MAGEA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)7.25556197
2gonadal mesoderm development (GO:0007506)6.86377400
3peptidyl-tyrosine autophosphorylation (GO:0038083)6.03681329
4nuclear pore complex assembly (GO:0051292)5.85967087
5DNA methylation involved in gamete generation (GO:0043046)5.85949754
6regulation of translational fidelity (GO:0006450)5.82087678
7positive regulation of dendritic spine morphogenesis (GO:0061003)5.75751849
8kinetochore organization (GO:0051383)5.08146531
9nuclear pore organization (GO:0006999)5.00924543
10synaptonemal complex assembly (GO:0007130)4.86321779
11ribosomal small subunit biogenesis (GO:0042274)4.82936371
12male sex determination (GO:0030238)4.81687538
13formation of translation preinitiation complex (GO:0001731)4.76747253
14kinetochore assembly (GO:0051382)4.68934472
15Golgi transport vesicle coating (GO:0048200)4.65600853
16COPI coating of Golgi vesicle (GO:0048205)4.65600853
17positive regulation of vascular permeability (GO:0043117)4.65141579
18embryonic foregut morphogenesis (GO:0048617)4.49772780
19proline biosynthetic process (GO:0006561)4.45708136
20axon ensheathment in central nervous system (GO:0032291)4.40452203
21central nervous system myelination (GO:0022010)4.40452203
22pore complex assembly (GO:0046931)4.37298565
23paraxial mesoderm development (GO:0048339)4.31718656
24DNA unwinding involved in DNA replication (GO:0006268)4.22577479
25synaptonemal complex organization (GO:0070193)4.21035794
26glomerular filtration (GO:0003094)4.20557946
27maturation of SSU-rRNA (GO:0030490)4.17447718
28meiotic chromosome segregation (GO:0045132)4.17009847
29ribosome assembly (GO:0042255)4.16546826
30attachment of spindle microtubules to kinetochore (GO:0008608)4.09029500
31nucleobase-containing small molecule interconversion (GO:0015949)4.02793653
32ribosomal large subunit biogenesis (GO:0042273)4.00101428
33mitotic sister chromatid segregation (GO:0000070)3.96343658
34sister chromatid segregation (GO:0000819)3.95453949
35ribonucleoprotein complex biogenesis (GO:0022613)3.92661864
36ribosome biogenesis (GO:0042254)3.92055394
37mitotic nuclear envelope disassembly (GO:0007077)3.89255732
38DNA strand elongation involved in DNA replication (GO:0006271)3.87417563
39chromosome organization involved in meiosis (GO:0070192)3.86614391
40endothelium development (GO:0003158)3.80788738
41regulation of meiosis I (GO:0060631)3.78387156
42DNA strand elongation (GO:0022616)3.77004978
43meiotic nuclear division (GO:0007126)3.73986875
44renal filtration (GO:0097205)3.72692075
45DNA replication initiation (GO:0006270)3.70175158
46limb bud formation (GO:0060174)3.67470776
47tRNA aminoacylation for protein translation (GO:0006418)3.67373447
48left/right axis specification (GO:0070986)3.65955016
49positive regulation of meiosis (GO:0045836)3.64752857
50DNA topological change (GO:0006265)3.61834009
51homocysteine metabolic process (GO:0050667)3.60932700
52nuclear envelope disassembly (GO:0051081)3.60757154
53membrane disassembly (GO:0030397)3.60757154
54cellular response to cholesterol (GO:0071397)3.59494168
55DNA replication checkpoint (GO:0000076)3.55473661
56telomere maintenance via semi-conservative replication (GO:0032201)3.55343524
57regulation of translational elongation (GO:0006448)3.54696140
58amino acid activation (GO:0043038)3.53861772
59tRNA aminoacylation (GO:0043039)3.53861772
60protein localization to kinetochore (GO:0034501)3.53493561
61viral transcription (GO:0019083)3.52558357
62spinal cord motor neuron differentiation (GO:0021522)3.52492596
63folic acid-containing compound biosynthetic process (GO:0009396)3.51503635
64male meiosis (GO:0007140)3.48664472
65L-serine metabolic process (GO:0006563)3.46937508
66positive regulation of astrocyte differentiation (GO:0048711)3.46324444
67peptidyl-proline hydroxylation (GO:0019511)3.46193018
68dendritic spine morphogenesis (GO:0060997)3.44644394
69glomerular basement membrane development (GO:0032836)3.42223941
70lateral sprouting from an epithelium (GO:0060601)3.41099839
71regulation of somitogenesis (GO:0014807)3.40656071
72positive regulation of meiotic cell cycle (GO:0051446)3.36016807
73somite rostral/caudal axis specification (GO:0032525)3.35586851
74lung epithelium development (GO:0060428)3.34571973
75translational termination (GO:0006415)3.33107724
76artery development (GO:0060840)3.31062393
77regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.30653250
78purine nucleobase biosynthetic process (GO:0009113)3.30196026
79protein neddylation (GO:0045116)3.29238408
80nucleobase biosynthetic process (GO:0046112)3.26015201
81protoporphyrinogen IX metabolic process (GO:0046501)3.24814758
82mitotic metaphase plate congression (GO:0007080)3.21972651
83regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.21279589
84regulation of mitotic spindle organization (GO:0060236)3.19534591
85establishment of mitochondrion localization (GO:0051654)3.17282565
86regulation of translational termination (GO:0006449)3.17268012
87establishment of integrated proviral latency (GO:0075713)3.16787914
88regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.13956604
89translational initiation (GO:0006413)3.13901960
90spindle checkpoint (GO:0031577)3.11245609
91positive regulation of synapse assembly (GO:0051965)3.10968124
92endocardial cushion morphogenesis (GO:0003203)3.07849537
93DNA ligation (GO:0006266)3.07837650
94ribosomal small subunit assembly (GO:0000028)3.06624138
95oogenesis (GO:0048477)3.05986963
96chromosome condensation (GO:0030261)3.05749353
97nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.05733889
98oxidative phosphorylation (GO:0006119)3.05651846
99DNA replication-dependent nucleosome organization (GO:0034723)3.03877452
100DNA replication-dependent nucleosome assembly (GO:0006335)3.03877452
101proline metabolic process (GO:0006560)3.03739683
102germ cell migration (GO:0008354)3.02269342
103folic acid-containing compound metabolic process (GO:0006760)3.01392563
104folic acid metabolic process (GO:0046655)3.01200516
105nuclear envelope organization (GO:0006998)3.00814230
106IMP biosynthetic process (GO:0006188)2.97760489
107cotranslational protein targeting to membrane (GO:0006613)2.96034473
108telomere maintenance via recombination (GO:0000722)2.94890692
109translational elongation (GO:0006414)2.94760631
110meiosis I (GO:0007127)2.94673500
111negative regulation of epidermal cell differentiation (GO:0045605)2.92824567
112spermatid nucleus differentiation (GO:0007289)2.92697610
113sex determination (GO:0007530)2.92172558
114negative regulation of protein acetylation (GO:1901984)2.91707062
115mitotic spindle checkpoint (GO:0071174)2.91240302
116regulation of vasculogenesis (GO:2001212)2.90582751
117regulation of dendritic spine morphogenesis (GO:0061001)2.90014912
118pteridine-containing compound biosynthetic process (GO:0042559)2.89119598
119male meiosis I (GO:0007141)2.89075664
120regulation of RNA export from nucleus (GO:0046831)2.88621511
121mitotic chromosome condensation (GO:0007076)2.87847681
122tetrahydrofolate metabolic process (GO:0046653)2.86618709
123response to laminar fluid shear stress (GO:0034616)2.86148266
124mitotic sister chromatid cohesion (GO:0007064)2.84205310
125chaperone-mediated protein complex assembly (GO:0051131)2.83962943
126positive regulation of DNA-dependent DNA replication (GO:2000105)2.83784043
127positive regulation of vasculogenesis (GO:2001214)2.83546551
128protein export from nucleus (GO:0006611)2.83042253
129protein localization to endoplasmic reticulum (GO:0070972)2.82188394
130transcription from mitochondrial promoter (GO:0006390)2.79924278
131protein complex localization (GO:0031503)2.79898274
132retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.79777906
133positive regulation of neuroblast proliferation (GO:0002052)2.79015222
134diterpenoid biosynthetic process (GO:0016102)2.78531503
135ectoderm development (GO:0007398)2.78204576
136mitotic recombination (GO:0006312)2.77874723
137DNA methylation (GO:0006306)2.77864743
138DNA alkylation (GO:0006305)2.77864743
139serine family amino acid biosynthetic process (GO:0009070)2.77717352
140positive regulation of dendritic spine development (GO:0060999)2.77456488
141rRNA processing (GO:0006364)2.77206804
142patterning of blood vessels (GO:0001569)2.77156873
143SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.76841115
144iron ion import (GO:0097286)2.75772398
145spliceosomal tri-snRNP complex assembly (GO:0000244)2.74679249
146cellular response to sterol (GO:0036315)2.74351550
147DNA packaging (GO:0006323)2.74088234
148tricarboxylic acid cycle (GO:0006099)2.73713705
149cellular protein complex localization (GO:0034629)2.73573114
150protein targeting to ER (GO:0045047)2.73137229
151cellular component biogenesis (GO:0044085)2.72934585
152regulation of histone H3-K27 methylation (GO:0061085)2.72649416
153protein localization to chromosome, centromeric region (GO:0071459)2.71732728
154pteridine-containing compound metabolic process (GO:0042558)2.71306963
155regulation of sister chromatid cohesion (GO:0007063)2.70536558
156layer formation in cerebral cortex (GO:0021819)2.70522839
157NADH metabolic process (GO:0006734)2.70311671
158spindle assembly checkpoint (GO:0071173)2.69426181
159viral life cycle (GO:0019058)2.68946904
160exocrine pancreas development (GO:0031017)2.68603484
161mitochondrial DNA metabolic process (GO:0032042)2.68373238
162translation (GO:0006412)2.67176910
163oxaloacetate metabolic process (GO:0006107)2.66956558
164midgut development (GO:0007494)2.66926227
165negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.66257680
166establishment of protein localization to endoplasmic reticulum (GO:0072599)2.65862188
167receptor guanylyl cyclase signaling pathway (GO:0007168)2.65690802
168chondroitin sulfate catabolic process (GO:0030207)2.65458769
169somite development (GO:0061053)2.64762131
170positive regulation of glial cell differentiation (GO:0045687)2.64473109
171meiotic cell cycle process (GO:1903046)2.64389276
172cell proliferation in forebrain (GO:0021846)2.63056254
173regulation of chromosome segregation (GO:0051983)2.62937549
174maturation of 5.8S rRNA (GO:0000460)2.62819192
175mitotic spindle assembly checkpoint (GO:0007094)2.62752389
176cellular protein complex disassembly (GO:0043624)2.62414272
177neuronal stem cell maintenance (GO:0097150)2.62298353
178IMP metabolic process (GO:0046040)2.62181295
179establishment of nucleus localization (GO:0040023)2.60137265
180positive regulation of dendrite morphogenesis (GO:0050775)2.59373245
181positive regulation of megakaryocyte differentiation (GO:0045654)2.59056454
182regulation of spindle organization (GO:0090224)2.56933988

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.85308408
2E2F7_22180533_ChIP-Seq_HELA_Human6.85121426
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.69971929
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse4.59822202
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.32777306
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.91853866
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.82340298
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.73156294
9HTT_18923047_ChIP-ChIP_STHdh_Human3.37070563
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.36759039
11EZH2_22144423_ChIP-Seq_EOC_Human3.33116466
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.17348174
13ZNF263_19887448_ChIP-Seq_K562_Human3.17283513
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.79038289
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.68227555
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.68227555
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.68227555
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.64522357
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59317553
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.59285198
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.54483773
22XRN2_22483619_ChIP-Seq_HELA_Human2.52760778
23POU5F1_16153702_ChIP-ChIP_HESCs_Human2.50495132
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.36188319
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.33460112
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.32773543
27CBX2_27304074_Chip-Seq_ESCs_Mouse2.29793521
28DCP1A_22483619_ChIP-Seq_HELA_Human2.24981344
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24074045
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22120052
31GABP_17652178_ChIP-ChIP_JURKAT_Human2.21812853
32MYC_18555785_ChIP-Seq_MESCs_Mouse2.19935060
33SOX2_18555785_ChIP-Seq_MESCs_Mouse2.19094520
34AR_21909140_ChIP-Seq_LNCAP_Human2.16810140
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.12521318
36THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05351809
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.98212710
38ZFX_18555785_ChIP-Seq_MESCs_Mouse1.96772089
39TTF2_22483619_ChIP-Seq_HELA_Human1.93254335
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.89559782
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.86209359
42VDR_22108803_ChIP-Seq_LS180_Human1.85850363
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82204557
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.80326419
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.77805665
46GABP_19822575_ChIP-Seq_HepG2_Human1.77286965
47DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.76832412
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.72322925
49KDM5A_27292631_Chip-Seq_BREAST_Human1.72204850
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69796641
51CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.67588211
52MYC_22102868_ChIP-Seq_BL_Human1.66756774
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.66179563
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63358490
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62599733
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62465183
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.61488031
58* EZH2_27304074_Chip-Seq_ESCs_Mouse1.59150722
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.57840203
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.57393521
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.56838545
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55165235
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.52511977
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50608804
65TCF3_18692474_ChIP-Seq_MEFs_Mouse1.46235303
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45459220
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44177262
68JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43280760
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43236789
70EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43236789
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42090635
72TFEB_21752829_ChIP-Seq_HELA_Human1.41403856
73CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.40966116
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40891164
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39393085
76NCOR1_26117541_ChIP-Seq_K562_Human1.39246173
77SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.38230263
78RNF2_27304074_Chip-Seq_NSC_Mouse1.37907482
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36177571
80SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.34857968
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34750066
82CHD1_26751641_Chip-Seq_LNCaP_Human1.33836462
83RNF2_27304074_Chip-Seq_ESCs_Mouse1.33792957
84FOXP3_21729870_ChIP-Seq_TREG_Human1.33531226
85TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.33411921
86EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32793911
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31571763
88SRF_21415370_ChIP-Seq_HL-1_Mouse1.31382154
89CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31068338
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30228478
91ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29264438
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29129794
93ELK1_19687146_ChIP-ChIP_HELA_Human1.28284642
94HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27974789
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26808179
96SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26669298
97EED_16625203_ChIP-ChIP_MESCs_Mouse1.25588866
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25065796
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24782893
100MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24494142
101ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.23079028
102YY1_21170310_ChIP-Seq_MESCs_Mouse1.22853244
103ERG_21242973_ChIP-ChIP_JURKAT_Human1.22807769
104SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19859899
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19825261
106SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19748951
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.19606754
108VDR_23849224_ChIP-Seq_CD4+_Human1.18274821
109ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17057604
110POU5F1_16518401_ChIP-PET_MESCs_Mouse1.16703114
111RING1B_27294783_Chip-Seq_NPCs_Mouse1.16388035
112TCF3_18692474_ChIP-Seq_MESCs_Mouse1.16369004
113NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.15868864
114PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15751765
115CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15681582
116ATF3_27146783_Chip-Seq_COLON_Human1.15502117
117CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15374362
118SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.14413230
119RACK7_27058665_Chip-Seq_MCF-7_Human1.14229931
120PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13777994
121CDX2_20551321_ChIP-Seq_CACO-2_Human1.13155407
122SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11507824
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10198586
124SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.08051879
125GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07923354
126EWS_26573619_Chip-Seq_HEK293_Human1.07923254
127GATA1_26923725_Chip-Seq_HPCs_Mouse1.07503471
128CIITA_25753668_ChIP-Seq_RAJI_Human1.07264920
129SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07061510
130E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06650165
131CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06575288
132BP1_19119308_ChIP-ChIP_Hs578T_Human1.04987643
133SMAD3_21741376_ChIP-Seq_EPCs_Human1.04208826
134KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03803370
135KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03701043
136ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02907343
137KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02485408
138SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01462313
139TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00745718
140SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99994924
141KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99559961
142TP53_20018659_ChIP-ChIP_R1E_Mouse0.98569196
143TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98300430
144NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97549625
145EZH2_27294783_Chip-Seq_ESCs_Mouse0.97535080
146ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97311523
147CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95861914
148SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95769351
149SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95386580
150CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93259533
151GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92124166
152NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91465557
153ELK3_25401928_ChIP-Seq_HUVEC_Human0.91124902
154OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91073562
155KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90358393
156FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90275939
157ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89894668
158SOX2_16153702_ChIP-ChIP_HESCs_Human0.89516101
159TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.89279196
160KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.89131374
161UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88752558
162TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88563889
163POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88166383
164SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.87912006
165CLOCK_20551151_ChIP-Seq_293T_Human0.87769173
166MTF2_20144788_ChIP-Seq_MESCs_Mouse0.87766660
167SOX17_20123909_ChIP-Seq_XEN_Mouse0.87156295
168SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86927623
169RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86770402
170ZNF274_21170338_ChIP-Seq_K562_Hela0.86146576
171STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86141004
172TP63_19390658_ChIP-ChIP_HaCaT_Human0.85909649
173P300_19829295_ChIP-Seq_ESCs_Human0.84906974
174NANOG_18692474_ChIP-Seq_MEFs_Mouse0.83428925
175EST1_17652178_ChIP-ChIP_JURKAT_Human0.82821630
176ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80316844
177NANOG_16153702_ChIP-ChIP_HESCs_Human0.79435350
178NANOG_18692474_ChIP-Seq_MESCs_Mouse0.79264358
179WT1_19549856_ChIP-ChIP_CCG9911_Human0.78591344
180SMAD4_21741376_ChIP-Seq_EPCs_Human0.77823187
181FUS_26573619_Chip-Seq_HEK293_Human0.76435917
182NANOG_16518401_ChIP-PET_MESCs_Mouse0.76214035
183FOXM1_26456572_ChIP-Seq_MCF-7_Human0.76168556
184EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.76166173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ4.58943006
2MP0010234_abnormal_vibrissa_follicle3.73418598
3MP0008877_abnormal_DNA_methylation3.61645837
4MP0005451_abnormal_body_composition3.52996235
5MP0008995_early_reproductive_senescence3.14989262
6MP0003136_yellow_coat_color3.09948199
7MP0000383_abnormal_hair_follicle3.03625374
8MP0009697_abnormal_copulation2.96246832
9MP0002877_abnormal_melanocyte_morpholog2.87380093
10MP0003122_maternal_imprinting2.84448465
11MP0005171_absent_coat_pigmentation2.84332787
12MP0008058_abnormal_DNA_repair2.83656624
13MP0003121_genomic_imprinting2.69023400
14MP0004233_abnormal_muscle_weight2.58529129
15MP0002102_abnormal_ear_morphology2.34433396
16MP0008007_abnormal_cellular_replicative2.25069924
17MP0002938_white_spotting2.11120116
18MP0001348_abnormal_lacrimal_gland2.07911509
19MP0003705_abnormal_hypodermis_morpholog2.04984502
20MP0005423_abnormal_somatic_nervous2.04407183
21MP0010678_abnormal_skin_adnexa2.03141214
22MP0003786_premature_aging1.99078986
23MP0003806_abnormal_nucleotide_metabolis1.94465276
24MP0009053_abnormal_anal_canal1.92375738
25MP0003938_abnormal_ear_development1.91944498
26MP0000350_abnormal_cell_proliferation1.91732496
27MP0001145_abnormal_male_reproductive1.85334940
28MP0006138_congestive_heart_failure1.84534288
29MP0004742_abnormal_vestibular_system1.83511940
30MP0008260_abnormal_autophagy1.81291533
31MP0002210_abnormal_sex_determination1.79478415
32MP0001293_anophthalmia1.74484176
33MP0003937_abnormal_limbs/digits/tail_de1.72966611
34MP0001929_abnormal_gametogenesis1.72470829
35MP0001661_extended_life_span1.71865936
36MP0004185_abnormal_adipocyte_glucose1.71538434
37MP0003186_abnormal_redox_activity1.71169464
38MP0003315_abnormal_perineum_morphology1.69816743
39MP0004272_abnormal_basement_membrane1.67111650
40MP0008057_abnormal_DNA_replication1.66318191
41MP0003693_abnormal_embryo_hatching1.61799566
42MP0005595_abnormal_vascular_smooth1.60283954
43MP0002080_prenatal_lethality1.59317182
44MP0006035_abnormal_mitochondrial_morpho1.59187355
45MP0001697_abnormal_embryo_size1.58160122
46MP0003656_abnormal_erythrocyte_physiolo1.56336455
47MP0004957_abnormal_blastocyst_morpholog1.56269199
48MP0000613_abnormal_salivary_gland1.55237272
49MP0003698_abnormal_male_reproductive1.53690242
50MP0002234_abnormal_pharynx_morphology1.53074062
51MP0000678_abnormal_parathyroid_gland1.52782188
52MP0001915_intracranial_hemorrhage1.52187120
53MP0003111_abnormal_nucleus_morphology1.50896507
54MP0002751_abnormal_autonomic_nervous1.49888262
55MP0000920_abnormal_myelination1.47694545
56MP0003632_abnormal_nervous_system1.46190471
57MP0005076_abnormal_cell_differentiation1.45631730
58MP0000778_abnormal_nervous_system1.43343262
59MP0001986_abnormal_taste_sensitivity1.42983544
60MP0006036_abnormal_mitochondrial_physio1.42150281
61MP0000653_abnormal_sex_gland1.40437849
62MP0004147_increased_porphyrin_level1.39258289
63MP0003984_embryonic_growth_retardation1.36377386
64MP0002108_abnormal_muscle_morphology1.34487088
65MP0000358_abnormal_cell_content/1.33848110
66MP0004859_abnormal_synaptic_plasticity1.31986178
67MP0002282_abnormal_trachea_morphology1.31833177
68MP0000313_abnormal_cell_death1.31774095
69MP0002088_abnormal_embryonic_growth/wei1.30218850
70MP0003077_abnormal_cell_cycle1.29418250
71MP0005058_abnormal_lysosome_morphology1.29244779
72MP0003119_abnormal_digestive_system1.29101224
73MP0003861_abnormal_nervous_system1.28398816
74MP0000537_abnormal_urethra_morphology1.26493329
75MP0002086_abnormal_extraembryonic_tissu1.26161011
76MP0003123_paternal_imprinting1.26078863
77MP0000049_abnormal_middle_ear1.25721818
78MP0010307_abnormal_tumor_latency1.25380321
79MP0005501_abnormal_skin_physiology1.25228660
80MP0002089_abnormal_postnatal_growth/wei1.24583935
81MP0001485_abnormal_pinna_reflex1.22190054
82MP0001529_abnormal_vocalization1.21501316
83MP0001881_abnormal_mammary_gland1.20724237
84MP0002254_reproductive_system_inflammat1.19049292
85MP0010094_abnormal_chromosome_stability1.19008890
86MP0000955_abnormal_spinal_cord1.18985206
87MP0009379_abnormal_foot_pigmentation1.18186051
88MP0001177_atelectasis1.18035368
89MP0003950_abnormal_plasma_membrane1.16442537
90MP0000372_irregular_coat_pigmentation1.15196879
91MP0004808_abnormal_hematopoietic_stem1.14055177
92MP0000762_abnormal_tongue_morphology1.12925055
93MP0003718_maternal_effect1.12599665
94MP0000467_abnormal_esophagus_morphology1.10702842
95MP0005085_abnormal_gallbladder_physiolo1.09281141
96MP0008932_abnormal_embryonic_tissue1.07454740
97MP0005330_cardiomyopathy1.07360370
98MP0009278_abnormal_bone_marrow1.06861256
99MP0002152_abnormal_brain_morphology1.05269198
100MP0002161_abnormal_fertility/fecundity1.04746712
101MP0001730_embryonic_growth_arrest1.03887280
102MP0000569_abnormal_digit_pigmentation1.03143694
103MP0003221_abnormal_cardiomyocyte_apopto1.02627836
104MP0010352_gastrointestinal_tract_polyps1.02409397
105MP0005408_hypopigmentation1.02096704
106MP0002653_abnormal_ependyma_morphology1.00340341
107MP0000026_abnormal_inner_ear1.00325697
108MP0002796_impaired_skin_barrier0.98464762
109MP0000631_abnormal_neuroendocrine_gland0.96798303
110MP0002085_abnormal_embryonic_tissue0.95706584
111MP0004858_abnormal_nervous_system0.94894592
112MP0002009_preneoplasia0.94824980
113MP0003755_abnormal_palate_morphology0.94753851
114MP0004197_abnormal_fetal_growth/weight/0.92147952
115MP0000627_abnormal_mammary_gland0.91346215
116MP0004264_abnormal_extraembryonic_tissu0.90827475
117MP0001186_pigmentation_phenotype0.90023315
118MP0005384_cellular_phenotype0.89990956
119MP0009672_abnormal_birth_weight0.89131799
120MP0010030_abnormal_orbit_morphology0.88355308
121MP0003634_abnormal_glial_cell0.88288242
122MP0002233_abnormal_nose_morphology0.87807713
123MP0002396_abnormal_hematopoietic_system0.87643259
124MP0002139_abnormal_hepatobiliary_system0.87053801
125MP0003959_abnormal_lean_body0.85708369
126MP0002060_abnormal_skin_morphology0.84076762
127MP0005621_abnormal_cell_physiology0.83977449
128MP0000747_muscle_weakness0.82752890
129MP0002092_abnormal_eye_morphology0.81999884
130MP0008438_abnormal_cutaneous_collagen0.81304190
131MP0002269_muscular_atrophy0.80827706
132MP0008775_abnormal_heart_ventricle0.80762894
133MP0005623_abnormal_meninges_morphology0.79145197
134MP0005083_abnormal_biliary_tract0.78792754
135MP0002019_abnormal_tumor_incidence0.78560341
136MP0001764_abnormal_homeostasis0.78368993
137MP0002075_abnormal_coat/hair_pigmentati0.76685031
138MP0002970_abnormal_white_adipose0.75809005
139MP0004885_abnormal_endolymph0.74875772
140MP0005380_embryogenesis_phenotype0.74806707
141MP0001672_abnormal_embryogenesis/_devel0.74806707
142MP0001440_abnormal_grooming_behavior0.74626955
143MP0005670_abnormal_white_adipose0.73540310
144MP0001727_abnormal_embryo_implantation0.72268628
145MP0000377_abnormal_hair_follicle0.72008772
146MP0005360_urolithiasis0.71581063
147MP0002736_abnormal_nociception_after0.70747106
148MP0000609_abnormal_liver_physiology0.70701383
149MP0001486_abnormal_startle_reflex0.70680354
150MP0000003_abnormal_adipose_tissue0.70068954
151MP0001958_emphysema0.69850787
152MP0003941_abnormal_skin_development0.69711235
153MP0001216_abnormal_epidermal_layer0.68221988
154MP0003935_abnormal_craniofacial_develop0.67632144
155MP0005409_darkened_coat_color0.67090421
156MP0005257_abnormal_intraocular_pressure0.67089206
157MP0001968_abnormal_touch/_nociception0.67000467
158MP0002111_abnormal_tail_morphology0.66986741
159MP0002882_abnormal_neuron_morphology0.66677951
160MP0003699_abnormal_female_reproductive0.66349429
161MP0002064_seizures0.66163805
162MP0003566_abnormal_cell_adhesion0.66051254
163MP0002084_abnormal_developmental_patter0.65688536
164MP0005395_other_phenotype0.65358526
165MP0005666_abnormal_adipose_tissue0.64900409
166MP0005508_abnormal_skeleton_morphology0.64517317
167MP0003453_abnormal_keratinocyte_physiol0.63928652
168MP0009931_abnormal_skin_appearance0.63820470
169MP0006072_abnormal_retinal_apoptosis0.63806181
170MP0001873_stomach_inflammation0.61171027
171MP0003385_abnormal_body_wall0.59149723

Predicted human phenotypes

RankGene SetZ-score
1Abnormal gallbladder physiology (HP:0012438)4.78543163
2Cholecystitis (HP:0001082)4.78543163
3Agitation (HP:0000713)4.02318660
4Parakeratosis (HP:0001036)3.99566080
5Reticulocytopenia (HP:0001896)3.86957031
6Stenosis of the external auditory canal (HP:0000402)3.80981291
7Hyperthyroidism (HP:0000836)3.63857898
8Reticulocytosis (HP:0001923)3.62571872
9Absent hand (HP:0004050)3.58600368
10Bilateral microphthalmos (HP:0007633)3.57742190
11Truncus arteriosus (HP:0001660)3.39779211
12Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.33747256
13Vertebral hypoplasia (HP:0008417)3.33747256
14Abnormality of reticulocytes (HP:0004312)3.28867536
15Congenital, generalized hypertrichosis (HP:0004540)3.23373916
16Supernumerary ribs (HP:0005815)3.19997728
17Abnormal number of incisors (HP:0011064)3.13327816
18Chromsome breakage (HP:0040012)3.12723438
19Azoospermia (HP:0000027)3.03191557
20Septo-optic dysplasia (HP:0100842)3.02869099
21Ankyloglossia (HP:0010296)3.00350795
22Progressive muscle weakness (HP:0003323)2.98468887
23Sparse lateral eyebrow (HP:0005338)2.98368416
24Birth length less than 3rd percentile (HP:0003561)2.96785465
25Upper limb muscle weakness (HP:0003484)2.89206133
26Short phalanx of the thumb (HP:0009660)2.89173578
27Abnormal spermatogenesis (HP:0008669)2.87742841
28Anophthalmia (HP:0000528)2.83433038
29Duplication of thumb phalanx (HP:0009942)2.83331974
30Cholelithiasis (HP:0001081)2.82115692
31Abnormality of secondary sexual hair (HP:0009888)2.79827314
32Abnormality of the axillary hair (HP:0100134)2.79827314
33Carpal bone hypoplasia (HP:0001498)2.79092700
34Abnormality of cells of the erythroid lineage (HP:0012130)2.74307401
35Decreased central vision (HP:0007663)2.71996568
36Abnormality of the tricuspid valve (HP:0001702)2.71928331
37Degeneration of the lateral corticospinal tracts (HP:0002314)2.68742015
38Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.68742015
39Cone-rod dystrophy (HP:0000548)2.68737031
40Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.68456671
41Short 4th metacarpal (HP:0010044)2.68456671
42Supernumerary bones of the axial skeleton (HP:0009144)2.67552021
43Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.66460101
44Insomnia (HP:0100785)2.65450580
45Hypoparathyroidism (HP:0000829)2.64600788
46Abnormality of the labia minora (HP:0012880)2.61791573
47Pallor (HP:0000980)2.58400274
48Seborrheic dermatitis (HP:0001051)2.58333623
49Spastic paraparesis (HP:0002313)2.58193932
50Aplasia of the musculature (HP:0100854)2.57762402
51Maternal diabetes (HP:0009800)2.55458919
52Ragged-red muscle fibers (HP:0003200)2.48861990
53Fibular hypoplasia (HP:0003038)2.47082818
54Restlessness (HP:0000711)2.44126447
55Increased corneal curvature (HP:0100692)2.44036000
56Keratoconus (HP:0000563)2.44036000
57Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.43142288
58Short 1st metacarpal (HP:0010034)2.43142288
59Abnormal gallbladder morphology (HP:0012437)2.41022509
60Missing ribs (HP:0000921)2.40750784
61Microvesicular hepatic steatosis (HP:0001414)2.38793565
62Dysmetric saccades (HP:0000641)2.36731304
63Abnormality of the distal phalanges of the toes (HP:0010182)2.35474375
64Abnormal large intestine physiology (HP:0012700)2.33588831
65Abnormality of the 1st metacarpal (HP:0010009)2.33587552
66Hypertensive crisis (HP:0100735)2.31750420
67Duplicated collecting system (HP:0000081)2.29867099
68Partial duplication of thumb phalanx (HP:0009944)2.29741540
69Trismus (HP:0000211)2.29316952
70Glossoptosis (HP:0000162)2.28869978
71Abnormal sex determination (HP:0012244)2.28771838
72Sex reversal (HP:0012245)2.28771838
73Macrocytic anemia (HP:0001972)2.27339327
74Progressive external ophthalmoplegia (HP:0000590)2.26789402
75Hyperacusis (HP:0010780)2.26613306
76Overlapping toe (HP:0001845)2.26130841
77Abnormality of oral frenula (HP:0000190)2.24970453
78Down-sloping shoulders (HP:0200021)2.24602183
79Abnormality of the 4th metacarpal (HP:0010012)2.24539617
80Small epiphyses (HP:0010585)2.23578115
81Porencephaly (HP:0002132)2.23405474
82Adactyly (HP:0009776)2.22893741
83Deep venous thrombosis (HP:0002625)2.22690619
84Abnormality of the corticospinal tract (HP:0002492)2.21932229
85Oligodactyly (hands) (HP:0001180)2.20066224
86Entropion (HP:0000621)2.19612332
87Abnormality of the preputium (HP:0100587)2.18632929
88Breast hypoplasia (HP:0003187)2.17889102
89Achilles tendon contracture (HP:0001771)2.17678763
90Gonadal dysgenesis (HP:0000133)2.17582961
91Prenatal maternal abnormality (HP:0002686)2.17554424
92Esophageal atresia (HP:0002032)2.17526297
93Hypobetalipoproteinemia (HP:0003563)2.16995778
94Cutaneous melanoma (HP:0012056)2.15930353
95Oligodactyly (HP:0012165)2.15757906
96Absent septum pellucidum (HP:0001331)2.15006430
97Patellar dislocation (HP:0002999)2.14358979
98Hypokinesia (HP:0002375)2.14219466
99Long clavicles (HP:0000890)2.12968491
100Abnormality of the gallbladder (HP:0005264)2.12879694
101Abnormal number of erythroid precursors (HP:0012131)2.12816867
102Aplasia/Hypoplasia of the sacrum (HP:0008517)2.12397459
103Increased nuchal translucency (HP:0010880)2.12359470
104Aplasia/Hypoplasia involving the musculature (HP:0001460)2.09270838
105Esophageal neoplasm (HP:0100751)2.08643125
106Neoplasm of head and neck (HP:0012288)2.08643125
107Hyperammonemia (HP:0001987)2.08218450
108Absent radius (HP:0003974)2.07813752
109Abnormality of homocysteine metabolism (HP:0010919)2.06321271
110Homocystinuria (HP:0002156)2.06321271
111Partial duplication of the phalanx of hand (HP:0009999)2.06101106
112Myokymia (HP:0002411)2.05803732
113Polycythemia (HP:0001901)2.05559425
11411 pairs of ribs (HP:0000878)2.05506538
115Testicular atrophy (HP:0000029)2.04632092
116Multiple enchondromatosis (HP:0005701)2.04511135
117Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03904618
118Abnormality of the diencephalon (HP:0010662)2.02308326
119Aplasia involving forearm bones (HP:0009822)2.01277879
120Absent forearm bone (HP:0003953)2.01277879
121Neonatal respiratory distress (HP:0002643)2.00567574
122Abnormality of glycolysis (HP:0004366)1.99300587
123Increased serum pyruvate (HP:0003542)1.99300587
124Abnormality of aromatic amino acid family metabolism (HP:0004338)1.98120765
125Toxemia of pregnancy (HP:0100603)1.97462603
126Decreased electroretinogram (ERG) amplitude (HP:0000654)1.96144637
127Insidious onset (HP:0003587)1.96123000
128Termporal pattern (HP:0011008)1.96123000
129Small hand (HP:0200055)1.95763424
130Hyperventilation (HP:0002883)1.94680219
131Chin dimple (HP:0010751)1.94569436
132Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94391156
133Cortical dysplasia (HP:0002539)1.93029379
134Increased connective tissue (HP:0009025)1.92498214
135Split hand (HP:0001171)1.92193564
136Acute encephalopathy (HP:0006846)1.91856494
137Secondary amenorrhea (HP:0000869)1.91840020
138Long palpebral fissure (HP:0000637)1.90370297
139Orthostatic hypotension (HP:0001278)1.89829728
140Rough bone trabeculation (HP:0100670)1.89696097
141Cerebral edema (HP:0002181)1.89453073
142Abnormal lung lobation (HP:0002101)1.89244696
143Abnormality of the Achilles tendon (HP:0005109)1.88722347
144Neoplasm of the heart (HP:0100544)1.88708415
145Sensory axonal neuropathy (HP:0003390)1.87816662
146Gaze-evoked nystagmus (HP:0000640)1.87657446
147Pili torti (HP:0003777)1.87304402
148Elbow flexion contracture (HP:0002987)1.87138481
149Paralysis (HP:0003470)1.86414142
150Paraparesis (HP:0002385)1.86406364
151Fatigue (HP:0012378)1.86041865
152Gonadotropin excess (HP:0000837)1.85270489
153Skull defect (HP:0001362)1.84960919
154Short thumb (HP:0009778)1.84580510
155Neonatal short-limb short stature (HP:0008921)1.84428100
156Pseudobulbar signs (HP:0002200)1.83677128
157Premature ovarian failure (HP:0008209)1.83655801
158Esophageal varix (HP:0002040)1.83055832
159Myelodysplasia (HP:0002863)1.82322822
160Unilateral renal agenesis (HP:0000122)1.82141815
161Cerebral hypomyelination (HP:0006808)1.82080785
162Neoplasm of striated muscle (HP:0009728)1.80990301
163Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.80762281
164Spastic tetraparesis (HP:0001285)1.80287363
165Premature rupture of membranes (HP:0001788)1.80267951
166Vertebral compression fractures (HP:0002953)1.79304025
167Synostosis of carpal bones (HP:0005048)1.78865408
168Calcaneovalgus deformity (HP:0001848)1.78722539
169Persistence of primary teeth (HP:0006335)1.78144168
170Abnormal hemoglobin (HP:0011902)1.77985401
171Abnormality of the calcaneus (HP:0008364)1.77898796
172Atelectasis (HP:0100750)1.77850903
173Abnormality of the septum pellucidum (HP:0007375)1.77696011
174Overriding aorta (HP:0002623)1.77402621
175Abnormal mitochondria in muscle tissue (HP:0008316)1.76675627
176Abnormality of subcutaneous fat tissue (HP:0001001)1.75856341
177Morphological abnormality of the inner ear (HP:0011390)1.75820813
178Short tibia (HP:0005736)1.75688032
179Abnormality of cochlea (HP:0000375)1.75585330
180Patchy hypopigmentation of hair (HP:0011365)1.75375672
181Bowel incontinence (HP:0002607)1.75082105
182Abnormality of the umbilical cord (HP:0010881)1.74535155
183Hyperbilirubinemia (HP:0002904)1.73585347
184Diaphragmatic weakness (HP:0009113)1.69388558
185Abnormality of sulfur amino acid metabolism (HP:0004339)1.68634116
186Increased serum lactate (HP:0002151)1.67218437
187Poikiloderma (HP:0001029)1.66779673
188Ureteral duplication (HP:0000073)1.65924130
189White forelock (HP:0002211)1.65077670
190Abnormally folded helix (HP:0008544)1.64907452
191Submucous cleft hard palate (HP:0000176)1.64300346
192Cafe-au-lait spot (HP:0000957)1.63949198
193Abnormality of pyrimidine metabolism (HP:0004353)1.63476382

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.27718091
2STK164.50263553
3KDR4.29144164
4EIF2AK13.92714303
5NUAK13.27980453
6MST1R3.18628608
7EEF2K3.15829610
8PBK3.07811642
9EPHB22.95500550
10IRAK32.89495368
11WEE12.88877047
12ICK2.84976794
13EPHA22.65259286
14TSSK62.53140244
15NEK12.42597860
16NME22.34736455
17BRSK22.21588787
18SCYL22.05172649
19TIE12.04106895
20TRIB31.97393927
21SMG11.90084058
22PRKD31.82300234
23LATS11.74631592
24CCNB11.65652028
25KSR21.65312711
26BCR1.64067901
27RPS6KB21.62824821
28SRPK11.56655121
29KSR11.53714555
30EPHB11.50983688
31GRK11.49239706
32PAK41.48708008
33EIF2AK31.39034277
34STK381.37181464
35PDK41.36386597
36PDK31.36386597
37ACVR1B1.35536151
38PKN21.34941547
39BRSK11.34842354
40MET1.31432995
41ERBB41.30755420
42STK38L1.30300928
43PKN11.28585471
44SIK11.19934002
45CHEK21.17486426
46RAF11.15332462
47BRAF1.14007729
48DYRK21.12607103
49EIF2AK21.12132574
50STK391.11558012
51LRRK21.10587870
52FGR1.10272711
53ARAF1.06888537
54NTRK11.04199960
55ERBB21.04109923
56MARK31.03158031
57NTRK31.02044394
58MKNK11.00773108
59MAP3K30.97936938
60WNK40.95217312
61BMPR20.95060926
62TAOK20.91118835
63AURKB0.89130081
64CDC70.88096001
65CDK190.86280532
66PDK20.84749371
67ILK0.84016928
68PLK30.83992697
69PASK0.83080150
70MTOR0.81680304
71BMPR1B0.81440001
72ATR0.80038076
73AKT20.79100009
74ALK0.76879462
75STK100.76018518
76DYRK30.72808571
77PLK10.72469390
78PRPF4B0.72377421
79VRK20.72056913
80LIMK10.71595282
81SGK4940.70897207
82SGK2230.70897207
83MAP3K90.69755943
84MAPKAPK30.66844141
85CDK120.66298979
86ERN10.65488412
87AURKA0.61056311
88MELK0.59192060
89PRKCI0.57641888
90PAK30.57138230
91CAMK2B0.57115213
92MAPK70.56906003
93MAP3K20.56683894
94UHMK10.55353697
95WNK10.54479790
96BLK0.54067670
97TESK20.53856814
98SIK30.52925805
99AKT30.52836181
100CDK80.52349527
101PLK40.52200092
102CDK10.51333795
103CSNK1G10.50908443
104CDK70.50571178
105TNK20.49515526
106CSNK2A20.49421806
107NTRK20.48140715
108PTK20.47117714
109INSR0.44972118
110ATM0.44605771
111NEK60.43981942
112CDK40.43940238
113BRD40.43006562
114CHEK10.42789689
115CDK90.42360901
116MAP3K80.42095768
117PAK10.41726865
118STK240.40971702
119BMX0.40969926
120PIM20.40863718
121MARK10.40849301
122PAK20.40559117
123FLT30.40310078
124MST40.39383930
125MAPKAPK50.39196260
126MKNK20.38922674
127NME10.38718932
128PLK20.38684281
129CAMK2D0.37565540
130NEK20.37534711
131CLK10.36785415
132PTK60.35951108
133MAP3K130.35676418
134CAMK1D0.34295471
135STK30.33828889
136OXSR10.32737399
137PRKCG0.32496132
138ROCK20.32211210
139CSNK1E0.31576372
140RIPK40.31343315
141PNCK0.31308264
142IRAK20.31114435
143RPS6KA40.30600872
144CSNK2A10.30451154
145CAMK2A0.30238543
146STK40.29919079
147MAP2K30.29750741
148TTK0.29226772
149FES0.29192834
150MAP3K10.28099522
151CDK20.26112651
152DYRK1B0.24783192
153GSK3A0.21710826
154EGFR0.21538362
155LATS20.20404757

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.14187129
2Proteasome_Homo sapiens_hsa030503.61536047
3Nitrogen metabolism_Homo sapiens_hsa009103.18660430
4RNA polymerase_Homo sapiens_hsa030203.17244098
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.08852673
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.03455585
7Biosynthesis of amino acids_Homo sapiens_hsa012302.51554847
8Steroid biosynthesis_Homo sapiens_hsa001002.28494028
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15468019
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.10989672
11Phototransduction_Homo sapiens_hsa047442.07695999
12Basal transcription factors_Homo sapiens_hsa030222.06155238
13Vitamin B6 metabolism_Homo sapiens_hsa007502.02281988
14Carbon metabolism_Homo sapiens_hsa012001.97324548
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.91954619
16Oocyte meiosis_Homo sapiens_hsa041141.87525873
17Pentose phosphate pathway_Homo sapiens_hsa000301.82712916
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81538607
19Base excision repair_Homo sapiens_hsa034101.79777039
20Linoleic acid metabolism_Homo sapiens_hsa005911.78358358
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.77135177
22Fructose and mannose metabolism_Homo sapiens_hsa000511.76945467
23Butanoate metabolism_Homo sapiens_hsa006501.76332294
24Mismatch repair_Homo sapiens_hsa034301.74838897
25Fatty acid elongation_Homo sapiens_hsa000621.73168936
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.67811643
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.61300625
28Homologous recombination_Homo sapiens_hsa034401.56645031
29Ether lipid metabolism_Homo sapiens_hsa005651.54064032
30Dorso-ventral axis formation_Homo sapiens_hsa043201.51920690
31Ovarian steroidogenesis_Homo sapiens_hsa049131.50814333
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49360054
33Spliceosome_Homo sapiens_hsa030401.46267937
34Sulfur relay system_Homo sapiens_hsa041221.44993156
35Axon guidance_Homo sapiens_hsa043601.41048920
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39723277
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.36001058
38Cell cycle_Homo sapiens_hsa041101.34309646
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.30121783
40Thyroid cancer_Homo sapiens_hsa052161.23978687
41Fatty acid metabolism_Homo sapiens_hsa012121.23645975
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15400570
43Phenylalanine metabolism_Homo sapiens_hsa003601.15330148
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15255924
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13702311
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13629929
47Tight junction_Homo sapiens_hsa045301.12472489
48DNA replication_Homo sapiens_hsa030301.09699544
49Drug metabolism - other enzymes_Homo sapiens_hsa009831.08743034
50N-Glycan biosynthesis_Homo sapiens_hsa005101.08052404
51Folate biosynthesis_Homo sapiens_hsa007901.07376752
52Basal cell carcinoma_Homo sapiens_hsa052171.06369163
53Arginine and proline metabolism_Homo sapiens_hsa003301.06059397
54PPAR signaling pathway_Homo sapiens_hsa033201.05593250
55RNA transport_Homo sapiens_hsa030131.04551722
56Central carbon metabolism in cancer_Homo sapiens_hsa052301.04054380
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00564933
58Oxidative phosphorylation_Homo sapiens_hsa001900.99408790
59Hedgehog signaling pathway_Homo sapiens_hsa043400.99378596
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98099987
61Pyrimidine metabolism_Homo sapiens_hsa002400.97716900
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.97380143
63Huntingtons disease_Homo sapiens_hsa050160.97212075
64Retinol metabolism_Homo sapiens_hsa008300.95853733
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94808307
66ECM-receptor interaction_Homo sapiens_hsa045120.93406344
67Nucleotide excision repair_Homo sapiens_hsa034200.89191236
68Propanoate metabolism_Homo sapiens_hsa006400.88154269
69Notch signaling pathway_Homo sapiens_hsa043300.88012497
70Galactose metabolism_Homo sapiens_hsa000520.87737403
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.87536300
72Hippo signaling pathway_Homo sapiens_hsa043900.86970915
73One carbon pool by folate_Homo sapiens_hsa006700.86626808
74RNA degradation_Homo sapiens_hsa030180.86257057
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85936924
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84020766
77Tyrosine metabolism_Homo sapiens_hsa003500.83990423
78Fatty acid degradation_Homo sapiens_hsa000710.81003472
79Chronic myeloid leukemia_Homo sapiens_hsa052200.80945825
80Glutathione metabolism_Homo sapiens_hsa004800.79745735
81Long-term depression_Homo sapiens_hsa047300.75704266
82Prion diseases_Homo sapiens_hsa050200.72642994
83Pyruvate metabolism_Homo sapiens_hsa006200.70183037
84Fatty acid biosynthesis_Homo sapiens_hsa000610.69578660
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68441761
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67453599
87Adherens junction_Homo sapiens_hsa045200.67274820
88Rap1 signaling pathway_Homo sapiens_hsa040150.65852333
89Tryptophan metabolism_Homo sapiens_hsa003800.65211560
90Bladder cancer_Homo sapiens_hsa052190.63682754
91Cardiac muscle contraction_Homo sapiens_hsa042600.63615409
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63090598
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63005350
94Epstein-Barr virus infection_Homo sapiens_hsa051690.62944715
95Lysine degradation_Homo sapiens_hsa003100.62784872
96Non-small cell lung cancer_Homo sapiens_hsa052230.62511518
97Sulfur metabolism_Homo sapiens_hsa009200.62227583
98Purine metabolism_Homo sapiens_hsa002300.60818671
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59650502
100Parkinsons disease_Homo sapiens_hsa050120.59481791
101TGF-beta signaling pathway_Homo sapiens_hsa043500.59278180
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57557158
103Fat digestion and absorption_Homo sapiens_hsa049750.57200013
104mRNA surveillance pathway_Homo sapiens_hsa030150.57183292
105Complement and coagulation cascades_Homo sapiens_hsa046100.57066387
106Histidine metabolism_Homo sapiens_hsa003400.54509042
107Pancreatic cancer_Homo sapiens_hsa052120.54482763
108Fanconi anemia pathway_Homo sapiens_hsa034600.54212980
109Vibrio cholerae infection_Homo sapiens_hsa051100.52156217
110Bile secretion_Homo sapiens_hsa049760.51762792
111Metabolic pathways_Homo sapiens_hsa011000.51655302
112Starch and sucrose metabolism_Homo sapiens_hsa005000.50323286
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50177891
114Renin-angiotensin system_Homo sapiens_hsa046140.49601356
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.49006964
116Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48964092
117Arachidonic acid metabolism_Homo sapiens_hsa005900.48919719
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48126135
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47115265
120Acute myeloid leukemia_Homo sapiens_hsa052210.46309084
121Protein export_Homo sapiens_hsa030600.46001619
122Olfactory transduction_Homo sapiens_hsa047400.45496551
123Viral carcinogenesis_Homo sapiens_hsa052030.44603029
124Small cell lung cancer_Homo sapiens_hsa052220.43499804
125p53 signaling pathway_Homo sapiens_hsa041150.43492302
126Ras signaling pathway_Homo sapiens_hsa040140.43162869
127Renal cell carcinoma_Homo sapiens_hsa052110.43081806
128mTOR signaling pathway_Homo sapiens_hsa041500.42935315
129Arginine biosynthesis_Homo sapiens_hsa002200.42927194
130MicroRNAs in cancer_Homo sapiens_hsa052060.40323941
131Non-homologous end-joining_Homo sapiens_hsa034500.40069499
132Insulin signaling pathway_Homo sapiens_hsa049100.40061884
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39923227
134Glutamatergic synapse_Homo sapiens_hsa047240.39311971
135Mineral absorption_Homo sapiens_hsa049780.38858654
136Gap junction_Homo sapiens_hsa045400.38581888
137Alzheimers disease_Homo sapiens_hsa050100.38572563
138Prostate cancer_Homo sapiens_hsa052150.37685331
139Renin secretion_Homo sapiens_hsa049240.35414261
140Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34950941
141Dilated cardiomyopathy_Homo sapiens_hsa054140.34788137
142Endometrial cancer_Homo sapiens_hsa052130.34187880
143ErbB signaling pathway_Homo sapiens_hsa040120.33994919
144Pathways in cancer_Homo sapiens_hsa052000.33701839
145HIF-1 signaling pathway_Homo sapiens_hsa040660.32128289
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.31819120
147Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31517880
148Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31478237
149Selenocompound metabolism_Homo sapiens_hsa004500.31042597
150VEGF signaling pathway_Homo sapiens_hsa043700.30635383
151Other glycan degradation_Homo sapiens_hsa005110.29031962
152Glioma_Homo sapiens_hsa052140.25343253
153Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25203493
154Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.22921572

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »