ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitotic chromosome condensation (GO:0007076)	5.62382695
2	synapsis (GO:0007129)	5.19800753
3	formation of translation preinitiation complex (GO:0001731)	5.08020845
4	COPI coating of Golgi vesicle (GO:0048205)	5.06799711
5	Golgi transport vesicle coating (GO:0048200)	5.06799711
6	chromosome organization involved in meiosis (GO:0070192)	4.80904261
7	ribosome assembly (GO:0042255)	4.72042750
8	synaptonemal complex assembly (GO:0007130)	4.55214195
9	ribosomal small subunit assembly (GO:0000028)	4.25458079
10	resolution of meiotic recombination intermediates (GO:0000712)	4.05841518
11	mitotic metaphase plate congression (GO:0007080)	3.93416386
12	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.93363474
13	nuclear pore complex assembly (GO:0051292)	3.89560675
14	synaptonemal complex organization (GO:0070193)	3.84233718
15	ribosomal small subunit biogenesis (GO:0042274)	3.77555958
16	gonadal mesoderm development (GO:0007506)	3.75364926
17	DNA synthesis involved in DNA repair (GO:0000731)	3.69333914
18	regulation of mitotic spindle organization (GO:0060236)	3.58499419
19	mitotic sister chromatid cohesion (GO:0007064)	3.57853488
20	mitotic sister chromatid segregation (GO:0000070)	3.52450528
21	regulation of translational fidelity (GO:0006450)	3.50726764
22	regulation of mammary gland epithelial cell proliferation (GO:0033599)	3.48775177
23	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	3.41832132
24	metaphase plate congression (GO:0051310)	3.40915522
25	nuclear pore organization (GO:0006999)	3.38979506
26	chromosome condensation (GO:0030261)	3.37568190
27	regulation of early endosome to late endosome transport (GO:2000641)	3.37030180
28	piRNA metabolic process (GO:0034587)	3.36870941
29	regulation of RNA export from nucleus (GO:0046831)	3.35998612
30	male meiosis (GO:0007140)	3.34674532
31	proline biosynthetic process (GO:0006561)	3.31631767
32	sister chromatid segregation (GO:0000819)	3.31626836
33	protein localization to chromosome, centromeric region (GO:0071459)	3.30830210
34	male meiosis I (GO:0007141)	3.30101822
35	protein complex localization (GO:0031503)	3.28353961
36	meiotic nuclear division (GO:0007126)	3.25300493
37	melanin biosynthetic process (GO:0042438)	3.24922703
38	protein maturation by protein folding (GO:0022417)	3.23942996
39	ribosome biogenesis (GO:0042254)	3.21822309
40	ribonucleoprotein complex biogenesis (GO:0022613)	3.21788976
41	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.21696343
42	cellular protein complex localization (GO:0034629)	3.17435900
43	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.17112971
44	DNA packaging (GO:0006323)	3.06259437
45	rRNA modification (GO:0000154)	3.03694278
46	rRNA methylation (GO:0031167)	3.02992802
47	meiosis I (GO:0007127)	3.01723514
48	regulation of spindle organization (GO:0090224)	2.99292785
49	fusion of sperm to egg plasma membrane (GO:0007342)	2.97575759
50	ventricular cardiac muscle cell development (GO:0055015)	2.97150163
51	ribosomal large subunit biogenesis (GO:0042273)	2.96626634
52	CENP-A containing nucleosome assembly (GO:0034080)	2.94458413
53	meiotic cell cycle process (GO:1903046)	2.91503340
54	establishment of chromosome localization (GO:0051303)	2.90294570
55	de novo protein folding (GO:0006458)	2.88952623
56	regulation of nucleobase-containing compound transport (GO:0032239)	2.88311144
57	mitotic cytokinesis (GO:0000281)	2.85825547
58	nucleobase-containing small molecule interconversion (GO:0015949)	2.85792351
59	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	2.84288128
60	de novo posttranslational protein folding (GO:0051084)	2.83643691
61	pore complex assembly (GO:0046931)	2.83365693
62	sister chromatid cohesion (GO:0007062)	2.81546114
63	establishment of integrated proviral latency (GO:0075713)	2.81005118
64	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.80858586
65	regulation of gonadotropin secretion (GO:0032276)	2.80076345
66	mitochondrial fusion (GO:0008053)	2.79942596
67	melanin metabolic process (GO:0006582)	2.79465784
68	histone exchange (GO:0043486)	2.77422348
69	protein localization to kinetochore (GO:0034501)	2.76625610
70	DNA unwinding involved in DNA replication (GO:0006268)	2.74232519
71	meiotic chromosome segregation (GO:0045132)	2.74100168
72	binding of sperm to zona pellucida (GO:0007339)	2.72603889
73	chaperone-mediated protein complex assembly (GO:0051131)	2.71102429
74	mitotic spindle checkpoint (GO:0071174)	2.69815532
75	regulation of chromosome segregation (GO:0051983)	2.69203841
76	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)	2.66530506
77	peptidyl-proline hydroxylation (GO:0019511)	2.64053049
78	mitotic nuclear envelope disassembly (GO:0007077)	2.60507440
79	spindle assembly involved in mitosis (GO:0090307)	2.60131691
80	mitochondrial DNA metabolic process (GO:0032042)	2.58846108
81	DNA replication checkpoint (GO:0000076)	2.58741361
82	microtubule depolymerization (GO:0007019)	2.58436657
83	regulation of translational initiation (GO:0006446)	2.58175643
84	translational initiation (GO:0006413)	2.55372752
85	anterior/posterior axis specification, embryo (GO:0008595)	2.53957735
86	protein retention in ER lumen (GO:0006621)	2.53957375
87	trophoblast giant cell differentiation (GO:0060707)	2.52881067
88	chromatin remodeling at centromere (GO:0031055)	2.52849711
89	mitotic spindle assembly checkpoint (GO:0007094)	2.52153469
90	spindle checkpoint (GO:0031577)	2.49876851
91	chromosome segregation (GO:0007059)	2.48429449
92	positive regulation of translational initiation (GO:0045948)	2.47288541
93	nucleotide transmembrane transport (GO:1901679)	2.46333180
94	negative regulation of DNA repair (GO:0045738)	2.46263905
95	spindle assembly checkpoint (GO:0071173)	2.45891858
96	nuclear envelope disassembly (GO:0051081)	2.45587311
97	membrane disassembly (GO:0030397)	2.45587311
98	proteasome assembly (GO:0043248)	2.44728361
99	mitochondrial fission (GO:0000266)	2.41346511
100	basement membrane organization (GO:0071711)	2.38629731

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.73027824
2	E2F7_22180533_ChIP-Seq_HELA_Human	4.18812935
3	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.72210789
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.61734977
5	ZNF263_19887448_ChIP-Seq_K562_Human	3.22887600
6	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.19762332
7	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.03329661
8	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.00458214
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.90977238
10	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.58060390
11	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.56301261
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.55899225
13	DCP1A_22483619_ChIP-Seq_HELA_Human	2.41322620
14	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.35863279
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.33090638
16	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.27202355
17	AR_21909140_ChIP-Seq_LNCAP_Human	2.21417612
18	ZFX_18555785_ChIP-Seq_MESCs_Mouse	2.20049505
19	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.19389047
20	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	2.18453746
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.16748017
22	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.13458442
23	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.07648441
24	* XRN2_22483619_ChIP-Seq_HELA_Human	2.07138141
25	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.05965246
26	MYCN_18555785_ChIP-Seq_MESCs_Mouse	2.00164543
27	* TTF2_22483619_ChIP-Seq_HELA_Human	1.92856057
28	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.85576944
29	GABP_19822575_ChIP-Seq_HepG2_Human	1.79490684
30	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.69713071
31	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.68790877
32	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.68132850
33	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.67591569
34	TFEB_21752829_ChIP-Seq_HELA_Human	1.66099248
35	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.63411054
36	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.63228064
37	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.60637831
38	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.59360135
39	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.58740229
40	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.58632003
41	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.54430327
42	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.53961104
43	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.53126370
44	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.50031039
45	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.47183539
46	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.47168319
47	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.44750399
48	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.42687514
49	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.42236446
50	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.42154572
51	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.41456292
52	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.38121389
53	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.37493378
54	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.36974533
55	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.36393691
56	KDM5A_27292631_Chip-Seq_BREAST_Human	1.36034641
57	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.35529793
58	ELK1_19687146_ChIP-ChIP_HELA_Human	1.34631404
59	ATF3_27146783_Chip-Seq_COLON_Human	1.33589499
60	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.33362687
61	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.32651519
62	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.32305127
63	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.30994290
64	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.28293597
65	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.26158792
66	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.24756664
67	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.22246595
68	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.22245691
69	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.21079855
70	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.18295159
71	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.17056151
72	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.16443259
73	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.15948728
74	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.15323464
75	RACK7_27058665_Chip-Seq_MCF-7_Human	1.14432085
76	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.14371392
77	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.14360621
78	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.12461668
79	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.09401248
80	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.08854303
81	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.07581606
82	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.06928687
83	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.06875285
84	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.06451532
85	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	1.03811535
86	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.03195826
87	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.03031807
88	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.00880681
89	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.99380992
90	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.99010597
91	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	0.98294852
92	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	0.98070824
93	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	0.98070824
94	VDR_23849224_ChIP-Seq_CD4+_Human	0.97536560
95	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.97429667
96	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.97238527
97	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.97201687
98	CHD1_26751641_Chip-Seq_LNCaP_Human	0.95938963
99	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.95657187
100	FOXP3_21729870_ChIP-Seq_TREG_Human	0.94276951

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	4.17480024
2	MP0002877_abnormal_melanocyte_morpholog	3.50679111
3	MP0010030_abnormal_orbit_morphology	3.04746768
4	MP0004957_abnormal_blastocyst_morpholog	2.97160864
5	MP0005408_hypopigmentation	2.85162506
6	MP0005451_abnormal_body_composition	2.80018282
7	MP0003693_abnormal_embryo_hatching	2.79806581
8	MP0009697_abnormal_copulation	2.76772789
9	MP0003111_abnormal_nucleus_morphology	2.65906227
10	MP0008932_abnormal_embryonic_tissue	2.50448145
11	MP0003077_abnormal_cell_cycle	2.45951158
12	MP0005257_abnormal_intraocular_pressure	2.30370121
13	MP0008058_abnormal_DNA_repair	2.18765618
14	MP0008007_abnormal_cellular_replicative	2.18532282
15	MP0001661_extended_life_span	2.12238740
16	MP0010094_abnormal_chromosome_stability	2.11938636
17	MP0004233_abnormal_muscle_weight	2.05767630
18	MP0000358_abnormal_cell_content/	1.96273046
19	MP0010234_abnormal_vibrissa_follicle	1.93165638
20	MP0008438_abnormal_cutaneous_collagen	1.85341887
21	MP0002210_abnormal_sex_determination	1.74408531
22	MP0005058_abnormal_lysosome_morphology	1.70061087
23	MP0003136_yellow_coat_color	1.68449270
24	MP0003890_abnormal_embryonic-extraembry	1.65093414
25	MP0001730_embryonic_growth_arrest	1.64032308
26	MP0006035_abnormal_mitochondrial_morpho	1.63824370
27	MP0002796_impaired_skin_barrier	1.62728632
28	MP0004858_abnormal_nervous_system	1.60777685
29	MP0005501_abnormal_skin_physiology	1.59674221
30	MP0000350_abnormal_cell_proliferation	1.56179923
31	MP0003941_abnormal_skin_development	1.49557036
32	MP0001929_abnormal_gametogenesis	1.45700775
33	MP0003186_abnormal_redox_activity	1.45499507
34	MP0009053_abnormal_anal_canal	1.43505621
35	MP0004272_abnormal_basement_membrane	1.40977322
36	MP0001348_abnormal_lacrimal_gland	1.39396400
37	MP0002080_prenatal_lethality	1.38801798
38	MP0003566_abnormal_cell_adhesion	1.38285953
39	MP0005380_embryogenesis_phenotype	1.37468190
40	MP0001672_abnormal_embryogenesis/_devel	1.37468190
41	MP0005623_abnormal_meninges_morphology	1.31155107
42	MP0002084_abnormal_developmental_patter	1.29860429
43	MP0002938_white_spotting	1.27925077
44	MP0001145_abnormal_male_reproductive	1.27070653
45	MP0001697_abnormal_embryo_size	1.25285394
46	MP0002060_abnormal_skin_morphology	1.25139649
47	MP0010368_abnormal_lymphatic_system	1.25053802
48	MP0002075_abnormal_coat/hair_pigmentati	1.24353606
49	MP0000537_abnormal_urethra_morphology	1.22366870
50	MP0010352_gastrointestinal_tract_polyps	1.21987879
51	MP0002086_abnormal_extraembryonic_tissu	1.21773203
52	MP0010307_abnormal_tumor_latency	1.21723909
53	MP0004381_abnormal_hair_follicle	1.17283883
54	MP0002085_abnormal_embryonic_tissue	1.16637155
55	MP0003868_abnormal_feces_composition	1.15048052
56	MP0000490_abnormal_crypts_of	1.13585788
57	MP0003984_embryonic_growth_retardation	1.12228685
58	MP0005174_abnormal_tail_pigmentation	1.11456117
59	MP0000653_abnormal_sex_gland	1.09631560
60	MP0003385_abnormal_body_wall	1.08415505
61	MP0002088_abnormal_embryonic_growth/wei	1.07776127
62	MP0002163_abnormal_gland_morphology	1.06686536
63	MP0001186_pigmentation_phenotype	1.04182457
64	MP0003698_abnormal_male_reproductive	1.02915182
65	MP0002095_abnormal_skin_pigmentation	1.02033478
66	MP0000647_abnormal_sebaceous_gland	0.99436805
67	MP0002269_muscular_atrophy	0.98539626
68	MP0000762_abnormal_tongue_morphology	0.97261429
69	MP0003937_abnormal_limbs/digits/tail_de	0.97061833
70	MP0003705_abnormal_hypodermis_morpholog	0.96281809
71	MP0001849_ear_inflammation	0.95930190
72	MP0005384_cellular_phenotype	0.95346808
73	MP0003959_abnormal_lean_body	0.92887692
74	MP0003453_abnormal_keratinocyte_physiol	0.92803195
75	MP0005197_abnormal_uvea_morphology	0.92025282
76	MP0002089_abnormal_postnatal_growth/wei	0.91608062
77	MP0000579_abnormal_nail_morphology	0.89824695
78	MP0003786_premature_aging	0.89648895
79	MP0005621_abnormal_cell_physiology	0.88371180
80	MP0000003_abnormal_adipose_tissue	0.88251234
81	MP0008260_abnormal_autophagy	0.87887527
82	MP0000627_abnormal_mammary_gland	0.86225904
83	MP0000733_abnormal_muscle_development	0.83971029
84	MP0000462_abnormal_digestive_system	0.83395208
85	MP0009840_abnormal_foam_cell	0.82961297
86	MP0000015_abnormal_ear_pigmentation	0.82552175
87	MP0004185_abnormal_adipocyte_glucose	0.82425436
88	MP0005075_abnormal_melanosome_morpholog	0.80674041
89	MP0001915_intracranial_hemorrhage	0.80514273
90	MP0002161_abnormal_fertility/fecundity	0.79714478
91	MP0005330_cardiomyopathy	0.78529841
92	MP0003699_abnormal_female_reproductive	0.77649290
93	MP0002697_abnormal_eye_size	0.76415210
94	MP0000313_abnormal_cell_death	0.76181640
95	MP0004197_abnormal_fetal_growth/weight/	0.75781446
96	MP0003943_abnormal_hepatobiliary_system	0.75777622
97	MP0005076_abnormal_cell_differentiation	0.75449167
98	MP0010771_integument_phenotype	0.75443166
99	MP0003936_abnormal_reproductive_system	0.74995636
100	MP0004264_abnormal_extraembryonic_tissu	0.74744798

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Vertebral compression fractures (HP:0002953)	4.61630938
2	Abnormal auditory evoked potentials (HP:0006958)	4.16287867
3	White forelock (HP:0002211)	3.82403755
4	Abnormality of the distal phalanges of the toes (HP:0010182)	3.65784859
5	Patchy hypopigmentation of hair (HP:0011365)	3.65357667
6	Spastic paraparesis (HP:0002313)	3.31600881
7	Upper limb muscle weakness (HP:0003484)	3.30189492
8	Entropion (HP:0000621)	3.19500673
9	Premature rupture of membranes (HP:0001788)	3.18278144
10	Hand muscle atrophy (HP:0009130)	3.04891245
11	Nuclear cataract (HP:0100018)	3.02780419
12	Short nail (HP:0001799)	2.88036617
13	Paraparesis (HP:0002385)	2.83382712
14	Hypopigmentation of the fundus (HP:0007894)	2.82073368
15	Distal upper limb amyotrophy (HP:0007149)	2.81036825
16	Upper limb amyotrophy (HP:0009129)	2.81036825
17	Abnormal umbilical cord blood vessels (HP:0011403)	2.77400580
18	Single umbilical artery (HP:0001195)	2.77400580
19	Abnormality of the fetal cardiovascular system (HP:0010948)	2.77400580
20	Achilles tendon contracture (HP:0001771)	2.76078608
21	Cutaneous melanoma (HP:0012056)	2.75965929
22	Abnormality of the umbilical cord (HP:0010881)	2.66630011
23	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.61042976
24	Progressive external ophthalmoplegia (HP:0000590)	2.54590277
25	Spinal cord lesions (HP:0100561)	2.51551189
26	Syringomyelia (HP:0003396)	2.51551189
27	Cerebral hypomyelination (HP:0006808)	2.46230040
28	Abnormality of the Achilles tendon (HP:0005109)	2.44154822
29	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.37945468
30	Deviation of the thumb (HP:0009603)	2.35009177
31	Proximal placement of thumb (HP:0009623)	2.34800099
32	Osteolytic defects of the hand bones (HP:0009699)	2.34591162
33	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.34591162
34	Ependymoma (HP:0002888)	2.31452196
35	Back pain (HP:0003418)	2.30597048
36	Down-sloping shoulders (HP:0200021)	2.25408602
37	Poikiloderma (HP:0001029)	2.24576538
38	Elbow flexion contracture (HP:0002987)	2.23854589
39	Absent epiphyses (HP:0010577)	2.23092186
40	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.23092186
41	Flattened epiphyses (HP:0003071)	2.22610188
42	Deep palmar crease (HP:0006191)	2.21153170
43	Protrusio acetabuli (HP:0003179)	2.16165485
44	Increased connective tissue (HP:0009025)	2.15847587
45	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.15834474
46	Reduced antithrombin III activity (HP:0001976)	2.14495326
47	Small epiphyses (HP:0010585)	2.13452085
48	Distal lower limb muscle weakness (HP:0009053)	2.13176255
49	Difficulty climbing stairs (HP:0003551)	2.12481786
50	Neoplasm of the peripheral nervous system (HP:0100007)	2.11138880
51	Ulnar bowing (HP:0003031)	2.09229503
52	Trismus (HP:0000211)	2.06297102
53	Oligodactyly (hands) (HP:0001180)	2.06204727
54	Ankyloglossia (HP:0010296)	2.05119620
55	Increased nuchal translucency (HP:0010880)	2.04027919
56	Abnormality of the lower motor neuron (HP:0002366)	2.02519233
57	Microvesicular hepatic steatosis (HP:0001414)	2.02505386
58	Oligodactyly (HP:0012165)	2.01829835
59	Heterochromia iridis (HP:0001100)	2.01360918
60	Flat acetabular roof (HP:0003180)	2.00490763
61	Shoulder girdle muscle weakness (HP:0003547)	1.99114373
62	Delayed cranial suture closure (HP:0000270)	1.99097116
63	Delayed epiphyseal ossification (HP:0002663)	1.97869396
64	Congenital malformation of the right heart (HP:0011723)	1.96468943
65	Double outlet right ventricle (HP:0001719)	1.96468943
66	Thin bony cortex (HP:0002753)	1.95639274
67	Wormian bones (HP:0002645)	1.95611467
68	Abnormality of oral frenula (HP:0000190)	1.91315907
69	Abnormal trabecular bone morphology (HP:0100671)	1.89221661
70	Leiomyosarcoma (HP:0100243)	1.88702034
71	Uterine leiomyosarcoma (HP:0002891)	1.88702034
72	Distal lower limb amyotrophy (HP:0008944)	1.88616593
73	Septate vagina (HP:0001153)	1.88340294
74	Alacrima (HP:0000522)	1.87702835
75	Fatigue (HP:0012378)	1.86811806
76	Broad distal phalanx of finger (HP:0009836)	1.85447776
77	Selective tooth agenesis (HP:0001592)	1.81050794
78	Elevated alkaline phosphatase (HP:0003155)	1.79213768
79	Limb-girdle muscle atrophy (HP:0003797)	1.77838273
80	Distal sensory impairment (HP:0002936)	1.77257226
81	Chromsome breakage (HP:0040012)	1.76654030
82	Abnormalities of placenta or umbilical cord (HP:0001194)	1.75932757
83	Hypolipoproteinemia (HP:0010981)	1.75509485
84	Tetraparesis (HP:0002273)	1.74548398
85	Hypoalphalipoproteinemia (HP:0003233)	1.73403304
86	Premature skin wrinkling (HP:0100678)	1.72541625
87	Hypobetalipoproteinemia (HP:0003563)	1.72338706
88	Male infertility (HP:0003251)	1.72218504
89	Blue irides (HP:0000635)	1.71484921
90	Ureteral duplication (HP:0000073)	1.71163268
91	Anal stenosis (HP:0002025)	1.71094450
92	Abnormality of the astrocytes (HP:0100707)	1.69960320
93	Astrocytoma (HP:0009592)	1.69960320
94	Dislocated radial head (HP:0003083)	1.69222765
95	Multiple lipomas (HP:0001012)	1.66407719
96	Vertebral arch anomaly (HP:0008438)	1.66398186
97	Abnormal autonomic nervous system physiology (HP:0012332)	1.66016415
98	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.65214197
99	Horseshoe kidney (HP:0000085)	1.64837458
100	Chin dimple (HP:0010751)	1.64593700

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	IRAK3	3.94996947
2	EPHA2	3.36151114
3	NME2	3.20821601
4	SCYL2	2.92080675
5	PBK	2.89201109
6	NEK1	2.88157289
7	BUB1	2.73568742
8	WEE1	2.50859760
9	MST1R	2.39229052
10	LMTK2	2.29416257
11	MET	2.27702133
12	ERBB4	2.27044049
13	TTK	2.22537208
14	PAK4	2.19491825
15	EIF2AK3	1.89720321
16	TSSK6	1.87343275
17	IRAK2	1.82598776
18	PDK2	1.79788336
19	BRAF	1.76576360
20	CDK12	1.69916947
21	EIF2AK1	1.64295036
22	RPS6KB2	1.58262008
23	MAP3K12	1.55556364
24	CDK19	1.46957215
25	PNCK	1.44179076
26	BRSK1	1.43737603
27	PDGFRA	1.29761449
28	NEK2	1.18878557
29	BRSK2	1.17385355
30	PRPF4B	1.16738012
31	PAK6	1.14725800
32	PTK2	1.13898170
33	FLT3	1.12813998
34	TRIB3	1.11864577
35	KSR2	1.09907331
36	TAOK2	1.09315177
37	STK16	1.07931976
38	CLK1	1.05996774
39	KSR1	1.05246487
40	ILK	1.04641583
41	PLK1	1.04387139
42	NTRK1	1.01328021
43	ERN1	0.99217400
44	ICK	0.96107541
45	CHEK2	0.93769423
46	AURKA	0.92691485
47	TESK2	0.92155482
48	TTN	0.91794486
49	SIK3	0.91529940
50	IRAK4	0.89853938
51	SMG1	0.88701409
52	MAP3K8	0.87954041
53	ARAF	0.86784840
54	PAK2	0.83247183
55	CDK8	0.83036486
56	CDK7	0.82739744
57	MAP3K2	0.81401345
58	AURKB	0.80925109
59	DYRK3	0.79648587
60	PRKD3	0.79260490
61	ABL2	0.79104465
62	PDGFRB	0.73572557
63	CDK6	0.72824646
64	ZAK	0.72634634
65	PLK4	0.71914871
66	CCNB1	0.66474418
67	AKT2	0.65947097
68	MOS	0.65643735
69	TESK1	0.64849805
70	IRAK1	0.64391201
71	MTOR	0.64135641
72	CHEK1	0.62179404
73	CDK4	0.62103927
74	SRPK1	0.60301448
75	CDK11A	0.58153534
76	LATS2	0.57475045
77	NEK9	0.57373126
78	ERBB3	0.57158917
79	RAF1	0.55207611
80	LRRK2	0.55206559
81	PIM2	0.53029135
82	MAP3K9	0.52565875
83	ZAP70	0.51356370
84	PRKCI	0.50428239
85	PAK1	0.49925457
86	MAPKAPK3	0.48555198
87	CDK18	0.48200200
88	CDK15	0.47678296
89	PHKG1	0.46973274
90	PHKG2	0.46973274
91	MELK	0.45466429
92	BMPR2	0.45345211
93	CDC7	0.43260587
94	ATR	0.42520597
95	STK10	0.41998247
96	SIK1	0.40372079
97	TRIM28	0.39134168
98	PLK3	0.38340136
99	NEK6	0.37684652
100	TGFBR1	0.37301608

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur relay system_Homo sapiens_hsa04122	3.76151745
2	DNA replication_Homo sapiens_hsa03030	2.94795415
3	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.78861775
4	Mismatch repair_Homo sapiens_hsa03430	2.64967951
5	Nucleotide excision repair_Homo sapiens_hsa03420	2.45152301
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.42870648
7	Cell cycle_Homo sapiens_hsa04110	2.28141805
8	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	2.22776689
9	Ribosome_Homo sapiens_hsa03010	2.21713066
10	N-Glycan biosynthesis_Homo sapiens_hsa00510	2.19426104
11	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.14373113
12	RNA transport_Homo sapiens_hsa03013	2.08332128
13	Proteasome_Homo sapiens_hsa03050	2.05447211
14	p53 signaling pathway_Homo sapiens_hsa04115	2.03107584
15	Pyrimidine metabolism_Homo sapiens_hsa00240	1.91242273
16	Base excision repair_Homo sapiens_hsa03410	1.85340596
17	RNA polymerase_Homo sapiens_hsa03020	1.80392400
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.79870432
19	Spliceosome_Homo sapiens_hsa03040	1.60144618
20	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.53664524
21	Prion diseases_Homo sapiens_hsa05020	1.52875678
22	Folate biosynthesis_Homo sapiens_hsa00790	1.52699398
23	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.51974937
24	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.51942196
25	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.37004842
26	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.35150733
27	Homologous recombination_Homo sapiens_hsa03440	1.29553117
28	Phenylalanine metabolism_Homo sapiens_hsa00360	1.27857447
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.21180708
30	Tyrosine metabolism_Homo sapiens_hsa00350	1.19178015
31	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.17260336
32	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.16605224
33	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.12979767
34	Carbon metabolism_Homo sapiens_hsa01200	1.12876245
35	Pyruvate metabolism_Homo sapiens_hsa00620	1.12779565
36	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.08521576
37	Small cell lung cancer_Homo sapiens_hsa05222	1.07620439
38	mRNA surveillance pathway_Homo sapiens_hsa03015	1.05817821
39	Galactose metabolism_Homo sapiens_hsa00052	1.01736983
40	Pentose phosphate pathway_Homo sapiens_hsa00030	1.00861131
41	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.98137517
42	One carbon pool by folate_Homo sapiens_hsa00670	0.95626278
43	Purine metabolism_Homo sapiens_hsa00230	0.94757146
44	Selenocompound metabolism_Homo sapiens_hsa00450	0.94658975
45	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.93459688
46	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.92290383
47	Basal transcription factors_Homo sapiens_hsa03022	0.91081229
48	Fatty acid elongation_Homo sapiens_hsa00062	0.89143855
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.85656526
50	Lysine degradation_Homo sapiens_hsa00310	0.81701819
51	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.81579105
52	Viral carcinogenesis_Homo sapiens_hsa05203	0.79118381
53	Thyroid cancer_Homo sapiens_hsa05216	0.78439800
54	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.75811977
55	Sulfur metabolism_Homo sapiens_hsa00920	0.75333483
56	ErbB signaling pathway_Homo sapiens_hsa04012	0.70749640
57	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.69797270
58	Pancreatic cancer_Homo sapiens_hsa05212	0.68707629
59	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.68002465
60	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.66201333
61	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.66001029
62	Hippo signaling pathway_Homo sapiens_hsa04390	0.65114557
63	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.64068123
64	Alcoholism_Homo sapiens_hsa05034	0.62788426
65	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.60283580
66	mTOR signaling pathway_Homo sapiens_hsa04150	0.60001961
67	MicroRNAs in cancer_Homo sapiens_hsa05206	0.58910694
68	Glutathione metabolism_Homo sapiens_hsa00480	0.57843325
69	Proteoglycans in cancer_Homo sapiens_hsa05205	0.57640789
70	Oocyte meiosis_Homo sapiens_hsa04114	0.57625596
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.57566032
72	Arginine and proline metabolism_Homo sapiens_hsa00330	0.57318019
73	ECM-receptor interaction_Homo sapiens_hsa04512	0.56143351
74	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.55344743
75	Circadian rhythm_Homo sapiens_hsa04710	0.55238947
76	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.54239631
77	Adherens junction_Homo sapiens_hsa04520	0.53750802
78	Bladder cancer_Homo sapiens_hsa05219	0.53734991
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.52519252
80	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.51455860
81	Insulin signaling pathway_Homo sapiens_hsa04910	0.49994576
82	Arginine biosynthesis_Homo sapiens_hsa00220	0.49775238
83	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.48752794
84	Non-small cell lung cancer_Homo sapiens_hsa05223	0.48394079
85	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.48197297
86	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.46420297
87	Prostate cancer_Homo sapiens_hsa05215	0.45011257
88	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.44699591
89	Shigellosis_Homo sapiens_hsa05131	0.43971122
90	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.42523303
91	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.42521880
92	Apoptosis_Homo sapiens_hsa04210	0.41754188
93	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.41097995
94	beta-Alanine metabolism_Homo sapiens_hsa00410	0.39049031
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38627407
96	Endocytosis_Homo sapiens_hsa04144	0.37865583
97	Renal cell carcinoma_Homo sapiens_hsa05211	0.37548411
98	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.36391756
99	Glioma_Homo sapiens_hsa05214	0.36304998
100	HTLV-I infection_Homo sapiens_hsa05166	0.34778676

MAGEA11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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