MAGEA8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis (GO:0007140)9.31342522
2chromosome organization involved in meiosis (GO:0070192)8.72038305
3meiotic nuclear division (GO:0007126)8.64989605
4regulation of meiosis I (GO:0060631)7.89892242
5male meiosis I (GO:0007141)7.53170591
6positive regulation of translational initiation (GO:0045948)6.83815574
7folic acid-containing compound biosynthetic process (GO:0009396)6.57866655
8meiosis I (GO:0007127)6.42949020
9reciprocal DNA recombination (GO:0035825)6.23465439
10reciprocal meiotic recombination (GO:0007131)6.23465439
11positive regulation of meiosis (GO:0045836)6.20658450
12meiotic cell cycle process (GO:1903046)6.17643779
13DNA alkylation (GO:0006305)5.95787144
14DNA methylation (GO:0006306)5.95787144
15gene silencing by RNA (GO:0031047)5.90133862
16DNA synthesis involved in DNA repair (GO:0000731)5.80966226
17positive regulation of meiotic cell cycle (GO:0051446)5.78764361
18meiotic chromosome segregation (GO:0045132)5.72048168
19oocyte maturation (GO:0001556)5.58668005
20homocysteine metabolic process (GO:0050667)5.52905898
21DNA replication checkpoint (GO:0000076)5.50274912
22IMP biosynthetic process (GO:0006188)5.46446511
23oogenesis (GO:0048477)5.07319529
24negative regulation of protein acetylation (GO:1901984)5.05579624
25IMP metabolic process (GO:0046040)4.76288398
26tetrahydrofolate metabolic process (GO:0046653)4.73240634
27DNA methylation or demethylation (GO:0044728)4.67356834
28proline biosynthetic process (GO:0006561)4.62902944
29attachment of spindle microtubules to kinetochore (GO:0008608)4.62292833
30L-serine metabolic process (GO:0006563)4.55588309
31protein-cofactor linkage (GO:0018065)4.48585277
32nuclear pore organization (GO:0006999)4.45083969
33DNA strand elongation involved in DNA replication (GO:0006271)4.41089912
34pteridine-containing compound biosynthetic process (GO:0042559)4.38424139
35proteasome assembly (GO:0043248)4.34315971
36regulation of double-strand break repair via homologous recombination (GO:0010569)4.28297428
37nuclear pore complex assembly (GO:0051292)4.26665260
38regulation of gonadotropin secretion (GO:0032276)4.26400140
39DNA strand elongation (GO:0022616)4.23368051
40ribosome biogenesis (GO:0042254)4.22869944
41formation of translation preinitiation complex (GO:0001731)4.22574532
42telomere maintenance via semi-conservative replication (GO:0032201)4.22283054
43folic acid-containing compound metabolic process (GO:0006760)4.19145370
44resolution of meiotic recombination intermediates (GO:0000712)4.18910594
45DNA replication initiation (GO:0006270)4.18771988
46regulation of translational fidelity (GO:0006450)4.14674414
47cellular protein catabolic process (GO:0044257)4.14353161
48negative regulation of meiosis (GO:0045835)4.06387162
49mitotic chromosome condensation (GO:0007076)4.05996592
50synapsis (GO:0007129)4.02130197
51nucleobase biosynthetic process (GO:0046112)3.99671708
52heterochromatin organization (GO:0070828)3.97116050
53protein K6-linked ubiquitination (GO:0085020)3.95657898
54gene silencing (GO:0016458)3.95518432
55DNA modification (GO:0006304)3.85756424
56mitotic sister chromatid segregation (GO:0000070)3.83746445
57cysteine metabolic process (GO:0006534)3.79003750
58regulation of meiosis (GO:0040020)3.78306765
59regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.77936904
60folic acid metabolic process (GO:0046655)3.75388277
61telomere maintenance via recombination (GO:0000722)3.68130143
62sister chromatid segregation (GO:0000819)3.68123884
63mitochondrial RNA metabolic process (GO:0000959)3.66507396
64kinetochore organization (GO:0051383)3.64496029
65estrogen biosynthetic process (GO:0006703)3.64473837
66sister chromatid cohesion (GO:0007062)3.64268221
67tRNA aminoacylation for protein translation (GO:0006418)3.61400758
68kinetochore assembly (GO:0051382)3.58956661
69chromatin remodeling at centromere (GO:0031055)3.56049340
70regulation of hippo signaling (GO:0035330)3.55549871
71DNA replication-dependent nucleosome organization (GO:0034723)3.53078639
72DNA replication-dependent nucleosome assembly (GO:0006335)3.53078639
73tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.51989105
74RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.51989105
75rRNA methylation (GO:0031167)3.50036012
76female gamete generation (GO:0007292)3.48440984
77purine nucleotide salvage (GO:0032261)3.46606104
78maturation of SSU-rRNA (GO:0030490)3.44801932
79rRNA modification (GO:0000154)3.43428018
80mitotic recombination (GO:0006312)3.43053656
81amino acid activation (GO:0043038)3.41665978
82tRNA aminoacylation (GO:0043039)3.41665978
83pteridine-containing compound metabolic process (GO:0042558)3.41587557
84viral mRNA export from host cell nucleus (GO:0046784)3.37845410
85serine family amino acid biosynthetic process (GO:0009070)3.37573023
86sulfur amino acid catabolic process (GO:0000098)3.36581377
87mitotic nuclear envelope disassembly (GO:0007077)3.34526391
88chromosome condensation (GO:0030261)3.34171033
89regulation of protein sumoylation (GO:0033233)3.34152992
90mitotic spindle assembly checkpoint (GO:0007094)3.33977667
91histone exchange (GO:0043486)3.30717013
92nuclear division (GO:0000280)3.29969546
93mRNA export from nucleus (GO:0006406)3.27628849
94mitotic spindle checkpoint (GO:0071174)3.26842110
95spindle assembly checkpoint (GO:0071173)3.26718845
96blastocyst development (GO:0001824)3.26585536
97DNA packaging (GO:0006323)3.24788486
98peptidyl-arginine omega-N-methylation (GO:0035247)3.24097301
99proline metabolic process (GO:0006560)3.23514010
100regulation of translation in response to stress (GO:0043555)3.23481722
101spindle checkpoint (GO:0031577)3.19520988
102negative regulation of mitotic sister chromatid separation (GO:2000816)3.17937299
103negative regulation of mitotic sister chromatid segregation (GO:0033048)3.17937299
104negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.17937299
105negative regulation of sister chromatid segregation (GO:0033046)3.17937299
106negative regulation of chromosome segregation (GO:0051985)3.16936345
107cullin deneddylation (GO:0010388)3.16475749
108pore complex assembly (GO:0046931)3.16431388
109sulfur amino acid biosynthetic process (GO:0000097)3.15084986
110regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.12591348
111transcription from mitochondrial promoter (GO:0006390)3.12009740
112ribonucleoprotein complex biogenesis (GO:0022613)3.10115607
113RNA export from nucleus (GO:0006405)3.09475418
114oocyte development (GO:0048599)3.07703649
115regulation of meiotic cell cycle (GO:0051445)3.06670725
116negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.06530420
117chromosome organization (GO:0051276)3.06328317
118mitotic metaphase plate congression (GO:0007080)3.05616188
119protein localization to chromosome, centromeric region (GO:0071459)3.05319556
120purine nucleobase biosynthetic process (GO:0009113)3.03893703
121DNA replication-independent nucleosome assembly (GO:0006336)3.02675564
122DNA replication-independent nucleosome organization (GO:0034724)3.02675564
123regulation of mitotic metaphase/anaphase transition (GO:0030071)3.01939935
124regulation of chromosome segregation (GO:0051983)3.01386514
125peptidyl-proline hydroxylation (GO:0019511)3.01169425
126regulation of double-strand break repair (GO:2000779)3.00776455
127protein neddylation (GO:0045116)3.00601485
128ribosome assembly (GO:0042255)2.99683673
129organelle fission (GO:0048285)2.99529419
130DNA unwinding involved in DNA replication (GO:0006268)2.99425248
131nuclear envelope disassembly (GO:0051081)2.99270058
132membrane disassembly (GO:0030397)2.99270058
133intra-S DNA damage checkpoint (GO:0031573)2.98186208
134anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.98175168
135nucleotide-excision repair, DNA gap filling (GO:0006297)2.98023154
136microtubule depolymerization (GO:0007019)2.97194242
137desmosome organization (GO:0002934)2.97044179
138telomere maintenance via telomere lengthening (GO:0010833)2.96393239
139negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.95640141
140DNA topological change (GO:0006265)2.94366907
141regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.93489105
142regulation of mitotic sister chromatid separation (GO:0010965)2.92995560
143regulation of mitotic sister chromatid segregation (GO:0033047)2.92995560
144regulation of sister chromatid segregation (GO:0033045)2.92995560
145protein deneddylation (GO:0000338)2.92720921
146positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.91756651
147metaphase plate congression (GO:0051310)2.91024068
148peptidyl-arginine methylation (GO:0018216)2.90980717
149peptidyl-arginine N-methylation (GO:0035246)2.90980717
150negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.90756320
151DNA catabolic process, exonucleolytic (GO:0000738)2.89912233
152snRNA processing (GO:0016180)2.89607653
153meiotic cell cycle (GO:0051321)2.87761185
154regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.87651320
155CENP-A containing nucleosome assembly (GO:0034080)2.87115250
156germ cell development (GO:0007281)2.87075759
157DNA strand renaturation (GO:0000733)2.84335284
158protein localization to kinetochore (GO:0034501)2.84315478
159spermatogenesis (GO:0007283)2.83838141
160male gamete generation (GO:0048232)2.83820285
161positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83630516
162histone H4-K12 acetylation (GO:0043983)2.81741433
163mRNA transport (GO:0051028)2.81367163
164tRNA modification (GO:0006400)2.81251559
165oxidative phosphorylation (GO:0006119)2.80903106
166negative regulation of nuclear division (GO:0051784)2.80713335
167chromosome segregation (GO:0007059)2.80516119
168regulation of gene silencing by miRNA (GO:0060964)2.80403937
169regulation of gene silencing by RNA (GO:0060966)2.80403937
170COPII vesicle coating (GO:0048208)2.80302164
171negative regulation of ligase activity (GO:0051352)2.79302091
172piRNA metabolic process (GO:0034587)15.6716471
173DNA methylation involved in gamete generation (GO:0043046)13.2579693
174synaptonemal complex assembly (GO:0007130)12.9511646
175synaptonemal complex organization (GO:0070193)12.0072438

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.31453002
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.13814077
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.48242694
4RBPJ_22232070_ChIP-Seq_NCS_Mouse4.16208649
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.90835794
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.43727311
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.41700141
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.17879792
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.01717052
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.97353242
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.93207052
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.83598745
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.80445883
14AR_21909140_ChIP-Seq_LNCAP_Human2.62408388
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.61876110
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55157140
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.51183512
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40023014
19MYCN_18555785_ChIP-Seq_MESCs_Mouse2.35125466
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.35005174
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34011886
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.30960823
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.25101826
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.25101826
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.25101826
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24457846
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22464853
28E2F1_21310950_ChIP-Seq_MCF-7_Human2.19867091
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15686096
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09685987
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08028333
32ETS1_20019798_ChIP-Seq_JURKAT_Human2.05101177
33ZNF263_19887448_ChIP-Seq_K562_Human1.96725523
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.96448611
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95773873
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.94561869
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94357215
38VDR_23849224_ChIP-Seq_CD4+_Human1.92811999
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92535847
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90682906
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.88339282
42XRN2_22483619_ChIP-Seq_HELA_Human1.87182187
43DCP1A_22483619_ChIP-Seq_HELA_Human1.85458728
44CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.80807317
45RNF2_27304074_Chip-Seq_NSC_Mouse1.74591483
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.70788505
47NCOR1_26117541_ChIP-Seq_K562_Human1.64188147
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.59977149
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57086955
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56987964
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56083082
52FOXP3_21729870_ChIP-Seq_TREG_Human1.51976382
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50548339
54PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.49075681
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46263271
56GABP_19822575_ChIP-Seq_HepG2_Human1.41956979
57TTF2_22483619_ChIP-Seq_HELA_Human1.40668062
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35817283
59HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35395186
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.34997130
61GATA1_22025678_ChIP-Seq_K562_Human1.32459184
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31128979
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30394405
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27168138
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26017532
66ELK1_19687146_ChIP-ChIP_HELA_Human1.22025046
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13303277
68SOX17_20123909_ChIP-Seq_XEN_Mouse1.12673875
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12522349
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.11759270
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.11390191
72HTT_18923047_ChIP-ChIP_STHdh_Human1.10772038
73KDM5A_27292631_Chip-Seq_BREAST_Human1.08497916
74RUNX1_26923725_Chip-Seq_HPCs_Mouse1.05957500
75TFEB_21752829_ChIP-Seq_HELA_Human1.05736157
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03288465
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03271176
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99084131
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96975035
80MYC_18940864_ChIP-ChIP_HL60_Human0.96375161
81SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92284988
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91632650
83PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90859061
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90847550
85ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90596790
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90502314
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90497442
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90367028
89FLI1_27457419_Chip-Seq_LIVER_Mouse0.90243563
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89633392
91EWS_26573619_Chip-Seq_HEK293_Human0.87880971
92PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86984295
93FUS_26573619_Chip-Seq_HEK293_Human0.84874776
94SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83106241
95ATF3_27146783_Chip-Seq_COLON_Human0.80885082
96ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.80746247
97* GATA3_21867929_ChIP-Seq_TH1_Mouse0.80605155
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.80481412
99PKCTHETA_26484144_Chip-Seq_BREAST_Human0.80427407
100SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80126177
101REST_19997604_ChIP-ChIP_NEURONS_Mouse0.79727005
102TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.78923941
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78883930
104CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.78462602
105FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.77888020
106POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.77181531
107TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.76769549
108CIITA_25753668_ChIP-Seq_RAJI_Human0.76186938
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.72883443
110SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.69412463
111PCGF2_27294783_Chip-Seq_ESCs_Mouse0.69389565
112TBX5_21415370_ChIP-Seq_HL-1_Mouse0.69216520
113ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.69209659
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.67127818
115STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.67098434
116NANOG_16153702_ChIP-ChIP_HESCs_Human0.65310136
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.65113741
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.63564752
119TET1_21490601_ChIP-Seq_MESCs_Mouse0.62789828
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.62712789
121LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.62591760
122* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.61545257
123NANOG_18555785_ChIP-Seq_MESCs_Mouse0.60508756
124CHD1_26751641_Chip-Seq_LNCaP_Human0.60170096
125NOTCH1_21737748_ChIP-Seq_TLL_Human0.60123852
126BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.59994977
127HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.59813311
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.59296816
129LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.58939852
130TP53_16413492_ChIP-PET_HCT116_Human0.58852401
131HOXB4_20404135_ChIP-ChIP_EML_Mouse0.58332971
132DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.58016409
133EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.57757823

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence6.75765405
2MP0002210_abnormal_sex_determination4.74899954
3MP0003786_premature_aging4.57910769
4MP0003123_paternal_imprinting4.07584348
5MP0008058_abnormal_DNA_repair3.82242479
6MP0001145_abnormal_male_reproductive3.79621007
7MP0001929_abnormal_gametogenesis3.74095226
8MP0010094_abnormal_chromosome_stability3.40431398
9MP0000653_abnormal_sex_gland3.37354880
10MP0003698_abnormal_male_reproductive2.97336855
11MP0003693_abnormal_embryo_hatching2.85504805
12MP0003111_abnormal_nucleus_morphology2.83926931
13MP0004957_abnormal_blastocyst_morpholog2.65371765
14MP0000013_abnormal_adipose_tissue2.41994703
15MP0004147_increased_porphyrin_level2.40640096
16MP0003806_abnormal_nucleotide_metabolis2.29303157
17MP0003077_abnormal_cell_cycle2.29125136
18MP0008057_abnormal_DNA_replication2.13314749
19MP0008877_abnormal_DNA_methylation10.5034554
20MP0010352_gastrointestinal_tract_polyps1.97689209
21MP0002396_abnormal_hematopoietic_system1.95111497
22MP0008007_abnormal_cellular_replicative1.81473579
23MP0004808_abnormal_hematopoietic_stem1.80679053
24MP0008932_abnormal_embryonic_tissue1.79921957
25MP0001986_abnormal_taste_sensitivity1.79071045
26MP0002877_abnormal_melanocyte_morpholog1.77622100
27MP0002161_abnormal_fertility/fecundity1.77070015
28MP0000003_abnormal_adipose_tissue1.70778332
29MP0002160_abnormal_reproductive_system1.70386963
30MP0001730_embryonic_growth_arrest1.60292418
31MP0001119_abnormal_female_reproductive1.55725666
32MP0002139_abnormal_hepatobiliary_system1.55221290
33MP0000647_abnormal_sebaceous_gland1.46523641
34MP0003121_genomic_imprinting1.44931436
35MP0005670_abnormal_white_adipose1.44529527
36MP0006036_abnormal_mitochondrial_physio1.39144674
37MP0003186_abnormal_redox_activity1.38381164
38MP0004233_abnormal_muscle_weight1.35158550
39MP0003718_maternal_effect1.28837527
40MP0002132_abnormal_respiratory_system1.27492532
41MP0003941_abnormal_skin_development1.21739235
42MP0000350_abnormal_cell_proliferation1.17295251
43MP0001529_abnormal_vocalization1.14483956
44MP0005646_abnormal_pituitary_gland1.14092176
45MP0006035_abnormal_mitochondrial_morpho1.13426627
46MP0003699_abnormal_female_reproductive1.13346051
47MP0002736_abnormal_nociception_after1.10418663
48MP0009115_abnormal_fat_cell1.08272002
49MP0009672_abnormal_birth_weight1.07197242
50MP0006276_abnormal_autonomic_nervous1.05652058
51MP0008260_abnormal_autophagy1.01875254
52MP0005389_reproductive_system_phenotype0.95490937
53MP0002876_abnormal_thyroid_physiology0.95068462
54MP0006292_abnormal_olfactory_placode0.94904791
55MP0001697_abnormal_embryo_size0.94538442
56MP0005451_abnormal_body_composition0.93120858
57MP0003943_abnormal_hepatobiliary_system0.92445188
58MP0002085_abnormal_embryonic_tissue0.92421340
59MP0009697_abnormal_copulation0.92409802
60MP0004197_abnormal_fetal_growth/weight/0.91879496
61MP0003787_abnormal_imprinting0.91725554
62MP0005360_urolithiasis0.89528944
63MP0005257_abnormal_intraocular_pressure0.89432084
64MP0000313_abnormal_cell_death0.88446135
65MP0000358_abnormal_cell_content/0.86938832
66MP0003890_abnormal_embryonic-extraembry0.86087764
67MP0000678_abnormal_parathyroid_gland0.85160066
68MP0001502_abnormal_circadian_rhythm0.85098119
69MP0005380_embryogenesis_phenotype0.84437461
70MP0001672_abnormal_embryogenesis/_devel0.84437461
71MP0002163_abnormal_gland_morphology0.82247805
72MP0004782_abnormal_surfactant_physiolog0.80703387
73MP0005623_abnormal_meninges_morphology0.80254134
74MP0005379_endocrine/exocrine_gland_phen0.79480235
75MP0001764_abnormal_homeostasis0.79195593
76MP0005647_abnormal_sex_gland0.79088803
77MP0001346_abnormal_lacrimal_gland0.78210912
78MP0003315_abnormal_perineum_morphology0.77754186
79MP0005197_abnormal_uvea_morphology0.77470991
80MP0002019_abnormal_tumor_incidence0.76094179
81MP0002080_prenatal_lethality0.74870158
82MP0003984_embryonic_growth_retardation0.73814645
83MP0000534_abnormal_ureter_morphology0.73201488
84MP0002084_abnormal_developmental_patter0.73036842
85MP0000613_abnormal_salivary_gland0.71775662
86MP0003656_abnormal_erythrocyte_physiolo0.71704430
87MP0005334_abnormal_fat_pad0.69337153
88MP0010307_abnormal_tumor_latency0.68288221
89MP0001340_abnormal_eyelid_morphology0.67025787
90MP0009053_abnormal_anal_canal0.66976020
91MP0000598_abnormal_liver_morphology0.66828788
92MP0002088_abnormal_embryonic_growth/wei0.65554082
93MP0009703_decreased_birth_body0.65192134
94MP0001293_anophthalmia0.64983068
95MP0001919_abnormal_reproductive_system0.64628009
96MP0001873_stomach_inflammation0.64572689
97MP0004264_abnormal_extraembryonic_tissu0.64355183
98MP0002086_abnormal_extraembryonic_tissu0.63922786
99MP0003385_abnormal_body_wall0.62849303
100MP0003942_abnormal_urinary_system0.62160687
101MP0003959_abnormal_lean_body0.61732907
102MP0004084_abnormal_cardiac_muscle0.61111757
103MP0000372_irregular_coat_pigmentation0.61053629
104MP0001177_atelectasis0.60672817
105MP0005666_abnormal_adipose_tissue0.59611844
106MP0005377_hearing/vestibular/ear_phenot0.58370412
107MP0003878_abnormal_ear_physiology0.58370412
108MP0003936_abnormal_reproductive_system0.58347619
109MP0008775_abnormal_heart_ventricle0.57996591
110MP0003252_abnormal_bile_duct0.57966385
111MP0000639_abnormal_adrenal_gland0.57792725
112MP0003119_abnormal_digestive_system0.55615738
113MP0004185_abnormal_adipocyte_glucose0.55006199
114MP0001661_extended_life_span0.54208569
115MP0010234_abnormal_vibrissa_follicle0.51465859
116MP0002269_muscular_atrophy0.48927757
117MP0003632_abnormal_nervous_system0.48539741
118MP0001542_abnormal_bone_strength0.46634965
119MP0005621_abnormal_cell_physiology0.44254419
120MP0009333_abnormal_splenocyte_physiolog0.44156802
121MP0002233_abnormal_nose_morphology0.43956941
122MP0002735_abnormal_chemical_nociception0.43840249
123MP0005367_renal/urinary_system_phenotyp0.43572910
124MP0000516_abnormal_urinary_system0.43572910
125MP0005395_other_phenotype0.43143024
126MP0003567_abnormal_fetal_cardiomyocyte0.42569474
127MP0003705_abnormal_hypodermis_morpholog0.41749371
128MP0005332_abnormal_amino_acid0.41062437
129MP0005384_cellular_phenotype0.40944113
130MP0003755_abnormal_palate_morphology0.40565316
131MP0001727_abnormal_embryo_implantation0.38941994
132MP0000428_abnormal_craniofacial_morphol0.38864788
133MP0003136_yellow_coat_color0.37477155
134MP0003221_abnormal_cardiomyocyte_apopto0.36728652
135MP0005410_abnormal_fertilization0.34810780
136MP0005076_abnormal_cell_differentiation0.33831785
137MP0003861_abnormal_nervous_system0.30760778
138MP0004036_abnormal_muscle_relaxation0.29661037
139MP0006072_abnormal_retinal_apoptosis0.28769960
140MP0000427_abnormal_hair_cycle0.28411211
141MP0004215_abnormal_myocardial_fiber0.27603405
142MP0001853_heart_inflammation0.26567665
143MP0005266_abnormal_metabolism0.26158601
144MP0002009_preneoplasia0.25551224
145MP0005023_abnormal_wound_healing0.25069782
146MP0001915_intracranial_hemorrhage0.24570945
147MP0002970_abnormal_white_adipose0.24498243
148MP0005171_absent_coat_pigmentation0.23856362

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)5.18523177
2Abnormal gallbladder physiology (HP:0012438)4.76957891
3Cholecystitis (HP:0001082)4.76957891
4Abnormality of alanine metabolism (HP:0010916)4.73185647
5Hyperalaninemia (HP:0003348)4.73185647
6Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.73185647
7Shoulder girdle muscle weakness (HP:0003547)4.64170176
8Spontaneous abortion (HP:0005268)4.44438514
9Breast hypoplasia (HP:0003187)4.23075730
10Birth length less than 3rd percentile (HP:0003561)4.16653003
11Facial hemangioma (HP:0000329)3.75350935
12Small epiphyses (HP:0010585)3.71634603
13Carpal bone hypoplasia (HP:0001498)3.64108297
14Truncus arteriosus (HP:0001660)3.47756648
15Abnormality of the tricuspid valve (HP:0001702)3.46210152
16Abnormal umbilical cord blood vessels (HP:0011403)3.32276906
17Single umbilical artery (HP:0001195)3.32276906
18Abnormality of the fetal cardiovascular system (HP:0010948)3.32276906
19Seborrheic dermatitis (HP:0001051)3.31218852
20Progressive external ophthalmoplegia (HP:0000590)3.31140759
21Impulsivity (HP:0100710)3.30039528
22Capillary hemangiomas (HP:0005306)3.24911920
23Facial cleft (HP:0002006)3.24487330
24Pelvic girdle muscle weakness (HP:0003749)3.19257088
25Gonadotropin excess (HP:0000837)3.18587027
26Abnormality of the preputium (HP:0100587)3.13633269
27Hyperthyroidism (HP:0000836)3.08340799
28Chromsome breakage (HP:0040012)3.06449851
29Abnormality of sulfur amino acid metabolism (HP:0004339)3.05883670
30Abnormality of the aortic arch (HP:0012303)3.04186757
31Amyotrophic lateral sclerosis (HP:0007354)2.98489979
32Upper motor neuron abnormality (HP:0002127)2.98254109
33Acute lymphatic leukemia (HP:0006721)2.95646164
34Abnormality of the labia minora (HP:0012880)2.95543259
35Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.92162513
36Hypertensive crisis (HP:0100735)2.89276765
37Ankle contracture (HP:0006466)2.88516144
38Flattened epiphyses (HP:0003071)2.88455966
39Absent thumb (HP:0009777)2.86344465
40Bowel incontinence (HP:0002607)2.84414359
41Hypoparathyroidism (HP:0000829)2.84224841
42Abnormality of the umbilical cord (HP:0010881)2.74265178
43Abnormality of the hip-girdle musculature (HP:0001445)2.72874460
44Abnormality of the musculature of the pelvis (HP:0001469)2.72874460
45Ileus (HP:0002595)2.72811395
46Homocystinuria (HP:0002156)2.68553488
47Abnormality of homocysteine metabolism (HP:0010919)2.68553488
48Urethral obstruction (HP:0000796)2.65638715
49Reticulocytopenia (HP:0001896)2.64525497
50Abnormal large intestine physiology (HP:0012700)2.63850395
51Shawl scrotum (HP:0000049)2.63575042
52Subcapsular cataract (HP:0000523)2.63239151
53Limb-girdle muscle weakness (HP:0003325)2.63160592
54Atrophy/Degeneration involving motor neurons (HP:0007373)2.63108333
55Absent radius (HP:0003974)2.62435597
56Esophageal varix (HP:0002040)2.56950982
57Patellar aplasia (HP:0006443)2.50109127
58Absent forearm bone (HP:0003953)2.49556005
59Aplasia involving forearm bones (HP:0009822)2.49556005
60Ulnar bowing (HP:0003031)2.49451493
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.48348857
62Obstructive sleep apnea (HP:0002870)2.45098727
63Ankyloglossia (HP:0010296)2.44106155
64Fibular aplasia (HP:0002990)2.43809029
65Aplasia/Hypoplasia involving the musculature (HP:0001460)2.43070070
66Chromosomal breakage induced by crosslinking agents (HP:0003221)2.42762671
67Abnormality of reticulocytes (HP:0004312)2.41300108
68Abnormality of methionine metabolism (HP:0010901)2.39655802
69Chorioretinal atrophy (HP:0000533)2.36862706
70Premature ovarian failure (HP:0008209)2.34674219
71Aplasia/Hypoplasia of the patella (HP:0006498)2.34621408
72Reticulocytosis (HP:0001923)2.30298608
73Ureteral duplication (HP:0000073)2.30153507
74Abnormal biliary tract morphology (HP:0012440)2.28627466
75Breech presentation (HP:0001623)2.28019499
76Metaphyseal cupping (HP:0003021)2.27569183
77Basal cell carcinoma (HP:0002671)2.25638879
78Postnatal microcephaly (HP:0005484)2.25485025
79Abnormality of the renal collecting system (HP:0004742)2.25093790
80External ophthalmoplegia (HP:0000544)2.24401139
81Abnormality of glycolysis (HP:0004366)2.24162979
82Abnormality of the carotid arteries (HP:0005344)2.23875761
83Abnormality of the anterior horn cell (HP:0006802)2.23294863
84Degeneration of anterior horn cells (HP:0002398)2.23294863
85Myelodysplasia (HP:0002863)2.22432612
86Abnormality of DNA repair (HP:0003254)2.21430660
87Abnormality of the ileum (HP:0001549)2.21400394
88Duodenal stenosis (HP:0100867)2.20636387
89Small intestinal stenosis (HP:0012848)2.20636387
90Short tibia (HP:0005736)2.20597084
91Arteriovenous malformation (HP:0100026)2.20014474
92Squamous cell carcinoma (HP:0002860)2.18885047
93Cutaneous melanoma (HP:0012056)2.16770892
94Abnormality of chromosome stability (HP:0003220)2.15707175
95Abnormality of serum amino acid levels (HP:0003112)2.15203271
96Rectal fistula (HP:0100590)2.14130764
97Rectovaginal fistula (HP:0000143)2.14130764
98Tetraplegia (HP:0002445)2.11292851
99Abnormal delivery (HP:0001787)2.11234056
100Abnormality of the heme biosynthetic pathway (HP:0010472)2.09265621
101Hypergonadotropic hypogonadism (HP:0000815)2.08235882
102Papillary thyroid carcinoma (HP:0002895)2.07405409
103Abnormality of the nasal septum (HP:0000419)2.07009742
104Abnormality of cochlea (HP:0000375)2.06158616
105Pallor (HP:0000980)2.05797815
106Colon cancer (HP:0003003)2.04404828
107Horseshoe kidney (HP:0000085)2.03884107
108Rimmed vacuoles (HP:0003805)2.02743516
109Acute encephalopathy (HP:0006846)2.01483873
110Rough bone trabeculation (HP:0100670)2.00212484
111Azoospermia (HP:0000027)12.9651770
112Abnormal spermatogenesis (HP:0008669)10.6567533
113Posterior subcapsular cataract (HP:0007787)1.98042440
114Aplasia/Hypoplasia of the tibia (HP:0005772)1.97899437
115Type I transferrin isoform profile (HP:0003642)1.97401100
116Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96635385
117Megaloblastic anemia (HP:0001889)1.94890382
118Secondary amenorrhea (HP:0000869)1.94472090
119Ectopic kidney (HP:0000086)1.92725923
120Abnormality of the phalanges of the hallux (HP:0010057)1.92685305
121Hypoplastic labia majora (HP:0000059)1.92356752
122Increased nuchal translucency (HP:0010880)1.91864946
123Conjugated hyperbilirubinemia (HP:0002908)1.91532745
124Duplicated collecting system (HP:0000081)1.91021766
125Cholelithiasis (HP:0001081)1.90421583
126Abnormality of oral frenula (HP:0000190)1.89963634
127Constricted visual fields (HP:0001133)1.89575388
128Glioma (HP:0009733)1.89398222
129Rhabdomyosarcoma (HP:0002859)1.88453099
130Increased serum pyruvate (HP:0003542)1.87620908
131Increased hepatocellular lipid droplets (HP:0006565)1.87309793
132Short thumb (HP:0009778)1.87091873
133Hypoplasia of the radius (HP:0002984)1.86980613
134Neoplasm of the peripheral nervous system (HP:0100007)1.86214669
135Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.85504538
136Delayed closure of the anterior fontanelle (HP:0001476)1.85034747
137Tubulointerstitial nephritis (HP:0001970)1.84368719
138Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83954928
139Cerebral hypomyelination (HP:0006808)1.83927794
140Difficulty running (HP:0009046)1.83578333
141Vaginal fistula (HP:0004320)1.82825858
142Neoplasm of the adrenal cortex (HP:0100641)1.82610327
143Cleft eyelid (HP:0000625)1.81771442
144Patellar dislocation (HP:0002999)1.81410533
145Tinnitus (HP:0000360)1.81228152
146Cortical visual impairment (HP:0100704)1.80934261
147Hypobetalipoproteinemia (HP:0003563)1.80766374
148CNS hypomyelination (HP:0003429)1.79902734
149Hand muscle atrophy (HP:0009130)1.79116407
150Lipid accumulation in hepatocytes (HP:0006561)1.77842255
151Selective tooth agenesis (HP:0001592)1.76304975
152Biconcave vertebral bodies (HP:0004586)1.75114788
153Stenosis of the external auditory canal (HP:0000402)1.74865326
154Abnormal lung lobation (HP:0002101)1.74112659
155Bone marrow hypocellularity (HP:0005528)1.73672428
156Poikiloderma (HP:0001029)1.72994282
157Abnormality of the labia majora (HP:0012881)1.72872993
158Overlapping toe (HP:0001845)1.72675734
159Meckel diverticulum (HP:0002245)1.72249948
160Prolonged neonatal jaundice (HP:0006579)1.72168743
161Difficulty climbing stairs (HP:0003551)1.72083861
162Muscle fiber splitting (HP:0003555)1.71655381
163Low anterior hairline (HP:0000294)1.71396779
164Decreased subcutaneous fat (HP:0001002)1.70361147
165Upper limb muscle weakness (HP:0003484)1.69811521
166Intestinal fistula (HP:0100819)1.68056006
167Abnormalities of placenta or umbilical cord (HP:0001194)1.67717188
168Type 2 muscle fiber atrophy (HP:0003554)1.66993664
169Cafe-au-lait spot (HP:0000957)1.66821543
170Microvesicular hepatic steatosis (HP:0001414)1.66763261
171Ependymoma (HP:0002888)1.66762829
172Progressive inability to walk (HP:0002505)1.66644393
173Pustule (HP:0200039)1.66484681
174Abnormality of pyrimidine metabolism (HP:0004353)1.66065293
175Neoplasm of the pancreas (HP:0002894)1.65985910
176Short chin (HP:0000331)1.65509898
177Breast carcinoma (HP:0003002)1.64934986
178Limited elbow extension (HP:0001377)1.64894075
179Redundant skin (HP:0001582)1.63137068
180Proximal placement of thumb (HP:0009623)1.61809058
181Meningioma (HP:0002858)1.61659988
182Breast aplasia (HP:0100783)1.60755622
183Median cleft lip (HP:0000161)1.59908404

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.95606209
2CCNB12.71250726
3BUB12.62135458
4CDK122.53512988
5PRKD32.43804743
6MST42.34267266
7WEE12.27062980
8MST1R2.20642956
9NEK12.07746862
10NTRK12.07458701
11PBK2.04575173
12ACVR1B10.6002112
13LATS11.96712116
14PLK11.89485007
15KSR21.79703142
16IRAK31.77749536
17TTK1.74893826
18BMPR21.72555287
19NEK21.64793454
20PRPF4B1.59709157
21MAP3K121.57831189
22ZAK1.55574006
23PLK31.53153076
24MET1.51789680
25EPHA21.50055356
26ICK1.45151826
27NME21.40972047
28IRAK11.40922419
29CHEK11.39308973
30TAOK21.39020692
31BRSK11.35761483
32INSRR1.34685200
33PLK41.31032293
34KSR11.30444356
35MAP3K41.21841899
36EIF2AK21.21699025
37STK38L1.18697042
38EIF2AK11.13939312
39BRSK21.13179427
40RAF11.13173326
41BRD41.12740685
42MKNK21.12644648
43ATM1.10222365
44ATR1.10146462
45PINK11.08501411
46PDK31.07548215
47PDK41.07548215
48MELK1.05434417
49MARK31.00544899
50STK240.98965003
51CHEK20.97901026
52MAP3K30.97537197
53CDC42BPA0.97491066
54MAP3K20.96728950
55EIF2AK30.95672801
56PLK20.91289373
57AURKB0.88209395
58SRPK10.87134852
59TSSK60.85261579
60ERBB30.84544980
61BCR0.82134334
62SIK10.79758346
63STK100.78963283
64LATS20.78400403
65MARK10.78345630
66SCYL20.75070580
67TRPM70.74996326
68MATK0.74547636
69TTN0.73155871
70AURKA0.72968515
71MAP2K10.72809469
72DYRK30.71365943
73JAK20.69596614
74CDK20.69272303
75MKNK10.68229892
76ALK0.67357528
77NME10.65574526
78IRAK20.65378713
79PRKCI0.64790892
80MAP2K30.64520037
81JAK30.64072702
82CDK10.62266571
83CAMK2G0.60808270
84CDK90.60357512
85ILK0.59148395
86PDK20.58394466
87TLK10.58256169
88BMX0.56750254
89MTOR0.56092151
90DYRK20.55547645
91CSNK2A20.52928830
92CAMK2B0.49937466
93CDK70.47889179
94RPS6KA40.46182071
95PRKDC0.45370463
96TRIM280.44187648
97RET0.44008559
98FLT30.43820863
99PIM10.42471523
100CDK40.42354470
101CSNK1E0.41789004
102FGR0.41030676
103STK40.40903127
104CSNK2A10.40429980
105WNK10.40192118
106STK160.38077062
107AKT20.37756729
108LIMK10.37669041
109CSNK1D0.37234776
110CHUK0.36226611
111AKT30.35899300
112SIK30.35825456
113MAP2K40.35238431
114PRKG20.33508508
115PTK60.32809459
116BRAF0.32326624
117MAPK80.31448790
118GSK3B0.29039417
119STK30.28541676
120CAMK2D0.27295887
121RPS6KB20.26288665
122TGFBR10.25848494
123PDGFRA0.25381854
124CLK10.25180816
125PASK0.24853621
126LMTK20.22797347
127CDK80.22357378
128PAK60.20648455
129PAK40.20213666
130TESK10.19528540
131RPS6KB10.19139484
132TYRO30.18964951
133CSNK1G10.18947976
134MAPK100.18818138
135MAPK110.17861354
136NTRK30.16333429
137STK110.16172794
138PAK10.15038508
139MAP3K80.14400271
140DYRK1A0.14284552
141IRAK40.13802777

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030086.17160639
2Basal transcription factors_Homo sapiens_hsa030224.38679045
3Proteasome_Homo sapiens_hsa030504.31340544
4Homologous recombination_Homo sapiens_hsa034403.70319297
5DNA replication_Homo sapiens_hsa030303.59642411
6RNA transport_Homo sapiens_hsa030133.47042382
7RNA polymerase_Homo sapiens_hsa030203.20089179
8Non-homologous end-joining_Homo sapiens_hsa034502.98261887
9Mismatch repair_Homo sapiens_hsa034302.83523225
10Cell cycle_Homo sapiens_hsa041102.80966372
11Spliceosome_Homo sapiens_hsa030402.61668534
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.49501395
13mRNA surveillance pathway_Homo sapiens_hsa030152.47483112
14Nucleotide excision repair_Homo sapiens_hsa034202.38529126
15Caffeine metabolism_Homo sapiens_hsa002322.18187573
16Fanconi anemia pathway_Homo sapiens_hsa034602.08775071
17Base excision repair_Homo sapiens_hsa034101.87868298
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86539732
19RNA degradation_Homo sapiens_hsa030181.86409611
20Pyrimidine metabolism_Homo sapiens_hsa002401.83607569
21One carbon pool by folate_Homo sapiens_hsa006701.78947067
22Sulfur relay system_Homo sapiens_hsa041221.78886084
23N-Glycan biosynthesis_Homo sapiens_hsa005101.70946565
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.61240783
25Selenocompound metabolism_Homo sapiens_hsa004501.52192689
26Ribosome_Homo sapiens_hsa030101.51299394
27p53 signaling pathway_Homo sapiens_hsa041151.49306978
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48226029
29Oocyte meiosis_Homo sapiens_hsa041141.44245226
30Linoleic acid metabolism_Homo sapiens_hsa005911.43451218
31Pyruvate metabolism_Homo sapiens_hsa006201.41141189
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.35965579
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27700813
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24776972
35Purine metabolism_Homo sapiens_hsa002301.22556129
36Epstein-Barr virus infection_Homo sapiens_hsa051691.22425445
37Herpes simplex infection_Homo sapiens_hsa051681.09294984
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08522654
39Vitamin B6 metabolism_Homo sapiens_hsa007501.08201037
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.06785155
41Dorso-ventral axis formation_Homo sapiens_hsa043201.03451997
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03379760
43Huntingtons disease_Homo sapiens_hsa050160.99237620
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94508405
45Sulfur metabolism_Homo sapiens_hsa009200.92074542
46Fat digestion and absorption_Homo sapiens_hsa049750.91643137
47Ether lipid metabolism_Homo sapiens_hsa005650.87772850
48Regulation of autophagy_Homo sapiens_hsa041400.87723853
49Thyroid cancer_Homo sapiens_hsa052160.85212198
50Pentose phosphate pathway_Homo sapiens_hsa000300.81435984
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74632048
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.73923917
53Fatty acid biosynthesis_Homo sapiens_hsa000610.72270304
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72216062
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.72151749
56HTLV-I infection_Homo sapiens_hsa051660.68492422
57Fructose and mannose metabolism_Homo sapiens_hsa000510.67508562
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67092004
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.66745758
60Alcoholism_Homo sapiens_hsa050340.63663097
61Parkinsons disease_Homo sapiens_hsa050120.62175882
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.62001322
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61350595
64Alzheimers disease_Homo sapiens_hsa050100.60875025
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58267927
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57929779
67Galactose metabolism_Homo sapiens_hsa000520.56952226
68Biosynthesis of amino acids_Homo sapiens_hsa012300.56138279
69Arachidonic acid metabolism_Homo sapiens_hsa005900.55455250
70Propanoate metabolism_Homo sapiens_hsa006400.54873383
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50699359
72Chronic myeloid leukemia_Homo sapiens_hsa052200.49101738
73Tight junction_Homo sapiens_hsa045300.44234528
74Glutathione metabolism_Homo sapiens_hsa004800.44188489
75Fatty acid elongation_Homo sapiens_hsa000620.42596201
76Influenza A_Homo sapiens_hsa051640.39335181
77Hippo signaling pathway_Homo sapiens_hsa043900.37132196
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.36364004
79Folate biosynthesis_Homo sapiens_hsa007900.35682646
80Apoptosis_Homo sapiens_hsa042100.34181060
81Vitamin digestion and absorption_Homo sapiens_hsa049770.32116181
82Viral carcinogenesis_Homo sapiens_hsa052030.31873219
83Tyrosine metabolism_Homo sapiens_hsa003500.29814736
84Lysine degradation_Homo sapiens_hsa003100.28116448
85Glycerolipid metabolism_Homo sapiens_hsa005610.27907577
86FoxO signaling pathway_Homo sapiens_hsa040680.26687712
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25749217
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25699691
89Other glycan degradation_Homo sapiens_hsa005110.25116458
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23628477
91Bladder cancer_Homo sapiens_hsa052190.23244024
92Carbon metabolism_Homo sapiens_hsa012000.23040401
93Metabolic pathways_Homo sapiens_hsa011000.21561771
94Protein export_Homo sapiens_hsa030600.20544402
95Retinol metabolism_Homo sapiens_hsa008300.20506548
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20364531
97Ovarian steroidogenesis_Homo sapiens_hsa049130.19511552
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19218597
99MicroRNAs in cancer_Homo sapiens_hsa052060.19020918
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17264838
101TGF-beta signaling pathway_Homo sapiens_hsa043500.16857438
102Systemic lupus erythematosus_Homo sapiens_hsa053220.15721378
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14804740
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14556927
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.12666610
106Adherens junction_Homo sapiens_hsa045200.12520397
107Renal cell carcinoma_Homo sapiens_hsa052110.11865772
108Legionellosis_Homo sapiens_hsa051340.10573344
109Chemical carcinogenesis_Homo sapiens_hsa052040.10091737
110Pancreatic cancer_Homo sapiens_hsa052120.09948701
111Fatty acid metabolism_Homo sapiens_hsa012120.09352088
112Prion diseases_Homo sapiens_hsa050200.08856933
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.08770326
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.08424384
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.08370872
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.08308751
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.07595468
118Renin-angiotensin system_Homo sapiens_hsa046140.06658558
119Small cell lung cancer_Homo sapiens_hsa052220.06389196
120Steroid biosynthesis_Homo sapiens_hsa001000.06309560
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.04961817
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.03082802
123Oxidative phosphorylation_Homo sapiens_hsa001900.02348488
124Arginine biosynthesis_Homo sapiens_hsa00220-0.1023175
125Fatty acid degradation_Homo sapiens_hsa00071-0.0908717
126Notch signaling pathway_Homo sapiens_hsa04330-0.0852396
127Hedgehog signaling pathway_Homo sapiens_hsa04340-0.0843226
128HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0790964
129Ascorbate and aldarate metabolism_Homo sapiens_hsa00053-0.0787701
130Mineral absorption_Homo sapiens_hsa04978-0.0787305
131Pathways in cancer_Homo sapiens_hsa05200-0.0728913
132Butanoate metabolism_Homo sapiens_hsa00650-0.0603324
133Long-term potentiation_Homo sapiens_hsa04720-0.0568318
134Primary bile acid biosynthesis_Homo sapiens_hsa00120-0.0387650
135Histidine metabolism_Homo sapiens_hsa00340-0.0216497
136Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0168483
137Arginine and proline metabolism_Homo sapiens_hsa00330-0.0081527

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