MAGEA12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is closely related to several other genes clustered on chromosome X. These genes may be overexpressed in tumors. Multiple alternatively spliced variants encoding the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1homocysteine metabolic process (GO:0050667)8.44193928
2folic acid-containing compound biosynthetic process (GO:0009396)7.13467023
3cysteine metabolic process (GO:0006534)5.31151066
4L-serine metabolic process (GO:0006563)5.26119146
5regulation of plasminogen activation (GO:0010755)5.05652507
6pteridine-containing compound biosynthetic process (GO:0042559)5.03156018
7IMP biosynthetic process (GO:0006188)4.91760439
8nuclear pore complex assembly (GO:0051292)4.86822265
9sulfur amino acid catabolic process (GO:0000098)4.84450596
10ribosome biogenesis (GO:0042254)4.74277447
11mitochondrial RNA metabolic process (GO:0000959)4.69031374
12regulation of translational fidelity (GO:0006450)4.68744513
13folic acid-containing compound metabolic process (GO:0006760)4.67905424
14tetrahydrofolate metabolic process (GO:0046653)4.54828283
15RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.30310948
16tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.30310948
17serine family amino acid biosynthetic process (GO:0009070)4.30066093
18folic acid metabolic process (GO:0046655)4.27574321
19IMP metabolic process (GO:0046040)4.26631971
20desmosome organization (GO:0002934)4.19701415
21rRNA methylation (GO:0031167)4.19660675
22nuclear pore organization (GO:0006999)4.17128211
23mitotic chromosome condensation (GO:0007076)4.12184078
24rRNA modification (GO:0000154)4.01781189
25purine nucleotide salvage (GO:0032261)3.99689623
26pteridine-containing compound metabolic process (GO:0042558)3.96310161
27ribonucleoprotein complex biogenesis (GO:0022613)3.89288851
28chromosome condensation (GO:0030261)3.80240266
29formation of translation preinitiation complex (GO:0001731)3.76766136
30alternative mRNA splicing, via spliceosome (GO:0000380)3.70505809
31purine nucleobase biosynthetic process (GO:0009113)3.68664783
32DNA replication initiation (GO:0006270)3.62531033
33ribosome assembly (GO:0042255)3.56127233
34pore complex assembly (GO:0046931)3.51381885
35cellular protein complex localization (GO:0034629)3.50843582
36DNA strand elongation involved in DNA replication (GO:0006271)3.46422344
37response to vitamin A (GO:0033189)3.45778518
38negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.45689703
39sulfur amino acid biosynthetic process (GO:0000097)3.42435108
40DNA strand elongation (GO:0022616)3.36957607
41COPI coating of Golgi vesicle (GO:0048205)3.35708947
42Golgi transport vesicle coating (GO:0048200)3.35708947
43transcription from mitochondrial promoter (GO:0006390)3.34741454
44DNA unwinding involved in DNA replication (GO:0006268)3.34164824
45COPII vesicle coating (GO:0048208)3.32961660
46protoporphyrinogen IX metabolic process (GO:0046501)3.31985125
47galactose catabolic process (GO:0019388)3.31452116
48nucleobase biosynthetic process (GO:0046112)3.28193973
49alpha-amino acid biosynthetic process (GO:1901607)3.28040654
50DNA packaging (GO:0006323)3.24385344
51microtubule nucleation (GO:0007020)3.23259311
52CENP-A containing nucleosome assembly (GO:0034080)3.22758179
53mitotic sister chromatid segregation (GO:0000070)3.22075874
54DNA replication checkpoint (GO:0000076)3.19734388
55mitotic nuclear envelope disassembly (GO:0007077)3.18711162
56proline biosynthetic process (GO:0006561)3.18576750
57pseudouridine synthesis (GO:0001522)3.13580854
58protein complex localization (GO:0031503)3.08734011
59tRNA modification (GO:0006400)3.08220500
60cellular component biogenesis (GO:0044085)3.05798951
61ribosomal large subunit biogenesis (GO:0042273)3.00869001
62midgut development (GO:0007494)3.00459007
63negative regulation of DNA biosynthetic process (GO:2000279)3.00368122
64tRNA aminoacylation for protein translation (GO:0006418)2.98288024
65polyamine biosynthetic process (GO:0006596)2.92873838
66sister chromatid segregation (GO:0000819)2.92294521
67nuclear envelope disassembly (GO:0051081)2.91646696
68membrane disassembly (GO:0030397)2.91646696
69regulation of retinoic acid receptor signaling pathway (GO:0048385)2.90910484
70mitochondrial DNA metabolic process (GO:0032042)2.90556107
71telomere maintenance via semi-conservative replication (GO:0032201)2.90215731
72viral mRNA export from host cell nucleus (GO:0046784)2.89776412
73regulation of gonadotropin secretion (GO:0032276)2.89615523
74protoporphyrinogen IX biosynthetic process (GO:0006782)2.88717096
75regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.85090286
76ribosomal small subunit biogenesis (GO:0042274)2.85014354
77DNA replication-independent nucleosome assembly (GO:0006336)2.84675669
78DNA replication-independent nucleosome organization (GO:0034724)2.84675669
79nucleobase-containing small molecule interconversion (GO:0015949)2.84556829
80proteasome assembly (GO:0043248)2.84049596
81tRNA aminoacylation (GO:0043039)2.83738845
82amino acid activation (GO:0043038)2.83738845
83galactose metabolic process (GO:0006012)2.82033656
84chromatin remodeling at centromere (GO:0031055)2.81970031
85protein export from nucleus (GO:0006611)2.79822621
86oxidative phosphorylation (GO:0006119)2.74722156
87response to thyroid hormone (GO:0097066)2.74182694
88peptidyl-proline hydroxylation (GO:0019511)2.72410566
89regulation of translational elongation (GO:0006448)2.72037951
90protein localization to chromosome, centromeric region (GO:0071459)2.71039503
91rRNA processing (GO:0006364)2.70925719
92regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.70610534
93negative regulation of catenin import into nucleus (GO:0035414)2.70524320
94sulfur amino acid metabolic process (GO:0000096)2.69081082
95adenosine metabolic process (GO:0046085)2.68961160
96white fat cell differentiation (GO:0050872)2.68951005
97urea cycle (GO:0000050)2.67956048
98protein-cofactor linkage (GO:0018065)2.63200298
99ribosomal small subunit assembly (GO:0000028)2.62519225
100regulation of RNA export from nucleus (GO:0046831)2.57953373

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.24013789
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.52423693
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.66027644
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.57370267
5ZNF263_19887448_ChIP-Seq_K562_Human3.37670859
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.29389012
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.12417599
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80639125
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.77323750
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.77087312
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76847353
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73443359
13AR_21909140_ChIP-Seq_LNCAP_Human2.66920586
14XRN2_22483619_ChIP-Seq_HELA_Human2.54916724
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53896582
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.53864870
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.45862801
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.38780531
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.34694265
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20155376
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06575053
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.02823356
23DCP1A_22483619_ChIP-Seq_HELA_Human2.02354204
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.98330523
25THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94233022
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93334321
27GABP_19822575_ChIP-Seq_HepG2_Human1.90142543
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.89299478
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.89252172
30DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.83725595
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78554533
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78158971
33TTF2_22483619_ChIP-Seq_HELA_Human1.76590913
34ZFX_18555785_ChIP-Seq_MESCs_Mouse1.76341552
35NCOR1_26117541_ChIP-Seq_K562_Human1.68153231
36PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.66227255
37KDM5A_27292631_Chip-Seq_BREAST_Human1.63269935
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63195093
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.62872667
40CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.59074802
41KLF4_18555785_ChIP-Seq_MESCs_Mouse1.57560532
42CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55725792
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51288561
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51077979
45MYC_22102868_ChIP-Seq_BL_Human1.50005668
46FOXP3_21729870_ChIP-Seq_TREG_Human1.48155571
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47028424
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43734939
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43074946
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42270793
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.41384967
52CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.41062049
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41043573
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40301099
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39514535
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38667459
57TFEB_21752829_ChIP-Seq_HELA_Human1.36925536
58BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.35196212
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34992962
60ELK1_19687146_ChIP-ChIP_HELA_Human1.32973717
61TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30066782
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28602258
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28455815
64CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.28390483
65SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.28096894
66TBX5_21415370_ChIP-Seq_HL-1_Mouse1.26194772
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.25810384
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24389133
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23906462
70VDR_23849224_ChIP-Seq_CD4+_Human1.23417586
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21979175
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20986247
73CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16909882
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12312512
75ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.12218384
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11481908
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10382307
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09454113
79CIITA_25753668_ChIP-Seq_RAJI_Human1.08710861
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04821879
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03461053
82ATF3_27146783_Chip-Seq_COLON_Human1.03271643
83TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02403178
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02388203
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01497411
86CHD1_26751641_Chip-Seq_LNCaP_Human0.98108305
87YY1_21170310_ChIP-Seq_MESCs_Mouse0.96966072
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95182133
89RACK7_27058665_Chip-Seq_MCF-7_Human0.95061861
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94518251
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91599115
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89357428
93GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.86795147
94SOX17_20123909_ChIP-Seq_XEN_Mouse0.86079175
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85614159
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84789722
97GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84252558
98ELK3_25401928_ChIP-Seq_HUVEC_Human0.83309592
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82840681
100LXR_22292898_ChIP-Seq_THP-1_Human0.82452292

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence4.24442199
2MP0003705_abnormal_hypodermis_morpholog4.14432736
3MP0003111_abnormal_nucleus_morphology3.40266146
4MP0004147_increased_porphyrin_level3.33518365
5MP0001661_extended_life_span3.32711220
6MP0004957_abnormal_blastocyst_morpholog3.04351568
7MP0010094_abnormal_chromosome_stability2.99056524
8MP0005360_urolithiasis2.96243658
9MP0003786_premature_aging2.80958089
10MP0003693_abnormal_embryo_hatching2.71474042
11MP0005171_absent_coat_pigmentation2.70450745
12MP0008058_abnormal_DNA_repair2.65849339
13MP0004233_abnormal_muscle_weight2.58670412
14MP0005451_abnormal_body_composition2.43226261
15MP0003077_abnormal_cell_cycle2.42942612
16MP0005670_abnormal_white_adipose2.41704980
17MP0009697_abnormal_copulation2.40784725
18MP0004185_abnormal_adipocyte_glucose2.31819322
19MP0003806_abnormal_nucleotide_metabolis2.30134850
20MP0003186_abnormal_redox_activity2.26691734
21MP0000013_abnormal_adipose_tissue2.17848902
22MP0002877_abnormal_melanocyte_morpholog2.17483763
23MP0002396_abnormal_hematopoietic_system2.12933668
24MP0008932_abnormal_embryonic_tissue2.08416412
25MP0002938_white_spotting2.05663927
26MP0005646_abnormal_pituitary_gland1.95335455
27MP0005408_hypopigmentation1.87483151
28MP0000678_abnormal_parathyroid_gland1.71183769
29MP0000003_abnormal_adipose_tissue1.70469990
30MP0002132_abnormal_respiratory_system1.64366956
31MP0008007_abnormal_cellular_replicative1.57580248
32MP0010234_abnormal_vibrissa_follicle1.51639811
33MP0001730_embryonic_growth_arrest1.46638512
34MP0005076_abnormal_cell_differentiation1.37156359
35MP0001764_abnormal_homeostasis1.36539416
36MP0005332_abnormal_amino_acid1.33703090
37MP0004858_abnormal_nervous_system1.32792047
38MP0000350_abnormal_cell_proliferation1.28219856
39MP0002095_abnormal_skin_pigmentation1.24309861
40MP0008057_abnormal_DNA_replication1.23831936
41MP0002080_prenatal_lethality1.20899031
42MP0001697_abnormal_embryo_size1.19880745
43MP0001348_abnormal_lacrimal_gland1.17544390
44MP0000747_muscle_weakness1.16439048
45MP0003718_maternal_effect1.16050768
46MP0001672_abnormal_embryogenesis/_devel1.15307470
47MP0005380_embryogenesis_phenotype1.15307470
48MP0002269_muscular_atrophy1.12457066
49MP0003984_embryonic_growth_retardation1.10059591
50MP0006035_abnormal_mitochondrial_morpho1.09452190
51MP0006036_abnormal_mitochondrial_physio1.09288344
52MP0000358_abnormal_cell_content/1.08263764
53MP0002210_abnormal_sex_determination1.07991192
54MP0002088_abnormal_embryonic_growth/wei1.07294291
55MP0000372_irregular_coat_pigmentation1.06756296
56MP0000313_abnormal_cell_death1.04378963
57MP0005083_abnormal_biliary_tract1.04311014
58MP0003656_abnormal_erythrocyte_physiolo1.03976280
59MP0002086_abnormal_extraembryonic_tissu1.01273620
60MP0005058_abnormal_lysosome_morphology1.00443672
61MP0000371_diluted_coat_color1.00024215
62MP0010307_abnormal_tumor_latency0.96469890
63MP0003942_abnormal_urinary_system0.95235478
64MP0002009_preneoplasia0.93082528
65MP0001929_abnormal_gametogenesis0.86984909
66MP0002075_abnormal_coat/hair_pigmentati0.86423052
67MP0001145_abnormal_male_reproductive0.86316607
68MP0000647_abnormal_sebaceous_gland0.85377215
69MP0001186_pigmentation_phenotype0.83126156
70MP0008775_abnormal_heart_ventricle0.81196467
71MP0003183_abnormal_peptide_metabolism0.80867364
72MP0005666_abnormal_adipose_tissue0.78850575
73MP0000653_abnormal_sex_gland0.78185828
74MP0005647_abnormal_sex_gland0.77325528
75MP0003123_paternal_imprinting0.75986010
76MP0002160_abnormal_reproductive_system0.74133844
77MP0005636_abnormal_mineral_homeostasis0.70901363
78MP0003959_abnormal_lean_body0.69331828
79MP0000534_abnormal_ureter_morphology0.69046742
80MP0004808_abnormal_hematopoietic_stem0.68521428
81MP0002084_abnormal_developmental_patter0.68232824
82MP0003698_abnormal_male_reproductive0.67701129
83MP0009672_abnormal_birth_weight0.66765742
84MP0000627_abnormal_mammary_gland0.66225974
85MP0003699_abnormal_female_reproductive0.66073104
86MP0000750_abnormal_muscle_regeneration0.65690500
87MP0008438_abnormal_cutaneous_collagen0.65438763
88MP0005375_adipose_tissue_phenotype0.64483704
89MP0002019_abnormal_tumor_incidence0.64453298
90MP0002060_abnormal_skin_morphology0.64360586
91MP0002161_abnormal_fertility/fecundity0.63981219
92MP0002085_abnormal_embryonic_tissue0.63350523
93MP0000598_abnormal_liver_morphology0.62952742
94MP0001502_abnormal_circadian_rhythm0.61715463
95MP0002970_abnormal_white_adipose0.58914933
96MP0009643_abnormal_urine_homeostasis0.57506321
97MP0005319_abnormal_enzyme/_coenzyme0.57353489
98MP0005410_abnormal_fertilization0.57119030
99MP0000609_abnormal_liver_physiology0.56843100
100MP0000759_abnormal_skeletal_muscle0.56554611

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)6.68514261
2Hyperalaninemia (HP:0003348)6.68514261
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)6.68514261
4White forelock (HP:0002211)4.89344097
5Birth length less than 3rd percentile (HP:0003561)4.71204259
6Patchy hypopigmentation of hair (HP:0011365)4.63417168
7Homocystinuria (HP:0002156)4.41482831
8Abnormality of homocysteine metabolism (HP:0010919)4.41482831
9Abnormality of the fetal cardiovascular system (HP:0010948)3.96874053
10Abnormal umbilical cord blood vessels (HP:0011403)3.96874053
11Single umbilical artery (HP:0001195)3.96874053
12Abnormality of glycolysis (HP:0004366)3.86359258
13Cholecystitis (HP:0001082)3.76699118
14Abnormal gallbladder physiology (HP:0012438)3.76699118
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.65627332
16Increased serum pyruvate (HP:0003542)3.58631455
17Abnormality of the umbilical cord (HP:0010881)3.31806529
18Chromsome breakage (HP:0040012)3.30941072
19Abnormality of sulfur amino acid metabolism (HP:0004339)3.25119763
20Ileus (HP:0002595)3.24192310
21Constricted visual fields (HP:0001133)3.14599372
22Fatigue (HP:0012378)3.12401531
23Abnormality of the tricuspid valve (HP:0001702)3.06759563
24Esophageal varix (HP:0002040)3.06036519
25Myocardial infarction (HP:0001658)2.90298916
26Biconcave vertebral bodies (HP:0004586)2.88032851
27Abnormality of serum amino acid levels (HP:0003112)2.81888513
28Reticulocytosis (HP:0001923)2.74100966
29Decreased subcutaneous fat (HP:0001002)2.72018006
30Abnormality of reticulocytes (HP:0004312)2.70397324
31Hypoparathyroidism (HP:0000829)2.67004422
32Hyperthyroidism (HP:0000836)2.66627033
33Hypertensive crisis (HP:0100735)2.66385651
34Congenital sensorineural hearing impairment (HP:0008527)2.63212167
35Reticulocytopenia (HP:0001896)2.62578524
36Abnormality of cochlea (HP:0000375)2.61175383
37Reduced subcutaneous adipose tissue (HP:0003758)2.59967670
38Pallor (HP:0000980)2.52450460
39Truncus arteriosus (HP:0001660)2.50486111
40Progressive muscle weakness (HP:0003323)2.45951077
41Hypopigmentation of the fundus (HP:0007894)2.41583096
42Myopathic facies (HP:0002058)2.40857855
43Morphological abnormality of the inner ear (HP:0011390)2.40169366
44Abnormality of subcutaneous fat tissue (HP:0001001)2.37506022
45Cortical visual impairment (HP:0100704)2.31622763
46Abnormalities of placenta or umbilical cord (HP:0001194)2.31479314
47Sparse lateral eyebrow (HP:0005338)2.29875307
48Bowel incontinence (HP:0002607)2.27600775
49Premature graying of hair (HP:0002216)2.22461896
50Cutaneous melanoma (HP:0012056)2.21892597
51Cholelithiasis (HP:0001081)2.20785449
52Arteriovenous malformation (HP:0100026)2.20231779
53Abnormal large intestine physiology (HP:0012700)2.18680014
54Duplicated collecting system (HP:0000081)2.17553265
55Spontaneous hematomas (HP:0007420)2.17140604
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.16087585
57Insomnia (HP:0100785)2.14066556
58Breast hypoplasia (HP:0003187)2.13941844
59Premature ovarian failure (HP:0008209)2.12482463
60Disproportionate tall stature (HP:0001519)2.11228053
61Abnormality of the heme biosynthetic pathway (HP:0010472)2.09358503
62Anorexia (HP:0002039)2.06556035
63Spastic paraparesis (HP:0002313)2.05554862
64Hyperammonemia (HP:0001987)2.05477690
65Abnormality of pyrimidine metabolism (HP:0004353)2.05470084
66Generalized aminoaciduria (HP:0002909)2.05275799
67Abnormality of DNA repair (HP:0003254)2.05054590
68Progressive external ophthalmoplegia (HP:0000590)2.04525035
69Ureteral duplication (HP:0000073)2.02588109
70Heterochromia iridis (HP:0001100)1.97627177
71Increased serum lactate (HP:0002151)1.96929130
72Conjugated hyperbilirubinemia (HP:0002908)1.96200218
73Abnormality of methionine metabolism (HP:0010901)1.92420100
74Aplasia/Hypoplasia of the sacrum (HP:0008517)1.91963496
75Cerebral hypomyelination (HP:0006808)1.91868498
76Hypoalphalipoproteinemia (HP:0003233)1.90156367
77Abnormality of the renal collecting system (HP:0004742)1.89518269
78Seborrheic dermatitis (HP:0001051)1.89513705
79Hepatocellular carcinoma (HP:0001402)1.88390471
80Abnormality of the carotid arteries (HP:0005344)1.84708394
81Macrocytic anemia (HP:0001972)1.84480333
82Abnormal gallbladder morphology (HP:0012437)1.83678752
83Ankyloglossia (HP:0010296)1.82514232
84Decreased electroretinogram (ERG) amplitude (HP:0000654)1.82073542
85Abnormality of cells of the erythroid lineage (HP:0012130)1.81432200
86Abnormality of the preputium (HP:0100587)1.80780277
87Bone marrow hypocellularity (HP:0005528)1.80049819
88Action tremor (HP:0002345)1.77941735
89Nausea (HP:0002018)1.77481287
90Poor speech (HP:0002465)1.75882395
91Upper limb muscle weakness (HP:0003484)1.75814255
92Esophageal neoplasm (HP:0100751)1.75013491
93Neoplasm of head and neck (HP:0012288)1.75013491
94Megaloblastic anemia (HP:0001889)1.74884307
95Secondary amenorrhea (HP:0000869)1.74501707
96Hypergonadotropic hypogonadism (HP:0000815)1.73774566
97Brittle hair (HP:0002299)1.73679277
98Entropion (HP:0000621)1.73613837
99Abnormality of aromatic amino acid family metabolism (HP:0004338)1.73196139
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.72998762

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.08009724
2PDK23.81043551
3MAP3K33.33110302
4PBK3.04801511
5IRAK32.86141968
6RPS6KB22.79900696
7MAP2K32.73883323
8NME22.59720663
9EEF2K2.58826284
10NEK12.40779212
11BUB12.35073249
12CCNB12.29466694
13TTK2.23508915
14ICK2.21864740
15WEE12.07806676
16PAK41.96423090
17TSSK61.95032520
18MST1R1.90777356
19CDK91.71998267
20BRSK21.68307935
21SCYL21.66645601
22PRKD31.65876016
23TRIB31.53628327
24BRSK11.53578485
25CDC71.51589758
26SRPK11.51457190
27JAK31.48119564
28EIF2AK31.40995230
29CDK121.38687293
30KSR21.37878780
31CDK71.29265997
32CHEK21.28056709
33MAP3K21.25042666
34SMG11.23226480
35AKT31.22609717
36CLK11.18811081
37LATS21.16464003
38NEK21.11321322
39MTOR1.10545556
40NEK61.10289754
41MAP3K81.08893051
42AURKA1.08695861
43NTRK31.06662409
44BMPR21.04747723
45RAF11.03178601
46ATR0.99437599
47MET0.88843375
48ERBB40.88798834
49LMTK20.88367453
50SIK30.87262740
51PTK60.86319780
52KSR10.85989733
53AURKB0.85844349
54WNK40.83835016
55MAP2K10.83300284
56CHEK10.80213663
57SIK10.79274135
58CDK80.75646999
59NME10.74915291
60EPHA20.72051327
61PLK10.69540263
62AKT20.67583218
63PKN20.67238671
64TAOK20.62849460
65CDK20.61566474
66ERN10.60887339
67STK160.59607586
68FGR0.57447792
69STK40.56477922
70CDK10.56454792
71BRAF0.55896023
72TESK20.55656989
73ILK0.55272429
74PRKCI0.54256809
75PAK10.53496173
76PLK30.53496006
77IRAK20.52721460
78PLK40.48904824
79TRIM280.48827218
80ALK0.47972322
81CSNK2A20.47518012
82ACVR1B0.46744897
83PAK20.43039024
84VRK20.42204751
85ATM0.40139033
86CSNK1E0.37582987
87PTK20.35871925
88NTRK10.35375180
89CDK60.34761392
90BRD40.34453984
91MAPKAPK50.34064100
92RPS6KB10.32375320
93ARAF0.31898275
94MST40.31699819
95CSNK2A10.31281171
96STK100.30702363
97CDK40.30316926
98RIPK40.28953497
99BMX0.28203196
100PRPF4B0.27326668

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006704.13834584
2DNA replication_Homo sapiens_hsa030303.12491117
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.05389597
4Arginine biosynthesis_Homo sapiens_hsa002202.91084638
5Biosynthesis of amino acids_Homo sapiens_hsa012302.88558231
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.85715715
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.81504149
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.58300120
9Sulfur relay system_Homo sapiens_hsa041222.40155864
10Mismatch repair_Homo sapiens_hsa034302.37208442
11Spliceosome_Homo sapiens_hsa030402.22478866
12RNA transport_Homo sapiens_hsa030132.15910657
13Cysteine and methionine metabolism_Homo sapiens_hsa002702.12791277
14Ribosome_Homo sapiens_hsa030102.02527612
15Nucleotide excision repair_Homo sapiens_hsa034201.94735432
16Selenocompound metabolism_Homo sapiens_hsa004501.90029657
17Carbon metabolism_Homo sapiens_hsa012001.86694484
18Sulfur metabolism_Homo sapiens_hsa009201.82796616
19Proteasome_Homo sapiens_hsa030501.81515366
20mRNA surveillance pathway_Homo sapiens_hsa030151.76537923
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72836074
22Galactose metabolism_Homo sapiens_hsa000521.66108465
23Base excision repair_Homo sapiens_hsa034101.65409165
24Homologous recombination_Homo sapiens_hsa034401.64619291
25Cell cycle_Homo sapiens_hsa041101.56717180
26Pyruvate metabolism_Homo sapiens_hsa006201.51697647
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45595493
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.44880833
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.44312265
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.41204611
31Pentose phosphate pathway_Homo sapiens_hsa000301.38079299
32RNA polymerase_Homo sapiens_hsa030201.34125929
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33976983
34Basal transcription factors_Homo sapiens_hsa030221.33084216
35Fanconi anemia pathway_Homo sapiens_hsa034601.29977676
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28414723
37Pyrimidine metabolism_Homo sapiens_hsa002401.27359147
38Other glycan degradation_Homo sapiens_hsa005111.26630330
39Fructose and mannose metabolism_Homo sapiens_hsa000511.24900451
40Thyroid cancer_Homo sapiens_hsa052161.17517167
41Folate biosynthesis_Homo sapiens_hsa007901.13289315
42Oxidative phosphorylation_Homo sapiens_hsa001901.06223262
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03819420
44Vibrio cholerae infection_Homo sapiens_hsa051101.03391326
45Fatty acid biosynthesis_Homo sapiens_hsa000611.00505651
46Arginine and proline metabolism_Homo sapiens_hsa003300.99456791
47RNA degradation_Homo sapiens_hsa030180.93246499
48Collecting duct acid secretion_Homo sapiens_hsa049660.90636789
49Vitamin B6 metabolism_Homo sapiens_hsa007500.89971937
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88424933
51Non-homologous end-joining_Homo sapiens_hsa034500.86843562
52Purine metabolism_Homo sapiens_hsa002300.82756074
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81743300
54N-Glycan biosynthesis_Homo sapiens_hsa005100.80425846
55Parkinsons disease_Homo sapiens_hsa050120.77174464
56Huntingtons disease_Homo sapiens_hsa050160.73762873
57Phenylalanine metabolism_Homo sapiens_hsa003600.72262136
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71456362
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.70575116
60Glutathione metabolism_Homo sapiens_hsa004800.64970504
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.63990108
62Metabolic pathways_Homo sapiens_hsa011000.62483404
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61982179
64Prion diseases_Homo sapiens_hsa050200.56984928
65Tyrosine metabolism_Homo sapiens_hsa003500.56383011
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55280969
67Vitamin digestion and absorption_Homo sapiens_hsa049770.52430989
68Alzheimers disease_Homo sapiens_hsa050100.49829951
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49628761
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48917928
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48696126
72Chronic myeloid leukemia_Homo sapiens_hsa052200.47601012
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47276618
74Viral carcinogenesis_Homo sapiens_hsa052030.46999273
75Synaptic vesicle cycle_Homo sapiens_hsa047210.41633629
76Fatty acid metabolism_Homo sapiens_hsa012120.40850217
77Oocyte meiosis_Homo sapiens_hsa041140.39680053
78Alcoholism_Homo sapiens_hsa050340.38906947
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.35381993
80Protein export_Homo sapiens_hsa030600.35379839
81Regulation of autophagy_Homo sapiens_hsa041400.34305950
82p53 signaling pathway_Homo sapiens_hsa041150.33534223
83Fatty acid elongation_Homo sapiens_hsa000620.33127447
84Propanoate metabolism_Homo sapiens_hsa006400.32943081
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30441271
86Non-small cell lung cancer_Homo sapiens_hsa052230.27761582
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26658212
88Epstein-Barr virus infection_Homo sapiens_hsa051690.26340802
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26118239
90Bladder cancer_Homo sapiens_hsa052190.25895113
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24032647
92AMPK signaling pathway_Homo sapiens_hsa041520.23725068
93Lysine degradation_Homo sapiens_hsa003100.22634452
94Small cell lung cancer_Homo sapiens_hsa052220.22266079
95mTOR signaling pathway_Homo sapiens_hsa041500.21928378
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21136074
97Acute myeloid leukemia_Homo sapiens_hsa052210.20299842
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19268527
99Steroid biosynthesis_Homo sapiens_hsa001000.19114320
100Pancreatic cancer_Homo sapiens_hsa052120.18385558

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