ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of translational fidelity (GO:0006450)	6.06706898
2	L-serine metabolic process (GO:0006563)	5.00302742
3	COPI coating of Golgi vesicle (GO:0048205)	4.66849588
4	Golgi transport vesicle coating (GO:0048200)	4.66849588
5	ribosome assembly (GO:0042255)	4.55130879
6	folic acid-containing compound biosynthetic process (GO:0009396)	4.53554589
7	formation of translation preinitiation complex (GO:0001731)	4.51101518
8	nuclear pore complex assembly (GO:0051292)	4.46721017
9	proline biosynthetic process (GO:0006561)	4.13777859
10	negative regulation of protein acetylation (GO:1901984)	4.07036303
11	mitotic chromosome condensation (GO:0007076)	4.02563869
12	ribosome biogenesis (GO:0042254)	3.95510587
13	nuclear pore organization (GO:0006999)	3.91870183
14	folic acid-containing compound metabolic process (GO:0006760)	3.90240112
15	IMP biosynthetic process (GO:0006188)	3.88508326
16	DNA unwinding involved in DNA replication (GO:0006268)	3.86236938
17	regulation of translational elongation (GO:0006448)	3.85738379
18	regulation of translational termination (GO:0006449)	3.70762757
19	tRNA aminoacylation for protein translation (GO:0006418)	3.69777228
20	homocysteine metabolic process (GO:0050667)	3.66815391
21	serine family amino acid biosynthetic process (GO:0009070)	3.58978725
22	biotin metabolic process (GO:0006768)	3.57214434
23	tRNA aminoacylation (GO:0043039)	3.54917296
24	amino acid activation (GO:0043038)	3.54917296
25	pteridine-containing compound biosynthetic process (GO:0042559)	3.52605230
26	nucleobase-containing small molecule interconversion (GO:0015949)	3.48377702
27	ribonucleoprotein complex biogenesis (GO:0022613)	3.47361017
28	DNA replication initiation (GO:0006270)	3.40407668
29	rRNA methylation (GO:0031167)	3.39101237
30	pteridine-containing compound metabolic process (GO:0042558)	3.38807267
31	IMP metabolic process (GO:0046040)	3.38568920
32	purine nucleobase biosynthetic process (GO:0009113)	3.34261419
33	rRNA modification (GO:0000154)	3.29523921
34	DNA strand elongation involved in DNA replication (GO:0006271)	3.29288517
35	mitotic nuclear envelope disassembly (GO:0007077)	3.29246920
36	iron ion import (GO:0097286)	3.25391577
37	mitochondrial RNA metabolic process (GO:0000959)	3.23021855
38	transcription from mitochondrial promoter (GO:0006390)	3.22749405
39	protoporphyrinogen IX metabolic process (GO:0046501)	3.21925888
40	DNA strand elongation (GO:0022616)	3.19512139
41	nucleobase biosynthetic process (GO:0046112)	3.19264360
42	protein complex localization (GO:0031503)	3.18037594
43	folic acid metabolic process (GO:0046655)	3.17377369
44	pore complex assembly (GO:0046931)	3.16121070
45	mitotic sister chromatid segregation (GO:0000070)	3.16012091
46	tetrahydrofolate metabolic process (GO:0046653)	3.15874147
47	mRNA cleavage (GO:0006379)	3.11277883
48	mitochondrial DNA metabolic process (GO:0032042)	3.10920574
49	membrane disassembly (GO:0030397)	3.08861143
50	nuclear envelope disassembly (GO:0051081)	3.08861143
51	ncRNA 3-end processing (GO:0043628)	3.06540813
52	cellular protein complex localization (GO:0034629)	3.06094175
53	ribosomal large subunit biogenesis (GO:0042273)	3.04788015
54	protein localization to microtubule (GO:0035372)	2.98188859
55	maturation of SSU-rRNA (GO:0030490)	2.97228318
56	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.94961770
57	telomere maintenance via semi-conservative replication (GO:0032201)	2.94242745
58	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	2.92689349
59	ribosomal small subunit biogenesis (GO:0042274)	2.91361788
60	chromosome condensation (GO:0030261)	2.84731151
61	nuclear envelope organization (GO:0006998)	2.83822026
62	mitotic metaphase plate congression (GO:0007080)	2.83517769
63	protein export from nucleus (GO:0006611)	2.81227572
64	sister chromatid segregation (GO:0000819)	2.80823309
65	ribosomal small subunit assembly (GO:0000028)	2.80461984
66	regulation of protein sumoylation (GO:0033233)	2.79371152
67	nuclear envelope reassembly (GO:0031468)	2.75321012
68	mitotic nuclear envelope reassembly (GO:0007084)	2.75321012
69	NADH metabolic process (GO:0006734)	2.73517676
70	proteasome assembly (GO:0043248)	2.73116610
71	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.72291274
72	alpha-amino acid biosynthetic process (GO:1901607)	2.68373762
73	proline metabolic process (GO:0006560)	2.68027912
74	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	2.67000805
75	maturation of 5.8S rRNA (GO:0000460)	2.66012228
76	terpenoid biosynthetic process (GO:0016114)	2.64667501
77	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.63697924
78	gonadal mesoderm development (GO:0007506)	2.63516248
79	rRNA processing (GO:0006364)	2.63466865
80	positive regulation of DNA-dependent DNA replication (GO:2000105)	2.63397486
81	chaperone-mediated protein complex assembly (GO:0051131)	2.63148892
82	sulfur amino acid biosynthetic process (GO:0000097)	2.62355116
83	DNA packaging (GO:0006323)	2.61542149
84	negative regulation of mRNA metabolic process (GO:1903312)	2.59494060
85	viral mRNA export from host cell nucleus (GO:0046784)	2.58969329
86	desmosome organization (GO:0002934)	2.57987969
87	cysteine metabolic process (GO:0006534)	2.57575138
88	establishment of integrated proviral latency (GO:0075713)	2.57392325
89	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.57205027
90	protein localization to chromosome, centromeric region (GO:0071459)	2.57146861
91	snRNA metabolic process (GO:0016073)	2.56693488
92	oxidative phosphorylation (GO:0006119)	2.56205425
93	DNA replication checkpoint (GO:0000076)	2.53658477
94	regulation of plasminogen activation (GO:0010755)	2.53200182
95	mitotic sister chromatid cohesion (GO:0007064)	2.53109064
96	mRNA polyadenylation (GO:0006378)	2.52727617
97	protein retention in ER lumen (GO:0006621)	2.50594163
98	rRNA metabolic process (GO:0016072)	2.49941816
99	negative regulation of mRNA processing (GO:0050686)	2.48899937
100	aspartate family amino acid biosynthetic process (GO:0009067)	2.47993588

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.83533762
2	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.91714204
3	AR_21909140_ChIP-Seq_LNCAP_Human	3.71727570
4	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.69014693
5	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.02259242
6	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.91361450
7	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.78377098
8	ZNF263_19887448_ChIP-Seq_K562_Human	2.76360971
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.69864957
10	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.68429435
11	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.68101614
12	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.60265483
13	XRN2_22483619_ChIP-Seq_HELA_Human	2.54730234
14	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.50586526
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.49034805
16	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.42306016
17	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.34053426
18	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.33889244
19	DCP1A_22483619_ChIP-Seq_HELA_Human	2.27676335
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.23234742
21	MYCN_18555785_ChIP-Seq_MESCs_Mouse	2.20506190
22	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.19968973
23	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.10738242
24	ZFX_18555785_ChIP-Seq_MESCs_Mouse	2.07632399
25	TTF2_22483619_ChIP-Seq_HELA_Human	1.98594844
26	GABP_19822575_ChIP-Seq_HepG2_Human	1.96977314
27	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.91664158
28	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.91530567
29	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.90141039
30	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.89596838
31	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.86815926
32	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.81923190
33	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.76220831
34	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.74853107
35	KDM5A_27292631_Chip-Seq_BREAST_Human	1.74315425
36	CHD1_26751641_Chip-Seq_LNCaP_Human	1.71824524
37	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.69068927
38	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.68917349
39	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.67375454
40	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.66986530
41	MYC_22102868_ChIP-Seq_BL_Human	1.65966450
42	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.62698019
43	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.55768072
44	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.55624763
45	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.53025341
46	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.50909001
47	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.49824598
48	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.49717643
49	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.49338731
50	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.48446439
51	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.47388565
52	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.41086574
53	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.39676168
54	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.39170078
55	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.37728240
56	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.37546868
57	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.36723258
58	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.33345275
59	FOXP3_21729870_ChIP-Seq_TREG_Human	1.32612152
60	ATF3_27146783_Chip-Seq_COLON_Human	1.30926804
61	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.28872017
62	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.27439626
63	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.27319013
64	TFEB_21752829_ChIP-Seq_HELA_Human	1.26174409
65	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.25424262
66	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.24477530
67	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.21987925
68	ELK1_19687146_ChIP-ChIP_HELA_Human	1.21709336
69	VDR_23849224_ChIP-Seq_CD4+_Human	1.21600177
70	CIITA_25753668_ChIP-Seq_RAJI_Human	1.20374536
71	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.19879634
72	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.19657098
73	RACK7_27058665_Chip-Seq_MCF-7_Human	1.19458229
74	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.18622708
75	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.18482220
76	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.17883752
77	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.17819419
78	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.15012086
79	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.14187732
80	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.13715115
81	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.12729640
82	NCOR1_26117541_ChIP-Seq_K562_Human	1.12214355
83	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.10195705
84	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.09031236
85	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.08185372
86	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.07033975
87	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.04202046
88	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.03033111
89	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.00790510
90	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.99940787
91	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	0.99848161
92	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.99558350
93	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.99390564
94	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.95789835
95	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.94688981
96	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.93975518
97	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.93228349
98	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.92152169
99	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.90378696
100	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.89956269

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010234_abnormal_vibrissa_follicle	4.39195016
2	MP0004858_abnormal_nervous_system	4.35452653
3	MP0004957_abnormal_blastocyst_morpholog	3.54674997
4	MP0003111_abnormal_nucleus_morphology	3.30007813
5	MP0005451_abnormal_body_composition	3.26391302
6	MP0003705_abnormal_hypodermis_morpholog	3.10972243
7	MP0004233_abnormal_muscle_weight	3.09684049
8	MP0010094_abnormal_chromosome_stability	3.08816272
9	MP0003693_abnormal_embryo_hatching	2.94698805
10	MP0001661_extended_life_span	2.79230266
11	MP0009697_abnormal_copulation	2.70202090
12	MP0003077_abnormal_cell_cycle	2.55435973
13	MP0004185_abnormal_adipocyte_glucose	2.47759468
14	MP0003786_premature_aging	2.37365862
15	MP0008995_early_reproductive_senescence	2.28824051
16	MP0002877_abnormal_melanocyte_morpholog	2.27386081
17	MP0008058_abnormal_DNA_repair	2.22879025
18	MP0000537_abnormal_urethra_morphology	2.21032225
19	MP0005171_absent_coat_pigmentation	2.10040768
20	MP0008932_abnormal_embryonic_tissue	2.07455928
21	MP0003123_paternal_imprinting	2.02970760
22	MP0001730_embryonic_growth_arrest	1.94157965
23	MP0008007_abnormal_cellular_replicative	1.70380247
24	MP0000350_abnormal_cell_proliferation	1.65770532
25	MP0008057_abnormal_DNA_replication	1.65471357
26	MP0005408_hypopigmentation	1.53946295
27	MP0005076_abnormal_cell_differentiation	1.48509941
28	MP0006035_abnormal_mitochondrial_morpho	1.46891723
29	MP0002080_prenatal_lethality	1.46181930
30	MP0005666_abnormal_adipose_tissue	1.43353913
31	MP0005380_embryogenesis_phenotype	1.39923897
32	MP0001672_abnormal_embryogenesis/_devel	1.39923897
33	MP0001348_abnormal_lacrimal_gland	1.38555123
34	MP0005360_urolithiasis	1.38176680
35	MP0005670_abnormal_white_adipose	1.34140337
36	MP0003186_abnormal_redox_activity	1.33879486
37	MP0003718_maternal_effect	1.33842256
38	MP0003984_embryonic_growth_retardation	1.29727645
39	MP0001697_abnormal_embryo_size	1.29087345
40	MP0000358_abnormal_cell_content/	1.26326675
41	MP0005501_abnormal_skin_physiology	1.25346257
42	MP0002009_preneoplasia	1.24830965
43	MP0002088_abnormal_embryonic_growth/wei	1.24514846
44	MP0002086_abnormal_extraembryonic_tissu	1.24248205
45	MP0000747_muscle_weakness	1.18023719
46	MP0000627_abnormal_mammary_gland	1.17307991
47	MP0000678_abnormal_parathyroid_gland	1.16832953
48	MP0003315_abnormal_perineum_morphology	1.16270672
49	MP0004197_abnormal_fetal_growth/weight/	1.09867057
50	MP0006036_abnormal_mitochondrial_physio	1.08835014
51	MP0003656_abnormal_erythrocyte_physiolo	1.08703170
52	MP0003806_abnormal_nucleotide_metabolis	1.08294641
53	MP0005330_cardiomyopathy	1.05682483
54	MP0002084_abnormal_developmental_patter	1.04094931
55	MP0000313_abnormal_cell_death	1.03079005
56	MP0004264_abnormal_extraembryonic_tissu	1.02208657
57	MP0002085_abnormal_embryonic_tissue	1.00952172
58	MP0002796_impaired_skin_barrier	0.99392658
59	MP0001881_abnormal_mammary_gland	0.98817696
60	MP0003941_abnormal_skin_development	0.98358348
61	MP0010352_gastrointestinal_tract_polyps	0.96260091
62	MP0003221_abnormal_cardiomyocyte_apopto	0.93861146
63	MP0000377_abnormal_hair_follicle	0.92560504
64	MP0009672_abnormal_birth_weight	0.89427704
65	MP0002210_abnormal_sex_determination	0.87512135
66	MP0002060_abnormal_skin_morphology	0.86916909
67	MP0000003_abnormal_adipose_tissue	0.85148920
68	MP0005384_cellular_phenotype	0.84825493
69	MP0002938_white_spotting	0.84255138
70	MP0002269_muscular_atrophy	0.83327224
71	MP0000613_abnormal_salivary_gland	0.81382185
72	MP0010307_abnormal_tumor_latency	0.80300423
73	MP0002822_catalepsy	0.78956406
74	MP0001186_pigmentation_phenotype	0.78589412
75	MP0003942_abnormal_urinary_system	0.78111753
76	MP0005621_abnormal_cell_physiology	0.78033866
77	MP0004808_abnormal_hematopoietic_stem	0.77677208
78	MP0005375_adipose_tissue_phenotype	0.77007126
79	MP0001145_abnormal_male_reproductive	0.76193802
80	MP0001216_abnormal_epidermal_layer	0.75279240
81	MP0005187_abnormal_penis_morphology	0.74072274
82	MP0002249_abnormal_larynx_morphology	0.73228937
83	MP0000733_abnormal_muscle_development	0.72382388
84	MP0000647_abnormal_sebaceous_gland	0.70975978
85	MP0002970_abnormal_white_adipose	0.70795207
86	MP0001764_abnormal_homeostasis	0.70707547
87	MP0002160_abnormal_reproductive_system	0.70316592
88	MP0002075_abnormal_coat/hair_pigmentati	0.69902920
89	MP0001919_abnormal_reproductive_system	0.69097811
90	MP0010030_abnormal_orbit_morphology	0.67932562
91	MP0002396_abnormal_hematopoietic_system	0.67071708
92	MP0000534_abnormal_ureter_morphology	0.66708841
93	MP0005647_abnormal_sex_gland	0.66599939
94	MP0008260_abnormal_autophagy	0.65999700
95	MP0005257_abnormal_intraocular_pressure	0.65584017
96	MP0005058_abnormal_lysosome_morphology	0.64939660
97	MP0001849_ear_inflammation	0.64930710
98	MP0004147_increased_porphyrin_level	0.64897021
99	MP0001929_abnormal_gametogenesis	0.64778813
100	MP0009053_abnormal_anal_canal	0.62863963

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Cholecystitis (HP:0001082)	3.70839362
2	Abnormal gallbladder physiology (HP:0012438)	3.70839362
3	Abnormality of glycolysis (HP:0004366)	3.69088234
4	Abnormality of the distal phalanges of the toes (HP:0010182)	3.58936929
5	Sparse lateral eyebrow (HP:0005338)	3.51093742
6	Entropion (HP:0000621)	3.39505183
7	Abnormality of homocysteine metabolism (HP:0010919)	3.31826026
8	Homocystinuria (HP:0002156)	3.31826026
9	Reduced subcutaneous adipose tissue (HP:0003758)	3.20224224
10	Abnormality of the umbilical cord (HP:0010881)	3.11172900
11	Birth length less than 3rd percentile (HP:0003561)	3.08217246
12	Progressive muscle weakness (HP:0003323)	3.00536480
13	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.86194022
14	Testicular atrophy (HP:0000029)	2.84410208
15	Increased serum pyruvate (HP:0003542)	2.83122028
16	Short nail (HP:0001799)	2.82989277
17	Upper limb muscle weakness (HP:0003484)	2.70294171
18	Insomnia (HP:0100785)	2.69266037
19	Spastic paraparesis (HP:0002313)	2.66285785
20	Progressive external ophthalmoplegia (HP:0000590)	2.62093360
21	Cholelithiasis (HP:0001081)	2.60021449
22	Long palpebral fissure (HP:0000637)	2.51951737
23	Chromsome breakage (HP:0040012)	2.45585705
24	Ragged-red muscle fibers (HP:0003200)	2.44546168
25	Rough bone trabeculation (HP:0100670)	2.37753067
26	Trismus (HP:0000211)	2.36965046
27	Reticulocytosis (HP:0001923)	2.36385610
28	Ankyloglossia (HP:0010296)	2.34722015
29	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.32988614
30	Abnormality of alanine metabolism (HP:0010916)	2.32988614
31	Hyperalaninemia (HP:0003348)	2.32988614
32	Glossoptosis (HP:0000162)	2.31849825
33	Multiple enchondromatosis (HP:0005701)	2.31395647
34	Dysmetric saccades (HP:0000641)	2.28902054
35	Premature rupture of membranes (HP:0001788)	2.26744031
36	Abnormal gallbladder morphology (HP:0012437)	2.26116964
37	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.22752732
38	Abnormality of the gallbladder (HP:0005264)	2.22640406
39	Ureteral duplication (HP:0000073)	2.21457879
40	Paraparesis (HP:0002385)	2.20863533
41	Hyperacusis (HP:0010780)	2.20319473
42	Breast hypoplasia (HP:0003187)	2.18751324
43	Abnormality of reticulocytes (HP:0004312)	2.18190416
44	Disproportionate tall stature (HP:0001519)	2.17459307
45	Truncus arteriosus (HP:0001660)	2.16995630
46	Abnormalities of placenta or umbilical cord (HP:0001194)	2.14070045
47	Hyperthyroidism (HP:0000836)	2.12266780
48	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.11137570
49	Advanced eruption of teeth (HP:0006288)	2.08404112
50	Diaphragmatic weakness (HP:0009113)	2.08094528
51	Abnormal trabecular bone morphology (HP:0100671)	2.07276658
52	Submucous cleft hard palate (HP:0000176)	2.04349179
53	Patchy hypopigmentation of hair (HP:0011365)	2.03841111
54	Termporal pattern (HP:0011008)	2.03170137
55	Insidious onset (HP:0003587)	2.03170137
56	Premature ovarian failure (HP:0008209)	1.99039291
57	Unilateral renal agenesis (HP:0000122)	1.95782535
58	Biconcave vertebral bodies (HP:0004586)	1.94703674
59	Cerebral hypomyelination (HP:0006808)	1.94393203
60	Abnormal umbilical cord blood vessels (HP:0011403)	1.93521746
61	Single umbilical artery (HP:0001195)	1.93521746
62	Abnormality of the fetal cardiovascular system (HP:0010948)	1.93521746
63	Abnormality of the preputium (HP:0100587)	1.93114492
64	Fatigue (HP:0012378)	1.92465637
65	Sparse eyelashes (HP:0000653)	1.91381831
66	Bowel incontinence (HP:0002607)	1.89877672
67	Progressive hearing impairment (HP:0001730)	1.89204186
68	Seborrheic dermatitis (HP:0001051)	1.87033343
69	Cortical dysplasia (HP:0002539)	1.84356827
70	Osteolytic defects of the phalanges of the hand (HP:0009771)	1.84206327
71	Osteolytic defects of the hand bones (HP:0009699)	1.84206327
72	Achilles tendon contracture (HP:0001771)	1.83438900
73	Glucose intolerance (HP:0000833)	1.83105971
74	Abnormal large intestine physiology (HP:0012700)	1.82487200
75	White forelock (HP:0002211)	1.82216992
76	Hyperammonemia (HP:0001987)	1.80324148
77	Megaloblastic anemia (HP:0001889)	1.80254811
78	Reticulocytopenia (HP:0001896)	1.79778341
79	Secondary amenorrhea (HP:0000869)	1.79504025
80	Abnormality of fatty-acid metabolism (HP:0004359)	1.79092488
81	Abnormality of subcutaneous fat tissue (HP:0001001)	1.78652514
82	Urethral obstruction (HP:0000796)	1.76710496
83	Cutaneous melanoma (HP:0012056)	1.76671174
84	Vertebral compression fractures (HP:0002953)	1.76409582
85	Microvesicular hepatic steatosis (HP:0001414)	1.74642804
86	Short clavicles (HP:0000894)	1.72140868
87	Hypoparathyroidism (HP:0000829)	1.69869578
88	Pili torti (HP:0003777)	1.69412716
89	Esophageal neoplasm (HP:0100751)	1.69040424
90	Neoplasm of head and neck (HP:0012288)	1.69040424
91	Abnormality of the tricuspid valve (HP:0001702)	1.67570300
92	Premature graying of hair (HP:0002216)	1.67027766
93	Slender long bone (HP:0003100)	1.66381443
94	Postnatal microcephaly (HP:0005484)	1.66114580
95	Increased nuchal translucency (HP:0010880)	1.65754603
96	Brittle hair (HP:0002299)	1.65040861
97	Myopathic facies (HP:0002058)	1.64799866
98	Hypergonadotropic hypogonadism (HP:0000815)	1.63583076
99	Abnormality of oral frenula (HP:0000190)	1.62985252
100	Patellar dislocation (HP:0002999)	1.61090549

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK1	4.32408100
2	PRKD3	3.99568242
3	EEF2K	3.55981521
4	IRAK3	3.00426384
5	ICK	2.78366918
6	SMG1	2.72524643
7	NME2	2.56609623
8	AKT3	2.53033216
9	EPHA2	2.51403466
10	BUB1	2.40467465
11	TSSK6	2.38047405
12	NEK1	2.26721894
13	PBK	2.26127270
14	TRIB3	2.19332971
15	EIF2AK3	2.17685240
16	MST1R	2.16301601
17	MST4	2.12193082
18	CDK12	1.98638389
19	PAK4	1.96156885
20	WEE1	1.93614613
21	SCYL2	1.84908575
22	RPS6KB2	1.68507818
23	TTK	1.53526785
24	SRPK1	1.51625360
25	ERBB4	1.44124296
26	WNK4	1.42752067
27	BRSK1	1.42104146
28	MAP3K3	1.37314020
29	SIK1	1.32964635
30	CDK7	1.30744035
31	LATS2	1.29585773
32	VRK2	1.24773794
33	LMTK2	1.23145026
34	CAMK1D	1.19125919
35	CDC7	1.18472137
36	MET	1.17653681
37	MAP3K8	1.16809941
38	PKN2	1.14880799
39	TAF1	1.12594308
40	BRSK2	1.07096350
41	NEK2	0.98049298
42	CDK9	0.93642582
43	KSR2	0.92873368
44	BRD4	0.89632071
45	CHEK2	0.89044423
46	MTOR	0.87352729
47	MAP3K2	0.86526964
48	TAOK2	0.85212652
49	CDK8	0.84137078
50	MAPKAPK3	0.81265681
51	AKT2	0.81258317
52	NME1	0.80740955
53	MAP2K3	0.78888254
54	BRAF	0.76596802
55	ARAF	0.76081678
56	DYRK3	0.75753925
57	STK16	0.75331324
58	AURKA	0.75322700
59	PTK6	0.74510381
60	RAF1	0.73616184
61	STK39	0.70416989
62	CHEK1	0.69770411
63	EIF2AK2	0.69117111
64	CCNB1	0.68674821
65	CAMK1G	0.64783217
66	PRKD2	0.64143521
67	ATR	0.63396328
68	SIK3	0.62177022
69	LRRK2	0.61803002
70	PTK2	0.60537127
71	NTRK1	0.58194183
72	ILK	0.56852756
73	PNCK	0.54337694
74	AURKB	0.53569400
75	CDK6	0.52042675
76	KSR1	0.52037805
77	MAP3K9	0.52019010
78	PLK3	0.50747089
79	STK10	0.50205716
80	FLT3	0.49998869
81	IRAK2	0.49927578
82	PRKCI	0.48879458
83	PAK2	0.47749947
84	PLK1	0.46834792
85	PASK	0.44828828
86	FER	0.43687422
87	ALK	0.43444289
88	PDGFRA	0.40945814
89	CDK1	0.40728483
90	PIM2	0.40497727
91	CDK2	0.39446104
92	CSNK2A2	0.37844652
93	CSNK1E	0.35539862
94	ATM	0.32820799
95	WNK1	0.31667239
96	TRIM28	0.28785582
97	STK4	0.27951908
98	CDK4	0.27612057
99	ERN1	0.26702519
100	BMPR2	0.26298419

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.83632793
2	DNA replication_Homo sapiens_hsa03030	2.91288963
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.85464273
4	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.80288051
5	One carbon pool by folate_Homo sapiens_hsa00670	2.73898369
6	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.66271985
7	Biosynthesis of amino acids_Homo sapiens_hsa01230	2.65495496
8	RNA transport_Homo sapiens_hsa03013	2.34412578
9	Spliceosome_Homo sapiens_hsa03040	2.17588137
10	Proteasome_Homo sapiens_hsa03050	2.15408915
11	Mismatch repair_Homo sapiens_hsa03430	2.13792940
12	Nucleotide excision repair_Homo sapiens_hsa03420	2.07869449
13	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.94868322
14	mRNA surveillance pathway_Homo sapiens_hsa03015	1.86482204
15	Carbon metabolism_Homo sapiens_hsa01200	1.86409907
16	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.86105510
17	Base excision repair_Homo sapiens_hsa03410	1.81944369
18	Ribosome_Homo sapiens_hsa03010	1.76913548
19	Pyruvate metabolism_Homo sapiens_hsa00620	1.75831224
20	Pentose phosphate pathway_Homo sapiens_hsa00030	1.62798641
21	Cell cycle_Homo sapiens_hsa04110	1.62631863
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.60425132
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.60338917
24	RNA polymerase_Homo sapiens_hsa03020	1.59184204
25	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.56892256
26	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.56524980
27	Basal transcription factors_Homo sapiens_hsa03022	1.54433772
28	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.48255966
29	Arginine and proline metabolism_Homo sapiens_hsa00330	1.47155259
30	Sulfur relay system_Homo sapiens_hsa04122	1.46870054
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.44667600
32	Thyroid cancer_Homo sapiens_hsa05216	1.40619828
33	Phenylalanine metabolism_Homo sapiens_hsa00360	1.34703573
34	Arginine biosynthesis_Homo sapiens_hsa00220	1.29380260
35	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.23594874
36	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.23075108
37	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.18872376
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.17885265
39	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.17365558
40	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.17256150
41	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.08362827
42	Non-homologous end-joining_Homo sapiens_hsa03450	1.07759278
43	RNA degradation_Homo sapiens_hsa03018	1.05473198
44	Homologous recombination_Homo sapiens_hsa03440	1.04949987
45	Fanconi anemia pathway_Homo sapiens_hsa03460	0.97810331
46	Sulfur metabolism_Homo sapiens_hsa00920	0.96243807
47	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.93135777
48	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.89596484
49	Protein export_Homo sapiens_hsa03060	0.87350281
50	Prion diseases_Homo sapiens_hsa05020	0.85910322
51	Folate biosynthesis_Homo sapiens_hsa00790	0.84929808
52	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.81498400
53	Glutathione metabolism_Homo sapiens_hsa00480	0.79964496
54	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.75168892
55	Vibrio cholerae infection_Homo sapiens_hsa05110	0.74729485
56	p53 signaling pathway_Homo sapiens_hsa04115	0.74273459
57	Galactose metabolism_Homo sapiens_hsa00052	0.74221829
58	Lysine degradation_Homo sapiens_hsa00310	0.72900867
59	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.72894819
60	Prostate cancer_Homo sapiens_hsa05215	0.71090835
61	Purine metabolism_Homo sapiens_hsa00230	0.70667690
62	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.69053121
63	Bladder cancer_Homo sapiens_hsa05219	0.65716642
64	Fatty acid metabolism_Homo sapiens_hsa01212	0.64870145
65	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.63332276
66	Oocyte meiosis_Homo sapiens_hsa04114	0.62797625
67	Tyrosine metabolism_Homo sapiens_hsa00350	0.60020260
68	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.58954658
69	Insulin signaling pathway_Homo sapiens_hsa04910	0.57424953
70	mTOR signaling pathway_Homo sapiens_hsa04150	0.54899965
71	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.51069393
72	Endometrial cancer_Homo sapiens_hsa05213	0.49620662
73	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.48586275
74	AMPK signaling pathway_Homo sapiens_hsa04152	0.48468248
75	Metabolic pathways_Homo sapiens_hsa01100	0.47571099
76	Fatty acid elongation_Homo sapiens_hsa00062	0.44704940
77	Non-small cell lung cancer_Homo sapiens_hsa05223	0.44142889
78	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.43917231
79	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.43907601
80	Huntingtons disease_Homo sapiens_hsa05016	0.41998037
81	ErbB signaling pathway_Homo sapiens_hsa04012	0.41660281
82	Propanoate metabolism_Homo sapiens_hsa00640	0.39830273
83	Small cell lung cancer_Homo sapiens_hsa05222	0.39027282
84	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.37687652
85	MicroRNAs in cancer_Homo sapiens_hsa05206	0.37656487
86	Viral carcinogenesis_Homo sapiens_hsa05203	0.37136809
87	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.34977171
88	Adherens junction_Homo sapiens_hsa04520	0.34767542
89	Parkinsons disease_Homo sapiens_hsa05012	0.33601710
90	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.33206340
91	Pancreatic cancer_Homo sapiens_hsa05212	0.33108030
92	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.29889276
93	Renal cell carcinoma_Homo sapiens_hsa05211	0.27425112
94	Glioma_Homo sapiens_hsa05214	0.27186926
95	Steroid biosynthesis_Homo sapiens_hsa00100	0.27043538
96	beta-Alanine metabolism_Homo sapiens_hsa00410	0.25310088
97	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.24677896
98	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.24315159
99	VEGF signaling pathway_Homo sapiens_hsa04370	0.23330804
100	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.20638275

MAGEA2B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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