MAGEA10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA methylation involved in gamete generation (GO:0043046)7.49122256
2regulation of female gonad development (GO:2000194)7.48607555
3male meiosis (GO:0007140)6.64075820
4regulation of meiosis I (GO:0060631)6.63452316
5regulation of meiosis (GO:0040020)6.60012877
6behavioral response to nicotine (GO:0035095)6.50983637
7female gamete generation (GO:0007292)6.20684537
8mitotic metaphase plate congression (GO:0007080)5.94768819
9oocyte maturation (GO:0001556)5.94430482
10negative regulation of meiosis (GO:0045835)5.89982916
11histone H2A monoubiquitination (GO:0035518)5.77298475
12meiotic chromosome segregation (GO:0045132)5.69012044
13mitotic chromosome condensation (GO:0007076)5.57136244
14protein K6-linked ubiquitination (GO:0085020)5.55454452
15negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.55072485
16synaptonemal complex assembly (GO:0007130)5.43469549
17attachment of spindle microtubules to kinetochore (GO:0008608)5.40353677
18regulation of exit from mitosis (GO:0007096)5.29494289
19histone H2A ubiquitination (GO:0033522)5.27646840
20regulation of meiotic cell cycle (GO:0051445)5.20648936
21DNA damage induced protein phosphorylation (GO:0006975)5.19502783
22regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.15174862
23meiotic cell cycle (GO:0051321)5.14540876
24synaptonemal complex organization (GO:0070193)5.07122249
25gene silencing by RNA (GO:0031047)5.03143674
26metaphase plate congression (GO:0051310)4.92942801
27negative regulation of smooth muscle cell differentiation (GO:0051151)4.78679147
28base-excision repair, AP site formation (GO:0006285)4.72082446
29regulation of sister chromatid cohesion (GO:0007063)4.65836519
30positive regulation of meiosis (GO:0045836)4.62335528
31meiotic nuclear division (GO:0007126)4.61036700
32DNA deamination (GO:0045006)4.48447493
33establishment of chromosome localization (GO:0051303)4.44904843
34citrulline biosynthetic process (GO:0019240)4.41247089
35positive regulation of meiotic cell cycle (GO:0051446)4.34518061
36response to pheromone (GO:0019236)4.34360450
37mitotic sister chromatid segregation (GO:0000070)4.32239978
38regulation of retinoic acid receptor signaling pathway (GO:0048385)4.32145765
39pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.29084023
40regulation of histone H3-K27 methylation (GO:0061085)4.24391468
41DNA methylation (GO:0006306)4.17951081
42DNA alkylation (GO:0006305)4.17951081
43indolalkylamine metabolic process (GO:0006586)4.16680561
44kynurenine metabolic process (GO:0070189)4.16294178
45platelet dense granule organization (GO:0060155)4.13352530
46glycerophospholipid catabolic process (GO:0046475)4.07670179
47tryptophan catabolic process (GO:0006569)4.04115451
48indole-containing compound catabolic process (GO:0042436)4.04115451
49indolalkylamine catabolic process (GO:0046218)4.04115451
50maturation of 5.8S rRNA (GO:0000460)4.02015783
51meiotic cell cycle process (GO:1903046)4.00703163
52L-fucose catabolic process (GO:0042355)3.99875649
53fucose catabolic process (GO:0019317)3.99875649
54L-fucose metabolic process (GO:0042354)3.99875649
55negative regulation of meiotic cell cycle (GO:0051447)3.94634068
56resolution of meiotic recombination intermediates (GO:0000712)3.88403938
57male meiosis I (GO:0007141)3.85568375
58negative regulation of hormone metabolic process (GO:0032351)3.85266111
59negative regulation of hormone biosynthetic process (GO:0032353)3.85266111
60chromosome segregation (GO:0007059)3.84010916
61regulation of RIG-I signaling pathway (GO:0039535)3.83526615
62ovulation cycle (GO:0042698)3.79920010
63regulation of acrosome reaction (GO:0060046)3.77653137
64chromatin remodeling at centromere (GO:0031055)3.75611489
65CENP-A containing nucleosome assembly (GO:0034080)3.73326877
66mitotic sister chromatid cohesion (GO:0007064)3.72565736
67negative regulation of reproductive process (GO:2000242)3.72539485
68positive regulation of megakaryocyte differentiation (GO:0045654)3.67445532
69sister chromatid cohesion (GO:0007062)3.66401688
70microtubule severing (GO:0051013)3.62704264
71meiosis I (GO:0007127)3.61487029
72tryptophan metabolic process (GO:0006568)3.61184002
73oogenesis (GO:0048477)3.61082938
74reciprocal DNA recombination (GO:0035825)3.59808767
75reciprocal meiotic recombination (GO:0007131)3.59808767
76DNA damage response, signal transduction resulting in transcription (GO:0042772)3.59182977
77regulation of spindle organization (GO:0090224)3.59110571
78DNA replication-independent nucleosome organization (GO:0034724)3.57523634
79DNA replication-independent nucleosome assembly (GO:0006336)3.57523634
80chromosome organization involved in meiosis (GO:0070192)3.56884226
81DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.55868687
82behavioral response to ethanol (GO:0048149)3.51989985
83negative regulation of telomere maintenance (GO:0032205)3.51855716
84chaperone-mediated protein transport (GO:0072321)3.51312194
85regulation of chromosome segregation (GO:0051983)3.48146175
86cellular ketone body metabolic process (GO:0046950)3.47356327
87pyrimidine nucleotide catabolic process (GO:0006244)3.46936423
88sister chromatid segregation (GO:0000819)3.44771641
89histone exchange (GO:0043486)3.44668720
90protein localization to chromosome (GO:0034502)3.42840157
91female gonad development (GO:0008585)3.41417790
92respiratory chain complex IV assembly (GO:0008535)3.40195678
93spindle checkpoint (GO:0031577)3.36265123
94protein-cofactor linkage (GO:0018065)3.36069161
95oocyte development (GO:0048599)3.34704497
96type B pancreatic cell development (GO:0003323)3.34551107
97water-soluble vitamin biosynthetic process (GO:0042364)3.33391690
98notochord development (GO:0030903)3.32854096
99sympathetic nervous system development (GO:0048485)3.29120763
100multicellular organism reproduction (GO:0032504)3.28163196
101regulation of mitotic spindle organization (GO:0060236)3.27605783
102phosphatidylglycerol biosynthetic process (GO:0006655)3.27305789
103positive regulation of chromosome segregation (GO:0051984)3.23257690
104detection of light stimulus involved in sensory perception (GO:0050962)3.23093021
105detection of light stimulus involved in visual perception (GO:0050908)3.23093021
106mitotic nuclear envelope disassembly (GO:0007077)3.20889190
107negative regulation of cell division (GO:0051782)3.20572171
108ketone body metabolic process (GO:1902224)3.19151050
109kinetochore assembly (GO:0051382)3.18948197
110preassembly of GPI anchor in ER membrane (GO:0016254)3.18836796
111DNA replication checkpoint (GO:0000076)3.17838080
112regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.17757930
113indole-containing compound metabolic process (GO:0042430)3.17216806
114detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.16105539
115negative regulation of nuclear division (GO:0051784)3.15655486
116monoubiquitinated protein deubiquitination (GO:0035520)3.15572288
117negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.15336657
118negative regulation of DNA-templated transcription, elongation (GO:0032785)3.15336657
119negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11465172
120cytochrome complex assembly (GO:0017004)3.10391280
121protein localization to chromosome, centromeric region (GO:0071459)3.10213989
122protein monoubiquitination (GO:0006513)3.09139319
123mitotic spindle checkpoint (GO:0071174)3.08187613
124regulation of transforming growth factor beta2 production (GO:0032909)3.07850142
125membrane disassembly (GO:0030397)3.07104139
126nuclear envelope disassembly (GO:0051081)3.07104139
127amine catabolic process (GO:0009310)3.03869636
128cellular biogenic amine catabolic process (GO:0042402)3.03869636
129regulation of hexokinase activity (GO:1903299)3.01751006
130regulation of glucokinase activity (GO:0033131)3.01751006
131cornea development in camera-type eye (GO:0061303)3.00768280
132epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.00139605
133nonmotile primary cilium assembly (GO:0035058)2.97188835
134primary amino compound metabolic process (GO:1901160)2.97125355
135ubiquinone biosynthetic process (GO:0006744)2.95435909
136signal peptide processing (GO:0006465)2.94317383
137protein complex biogenesis (GO:0070271)2.93738564
138regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.92123776
139mannosylation (GO:0097502)2.92045847
140serotonin metabolic process (GO:0042428)2.88107329
141reflex (GO:0060004)2.87210345
142regulation of action potential (GO:0098900)2.83512256
143RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.82730521
144tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.82730521
145rRNA catabolic process (GO:0016075)2.82311838
146regulation of rhodopsin mediated signaling pathway (GO:0022400)2.81649665
147mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.81193755
148mitochondrial respiratory chain complex I assembly (GO:0032981)2.81193755
149NADH dehydrogenase complex assembly (GO:0010257)2.81193755
150regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.80982346
151regulation of mitotic spindle checkpoint (GO:1903504)2.80982346
152retinal cone cell development (GO:0046549)2.78378973
153peptidyl-histidine modification (GO:0018202)2.78108186
154mitochondrial respiratory chain complex assembly (GO:0033108)2.75361829
155regulation of cilium movement (GO:0003352)2.74442530
156neuronal action potential (GO:0019228)2.74289658
157rhodopsin mediated signaling pathway (GO:0016056)2.73946298
158RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.73362612
159ubiquinone metabolic process (GO:0006743)2.72858249
160regulation of nuclear cell cycle DNA replication (GO:0033262)2.71568691
161positive regulation of fatty acid transport (GO:2000193)2.69928862
162enteric nervous system development (GO:0048484)2.69282313
163cellular response to ATP (GO:0071318)2.65335264
164protein polyglutamylation (GO:0018095)2.63646036
165double-strand break repair via homologous recombination (GO:0000724)2.61302305
166positive regulation of prostaglandin secretion (GO:0032308)2.60909471
167recombinational repair (GO:0000725)2.60485580
168sulfation (GO:0051923)2.59459191
169rRNA modification (GO:0000154)2.58034157
170epithelial cilium movement (GO:0003351)2.56837476
171neural tube formation (GO:0001841)2.53634748
172replication fork processing (GO:0031297)2.53286735
173cilium morphogenesis (GO:0060271)2.53193036
174synapsis (GO:0007129)2.52742036
175protein K11-linked deubiquitination (GO:0035871)2.52298450
176L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.52194654
177synaptic transmission, cholinergic (GO:0007271)2.52061886
178negative regulation of mast cell activation (GO:0033004)2.51917347
179G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.51610250
180dopamine transport (GO:0015872)2.50827894
181photoreceptor cell maintenance (GO:0045494)2.50735926
182axoneme assembly (GO:0035082)2.49205863
183positive regulation of defense response to virus by host (GO:0002230)2.49083027
184protein localization to cilium (GO:0061512)2.48960723
185regulation of telomere maintenance (GO:0032204)2.47483335
186nephron tubule morphogenesis (GO:0072078)2.46691389
187nephron epithelium morphogenesis (GO:0072088)2.46691389
188establishment of protein localization to mitochondrial membrane (GO:0090151)2.45566952
189negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45320183
190proline transport (GO:0015824)2.44842833
191auditory receptor cell stereocilium organization (GO:0060088)2.44312238
192NAD biosynthetic process (GO:0009435)2.44210921
193GPI anchor metabolic process (GO:0006505)2.43857087
194piRNA metabolic process (GO:0034587)11.6906038

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.23109172
2E2F7_22180533_ChIP-Seq_HELA_Human4.72378542
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.45165316
4ZNF274_21170338_ChIP-Seq_K562_Hela4.32651360
5KAP1_22055183_ChIP-Seq_ESCs_Mouse3.75843203
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.65335816
7VDR_22108803_ChIP-Seq_LS180_Human3.58205816
8AR_21909140_ChIP-Seq_LNCAP_Human3.38992100
9SMAD_19615063_ChIP-ChIP_OVARY_Human3.28312101
10SALL1_21062744_ChIP-ChIP_HESCs_Human3.09404062
11GBX2_23144817_ChIP-Seq_PC3_Human2.83448831
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.68205637
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.58317779
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.54409933
15GATA1_26923725_Chip-Seq_HPCs_Mouse2.51078884
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.44179601
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.43996428
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.43598976
19EZH2_22144423_ChIP-Seq_EOC_Human2.33424835
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.26860951
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.20310221
22RNF2_27304074_Chip-Seq_NSC_Mouse2.14709315
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12065841
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99162925
25MYC_18940864_ChIP-ChIP_HL60_Human1.98133531
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.91688615
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.91329891
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.90415334
29LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90146703
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.89011490
31RUNX1_26923725_Chip-Seq_HPCs_Mouse1.82978755
32P300_19829295_ChIP-Seq_ESCs_Human1.82779918
33ER_23166858_ChIP-Seq_MCF-7_Human1.78915085
34IGF1R_20145208_ChIP-Seq_DFB_Human1.73683535
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73200511
36TAF15_26573619_Chip-Seq_HEK293_Human1.72099329
37TP53_22573176_ChIP-Seq_HFKS_Human1.69731962
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68540825
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67819552
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.61210886
41MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.57621406
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55224366
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54985459
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53890649
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52649540
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.50861621
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49532890
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.49002324
49FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47685028
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.47685028
51IRF1_19129219_ChIP-ChIP_H3396_Human1.45468829
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44545430
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44474560
54CBP_20019798_ChIP-Seq_JUKART_Human1.44474560
55GATA3_21867929_ChIP-Seq_TH1_Mouse1.44183970
56BCAT_22108803_ChIP-Seq_LS180_Human1.43000687
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42082571
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.41843035
59VDR_23849224_ChIP-Seq_CD4+_Human1.41022778
60STAT1_17558387_ChIP-Seq_HELA_Human1.40062151
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38381173
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36317928
63TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35980406
64NANOG_19829295_ChIP-Seq_ESCs_Human1.35934141
65SOX2_19829295_ChIP-Seq_ESCs_Human1.35934141
66TCF4_22108803_ChIP-Seq_LS180_Human1.34515661
67NCOR_22424771_ChIP-Seq_293T_Human1.32664535
68REST_21632747_ChIP-Seq_MESCs_Mouse1.32393193
69ELK1_19687146_ChIP-ChIP_HELA_Human1.32207729
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32177447
71SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32047292
72TCF4_23295773_ChIP-Seq_U87_Human1.31527002
73AR_20517297_ChIP-Seq_VCAP_Human1.30947483
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.30634592
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30580137
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30319863
77CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.29638028
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28809335
79AR_25329375_ChIP-Seq_VCAP_Human1.28682459
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28575658
81CDX2_22108803_ChIP-Seq_LS180_Human1.26525800
82PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25867645
83ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24616157
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24536501
85GATA3_21878914_ChIP-Seq_MCF-7_Human1.24375351
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24137305
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.22638247
88HOXB7_26014856_ChIP-Seq_BT474_Human1.22170998
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21776166
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.21439774
91SMAD4_21799915_ChIP-Seq_A2780_Human1.21438928
92ELK4_26923725_Chip-Seq_MESODERM_Mouse1.20654119
93KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19977393
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19142278
95AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18975778
96FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18883230
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18833543
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18432613
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.18145205
100E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16211769
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15972159
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15747616
103SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.15720481
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14813107
105NANOG_21062744_ChIP-ChIP_HESCs_Human1.14273799
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.13999169
107STAT3_18555785_Chip-Seq_ESCs_Mouse1.13819966
108KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11912902
109NFYA_21822215_ChIP-Seq_K562_Human1.11486395
110FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11280393
111EZH2_27294783_Chip-Seq_NPCs_Mouse1.11181542
112RUNX2_22187159_ChIP-Seq_PCA_Human1.11033262
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.10701707
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09262793
115CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08781362
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07078166
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06235356
118STAT3_23295773_ChIP-Seq_U87_Human1.06112496
119E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05400233
120SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04128956
121CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03565285
122NANOG_20526341_ChIP-Seq_ESCs_Human1.03213693
123PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03065996
124ERG_20517297_ChIP-Seq_VCAP_Human1.02669400
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02371320
126RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02017023
127CTCF_18555785_Chip-Seq_ESCs_Mouse1.01789705
128POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00208572
129KLF4_18555785_Chip-Seq_ESCs_Mouse0.99709970
130MYC_19829295_ChIP-Seq_ESCs_Human0.99564232
131HNFA_21074721_ChIP-Seq_CACO-2_Human0.99438213
132FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98411065
133TAF2_19829295_ChIP-Seq_ESCs_Human0.98233769
134KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97379911
135NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97191068
136ERA_21632823_ChIP-Seq_H3396_Human0.96878168
137NMYC_18555785_Chip-Seq_ESCs_Mouse0.96597198
138EWS_26573619_Chip-Seq_HEK293_Human0.96585082
139ESRRB_18555785_Chip-Seq_ESCs_Mouse0.96231290
140RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95323054
141GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95127379
142FOXH1_21741376_ChIP-Seq_EPCs_Human0.94466557
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93491055
144GABP_19822575_ChIP-Seq_HepG2_Human0.92386042
145PRDM14_20953172_ChIP-Seq_ESCs_Human0.92360679
146REST_18959480_ChIP-ChIP_MESCs_Mouse0.92123143
147EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92011685
148FOXP3_21729870_ChIP-Seq_TREG_Human0.91733484
149PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91521691
150GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.91413812
151ZFX_18555785_Chip-Seq_ESCs_Mouse0.90960325
152ESR1_20079471_ChIP-ChIP_T-47D_Human0.89575886
153ETV1_20927104_ChIP-Seq_GIST48_Human0.89349532
154SOX2_18555785_Chip-Seq_ESCs_Mouse0.88850555
155FUS_26573619_Chip-Seq_HEK293_Human0.88520171
156TP63_19390658_ChIP-ChIP_HaCaT_Human0.87559383
157NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87118901
158OCT4_18555785_Chip-Seq_ESCs_Mouse0.86148284
159TBL1_22424771_ChIP-Seq_293T_Human0.85967082
160CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.85549065
161POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85285628
162TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85285628
163CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85263575
164RBPJ_21746931_ChIP-Seq_IB4_Human0.84705346
165FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84393916
166GATA3_26560356_Chip-Seq_TH1_Human0.84391205
167PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84013176
168TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83873391
169CBX2_22325352_ChIP-Seq_293T-Rex_Human0.83810127
170GF1B_26923725_Chip-Seq_HPCs_Mouse0.83445290
171PHF8_20622853_ChIP-Seq_HELA_Human0.83105074
172CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.82775804
173GATA6_21074721_ChIP-Seq_CACO-2_Human0.81415193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.55670132
2MP0003718_maternal_effect5.78974951
3MP0008877_abnormal_DNA_methylation5.64100185
4MP0005451_abnormal_body_composition4.73911250
5MP0002102_abnormal_ear_morphology3.69584188
6MP0003693_abnormal_embryo_hatching3.56516078
7MP0010094_abnormal_chromosome_stability3.20902220
8MP0001929_abnormal_gametogenesis2.84756577
9MP0002210_abnormal_sex_determination2.82541082
10MP0001119_abnormal_female_reproductive2.77984930
11MP0003699_abnormal_female_reproductive2.75326055
12MP0001968_abnormal_touch/_nociception2.73754524
13MP0003111_abnormal_nucleus_morphology2.71971725
14MP0002653_abnormal_ependyma_morphology2.70421581
15MP0003077_abnormal_cell_cycle2.65688228
16MP0000653_abnormal_sex_gland2.64258146
17MP0005395_other_phenotype2.60958522
18MP0008875_abnormal_xenobiotic_pharmacok2.58673806
19MP0004957_abnormal_blastocyst_morpholog2.51951170
20MP0003123_paternal_imprinting2.48186880
21MP0002736_abnormal_nociception_after2.43894733
22MP0005551_abnormal_eye_electrophysiolog2.43649650
23MP0003195_calcinosis2.40932691
24MP0005646_abnormal_pituitary_gland2.31230230
25MP0000579_abnormal_nail_morphology2.30716079
26MP0002876_abnormal_thyroid_physiology2.30509359
27MP0002822_catalepsy2.28815141
28MP0000372_irregular_coat_pigmentation2.27702391
29MP0003315_abnormal_perineum_morphology2.25425301
30MP0002249_abnormal_larynx_morphology2.24798092
31MP0000569_abnormal_digit_pigmentation2.22694510
32MP0009046_muscle_twitch2.17106970
33MP0008872_abnormal_physiological_respon2.15805135
34MP0001145_abnormal_male_reproductive2.09015999
35MP0009745_abnormal_behavioral_response2.00860632
36MP0005408_hypopigmentation1.96734323
37MP0006292_abnormal_olfactory_placode1.95410547
38MP0006072_abnormal_retinal_apoptosis1.93793847
39MP0002837_dystrophic_cardiac_calcinosis1.89591705
40MP0003937_abnormal_limbs/digits/tail_de1.89588813
41MP0004885_abnormal_endolymph1.89144516
42MP0008995_early_reproductive_senescence1.84562151
43MP0002751_abnormal_autonomic_nervous1.82153397
44MP0003011_delayed_dark_adaptation1.81290519
45MP0002938_white_spotting1.76599706
46MP0005253_abnormal_eye_physiology1.74626630
47MP0003787_abnormal_imprinting1.73861317
48MP0002272_abnormal_nervous_system1.72997048
49MP0008932_abnormal_embryonic_tissue1.71696072
50MP0005645_abnormal_hypothalamus_physiol1.69317141
51MP0005174_abnormal_tail_pigmentation1.67288877
52MP0002161_abnormal_fertility/fecundity1.65981800
53MP0001501_abnormal_sleep_pattern1.64447253
54MP0005187_abnormal_penis_morphology1.60688106
55MP0001986_abnormal_taste_sensitivity1.59283234
56MP0004133_heterotaxia1.58674586
57MP0003121_genomic_imprinting1.58353898
58MP0003136_yellow_coat_color1.52019267
59MP0002572_abnormal_emotion/affect_behav1.50633571
60MP0005075_abnormal_melanosome_morpholog1.49997815
61MP0006276_abnormal_autonomic_nervous1.46995048
62MP0001529_abnormal_vocalization1.45947815
63MP0004043_abnormal_pH_regulation1.44564713
64MP0004147_increased_porphyrin_level1.43927767
65MP0004142_abnormal_muscle_tone1.40117268
66MP0003880_abnormal_central_pattern1.38670936
67MP0002735_abnormal_chemical_nociception1.37822318
68MP0004742_abnormal_vestibular_system1.37697136
69MP0003283_abnormal_digestive_organ1.36311285
70MP0005171_absent_coat_pigmentation1.35228407
71MP0004185_abnormal_adipocyte_glucose1.35035931
72MP0001970_abnormal_pain_threshold1.33091629
73MP0005423_abnormal_somatic_nervous1.32504053
74MP0003698_abnormal_male_reproductive1.30804190
75MP0001730_embryonic_growth_arrest1.30634767
76MP0002557_abnormal_social/conspecific_i1.29609313
77MP0002733_abnormal_thermal_nociception1.29143906
78MP0008058_abnormal_DNA_repair1.26747000
79MP0003786_premature_aging1.26149687
80MP0002085_abnormal_embryonic_tissue1.23802906
81MP0002064_seizures1.23275363
82MP0002138_abnormal_hepatobiliary_system1.19771661
83MP0002095_abnormal_skin_pigmentation1.19581550
84MP0001486_abnormal_startle_reflex1.18471667
85MP0000350_abnormal_cell_proliferation1.17066587
86MP0001485_abnormal_pinna_reflex1.15156957
87MP0000462_abnormal_digestive_system1.14093808
88MP0002254_reproductive_system_inflammat1.13699297
89MP0004924_abnormal_behavior1.12975173
90MP0005386_behavior/neurological_phenoty1.12975173
91MP0009697_abnormal_copulation1.12136870
92MP0000678_abnormal_parathyroid_gland1.10747961
93MP0000639_abnormal_adrenal_gland1.10435963
94MP0008260_abnormal_autophagy1.07626960
95MP0005310_abnormal_salivary_gland1.07521500
96MP0000631_abnormal_neuroendocrine_gland1.07232419
97MP0002067_abnormal_sensory_capabilities1.05981002
98MP0000230_abnormal_systemic_arterial1.05935644
99MP0000538_abnormal_urinary_bladder1.05867136
100MP0002063_abnormal_learning/memory/cond1.03043602
101MP0005257_abnormal_intraocular_pressure1.02962999
102MP0000647_abnormal_sebaceous_gland1.01905129
103MP0002734_abnormal_mechanical_nocicepti1.01014105
104MP0002160_abnormal_reproductive_system0.99525103
105MP0000613_abnormal_salivary_gland0.99020925
106MP0010368_abnormal_lymphatic_system0.98976979
107MP0005410_abnormal_fertilization0.98531747
108MP0005084_abnormal_gallbladder_morpholo0.97301711
109MP0003635_abnormal_synaptic_transmissio0.96984313
110MP0001905_abnormal_dopamine_level0.96787232
111MP0000015_abnormal_ear_pigmentation0.95986425
112MP0002277_abnormal_respiratory_mucosa0.95065648
113MP0001697_abnormal_embryo_size0.94607129
114MP0002084_abnormal_developmental_patter0.93923129
115MP0002282_abnormal_trachea_morphology0.92472206
116MP0002229_neurodegeneration0.88721153
117MP0001984_abnormal_olfaction0.87561074
118MP0005195_abnormal_posterior_eye0.87267360
119MP0008007_abnormal_cellular_replicative0.87053545
120MP0002019_abnormal_tumor_incidence0.86099533
121MP0001346_abnormal_lacrimal_gland0.85686147
122MP0001324_abnormal_eye_pigmentation0.84794524
123MP0008775_abnormal_heart_ventricle0.84588495
124MP0002752_abnormal_somatic_nervous0.84199967
125MP0001764_abnormal_homeostasis0.83984503
126MP0002184_abnormal_innervation0.83532206
127MP0005360_urolithiasis0.82826278
128MP0005380_embryogenesis_phenotype0.82293694
129MP0001672_abnormal_embryogenesis/_devel0.82293694
130MP0005167_abnormal_blood-brain_barrier0.80861134
131MP0003755_abnormal_palate_morphology0.79797189
132MP0001915_intracranial_hemorrhage0.78201865
133MP0005379_endocrine/exocrine_gland_phen0.77290114
134MP0005085_abnormal_gallbladder_physiolo0.76438760
135MP0002693_abnormal_pancreas_physiology0.75785455
136MP0000427_abnormal_hair_cycle0.74838275
137MP0010386_abnormal_urinary_bladder0.74799274
138MP0000383_abnormal_hair_follicle0.74600195
139MP0010234_abnormal_vibrissa_follicle0.73757045
140MP0009384_cardiac_valve_regurgitation0.73539602
141MP0004215_abnormal_myocardial_fiber0.73503515
142MP0002295_abnormal_pulmonary_circulatio0.71443313
143MP0003950_abnormal_plasma_membrane0.70391021
144MP0000490_abnormal_crypts_of0.67004414
145MP0005647_abnormal_sex_gland0.66894804
146MP0002163_abnormal_gland_morphology0.65708073
147MP0002332_abnormal_exercise_endurance0.64349917
148MP0008057_abnormal_DNA_replication0.64279697
149MP0003890_abnormal_embryonic-extraembry0.63335932
150MP0004510_myositis0.63024258
151MP0005389_reproductive_system_phenotype0.60840391
152MP0003453_abnormal_keratinocyte_physiol0.59893421
153MP0001502_abnormal_circadian_rhythm0.58618209
154MP0005621_abnormal_cell_physiology0.57594807
155MP0002638_abnormal_pupillary_reflex0.56533518
156MP0009250_abnormal_appendicular_skeleto0.56167440
157MP0002139_abnormal_hepatobiliary_system0.56028138
158MP0004145_abnormal_muscle_electrophysio0.55974532
159MP0002080_prenatal_lethality0.55430454
160MP0004036_abnormal_muscle_relaxation0.54913717
161MP0003942_abnormal_urinary_system0.53252772
162MP0002116_abnormal_craniofacial_bone0.51615420
163MP0002877_abnormal_melanocyte_morpholog0.49617623
164MP0003935_abnormal_craniofacial_develop0.48750695
165MP0002109_abnormal_limb_morphology0.48661143
166MP0003984_embryonic_growth_retardation0.48380031
167MP0002177_abnormal_outer_ear0.47110329
168MP0004264_abnormal_extraembryonic_tissu0.46072096
169MP0003861_abnormal_nervous_system0.45015413
170MP0002088_abnormal_embryonic_growth/wei0.43699519
171MP0000432_abnormal_head_morphology0.43122964
172MP0003656_abnormal_erythrocyte_physiolo0.42818027
173MP0001919_abnormal_reproductive_system0.42697998
174MP0002269_muscular_atrophy0.42130720
175MP0002233_abnormal_nose_morphology0.40864252
176MP0002127_abnormal_cardiovascular_syste0.40134242
177MP0002168_other_aberrant_phenotype0.40007856

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)8.49002382
2Chromsome breakage (HP:0040012)5.09519125
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.68748860
4Pancreatic cysts (HP:0001737)4.57493265
5Papillary thyroid carcinoma (HP:0002895)4.53756537
6Premature ovarian failure (HP:0008209)4.51363799
7Secondary amenorrhea (HP:0000869)4.41823516
8Cortical dysplasia (HP:0002539)4.30482885
9Breast hypoplasia (HP:0003187)4.29791958
10Molar tooth sign on MRI (HP:0002419)4.26402652
11Abnormality of midbrain morphology (HP:0002418)4.26402652
12Adrenal hypoplasia (HP:0000835)4.25879672
13Congenital stationary night blindness (HP:0007642)4.22700333
14Facial hemangioma (HP:0000329)4.22448997
15Infertility (HP:0000789)4.20910227
16Flat capital femoral epiphysis (HP:0003370)4.11162528
17Shawl scrotum (HP:0000049)4.08593686
18Birth length less than 3rd percentile (HP:0003561)3.97668153
19True hermaphroditism (HP:0010459)3.90474069
20Patellar aplasia (HP:0006443)3.73181319
21Type II lissencephaly (HP:0007260)3.65103243
22Abnormality of the fovea (HP:0000493)3.64589556
23Azoospermia (HP:0000027)3.63229144
24Nephronophthisis (HP:0000090)3.59621869
25Pulmonary fibrosis (HP:0002206)3.48533668
26Abnormality of the labia minora (HP:0012880)3.45727902
27Aplasia/Hypoplasia of the breasts (HP:0010311)3.43491593
28Aplasia/Hypoplasia of the patella (HP:0006498)3.41647286
29Breast aplasia (HP:0100783)3.41261243
30Abnormal spermatogenesis (HP:0008669)3.39307556
31Attenuation of retinal blood vessels (HP:0007843)3.36920072
32Aplasia/Hypoplasia of the fovea (HP:0008060)3.36866008
33Hypoplasia of the fovea (HP:0007750)3.36866008
34Hypergonadotropic hypogonadism (HP:0000815)3.35637572
35Abnormality of the renal medulla (HP:0100957)3.22548850
36Capillary hemangiomas (HP:0005306)3.21860691
37Abnormality of the renal cortex (HP:0011035)3.21415809
38Abolished electroretinogram (ERG) (HP:0000550)3.06190548
39Large for gestational age (HP:0001520)3.05262799
40Chronic hepatic failure (HP:0100626)2.98966044
41Cystic liver disease (HP:0006706)2.96625437
42Supernumerary spleens (HP:0009799)2.96625050
43Medial flaring of the eyebrow (HP:0010747)2.95034765
44Hypothermia (HP:0002045)2.91181630
45Arterial tortuosity (HP:0005116)2.83374619
46Primary amenorrhea (HP:0000786)2.82136899
47Abnormal rod and cone electroretinograms (HP:0008323)2.78467554
48Tubular atrophy (HP:0000092)2.75334236
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.75303413
50Abnormality of chromosome segregation (HP:0002916)2.75154584
51Abnormality of chromosome stability (HP:0003220)2.75052733
52Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.65634172
53Abnormality of alanine metabolism (HP:0010916)2.65634172
54Hyperalaninemia (HP:0003348)2.65634172
55Anosmia (HP:0000458)2.64482902
56Pendular nystagmus (HP:0012043)2.59108627
57Nonprogressive disorder (HP:0003680)2.56474788
58Abnormality of the fingertips (HP:0001211)2.54480996
59Gaze-evoked nystagmus (HP:0000640)2.53637269
60Sandal gap (HP:0001852)2.52757261
61Hyperventilation (HP:0002883)2.52403088
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.51265674
63Congenital, generalized hypertrichosis (HP:0004540)2.50723966
64Anterior segment dysgenesis (HP:0007700)2.49934159
65Sclerocornea (HP:0000647)2.47964295
66Keratoconus (HP:0000563)2.46134495
67Increased corneal curvature (HP:0100692)2.46134495
68Oligodactyly (hands) (HP:0001180)2.45612384
69Decreased electroretinogram (ERG) amplitude (HP:0000654)2.45229456
70Furrowed tongue (HP:0000221)2.44938685
71Overlapping toe (HP:0001845)2.44729039
72Vascular tortuosity (HP:0004948)2.44619290
73Abnormality of the phalanges of the hallux (HP:0010057)2.44162147
74Lissencephaly (HP:0001339)2.43933183
75Abnormality of placental membranes (HP:0011409)2.43905854
76Amniotic constriction ring (HP:0009775)2.43905854
77Hypoplasia of the pons (HP:0012110)2.43381659
78Abnormality of the pons (HP:0007361)2.41977917
79Absent radius (HP:0003974)2.41704330
80Oligodactyly (HP:0012165)2.40871308
81Carpal bone hypoplasia (HP:0001498)2.39778277
82Bile duct proliferation (HP:0001408)2.38953397
83Abnormal biliary tract physiology (HP:0012439)2.38953397
84Insulin-resistant diabetes mellitus (HP:0000831)2.38460685
85Type 2 muscle fiber atrophy (HP:0003554)2.38314271
86Abnormality of the preputium (HP:0100587)2.37949151
87Polydipsia (HP:0001959)2.37846948
88Abnormal drinking behavior (HP:0030082)2.37846948
89Aplasia involving forearm bones (HP:0009822)2.36489825
90Absent forearm bone (HP:0003953)2.36489825
91Cerebellar dysplasia (HP:0007033)2.36169450
92Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35741854
93Meckel diverticulum (HP:0002245)2.35551287
94Cystic hygroma (HP:0000476)2.34083300
95Severe muscular hypotonia (HP:0006829)2.34005682
96Occipital encephalocele (HP:0002085)2.33899652
97Spondylolisthesis (HP:0003302)2.33833793
98Muscle fiber atrophy (HP:0100295)2.33439099
99Aplastic anemia (HP:0001915)2.33207924
100Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.32917999
101Aplasia/Hypoplasia of the spleen (HP:0010451)2.32751777
102Acute myeloid leukemia (HP:0004808)2.31802346
103Thyroid carcinoma (HP:0002890)2.31617595
104Ketoacidosis (HP:0001993)2.31445815
105Inability to walk (HP:0002540)2.30087130
106Progressive inability to walk (HP:0002505)2.28275989
107Midline defect of the nose (HP:0004122)2.26613505
108Renal cortical cysts (HP:0000803)2.25576891
109Gait imbalance (HP:0002141)2.24133748
110Hypogonadotrophic hypogonadism (HP:0000044)2.23152524
111Aplasia/Hypoplasia of the macula (HP:0008059)2.22578784
112Increased CSF lactate (HP:0002490)2.18772929
113Acute necrotizing encephalopathy (HP:0006965)2.18445485
114Retinal dysplasia (HP:0007973)2.18318437
115Wrist flexion contracture (HP:0001239)2.17971277
1163-Methylglutaconic aciduria (HP:0003535)2.17225760
117Anencephaly (HP:0002323)2.16537596
118Abnormality of the ileum (HP:0001549)2.15385756
119Neuroendocrine neoplasm (HP:0100634)2.15199742
120Mitochondrial inheritance (HP:0001427)2.13416444
121Rib fusion (HP:0000902)2.12955827
122Congenital primary aphakia (HP:0007707)2.12452982
123Abnormality of lateral ventricle (HP:0030047)2.12048599
124Abnormality of the epiphysis of the femoral head (HP:0010574)2.11511427
125Hypoplasia of the uterus (HP:0000013)2.10891209
126Aplasia/Hypoplasia involving the musculature (HP:0001460)2.08890800
127Chronic bronchitis (HP:0004469)2.08331679
128Delayed puberty (HP:0000823)2.07431372
129Ectopic kidney (HP:0000086)2.06564531
130Optic disc pallor (HP:0000543)2.05941554
131Aplasia/hypoplasia of the uterus (HP:0008684)2.05575280
132Atelectasis (HP:0100750)2.05541520
133Acute encephalopathy (HP:0006846)2.05520583
134Small intestinal stenosis (HP:0012848)2.05083436
135Duodenal stenosis (HP:0100867)2.05083436
136Male pseudohermaphroditism (HP:0000037)2.04779318
137Concave nail (HP:0001598)2.03868308
138Decreased central vision (HP:0007663)2.03849124
139Congenital hepatic fibrosis (HP:0002612)2.02376277
140Ketosis (HP:0001946)2.00481063
141Oral leukoplakia (HP:0002745)1.97796574
142Sloping forehead (HP:0000340)1.97675045
143Progressive macrocephaly (HP:0004481)1.97576988
144Short thumb (HP:0009778)1.96936468
145Absent hand (HP:0004050)1.95840992
146Asplenia (HP:0001746)1.95526808
147Nephrogenic diabetes insipidus (HP:0009806)1.94987415
148Aplasia/Hypoplasia of the tongue (HP:0010295)1.94435831
149Aplasia/Hypoplasia affecting the retina (HP:0008061)1.94400272
150Polyuria (HP:0000103)1.94378613
151Malnutrition (HP:0004395)1.93896592
152Abnormality of the femoral head (HP:0003368)1.93888394
153Hypoplastic iliac wings (HP:0002866)1.91841066
154Abnormality of femoral epiphyses (HP:0006499)1.89728407
155Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.89728407
156Bony spicule pigmentary retinopathy (HP:0007737)1.89589555
157Pachygyria (HP:0001302)1.89531122
158Hepatocellular necrosis (HP:0001404)1.88982647
159Rhabdomyosarcoma (HP:0002859)1.88878864
160Camptodactyly of toe (HP:0001836)1.88674393
161Pheochromocytoma (HP:0002666)1.88256162
162Clumsiness (HP:0002312)1.87957568
163Abnormality of macular pigmentation (HP:0008002)1.87534680
164Fetal akinesia sequence (HP:0001989)1.86566526
165Clubbing of toes (HP:0100760)1.85594840
166Pancreatic fibrosis (HP:0100732)1.85562426
167Lip pit (HP:0100267)1.85033236
168Hyperglycemia (HP:0003074)1.84275267
169Cafe-au-lait spot (HP:0000957)1.83161401
170Myelodysplasia (HP:0002863)1.81565103
171Posterior embryotoxon (HP:0000627)1.81453190
172Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81023423
173Arachnodactyly (HP:0001166)1.80624466
174Aplasia/Hypoplasia of the tibia (HP:0005772)1.80226545
175Genital tract atresia (HP:0001827)1.79382876
176Increased serum lactate (HP:0002151)1.78564770
177Hepatic necrosis (HP:0002605)1.77087818
178Fibular aplasia (HP:0002990)1.76721231
179Abnormality of the carotid arteries (HP:0005344)1.75072721
180Vaginal atresia (HP:0000148)1.75015943
181Tachypnea (HP:0002789)1.74491729
182Erectile abnormalities (HP:0100639)1.74351928
183Postaxial foot polydactyly (HP:0001830)1.73742411
184Genetic anticipation (HP:0003743)1.73531603
185Abnormal mitochondria in muscle tissue (HP:0008316)1.70790614
186Optic nerve hypoplasia (HP:0000609)1.70439381
187Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.69098094
188Abnormal protein N-linked glycosylation (HP:0012347)1.69098094
189Abnormal protein glycosylation (HP:0012346)1.69098094
190Abnormal glycosylation (HP:0012345)1.69098094
191Chorioretinal atrophy (HP:0000533)1.69007640
192Lipid accumulation in hepatocytes (HP:0006561)1.68041554
193Abnormal albumin level (HP:0012116)1.67496873
194Hypoalbuminemia (HP:0003073)1.67496873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.48050126
2MAP3K64.56132421
3ERBB44.06929628
4KSR23.99066345
5LATS13.63294059
6EEF2K3.59089854
7ADRBK23.57186402
8LATS23.55271994
9MUSK3.13938859
10ZAK3.03730986
11STK38L3.01943020
12MAP3K92.89951709
13PLK42.85751066
14BRAF2.73437718
15WNK42.72966255
16TTK2.60466602
17TAOK32.56689133
18GRK12.48397889
19TLK12.46693874
20MAP4K22.42752434
21CDK82.40838736
22MAPKAPK32.29639596
23MAP3K132.27170495
24CDC72.20575091
25RAF12.18780263
26INSRR2.13946448
27WNK32.09282002
28PRKD32.08377553
29MOS2.03023440
30ARAF1.97946111
31TXK1.95881785
32TAOK11.81703416
33ACVR1B1.80400299
34MELK1.73944990
35STK31.73604507
36VRK21.68262595
37KSR11.62284312
38NEK21.50334695
39CHEK21.49340588
40STK391.43832544
41OXSR11.43462569
42MAPKAPK51.42953792
43BCKDK1.41559423
44MAP3K41.37814646
45PNCK1.36187477
46PAK61.33349221
47MAPK131.32165832
48AKT31.31423862
49DYRK21.30321765
50PHKG21.29905581
51PHKG11.29905581
52PLK11.28121229
53CASK1.27671654
54DAPK21.21966299
55PAK31.17843834
56CDK91.15737063
57TAF11.10539880
58STK161.08834752
59MKNK21.07958681
60MAP2K71.07955142
61ADRBK11.05058923
62EIF2AK31.04112469
63TGFBR11.01627766
64PLK21.00208727
65TRIM280.98751052
66BMPR20.95047595
67STK240.92058793
68STK100.92005109
69BUB10.91237123
70PRKCG0.91187853
71ABL20.89952692
72TRPM70.89532501
73MAP3K80.89170736
74PRKCE0.88183482
75EIF2AK10.87565117
76CAMKK20.84682552
77PRKD20.84070474
78PKN10.81812493
79MAP2K40.81010175
80MAPK110.76243021
81RPS6KB20.75840124
82DMPK0.75482642
83IRAK10.74712507
84IKBKB0.74141721
85STK380.73227095
86ERBB30.72012012
87TNIK0.70007707
88RET0.68402246
89TYRO30.68191115
90AURKB0.67653949
91AURKA0.66438854
92PRKCI0.66104744
93PTK2B0.64871471
94MST40.64499852
95CSNK1G10.64131674
96FLT30.62534813
97TSSK60.61899174
98MARK10.61267101
99PLK30.59784835
100KIT0.58811391
101BCR0.57867134
102NTRK30.56754213
103PRKAA10.54649378
104BRSK10.54283691
105PDK20.53169759
106CHEK10.51355906
107PRKAA20.50712014
108MAP3K50.50682145
109CDK70.48045919
110MAP3K10.47847536
111NLK0.47650737
112ATM0.46502591
113CSNK1G20.45753744
114TIE10.45508507
115STK110.45179466
116CSNK1G30.44492178
117RPS6KA50.44432184
118CSNK1A10.44036650
119CHUK0.43494328
120MAP2K20.42631188
121MKNK10.42119888
122EIF2AK20.41465911
123FGFR20.41283211
124MARK20.40509004
125MAP3K20.39249143
126BMPR1B0.38066947
127GRK50.37667479
128PRKACA0.37368105
129CDK120.35699320
130PASK0.35247177
131NEK90.34849094
132PIK3CA0.34808244
133MAP2K10.34048905
134PRKCQ0.33968690
135IGF1R0.33463630
136BRSK20.32878514
137LIMK10.32718083
138DYRK30.31745574
139CDK40.31224179
140PRKCA0.30756781
141SYK0.30230560
142MAP2K60.29129462
143CDK10.28956840
144GRK70.28953537
145PINK10.28943399
146CSNK1A1L0.28866818
147DYRK1A0.27213779
148NTRK20.25267189
149VRK10.25006392
150CDK20.23761408
151SGK20.22425364
152ATR0.22212048
153CDK30.21492586
154CAMK2A0.21243679
155JAK30.21042390
156ABL10.20621629
157WEE10.19127529
158HIPK20.18540097
159FGR0.18071875
160CSNK1D0.17227718
161RPS6KA40.14520475
162PAK10.12766183
163SGK4940.11917257
164SGK2230.11917257
165RPS6KA10.09696637
166AKT10.09475017
167JAK20.08567511
168STK40.08244216
169NUAK10.07094345

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041104.06623775
2Basal transcription factors_Homo sapiens_hsa030223.95381791
3Vitamin B6 metabolism_Homo sapiens_hsa007503.67564937
4Ovarian steroidogenesis_Homo sapiens_hsa049133.67019140
5RNA degradation_Homo sapiens_hsa030183.62161437
6Phototransduction_Homo sapiens_hsa047442.80324241
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.76226246
8Homologous recombination_Homo sapiens_hsa034402.71768792
9Circadian rhythm_Homo sapiens_hsa047102.52543798
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.50798763
11Protein export_Homo sapiens_hsa030602.44314546
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.36458529
13Linoleic acid metabolism_Homo sapiens_hsa005912.33370345
14Fanconi anemia pathway_Homo sapiens_hsa034602.30079283
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.29805192
16RNA polymerase_Homo sapiens_hsa030202.25526668
17Selenocompound metabolism_Homo sapiens_hsa004502.24017893
18Oocyte meiosis_Homo sapiens_hsa041142.23246101
19Caffeine metabolism_Homo sapiens_hsa002322.22363691
20Oxidative phosphorylation_Homo sapiens_hsa001902.21814666
21RNA transport_Homo sapiens_hsa030132.18719530
22Pancreatic cancer_Homo sapiens_hsa052122.17639289
23Tryptophan metabolism_Homo sapiens_hsa003802.15002557
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.11045574
25Ether lipid metabolism_Homo sapiens_hsa005652.03871114
26Nitrogen metabolism_Homo sapiens_hsa009102.03728303
27Butanoate metabolism_Homo sapiens_hsa006502.02501570
28Base excision repair_Homo sapiens_hsa034102.02295910
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.01955789
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.97432136
31Dorso-ventral axis formation_Homo sapiens_hsa043201.95189537
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.89372577
33Nucleotide excision repair_Homo sapiens_hsa034201.81795084
34GnRH signaling pathway_Homo sapiens_hsa049121.80858699
35DNA replication_Homo sapiens_hsa030301.75367230
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.72276294
37Mismatch repair_Homo sapiens_hsa034301.71044354
38TGF-beta signaling pathway_Homo sapiens_hsa043501.71036339
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.67235236
40Nicotine addiction_Homo sapiens_hsa050331.65843230
41Proteasome_Homo sapiens_hsa030501.62120083
42Parkinsons disease_Homo sapiens_hsa050121.60591364
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56328465
44p53 signaling pathway_Homo sapiens_hsa041151.46950520
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.43523011
46Non-homologous end-joining_Homo sapiens_hsa034501.42174885
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.41864614
48Colorectal cancer_Homo sapiens_hsa052101.39409100
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.36978210
50Propanoate metabolism_Homo sapiens_hsa006401.35467732
51mRNA surveillance pathway_Homo sapiens_hsa030151.34612404
52Olfactory transduction_Homo sapiens_hsa047401.31735202
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31367390
54Peroxisome_Homo sapiens_hsa041461.30358151
55Choline metabolism in cancer_Homo sapiens_hsa052311.28027832
56Prolactin signaling pathway_Homo sapiens_hsa049171.27711966
57MicroRNAs in cancer_Homo sapiens_hsa052061.17576042
58VEGF signaling pathway_Homo sapiens_hsa043701.17441041
59Renal cell carcinoma_Homo sapiens_hsa052111.14652690
60Taste transduction_Homo sapiens_hsa047421.12960447
61ABC transporters_Homo sapiens_hsa020101.10748313
62mTOR signaling pathway_Homo sapiens_hsa041501.09486242
63Intestinal immune network for IgA production_Homo sapiens_hsa046721.08128164
64Huntingtons disease_Homo sapiens_hsa050161.05270051
65Morphine addiction_Homo sapiens_hsa050321.05057832
66Steroid hormone biosynthesis_Homo sapiens_hsa001401.04701370
67Chemical carcinogenesis_Homo sapiens_hsa052041.03601003
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03245090
69Glycerophospholipid metabolism_Homo sapiens_hsa005641.00845122
70Alzheimers disease_Homo sapiens_hsa050100.99956656
71Bladder cancer_Homo sapiens_hsa052190.99328396
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95011207
73Regulation of autophagy_Homo sapiens_hsa041400.94997402
74Sulfur metabolism_Homo sapiens_hsa009200.93436809
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93406964
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92366774
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90735641
78Long-term depression_Homo sapiens_hsa047300.90708894
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90577304
80Thyroid cancer_Homo sapiens_hsa052160.90526175
81Collecting duct acid secretion_Homo sapiens_hsa049660.89620687
82Pyrimidine metabolism_Homo sapiens_hsa002400.87529775
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.86475864
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86063188
85Cardiac muscle contraction_Homo sapiens_hsa042600.86022592
86Insulin secretion_Homo sapiens_hsa049110.81763307
87Hippo signaling pathway_Homo sapiens_hsa043900.81179790
88beta-Alanine metabolism_Homo sapiens_hsa004100.80855504
89Purine metabolism_Homo sapiens_hsa002300.79957926
90Retinol metabolism_Homo sapiens_hsa008300.77745226
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77370547
92Non-small cell lung cancer_Homo sapiens_hsa052230.77293816
93Endometrial cancer_Homo sapiens_hsa052130.76779843
94FoxO signaling pathway_Homo sapiens_hsa040680.75873185
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75108886
96Adherens junction_Homo sapiens_hsa045200.74295345
97Ras signaling pathway_Homo sapiens_hsa040140.73412911
98Circadian entrainment_Homo sapiens_hsa047130.72558644
99Metabolic pathways_Homo sapiens_hsa011000.72478543
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71187683
101GABAergic synapse_Homo sapiens_hsa047270.70913429
102Fatty acid elongation_Homo sapiens_hsa000620.69404545
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.67975699
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67615685
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67148480
106Inositol phosphate metabolism_Homo sapiens_hsa005620.66324630
107Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65858704
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64305392
109Fatty acid metabolism_Homo sapiens_hsa012120.63086728
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62198323
111Chronic myeloid leukemia_Homo sapiens_hsa052200.61808606
112Primary immunodeficiency_Homo sapiens_hsa053400.61308830
113Histidine metabolism_Homo sapiens_hsa003400.60903641
114Small cell lung cancer_Homo sapiens_hsa052220.60895788
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60756224
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59688480
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56741230
118HTLV-I infection_Homo sapiens_hsa051660.55735249
119Arachidonic acid metabolism_Homo sapiens_hsa005900.55610675
120Asthma_Homo sapiens_hsa053100.53983473
121Notch signaling pathway_Homo sapiens_hsa043300.50956003
122Hepatitis B_Homo sapiens_hsa051610.50327146
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48941102
124Steroid biosynthesis_Homo sapiens_hsa001000.48340765
125Other glycan degradation_Homo sapiens_hsa005110.47971778
126Melanoma_Homo sapiens_hsa052180.47917082
127One carbon pool by folate_Homo sapiens_hsa006700.47622141
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47053031
129Salivary secretion_Homo sapiens_hsa049700.46921862
130Calcium signaling pathway_Homo sapiens_hsa040200.46879751
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46874066
132Fat digestion and absorption_Homo sapiens_hsa049750.46134747
133Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45687101
134Glioma_Homo sapiens_hsa052140.45683392
135Prostate cancer_Homo sapiens_hsa052150.45179510
136Rheumatoid arthritis_Homo sapiens_hsa053230.44088760
137Fatty acid degradation_Homo sapiens_hsa000710.43939473
138Glycerolipid metabolism_Homo sapiens_hsa005610.43831037
139Cyanoamino acid metabolism_Homo sapiens_hsa004600.43152254
140Vitamin digestion and absorption_Homo sapiens_hsa049770.43138459
141Herpes simplex infection_Homo sapiens_hsa051680.42925634
142Folate biosynthesis_Homo sapiens_hsa007900.42769253
143Sulfur relay system_Homo sapiens_hsa041220.41077110
144Shigellosis_Homo sapiens_hsa051310.40520824
145Fatty acid biosynthesis_Homo sapiens_hsa000610.40469555
146Estrogen signaling pathway_Homo sapiens_hsa049150.39551301
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39389678
148Dopaminergic synapse_Homo sapiens_hsa047280.38001779
149ErbB signaling pathway_Homo sapiens_hsa040120.37948484
150Tyrosine metabolism_Homo sapiens_hsa003500.37308963
151Mineral absorption_Homo sapiens_hsa049780.36985405
152MAPK signaling pathway_Homo sapiens_hsa040100.36297587
153Serotonergic synapse_Homo sapiens_hsa047260.34735901
154Epstein-Barr virus infection_Homo sapiens_hsa051690.32131594
155Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28527172
156Sphingolipid metabolism_Homo sapiens_hsa006000.28155256
157Arginine and proline metabolism_Homo sapiens_hsa003300.27458655
158Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26626394
159Lysine degradation_Homo sapiens_hsa003100.21426078
160Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.21370295
161Sphingolipid signaling pathway_Homo sapiens_hsa040710.19793270
162Pathways in cancer_Homo sapiens_hsa052000.19587693
163Glutamatergic synapse_Homo sapiens_hsa047240.19247846
164Vascular smooth muscle contraction_Homo sapiens_hsa042700.18992657
165Wnt signaling pathway_Homo sapiens_hsa043100.17430897
166Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16407126
167cAMP signaling pathway_Homo sapiens_hsa040240.14180910
168Viral carcinogenesis_Homo sapiens_hsa052030.12673588
169Spliceosome_Homo sapiens_hsa030400.11783151
170Insulin signaling pathway_Homo sapiens_hsa049100.11243323
171TNF signaling pathway_Homo sapiens_hsa046680.10279292
172Malaria_Homo sapiens_hsa051440.10034028
173HIF-1 signaling pathway_Homo sapiens_hsa040660.09813703
174Tight junction_Homo sapiens_hsa045300.08791152
175Pyruvate metabolism_Homo sapiens_hsa006200.08721244

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