MAGEA9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1secondary metabolite biosynthetic process (GO:0044550)9.95488591
2tyrosine metabolic process (GO:0006570)8.46128080
3developmental pigmentation (GO:0048066)6.96738995
4gonadal mesoderm development (GO:0007506)6.58816992
5endothelial tube morphogenesis (GO:0061154)6.05831413
6morphogenesis of an endothelium (GO:0003159)6.05831413
7positive regulation of DNA-dependent DNA replication (GO:2000105)4.82935221
8glomerular visceral epithelial cell development (GO:0072015)4.80163593
9mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.76938499
10pigment biosynthetic process (GO:0046148)4.66024350
11Golgi transport vesicle coating (GO:0048200)4.55720840
12COPI coating of Golgi vesicle (GO:0048205)4.55720840
13respiratory tube development (GO:0030323)4.32541384
14regulation of regulatory T cell differentiation (GO:0045589)4.25245162
15negative regulation of T cell differentiation in thymus (GO:0033085)4.25046701
16glomerular epithelial cell development (GO:0072310)4.22584645
17regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.19756341
18mesenchymal cell differentiation involved in kidney development (GO:0072161)4.09746128
19mesenchymal cell differentiation involved in renal system development (GO:2001012)4.09746128
20phenol-containing compound biosynthetic process (GO:0046189)4.08375929
21establishment of integrated proviral latency (GO:0075713)4.07293782
22regulation of translational fidelity (GO:0006450)4.01066624
23negative regulation of metanephros development (GO:0072217)3.98801951
24positive regulation of tolerance induction (GO:0002645)3.98469475
25pigment metabolic process (GO:0042440)3.88118845
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.78555740
27type B pancreatic cell development (GO:0003323)3.75125947
28negative regulation of chondrocyte differentiation (GO:0032331)3.75074192
29enteric nervous system development (GO:0048484)3.69849427
30ribosome assembly (GO:0042255)3.65593075
31regulation of translational termination (GO:0006449)3.64822839
32maturation of 5.8S rRNA (GO:0000460)3.56520570
33positive regulation of SMAD protein import into nucleus (GO:0060391)3.52315783
34pattern specification involved in kidney development (GO:0061004)3.51827012
35negative regulation of thymocyte apoptotic process (GO:0070244)3.50122593
36regulation of T cell tolerance induction (GO:0002664)3.48800768
37ribosome biogenesis (GO:0042254)3.45440429
38formation of translation preinitiation complex (GO:0001731)3.43520762
39proline biosynthetic process (GO:0006561)3.42253483
40protein complex localization (GO:0031503)3.40990233
41endocardial cushion development (GO:0003197)3.35833458
42cellular response to arsenic-containing substance (GO:0071243)3.35815006
43positive regulation of endothelial cell differentiation (GO:0045603)3.35520804
44DNA unwinding involved in DNA replication (GO:0006268)3.21820121
45mitotic chromosome condensation (GO:0007076)3.21458483
46ribonucleoprotein complex biogenesis (GO:0022613)3.20782924
47ribosomal small subunit biogenesis (GO:0042274)3.19854703
48viral mRNA export from host cell nucleus (GO:0046784)3.19431319
49endothelial cell proliferation (GO:0001935)3.15440203
50regulation of cell proliferation involved in kidney development (GO:1901722)3.14278475
51somatic stem cell division (GO:0048103)3.11536818
52melanocyte differentiation (GO:0030318)3.11266769
53lymphoid progenitor cell differentiation (GO:0002320)3.10730654
54spliceosomal tri-snRNP complex assembly (GO:0000244)3.07124029
55negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06272783
56heart field specification (GO:0003128)3.05998905
57secondary heart field specification (GO:0003139)3.05998905
58transcription from mitochondrial promoter (GO:0006390)3.02743444
59collecting duct development (GO:0072044)2.97968294
60maturation of SSU-rRNA (GO:0030490)2.96719159
61glandular epithelial cell development (GO:0002068)2.95234676
62negative regulation of stem cell proliferation (GO:2000647)2.95084100
63cranial suture morphogenesis (GO:0060363)2.94948815
64negative regulation of cartilage development (GO:0061037)2.93481963
65establishment of viral latency (GO:0019043)2.92581773
66nuclear pore complex assembly (GO:0051292)2.90248791
67positive regulation of epidermal cell differentiation (GO:0045606)2.89930261
68positive regulation of neuroblast proliferation (GO:0002052)2.88820367
69mitotic nuclear envelope reassembly (GO:0007084)2.85693009
70nuclear envelope reassembly (GO:0031468)2.85693009
71pigment cell differentiation (GO:0050931)2.84491451
72regulation of translational elongation (GO:0006448)2.84267073
73ribosomal large subunit biogenesis (GO:0042273)2.84092846
74pigmentation (GO:0043473)2.82764802
75secondary metabolic process (GO:0019748)2.82335529
76regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.81819831
77embryonic skeletal joint morphogenesis (GO:0060272)2.77989219
78regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.77986542
79mitotic sister chromatid segregation (GO:0000070)2.77683142
80cGMP-mediated signaling (GO:0019934)2.76607985
81aromatic amino acid family metabolic process (GO:0009072)2.75586322
82negative regulation of protein acetylation (GO:1901984)2.75363712
83mitotic nuclear envelope disassembly (GO:0007077)2.72440038
84chaperone-mediated protein complex assembly (GO:0051131)2.71012889
85renal system development (GO:0072001)2.70439088
86oxidative phosphorylation (GO:0006119)2.65693702
87regulation of tolerance induction (GO:0002643)2.64334737
88monocyte differentiation (GO:0030224)2.62159516
89nuclear pore organization (GO:0006999)2.60429829
90negative regulation of mRNA processing (GO:0050686)2.60022640
91rRNA processing (GO:0006364)2.59938720
92regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.57919148
93fusion of sperm to egg plasma membrane (GO:0007342)2.57018739
94heterochromatin organization (GO:0070828)2.56380752
95lung morphogenesis (GO:0060425)2.54293803
96peptidyl-arginine omega-N-methylation (GO:0035247)2.53411809
97maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.52873388
98low-density lipoprotein particle clearance (GO:0034383)2.52645734
99melanin biosynthetic process (GO:0042438)12.1066708
100melanin metabolic process (GO:0006582)11.1535959

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.79455058
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.29115178
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.20669719
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.62972051
5MYC_18358816_ChIP-ChIP_MESCs_Mouse2.91284912
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88971126
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.82423529
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.74652043
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.71643457
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63895032
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.63290390
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.52823759
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.50871499
14THAP11_20581084_ChIP-Seq_MESCs_Mouse2.49556298
15XRN2_22483619_ChIP-Seq_HELA_Human2.49246320
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44504930
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31632547
18DCP1A_22483619_ChIP-Seq_HELA_Human2.30021364
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23025624
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.19079088
21GABP_19822575_ChIP-Seq_HepG2_Human2.08210468
22ZFX_18555785_ChIP-Seq_MESCs_Mouse2.06358569
23TTF2_22483619_ChIP-Seq_HELA_Human2.04916444
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04901439
25AR_21909140_ChIP-Seq_LNCAP_Human2.03630411
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94571199
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88804931
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.87355820
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.83081811
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80697611
31MYC_22102868_ChIP-Seq_BL_Human1.76612696
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.74382966
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.72728896
34CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.69471681
35KDM5A_27292631_Chip-Seq_BREAST_Human1.69340566
36TFEB_21752829_ChIP-Seq_HELA_Human1.67040780
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66817924
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66074908
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.65526722
40CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.63147733
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.61088108
42KLF4_18555785_ChIP-Seq_MESCs_Mouse1.59317467
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58485086
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.56145799
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54979856
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51926162
47ZNF263_19887448_ChIP-Seq_K562_Human1.51459575
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44563530
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43962280
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42606400
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41019513
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35156724
53CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.34480242
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.32133127
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32003084
56HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31912155
57FOXP3_21729870_ChIP-Seq_TREG_Human1.31539872
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.31413600
59SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.31363167
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30474983
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.29378308
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28813101
63SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.26369319
64CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25692082
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23376126
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21121318
67VDR_21846776_ChIP-Seq_THP-1_Human1.20260685
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19864589
69TBX5_21415370_ChIP-Seq_HL-1_Mouse1.19084954
70CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.18764095
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18617482
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17391777
73VDR_23849224_ChIP-Seq_CD4+_Human1.16862504
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16088797
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14397552
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14344890
77LXR_22292898_ChIP-Seq_THP-1_Human1.14226852
78CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13419181
79CIITA_25753668_ChIP-Seq_RAJI_Human1.11180571
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11109081
81RACK7_27058665_Chip-Seq_MCF-7_Human1.11041570
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.08817407
83CLOCK_20551151_ChIP-Seq_293T_Human1.07208794
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06180212
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05415184
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03625428
87ELK1_19687146_ChIP-ChIP_HELA_Human1.02497981
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01965814
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01354357
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00772818
91KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00404018
92KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00404018
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00404018
94HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99954366
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99807703
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99242472
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.96352630
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.95187988
99PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94981155
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93245422

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005257_abnormal_intraocular_pressure6.33445248
2MP0003136_yellow_coat_color6.17997711
3MP0000372_irregular_coat_pigmentation4.28435214
4MP0005408_hypopigmentation3.92114925
5MP0002877_abnormal_melanocyte_morpholog3.57902163
6MP0005174_abnormal_tail_pigmentation3.46409163
7MP0000371_diluted_coat_color3.38318733
8MP0004381_abnormal_hair_follicle3.02672830
9MP0005075_abnormal_melanosome_morpholog2.89775307
10MP0002095_abnormal_skin_pigmentation2.72763381
11MP0002075_abnormal_coat/hair_pigmentati2.63478655
12MP0000015_abnormal_ear_pigmentation2.38170592
13MP0001186_pigmentation_phenotype2.24240078
14MP0003111_abnormal_nucleus_morphology2.03314291
15MP0005171_absent_coat_pigmentation10.0166670
16MP0001324_abnormal_eye_pigmentation1.94418993
17MP0010234_abnormal_vibrissa_follicle1.88049217
18MP0004957_abnormal_blastocyst_morpholog1.80311096
19MP0010094_abnormal_chromosome_stability1.76380104
20MP0008007_abnormal_cellular_replicative1.73597100
21MP0005197_abnormal_uvea_morphology1.71097534
22MP0003693_abnormal_embryo_hatching1.69227411
23MP0003077_abnormal_cell_cycle1.61191562
24MP0008932_abnormal_embryonic_tissue1.59833165
25MP0002938_white_spotting1.59573593
26MP0009697_abnormal_copulation1.58619004
27MP0000516_abnormal_urinary_system1.52832402
28MP0005367_renal/urinary_system_phenotyp1.52832402
29MP0005058_abnormal_lysosome_morphology1.40413455
30MP0001293_anophthalmia1.36159904
31MP0010030_abnormal_orbit_morphology1.22203160
32MP0003221_abnormal_cardiomyocyte_apopto1.13402337
33MP0006292_abnormal_olfactory_placode1.10174814
34MP0008438_abnormal_cutaneous_collagen1.05566577
35MP0009333_abnormal_splenocyte_physiolog1.05347163
36MP0002396_abnormal_hematopoietic_system1.03236052
37MP0001730_embryonic_growth_arrest0.93015223
38MP0008058_abnormal_DNA_repair0.92008875
39MP0000350_abnormal_cell_proliferation0.91724173
40MP0004742_abnormal_vestibular_system0.87903543
41MP0003718_maternal_effect0.86554142
42MP0005076_abnormal_cell_differentiation0.83545381
43MP0000762_abnormal_tongue_morphology0.82232968
44MP0003943_abnormal_hepatobiliary_system0.81746476
45MP0005451_abnormal_body_composition0.80913473
46MP0003385_abnormal_body_wall0.80265865
47MP0009379_abnormal_foot_pigmentation0.80207431
48MP0002092_abnormal_eye_morphology0.79318791
49MP0003186_abnormal_redox_activity0.76987144
50MP0004185_abnormal_adipocyte_glucose0.75021561
51MP0000534_abnormal_ureter_morphology0.74235239
52MP0004233_abnormal_muscle_weight0.74033114
53MP0002080_prenatal_lethality0.72945012
54MP0003786_premature_aging0.72468342
55MP0002177_abnormal_outer_ear0.71022257
56MP0002084_abnormal_developmental_patter0.70343578
57MP0000751_myopathy0.69933243
58MP0002090_abnormal_vision0.68111110
59MP0005330_cardiomyopathy0.68050989
60MP0005193_abnormal_anterior_eye0.65832710
61MP0005377_hearing/vestibular/ear_phenot0.64505893
62MP0003878_abnormal_ear_physiology0.64505893
63MP0000747_muscle_weakness0.64322129
64MP0005380_embryogenesis_phenotype0.63709526
65MP0001672_abnormal_embryogenesis/_devel0.63709526
66MP0008775_abnormal_heart_ventricle0.62382587
67MP0002085_abnormal_embryonic_tissue0.60229562
68MP0001661_extended_life_span0.59344329
69MP0003172_abnormal_lysosome_physiology0.59252742
70MP0002060_abnormal_skin_morphology0.58769758
71MP0003119_abnormal_digestive_system0.58728437
72MP0002697_abnormal_eye_size0.53903570
73MP0000367_abnormal_coat/_hair0.53087624
74MP0003453_abnormal_keratinocyte_physiol0.51911353
75MP0008961_abnormal_basal_metabolism0.51309867
76MP0001697_abnormal_embryo_size0.49314402
77MP0002751_abnormal_autonomic_nervous0.47314842
78MP0002210_abnormal_sex_determination0.47079107
79MP0003984_embryonic_growth_retardation0.46096349
80MP0002086_abnormal_extraembryonic_tissu0.45226321
81MP0001348_abnormal_lacrimal_gland0.44838482
82MP0003935_abnormal_craniofacial_develop0.43842541
83MP0005391_vision/eye_phenotype0.43707768
84MP0000377_abnormal_hair_follicle0.43640749
85MP0000678_abnormal_parathyroid_gland0.42703898
86MP0000313_abnormal_cell_death0.42137299
87MP0000358_abnormal_cell_content/0.41340955
88MP0006036_abnormal_mitochondrial_physio0.41313931
89MP0002088_abnormal_embryonic_growth/wei0.41163434
90MP0003938_abnormal_ear_development0.38826613
91MP0000749_muscle_degeneration0.38436916
92MP0000569_abnormal_digit_pigmentation0.37954170
93MP0000432_abnormal_head_morphology0.36955135
94MP0006035_abnormal_mitochondrial_morpho0.35904446
95MP0002102_abnormal_ear_morphology0.35391123
96MP0004197_abnormal_fetal_growth/weight/0.33335032
97MP0000681_abnormal_thyroid_gland0.32121783
98MP0000026_abnormal_inner_ear0.31934258
99MP0002269_muscular_atrophy0.31578411
100MP0001145_abnormal_male_reproductive0.30309399

Predicted human phenotypes

RankGene SetZ-score
1White forelock (HP:0002211)9.11797599
2Patchy hypopigmentation of hair (HP:0011365)8.68745760
3Heterochromia iridis (HP:0001100)5.70436816
4Delayed CNS myelination (HP:0002188)5.19173541
5Premature graying of hair (HP:0002216)5.18516395
6Blue irides (HP:0000635)5.15034811
7Ocular albinism (HP:0001107)5.05594933
8Microglossia (HP:0000171)4.97969288
9Spastic paraparesis (HP:0002313)4.80001202
10Hypopigmentation of the fundus (HP:0007894)4.66347301
11Albinism (HP:0001022)4.57404455
12Generalized hypopigmentation (HP:0007513)4.21143561
13Iris hypopigmentation (HP:0007730)4.21041587
14Adrenal hypoplasia (HP:0000835)4.16783125
15Proximal placement of thumb (HP:0009623)3.95637134
16Abnormal auditory evoked potentials (HP:0006958)3.85669401
17Aplasia/Hypoplasia of the macula (HP:0008059)3.75849624
18Aplasia/Hypoplasia affecting the retina (HP:0008061)3.62946782
19Deviation of the thumb (HP:0009603)3.58271186
20Premature rupture of membranes (HP:0001788)3.53285063
21Abnormal autonomic nervous system physiology (HP:0012332)3.52791672
22Large for gestational age (HP:0001520)3.20441502
23Paraparesis (HP:0002385)3.02475917
24Aplasia/Hypoplasia of the fovea (HP:0008060)2.89560361
25Hypoplasia of the fovea (HP:0007750)2.89560361
26Underdeveloped nasal alae (HP:0000430)2.88308417
27Cutaneous melanoma (HP:0012056)2.67253301
28Abnormality of the sella turcica (HP:0002679)2.66861940
29Cerebral hypomyelination (HP:0006808)2.61433087
30Osteolytic defects of the phalanges of the hand (HP:0009771)2.57470545
31Osteolytic defects of the hand bones (HP:0009699)2.57470545
32Congenital sensorineural hearing impairment (HP:0008527)2.47771433
33Multiple enchondromatosis (HP:0005701)2.43067845
34Achilles tendon contracture (HP:0001771)2.41973428
35Multiple lipomas (HP:0001012)2.39155912
36Hypokinesia (HP:0002375)2.36193173
37Progressive muscle weakness (HP:0003323)2.35443530
38Insidious onset (HP:0003587)2.31795793
39Termporal pattern (HP:0011008)2.31795793
40Glossoptosis (HP:0000162)2.30816334
41Severe muscular hypotonia (HP:0006829)2.29455732
42Trismus (HP:0000211)2.24686228
43Orthostatic hypotension (HP:0001278)2.23269186
44Increased connective tissue (HP:0009025)2.19764288
45Degeneration of anterior horn cells (HP:0002398)2.17177288
46Abnormality of the anterior horn cell (HP:0006802)2.17177288
47Abnormality of the fovea (HP:0000493)2.16302355
48Neoplasm of head and neck (HP:0012288)2.15262517
49Esophageal neoplasm (HP:0100751)2.15262517
50Abnormality of the umbilical cord (HP:0010881)2.06752827
51Abnormality of the Achilles tendon (HP:0005109)2.03549468
52Distal lower limb muscle weakness (HP:0009053)2.00847470
53Short nail (HP:0001799)1.99576594
54Growth hormone excess (HP:0000845)1.98572417
55Aplasia cutis congenita (HP:0001057)1.96169550
56Elbow flexion contracture (HP:0002987)1.94231043
57Ragged-red muscle fibers (HP:0003200)1.92760533
58Conjunctival hamartoma (HP:0100780)1.92105291
59Dysphonia (HP:0001618)1.91602000
60Atresia of the external auditory canal (HP:0000413)1.91184932
61Freckling (HP:0001480)1.89647092
62Diaphragmatic weakness (HP:0009113)1.89432277
63Anophthalmia (HP:0000528)1.87833242
64Progressive external ophthalmoplegia (HP:0000590)1.87042583
65Reticulocytopenia (HP:0001896)1.86554326
66Overlapping toe (HP:0001845)1.86186386
67Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.86017145
68Absent epiphyses (HP:0010577)1.86017145
69Protruding ear (HP:0000411)1.85873550
70Ulnar bowing (HP:0003031)1.82808965
71Chromosomal breakage induced by crosslinking agents (HP:0003221)1.82456431
72Abnormality of the distal phalanges of the toes (HP:0010182)1.82365637
73Bilateral sensorineural hearing impairment (HP:0008619)1.82177774
74Alacrima (HP:0000522)1.81952810
75Impaired proprioception (HP:0010831)1.81631839
76Intestinal polyposis (HP:0200008)1.78034204
77Intestinal polyp (HP:0005266)1.76535490
78Plagiocephaly (HP:0001357)1.74324039
79Sparse eyelashes (HP:0000653)1.72343331
80Entropion (HP:0000621)1.68980691
81Tongue fasciculations (HP:0001308)1.66730892
82Rough bone trabeculation (HP:0100670)1.66555197
83Birth length less than 3rd percentile (HP:0003561)1.66143233
84Hypopigmented skin patches (HP:0001053)1.66051185
85Peripheral hypomyelination (HP:0007182)1.64495575
86Distal lower limb amyotrophy (HP:0008944)1.64279917
87Abnormality of subcutaneous fat tissue (HP:0001001)1.63492355
88Synophrys (HP:0000664)1.63337958
89Redundant skin (HP:0001582)1.61661605
90Late onset (HP:0003584)1.60392591
91Hypoplasia of the iris (HP:0007676)1.59560096
92Progressive hearing impairment (HP:0001730)1.57011009
93Microvesicular hepatic steatosis (HP:0001414)1.56734166
94Abnormality of the fetal cardiovascular system (HP:0010948)1.55579136
95Abnormal umbilical cord blood vessels (HP:0011403)1.55579136
96Single umbilical artery (HP:0001195)1.55579136
97Bifid scrotum (HP:0000048)1.54964841
98Selective tooth agenesis (HP:0001592)1.53282308
99Chromsome breakage (HP:0040012)1.52206821
100Abnormalities of placenta or umbilical cord (HP:0001194)1.52183983

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.53391485
2NME24.13200102
3CDK123.09616988
4PBK3.02969595
5TSSK62.86499985
6EIF2AK12.83352381
7ICK2.81633668
8DDR22.71636045
9MAP3K62.67611139
10TRIB32.34471533
11MST42.32179979
12WEE12.17556570
13TNIK2.10083757
14NEK22.08467581
15SCYL22.07853818
16MST1R2.00678682
17CDK31.92341727
18EEF2K1.91569708
19NME11.91141654
20EIF2AK31.67398007
21SMG11.56485774
22CDC71.55957029
23PDK21.54203635
24PASK1.51044867
25SRPK11.43751885
26NEK11.42720847
27PRKD31.39353199
28TTK1.35577459
29MAP3K81.24710137
30PAK41.24296559
31MET1.21880381
32AKT21.16047569
33IRAK31.12874875
34ERBB41.10088678
35BRD41.09985586
36TESK21.08155918
37PRKG21.07996784
38ALK1.06002629
39KSR21.05018918
40CDK71.01741493
41CHEK21.00261886
42STK161.00014545
43CHEK10.95656496
44MARK30.95118882
45MAP2K30.94493884
46SIK30.93833420
47CDK180.93295933
48PLK10.93059752
49CDK150.92680271
50CDK11A0.92347547
51MAPKAPK30.91468346
52EPHA20.90806575
53STK100.89961281
54RPS6KB20.89217523
55PKN20.88533111
56LRRK20.88454854
57MAP2K20.87077661
58CCNB10.86298701
59SIK10.80411944
60CDK140.77972252
61MKNK10.74777538
62MAP2K60.71829148
63MTOR0.71096024
64BRAF0.70670474
65MAP2K70.68272765
66ATR0.67834941
67TAOK20.65898182
68AURKB0.64497944
69BRSK10.59120143
70CSNK2A20.58549191
71ERN10.58298921
72CDK10.56671741
73DYRK30.56578629
74MAP2K40.55900916
75PRPF4B0.55207263
76CDK20.53326199
77TRIM280.52629754
78MAP3K100.46441410
79RET0.44300836
80TGFBR10.43638275
81PAK20.41699553
82MELK0.39913733
83CSNK2A10.39839991
84ATM0.39459449
85CSNK1A1L0.38649306
86MAP2K10.38246710
87ILK0.38162178
88CDK40.36658607
89CSNK1G30.35799104
90CSNK1E0.35777453
91MAP3K20.34342442
92CDK90.34092321
93PDGFRA0.33949878
94PDPK10.33940916
95NEK60.33884337
96STK40.33834669
97CLK10.33603225
98MAPK110.32226331
99GSK3A0.31792824
100PLK30.31639323

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.60920411
2Spliceosome_Homo sapiens_hsa030403.60555109
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.40040248
4Sulfur relay system_Homo sapiens_hsa041223.34743638
5Tyrosine metabolism_Homo sapiens_hsa003503.30358576
6DNA replication_Homo sapiens_hsa030303.23330445
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.11399382
8RNA polymerase_Homo sapiens_hsa030202.59527267
9Ribosome_Homo sapiens_hsa030102.59242448
10RNA transport_Homo sapiens_hsa030132.47186523
11Non-homologous end-joining_Homo sapiens_hsa034502.34312062
12Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.22935570
13Base excision repair_Homo sapiens_hsa034102.21224495
14Melanogenesis_Homo sapiens_hsa049162.06977761
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.06316322
16Cell cycle_Homo sapiens_hsa041101.96055467
17Pyrimidine metabolism_Homo sapiens_hsa002401.87089693
18Folate biosynthesis_Homo sapiens_hsa007901.84092605
19Nucleotide excision repair_Homo sapiens_hsa034201.79729045
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73865952
21Biosynthesis of amino acids_Homo sapiens_hsa012301.73809735
22mRNA surveillance pathway_Homo sapiens_hsa030151.67716407
23N-Glycan biosynthesis_Homo sapiens_hsa005101.62337849
24Pentose phosphate pathway_Homo sapiens_hsa000301.61427606
25One carbon pool by folate_Homo sapiens_hsa006701.52466138
26Mismatch repair_Homo sapiens_hsa034301.41727386
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.41515483
28Prion diseases_Homo sapiens_hsa050201.39733664
29Hedgehog signaling pathway_Homo sapiens_hsa043401.39526123
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.37501196
31Antigen processing and presentation_Homo sapiens_hsa046121.36008045
32Basal cell carcinoma_Homo sapiens_hsa052171.24128750
33Epstein-Barr virus infection_Homo sapiens_hsa051691.14739914
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.13342470
35Purine metabolism_Homo sapiens_hsa002301.07738807
36Basal transcription factors_Homo sapiens_hsa030221.06494340
37Arginine and proline metabolism_Homo sapiens_hsa003301.03595987
38Fructose and mannose metabolism_Homo sapiens_hsa000511.02339354
39Parkinsons disease_Homo sapiens_hsa050121.01207070
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97710737
41Oxidative phosphorylation_Homo sapiens_hsa001900.97313364
42Galactose metabolism_Homo sapiens_hsa000520.96975037
43Carbon metabolism_Homo sapiens_hsa012000.93028060
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.90525994
45RNA degradation_Homo sapiens_hsa030180.88265982
46Protein export_Homo sapiens_hsa030600.88237101
47Thyroid cancer_Homo sapiens_hsa052160.87355058
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85196441
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84019650
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82880884
51Huntingtons disease_Homo sapiens_hsa050160.79845401
52Herpes simplex infection_Homo sapiens_hsa051680.78048331
53Glutathione metabolism_Homo sapiens_hsa004800.76463922
54Alzheimers disease_Homo sapiens_hsa050100.75969155
55Oocyte meiosis_Homo sapiens_hsa041140.69436828
56Viral myocarditis_Homo sapiens_hsa054160.68137645
57TGF-beta signaling pathway_Homo sapiens_hsa043500.67894219
58Other glycan degradation_Homo sapiens_hsa005110.64271744
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64039871
60Vibrio cholerae infection_Homo sapiens_hsa051100.62586022
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60414993
62Pyruvate metabolism_Homo sapiens_hsa006200.57711388
63Homologous recombination_Homo sapiens_hsa034400.56364496
64Adherens junction_Homo sapiens_hsa045200.55911891
65Notch signaling pathway_Homo sapiens_hsa043300.54717226
66Viral carcinogenesis_Homo sapiens_hsa052030.54504805
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52604523
68Arginine biosynthesis_Homo sapiens_hsa002200.51573498
69HTLV-I infection_Homo sapiens_hsa051660.51167193
70Lysosome_Homo sapiens_hsa041420.50972486
71Apoptosis_Homo sapiens_hsa042100.49211546
72Pancreatic cancer_Homo sapiens_hsa052120.48015859
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47363431
74Chronic myeloid leukemia_Homo sapiens_hsa052200.47247775
75Type I diabetes mellitus_Homo sapiens_hsa049400.46405030
76Fanconi anemia pathway_Homo sapiens_hsa034600.44960657
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.42751121
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41545485
79VEGF signaling pathway_Homo sapiens_hsa043700.40273857
80Wnt signaling pathway_Homo sapiens_hsa043100.39152261
81Vitamin digestion and absorption_Homo sapiens_hsa049770.39129495
82Autoimmune thyroid disease_Homo sapiens_hsa053200.37842624
83Metabolic pathways_Homo sapiens_hsa011000.37628708
84Allograft rejection_Homo sapiens_hsa053300.37466697
85Small cell lung cancer_Homo sapiens_hsa052220.37232154
86Hippo signaling pathway_Homo sapiens_hsa043900.37203354
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.37141716
88Shigellosis_Homo sapiens_hsa051310.35783268
89Sphingolipid metabolism_Homo sapiens_hsa006000.34272008
90Bladder cancer_Homo sapiens_hsa052190.31607157
91MicroRNAs in cancer_Homo sapiens_hsa052060.29849810
92Pathways in cancer_Homo sapiens_hsa052000.27974153
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27365623
94Graft-versus-host disease_Homo sapiens_hsa053320.25982757
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25043745
96Mineral absorption_Homo sapiens_hsa049780.24224688
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24078131
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20380332
99Non-small cell lung cancer_Homo sapiens_hsa052230.18563024
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17800087

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