MAGEA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis (GO:0007140)9.99932181
2regulation of meiosis I (GO:0060631)9.98485006
3meiotic nuclear division (GO:0007126)9.39090186
4chromosome organization involved in meiosis (GO:0070192)8.99568456
5positive regulation of translational initiation (GO:0045948)8.95932207
6male meiosis I (GO:0007141)8.87217841
7positive regulation of meiosis (GO:0045836)7.79869866
8meiosis I (GO:0007127)7.42097269
9positive regulation of meiotic cell cycle (GO:0051446)7.24874492
10negative regulation of protein acetylation (GO:1901984)6.44726897
11meiotic cell cycle process (GO:1903046)6.41035148
12DNA alkylation (GO:0006305)6.38101951
13DNA methylation (GO:0006306)6.38101951
14protein-cofactor linkage (GO:0018065)6.31115406
15oocyte maturation (GO:0001556)6.30528501
16cellular protein catabolic process (GO:0044257)6.13967688
17gene silencing by RNA (GO:0031047)6.10802836
18DNA synthesis involved in DNA repair (GO:0000731)5.74033612
19regulation of translational fidelity (GO:0006450)5.72122006
20reciprocal DNA recombination (GO:0035825)5.57660678
21reciprocal meiotic recombination (GO:0007131)5.57660678
22oogenesis (GO:0048477)5.36351041
23DNA methylation or demethylation (GO:0044728)5.03704371
24COPI coating of Golgi vesicle (GO:0048205)4.93305881
25Golgi transport vesicle coating (GO:0048200)4.93305881
26negative regulation of meiosis (GO:0045835)4.91325806
27DNA replication checkpoint (GO:0000076)4.86864986
28formation of translation preinitiation complex (GO:0001731)4.73683915
29mitotic chromosome condensation (GO:0007076)4.71020182
30ribosome assembly (GO:0042255)4.68355569
31regulation of meiosis (GO:0040020)4.65411367
32homocysteine metabolic process (GO:0050667)4.64323040
33gonadal mesoderm development (GO:0007506)4.47345469
34synapsis (GO:0007129)4.45263165
35regulation of protein sumoylation (GO:0033233)4.37094549
36DNA unwinding involved in DNA replication (GO:0006268)4.29593964
37DNA strand renaturation (GO:0000733)4.19899695
38regulation of double-strand break repair via homologous recombination (GO:0010569)4.17101107
39DNA modification (GO:0006304)4.06769021
40nucleobase-containing small molecule interconversion (GO:0015949)4.06322359
41mitotic sister chromatid segregation (GO:0000070)4.05240359
42mitotic nuclear envelope disassembly (GO:0007077)4.04387720
43blastocyst development (GO:0001824)3.99117218
44meiotic cell cycle (GO:0051321)3.95077820
45regulation of meiotic cell cycle (GO:0051445)3.93776450
46DNA strand elongation involved in DNA replication (GO:0006271)3.93748703
47proline biosynthetic process (GO:0006561)3.89708122
48gene silencing (GO:0016458)3.85190337
49ribosomal small subunit biogenesis (GO:0042274)3.84535971
50regulation of protein polyubiquitination (GO:1902914)3.83860439
51DNA strand elongation (GO:0022616)3.82851757
52ribosome biogenesis (GO:0042254)3.79806235
53DNA replication initiation (GO:0006270)3.77994559
54nuclear pore complex assembly (GO:0051292)3.77411149
55sister chromatid segregation (GO:0000819)3.77327531
56tRNA aminoacylation for protein translation (GO:0006418)3.76718529
57ribonucleoprotein complex biogenesis (GO:0022613)3.75961123
58membrane disassembly (GO:0030397)3.74594756
59nuclear envelope disassembly (GO:0051081)3.74594756
60regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.73758496
61nuclear pore organization (GO:0006999)3.73281579
62midgut development (GO:0007494)3.70856771
63heterochromatin organization (GO:0070828)3.67305550
64regulation of mitotic spindle organization (GO:0060236)3.64226686
65amino acid activation (GO:0043038)3.61588087
66tRNA aminoacylation (GO:0043039)3.61588087
67telomere maintenance via semi-conservative replication (GO:0032201)3.57537953
68folic acid metabolic process (GO:0046655)3.54327526
69negative regulation of neurotransmitter secretion (GO:0046929)3.44635148
70regulation of translational elongation (GO:0006448)3.42318848
71folic acid-containing compound biosynthetic process (GO:0009396)3.35443839
72mitotic metaphase plate congression (GO:0007080)3.32300181
73female gamete generation (GO:0007292)3.31184118
74cellular senescence (GO:0090398)3.27274066
75peptidyl-lysine dimethylation (GO:0018027)3.26777750
76regulation of RIG-I signaling pathway (GO:0039535)3.26348964
77regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.22926381
78regulation of hexokinase activity (GO:1903299)3.21979740
79regulation of glucokinase activity (GO:0033131)3.21979740
80germ cell development (GO:0007281)3.19673057
81protein K6-linked ubiquitination (GO:0085020)3.18857807
82positive regulation of lymphocyte apoptotic process (GO:0070230)3.18507401
83histone H3-K9 methylation (GO:0051567)3.18386195
84L-serine metabolic process (GO:0006563)3.18126338
85regulation of RNA export from nucleus (GO:0046831)3.18066158
86protein neddylation (GO:0045116)3.17378695
87meiotic chromosome segregation (GO:0045132)3.17040211
88intra-S DNA damage checkpoint (GO:0031573)3.16178142
89negative regulation of DNA recombination (GO:0045910)3.14587907
90negative regulation of meiotic cell cycle (GO:0051447)3.13871734
91spermatogenesis (GO:0007283)3.13691882
92chromosome condensation (GO:0030261)3.13503606
93protein localization to chromosome, centromeric region (GO:0071459)3.12961842
94male gamete generation (GO:0048232)3.12751604
95viral transcription (GO:0019083)3.11384243
96translational initiation (GO:0006413)3.08103708
97negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.07329443
98sister chromatid cohesion (GO:0007062)3.07127392
99nuclear envelope organization (GO:0006998)3.06670192
100translational termination (GO:0006415)3.05762357
101attachment of spindle microtubules to kinetochore (GO:0008608)3.04590399
102folic acid-containing compound metabolic process (GO:0006760)3.04519151
103ribosomal small subunit assembly (GO:0000028)3.03558983
104protein export from nucleus (GO:0006611)3.03254337
105iron ion import (GO:0097286)3.02763250
106urea cycle (GO:0000050)3.02654385
107telomere maintenance via recombination (GO:0000722)2.96452685
108regulation of spindle organization (GO:0090224)2.96384820
109oocyte development (GO:0048599)2.94798451
110IMP biosynthetic process (GO:0006188)2.94438654
111mitotic sister chromatid cohesion (GO:0007064)2.93715507
112nucleobase biosynthetic process (GO:0046112)2.93525478
113DNA replication-dependent nucleosome organization (GO:0034723)2.91701805
114DNA replication-dependent nucleosome assembly (GO:0006335)2.91701805
115nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.91325122
116oxidative phosphorylation (GO:0006119)2.91150938
117regulation of histone H3-K27 methylation (GO:0061085)2.89918997
118cellular protein complex localization (GO:0034629)2.89527082
119SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.88992109
120protein complex localization (GO:0031503)2.88709136
121pore complex assembly (GO:0046931)2.88511220
122tricarboxylic acid cycle (GO:0006099)2.87842702
123protein localization to kinetochore (GO:0034501)2.87334975
124retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.86984082
125gamete generation (GO:0007276)2.85862332
126mitotic recombination (GO:0006312)2.84538922
127viral protein processing (GO:0019082)2.84318158
128spliceosomal tri-snRNP complex assembly (GO:0000244)2.81965791
129DNA packaging (GO:0006323)2.81824327
130maturation of SSU-rRNA (GO:0030490)2.81755613
131nuclear division (GO:0000280)2.81461780
132regulation of double-strand break repair (GO:2000779)2.80739211
133cotranslational protein targeting to membrane (GO:0006613)2.80005670
134serine family amino acid biosynthetic process (GO:0009070)2.79794780
135establishment of integrated proviral latency (GO:0075713)2.78350107
136protein targeting to ER (GO:0045047)2.78169848
137biotin metabolic process (GO:0006768)2.77359579
138translational elongation (GO:0006414)2.77248085
139urea metabolic process (GO:0019627)2.76458462
140regulation of retinoic acid receptor signaling pathway (GO:0048385)2.76194712
141protoporphyrinogen IX metabolic process (GO:0046501)2.74496859
142regulation of nucleobase-containing compound transport (GO:0032239)2.73466746
143tetrahydrofolate metabolic process (GO:0046653)2.72919509
144regulation of translational termination (GO:0006449)2.72912564
145metaphase plate congression (GO:0051310)2.72899627
146negative regulation of neurotransmitter transport (GO:0051589)2.72677500
147mRNA export from nucleus (GO:0006406)2.71720553
148positive regulation of DNA-dependent DNA replication (GO:2000105)2.71709773
149establishment of protein localization to endoplasmic reticulum (GO:0072599)2.71016757
150pteridine-containing compound metabolic process (GO:0042558)2.70042583
151pteridine-containing compound biosynthetic process (GO:0042559)2.69913416
152NADH metabolic process (GO:0006734)2.69032746
153protein localization to endoplasmic reticulum (GO:0070972)2.68796916
154pentose-phosphate shunt (GO:0006098)2.68228191
155proline metabolic process (GO:0006560)2.67847995
156histone H4-K12 acetylation (GO:0043983)2.67459637
157DNA topological change (GO:0006265)2.67320530
158diterpenoid biosynthetic process (GO:0016102)2.65812904
159resolution of meiotic recombination intermediates (GO:0000712)2.65063123
160tRNA methylation (GO:0030488)2.63445701
161regulation of histone H3-K9 methylation (GO:0051570)2.63044821
162histone H4-K5 acetylation (GO:0043981)2.61965421
163histone H4-K8 acetylation (GO:0043982)2.61965421
164cellular component biogenesis (GO:0044085)2.61757883
165proteasome assembly (GO:0043248)2.60673087
166IMP metabolic process (GO:0046040)2.60578000
167oxaloacetate metabolic process (GO:0006107)2.60208760
168regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.57482181
169organelle fission (GO:0048285)2.54022077
170cullin deneddylation (GO:0010388)2.53766154
171ribosomal large subunit biogenesis (GO:0042273)2.52514866
172negative regulation of histone modification (GO:0031057)2.52306624
173postreplication repair (GO:0006301)2.51463894
174regulation of establishment of cell polarity (GO:2000114)2.46130138
175RNA export from nucleus (GO:0006405)2.44236441
176G1 DNA damage checkpoint (GO:0044783)2.44089916
177histone lysine demethylation (GO:0070076)2.41576548
178positive regulation of translation (GO:0045727)2.40067384
179regulation of gene expression by genetic imprinting (GO:0006349)2.38919378
180Rap protein signal transduction (GO:0032486)2.38805894
181purine nucleobase biosynthetic process (GO:0009113)2.38778757
182mRNA transport (GO:0051028)2.38216476
183negative regulation of chromatin modification (GO:1903309)2.37701732
184regulation of gene silencing by RNA (GO:0060966)2.37631655
185regulation of posttranscriptional gene silencing (GO:0060147)2.37631655
186regulation of gene silencing by miRNA (GO:0060964)2.37631655
187histone H3-K9 modification (GO:0061647)2.37406840
188DNA damage induced protein phosphorylation (GO:0006975)2.36672767
189piRNA metabolic process (GO:0034587)17.2816084
190DNA methylation involved in gamete generation (GO:0043046)14.3607503
191synaptonemal complex assembly (GO:0007130)13.4809320
192synaptonemal complex organization (GO:0070193)12.7673916

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.64899986
2RBPJ_22232070_ChIP-Seq_NCS_Mouse6.70578134
3E2F7_22180533_ChIP-Seq_HELA_Human6.54972650
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse5.82783927
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.65907461
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.31794954
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.21508950
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.27596182
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.97149058
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.97149058
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.97149058
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59007594
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.58381513
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52576356
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.50176527
16RNF2_27304074_Chip-Seq_NSC_Mouse2.43949800
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.41880241
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.29596707
19GATA1_22025678_ChIP-Seq_K562_Human2.24641051
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05957584
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.03221438
22E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94789805
23TTF2_22483619_ChIP-Seq_HELA_Human1.88840444
24PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.80339543
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.78285341
26E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77815415
27AR_21909140_ChIP-Seq_LNCAP_Human1.77237046
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.76672866
29DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.75811515
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.74006716
31FUS_26573619_Chip-Seq_HEK293_Human1.69740775
32KDM5A_27292631_Chip-Seq_BREAST_Human1.69233871
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67501713
34GABP_19822575_ChIP-Seq_HepG2_Human1.65408773
35TP53_16413492_ChIP-PET_HCT116_Human1.65065739
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.64144937
37CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.62750298
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62592131
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.62224352
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62165951
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62099188
42GATA3_21867929_ChIP-Seq_TH1_Mouse1.55387031
43CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.54083511
44MYC_22102868_ChIP-Seq_BL_Human1.52992190
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.51593839
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50669497
47TFEB_21752829_ChIP-Seq_HELA_Human1.48982628
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47806654
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.46744323
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44091110
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42472549
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41972101
53NCOR1_26117541_ChIP-Seq_K562_Human1.41961432
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40890209
55HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.38938285
56GATA1_26923725_Chip-Seq_HPCs_Mouse1.37574326
57CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.36716136
58EST1_17652178_ChIP-ChIP_JURKAT_Human1.36617795
59ELK1_19687146_ChIP-ChIP_HELA_Human1.36038035
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35385059
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35203047
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33333540
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32958937
64CHD1_26751641_Chip-Seq_LNCaP_Human1.30295709
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30016729
66ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.29832230
67HTT_18923047_ChIP-ChIP_STHdh_Human1.28227122
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28197409
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28115529
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.27655566
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26709213
72MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26577177
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24281052
74CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23172863
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22578700
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21683327
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21142408
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.20107880
79NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18668736
80FOXM1_23109430_ChIP-Seq_U2OS_Human1.16386902
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15933095
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15604482
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15029894
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13651798
85RACK7_27058665_Chip-Seq_MCF-7_Human1.13465558
86LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11548220
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11419030
88SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11332435
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11020632
90ATF3_27146783_Chip-Seq_COLON_Human1.09442369
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06620435
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05928412
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05076094
94CIITA_25753668_ChIP-Seq_RAJI_Human1.03294812
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03240723
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03094234
97SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02116382
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01881649
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01076292
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00690911
101CLOCK_20551151_ChIP-Seq_293T_Human1.00670254
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00358579
103EZH2_22144423_ChIP-Seq_EOC_Human0.98822365
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97841559
105TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97177496
106RUNX1_26923725_Chip-Seq_HPCs_Mouse0.96947642
107KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96666576
108SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96487940
109ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95756787
110SALL1_21062744_ChIP-ChIP_HESCs_Human0.95594534
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95366526
112SOX17_20123909_ChIP-Seq_XEN_Mouse0.94504536
113TCF4_23295773_ChIP-Seq_U87_Human0.93343349
114ZNF263_19887448_ChIP-Seq_K562_Human0.92801046
115ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92553231
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92485402
117ERG_21242973_ChIP-ChIP_JURKAT_Human0.91631767
118HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91251616
119REST_19997604_ChIP-ChIP_NEURONS_Mouse0.90206235
120CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89852041
121ELK3_25401928_ChIP-Seq_HUVEC_Human0.89432635
122P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89427652
123* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89380427
124FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88253867
125ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88076783
126KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87819493
127EWS_26573619_Chip-Seq_HEK293_Human0.86921741
128DCP1A_22483619_ChIP-Seq_HELA_Human0.86845945
129POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85818045
130RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85591624
131VDR_23849224_ChIP-Seq_CD4+_Human0.85440656
132CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83707999
133XRN2_22483619_ChIP-Seq_HELA_Human0.82881132
134FOXA1_27270436_Chip-Seq_PROSTATE_Human0.82489009
135FOXA1_25329375_ChIP-Seq_VCAP_Human0.82489009
136WT1_19549856_ChIP-ChIP_CCG9911_Human0.82468649
137TET1_21490601_ChIP-Seq_MESCs_Mouse0.82168626
138NFE2_27457419_Chip-Seq_LIVER_Mouse0.81654710
139POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81376950
140TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.78075091
141CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.77663504
142SOX2_21211035_ChIP-Seq_LN229_Gbm0.74942522
143CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.73797540
144MYC_18358816_ChIP-ChIP_MESCs_Mouse0.73541595
145RNF2_27304074_Chip-Seq_ESCs_Mouse0.73339723
146CDX2_22108803_ChIP-Seq_LS180_Human0.72716122
147PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.71942582
148SUZ12_27294783_Chip-Seq_NPCs_Mouse0.70422828
149LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.67906468
150EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.66549867
151STAT3_18555785_ChIP-Seq_MESCs_Mouse0.66367307
152NANOG_16153702_ChIP-ChIP_HESCs_Human0.64004655
153P300_19829295_ChIP-Seq_ESCs_Human0.63969684
154SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.63515772
155EZH2_27294783_Chip-Seq_NPCs_Mouse0.62920605
156STAT1_17558387_ChIP-Seq_HELA_Human0.62659813
157STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.62608076
158GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.61892749
159MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.60913973
160CBX2_22325352_ChIP-Seq_293T-Rex_Human0.60769002
161PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.60344410
162CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.60248481
163FOXP3_21729870_ChIP-Seq_TREG_Human0.59870013
164SOX9_26525672_Chip-Seq_HEART_Mouse0.59411572

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence5.62313943
2MP0002210_abnormal_sex_determination4.60206248
3MP0003123_paternal_imprinting4.49147471
4MP0001929_abnormal_gametogenesis3.71899325
5MP0001986_abnormal_taste_sensitivity3.70238783
6MP0001145_abnormal_male_reproductive3.67668440
7MP0003786_premature_aging3.58981482
8MP0005451_abnormal_body_composition3.31781889
9MP0000653_abnormal_sex_gland3.26341901
10MP0002877_abnormal_melanocyte_morpholog3.18533654
11MP0003698_abnormal_male_reproductive3.04128983
12MP0004233_abnormal_muscle_weight3.03214880
13MP0008058_abnormal_DNA_repair2.92747600
14MP0002139_abnormal_hepatobiliary_system2.85836345
15MP0003136_yellow_coat_color2.24514124
16MP0005408_hypopigmentation2.21740312
17MP0010094_abnormal_chromosome_stability2.11128463
18MP0003787_abnormal_imprinting2.08043851
19MP0002160_abnormal_reproductive_system2.00743462
20MP0003806_abnormal_nucleotide_metabolis2.00078375
21MP0008877_abnormal_DNA_methylation10.7092735
22MP0010352_gastrointestinal_tract_polyps1.95340369
23MP0004808_abnormal_hematopoietic_stem1.88832842
24MP0004858_abnormal_nervous_system1.85231122
25MP0002161_abnormal_fertility/fecundity1.85201172
26MP0001348_abnormal_lacrimal_gland1.77930441
27MP0003705_abnormal_hypodermis_morpholog1.77375686
28MP0003656_abnormal_erythrocyte_physiolo1.71971601
29MP0003186_abnormal_redox_activity1.70375374
30MP0003121_genomic_imprinting1.70233241
31MP0004147_increased_porphyrin_level1.66120825
32MP0003941_abnormal_skin_development1.65133787
33MP0004270_analgesia1.63153604
34MP0002080_prenatal_lethality1.59529482
35MP0005058_abnormal_lysosome_morphology1.55985605
36MP0004957_abnormal_blastocyst_morpholog1.54466042
37MP0010307_abnormal_tumor_latency1.53946347
38MP0001672_abnormal_embryogenesis/_devel1.52257661
39MP0005380_embryogenesis_phenotype1.52257661
40MP0001697_abnormal_embryo_size1.51959293
41MP0006035_abnormal_mitochondrial_morpho1.49344409
42MP0002735_abnormal_chemical_nociception1.46889516
43MP0003880_abnormal_central_pattern1.46188049
44MP0003111_abnormal_nucleus_morphology1.45488947
45MP0005076_abnormal_cell_differentiation1.44462019
46MP0003693_abnormal_embryo_hatching1.43829587
47MP0003984_embryonic_growth_retardation1.43041678
48MP0000358_abnormal_cell_content/1.40432751
49MP0002088_abnormal_embryonic_growth/wei1.37496210
50MP0006292_abnormal_olfactory_placode1.35665564
51MP0005501_abnormal_skin_physiology1.32173474
52MP0006036_abnormal_mitochondrial_physio1.29451523
53MP0002086_abnormal_extraembryonic_tissu1.29131260
54MP0008007_abnormal_cellular_replicative1.27826487
55MP0001119_abnormal_female_reproductive1.26393785
56MP0008932_abnormal_embryonic_tissue1.25565628
57MP0000678_abnormal_parathyroid_gland1.24858999
58MP0005666_abnormal_adipose_tissue1.24038809
59MP0003718_maternal_effect1.20704417
60MP0000372_irregular_coat_pigmentation1.18406924
61MP0002822_catalepsy1.15613087
62MP0005647_abnormal_sex_gland1.12045554
63MP0003699_abnormal_female_reproductive1.07963535
64MP0000537_abnormal_urethra_morphology1.06861475
65MP0001881_abnormal_mammary_gland1.05692095
66MP0008438_abnormal_cutaneous_collagen1.04942381
67MP0002084_abnormal_developmental_patter1.03273210
68MP0005389_reproductive_system_phenotype1.02250903
69MP0005083_abnormal_biliary_tract1.01065699
70MP0002269_muscular_atrophy0.99309700
71MP0006072_abnormal_retinal_apoptosis0.98919049
72MP0000003_abnormal_adipose_tissue0.97368098
73MP0001661_extended_life_span0.96483386
74MP0010030_abnormal_orbit_morphology0.96225685
75MP0003077_abnormal_cell_cycle0.95456440
76MP0004084_abnormal_cardiac_muscle0.94449944
77MP0004859_abnormal_synaptic_plasticity0.94071838
78MP0001730_embryonic_growth_arrest0.93055815
79MP0003959_abnormal_lean_body0.92392186
80MP0002396_abnormal_hematopoietic_system0.92172460
81MP0002060_abnormal_skin_morphology0.91487664
82MP0005384_cellular_phenotype0.89598860
83MP0001177_atelectasis0.88850095
84MP0009672_abnormal_birth_weight0.87948073
85MP0000627_abnormal_mammary_gland0.87604640
86MP0005330_cardiomyopathy0.86843455
87MP0003221_abnormal_cardiomyocyte_apopto0.86255655
88MP0005621_abnormal_cell_physiology0.85288147
89MP0002734_abnormal_mechanical_nocicepti0.85103983
90MP0009697_abnormal_copulation0.84259291
91MP0003632_abnormal_nervous_system0.82717687
92MP0005377_hearing/vestibular/ear_phenot0.82416789
93MP0003878_abnormal_ear_physiology0.82416789
94MP0003566_abnormal_cell_adhesion0.80860446
95MP0008775_abnormal_heart_ventricle0.80837718
96MP0005623_abnormal_meninges_morphology0.80242906
97MP0000377_abnormal_hair_follicle0.79202592
98MP0001186_pigmentation_phenotype0.78674176
99MP0000747_muscle_weakness0.78226901
100MP0005171_absent_coat_pigmentation0.75504724
101MP0000778_abnormal_nervous_system0.75018158
102MP0001873_stomach_inflammation0.75006129
103MP0005332_abnormal_amino_acid0.73750438
104MP0004264_abnormal_extraembryonic_tissu0.72128511
105MP0001764_abnormal_homeostasis0.70578979
106MP0006138_congestive_heart_failure0.69907765
107MP0009333_abnormal_splenocyte_physiolog0.69682753
108MP0000579_abnormal_nail_morphology0.69135617
109MP0000609_abnormal_liver_physiology0.68335890
110MP0001727_abnormal_embryo_implantation0.67858338
111MP0000490_abnormal_crypts_of0.67509327
112MP0003453_abnormal_keratinocyte_physiol0.67245794
113MP0005187_abnormal_penis_morphology0.66778925
114MP0001915_intracranial_hemorrhage0.66366205
115MP0004036_abnormal_muscle_relaxation0.66314110
116MP0001216_abnormal_epidermal_layer0.66024414
117MP0001486_abnormal_startle_reflex0.64068704
118MP0005360_urolithiasis0.64004805
119MP0004197_abnormal_fetal_growth/weight/0.63938926
120MP0004381_abnormal_hair_follicle0.63195051
121MP0004782_abnormal_surfactant_physiolog0.62475440
122MP0010630_abnormal_cardiac_muscle0.62048713
123MP0004185_abnormal_adipocyte_glucose0.61908666
124MP0005085_abnormal_gallbladder_physiolo0.59240449
125MP0002233_abnormal_nose_morphology0.59217444
126MP0010234_abnormal_vibrissa_follicle0.58712203
127MP0005410_abnormal_fertilization0.57791678
128MP0003936_abnormal_reproductive_system0.57413617
129MP0002063_abnormal_learning/memory/cond0.57361296
130MP0004885_abnormal_endolymph0.56535067
131MP0003635_abnormal_synaptic_transmissio0.54823980
132MP0003045_fibrosis0.54782675
133MP0002184_abnormal_innervation0.53526608
134MP0008875_abnormal_xenobiotic_pharmacok0.53357028
135MP0006276_abnormal_autonomic_nervous0.53112237
136MP0005395_other_phenotype0.52852783
137MP0000955_abnormal_spinal_cord0.52697531
138MP0004484_altered_response_of0.48584756
139MP0008057_abnormal_DNA_replication0.48499349
140MP0002085_abnormal_embryonic_tissue0.47483681
141MP0001542_abnormal_bone_strength0.47343734
142MP0002009_preneoplasia0.46952180
143MP0008961_abnormal_basal_metabolism0.45284599
144MP0002019_abnormal_tumor_incidence0.44077790
145MP0003315_abnormal_perineum_morphology0.43378546
146MP0010329_abnormal_lipoprotein_level0.41805567
147MP0003195_calcinosis0.41153091
148MP0002733_abnormal_thermal_nociception0.40733251
149MP0004215_abnormal_myocardial_fiber0.40504079
150MP0000313_abnormal_cell_death0.39891527
151MP0002796_impaired_skin_barrier0.37912512
152MP0008260_abnormal_autophagy0.37756179
153MP0002572_abnormal_emotion/affect_behav0.37580503
154MP0004142_abnormal_muscle_tone0.36429962
155MP0002876_abnormal_thyroid_physiology0.35255382
156MP0009840_abnormal_foam_cell0.35227031
157MP0001501_abnormal_sleep_pattern0.34745279
158MP0000647_abnormal_sebaceous_gland0.34192778
159MP0000350_abnormal_cell_proliferation0.33922627
160MP0005266_abnormal_metabolism0.32497585
161MP0004043_abnormal_pH_regulation0.31099390
162MP0002971_abnormal_brown_adipose0.29079266

Predicted human phenotypes

RankGene SetZ-score
1Abnormal spermatogenesis (HP:0008669)9.58827713
2Spontaneous abortion (HP:0005268)5.70144075
3Acute lymphatic leukemia (HP:0006721)4.72162079
4Abnormal gallbladder physiology (HP:0012438)4.47900333
5Cholecystitis (HP:0001082)4.47900333
6Shoulder girdle muscle weakness (HP:0003547)4.23443305
7Abnormality of the lower motor neuron (HP:0002366)4.18280458
8Progressive inability to walk (HP:0002505)4.15927184
9Upper motor neuron abnormality (HP:0002127)3.97276750
10Abnormality of glycolysis (HP:0004366)3.94901066
11Urethral obstruction (HP:0000796)3.86138397
12Sparse lateral eyebrow (HP:0005338)3.60825720
13Reticulocytosis (HP:0001923)3.58862841
14Gonadotropin excess (HP:0000837)3.53114854
15Increased serum pyruvate (HP:0003542)3.41476052
16Facial cleft (HP:0002006)3.30829254
17Obstructive sleep apnea (HP:0002870)3.22518145
18Abnormality of reticulocytes (HP:0004312)3.20925312
19Progressive external ophthalmoplegia (HP:0000590)3.16898016
20Ankyloglossia (HP:0010296)3.15838576
21Chromosomal breakage induced by crosslinking agents (HP:0003221)3.10904021
22Truncus arteriosus (HP:0001660)3.10800151
23Hyperthyroidism (HP:0000836)3.09806965
24Breast hypoplasia (HP:0003187)3.08251753
25Facial hemangioma (HP:0000329)3.05210788
26Agnosia (HP:0010524)2.99292996
27Homocystinuria (HP:0002156)2.98264374
28Abnormality of homocysteine metabolism (HP:0010919)2.98264374
29Basal cell carcinoma (HP:0002671)2.98160058
30Chromsome breakage (HP:0040012)2.95279665
31Increased hepatocellular lipid droplets (HP:0006565)2.93980811
32Pelvic girdle muscle weakness (HP:0003749)2.84958557
33Capillary hemangiomas (HP:0005306)2.84931200
34Lipid accumulation in hepatocytes (HP:0006561)2.77424593
35Abnormality of the tricuspid valve (HP:0001702)2.69724030
36Birth length less than 3rd percentile (HP:0003561)2.69119427
37Pallor (HP:0000980)2.68109364
38Abnormal hemoglobin (HP:0011902)2.64598521
39Upper limb muscle weakness (HP:0003484)2.63704490
40Hypoparathyroidism (HP:0000829)2.53481295
41Abnormal delivery (HP:0001787)2.50279868
42Cholelithiasis (HP:0001081)2.50021896
43Progressive muscle weakness (HP:0003323)2.48593920
44Megaloblastic anemia (HP:0001889)2.47529060
45Squamous cell carcinoma (HP:0002860)2.46293912
46Achilles tendon contracture (HP:0001771)2.44816155
47Abnormality of oral frenula (HP:0000190)2.43852522
48Amyotrophic lateral sclerosis (HP:0007354)2.41062419
49Vertebral compression fractures (HP:0002953)2.41040180
50Reticulocytopenia (HP:0001896)2.40834973
51Hypoplastic labia majora (HP:0000059)2.40213631
52Abnormality of the hip-girdle musculature (HP:0001445)2.38617919
53Abnormality of the musculature of the pelvis (HP:0001469)2.38617919
54Spastic paraparesis (HP:0002313)2.37034964
55Hydroureter (HP:0000072)2.34948961
56Overlapping toe (HP:0001845)2.34321849
57Seborrheic dermatitis (HP:0001051)2.34036035
58Dysmetric saccades (HP:0000641)2.33177755
59Esophageal neoplasm (HP:0100751)2.32399563
60Neoplasm of head and neck (HP:0012288)2.32399563
61Hyperammonemia (HP:0001987)2.32367219
62Abnormality of cells of the erythroid lineage (HP:0012130)2.31554160
63Prolonged neonatal jaundice (HP:0006579)2.31529050
64Ragged-red muscle fibers (HP:0003200)2.29907776
65Abnormality of the distal phalanges of the toes (HP:0010182)2.28491315
66Hypokinesia (HP:0002375)2.27930192
67Muscle fiber splitting (HP:0003555)2.27785757
68Limb-girdle muscle weakness (HP:0003325)2.26582502
69Abnormality of the vitamin B12 metabolism (HP:0004341)2.26410798
70Cerebral edema (HP:0002181)2.24939107
71Ankle contracture (HP:0006466)2.24451494
72Absent eyebrow (HP:0002223)2.24329439
73Hyperacusis (HP:0010780)2.23917414
74Elbow flexion contracture (HP:0002987)2.23817379
75External ophthalmoplegia (HP:0000544)2.22785145
76Increased connective tissue (HP:0009025)2.18573513
77Axonal loss (HP:0003447)2.17157233
78Bowel incontinence (HP:0002607)2.16633657
79Increased nuchal translucency (HP:0010880)2.14530562
80Abnormality of the Achilles tendon (HP:0005109)2.14366157
81Submucous cleft hard palate (HP:0000176)2.14248593
82Absent radius (HP:0003974)2.14214464
83Insomnia (HP:0100785)2.13240418
84Abnormality of the aortic arch (HP:0012303)2.13106176
85Abnormal large intestine physiology (HP:0012700)2.11937366
86Impulsivity (HP:0100710)2.11724113
87Prolonged partial thromboplastin time (HP:0003645)2.11432365
88Abnormal gallbladder morphology (HP:0012437)2.10550055
89Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.09326765
90Abnormality of vitamin B metabolism (HP:0004340)2.09270530
91Abnormality of the labia majora (HP:0012881)2.07447096
92Distal lower limb muscle weakness (HP:0009053)2.07111785
93Rhabdomyosarcoma (HP:0002859)2.06612652
94Shawl scrotum (HP:0000049)2.06212581
95Absent thumb (HP:0009777)2.06045903
96Abnormality of cochlea (HP:0000375)2.05863036
97Absent forearm bone (HP:0003953)2.05805218
98Aplasia involving forearm bones (HP:0009822)2.05805218
99Deep philtrum (HP:0002002)2.03422799
100Abnormality of the nasal septum (HP:0000419)2.03336444
101Abnormality of the preputium (HP:0100587)2.03158249
102Abnormality of the labia minora (HP:0012880)2.03036066
103Patellar dislocation (HP:0002999)2.01334406
104Microvesicular hepatic steatosis (HP:0001414)2.01183817
105Azoospermia (HP:0000027)12.3603301
106Trismus (HP:0000211)1.99881731
107Termporal pattern (HP:0011008)1.99562502
108Insidious onset (HP:0003587)1.99562502
109Rectal fistula (HP:0100590)1.99238346
110Rectovaginal fistula (HP:0000143)1.99238346
111Cutaneous melanoma (HP:0012056)1.97391238
112Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97041059
113Rough bone trabeculation (HP:0100670)1.97010189
114Hyperglycemia (HP:0003074)1.96417440
115Germ cell neoplasia (HP:0100728)1.95755120
116Polycythemia (HP:0001901)1.94736295
117Rimmed vacuoles (HP:0003805)1.94554312
118Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.94307888
119Morphological abnormality of the inner ear (HP:0011390)1.93534961
120Orthostatic hypotension (HP:0001278)1.92001837
121Secondary amenorrhea (HP:0000869)1.91820079
122Global brain atrophy (HP:0002283)1.91781094
123Cerebral hypomyelination (HP:0006808)1.90834694
124Abnormality of pyrimidine metabolism (HP:0004353)1.90182828
125Vaginal fistula (HP:0004320)1.89703655
126Cortical dysplasia (HP:0002539)1.89676577
127Abnormality of methionine metabolism (HP:0010901)1.89062100
128Annular pancreas (HP:0001734)1.88683310
129Relative macrocephaly (HP:0004482)1.88594819
130Bundle branch block (HP:0011710)1.87995936
131Abnormality of the gallbladder (HP:0005264)1.86897432
132Abnormality of the heme biosynthetic pathway (HP:0010472)1.85183446
133Abnormal number of erythroid precursors (HP:0012131)1.83901132
134Hypertensive crisis (HP:0100735)1.83723159
135Abnormality of aromatic amino acid family metabolism (HP:0004338)1.82026834
136Long palpebral fissure (HP:0000637)1.81978139
137Asymmetry of the thorax (HP:0001555)1.81719803
138Entropion (HP:0000621)1.81511609
139Low anterior hairline (HP:0000294)1.81506136
140Respiratory difficulties (HP:0002880)1.81349484
141Abnormality of the umbilical cord (HP:0010881)1.80098183
142Poor eye contact (HP:0000817)1.79521958
143Patchy hypopigmentation of hair (HP:0011365)1.79409829
144Paraparesis (HP:0002385)1.79146549
145Abnormality of vitamin metabolism (HP:0100508)1.77976752
146Cleft eyelid (HP:0000625)1.77720802
147Impaired pain sensation (HP:0007328)1.77702625
148Abnormality of pain sensation (HP:0010832)1.77702625
149Carpal bone hypoplasia (HP:0001498)1.77181521
150Patellar aplasia (HP:0006443)1.75972343
151Posterior subcapsular cataract (HP:0007787)1.75609044
152Hyperbilirubinemia (HP:0002904)1.75530144
153Short tibia (HP:0005736)1.75487304
154Hypoplasia of the radius (HP:0002984)1.75456319
155Abnormal mitochondria in muscle tissue (HP:0008316)1.75198508
156Acute encephalopathy (HP:0006846)1.74922228
157Myelodysplasia (HP:0002863)1.73959208
158Hypobetalipoproteinemia (HP:0003563)1.73742033
159White forelock (HP:0002211)1.73102107
160Colon cancer (HP:0003003)1.73032715
161Ureteral duplication (HP:0000073)1.72785361
162Proximal placement of thumb (HP:0009623)1.72572649
163Reduced antithrombin III activity (HP:0001976)1.71466240
164Overriding aorta (HP:0002623)1.71124155
165Macrocytic anemia (HP:0001972)1.70437743
166Abnormality of subcutaneous fat tissue (HP:0001001)1.70178287
167Aplasia/Hypoplasia of the macula (HP:0008059)1.69707900
168Atrophy/Degeneration involving motor neurons (HP:0007373)1.69291885
169Renal duplication (HP:0000075)1.68539098
170Deviation of the thumb (HP:0009603)1.68238231
171Lower limb amyotrophy (HP:0007210)1.67129198
172Short nail (HP:0001799)1.66975618
173Horseshoe kidney (HP:0000085)1.66621304
174Aplasia/Hypoplasia of the tibia (HP:0005772)1.65512085
175Gonadal dysgenesis (HP:0000133)1.65393619
176Disinhibition (HP:0000734)1.64741766
177Abnormal pancreas size (HP:0012094)1.64369350
178Hyporeflexia of lower limbs (HP:0002600)1.62802595
179Premature ovarian failure (HP:0008209)1.62684393
180Hand muscle atrophy (HP:0009130)1.61258132
181Delayed myelination (HP:0012448)1.61140853
182Difficulty running (HP:0009046)1.60794586
183Abnormality of sulfur amino acid metabolism (HP:0004339)1.59460398
184Inability to walk (HP:0002540)1.59359466
185Aplasia/Hypoplasia of the patella (HP:0006498)1.59309115

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.37408942
2PRKD34.34221965
3PRPF4B3.08927653
4NEK12.95019921
5NME22.94179236
6MST1R2.84551532
7EEF2K2.71776657
8ICK2.65936883
9TAOK22.41854197
10TSSK62.24919163
11NTRK32.24393022
12MAP3K42.07741826
13TRIB32.00840567
14ACVR1B11.4960813
15WNK41.77359056
16SRPK11.76813904
17RPS6KB21.75292367
18KSR11.69223034
19BRSK21.67224474
20SCYL21.65394481
21EPHA21.63811378
22KSR21.61504395
23WNK31.58471476
24SMG11.54455480
25PAK41.48267917
26CDK121.46982896
27MET1.35709303
28ERBB41.31381464
29CDC42BPA1.25817551
30NLK1.25133171
31MAP3K81.24785138
32CDK71.19804378
33BRAF1.19582988
34CCNB11.19008619
35IRAK11.17535760
36PLK31.16840130
37PINK11.14673448
38BMPR21.13725428
39NEK21.12542378
40RAF11.11708114
41PLK21.10693442
42TTK1.07198122
43MAP3K31.05679909
44CLK11.05665391
45AURKB1.03884113
46MARK10.98391521
47BUB10.97460645
48RIPK40.97340483
49CHEK10.96686738
50MAPK130.92168807
51EIF2AK30.89754917
52CDK80.88193846
53PLK10.87811021
54STK390.87386142
55AKT30.86712635
56SIK10.85493759
57MTOR0.85366785
58MAP2K30.84483729
59MARK30.83101011
60NME10.80604278
61ERN10.80264363
62ATM0.80262601
63BCR0.80179953
64ILK0.77793029
65ARAF0.77403105
66DYRK1A0.75895354
67PTK2B0.74668453
68IRAK30.73988648
69PKN20.73779023
70DYRK20.73456788
71BRSK10.70925261
72STK160.69406127
73WEE10.67902171
74AKT20.64413294
75EIF2AK10.64089720
76NEK60.63777348
77TTN0.63537393
78SIK30.63478043
79PDGFRA0.62653001
80RIPK10.62277667
81TESK20.60721482
82PTK20.60258620
83MAP3K20.59155228
84GRK50.58725044
85MAPKAPK50.58634264
86PRKCI0.57595449
87LATS10.57028690
88SGK20.57006324
89VRK20.55966803
90PLK40.55891389
91IRAK20.55039153
92LRRK20.54733949
93CSNK1G10.54723385
94LATS20.53175712
95STK40.52373850
96NTRK10.52167934
97CHEK20.52115667
98LMTK20.51734010
99PRKCH0.50485792
100CDK40.49901726
101MAP3K90.49668628
102ATR0.49213071
103CSNK2A20.48827842
104MELK0.48786821
105PAK20.47372757
106PAK10.47229074
107TYRO30.46664896
108MKNK10.46636849
109BMX0.45473370
110MAP2K40.45421821
111WNK10.45402080
112BRD40.44740500
113MST40.44736360
114PASK0.44000175
115MKNK20.43727125
116GRK60.43564946
117PRKCZ0.43563931
118AURKA0.43524881
119RPS6KA40.43333482
120MAPKAPK30.43290976
121PRKD20.41832578
122MAPK110.38868796
123PTK60.38797901
124PRKDC0.38415514
125CDK20.38186885
126STK100.38062752
127STK110.36877293
128DAPK20.36407334
129FGR0.36111232
130CDK10.36031995
131CDK60.35841436
132PIM10.35509322
133PDK20.35500484
134MAP3K130.34960017
135BLK0.34373920
136RPS6KB10.34337102
137SGK4940.33963118
138SGK2230.33963118
139CSNK1E0.33371612
140EPHB10.32183329
141EIF2AK20.32023330
142TESK10.31462429
143PBK0.30595212
144ALK0.29103434
145MAP2K10.28477428
146PRKCG0.26525466
147ZAK0.25708842
148EPHA30.25431304
149TNIK0.25413245
150CSNK2A10.25153209
151CAMK2B0.24899750
152LIMK10.24535784
153PDGFRB0.24504355
154PHKG20.22566872
155PHKG10.22566872
156CSNK1D0.22249411
157TNK20.21587444
158PDK30.21401168
159PDK40.21401168
160PAK60.20717786
161GSK3B0.20089605
162FER0.19614582
163TRPM70.19451181
164RPS6KA30.19296359

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030085.82300602
2Caffeine metabolism_Homo sapiens_hsa002325.07388824
3Non-homologous end-joining_Homo sapiens_hsa034503.94456340
4Homologous recombination_Homo sapiens_hsa034403.57071356
5Basal transcription factors_Homo sapiens_hsa030223.56089715
6Proteasome_Homo sapiens_hsa030503.43649204
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.23034633
8Linoleic acid metabolism_Homo sapiens_hsa005912.87385964
9RNA transport_Homo sapiens_hsa030132.82031940
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.70779395
11DNA replication_Homo sapiens_hsa030302.44118741
12Fat digestion and absorption_Homo sapiens_hsa049752.18313872
13Carbon metabolism_Homo sapiens_hsa012002.11476624
14Cell cycle_Homo sapiens_hsa041102.05362978
15Ether lipid metabolism_Homo sapiens_hsa005651.98135981
16Pyruvate metabolism_Homo sapiens_hsa006201.95783428
17Fanconi anemia pathway_Homo sapiens_hsa034601.90926641
18Dorso-ventral axis formation_Homo sapiens_hsa043201.80107927
19Spliceosome_Homo sapiens_hsa030401.76401752
20RNA polymerase_Homo sapiens_hsa030201.74854707
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73453076
22mRNA surveillance pathway_Homo sapiens_hsa030151.71888907
23Fructose and mannose metabolism_Homo sapiens_hsa000511.68109188
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.61902147
25Sulfur relay system_Homo sapiens_hsa041221.46009239
26RNA degradation_Homo sapiens_hsa030181.40155079
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.38657803
28p53 signaling pathway_Homo sapiens_hsa041151.38087056
29Oocyte meiosis_Homo sapiens_hsa041141.37334320
30Mismatch repair_Homo sapiens_hsa034301.32501510
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30214153
32Arachidonic acid metabolism_Homo sapiens_hsa005901.29430161
33One carbon pool by folate_Homo sapiens_hsa006701.27738311
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.26894698
35N-Glycan biosynthesis_Homo sapiens_hsa005101.24998981
36Vitamin B6 metabolism_Homo sapiens_hsa007501.20406488
37Ribosome_Homo sapiens_hsa030101.18989262
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18651832
39Phenylalanine metabolism_Homo sapiens_hsa003601.18423669
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.18027369
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17660099
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16820641
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11998146
44Galactose metabolism_Homo sapiens_hsa000521.04198528
45Butanoate metabolism_Homo sapiens_hsa006501.04001480
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03002975
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01447315
48Histidine metabolism_Homo sapiens_hsa003400.95188522
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.95066206
50Selenocompound metabolism_Homo sapiens_hsa004500.94238765
51Mineral absorption_Homo sapiens_hsa049780.93120457
52Nucleotide excision repair_Homo sapiens_hsa034200.91827192
53Glycerophospholipid metabolism_Homo sapiens_hsa005640.91700823
54Base excision repair_Homo sapiens_hsa034100.90367687
55Huntingtons disease_Homo sapiens_hsa050160.89595053
56Nicotine addiction_Homo sapiens_hsa050330.83542274
57Long-term potentiation_Homo sapiens_hsa047200.83339263
58Chronic myeloid leukemia_Homo sapiens_hsa052200.83032687
59Folate biosynthesis_Homo sapiens_hsa007900.81104431
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79919450
61Fatty acid elongation_Homo sapiens_hsa000620.79806202
62Tight junction_Homo sapiens_hsa045300.79665313
63Pentose phosphate pathway_Homo sapiens_hsa000300.78926574
64Bladder cancer_Homo sapiens_hsa052190.74228572
65Non-small cell lung cancer_Homo sapiens_hsa052230.73581458
66Tyrosine metabolism_Homo sapiens_hsa003500.73065845
67Epstein-Barr virus infection_Homo sapiens_hsa051690.72411532
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70804944
69Small cell lung cancer_Homo sapiens_hsa052220.69320750
70Pyrimidine metabolism_Homo sapiens_hsa002400.68729891
71Sulfur metabolism_Homo sapiens_hsa009200.63372067
72Viral carcinogenesis_Homo sapiens_hsa052030.63262118
73Herpes simplex infection_Homo sapiens_hsa051680.63059913
74Biosynthesis of amino acids_Homo sapiens_hsa012300.63017246
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62724425
76Prion diseases_Homo sapiens_hsa050200.61311029
77Vitamin digestion and absorption_Homo sapiens_hsa049770.60868754
78Fatty acid metabolism_Homo sapiens_hsa012120.60399125
79Protein export_Homo sapiens_hsa030600.58899138
80Oxidative phosphorylation_Homo sapiens_hsa001900.58879609
81Pancreatic cancer_Homo sapiens_hsa052120.58644974
82Other glycan degradation_Homo sapiens_hsa005110.58115836
83Calcium signaling pathway_Homo sapiens_hsa040200.56693191
84Purine metabolism_Homo sapiens_hsa002300.56678937
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55307330
86mTOR signaling pathway_Homo sapiens_hsa041500.54840342
87Pancreatic secretion_Homo sapiens_hsa049720.54754988
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53493924
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.53451247
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52576669
91Regulation of autophagy_Homo sapiens_hsa041400.52083288
92Chemical carcinogenesis_Homo sapiens_hsa052040.51752921
93Complement and coagulation cascades_Homo sapiens_hsa046100.51661350
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.51004901
95Metabolic pathways_Homo sapiens_hsa011000.49221950
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48451240
97Arginine and proline metabolism_Homo sapiens_hsa003300.48350702
98Vibrio cholerae infection_Homo sapiens_hsa051100.46180124
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45250469
100Alzheimers disease_Homo sapiens_hsa050100.43347549
101MicroRNAs in cancer_Homo sapiens_hsa052060.43248419
102Acute myeloid leukemia_Homo sapiens_hsa052210.43119729
103Fatty acid degradation_Homo sapiens_hsa000710.42711266
104Arginine biosynthesis_Homo sapiens_hsa002200.42460336
105Insulin signaling pathway_Homo sapiens_hsa049100.42272540
106Parkinsons disease_Homo sapiens_hsa050120.41961653
107HIF-1 signaling pathway_Homo sapiens_hsa040660.41940786
108HTLV-I infection_Homo sapiens_hsa051660.41863004
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41231605
110Renal cell carcinoma_Homo sapiens_hsa052110.41200771
111Propanoate metabolism_Homo sapiens_hsa006400.40905598
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40682890
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.39001363
114Renin-angiotensin system_Homo sapiens_hsa046140.38307260
115Endometrial cancer_Homo sapiens_hsa052130.38007620
116Lysine degradation_Homo sapiens_hsa003100.35676891
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35520565
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32678068
119Prostate cancer_Homo sapiens_hsa052150.31392870
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30683437
121Glioma_Homo sapiens_hsa052140.29632426
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29151540
123Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28853211
124Amphetamine addiction_Homo sapiens_hsa050310.28252574
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.28203086
126Thyroid cancer_Homo sapiens_hsa052160.27320339
127Axon guidance_Homo sapiens_hsa043600.27179769
128Circadian entrainment_Homo sapiens_hsa047130.27083798
129Glutamatergic synapse_Homo sapiens_hsa047240.26099093
130VEGF signaling pathway_Homo sapiens_hsa043700.25973174
131beta-Alanine metabolism_Homo sapiens_hsa004100.25899306
132Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25897840
133ErbB signaling pathway_Homo sapiens_hsa040120.24278661
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.23464242
135Glucagon signaling pathway_Homo sapiens_hsa049220.21866223
136Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21073880
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19373525
138Adherens junction_Homo sapiens_hsa045200.18496857
139Glycerolipid metabolism_Homo sapiens_hsa005610.17452561
140Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.16294725
141SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15762460
142Dopaminergic synapse_Homo sapiens_hsa047280.15575219
143Glutathione metabolism_Homo sapiens_hsa004800.15379467
144Hippo signaling pathway_Homo sapiens_hsa043900.14261475
145Fatty acid biosynthesis_Homo sapiens_hsa000610.12982808
146Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.11644832
147Ras signaling pathway_Homo sapiens_hsa040140.11415633
148Synaptic vesicle cycle_Homo sapiens_hsa047210.10856121
149Tryptophan metabolism_Homo sapiens_hsa003800.09722090
150Salmonella infection_Homo sapiens_hsa051320.09241207
151Staphylococcus aureus infection_Homo sapiens_hsa051500.09006755

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