MAGEA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1homocysteine metabolic process (GO:0050667)6.80359101
2folic acid-containing compound biosynthetic process (GO:0009396)6.56176028
3nuclear pore complex assembly (GO:0051292)4.87700501
4regulation of translational fidelity (GO:0006450)4.67419959
5mitotic chromosome condensation (GO:0007076)4.65644338
6cysteine metabolic process (GO:0006534)4.63042480
7RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.58315035
8tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.58315035
9pteridine-containing compound biosynthetic process (GO:0042559)4.42757382
10L-serine metabolic process (GO:0006563)4.40346160
11folic acid-containing compound metabolic process (GO:0006760)4.39372935
12mitochondrial RNA metabolic process (GO:0000959)4.33432085
13folic acid metabolic process (GO:0046655)4.32677250
14tetrahydrofolate metabolic process (GO:0046653)4.26567607
15nuclear pore organization (GO:0006999)4.16450633
16ribosome biogenesis (GO:0042254)4.09189446
17IMP biosynthetic process (GO:0006188)4.00622090
18DNA replication initiation (GO:0006270)3.94570424
19serine family amino acid biosynthetic process (GO:0009070)3.88466017
20DNA strand elongation involved in DNA replication (GO:0006271)3.86991714
21DNA replication checkpoint (GO:0000076)3.85076031
22chromosome condensation (GO:0030261)3.81142775
23DNA strand elongation (GO:0022616)3.73454674
24formation of translation preinitiation complex (GO:0001731)3.71085976
25sulfur amino acid catabolic process (GO:0000098)3.70996744
26mitotic sister chromatid segregation (GO:0000070)3.65468503
27transcription from mitochondrial promoter (GO:0006390)3.63662991
28pteridine-containing compound metabolic process (GO:0042558)3.62869161
29rRNA methylation (GO:0031167)3.62357869
30DNA unwinding involved in DNA replication (GO:0006268)3.58300966
31pore complex assembly (GO:0046931)3.57891667
32mitotic nuclear envelope disassembly (GO:0007077)3.56647361
33rRNA modification (GO:0000154)3.56367367
34IMP metabolic process (GO:0046040)3.52873663
35positive regulation of viral genome replication (GO:0045070)3.44175009
36telomere maintenance via semi-conservative replication (GO:0032201)3.40696265
37CENP-A containing nucleosome assembly (GO:0034080)3.40448495
38ribonucleoprotein complex biogenesis (GO:0022613)3.39131369
39sister chromatid segregation (GO:0000819)3.38704669
40nucleosome assembly (GO:0006334)3.30921124
41purine nucleobase biosynthetic process (GO:0009113)3.29259645
42COPII vesicle coating (GO:0048208)3.27816820
43regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.27790886
44DNA packaging (GO:0006323)3.27062446
45membrane disassembly (GO:0030397)3.25272870
46nuclear envelope disassembly (GO:0051081)3.25272870
47microtubule nucleation (GO:0007020)3.24691925
48tRNA aminoacylation for protein translation (GO:0006418)3.22352291
49pseudouridine synthesis (GO:0001522)3.21508837
50response to vitamin A (GO:0033189)3.20543059
51proline biosynthetic process (GO:0006561)3.19508401
52purine nucleotide salvage (GO:0032261)3.19470236
53kinetochore organization (GO:0051383)3.18720594
54regulation of plasminogen activation (GO:0010755)3.18683598
55alpha-amino acid biosynthetic process (GO:1901607)3.15173730
56nucleobase-containing small molecule interconversion (GO:0015949)3.13927699
57COPI coating of Golgi vesicle (GO:0048205)3.12610842
58Golgi transport vesicle coating (GO:0048200)3.12610842
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.11973847
60alternative mRNA splicing, via spliceosome (GO:0000380)3.10720220
61desmosome organization (GO:0002934)3.09067490
62tRNA aminoacylation (GO:0043039)3.08385943
63amino acid activation (GO:0043038)3.08385943
64sulfur amino acid biosynthetic process (GO:0000097)3.01024194
65nucleobase biosynthetic process (GO:0046112)2.98994905
66chromatin remodeling at centromere (GO:0031055)2.98125988
67protoporphyrinogen IX metabolic process (GO:0046501)2.97193036
68urea cycle (GO:0000050)2.97159228
69cellular protein complex localization (GO:0034629)2.96277617
70ribosomal small subunit biogenesis (GO:0042274)2.95067888
71DNA replication-independent nucleosome assembly (GO:0006336)2.94675000
72DNA replication-independent nucleosome organization (GO:0034724)2.94675000
73protein localization to chromosome, centromeric region (GO:0071459)2.94331993
74mitotic metaphase plate congression (GO:0007080)2.91164037
75tRNA modification (GO:0006400)2.90903532
76telomere maintenance via recombination (GO:0000722)2.87772162
77DNA topological change (GO:0006265)2.86709256
78protein-DNA complex assembly (GO:0065004)2.84546157
79nucleosome organization (GO:0034728)2.80542425
80kinetochore assembly (GO:0051382)2.79985145
81regulation of centriole replication (GO:0046599)2.79567490
82ribosome assembly (GO:0042255)2.79342899
83mitotic recombination (GO:0006312)2.78838086
84regulation of translational elongation (GO:0006448)2.75779720
85regulation of histone H3-K27 methylation (GO:0061085)2.74679243
86protein complex localization (GO:0031503)2.73880118
87mitochondrial DNA metabolic process (GO:0032042)2.72904896
88protoporphyrinogen IX biosynthetic process (GO:0006782)2.71372895
89cellular component biogenesis (GO:0044085)2.67963577
90proteasome assembly (GO:0043248)2.67510329
91protein export from nucleus (GO:0006611)2.66560341
92DNA conformation change (GO:0071103)2.66344226
93urea metabolic process (GO:0019627)2.64433373
94ribosomal small subunit assembly (GO:0000028)2.62319468
95deoxyribonucleotide biosynthetic process (GO:0009263)2.59854199
96chromosome segregation (GO:0007059)2.58630101
97glutamine family amino acid biosynthetic process (GO:0009084)2.58354661
98galactose catabolic process (GO:0019388)2.58019761
99regulation of mitotic spindle organization (GO:0060236)2.57432408
100gonadal mesoderm development (GO:0007506)17.8963461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.39848532
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.84716048
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.71310420
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.59871863
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.54049243
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.04319607
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.99558247
8ZNF263_19887448_ChIP-Seq_K562_Human2.97587819
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94042143
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.86563976
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83734479
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.73420668
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.60739222
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.52508538
15XRN2_22483619_ChIP-Seq_HELA_Human2.48621343
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.47839841
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.47545760
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35970363
19AR_21909140_ChIP-Seq_LNCAP_Human2.25834570
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.24706451
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23117746
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.19908986
23DCP1A_22483619_ChIP-Seq_HELA_Human2.13099541
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03763592
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99047688
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.96806600
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.92885045
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91450424
29GABP_19822575_ChIP-Seq_HepG2_Human1.88357079
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78514590
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78492805
32NCOR1_26117541_ChIP-Seq_K562_Human1.77188890
33MYC_22102868_ChIP-Seq_BL_Human1.76785114
34ZFX_18555785_ChIP-Seq_MESCs_Mouse1.75714186
35TTF2_22483619_ChIP-Seq_HELA_Human1.71919384
36KDM5A_27292631_Chip-Seq_BREAST_Human1.70702825
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.68634212
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.66701543
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.64066681
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63905690
41FOXP3_21729870_ChIP-Seq_TREG_Human1.63615430
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58459668
43CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.58326239
44PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.58278647
45TFEB_21752829_ChIP-Seq_HELA_Human1.57296781
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53204722
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53204458
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52803071
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50123777
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.49717618
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47165339
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46128071
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45673237
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45071735
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44273743
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42106126
57VDR_23849224_ChIP-Seq_CD4+_Human1.40761217
58SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.39093788
59ELK1_19687146_ChIP-ChIP_HELA_Human1.38824717
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38418804
61CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.35234920
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34427126
63BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32821671
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32151063
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31782903
66CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.27036262
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25203424
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24465364
69TBX5_21415370_ChIP-Seq_HL-1_Mouse1.24366465
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24153045
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22458503
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21161008
73CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18179595
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10299697
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09960187
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09789576
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08922019
78CIITA_25753668_ChIP-Seq_RAJI_Human1.06830925
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06752557
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02933195
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99342878
82YY1_21170310_ChIP-Seq_MESCs_Mouse0.97450696
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96071651
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95605577
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95280239
86ATF3_27146783_Chip-Seq_COLON_Human0.93929418
87ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93774498
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92150003
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91190097
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91159760
91GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.90039016
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.88198630
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88139400
94GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85068195
95CHD1_26751641_Chip-Seq_LNCaP_Human0.84142256
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.82704755
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82127279
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.81420403
99VDR_21846776_ChIP-Seq_THP-1_Human0.81076742
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80799576

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence4.12888616
2MP0003111_abnormal_nucleus_morphology3.88454904
3MP0010094_abnormal_chromosome_stability3.61668065
4MP0003705_abnormal_hypodermis_morpholog3.59877525
5MP0003693_abnormal_embryo_hatching3.38442025
6MP0004957_abnormal_blastocyst_morpholog3.26598948
7MP0001661_extended_life_span3.23964020
8MP0003786_premature_aging3.07632952
9MP0008058_abnormal_DNA_repair3.06079052
10MP0003077_abnormal_cell_cycle2.77106299
11MP0004147_increased_porphyrin_level2.76721125
12MP0004233_abnormal_muscle_weight2.57906687
13MP0005451_abnormal_body_composition2.52305617
14MP0008057_abnormal_DNA_replication2.38910431
15MP0008932_abnormal_embryonic_tissue2.36537308
16MP0005360_urolithiasis2.33862389
17MP0009697_abnormal_copulation2.33137624
18MP0002396_abnormal_hematopoietic_system2.31251149
19MP0005646_abnormal_pituitary_gland2.30264831
20MP0003186_abnormal_redox_activity2.25397502
21MP0005670_abnormal_white_adipose2.22543627
22MP0004185_abnormal_adipocyte_glucose2.13230234
23MP0005171_absent_coat_pigmentation1.92401585
24MP0003656_abnormal_erythrocyte_physiolo1.90689035
25MP0010307_abnormal_tumor_latency1.83713238
26MP0002877_abnormal_melanocyte_morpholog1.82727370
27MP0003806_abnormal_nucleotide_metabolis1.73991196
28MP0000013_abnormal_adipose_tissue1.72715233
29MP0008007_abnormal_cellular_replicative1.69657079
30MP0000350_abnormal_cell_proliferation1.53012435
31MP0001730_embryonic_growth_arrest1.52256804
32MP0002095_abnormal_skin_pigmentation1.45093909
33MP0009333_abnormal_splenocyte_physiolog1.44276218
34MP0000678_abnormal_parathyroid_gland1.41307894
35MP0002132_abnormal_respiratory_system1.39866648
36MP0003941_abnormal_skin_development1.35242098
37MP0005332_abnormal_amino_acid1.35142890
38MP0001348_abnormal_lacrimal_gland1.34786803
39MP0006035_abnormal_mitochondrial_morpho1.31587439
40MP0000358_abnormal_cell_content/1.29496120
41MP0003718_maternal_effect1.29348618
42MP0001764_abnormal_homeostasis1.29128546
43MP0006036_abnormal_mitochondrial_physio1.27160378
44MP0002080_prenatal_lethality1.26246914
45MP0005083_abnormal_biliary_tract1.26000717
46MP0001697_abnormal_embryo_size1.25686606
47MP0005076_abnormal_cell_differentiation1.24490306
48MP0000313_abnormal_cell_death1.23489277
49MP0002210_abnormal_sex_determination1.19322535
50MP0005408_hypopigmentation1.18139984
51MP0000747_muscle_weakness1.16380953
52MP0002269_muscular_atrophy1.13826132
53MP0005380_embryogenesis_phenotype1.12462496
54MP0001672_abnormal_embryogenesis/_devel1.12462496
55MP0000003_abnormal_adipose_tissue1.11571960
56MP0005058_abnormal_lysosome_morphology1.08888106
57MP0003984_embryonic_growth_retardation1.06583933
58MP0002088_abnormal_embryonic_growth/wei1.03738110
59MP0002938_white_spotting1.03665927
60MP0002160_abnormal_reproductive_system1.01188328
61MP0001929_abnormal_gametogenesis1.00781129
62MP0002086_abnormal_extraembryonic_tissu0.98927104
63MP0001145_abnormal_male_reproductive0.97436986
64MP0000647_abnormal_sebaceous_gland0.93534880
65MP0002019_abnormal_tumor_incidence0.90377571
66MP0000653_abnormal_sex_gland0.88279968
67MP0003942_abnormal_urinary_system0.87057520
68MP0004808_abnormal_hematopoietic_stem0.86931481
69MP0003959_abnormal_lean_body0.85783032
70MP0005636_abnormal_mineral_homeostasis0.84023873
71MP0000371_diluted_coat_color0.79597682
72MP0002009_preneoplasia0.78789876
73MP0002075_abnormal_coat/hair_pigmentati0.78726001
74MP0001186_pigmentation_phenotype0.77975634
75MP0005647_abnormal_sex_gland0.77684286
76MP0003698_abnormal_male_reproductive0.74890269
77MP0001919_abnormal_reproductive_system0.73530111
78MP0000372_irregular_coat_pigmentation0.72577799
79MP0003221_abnormal_cardiomyocyte_apopto0.71379388
80MP0001873_stomach_inflammation0.71208792
81MP0004043_abnormal_pH_regulation0.71105623
82MP0000598_abnormal_liver_morphology0.71021815
83MP0000609_abnormal_liver_physiology0.70644412
84MP0003699_abnormal_female_reproductive0.70271701
85MP0002084_abnormal_developmental_patter0.66642197
86MP0002970_abnormal_white_adipose0.65592959
87MP0010234_abnormal_vibrissa_follicle0.65417568
88MP0000703_abnormal_thymus_morphology0.65253587
89MP0005384_cellular_phenotype0.65082729
90MP0001944_abnormal_pancreas_morphology0.64912628
91MP0009643_abnormal_urine_homeostasis0.63867743
92MP0008438_abnormal_cutaneous_collagen0.63844472
93MP0002161_abnormal_fertility/fecundity0.63086699
94MP0009931_abnormal_skin_appearance0.62842302
95MP0000627_abnormal_mammary_gland0.61491349
96MP0005389_reproductive_system_phenotype0.60380217
97MP0005621_abnormal_cell_physiology0.60022020
98MP0002085_abnormal_embryonic_tissue0.59810592
99MP0000377_abnormal_hair_follicle0.59050043
100MP0001502_abnormal_circadian_rhythm0.58739559

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)5.71356280
2Hyperalaninemia (HP:0003348)5.71356280
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.71356280
4Birth length less than 3rd percentile (HP:0003561)5.10798015
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.23990989
6Chromsome breakage (HP:0040012)4.03110860
7Abnormality of the fetal cardiovascular system (HP:0010948)3.93902592
8Abnormal umbilical cord blood vessels (HP:0011403)3.93902592
9Single umbilical artery (HP:0001195)3.93902592
10Abnormality of homocysteine metabolism (HP:0010919)3.81706896
11Homocystinuria (HP:0002156)3.81706896
12Abnormality of the tricuspid valve (HP:0001702)3.79302634
13White forelock (HP:0002211)3.68186167
14Abnormality of glycolysis (HP:0004366)3.66266894
15Patchy hypopigmentation of hair (HP:0011365)3.62587421
16Hyperthyroidism (HP:0000836)3.59414233
17Increased serum pyruvate (HP:0003542)3.50688711
18Abnormality of pyrimidine metabolism (HP:0004353)3.34540179
19Cholecystitis (HP:0001082)3.23976258
20Abnormal gallbladder physiology (HP:0012438)3.23976258
21Hypertensive crisis (HP:0100735)3.09132282
22Abnormality of the umbilical cord (HP:0010881)3.05949348
23Reticulocytopenia (HP:0001896)2.99507141
24Abnormality of reticulocytes (HP:0004312)2.97941750
25Reticulocytosis (HP:0001923)2.97200249
26Breech presentation (HP:0001623)2.95349904
27Hypoparathyroidism (HP:0000829)2.94152867
28Truncus arteriosus (HP:0001660)2.92677980
29Abnormality of sulfur amino acid metabolism (HP:0004339)2.90215163
30Pallor (HP:0000980)2.87463965
31Ileus (HP:0002595)2.75326992
32Abnormality of serum amino acid levels (HP:0003112)2.70560538
33Abnormality of the heme biosynthetic pathway (HP:0010472)2.61634441
34Ankyloglossia (HP:0010296)2.60085622
35Decreased subcutaneous fat (HP:0001002)2.59676569
36Aplasia/Hypoplasia of the sacrum (HP:0008517)2.59608801
37Cerebral edema (HP:0002181)2.57742371
38Abnormal large intestine physiology (HP:0012700)2.56374066
39Overlapping toe (HP:0001845)2.55370456
40Duplicated collecting system (HP:0000081)2.55297926
41Bowel incontinence (HP:0002607)2.48638570
42Seborrheic dermatitis (HP:0001051)2.46295176
43Breast hypoplasia (HP:0003187)2.41312509
44Abnormality of cochlea (HP:0000375)2.35311683
45Abnormality of the preputium (HP:0100587)2.33906562
46Abnormal mitochondria in muscle tissue (HP:0008316)2.32390303
47Myocardial infarction (HP:0001658)2.30940453
48Esophageal varix (HP:0002040)2.30892001
49Acute encephalopathy (HP:0006846)2.30719514
50Fatigue (HP:0012378)2.30301660
51Arteriovenous malformation (HP:0100026)2.27184629
52Neoplasm of head and neck (HP:0012288)2.22334106
53Esophageal neoplasm (HP:0100751)2.22334106
54Hyperammonemia (HP:0001987)2.22119497
55Abnormality of the renal collecting system (HP:0004742)2.20265909
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.19355549
57Abnormality of cells of the erythroid lineage (HP:0012130)2.19062340
58Premature ovarian failure (HP:0008209)2.17465824
59Cortical visual impairment (HP:0100704)2.17053127
60Constricted visual fields (HP:0001133)2.16557036
61Abnormality of DNA repair (HP:0003254)2.15531129
62Acute necrotizing encephalopathy (HP:0006965)2.14616809
63Cortical dysplasia (HP:0002539)2.14495012
64Abnormality of the carotid arteries (HP:0005344)2.12007875
65Abnormalities of placenta or umbilical cord (HP:0001194)2.10605114
66Increased serum lactate (HP:0002151)2.09235187
67Septate vagina (HP:0001153)2.05755695
68Abnormality of subcutaneous fat tissue (HP:0001001)2.04852446
69Abnormal number of erythroid precursors (HP:0012131)2.04616224
70Complete atrioventricular canal defect (HP:0001674)2.03600822
71Nausea (HP:0002018)2.01579568
72Progressive muscle weakness (HP:0003323)2.01433637
73Squamous cell carcinoma (HP:0002860)1.98136460
74Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.97899176
75Myopathic facies (HP:0002058)1.97302170
76Upper limb muscle weakness (HP:0003484)1.96284345
77Generalized aminoaciduria (HP:0002909)1.92798227
78Hypoalphalipoproteinemia (HP:0003233)1.92145817
79Bone marrow hypocellularity (HP:0005528)1.91549074
80Progressive external ophthalmoplegia (HP:0000590)1.91239814
81Abnormality of methionine metabolism (HP:0010901)1.90763242
82Ureteral duplication (HP:0000073)1.88717851
83Sparse lateral eyebrow (HP:0005338)1.88397373
84Abnormal tarsal ossification (HP:0008369)1.88092521
85Lactic acidosis (HP:0003128)1.87748910
86Polycythemia (HP:0001901)1.87589915
87Abnormality of oral frenula (HP:0000190)1.87382997
88Congenital sensorineural hearing impairment (HP:0008527)1.84900119
89Macrocytic anemia (HP:0001972)1.83703284
90Myelodysplasia (HP:0002863)1.82924702
91Secondary amenorrhea (HP:0000869)1.82158749
92Abnormality of chromosome stability (HP:0003220)1.78204012
93Reduced subcutaneous adipose tissue (HP:0003758)1.76946262
94Short middle phalanx of the 5th finger (HP:0004220)1.75357807
95Premature graying of hair (HP:0002216)1.74320309
96Patellar dislocation (HP:0002999)1.73771137
97Hypopigmentation of the fundus (HP:0007894)1.73420035
98Morphological abnormality of the inner ear (HP:0011390)1.73373260
99Aplasia/Hypoplasia of the earlobes (HP:0009906)1.72956000
100Anorexia (HP:0002039)1.72221781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.78469210
2PBK3.76271067
3PDK23.39901426
4IRAK32.94855528
5NME22.90929321
6NEK12.90914749
7BUB12.83794093
8CCNB12.70053164
9TTK2.64801843
10SCYL22.59134965
11PLK42.41396788
12EEF2K2.31404566
13WEE12.28056025
14TSSK62.25276944
15EIF2AK32.24755369
16RPS6KB22.16507059
17MAP2K32.03849109
18CDC72.03472565
19KSR21.99745662
20ICK1.87839339
21BRSK21.82418970
22CLK11.71391786
23BRSK11.68610172
24PRPF4B1.64687603
25CHEK21.60476940
26ERN11.49026958
27JAK31.47906771
28SRPK11.47461024
29MAP3K31.47266810
30NME11.44818297
31RAF11.33326556
32MAP3K81.31232906
33ATR1.23888682
34PAK41.21883310
35NEK21.20896059
36CDK91.20573504
37BRAF1.15382821
38CDK71.14845705
39BMPR21.12135372
40AURKA1.08064214
41TAOK21.03735547
42MST1R1.02258091
43NTRK31.00831457
44AKT30.98922938
45MAP3K20.97049241
46AURKB0.95117119
47CHEK10.95111882
48PLK10.92131439
49MTOR0.91527565
50SIK10.84722065
51CDK80.84712378
52ALK0.84115348
53MAP2K10.81532321
54STK40.79544055
55KSR10.76292487
56TRIB30.76236195
57CDK120.71342224
58AKT20.70699113
59CDK10.68742747
60PAK10.68385234
61MST40.66926640
62CDK20.65815323
63STK100.64768537
64PLK30.61737176
65NEK60.61047159
66ATM0.58482241
67PRKD30.56351909
68CDK40.53430010
69IRAK20.53233190
70CSNK2A20.52969146
71PRKCI0.50926593
72ARAF0.50117921
73RIPK40.50037376
74CDK30.49239289
75ERBB40.49014501
76BMX0.48816619
77CSNK2A10.44068492
78YES10.43556964
79PTK60.41844283
80LATS20.41723998
81MET0.41432871
82MAP3K10.39958327
83PIM10.39393406
84RPS6KB10.39072488
85ZAK0.37935378
86RPS6KA50.37327442
87ILK0.36259701
88IRAK40.35014855
89PAK20.34424274
90MARK30.34312734
91TESK20.32440242
92MAPK110.32278339
93PKN20.32198653
94EIF2AK20.31367609
95JAK20.30281101
96CSNK1E0.30110386
97MAPK120.28192958
98MAPK140.27489653
99LRRK20.25330910
100AKT10.24583736

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006703.99368081
2DNA replication_Homo sapiens_hsa030303.75283904
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.43323000
4Arginine biosynthesis_Homo sapiens_hsa002202.99376133
5Mismatch repair_Homo sapiens_hsa034302.85756822
6Biosynthesis of amino acids_Homo sapiens_hsa012302.57518738
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.47736032
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.43990932
9Sulfur relay system_Homo sapiens_hsa041222.40458096
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.30763026
11Ribosome_Homo sapiens_hsa030102.17745923
12Homologous recombination_Homo sapiens_hsa034402.11870116
13Spliceosome_Homo sapiens_hsa030402.03561681
14RNA transport_Homo sapiens_hsa030132.02289303
15Proteasome_Homo sapiens_hsa030502.02198747
16Base excision repair_Homo sapiens_hsa034101.98832562
17Nucleotide excision repair_Homo sapiens_hsa034201.85552244
18Cell cycle_Homo sapiens_hsa041101.82919568
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.80545175
20Fanconi anemia pathway_Homo sapiens_hsa034601.77212295
21Pyruvate metabolism_Homo sapiens_hsa006201.75393828
22Folate biosynthesis_Homo sapiens_hsa007901.73563023
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.70960689
24Selenocompound metabolism_Homo sapiens_hsa004501.70582614
25Carbon metabolism_Homo sapiens_hsa012001.68254324
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.66209585
27N-Glycan biosynthesis_Homo sapiens_hsa005101.56336107
28Oxidative phosphorylation_Homo sapiens_hsa001901.54499465
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47786473
30Non-homologous end-joining_Homo sapiens_hsa034501.47204528
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.44692939
32mRNA surveillance pathway_Homo sapiens_hsa030151.43634519
33RNA polymerase_Homo sapiens_hsa030201.39255611
34Pyrimidine metabolism_Homo sapiens_hsa002401.36163989
35Sulfur metabolism_Homo sapiens_hsa009201.34792318
36Galactose metabolism_Homo sapiens_hsa000521.33594695
37Parkinsons disease_Homo sapiens_hsa050121.24473522
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18599653
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.18297676
40Basal transcription factors_Homo sapiens_hsa030221.17442013
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12725191
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11077663
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08507941
44Vitamin B6 metabolism_Homo sapiens_hsa007501.01194914
45Huntingtons disease_Homo sapiens_hsa050161.00309914
46Pentose phosphate pathway_Homo sapiens_hsa000300.99162803
47Vibrio cholerae infection_Homo sapiens_hsa051100.97342834
48Thyroid cancer_Homo sapiens_hsa052160.94460591
49Other glycan degradation_Homo sapiens_hsa005110.94354988
50Collecting duct acid secretion_Homo sapiens_hsa049660.92586811
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88788353
52Purine metabolism_Homo sapiens_hsa002300.82593482
53Arginine and proline metabolism_Homo sapiens_hsa003300.81698352
54Fructose and mannose metabolism_Homo sapiens_hsa000510.80329044
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78837501
56Alcoholism_Homo sapiens_hsa050340.78711915
57RNA degradation_Homo sapiens_hsa030180.78613359
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78147306
59Alzheimers disease_Homo sapiens_hsa050100.77721912
60Steroid biosynthesis_Homo sapiens_hsa001000.77336444
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75037053
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72490638
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.68913248
64Viral carcinogenesis_Homo sapiens_hsa052030.68911704
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.67572852
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66896021
67Glutathione metabolism_Homo sapiens_hsa004800.65731661
68Metabolic pathways_Homo sapiens_hsa011000.62855166
69Fatty acid biosynthesis_Homo sapiens_hsa000610.60023838
70Systemic lupus erythematosus_Homo sapiens_hsa053220.56214391
71Acute myeloid leukemia_Homo sapiens_hsa052210.52473895
72Chronic myeloid leukemia_Homo sapiens_hsa052200.52339223
73Non-small cell lung cancer_Homo sapiens_hsa052230.51522395
74Prion diseases_Homo sapiens_hsa050200.49573079
75Oocyte meiosis_Homo sapiens_hsa041140.43392149
76Bladder cancer_Homo sapiens_hsa052190.43003434
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39229021
78Propanoate metabolism_Homo sapiens_hsa006400.37665442
79p53 signaling pathway_Homo sapiens_hsa041150.36756155
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36435184
81Fatty acid elongation_Homo sapiens_hsa000620.34674205
82Epstein-Barr virus infection_Homo sapiens_hsa051690.31106595
83Synaptic vesicle cycle_Homo sapiens_hsa047210.30111073
84Protein export_Homo sapiens_hsa030600.29553508
85Phenylalanine metabolism_Homo sapiens_hsa003600.28698753
86Tyrosine metabolism_Homo sapiens_hsa003500.26935549
87Pancreatic cancer_Homo sapiens_hsa052120.26492744
88Fatty acid metabolism_Homo sapiens_hsa012120.25127827
89Renal cell carcinoma_Homo sapiens_hsa052110.21340178
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16346789
91AMPK signaling pathway_Homo sapiens_hsa041520.16007830
92Olfactory transduction_Homo sapiens_hsa047400.15785451
93Prostate cancer_Homo sapiens_hsa052150.14917675
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.14327122
95Small cell lung cancer_Homo sapiens_hsa052220.14048872
96HIF-1 signaling pathway_Homo sapiens_hsa040660.14039580
97MicroRNAs in cancer_Homo sapiens_hsa052060.12263471
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.11396652
99Vitamin digestion and absorption_Homo sapiens_hsa049770.10929647
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.09990930

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »