MAGEA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H4-K12 acetylation (GO:0043983)5.66589710
2negative regulation of catenin import into nucleus (GO:0035414)5.65489609
3regulation of telomere maintenance via telomerase (GO:0032210)5.60780622
4protein localization to kinetochore (GO:0034501)5.43519727
5regulation of posttranscriptional gene silencing (GO:0060147)5.42261976
6regulation of gene silencing by miRNA (GO:0060964)5.42261976
7regulation of gene silencing by RNA (GO:0060966)5.42261976
8negative regulation of telomerase activity (GO:0051974)5.33633644
9Golgi transport vesicle coating (GO:0048200)5.17459714
10COPI coating of Golgi vesicle (GO:0048205)5.17459714
11mitotic sister chromatid segregation (GO:0000070)5.15709745
12ribosomal small subunit biogenesis (GO:0042274)4.98518816
13heterochromatin organization (GO:0070828)4.90782611
14ribosomal small subunit assembly (GO:0000028)4.74680926
15polyketide metabolic process (GO:0030638)4.69257192
16doxorubicin metabolic process (GO:0044598)4.69257192
17daunorubicin metabolic process (GO:0044597)4.69257192
18negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.69211579
19histone H4-K8 acetylation (GO:0043982)4.68619097
20histone H4-K5 acetylation (GO:0043981)4.68619097
21ribosome assembly (GO:0042255)4.58661708
22regulation of nuclear cell cycle DNA replication (GO:0033262)4.50996869
23nuclear pore complex assembly (GO:0051292)4.49424950
24kidney mesenchyme development (GO:0072074)4.43913935
25DNA replication-dependent nucleosome organization (GO:0034723)4.41015446
26DNA replication-dependent nucleosome assembly (GO:0006335)4.41015446
27regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.39232539
28sister chromatid segregation (GO:0000819)4.38730123
29cell fate commitment involved in formation of primary germ layer (GO:0060795)4.33545722
30protein localization to chromosome, centromeric region (GO:0071459)4.33440829
31negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.31864871
32nuclear pore organization (GO:0006999)4.29848465
33establishment of apical/basal cell polarity (GO:0035089)4.23456559
34transcription from mitochondrial promoter (GO:0006390)4.20717488
35regulation of mammary gland epithelial cell proliferation (GO:0033599)4.11849896
36somatic hypermutation of immunoglobulin genes (GO:0016446)4.11301763
37somatic diversification of immune receptors via somatic mutation (GO:0002566)4.11301763
38maintenance of protein location in nucleus (GO:0051457)4.07680573
39somite rostral/caudal axis specification (GO:0032525)4.02207798
40peripheral nervous system neuron development (GO:0048935)4.00448855
41pre-miRNA processing (GO:0031054)3.97949616
42notochord development (GO:0030903)3.96398752
43chromatin assembly (GO:0031497)3.96114818
44negative regulation of telomere maintenance (GO:0032205)3.95422482
45replication fork processing (GO:0031297)3.93156678
46meiotic chromosome segregation (GO:0045132)3.91984435
47determination of adult lifespan (GO:0008340)3.89312536
48ribonucleoprotein complex biogenesis (GO:0022613)3.86974568
49generation of neurons (GO:0048699)3.86507941
50negative regulation of cell cycle G2/M phase transition (GO:1902750)3.84537420
51viral transcription (GO:0019083)3.84329953
52metanephric mesenchyme development (GO:0072075)3.80752321
53myoblast migration (GO:0051451)3.79865029
54DNA duplex unwinding (GO:0032508)3.78744278
55DNA geometric change (GO:0032392)3.77482957
56ribosomal large subunit biogenesis (GO:0042273)3.71577997
57translational termination (GO:0006415)3.69702544
58DNA replication checkpoint (GO:0000076)3.66961094
59regulation of meiosis I (GO:0060631)3.65874490
60maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.61928065
61establishment or maintenance of monopolar cell polarity (GO:0061339)3.61671891
62establishment of monopolar cell polarity (GO:0061162)3.61671891
63regulation of double-strand break repair (GO:2000779)3.60947421
64rRNA transcription (GO:0009303)3.60544944
65mitochondrial DNA metabolic process (GO:0032042)3.60215016
66formation of translation preinitiation complex (GO:0001731)3.59699860
67piRNA metabolic process (GO:0034587)3.58101293
68translational initiation (GO:0006413)3.56227414
69mitotic chromosome condensation (GO:0007076)3.56086664
70DNA unwinding involved in DNA replication (GO:0006268)3.55512144
71regulation of apoptotic process involved in morphogenesis (GO:1902337)3.55286997
72negative regulation of epidermis development (GO:0045683)3.51814869
73mesenchyme development (GO:0060485)3.49455674
74nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.47669411
75DNA replication initiation (GO:0006270)3.45940602
76regulation of gonadotropin secretion (GO:0032276)3.44815853
77negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.43993359
78rRNA modification (GO:0000154)3.42344581
79SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.42100195
80establishment of integrated proviral latency (GO:0075713)3.39084629
81regulation of telomere maintenance (GO:0032204)3.39066688
82rRNA methylation (GO:0031167)3.38418598
83embryonic process involved in female pregnancy (GO:0060136)3.38046013
84kinetochore assembly (GO:0051382)3.32191923
85translational elongation (GO:0006414)3.30493532
86trophectodermal cell differentiation (GO:0001829)3.30369347
87cotranslational protein targeting to membrane (GO:0006613)3.30353003
88regulation of cilium movement (GO:0003352)3.29483075
89protein targeting to ER (GO:0045047)3.28731999
90histone H4-K16 acetylation (GO:0043984)3.27347904
91kinetochore organization (GO:0051383)3.26267242
92intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.26068099
93histone arginine methylation (GO:0034969)3.25114808
94regulation of hippo signaling (GO:0035330)3.24361522
95pore complex assembly (GO:0046931)3.23764069
96regulation of chromatin binding (GO:0035561)3.23641844
97mitotic nuclear envelope disassembly (GO:0007077)3.22351459
98regulation of helicase activity (GO:0051095)3.21840856
99branching involved in mammary gland duct morphogenesis (GO:0060444)3.19728265
100anterior/posterior axis specification, embryo (GO:0008595)3.19498002
101establishment of protein localization to endoplasmic reticulum (GO:0072599)3.17988851
102regulation of telomerase activity (GO:0051972)3.16559987
103attachment of spindle microtubules to kinetochore (GO:0008608)3.16441437
104positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.15041263
105spliceosomal tri-snRNP complex assembly (GO:0000244)3.14525831
106DNA strand renaturation (GO:0000733)3.14451277
107protein localization to endoplasmic reticulum (GO:0070972)3.13259243
108trophoblast giant cell differentiation (GO:0060707)3.12877466
109proline biosynthetic process (GO:0006561)3.12670024
110muscle organ morphogenesis (GO:0048644)3.12315885
111negative regulation of DNA repair (GO:0045738)3.11103808
112regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.10525101
113DNA conformation change (GO:0071103)3.09791533
114mitochondrial fusion (GO:0008053)3.09770493
115viral life cycle (GO:0019058)3.08703697
116mitotic G1 DNA damage checkpoint (GO:0031571)3.08600548
117spindle assembly (GO:0051225)3.07463843
118regulation of RNA export from nucleus (GO:0046831)3.05612051
119negative regulation of homotypic cell-cell adhesion (GO:0034111)3.05525493
120ribosome biogenesis (GO:0042254)3.04223759
121intestinal epithelial cell development (GO:0060576)3.04122463
122retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.03903116
123regulation of double-strand break repair via homologous recombination (GO:0010569)3.03786799
124planar cell polarity pathway involved in neural tube closure (GO:0090179)3.03248083
125mRNA stabilization (GO:0048255)3.02927560
126RNA stabilization (GO:0043489)3.02927560
127maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.00260727
128embryonic placenta development (GO:0001892)2.99872999
129primitive streak formation (GO:0090009)2.99321859
130regulation of translational fidelity (GO:0006450)2.97391326
131nuclear envelope disassembly (GO:0051081)2.97100459
132membrane disassembly (GO:0030397)2.97100459
133cellular protein complex disassembly (GO:0043624)2.96649750
134regulation of response to osmotic stress (GO:0047484)2.96092033
135negative regulation of gene silencing (GO:0060969)2.94422452
136regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.92585612
137activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.90916109
138regulation of gene silencing (GO:0060968)2.90809368
139hippo signaling (GO:0035329)2.89090395
140negative regulation of chromosome segregation (GO:0051985)2.88512659
141aminoglycoside antibiotic metabolic process (GO:0030647)2.86536716
142proximal/distal pattern formation (GO:0009954)2.85404307
143cullin deneddylation (GO:0010388)2.84938910
144positive regulation of nuclease activity (GO:0032075)2.84233562
145maternal placenta development (GO:0001893)2.83603365
146positive regulation of SMAD protein import into nucleus (GO:0060391)2.83266851
147G1 DNA damage checkpoint (GO:0044783)2.81422738
148regulation of nucleobase-containing compound transport (GO:0032239)2.77294777
149regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.76298760
150endoplasmic reticulum unfolded protein response (GO:0030968)2.71926833
151protein maturation by protein folding (GO:0022417)2.71121371
152protein complex disassembly (GO:0043241)2.70777146
153protein retention in ER lumen (GO:0006621)2.70666884
154mitotic metaphase plate congression (GO:0007080)2.67898029
155muscle cell migration (GO:0014812)2.67113412
156nucleobase-containing small molecule interconversion (GO:0015949)2.66004805
157establishment of viral latency (GO:0019043)2.65688703
158positive regulation of astrocyte differentiation (GO:0048711)2.65536677
159regulation of translational initiation (GO:0006446)2.65326097
160protein targeting to membrane (GO:0006612)2.64833448
161negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.63916852
162regulation of nuclease activity (GO:0032069)2.62964107
163myeloid cell homeostasis (GO:0002262)2.62427134
164macromolecular complex disassembly (GO:0032984)2.61888293
165chromosome condensation (GO:0030261)2.60559361
166chondrocyte proliferation (GO:0035988)2.57160420
167regulation of translational termination (GO:0006449)2.56608070
168maturation of SSU-rRNA (GO:0030490)2.56446616
169G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.54647415
170protein complex localization (GO:0031503)2.54516416
171cellular response to unfolded protein (GO:0034620)2.53637768
172negative regulation of cell size (GO:0045792)2.53505663
173basement membrane organization (GO:0071711)2.49646606
174ER-nucleus signaling pathway (GO:0006984)2.47903400
175negative regulation of necroptotic process (GO:0060546)2.46705152
176regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.46641171
177enteric nervous system development (GO:0048484)2.46257825
178translation (GO:0006412)2.46088510
179cellular protein complex localization (GO:0034629)2.45062440
180mesoderm development (GO:0007498)2.44063018
181ncRNA 3-end processing (GO:0043628)2.44008657
182activation of Rac GTPase activity (GO:0032863)2.43907591
183snRNA metabolic process (GO:0016073)2.43482707
184segment specification (GO:0007379)2.42408602
185mesodermal cell differentiation (GO:0048333)2.42184151
186tRNA aminoacylation for protein translation (GO:0006418)2.41732042
187cellular component biogenesis (GO:0044085)2.41198997
188gonadal mesoderm development (GO:0007506)17.1168090

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.58878562
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.51219139
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.51219139
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.51219139
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.90358677
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.51365987
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.37017764
8NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.29724018
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.08974818
10POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.93472529
11SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.91249977
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.78366988
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.76557406
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.73602845
15TCF3_18692474_ChIP-Seq_MESCs_Mouse2.68412464
16TCF3_18692474_ChIP-Seq_MEFs_Mouse2.67112538
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.62594506
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.53240023
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52436778
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.49808432
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.45973735
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.35882592
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.31531266
24STAT3_1855785_ChIP-Seq_MESCs_Mouse2.16921955
25DCP1A_22483619_ChIP-Seq_HELA_Human2.14211899
26TP63_19390658_ChIP-ChIP_HaCaT_Human2.13571704
27ZNF263_19887448_ChIP-Seq_K562_Human2.12183058
28POU5F1_16518401_ChIP-PET_MESCs_Mouse2.11655114
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.11305610
30CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.06936098
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05043372
32NANOG_18555785_ChIP-Seq_MESCs_Mouse2.04410017
33SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.02744267
34BP1_19119308_ChIP-ChIP_Hs578T_Human2.00691461
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00418842
36NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.98561987
37KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.97833633
38NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.96232227
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.92523233
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.90630326
41GABP_19822575_ChIP-Seq_HepG2_Human1.89994237
42POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.89027949
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.87218038
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85577578
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84184903
46SOX2_18555785_ChIP-Seq_MESCs_Mouse1.78883957
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76728428
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75734480
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73431262
50TFEB_21752829_ChIP-Seq_HELA_Human1.73183574
51TP63_17297297_ChIP-ChIP_HaCaT_Human1.70161136
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67831008
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66395184
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.66074027
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64596742
56P300_27058665_Chip-Seq_ZR-75-30cells_Human1.63514854
57CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.63325572
58EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.63079130
59WT1_19549856_ChIP-ChIP_CCG9911_Human1.61661068
60CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.61269725
61NANOG_18692474_ChIP-Seq_MESCs_Mouse1.57570825
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.55118906
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54396453
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54152053
65TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.53903424
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53235242
67NANOG_18692474_ChIP-Seq_MEFs_Mouse1.53037590
68SOX2_18692474_ChIP-Seq_MEFs_Mouse1.51552181
69ELK1_19687146_ChIP-ChIP_HELA_Human1.50946849
70SOX2_18692474_ChIP-Seq_MESCs_Mouse1.50883481
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.49196130
72POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.46349219
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43801961
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.43752104
75CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.43015383
76OCT4_18692474_ChIP-Seq_MEFs_Mouse1.39967332
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35699202
78PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.35521893
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34929357
80SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.34854863
81ATF3_27146783_Chip-Seq_COLON_Human1.33898860
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33267078
83NANOG_16518401_ChIP-PET_MESCs_Mouse1.32693688
84IRF1_19129219_ChIP-ChIP_H3396_Human1.30857737
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30347357
86RACK7_27058665_Chip-Seq_MCF-7_Human1.29014753
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28957523
88ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.26165305
89RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25989855
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.25466469
91NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24995612
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24774345
93TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24588338
94ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24465552
95MYC_22102868_ChIP-Seq_BL_Human1.24387395
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24007288
97ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23856315
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23515574
99E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20463064
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20088532
101MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19985207
102KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19980626
103CHD1_26751641_Chip-Seq_LNCaP_Human1.18652602
104TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17957291
105SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17708161
106SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16424045
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16185164
108UBF1/2_26484160_Chip-Seq_HMECs_Human1.15230424
109ELK1_22589737_ChIP-Seq_MCF10A_Human1.14804423
110SOX17_20123909_ChIP-Seq_XEN_Mouse1.14126509
111TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13804961
112SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13343427
113VDR_23849224_ChIP-Seq_CD4+_Human1.13064346
114FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11425428
115CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10518860
116AR_21909140_ChIP-Seq_LNCAP_Human1.09972891
117FOXP3_21729870_ChIP-Seq_TREG_Human1.09956260
118HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09637343
119NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.08827546
120KAP1_27257070_Chip-Seq_ESCs_Mouse1.08541305
121TBX5_21415370_ChIP-Seq_HL-1_Mouse1.08468104
122POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08367411
123XRN2_22483619_ChIP-Seq_HELA_Human1.07790850
124HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03907110
125RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03625053
126ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01155101
127E2F1_17053090_ChIP-ChIP_MCF-7_Human0.96759349
128E2F1_21310950_ChIP-Seq_MCF-7_Human0.96494557
129EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92719362
130STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92192760
131MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91164596
132CREB1_15753290_ChIP-ChIP_HEK293T_Human0.88924805
133TTF2_22483619_ChIP-Seq_HELA_Human0.88278436
134EST1_17652178_ChIP-ChIP_JURKAT_Human0.87366933
135TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86131456
136NANOG_16153702_ChIP-ChIP_HESCs_Human0.85982514
137ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85805012
138TBX3_20139965_ChIP-Seq_MESCs_Mouse0.84884155
139GATA1_26923725_Chip-Seq_HPCs_Mouse0.84657780
140KDM5A_27292631_Chip-Seq_BREAST_Human0.82997183
141TP53_22127205_ChIP-Seq_IMR90_Human0.82481654
142ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81897006
143ERG_21242973_ChIP-ChIP_JURKAT_Human0.81764071
144EGR1_19374776_ChIP-ChIP_THP-1_Human0.80098156
145THAP11_20581084_ChIP-Seq_MESCs_Mouse0.78803908
146SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.78639435
147POU5F1_16153702_ChIP-ChIP_HESCs_Human0.78472147
148SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77897556
149STAT3_18555785_ChIP-Seq_MESCs_Mouse0.77875048
150RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.76447539
151YY1_22570637_ChIP-Seq_MALME-3M_Human0.75328392
152DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.74082839
153CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.73816702
154NCOR1_26117541_ChIP-Seq_K562_Human0.73781263

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.41474713
2MP0008438_abnormal_cutaneous_collagen3.85887572
3MP0002877_abnormal_melanocyte_morpholog3.77574583
4MP0004957_abnormal_blastocyst_morpholog3.54161729
5MP0010030_abnormal_orbit_morphology3.51542112
6MP0003890_abnormal_embryonic-extraembry3.22052373
7MP0004264_abnormal_extraembryonic_tissu3.04597011
8MP0003011_delayed_dark_adaptation2.91792270
9MP0005408_hypopigmentation2.88577375
10MP0010094_abnormal_chromosome_stability2.80083581
11MP0003111_abnormal_nucleus_morphology2.79730989
12MP0002653_abnormal_ependyma_morphology2.67360725
13MP0005623_abnormal_meninges_morphology2.50185034
14MP0000733_abnormal_muscle_development2.49228233
15MP0006292_abnormal_olfactory_placode2.48545044
16MP0002254_reproductive_system_inflammat2.45451731
17MP0010352_gastrointestinal_tract_polyps2.42545584
18MP0003077_abnormal_cell_cycle2.33927021
19MP0005075_abnormal_melanosome_morpholog2.23539961
20MP0008877_abnormal_DNA_methylation2.23095447
21MP0005451_abnormal_body_composition2.20996869
22MP0005503_abnormal_tendon_morphology2.11335511
23MP0003705_abnormal_hypodermis_morpholog2.01377655
24MP0005380_embryogenesis_phenotype2.00931012
25MP0001672_abnormal_embryogenesis/_devel2.00931012
26MP0004233_abnormal_muscle_weight1.96248419
27MP0003283_abnormal_digestive_organ1.95753201
28MP0004133_heterotaxia1.94470560
29MP0003693_abnormal_embryo_hatching1.89255631
30MP0003123_paternal_imprinting1.88788139
31MP0003786_premature_aging1.86652462
32MP0002086_abnormal_extraembryonic_tissu1.86581008
33MP0000350_abnormal_cell_proliferation1.86135550
34MP0001661_extended_life_span1.84171316
35MP0000534_abnormal_ureter_morphology1.83864501
36MP0000358_abnormal_cell_content/1.81504013
37MP0003121_genomic_imprinting1.81260978
38MP0002085_abnormal_embryonic_tissue1.78955619
39MP0009379_abnormal_foot_pigmentation1.78021256
40MP0003122_maternal_imprinting1.73854517
41MP0001293_anophthalmia1.70262138
42MP0002084_abnormal_developmental_patter1.67520718
43MP0003984_embryonic_growth_retardation1.67299425
44MP0008058_abnormal_DNA_repair1.66677282
45MP0002088_abnormal_embryonic_growth/wei1.66514228
46MP0004197_abnormal_fetal_growth/weight/1.64156147
47MP0002332_abnormal_exercise_endurance1.63289858
48MP0001730_embryonic_growth_arrest1.62932827
49MP0003119_abnormal_digestive_system1.62058455
50MP0003385_abnormal_body_wall1.61756468
51MP0008789_abnormal_olfactory_epithelium1.61020596
52MP0008932_abnormal_embryonic_tissue1.59604042
53MP0009053_abnormal_anal_canal1.58696829
54MP0005508_abnormal_skeleton_morphology1.56290604
55MP0005257_abnormal_intraocular_pressure1.51623057
56MP0001346_abnormal_lacrimal_gland1.51383287
57MP0005394_taste/olfaction_phenotype1.47358433
58MP0005499_abnormal_olfactory_system1.47358433
59MP0001145_abnormal_male_reproductive1.46463494
60MP0001697_abnormal_embryo_size1.46033061
61MP0003115_abnormal_respiratory_system1.37823243
62MP0002249_abnormal_larynx_morphology1.36857567
63MP0005248_abnormal_Harderian_gland1.33566902
64MP0000762_abnormal_tongue_morphology1.32142272
65MP0002060_abnormal_skin_morphology1.30836578
66MP0003938_abnormal_ear_development1.30553361
67MP0002210_abnormal_sex_determination1.30081153
68MP0003136_yellow_coat_color1.27648334
69MP0000759_abnormal_skeletal_muscle1.27219622
70MP0002938_white_spotting1.26641057
71MP0003806_abnormal_nucleotide_metabolis1.26343683
72MP0002932_abnormal_joint_morphology1.24770981
73MP0005266_abnormal_metabolism1.24478371
74MP0002092_abnormal_eye_morphology1.22449978
75MP0002127_abnormal_cardiovascular_syste1.21567241
76MP0009250_abnormal_appendicular_skeleto1.21317166
77MP0003755_abnormal_palate_morphology1.19587275
78MP0004858_abnormal_nervous_system1.18572939
79MP0002080_prenatal_lethality1.17571827
80MP0001299_abnormal_eye_distance/1.17415066
81MP0001929_abnormal_gametogenesis1.16712587
82MP0000049_abnormal_middle_ear1.16092915
83MP0009697_abnormal_copulation1.15965391
84MP0005501_abnormal_skin_physiology1.15958714
85MP0000490_abnormal_crypts_of1.14719398
86MP0000003_abnormal_adipose_tissue1.13242596
87MP0004185_abnormal_adipocyte_glucose1.13179499
88MP0001849_ear_inflammation1.12630781
89MP0001186_pigmentation_phenotype1.11546985
90MP0002075_abnormal_coat/hair_pigmentati1.08710888
91MP0004381_abnormal_hair_follicle1.08253070
92MP0000313_abnormal_cell_death1.08022437
93MP0002896_abnormal_bone_mineralization1.06248157
94MP0008995_early_reproductive_senescence1.05801151
95MP0003942_abnormal_urinary_system1.05601445
96MP0005197_abnormal_uvea_morphology1.05133963
97MP0005058_abnormal_lysosome_morphology1.04225817
98MP0000432_abnormal_head_morphology1.02922914
99MP0008007_abnormal_cellular_replicative1.02188009
100MP0002114_abnormal_axial_skeleton1.02128497
101MP0003935_abnormal_craniofacial_develop1.01933742
102MP0003566_abnormal_cell_adhesion1.01105589
103MP0004272_abnormal_basement_membrane1.00918134
104MP0000653_abnormal_sex_gland1.00756013
105MP0000613_abnormal_salivary_gland1.00274888
106MP0008260_abnormal_autophagy1.00095997
107MP0001348_abnormal_lacrimal_gland0.99760641
108MP0004808_abnormal_hematopoietic_stem0.99576665
109MP0000858_altered_metastatic_potential0.98195385
110MP0006035_abnormal_mitochondrial_morpho0.98013612
111MP0005076_abnormal_cell_differentiation0.96499614
112MP0003698_abnormal_male_reproductive0.95586698
113MP0005409_darkened_coat_color0.94251732
114MP0003941_abnormal_skin_development0.93704761
115MP0003221_abnormal_cardiomyocyte_apopto0.93543051
116MP0000747_muscle_weakness0.93208670
117MP0002113_abnormal_skeleton_development0.91467666
118MP0009278_abnormal_bone_marrow0.91311032
119MP0005391_vision/eye_phenotype0.90038123
120MP0000537_abnormal_urethra_morphology0.89344858
121MP0002396_abnormal_hematopoietic_system0.88831124
122MP0003091_abnormal_cell_migration0.87594908
123MP0002796_impaired_skin_barrier0.87332023
124MP0003137_abnormal_impulse_conducting0.86671541
125MP0005384_cellular_phenotype0.86203729
126MP0002269_muscular_atrophy0.84028375
127MP0000750_abnormal_muscle_regeneration0.83894550
128MP0009703_decreased_birth_body0.83407278
129MP0001270_distended_abdomen0.82743514
130MP0003787_abnormal_imprinting0.80950438
131MP0005621_abnormal_cell_physiology0.80904082
132MP0000015_abnormal_ear_pigmentation0.79993990
133MP0002095_abnormal_skin_pigmentation0.78939162
134MP0009672_abnormal_birth_weight0.78408415
135MP0000678_abnormal_parathyroid_gland0.77978268
136MP0006072_abnormal_retinal_apoptosis0.77536987
137MP0003861_abnormal_nervous_system0.77451910
138MP0002111_abnormal_tail_morphology0.77230037
139MP0005171_absent_coat_pigmentation0.75475412
140MP0000647_abnormal_sebaceous_gland0.74806536
141MP0002019_abnormal_tumor_incidence0.74102720
142MP0002925_abnormal_cardiovascular_devel0.73689608
143MP0010307_abnormal_tumor_latency0.72948287
144MP0008961_abnormal_basal_metabolism0.72893670
145MP0002116_abnormal_craniofacial_bone0.72532670
146MP0002233_abnormal_nose_morphology0.71270922
147MP0000428_abnormal_craniofacial_morphol0.71142027
148MP0005023_abnormal_wound_healing0.70852807
149MP0008770_decreased_survivor_rate0.69845402
150MP0002277_abnormal_respiratory_mucosa0.69208160
151MP0003315_abnormal_perineum_morphology0.68596420
152MP0001286_abnormal_eye_development0.66816100
153MP0002970_abnormal_white_adipose0.66214212
154MP0002161_abnormal_fertility/fecundity0.65323103
155MP0003453_abnormal_keratinocyte_physiol0.64177418
156MP0003567_abnormal_fetal_cardiomyocyte0.63484465

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)5.88504659
2Spinal cord lesions (HP:0100561)5.35313138
3Syringomyelia (HP:0003396)5.35313138
4Rib fusion (HP:0000902)5.33220437
5Vertebral compression fractures (HP:0002953)5.09958831
6Ependymoma (HP:0002888)4.87149454
7Bilateral microphthalmos (HP:0007633)4.59278921
8Abnormality of the distal phalanges of the toes (HP:0010182)4.46381288
9Abnormality of the lower motor neuron (HP:0002366)4.45381819
10Premature rupture of membranes (HP:0001788)4.03753046
11Patchy hypopigmentation of hair (HP:0011365)3.74404204
12White forelock (HP:0002211)3.74186543
13Astrocytoma (HP:0009592)3.73969269
14Abnormality of the astrocytes (HP:0100707)3.73969269
15Nephroblastoma (Wilms tumor) (HP:0002667)3.73864347
16Aplasia/hypoplasia of the humerus (HP:0006507)3.72696201
17Rhabdomyosarcoma (HP:0002859)3.70849955
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.70070075
19Rectal fistula (HP:0100590)3.61498323
20Rectovaginal fistula (HP:0000143)3.61498323
21Short humerus (HP:0005792)3.59427083
22Shawl scrotum (HP:0000049)3.58289966
23Multiple enchondromatosis (HP:0005701)3.56688385
24Entropion (HP:0000621)3.54620434
25Spastic paraparesis (HP:0002313)3.53661578
26Hepatoblastoma (HP:0002884)3.52960584
27Neoplasm of striated muscle (HP:0009728)3.44644592
28Embryonal renal neoplasm (HP:0011794)3.43781345
29Chromsome breakage (HP:0040012)3.34528389
30Abnormality of the ileum (HP:0001549)3.31386927
31Abnormality of the labia minora (HP:0012880)3.29665165
32Abnormality of the salivary glands (HP:0010286)3.28570989
33Meckel diverticulum (HP:0002245)3.20616965
34Intestinal fistula (HP:0100819)3.16909334
35Tongue fasciculations (HP:0001308)3.10339705
36Pendular nystagmus (HP:0012043)3.09419224
37Supernumerary spleens (HP:0009799)3.08059645
38Vaginal fistula (HP:0004320)3.06126346
39Hypopigmentation of the fundus (HP:0007894)3.05038561
40Short nail (HP:0001799)3.00500679
41Missing ribs (HP:0000921)2.93786817
42Neoplasm of the oral cavity (HP:0100649)2.92348351
43Calcaneovalgus deformity (HP:0001848)2.91123465
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.90826915
45Glioma (HP:0009733)2.87828151
46Protrusio acetabuli (HP:0003179)2.86716786
47Cerebral hypomyelination (HP:0006808)2.85316494
48Horizontal nystagmus (HP:0000666)2.82632126
49Limb-girdle muscle atrophy (HP:0003797)2.82001668
50Medulloblastoma (HP:0002885)2.81659381
51Osteolytic defects of the hand bones (HP:0009699)2.80810112
52Osteolytic defects of the phalanges of the hand (HP:0009771)2.80810112
53Muscle fibrillation (HP:0010546)2.78553532
54Impulsivity (HP:0100710)2.67691192
55Achilles tendon contracture (HP:0001771)2.66561380
56Distal lower limb amyotrophy (HP:0008944)2.64758482
57Distal upper limb amyotrophy (HP:0007149)2.61949197
58Upper limb amyotrophy (HP:0009129)2.61949197
59Cutaneous melanoma (HP:0012056)2.59356959
60Renal duplication (HP:0000075)2.57971890
61Paraparesis (HP:0002385)2.57798513
62Abnormality of the umbilical cord (HP:0010881)2.57688866
63Fused cervical vertebrae (HP:0002949)2.57531789
64Absent radius (HP:0003974)2.56656739
65Progressive external ophthalmoplegia (HP:0000590)2.51266819
66Difficulty climbing stairs (HP:0003551)2.50699679
67Selective tooth agenesis (HP:0001592)2.46932132
68Elbow flexion contracture (HP:0002987)2.44843507
69Orthostatic hypotension (HP:0001278)2.43945105
70Trismus (HP:0000211)2.39857753
71Amyotrophic lateral sclerosis (HP:0007354)2.39830053
72Absent forearm bone (HP:0003953)2.39523402
73Aplasia involving forearm bones (HP:0009822)2.39523402
74Testicular atrophy (HP:0000029)2.38403484
75Deformed tarsal bones (HP:0008119)2.38369885
76Lip pit (HP:0100267)2.37475800
77Abnormal lung lobation (HP:0002101)2.36058688
78Concave nail (HP:0001598)2.35301291
79Small intestinal stenosis (HP:0012848)2.34882306
80Duodenal stenosis (HP:0100867)2.34882306
81Annular pancreas (HP:0001734)2.33997743
82Hypochromic anemia (HP:0001931)2.33968895
83Abnormal auditory evoked potentials (HP:0006958)2.31296861
84Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.31118263
85Distal lower limb muscle weakness (HP:0009053)2.31066707
86Volvulus (HP:0002580)2.29928679
87Spinal muscular atrophy (HP:0007269)2.28301851
88Vertebral fusion (HP:0002948)2.27230257
89Deep palmar crease (HP:0006191)2.25248792
90Abnormality of abdominal situs (HP:0011620)2.25218650
91Abdominal situs inversus (HP:0003363)2.25218650
92Abnormality of the preputium (HP:0100587)2.24416585
93Abnormality of the Achilles tendon (HP:0005109)2.23032827
94Premature graying of hair (HP:0002216)2.22530962
95Abnormal umbilical cord blood vessels (HP:0011403)2.22507933
96Single umbilical artery (HP:0001195)2.22507933
97Abnormality of the fetal cardiovascular system (HP:0010948)2.22507933
98Abnormality of cells of the erythroid lineage (HP:0012130)2.21212756
99Pseudobulbar signs (HP:0002200)2.19553574
100Shoulder girdle muscle weakness (HP:0003547)2.18204548
101Asymmetry of the thorax (HP:0001555)2.18097718
102Spinal cord compression (HP:0002176)2.17659872
103Back pain (HP:0003418)2.17291445
104Aplasia/Hypoplasia of the sacrum (HP:0008517)2.16782605
105Multiple lipomas (HP:0001012)2.16460626
106Long palpebral fissure (HP:0000637)2.14867529
107Abnormality of chromosome stability (HP:0003220)2.14666525
108Facial hemangioma (HP:0000329)2.12798744
109Flat acetabular roof (HP:0003180)2.11009953
110Blue irides (HP:0000635)2.09859004
111Small epiphyses (HP:0010585)2.09714255
112Fragile skin (HP:0001030)2.09378029
113Breast hypoplasia (HP:0003187)2.08648278
114Patellar aplasia (HP:0006443)2.08503725
115Short 5th finger (HP:0009237)2.07791526
116Ulnar bowing (HP:0003031)2.06557025
117Delayed cranial suture closure (HP:0000270)2.05943990
118Fatigue (HP:0012378)2.04921391
119Pelvic girdle muscle weakness (HP:0003749)2.04430731
120Broad alveolar ridges (HP:0000187)2.03972101
121Supernumerary ribs (HP:0005815)2.03970823
122Peripheral hypomyelination (HP:0007182)2.03508917
123Large earlobe (HP:0009748)2.02550054
124Increased connective tissue (HP:0009025)2.01337551
125Heterochromia iridis (HP:0001100)2.01134327
126Poikiloderma (HP:0001029)1.99945986
127Abnormality of the distal phalanx of the thumb (HP:0009617)1.98889637
128Abnormality of the duodenum (HP:0002246)1.98405582
129Broad distal phalanx of finger (HP:0009836)1.98212531
130Atrioventricular block (HP:0001678)1.97264935
131Partial duplication of thumb phalanx (HP:0009944)1.96541817
132Spinal rigidity (HP:0003306)1.96494284
133Absent thumb (HP:0009777)1.96214792
134Hemivertebrae (HP:0002937)1.96161719
135Reduced subcutaneous adipose tissue (HP:0003758)1.95652173
136Partial duplication of the phalanx of hand (HP:0009999)1.94884208
137Metaphyseal cupping (HP:0003021)1.93649098
138Rough bone trabeculation (HP:0100670)1.92055617
139Coxa vara (HP:0002812)1.92009962
140Ankyloglossia (HP:0010296)1.91060151
141Premature ovarian failure (HP:0008209)1.90495728
142Abnormality of chromosome segregation (HP:0002916)1.89469771
143Preauricular skin tag (HP:0000384)1.89321275
144Myelodysplasia (HP:0002863)1.89097594
145Bifid tongue (HP:0010297)1.89066712
146Abnormality of the calcaneus (HP:0008364)1.88937049
147Abnormal hemoglobin (HP:0011902)1.88514989
148Preaxial foot polydactyly (HP:0001841)1.88180316
149Aplasia/Hypoplasia of the sternum (HP:0006714)1.87979926
150High anterior hairline (HP:0009890)1.87240080
151Long toe (HP:0010511)1.86003537
152Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.85920313
153Hand muscle atrophy (HP:0009130)1.85837149
154Abnormality of the musculature of the hand (HP:0001421)1.85187143
155Embryonal neoplasm (HP:0002898)1.85133101
156Neoplasm of the peripheral nervous system (HP:0100007)1.84968487
157CNS hypomyelination (HP:0003429)1.84496287
158Supernumerary bones of the axial skeleton (HP:0009144)1.84351882
159Aplasia/Hypoplasia of the patella (HP:0006498)1.84037682
160Alacrima (HP:0000522)1.82676910
161Sparse lateral eyebrow (HP:0005338)1.82641288
162Ankle contracture (HP:0006466)1.82557533
163Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.82437736
164Vertebral clefting (HP:0008428)1.81185876
165Deviation of the thumb (HP:0009603)1.79825660
166Natal tooth (HP:0000695)1.79088635
167Down-sloping shoulders (HP:0200021)1.77937883
168Hyperparathyroidism (HP:0000843)1.77648338
169Fasciculations (HP:0002380)1.77620764
170Abnormality of the phalanges of the hallux (HP:0010057)1.77617934
171Abnormal autonomic nervous system physiology (HP:0012332)1.76720417
172Insidious onset (HP:0003587)1.76612148
173Termporal pattern (HP:0011008)1.76612148
174Agnosia (HP:0010524)1.76195693
175Carpal bone hypoplasia (HP:0001498)1.75997556
176Cubitus valgus (HP:0002967)1.75436541
177Upper limb muscle weakness (HP:0003484)1.75269408
178Dislocated radial head (HP:0003083)1.75130314
179Bladder diverticulum (HP:0000015)1.74369453
180Proximal placement of thumb (HP:0009623)1.74143673
181Reticulocytopenia (HP:0001896)1.72708899
182Distal sensory impairment (HP:0002936)1.72498816
183Flattened epiphyses (HP:0003071)1.72430645
184Abnormality of oral frenula (HP:0000190)1.71318244
185Abnormality of the pulmonary veins (HP:0011718)1.70863424
186Sloping forehead (HP:0000340)1.70577964
187Biconcave vertebral bodies (HP:0004586)1.69726480
188Dysmetric saccades (HP:0000641)1.68876496
189Aplasia/Hypoplasia of the breasts (HP:0010311)1.67083010
190Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.66682997
191Abnormalities of placenta or umbilical cord (HP:0001194)1.65435520

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.30555216
2IRAK34.01643023
3NME23.76557487
4TYRO33.34222231
5LMTK23.23485661
6MATK3.07545548
7TTK2.93233937
8CDC72.73595277
9ICK2.71287405
10GRK52.70298996
11TRIB32.56108591
12SCYL22.51132129
13CDK72.41783279
14GRK62.30534730
15ERBB42.26017826
16DDR22.20783952
17EEF2K2.13019862
18ERN12.07691310
19PAK62.03776324
20AKT31.99058419
21ERBB31.95131560
22PLK11.91129327
23ADRBK21.88292629
24NEK21.88202280
25WEE11.87342941
26EIF2AK31.84384770
27EPHA21.83549787
28EIF2AK11.82717224
29PBK1.77065082
30FLT31.70241733
31GRK11.59308164
32STK101.54940369
33PRKD31.53574746
34CHEK21.52936112
35TSSK61.52109983
36IRAK21.41859188
37CSF1R1.40777006
38ARAF1.39590712
39BUB11.37412282
40MAPK71.35529656
41RPS6KB21.32202752
42CSK1.30612576
43ACVR1B1.29285016
44FGR1.22500781
45KSR21.21624174
46PDGFRA1.21131309
47NEK11.19115517
48MAP3K61.18700078
49ILK1.18449409
50MAP3K101.17653779
51PDK31.17428791
52PDK41.17428791
53UHMK11.17209173
54GRK71.16230755
55BMX1.16005712
56PAK41.15420943
57WNK11.13791728
58CHEK11.12159324
59SIK11.09109313
60SIK31.07173485
61LATS21.06968219
62NTRK11.06694354
63TGFBR21.05654989
64ALK1.03172322
65LATS11.02957140
66EPHB10.99816177
67BRAF0.94501173
68ATR0.90273445
69PDK20.90062056
70CDK40.89254366
71PNCK0.89057171
72MTOR0.88410500
73CDK20.87948021
74MOS0.87783639
75IRAK40.86121304
76MAPK150.83447441
77MARK20.82937005
78MAP2K70.80571669
79AURKB0.80218040
80SMG10.80185133
81ATM0.80168997
82KSR10.79784859
83CAMK40.79062129
84CDK90.78235672
85MET0.76502141
86BMPR20.73629995
87SRPK10.73440700
88AURKA0.71049276
89PRKG20.70337961
90PDGFRB0.70095450
91PRKD20.69712534
92ADRBK10.68974125
93BRD40.66764108
94MAP3K30.66463315
95DAPK10.66331763
96MAP3K80.65042405
97TRPM70.64194686
98LRRK20.64060854
99DYRK30.63972115
100BRSK10.63582295
101PRPF4B0.63450351
102TTN0.62153754
103GSK3A0.62093285
104PRKCI0.59301100
105TESK20.59042692
106PAK20.58885262
107PHKG20.58082899
108PHKG10.58082899
109CDK10.57760194
110PASK0.57190734
111IRAK10.54221959
112CSNK1E0.53537013
113CDC42BPA0.50888834
114NEK90.49626200
115YES10.49034687
116MAPKAPK30.48684574
117STK160.48078882
118PAK10.47045840
119AKT20.46888778
120MAP3K130.46164391
121MAPK100.45348961
122ZAP700.44768373
123TGFBR10.44738760
124CDK60.43759612
125CDK180.43635557
126MAP3K110.42906796
127MARK30.42800026
128RAF10.41001675
129MAPK140.40775789
130MAPK10.40509882
131INSR0.40311215
132MAP3K20.39387487
133TESK10.39354672
134GSK3B0.38566104
135CDK80.38530674
136EIF2AK20.38015941
137MAP2K30.37881921
138CDK140.36479326
139DYRK1B0.36253084
140TAOK20.36059217
141PTK20.34396677
142CSNK1D0.34077874
143STK380.34067646
144RIPK10.33903543
145MKNK20.33580134
146CSNK2A20.32535583
147CDK150.32224086
148PAK30.31658352
149MAP3K90.31550873
150CDK11A0.31329449
151MAP2K40.31238882
152HIPK20.31226529
153PIM10.31167246
154MKNK10.30864013

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.61880903
2Mismatch repair_Homo sapiens_hsa034304.37129808
3DNA replication_Homo sapiens_hsa030303.81900065
4RNA transport_Homo sapiens_hsa030133.06667822
5Fanconi anemia pathway_Homo sapiens_hsa034603.00918703
6Homologous recombination_Homo sapiens_hsa034402.89303749
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.87264072
8Vitamin B6 metabolism_Homo sapiens_hsa007502.78292548
9Spliceosome_Homo sapiens_hsa030402.66107002
10Base excision repair_Homo sapiens_hsa034102.60715345
11Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.55429034
12mRNA surveillance pathway_Homo sapiens_hsa030152.54372483
13Cell cycle_Homo sapiens_hsa041102.40189017
14Nucleotide excision repair_Homo sapiens_hsa034202.09617087
15Fructose and mannose metabolism_Homo sapiens_hsa000512.08742764
16One carbon pool by folate_Homo sapiens_hsa006702.00621203
17Ribosome_Homo sapiens_hsa030101.97454767
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90560069
19N-Glycan biosynthesis_Homo sapiens_hsa005101.90221492
20Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.80539022
21Chronic myeloid leukemia_Homo sapiens_hsa052201.75409013
22Pancreatic cancer_Homo sapiens_hsa052121.71138867
23p53 signaling pathway_Homo sapiens_hsa041151.65141159
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.61593160
25Basal transcription factors_Homo sapiens_hsa030221.58320865
26Prion diseases_Homo sapiens_hsa050201.57929596
27mTOR signaling pathway_Homo sapiens_hsa041501.54180285
28Sulfur metabolism_Homo sapiens_hsa009201.54056868
29Proteasome_Homo sapiens_hsa030501.51514850
30Hippo signaling pathway_Homo sapiens_hsa043901.50014963
31Fatty acid biosynthesis_Homo sapiens_hsa000611.47667555
32RNA degradation_Homo sapiens_hsa030181.47299123
33Non-small cell lung cancer_Homo sapiens_hsa052231.43004325
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.39568026
35Non-homologous end-joining_Homo sapiens_hsa034501.35964294
36Galactose metabolism_Homo sapiens_hsa000521.34222205
37Renal cell carcinoma_Homo sapiens_hsa052111.33949074
38Hedgehog signaling pathway_Homo sapiens_hsa043401.30436268
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25895309
40Oocyte meiosis_Homo sapiens_hsa041141.25062729
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24329662
42Arachidonic acid metabolism_Homo sapiens_hsa005901.21869350
43ErbB signaling pathway_Homo sapiens_hsa040121.20667419
44Linoleic acid metabolism_Homo sapiens_hsa005911.19922280
45Basal cell carcinoma_Homo sapiens_hsa052171.17990313
46Glioma_Homo sapiens_hsa052141.14944077
47Biosynthesis of amino acids_Homo sapiens_hsa012301.12378252
48Notch signaling pathway_Homo sapiens_hsa043301.11710285
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07853222
50Endometrial cancer_Homo sapiens_hsa052131.04477591
51Thyroid cancer_Homo sapiens_hsa052161.04334019
52MicroRNAs in cancer_Homo sapiens_hsa052061.02955584
53Prostate cancer_Homo sapiens_hsa052151.02148179
54RNA polymerase_Homo sapiens_hsa030201.00631468
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99587167
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99234700
57Insulin signaling pathway_Homo sapiens_hsa049100.98435533
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97452618
59Dorso-ventral axis formation_Homo sapiens_hsa043200.96095892
60Lysine degradation_Homo sapiens_hsa003100.95165614
61Folate biosynthesis_Homo sapiens_hsa007900.94893333
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93453308
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93001757
64ECM-receptor interaction_Homo sapiens_hsa045120.91227349
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91111136
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89499595
67TGF-beta signaling pathway_Homo sapiens_hsa043500.87926944
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.87919932
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86261491
70Adherens junction_Homo sapiens_hsa045200.85850406
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84991476
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84385483
73Tight junction_Homo sapiens_hsa045300.84296932
74Wnt signaling pathway_Homo sapiens_hsa043100.83361008
75Apoptosis_Homo sapiens_hsa042100.78481441
76Purine metabolism_Homo sapiens_hsa002300.76750617
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.74232696
78Melanoma_Homo sapiens_hsa052180.72359214
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70981213
80Focal adhesion_Homo sapiens_hsa045100.70729128
81Hepatitis B_Homo sapiens_hsa051610.70172896
82Selenocompound metabolism_Homo sapiens_hsa004500.69834447
83Pathways in cancer_Homo sapiens_hsa052000.68593838
84Pyrimidine metabolism_Homo sapiens_hsa002400.65747026
85Bladder cancer_Homo sapiens_hsa052190.63343186
86Colorectal cancer_Homo sapiens_hsa052100.63040344
87Herpes simplex infection_Homo sapiens_hsa051680.62633327
88FoxO signaling pathway_Homo sapiens_hsa040680.61166613
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59504332
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.59353753
91Alcoholism_Homo sapiens_hsa050340.57928106
92Vibrio cholerae infection_Homo sapiens_hsa051100.54592776
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.53601722
94Melanogenesis_Homo sapiens_hsa049160.51733759
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50060144
96Small cell lung cancer_Homo sapiens_hsa052220.49258849
97Shigellosis_Homo sapiens_hsa051310.48555645
98Choline metabolism in cancer_Homo sapiens_hsa052310.47466450
99HTLV-I infection_Homo sapiens_hsa051660.46684365
100Endocytosis_Homo sapiens_hsa041440.44100369
101Pentose phosphate pathway_Homo sapiens_hsa000300.43463323
102Prolactin signaling pathway_Homo sapiens_hsa049170.42064920
103Arginine and proline metabolism_Homo sapiens_hsa003300.41994555
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41275395
105Sulfur relay system_Homo sapiens_hsa041220.41043920
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40617940
107Viral carcinogenesis_Homo sapiens_hsa052030.40367513
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40239569
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38094598
110Estrogen signaling pathway_Homo sapiens_hsa049150.37452297
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37060555
112Carbon metabolism_Homo sapiens_hsa012000.35861458
113Proteoglycans in cancer_Homo sapiens_hsa052050.33127417
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.31762251
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31223095
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31184605
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30973921
118Rap1 signaling pathway_Homo sapiens_hsa040150.30630767
119AMPK signaling pathway_Homo sapiens_hsa041520.30408757
120VEGF signaling pathway_Homo sapiens_hsa043700.29316219
121Ether lipid metabolism_Homo sapiens_hsa005650.28177793
122Inositol phosphate metabolism_Homo sapiens_hsa005620.28056566
123Glutathione metabolism_Homo sapiens_hsa004800.27926907
124Autoimmune thyroid disease_Homo sapiens_hsa053200.26254022
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.23120743
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22461843
127Ovarian steroidogenesis_Homo sapiens_hsa049130.20512795
128Regulation of autophagy_Homo sapiens_hsa041400.19615755
129Chemical carcinogenesis_Homo sapiens_hsa052040.17078178
130Gap junction_Homo sapiens_hsa045400.17050788
131Glycerolipid metabolism_Homo sapiens_hsa005610.15240720
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.14359526
133Epstein-Barr virus infection_Homo sapiens_hsa051690.13488260
134Arginine biosynthesis_Homo sapiens_hsa002200.13487584
135RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.12983484
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12899512
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.12166033
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.11195387
139Acute myeloid leukemia_Homo sapiens_hsa052210.10950150

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