq_EPCs_Human0.84742089
133EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84456739
134NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84181122
135* KDM2B_26808549_Chip-Seq_DND41_Human0.83617151
136SMAD4_21741376_ChIP-Seq_ESCs_Human0.83612321
137ERG_21242973_ChIP-ChIP_JURKAT_Human0.83167185
138DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.80161173
139SMAD3_21741376_ChIP-Seq_ESCs_Human0.79524590
140TP53_23651856_ChIP-Seq_MEFs_Mouse0.78853222
141SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.78601378
142RUNX1_26923725_Chip-Seq_HPCs_Mouse0.78238160
143MITF_21258399_ChIP-Seq_MELANOMA_Human0.77894638
144KDM2B_26808549_Chip-Seq_JURKAT_Human0.77574250
145KLF4_19829295_ChIP-Seq_ESCs_Human0.76607131
146CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.76114819
147ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.75942761
148SMAD4_21741376_ChIP-Seq_HESCs_Human0.74976029
149SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.72683206

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0000920_abnormal_myelination5.23836099
2MP0003880_abnormal_central_pattern4.42431157
3MP0004270_analgesia3.61489477
4MP0003690_abnormal_glial_cell3.32955639
5MP0003950_abnormal_plasma_membrane3.03142675
6MP0004859_abnormal_synaptic_plasticity2.99964164
7MP0004885_abnormal_endolymph2.86230501
8MP0003329_amyloid_beta_deposits2.77694370
9MP0002272_abnormal_nervous_system2.76043131
10MP0001529_abnormal_vocalization2.72791150
11MP0001486_abnormal_startle_reflex2.71674069
12MP0005171_absent_coat_pigmentation2.65738455
13MP0004742_abnormal_vestibular_system2.60698336
14MP0002064_seizures2.54617715
15MP0001905_abnormal_dopamine_level2.40882614
16MP0004142_abnormal_muscle_tone2.39737457
17* MP0003634_abnormal_glial_cell2.27381103
18MP0000778_abnormal_nervous_system2.20764637
19MP0001485_abnormal_pinna_reflex2.20176189
20MP0009046_muscle_twitch2.18840469
21MP0003136_yellow_coat_color2.17817726
22MP0003635_abnormal_synaptic_transmissio2.14377471
23MP0009745_abnormal_behavioral_response2.11406065
24MP0005409_darkened_coat_color2.02768300
25MP0005423_abnormal_somatic_nervous2.00970178
26MP0002734_abnormal_mechanical_nocicepti1.93513647
27MP0003879_abnormal_hair_cell1.93199790
28MP0003632_abnormal_nervous_system1.92175752
29* MP0002229_neurodegeneration1.81152407
30MP0009780_abnormal_chondrocyte_physiolo1.73871976
31MP0005410_abnormal_fertilization1.71167956
32MP0005451_abnormal_body_composition1.67957052
33MP0000955_abnormal_spinal_cord1.62368024
34MP0010678_abnormal_skin_adnexa1.61682549
35MP0000462_abnormal_digestive_system1.60099322
36MP0003787_abnormal_imprinting1.57683591
37MP0000383_abnormal_hair_follicle1.55913721
38MP0002572_abnormal_emotion/affect_behav1.55149981
39MP0002063_abnormal_learning/memory/cond1.53619424
40MP0001440_abnormal_grooming_behavior1.51675049
41MP0004381_abnormal_hair_follicle1.51242175
42MP0008569_lethality_at_weaning1.50387932
43MP0002882_abnormal_neuron_morphology1.48242190
44MP0003631_nervous_system_phenotype1.46970369
45MP0001984_abnormal_olfaction1.45662613
46MP0000604_amyloidosis1.43574700
47MP0005551_abnormal_eye_electrophysiolog1.37886198
48MP0004147_increased_porphyrin_level1.36261763
49MP0002067_abnormal_sensory_capabilities1.35557060
50* MP0002066_abnormal_motor_capabilities/c1.34663505
51MP0005386_behavior/neurological_phenoty1.33071618
52MP0004924_abnormal_behavior1.33071618
53MP0004043_abnormal_pH_regulation1.32317332
54MP0001970_abnormal_pain_threshold1.31808655
55MP0002822_catalepsy1.27032896
56MP0003633_abnormal_nervous_system1.26011385
57MP0005167_abnormal_blood-brain_barrier1.24591151
58MP0000747_muscle_weakness1.24300363
59MP0003123_paternal_imprinting1.23197437
60MP0001963_abnormal_hearing_physiology1.22595644
61MP0003075_altered_response_to1.21466711
62MP0002733_abnormal_thermal_nociception1.20450484
63MP0001299_abnormal_eye_distance/1.18498610
64MP0004134_abnormal_chest_morphology1.17751498
65MP0002752_abnormal_somatic_nervous1.16627901
66MP0005623_abnormal_meninges_morphology1.14762604
67MP0001346_abnormal_lacrimal_gland1.10922601
68MP0008260_abnormal_autophagy1.09163067
69MP0001968_abnormal_touch/_nociception1.05188335
70MP0006276_abnormal_autonomic_nervous1.00574821
71MP0003195_calcinosis0.96167512
72MP0000566_synostosis0.92825899
73MP0001177_atelectasis0.92549450
74MP0005058_abnormal_lysosome_morphology0.92025132
75MP0003122_maternal_imprinting0.91193351
76MP0001501_abnormal_sleep_pattern0.90256449
77MP0002152_abnormal_brain_morphology0.89619081
78MP0004145_abnormal_muscle_electrophysio0.88751894
79MP0003938_abnormal_ear_development0.88108296
80MP0001661_extended_life_span0.87352881
81MP0005195_abnormal_posterior_eye0.85642315
82MP0000647_abnormal_sebaceous_gland0.82527816
83MP0002735_abnormal_chemical_nociception0.81578174
84MP0001851_eye_inflammation0.81451430
85MP0004811_abnormal_neuron_physiology0.80466509
86MP0002184_abnormal_innervation0.78887380
87MP0000026_abnormal_inner_ear0.77566526
88MP0002736_abnormal_nociception_after0.76990055
89MP0003806_abnormal_nucleotide_metabolis0.76497390
90MP0002295_abnormal_pulmonary_circulatio0.74986560
91MP0002557_abnormal_social/conspecific_i0.74359600
92MP0005408_hypopigmentation0.74281136
93MP0001986_abnormal_taste_sensitivity0.73994604
94MP0001348_abnormal_lacrimal_gland0.71643480
95MP0005253_abnormal_eye_physiology0.70384149
96MP0000762_abnormal_tongue_morphology0.70209453
97MP0005535_abnormal_body_temperature0.69724460
98MP0001502_abnormal_circadian_rhythm0.69583765
99MP0006082_CNS_inflammation0.66657895
100MP0006072_abnormal_retinal_apoptosis0.66630084
101MP0003937_abnormal_limbs/digits/tail_de0.65681228
102MP0000579_abnormal_nail_morphology0.65361822
103MP0000467_abnormal_esophagus_morphology0.65096884
104MP0002090_abnormal_vision0.64820335
105MP0003137_abnormal_impulse_conducting0.64609244
106MP0002069_abnormal_eating/drinking_beha0.63361656
107MP0001727_abnormal_embryo_implantation0.59999503
108MP0003172_abnormal_lysosome_physiology0.58913488
109MP0002638_abnormal_pupillary_reflex0.57857866
110MP0002909_abnormal_adrenal_gland0.55838859
111MP0005646_abnormal_pituitary_gland0.55819109
112MP0010769_abnormal_survival0.54494151
113MP0005166_decreased_susceptibility_to0.53766381
114MP0000639_abnormal_adrenal_gland0.52691381
115MP0008874_decreased_physiological_sensi0.52498148
116MP0004133_heterotaxia0.52280673
117MP0008438_abnormal_cutaneous_collagen0.52204688
118MP0002133_abnormal_respiratory_system0.51811326
119MP0010768_mortality/aging0.50924428
120MP0010770_preweaning_lethality0.50230360
121MP0002082_postnatal_lethality0.50230360
122MP0002089_abnormal_postnatal_growth/wei0.49637767
123MP0001943_abnormal_respiration0.49459410
124MP0003045_fibrosis0.49012258
125MP0004130_abnormal_muscle_cell0.48962252
126MP0005388_respiratory_system_phenotype0.46954550
127MP0003956_abnormal_body_size0.45976224
128MP0008872_abnormal_physiological_respon0.44146999
129MP0002873_normal_phenotype0.43429163
130MP0001731_abnormal_postnatal_growth0.42646034
131MP0008877_abnormal_DNA_methylation0.41683261

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.45855948
2Degeneration of the lateral corticospinal tracts (HP:0002314)6.45855948
3Neurofibrillary tangles (HP:0002185)6.01386155
4Sensory axonal neuropathy (HP:0003390)5.36007175
5Peripheral hypomyelination (HP:0007182)4.99400504
6Parakeratosis (HP:0001036)4.98548682
7Focal seizures (HP:0007359)4.96192875
8Abnormality of the corticospinal tract (HP:0002492)4.89281740
9Diplopia (HP:0000651)4.76381233
10Abnormality of binocular vision (HP:0011514)4.76381233
11Cerebral hypomyelination (HP:0006808)4.73382905
12Febrile seizures (HP:0002373)4.34076273
13Cerebral inclusion bodies (HP:0100314)4.28070197
14Onion bulb formation (HP:0003383)4.11790993
15Supranuclear gaze palsy (HP:0000605)4.06309535
16Spastic gait (HP:0002064)3.92552433
17Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.81860899
18Alacrima (HP:0000522)3.59445932
19Intention tremor (HP:0002080)3.57990994
20Abnormal auditory evoked potentials (HP:0006958)3.49682391
21Termporal pattern (HP:0011008)3.48691108
22Insidious onset (HP:0003587)3.48691108
23Myokymia (HP:0002411)3.48657270
24Dysmetria (HP:0001310)3.47019412
25Abnormal eating behavior (HP:0100738)3.44303333
26Visual hallucinations (HP:0002367)3.40741780
27Generalized tonic-clonic seizures (HP:0002069)3.32881132
28Postural instability (HP:0002172)3.31506234
29Slow saccadic eye movements (HP:0000514)3.28079145
30Akinesia (HP:0002304)3.20234037
31Obstructive sleep apnea (HP:0002870)3.14801775
32Limb dystonia (HP:0002451)3.13583917
33Ankle clonus (HP:0011448)3.11251557
34Spastic paraparesis (HP:0002313)3.09354905
35Torticollis (HP:0000473)3.07466477
36Mutism (HP:0002300)3.00913393
37Leukodystrophy (HP:0002415)2.97917457
38Urinary bladder sphincter dysfunction (HP:0002839)2.96978791
39Progressive cerebellar ataxia (HP:0002073)2.96300907
40Scanning speech (HP:0002168)2.93657118
41Tetraplegia (HP:0002445)2.91793604
42Hemiplegia (HP:0002301)2.88222614
43Annular pancreas (HP:0001734)2.86943832
44Decreased lacrimation (HP:0000633)2.85993483
45CNS hypomyelination (HP:0003429)2.85929237
46Neuronal loss in central nervous system (HP:0002529)2.84787840
47Truncal ataxia (HP:0002078)2.82760141
48Papilledema (HP:0001085)2.81182141
49Absence seizures (HP:0002121)2.81171777
50Retinal dysplasia (HP:0007973)2.75401602
51Abnormality of the periventricular white matter (HP:0002518)2.75014465
52Delusions (HP:0000746)2.74507187
53Insomnia (HP:0100785)2.72820303
54Dialeptic seizures (HP:0011146)2.70665016
55Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.67417517
56Rigidity (HP:0002063)2.67033537
57Increased serum pyruvate (HP:0003542)2.65368963
58Abnormality of glycolysis (HP:0004366)2.65368963
59Congenital ichthyosiform erythroderma (HP:0007431)2.65357333
60Depression (HP:0000716)2.62878293
61Impaired vibration sensation in the lower limbs (HP:0002166)2.56511556
62Thickened helices (HP:0000391)2.54597069
63Hypoplastic pelvis (HP:0008839)2.54390108
64Segmental peripheral demyelination/remyelination (HP:0003481)2.53645601
65Focal dystonia (HP:0004373)2.53085905
66Dysdiadochokinesis (HP:0002075)2.52567420
67Premature skin wrinkling (HP:0100678)2.51820202
68Increased circulating renin level (HP:0000848)2.50520071
69Apathy (HP:0000741)2.49647780
70Anteriorly placed anus (HP:0001545)2.49108783
71Bradykinesia (HP:0002067)2.48024257
72Morphological abnormality of the inner ear (HP:0011390)2.47442898
73Anxiety (HP:0000739)2.47396289
74Sleep apnea (HP:0010535)2.45540353
75Absent septum pellucidum (HP:0001331)2.42438141
76Rapidly progressive (HP:0003678)2.40236302
77Action tremor (HP:0002345)2.39117413
78Craniofacial dystonia (HP:0012179)2.38996746
79Split foot (HP:0001839)2.34444721
80Hemiparesis (HP:0001269)2.33874007
81Clumsiness (HP:0002312)2.31615854
82Status epilepticus (HP:0002133)2.31182061
83Pheochromocytoma (HP:0002666)2.30666543
84Cerebral hemorrhage (HP:0001342)2.29494844
85Paraparesis (HP:0002385)2.25722937
86Lower limb muscle weakness (HP:0007340)2.25646148
87Stridor (HP:0010307)2.25115588
88Diminished motivation (HP:0000745)2.23500442
89Poor speech (HP:0002465)2.20064858
90Autoamputation (HP:0001218)2.18079659
91Aplasia involving bones of the upper limbs (HP:0009823)2.17996184
92Aplasia of the phalanges of the hand (HP:0009802)2.17996184
93Aplasia involving bones of the extremities (HP:0009825)2.17996184
94Megalencephaly (HP:0001355)2.17445168
95Poor eye contact (HP:0000817)2.17362945
96Coronal craniosynostosis (HP:0004440)2.16826695
97White forelock (HP:0002211)2.16523253
98Atonic seizures (HP:0010819)2.16198152
99Spastic tetraparesis (HP:0001285)2.15585956
100Epileptiform EEG discharges (HP:0011182)2.13716917
101Patchy hypopigmentation of hair (HP:0011365)2.09493342
102Hypomagnesemia (HP:0002917)2.08617535
103Foot dorsiflexor weakness (HP:0009027)2.07432938
104Focal motor seizures (HP:0011153)2.07408135
105Bundle branch block (HP:0011710)2.06940743
106Memory impairment (HP:0002354)2.06705226
107Abnormality of the lower motor neuron (HP:0002366)2.06441410
108Clonus (HP:0002169)2.05710159
109Hypoplasia of the iris (HP:0007676)2.04556659
110Metabolic alkalosis (HP:0200114)2.03300160
111Abnormality of the septum pellucidum (HP:0007375)2.02915860
112Decreased motor nerve conduction velocity (HP:0003431)2.02574014
113Spastic paraplegia (HP:0001258)2.00013879
114Neuroendocrine neoplasm (HP:0100634)1.99441970
115Partial agenesis of the corpus callosum (HP:0001338)1.98714732
116Urinary incontinence (HP:0000020)1.97186110
117Bowel incontinence (HP:0002607)1.97140694
118Impaired smooth pursuit (HP:0007772)1.95898875
119Abnormality of the phalanges of the 2nd finger (HP:0009541)1.93991504
120Paraplegia (HP:0010550)1.93513826
121Distal sensory impairment (HP:0002936)1.93058050
122Infantile muscular hypotonia (HP:0008947)1.92723263
123Hepatosplenomegaly (HP:0001433)1.92356066
124Cupped ear (HP:0000378)1.92325814
125Methylmalonic acidemia (HP:0002912)1.91978559
126Urinary urgency (HP:0000012)1.91638434
127Hammertoe (HP:0001765)1.91115061
128Humeroradial synostosis (HP:0003041)1.90103041
129Synostosis involving the elbow (HP:0003938)1.90103041
130Slow progression (HP:0003677)1.89900251
131Axonal loss (HP:0003447)1.87958212
132Turricephaly (HP:0000262)1.87679178
133Abnormality of the foot musculature (HP:0001436)1.86278746
134Impaired vibratory sensation (HP:0002495)1.85538739
135EEG with generalized epileptiform discharges (HP:0011198)1.84660034
136Esophageal atresia (HP:0002032)1.84341872
137Abnormal large intestine physiology (HP:0012700)1.84271459
138Choreoathetosis (HP:0001266)1.84120296
139Generalized myoclonic seizures (HP:0002123)1.84099038
140Steppage gait (HP:0003376)1.83831328
141Epileptic encephalopathy (HP:0200134)1.81929699
142Morphological abnormality of the pyramidal tract (HP:0002062)1.81910220
143Hypokalemic alkalosis (HP:0001949)1.81359131
144Erythroderma (HP:0001019)1.78595905
145Diminished movement (HP:0002374)1.77397010
146Partial duplication of thumb phalanx (HP:0009944)1.76683587
147Abnormality of saccadic eye movements (HP:0000570)1.74228403
148Peripheral demyelination (HP:0011096)1.73050869
149Muscle fiber splitting (HP:0003555)1.68664666
150Gowers sign (HP:0003391)1.68609234
151Renal Fanconi syndrome (HP:0001994)1.66892239

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.10472626
2OXSR14.53333451
3DAPK23.28823949
4EPHB13.28573725
5TNIK2.87782808
6CDK192.87256980
7BCR2.68317448
8PKN12.58123166
9WNK42.47619874
10PRPF4B2.25931398
11CAMKK12.15661603
12MET2.10535467
13FGFR22.09422166
14WNK12.07484864
15LIMK12.07024506
16PBK2.05315589
17UHMK12.03089242
18NEK62.02159253
19MAPKAPK51.89762078
20ICK1.87968645
21EPHA41.80059736
22CSNK1G31.79609311
23CSNK1A1L1.72659370
24RIPK11.71886023
25NTRK11.65174158
26PAK61.60371630
27RIPK41.57536659
28ROCK21.55186314
29PLK21.54755687
30CAMK2B1.53178732
31PNCK1.51458523
32GRK51.40202904
33CSNK1G21.40148760
34CLK11.37316411
35CSNK1G11.36834114
36CAMK2D1.28098292
37TESK21.27684800
38ALK1.25899642
39LATS21.25177032
40FGR1.22294829
41TYRO31.21531782
42CAMK11.19893322
43SGK2231.17684760
44SGK4941.17684760
45CASK1.15549327
46MARK11.10894648
47DAPK11.05571468
48CAMK2G1.01685222
49MST40.99197235
50CDK140.96151176
51CDK50.94996451
52MAPK120.94770352
53ARAF0.93405098
54SGK20.92995379
55MARK20.88496861
56PAK30.88496840
57CDK150.86324438
58SGK30.85090985
59SIK20.84190470
60PRKCQ0.82996686
61STK380.82742427
62CDK180.81058158
63BMPR20.79160358
64CAMK2A0.79144793
65SGK10.78984638
66CDK11A0.77629976
67DYRK20.76458303
68MAP3K130.73946721
69CAMKK20.73428690
70BRSK10.73190441
71PDPK10.72850473
72KSR20.72139972
73MUSK0.71805670
74IRAK20.71563841
75PRKD10.70925576
76PHKG10.69447897
77PHKG20.69447897
78MAP3K110.66995208
79MAPK150.64923155
80TNK20.64569236
81RPS6KA30.62613678
82NTRK20.61453750
83PRKCE0.59140637
84MAP3K90.58602531
85PRKCZ0.58314150
86MAPK130.57348342
87ERBB40.56636841
88ILK0.56416629
89FES0.54652922
90STK110.52793621
91NTRK30.51641812
92PRKCH0.51417214
93LMTK20.49275458
94CAMK40.48339440
95PRKD30.47852011
96* FYN0.47272747
97KSR10.47242388
98BRAF0.47036759
99CSNK1D0.45837027
100BMPR1B0.45056155
101PRKG10.44635764
102RAF10.42344678
103RET0.41802584
104CSNK1A10.41163144
105MAP3K10.41075784
106PDK10.39422056
107IRAK10.39027402
108PRKG20.38790204
109PAK10.38169440
110MAP3K20.35572618
111PRKCA0.35177125
112TESK10.34993404
113MINK10.34759678
114TRPM70.32970847
115ERBB20.32882381
116PRKACB0.32850340
117ROCK10.31925984
118SRC0.31144356
119PDK20.30767258
120DMPK0.30593072
121RPS6KA50.30550293
122GSK3A0.30483704
123MAPK100.29879262
124PDGFRB0.29467295
125MAP2K40.29396215
126BMX0.28840941
127DAPK30.27020765
128JAK20.26869895
129PRKCB0.26300855
130CAMK1G0.25662860
131PINK10.25445233
132PRKACA0.25184387
133DDR20.24084493
134MAPK70.23619745
135DYRK1A0.23487654
136GRK70.23322011
137PRKCG0.23313083
138MAP2K20.22622948
139PTK2B0.22304984
140INSR0.22159264

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.21903031
2Steroid biosynthesis_Homo sapiens_hsa001004.45123968
3Fatty acid elongation_Homo sapiens_hsa000624.21427528
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.18986392
5Ether lipid metabolism_Homo sapiens_hsa005652.95701661
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.74265473
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.57595189
8Insulin secretion_Homo sapiens_hsa049112.43673115
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.32607754
10Axon guidance_Homo sapiens_hsa043602.12348734
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.92108817
12Sulfur metabolism_Homo sapiens_hsa009201.86272389
13Oxidative phosphorylation_Homo sapiens_hsa001901.76178105
14Sphingolipid metabolism_Homo sapiens_hsa006001.74983724
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74404202
16Vitamin B6 metabolism_Homo sapiens_hsa007501.67779396
17GABAergic synapse_Homo sapiens_hsa047271.63649870
18Glutamatergic synapse_Homo sapiens_hsa047241.60182553
19Protein export_Homo sapiens_hsa030601.54746102
20Serotonergic synapse_Homo sapiens_hsa047261.43929776
21Nitrogen metabolism_Homo sapiens_hsa009101.40303600
22Linoleic acid metabolism_Homo sapiens_hsa005911.39469234
23beta-Alanine metabolism_Homo sapiens_hsa004101.38824100
24Butanoate metabolism_Homo sapiens_hsa006501.37282268
25Morphine addiction_Homo sapiens_hsa050321.33890337
26Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.33137097
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.29580390
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27224155
29Estrogen signaling pathway_Homo sapiens_hsa049151.23853065
30Alzheimers disease_Homo sapiens_hsa050101.23129173
31* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.22511315
32Parkinsons disease_Homo sapiens_hsa050121.20204698
33GnRH signaling pathway_Homo sapiens_hsa049121.18425004
34Long-term depression_Homo sapiens_hsa047301.16992397
35Bile secretion_Homo sapiens_hsa049761.15755104
36Renal cell carcinoma_Homo sapiens_hsa052111.14231817
37Synaptic vesicle cycle_Homo sapiens_hsa047211.13795933
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13134050
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13006647
40Histidine metabolism_Homo sapiens_hsa003401.11497491
41Collecting duct acid secretion_Homo sapiens_hsa049661.09579933
42Vibrio cholerae infection_Homo sapiens_hsa051101.06124800
43Nicotine addiction_Homo sapiens_hsa050331.05377242
44Glioma_Homo sapiens_hsa052141.03942940
45Circadian entrainment_Homo sapiens_hsa047131.02862772
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99408249
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97981248
48Arginine and proline metabolism_Homo sapiens_hsa003300.97895841
49Cocaine addiction_Homo sapiens_hsa050300.96100909
50Tight junction_Homo sapiens_hsa045300.94873684
51Endocytosis_Homo sapiens_hsa041440.93604410
52Sphingolipid signaling pathway_Homo sapiens_hsa040710.92313282
53Melanogenesis_Homo sapiens_hsa049160.92241578
54Thyroid hormone synthesis_Homo sapiens_hsa049180.91567883
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90850018
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.90165610
57Salivary secretion_Homo sapiens_hsa049700.88990047
58Inositol phosphate metabolism_Homo sapiens_hsa005620.86704399
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84677427
60Dopaminergic synapse_Homo sapiens_hsa047280.84051938
61Cardiac muscle contraction_Homo sapiens_hsa042600.82346010
62Cholinergic synapse_Homo sapiens_hsa047250.82117371
63Ras signaling pathway_Homo sapiens_hsa040140.79894790
64Oocyte meiosis_Homo sapiens_hsa041140.79398903
65ErbB signaling pathway_Homo sapiens_hsa040120.77723553
66Rap1 signaling pathway_Homo sapiens_hsa040150.77416795
67Rheumatoid arthritis_Homo sapiens_hsa053230.77090863
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76991815
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76730176
70Gastric acid secretion_Homo sapiens_hsa049710.76480648
71Lysosome_Homo sapiens_hsa041420.74949483
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74780867
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.74198874
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.72442331
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.71997277
76Phototransduction_Homo sapiens_hsa047440.70145912
77Ovarian steroidogenesis_Homo sapiens_hsa049130.70034044
78Fatty acid metabolism_Homo sapiens_hsa012120.68003515
79Arachidonic acid metabolism_Homo sapiens_hsa005900.65278194
80Glutathione metabolism_Homo sapiens_hsa004800.62756018
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62003463
82Dorso-ventral axis formation_Homo sapiens_hsa043200.61350883
83Olfactory transduction_Homo sapiens_hsa047400.60228246
84Autoimmune thyroid disease_Homo sapiens_hsa053200.59877295
85VEGF signaling pathway_Homo sapiens_hsa043700.59810237
86Pancreatic secretion_Homo sapiens_hsa049720.57354556
87Folate biosynthesis_Homo sapiens_hsa007900.57227824
88Amphetamine addiction_Homo sapiens_hsa050310.57188756
89Gap junction_Homo sapiens_hsa045400.56947014
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56654004
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55461408
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54670435
93Type II diabetes mellitus_Homo sapiens_hsa049300.54444760
94Arginine biosynthesis_Homo sapiens_hsa002200.51526866
95Huntingtons disease_Homo sapiens_hsa050160.50973285
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50550960
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50340539
98Phagosome_Homo sapiens_hsa041450.50016048
99cAMP signaling pathway_Homo sapiens_hsa040240.49536013
100Renin secretion_Homo sapiens_hsa049240.49240209
101Long-term potentiation_Homo sapiens_hsa047200.49097295
102Fatty acid biosynthesis_Homo sapiens_hsa000610.48602363
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48237293
104Taste transduction_Homo sapiens_hsa047420.48136033
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48111725
106Mineral absorption_Homo sapiens_hsa049780.47795934
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47360084
108Choline metabolism in cancer_Homo sapiens_hsa052310.47326432
109Circadian rhythm_Homo sapiens_hsa047100.46531779
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45774277
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45035172
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43823605
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43073722
114Glucagon signaling pathway_Homo sapiens_hsa049220.42715194
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42631298
116ABC transporters_Homo sapiens_hsa020100.42323573
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.42309521
118Propanoate metabolism_Homo sapiens_hsa006400.41795173
119Hedgehog signaling pathway_Homo sapiens_hsa043400.41284117
120Oxytocin signaling pathway_Homo sapiens_hsa049210.38879308
121Calcium signaling pathway_Homo sapiens_hsa040200.36995974
122Malaria_Homo sapiens_hsa051440.35953629
123MAPK signaling pathway_Homo sapiens_hsa040100.35519324
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35329355
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35158367
126Alcoholism_Homo sapiens_hsa050340.33129130
127Peroxisome_Homo sapiens_hsa041460.32889098
128Dilated cardiomyopathy_Homo sapiens_hsa054140.32205500
129ECM-receptor interaction_Homo sapiens_hsa045120.31422261
130Prion diseases_Homo sapiens_hsa050200.30795484
131Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30479601
132Metabolic pathways_Homo sapiens_hsa011000.30054722
133mTOR signaling pathway_Homo sapiens_hsa041500.26486014
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25333324
135AMPK signaling pathway_Homo sapiens_hsa041520.24201647
136Wnt signaling pathway_Homo sapiens_hsa043100.23123655

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